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Aliases for OVCH1 Gene

Aliases for OVCH1 Gene

  • Ovochymase 1 2 3 5
  • Ovochymase-1 3
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • OVCH 3

External Ids for OVCH1 Gene

Previous GeneCards Identifiers for OVCH1 Gene

  • GC12M029476
  • GC12U900395
  • GC12M029471
  • GC12M029580

Summaries for OVCH1 Gene

GeneCards Summary for OVCH1 Gene

OVCH1 (Ovochymase 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is OVCH2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCH1 Gene

Genomics for OVCH1 Gene

Regulatory Elements for OVCH1 Gene

Enhancers for OVCH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OVCH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OVCH1 Gene

29,412,474 bp from pter
29,497,800 bp from pter
85,327 bases
Minus strand

Genomic View for OVCH1 Gene

Genes around OVCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCH1 Gene

Proteins for OVCH1 Gene

  • Protein details for OVCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for OVCH1 Gene

    1134 amino acids
    Molecular mass:
    125066 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCH1 Gene

Selected DME Specific Peptides for OVCH1 Gene

Post-translational modifications for OVCH1 Gene

  • Glycosylation at Asn 52, Asn 99, Asn 324, Asn 431, Asn 507, and Asn 1106
  • Modification sites at PhosphoSitePlus

Other Protein References for OVCH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for OVCH1 Gene

Suggested Antigen Peptide Sequences for OVCH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 CUB domains.
  • Belongs to the peptidase S1 family.
  • Contains 3 CUB domains.
  • Contains 2 peptidase S1 domains.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with OVCH1: view

No data available for Gene Families for OVCH1 Gene

Function for OVCH1 Gene

Enzyme Numbers (IUBMB) for OVCH1 Gene

Gene Ontology (GO) - Molecular Function for OVCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVCH1: view
genes like me logo Genes that share phenotypes with OVCH1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVCH1 Gene

Localization for OVCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVCH1 Gene


Subcellular locations from

Jensen Localization Image for OVCH1 Gene COMPARTMENTS Subcellular localization image for OVCH1 gene
Compartment Confidence
extracellular 4
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for OVCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OVCH1: view

Pathways & Interactions for OVCH1 Gene

SuperPathways for OVCH1 Gene

No Data Available

Interacting Proteins for OVCH1 Gene

Selected Interacting proteins: Q7RTY7-OVCH1_HUMAN for OVCH1 Gene via IID

Gene Ontology (GO) - Biological Process for OVCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OVCH1: view

No data available for Pathways by source and SIGNOR curated interactions for OVCH1 Gene

Drugs & Compounds for OVCH1 Gene

No Compound Related Data Available

Transcripts for OVCH1 Gene

mRNA/cDNA for OVCH1 Gene

(8) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVCH1 Gene

Ovochymase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCH1 Gene

No ASD Table

Relevant External Links for OVCH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OVCH1 Gene

mRNA expression in normal human tissues for OVCH1 Gene

mRNA differential expression in normal tissues according to GTEx for OVCH1 Gene

This gene is overexpressed in Testis (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVCH1 Gene

Protein tissue co-expression partners for OVCH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCH1 Gene:


SOURCE GeneReport for Unigene cluster for OVCH1 Gene:

genes like me logo Genes that share expression patterns with OVCH1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OVCH1 Gene

Orthologs for OVCH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVCH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OVCH1 34
  • 80.69 (n)
  • 70.74 (a)
OVCH1 35
  • 60 (a)
(Pan troglodytes)
Mammalia OVCH1 34
  • 98.27 (n)
  • 97.5 (a)
OVCH1 35
  • 97 (a)
(Canis familiaris)
Mammalia OVCH1 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia OVCH1 35
  • 35 (a)
(Anolis carolinensis)
Reptilia OVCH1 35
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ovch1 34
  • 51.31 (n)
  • 39.18 (a)
(Danio rerio)
Actinopterygii zgc:55888 34
  • 44.95 (n)
  • 34.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11668 35
  • 19 (a)
CG11670 35
  • 19 (a)
CG11836 35
  • 34 (a)
CG11841 35
  • 20 (a)
CG11842 35
  • 22 (a)
CG11843 35
  • 23 (a)
CG1299 35
  • 22 (a)
CG14642 35
  • 23 (a)
CG14892 35
  • 22 (a)
CG18735 35
  • 30 (a)
CG31728 35
  • 22 (a)
CG32260 35
  • 19 (a)
CG3355 35
  • 31 (a)
CG34350 35
  • 14 (a)
CG3700 35
  • 22 (a)
CG4386 35
  • 27 (a)
CG4613 35
  • 28 (a)
CG4914 35
  • 31 (a)
CG4927 35
  • 21 (a)
CG6361 35
  • 17 (a)
CG6865 35
  • 28 (a)
CG7432 35
  • 18 (a)
CG8172 35
  • 18 (a)
CG8213 35
  • 9 (a)
CG9294 35
  • 30 (a)
CG9372 35
  • 24 (a)
psh 35
  • 20 (a)
Sb 35
  • 16 (a)
snk 35
  • 19 (a)
spirit 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6617 35
  • 34 (a)
Species where no ortholog for OVCH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OVCH1 Gene

Gene Tree for OVCH1 (if available)
Gene Tree for OVCH1 (if available)

Paralogs for OVCH1 Gene

Paralogs for OVCH1 Gene

genes like me logo Genes that share paralogs with OVCH1: view

Variants for OVCH1 Gene

Sequence variations from dbSNP and Humsavar for OVCH1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10843438 - 29,495,342(+) TTCAC(A/G)GCTGT nc-transcript-variant, reference, missense
rs967181 - 29,489,640(-) CTGAT(G/T)GGGGA nc-transcript-variant, reference, missense
VAR_029091 -
VAR_029092 -
VAR_029093 -

Structural Variations from Database of Genomic Variants (DGV) for OVCH1 Gene

Variant ID Type Subtype PubMed ID
esv3580214 CNV loss 25503493
nsv469190 CNV gain 19166990
nsv525100 CNV loss 19592680
nsv527807 CNV loss 19592680
nsv557917 CNV gain 21841781

Variation tolerance for OVCH1 Gene

Gene Damage Index Score: 13.51; 95.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVCH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVCH1 Gene

Disorders for OVCH1 Gene

Relevant External Links for OVCH1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OVCH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCH1 Gene

Publications for OVCH1 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 65
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 65
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 65

Products for OVCH1 Gene

Sources for OVCH1 Gene

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