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Aliases for OVGP1 Gene

Aliases for OVGP1 Gene

  • Oviductal Glycoprotein 1, 120kDa 2 3
  • Oviductin 2 3 4
  • Estrogen-Dependent Oviduct Protein 3 4
  • Mucin 9 2 3
  • Mucin-9 3 4
  • MUC9 3 4
  • OGP 3 4
  • Oviduct-Specific Glycoprotein 3
  • Oviductal Glycoprotein 4
  • Oviduct Glycoprotein 3
  • CHIT5 3
  • EGP 3

External Ids for OVGP1 Gene

Previous Symbols for OVGP1 Gene

  • MUC9

Summaries for OVGP1 Gene

Entrez Gene Summary for OVGP1 Gene

  • This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]

GeneCards Summary for OVGP1 Gene

OVGP1 (Oviductal Glycoprotein 1, 120kDa) is a Protein Coding gene. Diseases associated with OVGP1 include osteoporosis. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include chitinase activity. An important paralog of this gene is CHI3L2.

UniProtKB/Swiss-Prot for OVGP1 Gene

  • Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development

Gene Wiki entry for OVGP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVGP1 Gene

Genomics for OVGP1 Gene

Genomic Location for OVGP1 Gene

Start:
111,414,314 bp from pter
End:
111,427,777 bp from pter
Size:
13,464 bases
Orientation:
Minus strand

Genomic View for OVGP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVGP1 Gene

Regulatory Elements for OVGP1 Gene

Proteins for OVGP1 Gene

  • Protein details for OVGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12889-OVGP1_HUMAN
    Recommended name:
    Oviduct-specific glycoprotein
    Protein Accession:
    Q12889
    Secondary Accessions:
    • A0AV19
    • B9EGE1
    • Q15841

    Protein attributes for OVGP1 Gene

    Size:
    678 amino acids
    Molecular mass:
    75421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVGP1 Gene

Proteomics data for OVGP1 Gene at MOPED

Post-translational modifications for OVGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn402, Asn441, Asn580, Asn596, and Asn648

Other Protein References for OVGP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OVGP1 Gene

Domains for OVGP1 Gene

Gene Families for OVGP1 Gene

HGNC:

UniProtKB/Swiss-Prot:

OVGP1_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 18 family.:
    • Q12889
genes like me logo Genes that share domains with OVGP1: view

Function for OVGP1 Gene

Molecular function for OVGP1 Gene

UniProtKB/Swiss-Prot Function: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development

Gene Ontology (GO) - Molecular Function for OVGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004568 chitinase activity IBA --
GO:0008061 chitin binding IBA --
genes like me logo Genes that share ontologies with OVGP1: view

Phenotypes for OVGP1 Gene

MGI mutant phenotypes for OVGP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for OVGP1:
genes like me logo Genes that share phenotypes with OVGP1: view

Animal Models for OVGP1 Gene

MGI Knock Outs for OVGP1:

miRNA for OVGP1 Gene

miRTarBase miRNAs that target OVGP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OVGP1 Gene

Localization for OVGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVGP1 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVGP1 Gene COMPARTMENTS Subcellular localization image for OVGP1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OVGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0005829 cytosol TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle --
GO:0035805 egg coat IEA --
genes like me logo Genes that share ontologies with OVGP1: view

Pathways for OVGP1 Gene

SuperPathways for OVGP1 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with OVGP1: view

Pathways by source for OVGP1 Gene

Gene Ontology (GO) - Biological Process for OVGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006032 chitin catabolic process IBA --
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0007565 female pregnancy TAS 9341614
genes like me logo Genes that share ontologies with OVGP1: view

Compounds for OVGP1 Gene

(3) Novoseek inferred chemical compound relationships for OVGP1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 35.6 4
progesterone 29.4 3
gold 3.91 1
genes like me logo Genes that share compounds with OVGP1: view

Transcripts for OVGP1 Gene

Unigene Clusters for OVGP1 Gene

Oviductal glycoprotein 1, 120kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OVGP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - -
SP2: -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for OVGP1 Gene

