Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OTX1 Gene

protein-coding   GIFtS: 52
GCID: GC02P063277

Orthodenticle Homeobox 1

(Previous names: orthodenticle (Drosophila) homolog 1, orthodenticle homolog...)
  See OTX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Orthodenticle Homeobox 11 2
Orthodenticle Homolog 12 3
Orthodenticle (Drosophila) Homolog 11
Orthodenticle Homolog 1 (Drosophila)1
Homeobox Protein OTX12

External Ids:    HGNC: 85211   Entrez Gene: 50132   Ensembl: ENSG000001155077   OMIM: 6000365   UniProtKB: P322423   

Export aliases for OTX1 gene to outside databases

Previous GC identifers: GC02P063406 GC02P063234 GC02P063252 GC02P063189 GC02P063131 GC02P063016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for OTX1 Gene:
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded
protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar
protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternate
splicing results in two transcript variants that encoded the same protein.(provided by RefSeq, Dec 2010)

GeneCards Summary for OTX1 Gene:
OTX1 (orthodenticle homeobox 1) is a protein-coding gene. Diseases associated with OTX1 include non-hodgkin lymphoma, and autism spectrum disorder. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSC.

UniProtKB/Swiss-Prot: OTX1_HUMAN, P32242
Function: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target
sequence (BTS): 5'-TCTAATCCC-3'

Gene Wiki entry for OTX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the OTX1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   AREB6   SRY   POU2F1   E2F   E2F-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTX1 promoter sequence
   Search Chromatin IP Primers for OTX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

OTX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTX1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P063277:  view genomic region     (about GC identifiers)

Start:
63,277,192 bp from pter      End:
63,284,971 bp from pter
Size:
7,780 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OTX1_HUMAN, P32242 (See protein sequence)
Recommended Name: Homeobox protein OTX1  
Size: 354 amino acids; 37327 Da
Developmental stage: Embryo
Secondary accessions: A6NHA2 B3KTJ4 Q53TG6

Explore the universe of human proteins at neXtProt for OTX1: NX_P32242

Explore proteomics data for OTX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OTX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186699.1  NP_055377.1  

    ENSEMBL proteins: 
     ENSP00000355631   ENSP00000282549   ENSP00000385782  

    OTX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OTX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OTX1
    GenScript Custom Purified and Recombinant Proteins Services for OTX1
    Novus Biologicals OTX1 Proteins
    Novus Biologicals OTX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OTX1

     
    Search eBioscience for Proteins for OTX1 

     
    antibodies-online proteins for OTX1 (6 products) 

     
    antibodies-online peptides for OTX1

    OTX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OTX1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OTX1
    Novus Biologicals OTX1 Antibodies
    Search for Antibodies for OTX1 at Abcam
    Cloud-Clone Corp. Antibodies for OTX1
    Search ThermoFisher Antibodies for OTX1
    antibodies-online antibodies for OTX1 (45 products) 

    OTX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OTX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OTX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OTX1
    Cloud-Clone Corp. CLIAs for OTX1
    Search eBioscience for ELISAs for OTX1 
    antibodies-online kits for OTX1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    Selected InterPro protein domains (see all 6):
     IPR003026 Otx1_TF
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR003025 Otx_TF

    Graphical View of Domain Structure for InterPro Entry P32242

    ProtoNet protein and cluster: P32242

    2 Blocks protein domains:
    IPB003025 Otx transcription factor signature
    IPB003026 Otx1 transcription factor signature


    UniProtKB/Swiss-Prot: OTX1_HUMAN, P32242
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with OTX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTX1_HUMAN, P32242
    Function: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target
    sequence (BTS): 5'-TCTAATCCC-3'

         Genatlas biochemistry entry for OTX1:
    Drosophila orthodenticle (otd) homolog,paired-like homeo domain encoding gene 1,expressed in the developing brain
    of mouse embryo,required for corticogenesis and sense organ development

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with OTX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OTX1:
     Synthetic lethal with c-Myc af 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Otx1):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system  reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with OTX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Otx1tm1Sia for OTX1

       genOway: Develop your customized and physiologically relevant rodent model for OTX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OTX1:
    hsa-mir-375 (MIRT020057)

    Block miRNA regulation of human, mouse, rat OTX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTX1 (see all 51):
    hsa-miR-1224-3p hsa-miR-15a hsa-miR-1260b hsa-miR-4305 hsa-let-7a-2* hsa-miR-424 hsa-miR-518c hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidOTX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OTX1
    Predesigned siRNA for gene silencing in human, mouse, rat OTX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OTX1

    Clone
    Products:
         
