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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OVGP1 Gene

protein-coding   GIFtS: 60
GCID: GC01M111956

Oviductal Glycoprotein 1, 120kDa

(Previous name: mucin 9)
(Previous symbol: MUC9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oviductal Glycoprotein 1, 120kDa1 2     EGP2
MUC91 2 3     mucin-92
Mucin 91 2     Oviduct Glycoprotein2
oviductin1 2     Oviduct-Specific Glycoprotein2
Estrogen-Dependent Oviduct Protein2 3     Mucin-93
OGP2 3     Oviductin3
CHIT52     Oviductal Glycoprotein3

External Ids:    HGNC: 85241   Entrez Gene: 50162   Ensembl: ENSG000000854657   OMIM: 6035785   UniProtKB: Q128893   

Export aliases for OVGP1 gene to outside databases

Previous GC identifers: GC01M112373 GC01M110828 GC01M111002 GC01M111255 GC01M111668 GC01M111758 GC01M109828


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OVGP1 Gene:
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located
within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the
glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and
protein secretion occur during late follicular development through early cleavage-stage embryonic development.
The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes,
blastomeres, and spermatozoan acrosomal regions. (provided by RefSeq, Jul 2008)

GeneCards Summary for OVGP1 Gene: 
OVGP1 (oviductal glycoprotein 1, 120kDa) is a protein-coding gene. Diseases associated with OVGP1 include taylor's syndrome, and chitotriosidase deficiency, and among its related super-pathways are Interaction With The Zona Pellucida. GO annotations related to this gene include cation binding and chitinase activity. An important paralog of this gene is CHI3L1.

UniProtKB/Swiss-Prot: OVGP1_HUMAN, Q12889
Function: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early
embryonic development

Gene Wiki entry for OVGP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OVGP1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx2-5   Nkx3-1 v1   AREB6   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOVGP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OVGP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVGP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

OVGP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVGP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111956:  view genomic region     (about GC identifiers)

Start:
111,956,936 bp from pter      End:
111,970,399 bp from pter
Size:
13,464 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OVGP1_HUMAN, Q12889 (See protein sequence)
Recommended Name: Oviduct-specific glycoprotein precursor  
Size: 678 amino acids; 75421 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules
Secondary accessions: A0AV19 B9EGE1 Q15841

Explore the universe of human proteins at neXtProt for OVGP1: NX_Q12889

Explore proteomics data for OVGP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12889

  • OVGP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OVGP1 Protein Expression
    REFSEQ proteins: NP_002548.3  
    ENSEMBL proteins: 
     ENSP00000358747   ENSP00000438449  
    Reactome Protein details: Q12889
    Human Recombinant Protein Products for OVGP1: 
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    OriGene Protein Over-expression Lysate for OVGP1
    OriGene MassSpec for OVGP1 
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    GenScript Custom Purified and Recombinant Proteins Services for OVGP1
    Novus Biologicals OVGP1 Proteins
    Novus Biologicals OVGP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OVGP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030133transport vesicle IEA--

    OVGP1 for ontologies           About GeneDecksing



    OVGP1 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for OVGP1 
    ThermoFisher Antibodies for OVGP1
    LSBio Antibodies in human, mouse, rat for OVGP1 

    Assay Products for OVGP1: 
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    Cloud-Clone Corp. ELISAs for OVGP1 
    Cloud-Clone Corp. CLIAs for OVGP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    4 InterPro protein domains:
     IPR011583 Chitinase_II
     IPR017853 Glycoside_hydrolase_SF
     IPR001223 Glyco_hydro18cat
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry Q12889

    ProtoNet protein and cluster: Q12889

    3 Blocks protein domains:
    IPB001223 Glycoside hydrolase
    IPB001579 Glycoside hydrolase
    IPB011583 Chitinase II


    UniProtKB/Swiss-Prot: OVGP1_HUMAN, Q12889
    Similarity: Belongs to the glycosyl hydrolase 18 family


    OVGP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OVGP1_HUMAN, Q12889
    Function: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early
    embryonic development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004568chitinase activity IEA--
         
    OVGP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for OVGP1:
     Increased S DNA content  Increased cell number in G1, s 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ovgp1):
     reproductive system 

    OVGP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ovgp1tm1Yar for OVGP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OVGP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OVGP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OVGP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OVGP1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OVGP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate OVGP1:
    hsa-miR-581
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    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for OVGP1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of OVGP1

