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OTX2 Gene

protein-coding GIFtS: 62

GC14M056337

orthodenticle homeobox 2
(Previous name: orthodenticle homolog 2 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MCOPS5 ^², ⁵
MGC45000 ^²
OTTHUMP00000064776 ^²

Descriptions
Orthodenticle homolog 2 ^², ³
homeobox protein OTX2 ^²
orthodenticle homeobox 2 ^²
orthodenticle homolog 2 (Drosophila) ^¹

External Ids
HGNC: 8522¹
Entrez Gene: 5015²
UniProtKB: P32243³
Ensembl: ENSG00000165588⁷

Search outside databases for aliases for OTX2 gene

Previous GC identifers: GC14M054592 GC14M051063 GC14M055257

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OTX2:

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription

factors. The encoded protein acts as a transcription factor and may play a role in brain and

sensory organ development. A similar protein in mice is required for proper forebrain development.

Two transcript variants encoding distinct isoforms have been identified for this gene. Other

alternative splice variants may exist, but their full length sequences have not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243

Function: Probably plays a role in the development of the brain and the sense organs. Can bind to

the BCD target sequence (BTS): 5'-TCTAATCCC-3'

Gene Wiki entry for OTX2 (Orthodenticle_homeobox_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OTX2 gene

Entrez Gene cytogenetic band: 14q21-q22 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q22.3

OTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M056337: (about GC identifiers)

Start:	56,337,178 bp from pter
End:	56,346,940 bp from pter
Size:	9,763 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243 (See protein sequence)

Recommended Name: Homeobox protein OTX2

Size: 289 amino acids; 31636 Da

Subcellular location: Nucleus (Probable)

Developmental stage: Embryo

Secondary accessions: Q6GTV3 Q9HAW3 Q9P2R1

Alternative splicing: 2 isoforms: P32243-1 P32243-2

REFSEQ proteins (2 alternative transcripts):

NP_068374.1 NP_758840.1

ENSEMBL proteins:

ENSP00000386185 ENSP00000343819

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Otx2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0030426	growth cone	IDA	16267555

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Antibodies for OTX2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of OTX2
	Sigma-Aldrich Antibodies for OTX2
	R&D Systems Antibodies for OTX2
	Antibodies from Abcam (Otx2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OTX2

Assays for OTX2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P32243

ProtoNet protein and cluster: P32243

2 Blocks protein families:

IPB003022 Otx2 transcription factor signature

IPB003025 Otx transcription factor signature

UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243

Similarity: Belongs to the paired homeobox family. Bicoid subfamily

Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OTX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OTX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021728

Applied Biosystems Silencer® siRNAs for OTX2

Sigma-Aldrich siRNA for OTX2

Sigma-Aldrich shRNA for OTX2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OTX2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021728
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021728
untagged cDNA clones in CMV expression vector (see all 2): NM_021728

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021728

UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243

Function: Probably plays a role in the development of the brain and the sense organs. Can bind to

the BCD target sequence (BTS): 5'-TCTAATCCC-3'

Genatlas biochemistry entry for OTX2:

Drosophila orthodenticle (otd) homolog,paired-like homeo domain encoding gene 2,expressed in the

developing brain of the anterior neural plate,in mouse embryo,playing a major role in

gastrulation,essential for the early specification of neuroectoderm destined to become fore

midbrain

15/20 MGI mutant phenotypes (inferred from 26 alleles) (MGI details for Otx2) (see all 20 ):

	behavior/neurological	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	nervous system	normal	pigmentation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	--
GO:0008190	eukaryotic initiation factor 4E binding	TAS	15705863
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for OTX2

5/35 Interacting proteins for OTX2 (ENSP00000343819³ P32243²) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²	MINT-2861485
FGF8	ENSP00000321797³	STRING (score=.99)
FOXA2	ENSP00000366319³	STRING (score=.985)
PAX2	ENSP00000359317³	STRING (score=.953)
SOX2	ENSP00000323588³	STRING (score=.934)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007411	axon guidance	IDA	16267555
GO:0008589	regulation of smoothened signaling pathway	TAS	15705863
GO:0030900	forebrain development	TAS	15705863

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OTX2
1 Novoseek chemical compound relationship for OTX2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	7.17	2	12559959 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OTX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OTX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021728

Sigma-Aldrich siRNA for OTX2

Sigma-Aldrich shRNA for OTX2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021728 NM_172337

REFSEQ mRNAs for OTX2 gene (2 alternative transcripts):

