OVCA2 Gene
protein-coding GIFtS: 40
GCID: GC17P001945
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|
ovarian tumor suppressor candidate 2
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Aliases
for OVCA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ovarian Tumor Suppressor Candidate 21 2 | | Candidate Tumor Suppressor In Ovarian Cancer 22 | | Ovarian Cancer Gene-2 Protein2 | | Ovarian Cancer-Associated Gene 2 Protein2 |
Export aliases for OVCA2 gene to outside databasesPrevious GC identifers: GC17U990304 GC17P002273 GC17P001884 GC17P002151 GC17P001892 |
Summaries
for OVCA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for OVCA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OVCA2 gene promoter:
c-Fos Max1 NF-1 AP-1 GATA-2 HOXA5 Chx10 c-Jun NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OVCA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVCA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3OVCA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P001945: view genomic region
(about GC identifiers)
Start:
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1,945,277 bp from pter |
End:
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1,946,725 bp from pter |
Size:
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1,449 bases |
Orientation:
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plus strand |
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Proteins
for OVCA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OVCA2_HUMAN, Q8WZ82 (See
protein sequence)Recommended Name: Ovarian cancer-associated gene 2 protein Size: 227 amino acids; 24418 Da
Caution: Encoded in an intron of the gene DPH1/OVCA1 (same strand)
Secondary accessions: Q86XN3 Q8IW87 Q9UCX9Explore the universe of human proteins at neXtProt for OVCA2: NX_Q8WZ82
Post-translational modifications:
Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocyticleukemia cell line HL-601
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WZ82
OVCA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543012.1
ENSEMBL proteins: ENSP00000263084
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
OVCA2 for ontologies About GeneDecksing
OVCA2 Antibody Products:
Assay Products for OVCA2: |
Protein
Domains /
Families
for OVCA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OVCA2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WZ82ProtoNet protein and cluster: Q8WZ82 1 Blocks protein family: IPB005645 Protein of unknown function DUF341
UniProtKB/Swiss-Prot: OVCA2_HUMAN, Q8WZ82Similarity: Belongs to the UPF0483 (OVCA2) family |
Function
for OVCA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for OVCA2:ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OVCA2 (NM_080822) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OVCA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVCA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVCA2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
OVCA2 for ontologies About GeneDecksing
|
Pathways & Interactions
for OVCA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OVCA2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
OVCA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for OVCA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OVCA2
Search CenterWatch for drugs/clinical trials and news about OVCA2
|
Transcripts
for OVCA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OVCA2 gene: NM_080822.2 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000263084(uc002ftx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OVCA2 (NM_080822) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OVCA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVCA2 |
24/384 AceView cDNA sequences (see all 384): BM551324 BQ575566 BG574155 AL520400 N52176 BI771050 BE349013 BM506717 AK098268 CR620769 CD611372 BM795430 BQ890298 CR590443 BE889801 AI580868 AI401561 BQ712582 BU557900 BM551619 BM713346 CF132220 CR622243 NM_001383
GeneLoc Exon Structure
|
Expression
for OVCA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OVCA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OVCA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OVCA2
UniProtKB/Swiss-Prot: OVCA2_HUMAN, Q8WZ82Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for OVCA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OVCA2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat OVCA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OVCA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OVCA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVCA2 |
Orthologs
for OVCA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for OVCA2 gene from 6/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003339501 |
ovarian cancer-associated gene 2 protein homolog |
48.78(n)
48.62(a) |
|
100333950 XM_002663610.2 XP_002663656.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG54121 , 3 |
CG54121 |
36(a)3
48.44(n)1
38.42(a)1 |
|
92F23
424341 NM_142638.21 NP_650895.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
C25G4.21 , 3 |
dihydrofolate reductase like3
Protein C25G4.21 |
35(a)3
46.25(n)1
38.28(a)1 |
|
IV(12443402-12444354)3
1781941 NM_069975.31 NP_502376.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
FSH3(YOR280C)4
FSH31 |
Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p more4
Fsh3p1 |
39.93(n)1
30.96(a)1 |
|
15(845792-844992)4
8544541, 4 NP_014923.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G654006AT4G243806 |
uncharacterized protein |
23(a)23(a) |
many ↔ manymany ↔ many |
5(26131426-26133259) 4(12612535-12613719) |
rice
(Oryza sativa) |
Liliopsida |
---- |
serine hydrolase domain containing protein, expres...serine hydrolase domain containing protein, expres... |
21(a)19(a) |
many ↔ manymany ↔ many |
4(22243710-22246462) 7(29194079-29196473) |
ENSEMBL Gene Tree for OVCA2 (if available)
TreeFam Gene Tree for OVCA2 (if available) |
Paralogs
for OVCA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OVCA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OVCA2
1 CNV: 7142 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OVCA2 |
|
Disorders
/ Diseases
for OVCA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OVCA2 for disorders About GeneDecksing
OMIM gene information: 607896
OMIM disorders: --
8  diseases for OVCA2: About MalaCardslung squamous cell carcinoma intrahepatic cholangiocarcinoma squamous cell carcinoma cholangiocarcinoma
medulloblastoma ovarian cancer leukemia carcinoma
Export disorders for OVCA2 gene to outside databases
|
Publications
for OVCA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OVCA2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OVCA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PubMed id 11979432)1, 2, 3, 9 Prowse A.H.... Godwin A.K. (2002)
- Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PubMed id 8616839)1, 2, 3 Schultz D.C....Godwin A.K. (1996)
- Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PubMed id 16368187)1, 3 Azizi A.A....Lubec G. (2006)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OVCA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OVCA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OVCA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OVCA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OVCA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OVCA2 gene:
Search GeneIP for patents involving OVCA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OVCA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OVCA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OVCA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OVCA2 | | | OriGene Protein Over-expression Lysate for OVCA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OVCA2 | | OriGene 3'-UTR Clone for OVCA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OVCA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OVCA2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OVCA2 | | OriGene Custom Protein Services for OVCA2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OVCA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OVCA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVCA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OVCA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OVCA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OVCA2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OVCA2 |
| |  |  |  |  | | | | | | Recombinant Protein for OVCA2 |
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 | | | OVCA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVCA2 |
|  |  |  | | | | ThermoFisher Antibodies for OVCA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVCA2 |
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