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Aliases for OVCA2 Gene

Aliases for OVCA2 Gene

  • Ovarian Tumor Suppressor Candidate 2 2 3 5
  • Candidate Tumor Suppressor In Ovarian Cancer 2 2
  • Ovarian Cancer-Associated Gene 2 Protein 4
  • EC 3.1.2.- 4

External Ids for OVCA2 Gene

Previous GeneCards Identifiers for OVCA2 Gene

  • GC17U990304
  • GC17P002273
  • GC17P001884
  • GC17P002151
  • GC17P001892
  • GC17P001945

Summaries for OVCA2 Gene

GeneCards Summary for OVCA2 Gene

OVCA2 (Ovarian Tumor Suppressor Candidate 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCA2 Gene

Genomics for OVCA2 Gene

Regulatory Elements for OVCA2 Gene

Enhancers for OVCA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F002080 1.7 FANTOM5 Ensembl ENCODE 12.2 +45.6 45627 13.2 PKNOX1 WRNIP1 SIN3A FEZF1 ZNF766 ZNF143 FOS ZNF263 JUNB REST SRR HIC1 OVCA2 LOC101927839 LOC105371487 ENSG00000236457 SMG6 SLC43A2 SCARF1 WDR81
GH17F002095 1.2 Ensembl ENCODE 12.1 +53.3 53261 1.2 ARID4B ZNF48 YY1 ZNF143 ZNF263 SP5 REST MIER2 PPARG KAT8 HIC1 OVCA2 LOC105371487 ENSG00000236457 DPH1 ENSG00000262810 GC17P002103
GH17F002120 0.9 Ensembl ENCODE 11.9 +78.9 78883 0.8 CTCF ZNF211 ZNF146 SUZ12 ZNF223 SIN3A ZIC2 ZNF335 HIC1 ZNF316 LOC105371487 HIC1 OVCA2 ENSG00000236457 ENSG00000263345 SGSM2 TSR1 ENSG00000279340 ENSG00000279562 GC17M002124
GH17F002094 0.6 ENCODE 11.8 +52.3 52260 0.0 SAP130 INSM2 KLF17 SIN3A ZKSCAN1 ZNF664 HIC1 ZNF366 SCRT2 ZNF600 HIC1 OVCA2 LOC105371487 ENSG00000236457 ENSG00000262810 GC17P002103
GH17F002258 1.4 FANTOM5 Ensembl ENCODE 11.8 +217.7 217663 2.9 PKNOX1 EBF1 ZBTB40 RELA POLR2A EED ZNF207 ETV6 CREM MTA2 SRR SMG6 OVCA2 HIC1 ENSG00000236457 LOC105371487 SNORD91B SNORD91A SMYD4 METTL16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OVCA2 on UCSC Golden Path with GeneCards custom track

Promoters for OVCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001338949 164 1401 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1

Genomic Location for OVCA2 Gene

Chromosome:
17
Start:
2,041,936 bp from pter
End:
2,043,431 bp from pter
Size:
1,496 bases
Orientation:
Plus strand

Genomic View for OVCA2 Gene

Genes around OVCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCA2 Gene

Proteins for OVCA2 Gene

  • Protein details for OVCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ82-OVCA2_HUMAN
    Recommended name:
    Esterase OVCA2
    Protein Accession:
    Q8WZ82
    Secondary Accessions:
    • Q86XN3
    • Q8IW87
    • Q9UCX9

    Protein attributes for OVCA2 Gene

    Size:
    227 amino acids
    Molecular mass:
    24418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCA2 Gene

Post-translational modifications for OVCA2 Gene

  • Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCA2 Gene

Domains & Families for OVCA2 Gene

Protein Domains for OVCA2 Gene

Suggested Antigen Peptide Sequences for OVCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ82

UniProtKB/Swiss-Prot:

OVCA2_HUMAN :
  • Belongs to the LovG family.
Family:
  • Belongs to the LovG family.
genes like me logo Genes that share domains with OVCA2: view

