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Aliases for OVCA2 Gene

Aliases for OVCA2 Gene

  • OVCA2, Serine Hydrolase Domain Containing 2 3 5
  • Candidate Tumor Suppressor In Ovarian Cancer 2 2
  • Ovarian Cancer-Associated Gene 2 Protein 4
  • Ovarian Tumor Suppressor Candidate 2 2
  • EC 3.1.2.- 4

External Ids for OVCA2 Gene

Previous GeneCards Identifiers for OVCA2 Gene

  • GC17U990304
  • GC17P002273
  • GC17P001884
  • GC17P002151
  • GC17P001892
  • GC17P001945

Summaries for OVCA2 Gene

GeneCards Summary for OVCA2 Gene

OVCA2 (OVCA2, Serine Hydrolase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

Additional gene information for OVCA2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCA2 Gene

Genomics for OVCA2 Gene

Regulatory Elements for OVCA2 Gene

Enhancers for OVCA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H002170 3.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.3 +135.6 135563 13 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 YY1 ZNF121 FOS KLF7 ATF7 SRR ENSG00000236838 HIC1 ENSG00000236457 LOC101927839 OVCA2 SNORD91B SNORD91A SMG6 DPH1
GH17H002080 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +45.6 45627 13 PKNOX1 ATF1 FOXA2 SIN3A FEZF1 ZNF766 GATA2 ZNF143 ZNF207 FOS SRR HIC1 OVCA2 LOC101927839 ENSG00000236838 ENSG00000236457 SMG6 DPH1 SLC43A2 SCARF1
GH17H002261 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +223.2 223154 7 PKNOX1 FEZF1 ZNF2 ZNF207 FOS ATF7 RUNX3 ZNF491 ZNF592 ZNF624 SRR HNRNPA1P16 SMG6 METTL16 DPH1 ENSG00000263345 TSR1 ENSG00000263050 MNT LOC105371592
GH17H002235 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +196.7 196738 7 PKNOX1 TBL1XR1 ZSCAN4 BATF RAD21 RFX5 ZNF143 FOS ATF7 RUNX3 SRR HIC1 ENSG00000236457 ENSG00000236838 OVCA2 DPH1 TSR1 SGSM2 SMG6-IT1 ENSG00000280242
GH17H002136 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +96.1 96140 3 PKNOX1 FEZF1 ZNF2 GATA2 FOS KLF7 RUNX3 JUNB TSHZ1 ZNF623 ENSG00000236838 HIC1 OVCA2 SGSM2 TSR1 SCARF1 SRR WDR81 PAFAH1B1 CCDC90AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OVCA2 on UCSC Golden Path with GeneCards custom track

Promoters for OVCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090178 264 1201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 SLC30A9

Genomic Location for OVCA2 Gene

Chromosome:
17
Start:
2,041,936 bp from pter
End:
2,043,431 bp from pter
Size:
1,496 bases
Orientation:
Plus strand

Genomic View for OVCA2 Gene

Genes around OVCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCA2 Gene

Proteins for OVCA2 Gene

  • Protein details for OVCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ82-OVCA2_HUMAN
    Recommended name:
    Esterase OVCA2
    Protein Accession:
    Q8WZ82
    Secondary Accessions:
    • Q86XN3
    • Q8IW87
    • Q9UCX9

    Protein attributes for OVCA2 Gene

    Size:
    227 amino acids
    Molecular mass:
    24418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCA2 Gene

Post-translational modifications for OVCA2 Gene

  • Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCA2 Gene

Domains & Families for OVCA2 Gene

Gene Families for OVCA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OVCA2 Gene

Suggested Antigen Peptide Sequences for OVCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ82

UniProtKB/Swiss-Prot:

OVCA2_HUMAN :
  • Belongs to the LovG family.
Family:
  • Belongs to the LovG family.
genes like me logo Genes that share domains with OVCA2: view

