Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OVCH2 Gene

Aliases for OVCH2 Gene

  • Ovochymase 2 (Gene/Pseudogene) 2 3 5
  • OVTN 3 4
  • Oviductin Protease 3
  • Ovochymase 2 2
  • Ovochymase-2 3
  • EC 3.4.21.- 4
  • Oviductin 4

External Ids for OVCH2 Gene

Previous GeneCards Identifiers for OVCH2 Gene

  • GC11M007371

Summaries for OVCH2 Gene

GeneCards Summary for OVCH2 Gene

OVCH2 (Ovochymase 2 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is OVCH1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCH2 Gene

Genomics for OVCH2 Gene

Regulatory Elements for OVCH2 Gene

Enhancers for OVCH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G007571 1.6 Ensembl ENCODE dbSUPER 9.8 +130.5 130520 9.3 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF766 ZNF143 OLFML1 OVCH2 PPFIBP2 NLRP10 LOC105376535 GC11M007541
GH11G007665 1.1 ENCODE dbSUPER 10.7 +40.4 40396 0.7 HDGF PKNOX1 RB1 ARID4B SIN3A ZNF2 RAD21 ZNF143 KLF7 CREM CYB5R2 LOC105376533 OVCH2 GC11P007617
GH11G007676 0.9 ENCODE dbSUPER 11.3 +29.1 29124 1.7 PKNOX1 FEZF1 ZNF398 ZIC2 ZNF843 ZNF518A ZFHX2 CTBP1 GLIS1 ZNF701 CYB5R2 EIF3F LOC100506258 LOC105376533 OVCH2 OLFML1 OR10AB1P ENSG00000275612
GH11G007904 0.9 Ensembl ENCODE 10.2 -200.1 -200131 4.4 CTCF ZNF680 CEBPB KLF4 RAD21 ATF2 POLR2A ATF3 GLIS1 SCRT2 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F LOC283299
GH11G007436 0.8 Ensembl ENCODE 10 +269.7 269668 0.8 GATA2 ZNF133 ZMYM3 FOS ETV6 SPI1 GABPA OLFML1 OVCH2 PIR51355 GC11M007412
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OVCH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OVCH2 Gene

Chromosome:
11
Start:
7,678,692 bp from pter
End:
7,706,454 bp from pter
Size:
27,763 bases
Orientation:
Minus strand

Genomic View for OVCH2 Gene

Genes around OVCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCH2 Gene

Proteins for OVCH2 Gene

  • Protein details for OVCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTZ1-OVCH2_HUMAN
    Recommended name:
    Ovochymase-2
    Protein Accession:
    Q7RTZ1

    Protein attributes for OVCH2 Gene

    Size:
    564 amino acids
    Molecular mass:
    62642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCH2 Gene

Post-translational modifications for OVCH2 Gene

  • Glycosylation at posLast=104104, Asn415, posLast=451451, and Asn530
  • Modification sites at PhosphoSitePlus

Other Protein References for OVCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCH2 Gene

Domains & Families for OVCH2 Gene

Suggested Antigen Peptide Sequences for OVCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTZ1

UniProtKB/Swiss-Prot:

OVCH2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with OVCH2: view

No data available for Gene Families for OVCH2 Gene

Function for OVCH2 Gene

Enzyme Numbers (IUBMB) for OVCH2 Gene

Gene Ontology (GO) - Molecular Function for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVCH2: view
genes like me logo Genes that share phenotypes with OVCH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OVCH2

CRISPR Products

miRNA for OVCH2 Gene

miRTarBase miRNAs that target OVCH2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCH2 Gene

Localization for OVCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVCH2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Subcellular locations from COMPARTMENTS for OVCH2 Gene

Pathways & Interactions for OVCH2 Gene

SuperPathways for OVCH2 Gene

No Data Available

Interacting Proteins for OVCH2 Gene

Gene Ontology (GO) - Biological Process for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Pathways by source and SIGNOR curated interactions for OVCH2 Gene

Drugs & Compounds for OVCH2 Gene

No Compound Related Data Available

Transcripts for OVCH2 Gene

mRNA/cDNA for OVCH2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVCH2 Gene

Ovochymase 2 (gene/pseudogene):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCH2 Gene

No ASD Table

Relevant External Links for OVCH2 Gene

GeneLoc Exon Structure for
OVCH2
ECgene alternative splicing isoforms for
OVCH2

Expression for OVCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVCH2 Gene

mRNA differential expression in normal tissues according to GTEx for OVCH2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.9), Skin - Sun Exposed (Lower leg) (x8.7), Breast - Mammary Tissue (x5.2), Bladder (x4.6), and Prostate (x4.1).

