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Aliases for OVCH2 Gene

Aliases for OVCH2 Gene

  • Ovochymase 2 (Gene/Pseudogene) 2 3
  • OVTN 3 4
  • Oviductin Protease 3
  • Ovochymase 2 2
  • Ovochymase-2 3
  • EC 3.4.21.- 4
  • Oviductin 4

External Ids for OVCH2 Gene

Summaries for OVCH2 Gene

GeneCards Summary for OVCH2 Gene

OVCH2 (Ovochymase 2 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS56.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCH2 Gene

Genomics for OVCH2 Gene

Genomic Location for OVCH2 Gene

Start:
7,689,438 bp from pter
End:
7,706,454 bp from pter
Size:
17,017 bases
Orientation:
Minus strand

Genomic View for OVCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCH2 Gene

Regulatory Elements for OVCH2 Gene

Proteins for OVCH2 Gene

  • Protein details for OVCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTZ1-OVCH2_HUMAN
    Recommended name:
    Ovochymase-2
    Protein Accession:
    Q7RTZ1
    Secondary Accessions:

    Protein attributes for OVCH2 Gene

    Size:
    564 amino acids
    Molecular mass:
    62642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCH2 Gene

Proteomics data for OVCH2 Gene at MOPED

Post-translational modifications for OVCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn104, Asn415, Asn451, and Asn530

Other Protein References for OVCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCH2 Gene

Domains for OVCH2 Gene

UniProtKB/Swiss-Prot:

OVCH2_HUMAN
Domain:
  • Contains 2 CUB domains.:
    • Q7RTZ1
  • Contains 1 peptidase S1 domain.:
    • Q7RTZ1
Family:
  • Belongs to the peptidase S1 family.:
    • Q7RTZ1
genes like me logo Genes that share domains with OVCH2: view

No data available for Gene Families for OVCH2 Gene

Function for OVCH2 Gene

Enzyme Numbers (IUBMB) for OVCH2 Gene

Gene Ontology (GO) - Molecular Function for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVCH2: view

Phenotypes for OVCH2 Gene

GenomeRNAi human phenotypes for OVCH2:
genes like me logo Genes that share phenotypes with OVCH2: view

miRNA for OVCH2 Gene

miRTarBase miRNAs that target OVCH2

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for OVCH2 Gene

Localization for OVCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVCH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVCH2 Gene COMPARTMENTS Subcellular localization image for OVCH2 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OVCH2: view

Pathways for OVCH2 Gene

SuperPathways for OVCH2 Gene

No Data Available

Interacting Proteins for OVCH2 Gene

Gene Ontology (GO) - Biological Process for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Pathways by source for OVCH2 Gene

Transcripts for OVCH2 Gene

mRNA/cDNA for OVCH2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVCH2 Gene

Ovochymase 2 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OVCH2 Gene

No ASD Table

Relevant External Links for OVCH2 Gene

GeneLoc Exon Structure for
OVCH2
ECgene alternative splicing isoforms for
OVCH2

Expression for OVCH2 Gene

mRNA expression in normal human tissues for OVCH2 Gene

mRNA differential expression in normal tissues according to GTEx for OVCH2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.9), Skin - Sun Exposed (Lower leg) (8.7), Breast - Mammary Tissue (5.2), Bladder (4.6), and Prostate (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OVCH2 Gene

