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OTULIN Gene

protein-coding   GIFtS: 39
GCID: GC05P014667

OTU Deubiquitinase With Linear Linkage Specificity

(Previous names: family with sequence similarity 105, member B)
(Previous symbol: FAM105B)
  Search for OTULIN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase With Linear Linkage Specificity1 2     OTU Domain-Containing Deubiquitinase With Linear Linkage Specificity2 3
FAM105B1 2 5     GUM2 5
Family With Sequence Similarity 105, Member B1 2     Protein FAM105B2
gumby1 2     Ubiquitin Thioesterase Otulin2
Deubiquitinating Enzyme Otulin2 3     EC 3.4.19.123
Ubiquitin Thioesterase Gumby2 3     

External Ids:    HGNC: 251181   Entrez Gene: 902682   Ensembl: ENSG000001541247   OMIM: 6157125   UniProtKB: Q96BN83   

Export aliases for OTULIN gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OTULIN Gene:
OTULIN (OTU deubiquitinase with linear linkage specificity) is a protein-coding gene. An important paralog of this gene is FAM105A.

UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8
Function: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and
acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct
interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required
during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together
with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC
complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2
in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for OTULIN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTULIN promoter sequence
   Search Chromatin IP Primers for OTULIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTULIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

OTULIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTULIN gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P014667:  view genomic region     (about GC identifiers)

Start:
14,664,773 bp from pter      End:
14,699,842 bp from pter
Size:
35,070 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8 (See protein sequence)
Recommended Name: Ubiquitin thioesterase otulin  
Size: 352 amino acids; 40263 Da
Subunit: Interacts with RNF31; the interaction is direct
Sequence caution: Sequence=AAH07706.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15392.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03828.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
6 PDB 3D structures from and Proteopedia for OTULIN:
3ZNV (3D)        3ZNX (3D)        3ZNZ (3D)        4KSJ (3D)        4KSK (3D)        4KSL (3D)    
Secondary accessions: D3DTD3 Q8NAS0 Q96IA3

Explore the universe of human proteins at neXtProt for OTULIN: NX_Q96BN8

Explore proteomics data for OTULIN at MOPED

Post-translational modifications: 

  • Ubiquitinated1
  • Acetylated1
  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OTULIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612357.4  
    ENSEMBL proteins: 
     ENSP00000427016   ENSP00000284274   ENSP00000421928   ENSP00000424966  

    OTULIN Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for OTULIN 

    OTULIN Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for OTULIN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    2 InterPro protein domains:
     IPR023235 FAM105
     IPR023237 FAM105B

    Graphical View of Domain Structure for InterPro Entry Q96BN8

    ProtoNet protein and cluster: Q96BN8

    UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8
    Domain: The specificity for linear polyubiquitin is given by the 'Glu-16' residue in ubiquitin chain
    (PubMed:23746843)
    Similarity: Belongs to the peptidase C65 family. Otulin subfamily
    Similarity: Contains 1 OTU domain


    Find genes that share domains with OTULIN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUL_HUMAN, Q96BN8
    Function: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and
    acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct
    interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required
    during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together
    with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC
    complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2
    in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Biophysicochemical properties: Kinetic parameters: KM=7.98 uM for linear diubiquitin; Note=Kcat is 6.3 sec(-1)
    with linear diubiquitin as substrate;

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity IMP--
         
    Find genes that share ontologies with OTULIN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OTULIN:
     Synthetic lethal with c-Myc af 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fam105b):
     cardiovascular system  cellular  craniofacial  embryogenesis  hematopoietic system 
     mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with OTULIN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTULIN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTULIN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTULIN

    miRNA
    Products:
        
    miRTarBase miRNAs that target OTULIN:
    hsa-mir-96-5p (MIRT048714), hsa-mir-29c-3p (MIRT020410), hsa-mir-32-5p (MIRT028260), hsa-mir-155-5p (MIRT020632), hsa-mir-16-5p (MIRT051214), hsa-let-7a-5p (MIRT052362)

    Block miRNA regulation of human, mouse, rat OTULIN using miScript Target Protectors
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTULIN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OTUL_HUMAN, Q96BN8: Cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0071797LUBAC complex IEA--

    Find genes that share ontologies with OTULIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTULIN
    Interactions:

        Search GeneGlobe Interaction Network for OTULIN

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for OTULIN (Q96BN82, 3 ENSP000002842744) via UniProtKB, MINT, STRING, and/or I2D (see all 586)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146413, ENSP000000053404I2D: score=4 STRING: ENSP00000005340
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002040sprouting angiogenesis ISS--
    GO:0006508proteolysis ----
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP--
    GO:0045087innate immune response IMP--
    GO:0050728negative regulation of inflammatory response IMP--