GeneLoc Exon Structure for
OVGP1
ECgene alternative splicing isoforms for
OVGP1

Expression for OVGP1 Gene

mRNA expression in normal human tissues for OVGP1 Gene

mRNA differential expression in normal tissues according to GTEx for OVGP1 Gene

This gene is overexpressed in Fallopian Tube (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OVGP1 Gene

SOURCE GeneReport for Unigene cluster for OVGP1 Gene Hs.1154

mRNA Expression by UniProt/SwissProt for OVGP1 Gene

Q12889-OVGP1_HUMAN
Tissue specificity: Oviduct
genes like me logo Genes that share expressions with OVGP1: view

Orthologs for OVGP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVGP1 36
  • 99.25 (n)
  • 98.64 (a)
OVGP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 80 (a)
OneToMany
LOC100138271 36
  • 79.6 (n)
  • 71.73 (a)
OVGP1 37
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OVGP1 36
  • 79.37 (n)
  • 70.44 (a)
OVGP1 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovgp1 36
  • 74 (n)
  • 67.62 (a)
Ovgp1 16
Ovgp1 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVGP1 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVGP1 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OVGP1 37
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chia.3 37
  • 42 (a)
OneToMany
chia.4 37
  • 40 (a)
OneToMany
chia.6 37
  • 40 (a)
OneToMany
OVGP1 (3 of 4) 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cht7 37
  • 19 (a)
OneToMany
Cht3 38
  • 35 (a)
CG10531 38
  • 35 (a)
CG9357 38
  • 38 (a)
CG3044 38
  • 30 (a)
Cht2 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea cht-1 37
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTS2 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8046 37
  • 23 (a)
OneToMany
Species with no ortholog for OVGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OVGP1 Gene

ENSEMBL:
Gene Tree for OVGP1 (if available)
TreeFam:
Gene Tree for OVGP1 (if available)

Paralogs for OVGP1 Gene

Paralogs for OVGP1 Gene

Selected SIMAP similar genes for OVGP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OVGP1: view

Variants for OVGP1 Gene

Sequence variations from dbSNP and Humsavar for OVGP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7825 - 111,414,475(+) TTCTT(C/G)ATCCA missense, reference
rs9629 -- 111,414,623(+) ATGAC(A/G)GGGCT reference, synonymous-codon
rs10067 - 111,414,689(+) CTGGG(C/G)TGAGT reference, missense
rs954739 -- 111,423,669(+) ATAAA(C/T)TTTTC synonymous-codon, reference
rs1126656 - 111,414,961(-) TGGGT(C/T)ATCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OVGP1 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
nsv824131 CNV Loss 20364138
esv2716218 CNV Deletion 23290073
esv2100138 CNV Deletion 18987734

Relevant External Links for OVGP1 Gene

HapMap Linkage Disequilibrium report
OVGP1
Human Gene Mutation Database (HGMD)
OVGP1

Disorders for OVGP1 Gene

(1) MalaCards Diseases for OVGP1 Gene

Search for OVGP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for OVGP1 Gene

(2) Novoseek inferred disease relationships for OVGP1 Gene

Disease -log(P) Hits PubMed IDs
osteoporosis 20.5 2
bone loss 12.2 2

Relevant External Links for OVGP1

Genetic Association Database (GAD)
OVGP1
Human Genome Epidemiology (HuGE) Navigator
OVGP1
genes like me logo Genes that share disorders with OVGP1: view

No data available for UniProtKB/Swiss-Prot for OVGP1 Gene

Publications for OVGP1 Gene

  1. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. (PMID: 7819450) Arias E.B. … Jaffe R.C. (Biol. Reprod. 1994) 2 3 4 23
  2. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). (PMID: 9341614) LapensAce L. … Bleau G. (Fertil. Steril. 1997) 2 3 23
  3. Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. (PMID: 11818519) Agarwal A. … Lee K.F. (Mol. Hum. Reprod. 2002) 3 23
  4. Expression of human oviductin in an immortalized human oviductal cell line. (PMID: 16209999) Ling L. … Kan F.W. (Fertil. Steril. 2005) 3 23
  5. Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. (PMID: 16567366) Kadam K.M. … Natraj U. (Mol. Hum. Reprod. 2006) 3 23

Products for OVGP1 Gene

Sources for OVGP1 Gene

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