Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OVCA2 Gene

Aliases for OVCA2 Gene

  • Ovarian Tumor Suppressor Candidate 2 2 3 5
  • Candidate Tumor Suppressor In Ovarian Cancer 2 2

External Ids for OVCA2 Gene

Previous GeneCards Identifiers for OVCA2 Gene

  • GC17U990304
  • GC17P002273
  • GC17P001884
  • GC17P002151
  • GC17P001892
  • GC17P001945

Summaries for OVCA2 Gene

GeneCards Summary for OVCA2 Gene

OVCA2 (Ovarian Tumor Suppressor Candidate 2) is a Protein Coding gene. Diseases associated with OVCA2 include ovarian cancer. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCA2 Gene

Genomics for OVCA2 Gene

Regulatory Elements for OVCA2 Gene

Promoters for OVCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OVCA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OVCA2 Gene

Chromosome:
17
Start:
2,041,936 bp from pter
End:
2,043,431 bp from pter
Size:
1,496 bases
Orientation:
Plus strand

Genomic View for OVCA2 Gene

Genes around OVCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCA2 Gene

Proteins for OVCA2 Gene

  • Protein details for OVCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ82-OVCA2_HUMAN
    Recommended name:
    Ovarian cancer-associated gene 2 protein
    Protein Accession:
    Q8WZ82
    Secondary Accessions:
    • Q86XN3
    • Q8IW87
    • Q9UCX9

    Protein attributes for OVCA2 Gene

    Size:
    227 amino acids
    Molecular mass:
    24418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCA2 Gene

Proteomics data for OVCA2 Gene at MOPED

Post-translational modifications for OVCA2 Gene

  • Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCA2 Gene

Domains & Families for OVCA2 Gene

Protein Domains for OVCA2 Gene

Suggested Antigen Peptide Sequences for OVCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ82

UniProtKB/Swiss-Prot:

OVCA2_HUMAN :
  • Belongs to the UPF0483 (OVCA2) family.
Family:
  • Belongs to the UPF0483 (OVCA2) family.
genes like me logo Genes that share domains with OVCA2: view

No data available for Gene Families for OVCA2 Gene

Function for OVCA2 Gene

Molecular function for OVCA2 Gene

GENATLAS Biochemistry:
ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1
genes like me logo Genes that share phenotypes with OVCA2: view

Animal Model Products

miRNA for OVCA2 Gene

miRTarBase miRNAs that target OVCA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCA2 Gene

Localization for OVCA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVCA2 Gene COMPARTMENTS Subcellular localization image for OVCA2 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OVCA2 Gene

Pathways & Interactions for OVCA2 Gene

SuperPathways for OVCA2 Gene

No Data Available

Interacting Proteins for OVCA2 Gene

Gene Ontology (GO) - Biological Process for OVCA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OVCA2 Gene

Drugs & Compounds for OVCA2 Gene

No Compound Related Data Available

Transcripts for OVCA2 Gene

mRNA/cDNA for OVCA2 Gene

(1) REFSEQ mRNAs :
(384) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OVCA2 Gene

No ASD Table

Relevant External Links for OVCA2 Gene

GeneLoc Exon Structure for
OVCA2
ECgene alternative splicing isoforms for
OVCA2

Expression for OVCA2 Gene

mRNA expression in normal human tissues for OVCA2 Gene

Protein differential expression in normal tissues from HIPED for OVCA2 Gene

This gene is overexpressed in Liver (9.9) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OVCA2 Gene



mRNA Expression by UniProt/SwissProt for OVCA2 Gene

Q8WZ82-OVCA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with OVCA2: view

Protein tissue co-expression partners for OVCA2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OVCA2 Gene

Orthologs for OVCA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCA2 36
  • 85 (a)
OneToOne
OVCA2 35
  • 84.73 (n)
  • 84.58 (a)
dog
(Canis familiaris)
Mammalia OVCA2 35
  • 84.73 (n)
  • 83.26 (a)
DPH1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovca2 35
  • 84 (n)
  • 84 (a)
Ovca2 16
Ovca2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCA2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVCA2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ovca2 35
  • 82.38 (n)
  • 83.26 (a)
chicken
(Gallus gallus)
Aves OVCA2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovca2 35
  • 56.01 (n)
  • 53.88 (a)
zebrafish
(Danio rerio)
Actinopterygii ovca2 36
  • 47 (a)
OneToOne
LOC100333950 35
  • 49.46 (n)
  • 49.3 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta U483_ANOGA 35
  • 47.85 (n)
  • 35.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5412 36
  • 28 (a)
OneToOne
CG5412 37
  • 36 (a)
CG5412 35
  • 48.93 (n)
  • 39.41 (a)
worm
(Caenorhabditis elegans)
Secernentea C25G4.2 35
  • 46.09 (n)
  • 38.28 (a)
C25G4.2 37
  • 35 (a)
C25G4.2 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSH1 36
  • 21 (a)
OneToOne
Species with no ortholog for OVCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVCA2 Gene

ENSEMBL:
Gene Tree for OVCA2 (if available)
TreeFam:
Gene Tree for OVCA2 (if available)

Paralogs for OVCA2 Gene

No data available for Paralogs for OVCA2 Gene

Variants for OVCA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OVCA2 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV Loss 17666407
nsv907523 CNV Loss 21882294
dgv3034n71 CNV Loss 21882294
nsv827857 CNV Gain 20364138
nsv907526 CNV Loss 21882294
dgv3035n71 CNV Loss 21882294

Variation tolerance for OVCA2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVCA2 Gene

HapMap Linkage Disequilibrium report
OVCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OVCA2 Gene

Disorders for OVCA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OVCA2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards
Search OVCA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OVCA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVCA2
genes like me logo Genes that share disorders with OVCA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OVCA2 Gene

Publications for OVCA2 Gene

  1. OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PMID: 11979432) Prowse A.H. … Godwin A.K. (Int. J. Cancer 2002) 2 3 4 23 67
  2. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PMID: 16368187) Azizi A.A. … Lubec G. (Cancer Lett. 2006) 2 3
  3. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PMID: 8616839) Schultz D.C. … Godwin A.K. (Cancer Res. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for OVCA2 Gene

Sources for OVCA2 Gene

Back to Top

Content