    Find genes that share ontologies with OTULIN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTULIN (OTUL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OTULIN gene: 
    NM_138348.4  

    Unigene Cluster for OTULIN:

    Family with sequence similarity 105, member B
    Hs.406335  [show with all ESTs]
    Unigene Representative Sequence: NM_138348
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503023 ENST00000507335 ENST00000284274(uc003jfk.3) ENST00000514913
    ENST00000506417 ENST00000508678
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat OTULIN
      QuantiFast Probe-based Assays in human, mouse, rat OTULIN

    Additional mRNA sequence: 

    AK092203.1 AK095615.1 AK123480.1 BC007706.2 BC015392.1 

    6 DOTS entries:

    DT.456027  DT.422750  DT.120864481  DT.100018838  DT.40282289  DT.91697295 

    Selected AceView cDNA sequences (see all 151):

    AA465594 BQ922658 BC007706 AI703372 BF437971 AI870147 BC015392 AA927538 
    AA279338 BG010314 CA417491 BF445185 BG058615 AK123480 BQ187227 AA987588 
    NM_138348 BX484800 BQ186639 AI873183 BX095915 AI631071 BQ184661 AA828158 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OTULIN    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:              -                 -                                 
    SP2:        -     -                 -                                 
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for OTULIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTULIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTULIN Expression
    About this image

    OTULIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTULIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406335
        Custom PCR Arrays for OTULIN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTULIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OTULIN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam105b1 , 5 family with sequence similarity 105, member B1, 5 87.69(n)1
    90.06(a)1
      15 (10.31 cM)5
    4329401  NM_001013792.21  NP_001013814.21 
     276059195 
    chicken
    (Gallus gallus)
    Aves FAM105B1 family with sequence similarity 105, member B 66.45(n)
    61.18(a)
      427097  XM_004935104.1  XP_004935161.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM105B6
    family with sequence similarity 105, member B
    59(a)
    1 ↔ 1
    4(60643273-60685163)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ060002.12   -- 75.11(n)    BJ060002.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000016651 fibrous sheath CABYR-binding protein-like 56.39(n)
    47.26(a)
      100001665  XM_001341582.4  XP_001341618.4 


    ENSEMBL Gene Tree for OTULIN (if available)
    TreeFam Gene Tree for OTULIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTULIN gene
    FAM105A2  

    Find genes that share paralogs with OTULIN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTULIN (see all 725)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425312051,2
    --14662906(+) TTCTGA/GGTGGA 1 -- us2k10--------
    rs1891815691,2
    --14662956(+) TCTCAA/CGGTGG 1 -- us2k10--------
    rs1527851,2
    C,F,H--14663047(+) aaacaT/Cagcat 1 -- us2k1 tfbs315Minor allele frequency- C:0.09NS EA NA WA 1732
    rs1152264001,2
    C--14663132(+) CCTGAC/TGGAAT 1 -- us2k10--------
    rs2015402311,2
    C--14663202(+) CACAAA/CCTGTG 1 -- us2k10--------
    rs1391200171,2
    --14663244(+) AGTTTG/TGGGGG 1 -- us2k10--------
    rs1141022481,2
    C,F--14663304(+) CACTTT/CGGAAT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1930655781,2
    --14663311(+) GAATAA/GTCCTT 1 -- us2k10--------
    rs2508781,2
    C,F,A,H--14663362(+) cggcgT/Cttctt 1 -- us2k18Minor allele frequency- C:0.03NS EA NA 540
    rs1416716611,2
    --14663433(+) TGCACA/GTTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OTULIN (14664773 - 14699842 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OTULIN: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTULIN
    DNA2.0 Custom Variant and Variant Library Synthesis for OTULIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615712    OMIM disorders: --


    Find genes that share disorders with OTULIN           About GenesLikeMe


    Export disorders for OTULIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTULIN gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with OTULIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. (PubMed id 23708998)1, 2, 3 Rivkin E.... Cordes S.P. (Nature 2013)
    2. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1- linked polyubiquitin. (PubMed id 23746843)1, 2, 3 Keusekotten K.... Komander D. (Cell 2013)
    3. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. (PubMed id 23806334)1, 2 Fiil B.K....Gyrd-Hansen M. (Mol. Cell 2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)2 Mevissen T.E.... Komander D. (Cell 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90268 HGNC: 25118 AceView: LOC90268 Ensembl:ENSG00000154124 euGenes: HUgn90268
    ECgene: OTULIN H-InvDB: OTULIN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTULIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTULIN gene:
    Search GeneIP for patents involving OTULIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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