SOURCE GeneReport for Unigene cluster for OVCH2 Gene Hs.532475

genes like me logo Genes that share expressions with OVCH2: view

Orthologs for OVCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVCH2 36
  • 99 (n)
  • 97.7 (a)
OVCH2 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCH2 36
  • 84.16 (n)
  • 76.8 (a)
OVCH2 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OVCH2 36
  • 84.31 (n)
  • 78.79 (a)
OVCH2 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovch2 36
  • 82.5 (n)
  • 77.58 (a)
Ovch2 16
Ovch2 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCH2 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVCH2 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ovch2 36
  • 83.6 (n)
  • 78.25 (a)
chicken
(Gallus gallus)
Aves OVCH2 36
  • 65.13 (n)
  • 56.54 (a)
OVCH2 37
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OVCH2 37
  • 35 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398108 36
zebrafish
(Danio rerio)
Actinopterygii LOC101884131 36
  • 48.49 (n)
  • 40.65 (a)
ovch2 37
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11668 37
  • 16 (a)
ManyToMany
CG11670 37
  • 17 (a)
ManyToMany
CG11836 37
  • 32 (a)
ManyToMany
CG11841 37
  • 21 (a)
ManyToMany
CG11842 37
  • 19 (a)
ManyToMany
CG11843 37
  • 23 (a)
ManyToMany
CG1299 37
  • 18 (a)
ManyToMany
CG14642 37
  • 20 (a)
ManyToMany
CG14892 37
  • 18 (a)
ManyToMany
CG18735 37
  • 28 (a)
ManyToMany
CG31728 37
  • 13 (a)
ManyToMany
CG32260 37
  • 16 (a)
ManyToMany
CG3355 37
  • 28 (a)
ManyToMany
CG34350 37
  • 10 (a)
ManyToMany
CG3700 37
  • 21 (a)
ManyToMany
CG4386 37
  • 25 (a)
ManyToMany
CG4613 37
  • 23 (a)
ManyToMany
CG4914 37
  • 27 (a)
ManyToMany
CG4927 37
  • 22 (a)
ManyToMany
CG6361 37
  • 12 (a)
ManyToMany
CG6865 37
  • 28 (a)
ManyToMany
CG7432 37
  • 13 (a)
ManyToMany
CG8172 37
  • 18 (a)
ManyToMany
CG8213 37
  • 5 (a)
ManyToMany
CG9294 37
  • 23 (a)
ManyToMany
CG9372 37
  • 21 (a)
ManyToMany
psh 37
  • 18 (a)
ManyToMany
Sb 37
  • 13 (a)
ManyToMany
snk 37
  • 18 (a)
ManyToMany
spirit 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3856 37
  • 18 (a)
OneToOne
Species with no ortholog for OVCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OVCH2 Gene

ENSEMBL:
Gene Tree for OVCH2 (if available)
TreeFam:
Gene Tree for OVCH2 (if available)

Paralogs for OVCH2 Gene

Paralogs for OVCH2 Gene

genes like me logo Genes that share paralogs with OVCH2: view

Variants for OVCH2 Gene

Sequence variations from dbSNP and Humsavar for OVCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3924747 -- 7,703,545(+) TCACC(C/T)AGCCC intron-variant
rs3924748 -- 7,703,626(+) AATAG(A/G)GTTAT intron-variant
rs3925027 - 7,695,615(+) AAACC(C/G)AGCTG missense, reference
rs3925028 - 7,695,710(+) ATTTT(C/T)CTGCA missense, reference
rs4075013 -- 7,696,337(+) CAATT(C/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OVCH2 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2518653 CNV Deletion 19546169
nsv512206 CNV Loss 21212237
esv2164871 CNV Deletion 18987734
esv5220 CNV Deletion 18987735
esv2540661 CNV Deletion 19546169
dgv19n6 CNV Loss 16902084
esv990602 CNV Deletion 20482838
esv9107 CNV Loss 19470904
esv1223356 CNV Deletion 17803354
esv2744080 CNV Deletion 23290073

Relevant External Links for OVCH2 Gene

HapMap Linkage Disequilibrium report
OVCH2

Disorders for OVCH2 Gene

Relevant External Links for OVCH2

Genetic Association Database (GAD)
OVCH2
genes like me logo Genes that share disorders with OVCH2: view

No data available for UniProtKB/Swiss-Prot for OVCH2 Gene

Publications for OVCH2 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  3. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PMID: 19557197) Heard-Costa N.L. … North K.E. (PLoS Genet. 2009) 3 49

Products for OVCH2 Gene

Sources for OVCH2 Gene

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