    Clone
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    GenScript: all cDNA clones in your preferred vector: OVGP1 (NM_002557)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OVGP1
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                         Customized lentivirus expression plasmids for stable overexpression of OVGP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVGP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OVGP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fertilization
    Fertilization0.38
    Interaction With The Zona Pellucida0.38
    Reproduction0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for OVGP1
        Fertilization
    Reproduction
    Interaction With The Zona Pellucida



    OVGP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OVGP1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for OVGP1 (Q128892, 3 ENSP000003587474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASA4O433742, 3, ENSP000002629404MINT-63137 I2D: score=3 STRING: ENSP00000262940
    STATHP028083, ENSP000002468954I2D: score=1 STRING: ENSP00000246895
    MYH9P355793, ENSP000002161814I2D: score=1 STRING: ENSP00000216181
    ASLENSP000003071884STRING: ENSP00000307188
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006032chitin catabolic process IEA--
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--
    GO:0007565female pregnancy TAS9341614

    OVGP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OVGP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OVGP1

    3 Novoseek inferred chemical compound relationships for OVGP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 35.6 5 16567366 (1), 20130498 (1), 15587109 (1), 11468776 (1)
    progesterone 29.4 3 9433970 (2), 8527847 (1)
    gold 3.91 1 9282986 (1)

    Search CenterWatch for drugs/clinical trials and news about OVGP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OVGP1 gene: 
    NM_002557.3  

    Unigene Cluster for OVGP1:

    Oviductal glycoprotein 1, 120kDa
    Hs.1154  [show with all ESTs]
    Unigene Representative Sequence: AB208783
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369732(uc001eaz.3 uc010owb.2 uc001eba.3 uc010owc.1)
    ENST00000494622 ENST00000481495 ENST00000540696
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OVGP1:
    hsa-miR-581
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OVGP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OVGP1
    Clone
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    OriGene clones in human, mouse for OVGP1 (see all 7)
    OriGene ORF clones in mouse, rat for OVGP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OVGP1 (NM_002557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OVGP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVGP1
    Sirion Biotech Customized lentivirus for stable overexpression of OVGP1 
                         Customized lentivirus expression plasmids for stable overexpression of OVGP1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OVGP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OVGP1

    Additional mRNA sequence: 

    AB208783.1 AK295207.1 AK298757.1 AK301726.1 AK314074.1 AY189737.1 BC126177.1 BC136406.1 
    U09550.1 

    10 DOTS entries:

    DT.113133  DT.91888618  DT.97827572  DT.121362477  DT.121362458  DT.121362449  DT.95363680  DT.121362608 
    DT.86846953  DT.87002902 

    24/549 AceView cDNA sequences (see all 549):

    AA977178 CA430509 AI634063 W92370 AA652299 BU166776 AA579661 BC001679 
    AA810573 CB125179 BQ439894 CA975957 BI868734 AI052688 AB073603 CR607217 
    N35294 BQ058018 BE904767 U09550 W92371 BF309688 AI754998 BG774401 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for OVGP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                          -           -                       -                                                         
    SP2:                                                              -                                                         
    SP3:              -     -     -           -                       -                                                         
    SP4:              -     -     -           -                                                                                 
    SP5:                                      -                                                                                 


    ECgene alternative splicing isoforms for OVGP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OVGP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAAGCCT
    OVGP1 Expression
    About this image


    See OVGP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OVGP1

    SOURCE GeneReport for Unigene cluster: Hs.1154

    UniProtKB/Swiss-Prot: OVGP1_HUMAN, Q12889
    Tissue specificity: Oviduct

        SABiosciences Custom PCR Arrays for OVGP1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OVGP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVGP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OVGP1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ovgp11 , 5 oviductal glycoprotein 11, 5 72.78(n)1
    65.82(a)1
      3 (46.46 cM)5
    126591  NM_007696.21  NP_031722.11 
     1059737115 
    lizard
    (Anolis carolinensis)
    Reptilia OVGP16
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    49(a)
    47(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    4(119087442-119104236)
    4(119108959-119116195)
    zebrafish
    (Danio rerio)
    Actinopterygii OVGP1 (4 of 4)6
    chia.36
    (see all 4)
    chitinase, acidic.3
    (see all 4)
    45(a)
    38(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    11(25025737-25029795)
    11(25040784-25043717)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93573 chitinase 38(a)
    (best of 5)
      57B16   --
    worm
    (Caenorhabditis elegans)
    Secernentea C25A8.46
    T01C4.16
    (see all 33)
    Protein T01C4.1
    (see all 33)
    8(a)
    6(a)
    (see all 33)
    possible ortholog
    possible ortholog
    (see all 33)
    IV(7003625-7009269)
    V(7123658-7128890)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTS26
    Putative chitinase, functionally complements A. go...
    17(a)
    1 → many
    IV(1219413-1220948)


