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Aliases for OVCH2 Gene

Aliases for OVCH2 Gene

  • Ovochymase 2 (Gene/Pseudogene) 2 3
  • OVTN 3 4
  • Oviductin Protease 3
  • Ovochymase 2 2
  • Ovochymase-2 3
  • EC 3.4.21.- 4
  • Oviductin 4

External Ids for OVCH2 Gene

Previous GeneCards Identifiers for OVCH2 Gene

  • GC11M007371

Summaries for OVCH2 Gene

GeneCards Summary for OVCH2 Gene

OVCH2 (Ovochymase 2 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS56.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCH2 Gene

Genomics for OVCH2 Gene

Regulatory Elements for OVCH2 Gene

Genomic Location for OVCH2 Gene

7,689,438 bp from pter
7,706,454 bp from pter
17,017 bases
Minus strand

Genomic View for OVCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCH2 Gene

Proteins for OVCH2 Gene

  • Protein details for OVCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for OVCH2 Gene

    564 amino acids
    Molecular mass:
    62642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCH2 Gene

Proteomics data for OVCH2 Gene at MOPED

Post-translational modifications for OVCH2 Gene

  • Glycosylation at Asn104, Asn415, Asn451, and Asn530
  • Modification sites at PhosphoSitePlus

Other Protein References for OVCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCH2 Gene

Domains for OVCH2 Gene

Suggested Antigen Peptide Sequences for OVCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CUB domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 CUB domains.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with OVCH2: view

No data available for Gene Families for OVCH2 Gene

Function for OVCH2 Gene

Enzyme Numbers (IUBMB) for OVCH2 Gene

Gene Ontology (GO) - Molecular Function for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVCH2: view

Phenotypes for OVCH2 Gene

GenomeRNAi human phenotypes for OVCH2:
genes like me logo Genes that share phenotypes with OVCH2: view

Animal Model Products

miRNA for OVCH2 Gene

miRTarBase miRNAs that target OVCH2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OVCH2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCH2 Gene

Localization for OVCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVCH2 Gene


Subcellular locations from

Jensen Localization Image for OVCH2 Gene COMPARTMENTS Subcellular localization image for OVCH2 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OVCH2: view

Pathways for OVCH2 Gene

SuperPathways for OVCH2 Gene

No Data Available

Interacting Proteins for OVCH2 Gene

Gene Ontology (GO) - Biological Process for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Pathways by source for OVCH2 Gene

Transcripts for OVCH2 Gene

mRNA/cDNA for OVCH2 Gene

(16) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVCH2 Gene

Ovochymase 2 (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OVCH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCH2 Gene

No ASD Table

Relevant External Links for OVCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OVCH2 Gene

mRNA expression in normal human tissues for OVCH2 Gene

mRNA differential expression in normal tissues according to GTEx for OVCH2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.9), Skin - Sun Exposed (Lower leg) (8.7), Breast - Mammary Tissue (5.2), Bladder (4.6), and Prostate (4.1).

Protein differential expression in normal tissues for OVCH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (62.8) and Platelet (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OVCH2 Gene

SOURCE GeneReport for Unigene cluster for OVCH2 Gene Hs.532475

genes like me logo Genes that share expressions with OVCH2: view

Expression partners for OVCH2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OVCH2 Gene

Orthologs for OVCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OVCH2 35
  • 84.16 (n)
  • 76.8 (a)
OVCH2 36
  • 72 (a)
(Canis familiaris)
Mammalia OVCH2 35
  • 84.31 (n)
  • 78.79 (a)
OVCH2 36
  • 76 (a)
(Mus musculus)
Mammalia Ovch2 35
  • 82.5 (n)
  • 77.58 (a)
Ovch2 16
Ovch2 36
  • 70 (a)
(Pan troglodytes)
Mammalia OVCH2 35
  • 99 (n)
  • 97.7 (a)
OVCH2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ovch2 35
  • 83.6 (n)
  • 78.25 (a)
(Monodelphis domestica)
Mammalia OVCH2 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia OVCH2 36
  • 56 (a)
(Gallus gallus)
Aves OVCH2 35
  • 65.13 (n)
  • 56.54 (a)
OVCH2 36
  • 37 (a)
(Anolis carolinensis)
Reptilia OVCH2 36
  • 35 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398108 35
(Danio rerio)
Actinopterygii LOC101884131 35
  • 48.49 (n)
  • 40.65 (a)
ovch2 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11668 36
  • 16 (a)
CG11670 36
  • 17 (a)
CG11836 36
  • 32 (a)
CG11841 36
  • 21 (a)
CG11842 36
  • 19 (a)
CG11843 36
  • 23 (a)
CG1299 36
  • 18 (a)
CG14642 36
  • 20 (a)
CG14892 36
  • 18 (a)
CG18735 36
  • 28 (a)
CG31728 36
  • 13 (a)
CG32260 36
  • 16 (a)
CG3355 36
  • 28 (a)
CG34350 36
  • 10 (a)
CG3700 36
  • 21 (a)
CG4386 36
  • 25 (a)
CG4613 36
  • 23 (a)
CG4914 36
  • 27 (a)
CG4927 36
  • 22 (a)
CG6361 36
  • 12 (a)
CG6865 36
  • 28 (a)
CG7432 36
  • 13 (a)
CG8172 36
  • 18 (a)
CG8213 36
  • 5 (a)
CG9294 36
  • 23 (a)
CG9372 36
  • 21 (a)
psh 36
  • 18 (a)
Sb 36
  • 13 (a)
snk 36
  • 18 (a)
spirit 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3856 36
  • 18 (a)
Species with no ortholog for OVCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OVCH2 Gene

Gene Tree for OVCH2 (if available)
Gene Tree for OVCH2 (if available)

Paralogs for OVCH2 Gene

Paralogs for OVCH2 Gene

genes like me logo Genes that share paralogs with OVCH2: view

Variants for OVCH2 Gene

Sequence variations from dbSNP and Humsavar for OVCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs181061521 -- 7,695,563(+) AAATG(C/G)TTTTA intron-variant
rs180932936 -- 7,693,377(+) TCTCC(A/G)AGTCA intron-variant
rs180923137 -- 7,700,397(+) AGCCT(C/T)GACCA missense, reference
rs150603993 -- 7,698,135(+) TTGCA(C/G)CTTCA intron-variant
rs150335568 -- 7,694,611(+) TTTTT(-/GTTT/T/TT)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OVCH2 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2518653 CNV Deletion 19546169
nsv512206 CNV Loss 21212237
esv2164871 CNV Deletion 18987734
esv5220 CNV Deletion 18987735
esv2540661 CNV Deletion 19546169
dgv19n6 CNV Loss 16902084
esv990602 CNV Deletion 20482838
esv9107 CNV Loss 19470904
esv1223356 CNV Deletion 17803354
esv2744080 CNV Deletion 23290073

Relevant External Links for OVCH2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVCH2 Gene

Disorders for OVCH2 Gene

Relevant External Links for OVCH2

Genetic Association Database (GAD)

No disorders were found for OVCH2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OVCH2 Gene

Publications for OVCH2 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  3. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PMID: 19557197) Heard-Costa N.L. … North K.E. (PLoS Genet. 2009) 3 48

Products for OVCH2 Gene

Sources for OVCH2 Gene

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