    OriGene clones in human, mouse for OTX1 (see all 7)
    OriGene ORF clones in mouse, rat for OTX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OTX1 (NM_014562)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OTX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OTX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OTX1_HUMAN, P32242: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with OTX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for OTX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    Development Role of Activin A in cell differentiation and proliferation0.32
    2Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for OTX1
        Transcriptional Regulatory Network in Embryonic Stem Cell

    1 GeneGo (Thomson Reuters) Pathway for OTX1
        Development Role of Activin A in cell differentiation and proliferation


        Pathway & Disease-focused RT2 Profiler PCR Array including OTX1: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OTX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for OTX1 (P322422, 3 ENSP000002825494) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930622, 3, ENSP000003401764MINT-68227 I2D: score=5 STRING: ENSP00000340176
    CHIC2Q9UKJ52, 3, ENSP000002639214MINT-68185 I2D: score=5 STRING: ENSP00000263921
    MDFIQ997502, 3, ENSP000002303214MINT-67015 I2D: score=5 STRING: ENSP00000230321
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66082 I2D: score=5 STRING: ENSP00000377582
    TLE4Q047273, ENSP000003657354I2D: score=1 STRING: ENSP00000365735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007275multicellular organismal development ----
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0022037metencephalon development IEA--

    Find genes that share ontologies with OTX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OTX1 gene (2 alternative transcripts): 
    NM_001199770.1  NM_014562.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366671(uc021vim.1) ENST00000484066 ENST00000282549(uc002scd.3 uc010ypt.2)
    ENST00000477348 ENST00000405984 ENST00000476383
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OTX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTX1 (see all 51):
    hsa-miR-1224-3p hsa-miR-15a hsa-miR-1260b hsa-miR-4305 hsa-let-7a-2* hsa-miR-424 hsa-miR-518c hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidOTX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OTX1
    Predesigned siRNA for gene silencing in human, mouse, rat OTX1
    Clone
    Products:
         
    OriGene clones in human, mouse for OTX1 (see all 7)
    OriGene ORF clones in mouse, rat for OTX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OTX1 (NM_014562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OTX1
    OriGene qSTAR qPCR primer pairs in human, mouse for OTX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTX1
      QuantiTect SYBR Green Assays in human, mouse, rat OTX1
      QuantiFast Probe-based Assays in human, mouse, rat OTX1

    Selected AceView cDNA sequences (see all 28):

    NM_014562 BU689444 BC007621 CD723882 C00754 BQ082107 AK095680 BU632082 
    BM679406 BE258323 AI971638 BF063678 AW136237 AI813505 BU733446 BM713976 
    BE502322 BP357029 BI861916 BE315325 BM720707 BX115302 BE621300 CB243593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OTX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGTTCCAG
    OTX1 Expression
    About this image


    OTX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             Neural progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    OTX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTX1 Protein Expression

    UniProtKB/Swiss-Prot: OTX1_HUMAN, P32242
    Tissue specificity: Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein
    level)

        Pathway & Disease-focused RT2 Profiler PCR Array including OTX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OTX1
    OriGene qSTAR qPCR primer pairs in human, mouse for OTX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTX1
    QuantiTect SYBR Green Assays in human, mouse, rat OTX1
    QuantiFast Probe-based Assays in human, mouse, rat OTX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for OTX1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otx11 , 5 orthodenticle homolog 1 (Drosophila)5
    orthodenticle homolog 11
    88.79(n)1
    97.46(a)1
      11 (14.10 cM)5
    184231  NM_011023.31  NP_035153.11 
     219947645 
    chicken
    (Gallus gallus)
    Aves OTX16
    orthodenticle homeobox 1
    68(a)
    1 ↔ 1
    3(9259795-9261238)
    lizard
    (Anolis carolinensis)
    Reptilia OTX16
    orthodenticle homeobox 1
    71(a)
    1 ↔ 1
    1(120890310-120905192)
    African clawed frog
    (Xenopus laevis)
    Amphibia otx1-A2 transcription factor Otx1, orthodenticle homolog 1 79.12(n)    AY029294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045290.12   -- 79.58(n)   30500  BC045290.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta oc6
    ocelliless
    25(a)
    1 → many
    X(8524192-8544714)


    ENSEMBL Gene Tree for OTX1 (if available)
    TreeFam Gene Tree for OTX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OTX1 gene
    GSC2  PITX12  OTX22  UNCX2  VSX12  HESX12  PITX22  VSX22  
    PROP12  PITX32  DMBX12  GSC22  CRX2  MIXL12  
    9 SIMAP similar genes for OTX1 using alignment to 4 protein entries:     OTX1_HUMAN (see all proteins):
    NKX2-5    OTX2    RAX2    PRRX1    CRX    DUX2
    POU6F1    SHOX2    HOXB1