    ENSEMBL Gene Tree for OVGP1 (if available)
    TreeFam Gene Tree for OVGP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OVGP1 gene
    CHI3L12  CHIA2  CHIT12  CHI3L22  
    4 SIMAP similar genes for OVGP1 using alignment to 2 protein entries:     OVGP1_HUMAN (see all proteins):
    CHIA    CHI3L1    CHI3L2    CHIT1

    OVGP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/460 SNPs in OVGP1 are shown (see all 460)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357524
    A colorectal cancer sample4--see VAR_0357522 L H mis40--------
    rs1159588721,2
    F--111956459(+) CCTAGG/TAAAAT 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs17778331,2
    C,F,O,A,H--111956473(+) CCCTGA/GGTGGA 1 -- ds500121Minor allele frequency- G:0.20NS EA NA WA 2554
    rs1919422241,2
    --111956484(+) TTAAAA/GTTTTA 1 -- ds50010--------
    rs1857746711,2
    --111956581(+) TATACC/TTTTTC 1 -- ds50010--------
    rs782993691,2
    C,F--111956606(+) GAGGAG/AAGAAT 1 -- ds50012Minor allele frequency- A:0.12WA EA 238
    rs786353431,2
    --111956611(+) GAGAAC/TAGATG 1 -- ds50010--------
    rs66649981,2
    C,F,A,H--111956662(+) AGAATG/ATAATT 1 -- ds500130Minor allele frequency- A:0.38NA NS EA WA CSA 2911
    rs1902015011,2
    --111956683(+) ACTTCC/TCCCTC 1 -- ds50010--------
    rs1398198121,2
    --111956779(+) CAGCAA/GAGAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OVGP1 (111956936 - 111970399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OVGP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716218CNV Deletion23290073
    esv2100138CNV Deletion18987734
    nsv824131CNV Loss20364138
    nsv463250CNV Loss19166990


    Human Gene Mutation Database (HGMD): OVGP1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603578    OMIM disorders: --

    10 diseases for OVGP1:    About MalaCards
    taylor's syndrome    chitotriosidase deficiency    inclusion conjunctivitis    acrodermatitis
    conjunctivitis    hyperglycemia    laryngitis    ulcerative colitis
    ovarian cancer    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for OVGP1:
    Taylor's syndrome

    OVGP1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for OVGP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 20.5 2 16795077 (1), 7629225 (1)
    bone loss 12.2 2 16795077 (1), 7629225 (1)

    Genetic Association Database (GAD): OVGP1
    Human Genome Epidemiology (HuGE) Navigator: OVGP1 (1 document)

    Export disorders for OVGP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OVGP1 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with OVGP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. (PubMed id 7819450)1, 2, 3, 9 Arias E.B.... Jaffe R.C. (1994)
    2. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). (PubMed id 9341614)1, 3, 9 LapensAce L....Bleau G. (1997)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Oviductal glycoprotein (OVGP1, MUC9): a differentiati on-based mucin present in serum of women with ovarian cancer. (PubMed id 20130498)1, 9 Maines-Bandiera S....Auersperg N. (2010)
    7. Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. (PubMed id 11818519)1, 9 Agarwal A....Lee K.F. (2002)
    8. Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. (PubMed id 16567366)1, 9 Kadam K.M....Natraj U. (2006)
    9. Expression of human oviductin in an immortalized human oviductal cell line. (PubMed id 16209999)1, 9 Ling L....Kan F.W. (2005)
    10. Variable expression of oviductin mRNA at different stages of human reproductive cycle. (PubMed id 12503889)1, 9 Lok I.H....Haines C.J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5016 HGNC: 8524 AceView: OVGP1andMEP50 Ensembl:ENSG00000085465 euGenes: HUgn5016
    ECgene: OVGP1 H-InvDB: OVGP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OVGP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OVGP1 gene:
    Search GeneIP for patents involving OVGP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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