Function for OVCA2 Gene

Molecular function for OVCA2 Gene

GENATLAS Biochemistry:
ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1

Enzyme Numbers (IUBMB) for OVCA2 Gene

Phenotypes From GWAS Catalog for OVCA2 Gene

Gene Ontology (GO) - Molecular Function for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity NAS 11979432
genes like me logo Genes that share ontologies with OVCA2: view
genes like me logo Genes that share phenotypes with OVCA2: view

Animal Model Products

CRISPR Products

miRNA for OVCA2 Gene

miRTarBase miRNAs that target OVCA2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OVCA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCA2 Gene

Localization for OVCA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OVCA2 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 16368187
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OVCA2 Gene

Pathways & Interactions for OVCA2 Gene

SuperPathways for OVCA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IDA 11979432
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Pathways by source and SIGNOR curated interactions for OVCA2 Gene

Drugs & Compounds for OVCA2 Gene

No Compound Related Data Available

Transcripts for OVCA2 Gene

mRNA/cDNA for OVCA2 Gene

(1) REFSEQ mRNAs :
(384) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OVCA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OVCA2 Gene

No ASD Table

Relevant External Links for OVCA2 Gene

GeneLoc Exon Structure for
OVCA2
ECgene alternative splicing isoforms for
OVCA2

Expression for OVCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVCA2 Gene

Protein differential expression in normal tissues from HIPED for OVCA2 Gene

This gene is overexpressed in Liver (9.9) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OVCA2 Gene



Protein tissue co-expression partners for OVCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCA2 Gene:

OVCA2

mRNA Expression by UniProt/SwissProt for OVCA2 Gene:

Q8WZ82-OVCA2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for OVCA2 Gene

  • Intestine(4)
  • Liver(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with OVCA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVCA2 Gene

Orthologs for OVCA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCA2 33 34
  • 84.73 (n)
dog
(Canis familiaris)
Mammalia OVCA2 33
  • 84.73 (n)
DPH1 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovca2 33 16 34
  • 84 (n)
rat
(Rattus norvegicus)
Mammalia Ovca2 33
  • 82.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OVCA2 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCA2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves OVCA2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovca2 33
  • 56.01 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333950 33
  • 49.46 (n)
ovca2 34
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5412 35 33 34
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta U483_ANOGA 33
  • 47.85 (n)
worm
(Caenorhabditis elegans)
Secernentea C25G4.2 35 33 34
  • 46.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSH1 34
  • 21 (a)
OneToOne
Species where no ortholog for OVCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVCA2 Gene

ENSEMBL:
Gene Tree for OVCA2 (if available)
TreeFam:
Gene Tree for OVCA2 (if available)

Paralogs for OVCA2 Gene

No data available for Paralogs for OVCA2 Gene

Variants for OVCA2 Gene

Sequence variations from dbSNP and Humsavar for OVCA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000112259 -- 2,042,402(+) GTCCT(C/T)CCAGG intron-variant
rs1000148954 -- 2,043,466(+) CATTT(G/T)ATAAT downstream-variant-500B
rs1000201625 -- 2,043,215(+) CAGAA(C/G)CAGTT nc-transcript-variant, utr-variant-3-prime
rs1000484055 -- 2,042,483(+) CCCCC(A/C)GACTT intron-variant
rs1001146133 -- 2,041,581(+) CCAGG(A/G)CCGCC nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OVCA2 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV loss 17666407
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138

Variation tolerance for OVCA2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVCA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVCA2 Gene

Disorders for OVCA2 Gene

Relevant External Links for OVCA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVCA2

No disorders were found for OVCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCA2 Gene

Publications for OVCA2 Gene

  1. OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PMID: 11979432) Prowse AH … Godwin AK (International journal of cancer 2002) 2 3 4 22 60
  2. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PMID: 8616839) Schultz DC … Godwin AK (Cancer research 1996) 2 3 4 60
  3. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PMID: 16368187) Azizi AA … Lubec G (Cancer letters 2006) 2 3 60
  4. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. (PMID: 14645503) Baxter SM … Fetrow JS (Molecular & cellular proteomics : MCP 2004) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for OVCA2 Gene

Sources for OVCA2 Gene

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