Aliases for OTULIN Gene
External Ids for OTULIN Gene
Previous HGNC Symbols for OTULIN Gene
GeneCards Summary for OTULIN Gene
OTULIN (OTU Deubiquitinase With Linear Linkage Specificity) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TNF signaling (REACTOME). GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is FAM105A.
UniProtKB/Swiss-Prot for OTULIN Gene
Deubiquitinase that specifically removes linear (Met-1-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.