    Find genes that share paralogs with OTX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OTX1 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582352671,2
    C--63277843(+) ACCCCC/GGGCTC 2 -- int1 us2k13Minor allele frequency- G:0.48NA WA 240
    rs1807282031,2
    --63277865(+) GCCCGA/GCTCCC 2 -- int1 us2k10--------
    rs1872091011,2
    --63278128(+) AACGCA/CGAGCC 2 -- int10--------
    rs1920962941,2
    --63278169(+) CCTTGC/TGGCCC 2 -- int10--------
    rs1820867451,2
    --63278180(+) CTCGGC/GGCGAT 2 -- int10--------
    rs778206501,2
    C--63278303(+) TGGGAA/GGAAGG 2 -- int11Minor allele frequency- G:0.01WA 118
    rs558553711,2
    C--63278534(+) TCCCGA/GCTTCC 2 -- int10--------
    rs116920161,2
    C,F,A,H--63278594(+) TTGGTG/AAGCCG 2 -- int11Minor allele frequency- A:0.03NA 92
    rs116919381,2
    C,H--63278649(+) TCCTCC/AGAAGT 2 -- int15Minor allele frequency- A:0.00NS EA NA 418
    rs102032361,2
    C,H--63278687(+) AAAGTC/ATTTGA 2 -- int14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for OTX1 (63277192 - 63284971 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OTX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874233CNV Loss21882294
    nsv7313OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTX1
    DNA2.0 Custom Variant and Variant Library Synthesis for OTX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600036    OMIM disorders: --

    2 diseases for OTX1:    
    About MalaCards
    non-hodgkin lymphoma    autism spectrum disorder


    Find genes that share disorders with OTX1           About GenesLikeMe

    Genetic Association Database (GAD): OTX1
    Human Genome Epidemiology (HuGE) Navigator: OTX1 (1 document)

    Export disorders for OTX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OTX1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with OTX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina. (PubMed id 19414065)1, 2 Larsen K.B....ller M. (Int. J. Dev. Neurosci. 2009)
    2. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Easton D.F. (Nat. Genet. 2009)
    3. Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders. (PubMed id 19018235)1, 4 Laroche F....Robel L. (Psychiatr. Genet. 2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Chromosome locations of human EMX and OTX genes. (PubMed id 7959790)1, 3 Kastury K....Boncinelli E. (Genomics 1994)
    8. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. (PubMed id 8101484)1, 2 Simeone A.... Boncinelli E. (EMBO J. 1993)
    9. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PubMed id 11901358)1, 9 Francks C....Monaco A.P. (Psychiatr. Genet. 2002)
    10. Epilepsy and brain abnormalities in mice lacking the Otx1 gene. (PubMed id 8841200)1, 9 Acampora D....Simeone A. (Nat. Genet. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5013 HGNC: 8521 AceView: OTX1 Ensembl:ENSG00000115507 euGenes: HUgn5013
    ECgene: OTX1 H-InvDB: OTX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OTX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OTX1 gene:
    Search GeneIP for patents involving OTX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of OTX1
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OTX1  
     OriGene qPCR primer pairs and template standards for OTX1   OriGene Protein Over-expression Lysate for OTX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OTX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OTX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OTX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OTX1   OriGene Custom Protein Services for OTX1  

     
     
     Block miRNA regulation of human, mouse, rat OTX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OTX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTX1 Predesigned siRNA for gene silencing in human, mouse, rat OTX1
     QuantiFast Probe-based Assays in human, mouse, rat OTX1 QuantiTect SYBR Green Assays in human, mouse, rat OTX1
     PCR Arrays including human, mouse, rat OTX1 Search Chromatin IP Primers for OTX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTX1  Search GeneGlobe Interaction Network for OTX1
     Regulatory tfbs in OTX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OTX1 GenScript cDNA clones with any tag delivered in your preferred vector for OTX1
     GenScript Custom Assay Services for OTX1 GenScript Custom overexpressing Cell Line Services for OTX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OTX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OTX1 antibodies
     OTX1 proteins
     OTX1 lysates
     Search for Antibodies for OTX1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for OTX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OTX1
     Antibodies for OTX1
     ELISAs for OTX1
     CLIAs for OTX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for OTX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTX1
     SwitchGear 3'UTR luciferase reporter plasmids for OTX1
     SwitchGear Promoter luciferase reporter plasmids for OTX1
     Search ThermoFisher Antibodies for OTX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTX1
     Browse compounds at ApexBio
     Search Addgene for plasmids for OTX1
      Search eBioscience for proteins for OTX1
      Search eBioscience for elisas for OTX1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OTX1
     antibodies-online antibodies for OTX1 (45 products)
     antibodies-online kits for OTX1 (6 products)
     antibodies-online peptides for OTX1
     antibodies-online proteins for OTX1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OTX1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4