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Aliases for OVCA2 Gene

Aliases for OVCA2 Gene

  • Ovarian Tumor Suppressor Candidate 2 2 3
  • Candidate Tumor Suppressor In Ovarian Cancer 2 2

External Ids for OVCA2 Gene

Previous GeneCards Identifiers for OVCA2 Gene

  • GC17U990304
  • GC17P002273
  • GC17P001884
  • GC17P002151
  • GC17P001892
  • GC17P001945

Summaries for OVCA2 Gene

GeneCards Summary for OVCA2 Gene

OVCA2 (Ovarian Tumor Suppressor Candidate 2) is a Protein Coding gene. Diseases associated with OVCA2 include intrahepatic cholangiocarcinoma. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCA2 Gene

Genomics for OVCA2 Gene

Regulatory Elements for OVCA2 Gene

Genomic Location for OVCA2 Gene

Start:
2,041,936 bp from pter
End:
2,043,431 bp from pter
Size:
1,496 bases
Orientation:
Plus strand

Genomic View for OVCA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCA2 Gene

Proteins for OVCA2 Gene

  • Protein details for OVCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ82-OVCA2_HUMAN
    Recommended name:
    Ovarian cancer-associated gene 2 protein
    Protein Accession:
    Q8WZ82
    Secondary Accessions:
    • Q86XN3
    • Q8IW87
    • Q9UCX9

    Protein attributes for OVCA2 Gene

    Size:
    227 amino acids
    Molecular mass:
    24418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCA2 Gene

Proteomics data for OVCA2 Gene at MOPED

Post-translational modifications for OVCA2 Gene

  • Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCA2 Gene

Domains for OVCA2 Gene

Protein Domains for OVCA2 Gene

Suggested Antigen Peptide Sequences for OVCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ82

UniProtKB/Swiss-Prot:

OVCA2_HUMAN :
  • Q8WZ82
Family:
  • Belongs to the UPF0483 (OVCA2) family.
genes like me logo Genes that share domains with OVCA2: view

No data available for Gene Families for OVCA2 Gene

Function for OVCA2 Gene

Molecular function for OVCA2 Gene

GENATLAS Biochemistry: ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1

Gene Ontology (GO) - Molecular Function for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity NAS 11979432
genes like me logo Genes that share ontologies with OVCA2: view

Animal Model Products

CRISPR Products

miRNA for OVCA2 Gene

miRTarBase miRNAs that target OVCA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OVCA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OVCA2 Gene

Localization for OVCA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVCA2 Gene COMPARTMENTS Subcellular localization image for OVCA2 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 16368187
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OVCA2 Gene

Pathways for OVCA2 Gene

SuperPathways for OVCA2 Gene

No Data Available

Interacting Proteins for OVCA2 Gene

Gene Ontology (GO) - Biological Process for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process NAS 11979432
GO:0032526 response to retinoic acid IDA 11979432
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Pathways by source for OVCA2 Gene

Transcripts for OVCA2 Gene

mRNA/cDNA for OVCA2 Gene

(384) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OVCA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCA2 Gene

No ASD Table

Relevant External Links for OVCA2 Gene

GeneLoc Exon Structure for
OVCA2
ECgene alternative splicing isoforms for
OVCA2

Expression for OVCA2 Gene

mRNA expression in normal human tissues for OVCA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OVCA2 Gene

mRNA Expression by UniProt/SwissProt for OVCA2 Gene

Q8WZ82-OVCA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with OVCA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OVCA2 Gene

Orthologs for OVCA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCA2 35
  • 84.73 (n)
  • 84.58 (a)
OVCA2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH1 36
  • 83 (a)
OneToOne
OVCA2 35
  • 84.73 (n)
  • 83.26 (a)
mouse
(Mus musculus)
Mammalia Ovca2 35
  • 84 (n)
  • 84 (a)
Ovca2 16
Ovca2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCA2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVCA2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ovca2 35
  • 82.38 (n)
  • 83.26 (a)
chicken
(Gallus gallus)
Aves OVCA2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovca2 35
  • 56.01 (n)
  • 53.88 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333950 35
  • 49.46 (n)
  • 49.3 (a)
ovca2 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta U483_ANOGA 35
  • 47.85 (n)
  • 35.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5412 35
  • 48.93 (n)
  • 39.41 (a)
CG5412 36
  • 28 (a)
OneToOne
CG5412 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea C25G4.2 35
  • 46.09 (n)
  • 38.28 (a)
C25G4.2 36
  • 38 (a)
OneToOne
C25G4.2 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSH1 36
  • 21 (a)
OneToOne
Species with no ortholog for OVCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVCA2 Gene

ENSEMBL:
Gene Tree for OVCA2 (if available)
TreeFam:
Gene Tree for OVCA2 (if available)

Paralogs for OVCA2 Gene

No data available for Paralogs for OVCA2 Gene

Variants for OVCA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OVCA2 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV Loss 17666407
nsv907523 CNV Loss 21882294
dgv3034n71 CNV Loss 21882294
nsv827857 CNV Gain 20364138
nsv907526 CNV Loss 21882294
dgv3035n71 CNV Loss 21882294

Relevant External Links for OVCA2 Gene

HapMap Linkage Disequilibrium report
OVCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OVCA2 Gene

Disorders for OVCA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OVCA2 Gene including...

Search for OVCA2 Gene in MalaCards »
genes like me logo Genes that share disorders with OVCA2: view

No data available for UniProtKB/Swiss-Prot for OVCA2 Gene

Publications for OVCA2 Gene

  1. OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PMID: 11979432) Prowse A.H. … Godwin A.K. (Int. J. Cancer 2002) 2 3 4 23
  2. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PMID: 8616839) Schultz D.C. … Godwin A.K. (Cancer Res. 1996) 2 3 4
  3. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PMID: 16368187) Azizi A.A. … Lubec G. (Cancer Lett. 2006) 2 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for OVCA2 Gene

Sources for OVCA2 Gene

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