No data available for Gene Families for OVCA2 Gene

Function for OVCA2 Gene

Molecular function for OVCA2 Gene

GENATLAS Biochemistry:
ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1

Enzyme Numbers (IUBMB) for OVCA2 Gene

Gene Ontology (GO) - Molecular Function for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity NAS 11979432
genes like me logo Genes that share ontologies with OVCA2: view
genes like me logo Genes that share phenotypes with OVCA2: view

Animal Model Products

miRNA for OVCA2 Gene

miRTarBase miRNAs that target OVCA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCA2 Gene

Localization for OVCA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVCA2 Gene COMPARTMENTS Subcellular localization image for OVCA2 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 16368187
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OVCA2 Gene

Pathways & Interactions for OVCA2 Gene

SuperPathways for OVCA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IDA 11979432
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Pathways by source and SIGNOR curated interactions for OVCA2 Gene

Transcripts for OVCA2 Gene

mRNA/cDNA for OVCA2 Gene

(1) REFSEQ mRNAs :
(384) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCA2 Gene

No ASD Table

Relevant External Links for OVCA2 Gene

GeneLoc Exon Structure for
OVCA2
ECgene alternative splicing isoforms for
OVCA2

Expression for OVCA2 Gene

mRNA expression in normal human tissues for OVCA2 Gene

Protein differential expression in normal tissues from HIPED for OVCA2 Gene

This gene is overexpressed in Liver (9.9) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OVCA2 Gene



Protein tissue co-expression partners for OVCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCA2 Gene:

OVCA2

mRNA Expression by UniProt/SwissProt for OVCA2 Gene:

Q8WZ82-OVCA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with OVCA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OVCA2 Gene

Orthologs for OVCA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCA2 34 35
  • 84.73 (n)
dog
(Canis familiaris)
Mammalia OVCA2 34
  • 84.73 (n)
DPH1 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovca2 34 16 35
  • 84 (n)
rat
(Rattus norvegicus)
Mammalia Ovca2 34
  • 82.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OVCA2 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCA2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves OVCA2 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovca2 34
  • 56.01 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333950 34
  • 49.46 (n)
ovca2 35
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5412 36 34 35
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta U483_ANOGA 34
  • 47.85 (n)
worm
(Caenorhabditis elegans)
Secernentea C25G4.2 36 34 35
  • 46.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSH1 35
  • 21 (a)
OneToOne
Species where no ortholog for OVCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVCA2 Gene

ENSEMBL:
Gene Tree for OVCA2 (if available)
TreeFam:
Gene Tree for OVCA2 (if available)

Paralogs for OVCA2 Gene

No data available for Paralogs for OVCA2 Gene

Variants for OVCA2 Gene

Sequence variations from dbSNP and Humsavar for OVCA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1051322 -- 2,043,209(+) CCTCA(C/G)CAGAA utr-variant-3-prime
rs112492347 -- 2,040,759(+) TCATA(C/G)CTGCT intron-variant, upstream-variant-2KB
rs112763188 -- 2,040,096(+) CCTCT(C/G)TTCTT intron-variant, upstream-variant-2KB
rs113084028 -- 2,040,136(+) GAGCC(C/T)ACGGG intron-variant, upstream-variant-2KB
rs113371792 -- 2,042,611(+) GTCCT(A/G/T)CCCTC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OVCA2 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV loss 17666407
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138

Variation tolerance for OVCA2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVCA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVCA2 Gene

Disorders for OVCA2 Gene

Relevant External Links for OVCA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVCA2

No disorders were found for OVCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCA2 Gene

Publications for OVCA2 Gene

  1. OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PMID: 11979432) Prowse A.H. … Godwin A.K. (Int. J. Cancer 2002) 2 3 4 22 64
  2. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PMID: 8616839) Schultz D.C. … Godwin A.K. (Cancer Res. 1996) 2 3 4 64
  3. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PMID: 16368187) Azizi A.A. … Lubec G. (Cancer Lett. 2006) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for OVCA2 Gene

Sources for OVCA2 Gene

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