Protein differential expression in normal tissues from HIPED for OVCH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (62.8) and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVCH2 Gene



Protein tissue co-expression partners for OVCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCH2 Gene:

OVCH2

SOURCE GeneReport for Unigene cluster for OVCH2 Gene:

Hs.532475
genes like me logo Genes that share expression patterns with OVCH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVCH2 Gene

Orthologs for OVCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVCH2 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia OVCH2 34 35
  • 84.31 (n)
cow
(Bos Taurus)
Mammalia OVCH2 34 35
  • 84.16 (n)
rat
(Rattus norvegicus)
Mammalia Ovch2 34
  • 83.6 (n)
mouse
(Mus musculus)
Mammalia Ovch2 34 16 35
  • 82.5 (n)
oppossum
(Monodelphis domestica)
Mammalia OVCH2 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVCH2 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves OVCH2 34 35
  • 65.13 (n)
lizard
(Anolis carolinensis)
Reptilia OVCH2 35
  • 35 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398108 34
zebrafish
(Danio rerio)
Actinopterygii LOC101884131 34
  • 48.49 (n)
ovch2 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11836 35
  • 32 (a)
ManyToMany
CG18735 35
  • 28 (a)
ManyToMany
CG3355 35
  • 28 (a)
ManyToMany
CG6865 35
  • 28 (a)
ManyToMany
CG4914 35
  • 27 (a)
ManyToMany
CG4386 35
  • 25 (a)
ManyToMany
CG11843 35
  • 23 (a)
ManyToMany
CG4613 35
  • 23 (a)
ManyToMany
CG9294 35
  • 23 (a)
ManyToMany
CG4927 35
  • 22 (a)
ManyToMany
CG11841 35
  • 21 (a)
ManyToMany
CG3700 35
  • 21 (a)
ManyToMany
CG9372 35
  • 21 (a)
ManyToMany
spirit 35
  • 21 (a)
ManyToMany
CG14642 35
  • 20 (a)
ManyToMany
CG11842 35
  • 19 (a)
ManyToMany
CG1299 35
  • 18 (a)
ManyToMany
CG14892 35
  • 18 (a)
ManyToMany
CG8172 35
  • 18 (a)
ManyToMany
psh 35
  • 18 (a)
ManyToMany
snk 35
  • 18 (a)
ManyToMany
CG11670 35
  • 17 (a)
ManyToMany
CG11668 35
  • 16 (a)
ManyToMany
CG32260 35
  • 16 (a)
ManyToMany
CG31728 35
  • 13 (a)
ManyToMany
CG7432 35
  • 13 (a)
ManyToMany
Sb 35
  • 13 (a)
ManyToMany
CG6361 35
  • 12 (a)
ManyToMany
CG34350 35
  • 10 (a)
ManyToMany
CG8213 35
  • 5 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3856 35
  • 18 (a)
OneToOne
Species where no ortholog for OVCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OVCH2 Gene

ENSEMBL:
Gene Tree for OVCH2 (if available)
TreeFam:
Gene Tree for OVCH2 (if available)

Paralogs for OVCH2 Gene

genes like me logo Genes that share paralogs with OVCH2: view

Variants for OVCH2 Gene

Sequence variations from dbSNP and Humsavar for OVCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000078500 -- 7,707,281(+) GGCAC(A/C)TGGTC intron-variant, upstream-variant-2KB
rs1000227343 -- 7,708,690(+) TTAAT(A/G)TGTTC intron-variant, upstream-variant-2KB
rs1000230259 -- 7,681,910(+) TTAAA(C/T)ATGAC intron-variant
rs1000455862 -- 7,702,571(+) AATAC(C/T)TTGCA intron-variant
rs1000482087 -- 7,678,961(+) TTTTT(A/T)AATGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OVCH2 Gene

Variant ID Type Subtype PubMed ID
dgv184e214 CNV gain 21293372
esv2518653 CNV deletion 19546169
esv3891925 CNV gain 25118596
esv3891927 CNV loss 25118596
nsv1035575 CNV gain 25217958
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv951305 CNV duplication 24416366

Relevant External Links for OVCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OVCH2 Gene

Disorders for OVCH2 Gene

Relevant External Links for OVCH2

Genetic Association Database (GAD)
OVCH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVCH2

No disorders were found for OVCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCH2 Gene

Publications for OVCH2 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 64
  2. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PMID: 19557197) Heard-Costa N.L. … North K.E. (PLoS Genet. 2009) 3 46 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64

Products for OVCH2 Gene

Sources for OVCH2 Gene

Content
Loading form....