NM_021728.2 NM_172337.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021728 NM_172337

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021728
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021728
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021728

Additional cDNA sequence:

AF093138.1 AK314271.1 BC032579.1

6 DOTS entries:

DT.307876 DT.40263755 DT.100025424 DT.100755237 DT.100755238 DT.97842872

24/59 AceView cDNA sequences (see all 59 ):

BU162097 H08255 BE781530 BQ424035 BE778281 BM564760 BM904035 NM_172337

BU154244 BQ639181 BM676861 AA364594 BC032579 BU187294 BU176852 BE779765

BM799551 BM724395 BM903863 BM698799 BU741661 CA397809 BQ432088 AA334301

highest scoring ESTs for OTX2:

BC032579 BE779002 H08155 AA317337 AA334301 AA364594 AA365227 AF093138 AW953935 BE252764

Unigene Cluster for OTX2:

Orthodenticle homeobox 2

Hs.288655 [show with all ESTs]

Unigene Representative Sequence: BC032579

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OTX2 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	·	5e
SP1:							-		-				-		-
SP2:							-		-				-		-				-
SP3:							-		-				-		-				-		-		-
SP4:													-		-				-
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for OTX2

2 Ensembl transcripts including schematic representations:

ENST00000408990 ENST00000339475

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OTX2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OTX2

¹ / ² / ³

5 probe-sets matching OTX2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53326_at²^{, 3}	U95-B	1	0.81	1.00	1.00	1.00	H08155	0.80	1.00	0.91	1
242128_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE779765	0.60	1.00	0.82	1
231731_at²^{, 3}	U133-B	1	0.91	1.00	--	--	NM_021728	0.60	1.00	0.82	1
242128_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231731_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks OTX2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCAACTGGT

SOURCE GeneReport for Unigene cluster: Hs.288655
UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243
Tissue specificity: Expressed in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OTX2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OTX2¹	--	orthodenticle homeobox 2	96.52(n) 99.33(a)	490708 XM_846802.1 XP_851895.1
chimpanzee (Pan troglodytes)	OTX2¹	--	orthodenticle homeobox 2	100(n) 100(a)	452927 XM_001163000.1 XP_001163000.1
cow (Bos taurus)	OTX2¹	--	orthodenticle homeobox 2	96.73(n) 98.99(a)	538953 XM_871744.2 XP_876837.2
rat (Rattus norvegicus)	Otx2¹	--	orthodenticle homolog 2 (Drosophila)	94.35(n) 100(a)	305858 XM_001057814.1 XP_001057814.1
mouse (Mus musculus)	Otx2^{1, 5}	14 (19.00 cM)⁵	orthodenticle homolog 2 (Drosophila)^{1, 5}	94.81(n)¹ 99.31(a)¹	18424¹ NM_144841.2¹ NP_659090.1¹ AK053741⁵ AK081535⁵ (see all 14)

About this table Species with no ortholog for OTX2

ENSEMBL Gene Tree for OTX2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OTX2 gene

GSC² GSC2² OTX1² CRX²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/52 NCBI SNPs in OTX2 are shown (see all 52 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs198238^1,2	A,C,F,H,O	56337151(-)	`ACACCA/GCTATT`	2	--	ng5¹		10	EA NA EU WA	618
	rs171978^1,2	C,F,H,O	56338196(-)	`CTGTAG/AAACCT`	2	--	ut3¹ ese³		12	MN EU EA WA NA	1166
	rs198240^1,2	A,C,F,O	56336681(-)	`TGATTT/CCTGAA`	2	--	ng5¹		7	NA EA	472
	rs198239^1,2	A,C,H	56336776(-)	`ATTTGG/ATTAAG`	2	--	ng5¹		1	EU	120
	rs10047846^1,2	F,H	56337088(+)	`CTCTCT/CGTCCT`	2	--	ng5¹		4	EU EA WA	420
	rs12887365^1,2	H	56336938(+)	`GGAAAA/CCAAGA`	2	--	ng5¹		4	EU EA WA	418
	rs12887341^1,2	H	56336851(+)	`TCCCTC/TTTAAA`	2	--	ng5¹		4	EU EA WA	420
	rs3742576^1,2	H	56338165(+)	`CCCAGT/CATATT`	2	--	ut3¹ ese³		5	EA EU WA	1910
	rs12888466^1,2	H	56336808(+)	`TCTTGT/GCATTC`	2	--	ng5¹		4	EU EA WA	416
	rs34537598^1,2	F	56338641(+)	`GCACTG/ACTGCT`	2	S/S	syn¹		1	NA	64

About this table

HapMap Linkage Disequilibrium images for OTX2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600037 disorders: 610125

UniProtKB/Swiss-Prot: OTX2_HUMAN, P32243

Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125].

Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of

a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia

occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients

manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional

features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of

the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia,

and seizures

4 Novoseek disease relationships for OTX2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anophthalmia	83.59	2	18039390 (1), 18385377 (1)
microphthalmia	75.74	4	17406642 (2), 18039390 (1), 18385377 (1)
medulloblastoma	62.69	19	16462208 (6), 15705891 (4), 17522332 (2), 11015565 (1)
tumors	0.00	1	15705891 (1)

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GeneTests: OTX2

Anophthalmia/Microphthalmia

Human Gene Mutation Database: OTX2
Human Genome Epidemiology Navigator: OTX2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/56 PubMed articles for OTX2 gene (see all 56 ):

Chromosome locations of human EMX and OTX genes. (PubMed id 7959790)^{1, 2, 3} Kastury K....Boncinelli E. (1994)
Heterozygous mutations of OTX2 cause severe ocular malformations. (PubMed id 15846561)^{3, 4} Ragge N.K.... Hanson I.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Elements regulating the transcription of human interstitial retinoid- binding protein (IRBP) gene in cultured retinoblastoma cells. (PubMed id 10372988)^{3, 4} Fong S.L. and Fong W.B. (1999)
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. (PubMed id 8101484)^{3, 4} Simeone A.... Boncinelli E. (1993)
OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. (PubMed id 12559959)^{1, 3} Takeda K....Shibahara S. (2003)
A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. (PubMed id 18728160)^{1, 3} Diaczok D....Radovick S. (2008)
Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. (PubMed id 15705891)^{1, 3} Di C....Yan H. (2005)
BEST1 expression in the retinal pigment epithelium is modulated by OTX family members. (PubMed id 18849347)^{1, 3} Esumi N....Zack D.J. (2009)
Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder. (PubMed id 17541950)^{1, 3} Sabunciyan S....Weis S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5015	HGNC: 8522	AceView: OTX2	Ensembl:ENSG00000165588	euGenes: HUgn5015
ECgene: OTX2	H-InvDB: OTX2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=OTX2

Licensable Technologies for OTX2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OTX2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OTX2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OTX2		Antibodies for OTX2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OTX2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OTX2

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OTX2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for OTX2

Summaries
for OTX2

Genomic Location
for OTX2

Proteins
for OTX2

Protein Domains/
Families
for OTX2

Gene Function
for OTX2

Pathways & Interactions
for OTX2

Drugs & Compounds
for OTX2

Transcripts
for OTX2

Expression
for OTX2

Orthologs
for OTX2

Paralogs
for OTX2

SNPs/Variants
for OTX2

Disorders & Mutations
for OTX2

Medical News
for OTX2

Publications
for OTX2

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Genome Databases showing OTX2

Other Databases showing OTX2

Specialized Databases showing OTX2

Licensable Technologies
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Services
for OTX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OTX2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor OTX2

Summariesfor OTX2

Genomic Locationfor OTX2

Proteinsfor OTX2

Protein Domains/Familiesfor OTX2

Gene Functionfor OTX2

Pathways & Interactionsfor OTX2

Drugs & Compoundsfor OTX2

Transcriptsfor OTX2

Expression for OTX2

Orthologsfor OTX2

Paralogsfor OTX2

SNPs/Variantsfor OTX2

Disorders & Mutationsfor OTX2

Medical Newsfor OTX2

Publicationsfor OTX2

Search for OTX2

Genome Databases showing OTX2

Other Databases showing OTX2

Specialized Databases showing OTX2

Licensable Technologiesfor OTX2

Servicesfor OTX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OTX2

Summaries
for OTX2

Genomic Location
for OTX2

Proteins
for OTX2

Protein Domains/
Families
for OTX2

Gene Function
for OTX2

Pathways & Interactions
for OTX2

Drugs & Compounds
for OTX2

Transcripts
for OTX2

Expression
for OTX2

Orthologs
for OTX2

Paralogs
for OTX2

SNPs/Variants
for OTX2

Disorders & Mutations
for OTX2

Medical News
for OTX2

Publications
for OTX2

Licensable Technologies
for OTX2

Services
for OTX2