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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTUD7B Gene

protein-coding   GIFtS: 45
GCID: GC01M149912

OTU domain containing 7B

(Previous names: zinc finger, A20 domain containing 1 )
(Previous symbol: ZA20D1)
  Search for OTUD7B
in our new
 Human Malady Compendium 
Biological research products
for OTUD7B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
OTU Domain Containing 7B1 2     Zinc Finger A20 Domain-Containing Protein 12 3
ZA20D11 2 3     Zinc Finger Protein Cezanne2 3
CEZANNE1 2 5     Cellular Zinc Finger Anti-NF-KappaB Cezanne2
Zinc Finger, A20 Domain Containing 11 2     OTU Domain-Containing Protein 7B2
Cellular Zinc Finger Anti-NF-Kappa-B Protein2 3     EC 3.4.19.123

External Ids:    HGNC: 166831   Entrez Gene: 569572   Ensembl: ENSG000001631137   OMIM: 6117485   UniProtKB: Q6GQQ93   

Export aliases for OTUD7B gene to outside databases

Previous GC identifers: GC01M148178 GC01M121292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3,
an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to
non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3
proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections.
Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked
polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure
in vivo. Hydrolyzes both linear and branched forms of polyubiquitin

Gene Wiki entry for OTUD7B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTUD7B gene promoter:
         Sox5   AML1a   Pbx1a   FOXF2   SRY   POU2F1   POU2F1a   FOXJ2   LyF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD7B promoter sequence
   Search SABiosciences Chromatin IP Primers for OTUD7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

OTUD7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD7B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149912:  view genomic region     (about GC identifiers)

Start:
149,912,231 bp from pter      End:
149,982,686 bp from pter
Size:
70,456 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9 (See protein sequence)
Recommended Name: OTU domain-containing protein 7B  
Size: 843 amino acids; 92526 Da
Subunit: Interacts with TRAF3 and TRAF6. Interacts with PARK7, leading to inhibit deubiquitinase activity. Interacts
with EGFR, ITCH and NEDD4
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner
Sequence caution: Sequence=CAB97494.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z643 D3DUZ8 Q5SZ60 Q8WWA7 Q9NQ53 Q9UFF4
Alternative splicing: 2 isoforms:  Q6GQQ9-1   Q6GQQ9-2   

Explore the universe of human proteins at neXtProt for OTUD7B: NX_Q6GQQ9

Post-translational modifications:

  • Phosphorylated by EGFR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6GQQ9

  • OTUD7B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064590.2  
    ENSEMBL proteins: 
     ENSP00000358131   ENSP00000408231  

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    Novus Biologicals OTUD7B Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OTUD7B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11463333
    GO:0005737cytoplasm IDA11463333
    GO:0015630microtubule cytoskeleton IDA--


    OTUD7B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OTUD7B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003323 OTU
     IPR002653 Znf_A20
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q6GQQ9

    ProtoNet protein and cluster: Q6GQQ9

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 OTU domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3,
    an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to
    non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3
    proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections.
    Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked
    polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure
    in vivo. Hydrolyzes both linear and branched forms of polyubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Deubiquitinase activity is inhibited following interactin with PARK7
    Induction: By TNF-alpha

    Enzyme Number (IUBMB): EC 3.4.19.121

    miRNA
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    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-519a hsa-miR-371-5p hsa-miR-877* hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOTUD7B 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004221ubiquitin thiolesterase activity ISS--
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ISS--
    GO:0008270zinc ion binding IEA--


    OTUD7B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Otud7btm1(NCOM)Cmhd for OTUD7B
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Otud7b):
     behavior/neurological 

    OTUD7B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OTUD7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for OTUD7B (Q6GQQ91, 3 ENSP000003581314) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC50Q8IVM01, 3, ENSP000003762504EBI-527784,EBI-723996 I2D: score=1 STRING: ENSP00000376250
    PARK7Q994971, 3, ENSP000003402784EBI-527784,EBI-1164361 I2D: score=2 STRING: ENSP00000340278
    ACAD9Q9H8453, ENSP000003126184I2D: score=2 STRING: ENSP00000312618
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=2 STRING: ENSP00000299163
    CASP8Q147903, ENSP000003512734I2D: score=1 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002385mucosal immune response ISS--
    GO:0006508proteolysis IEA--
    GO:0016579protein deubiquitination ----
    GO:0035871protein K11-linked deubiquitination IDA--
    GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cascade IDA11463333


    OTUD7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTUD7B
    Search CenterWatch for drugs/clinical trials and news about OTUD7B / OTU7B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OTUD7B gene: 
    NM_020205.2  

    Unigene Cluster for OTUD7B:

    OTU domain containing 7B
    Hs.98322  [show with all ESTs]
    Unigene Representative Sequence: NM_020205
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369135(uc001etn.3) ENST00000417191 ENST00000479905(uc001eto.3)


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    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD7B (see all 84):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-519a hsa-miR-371-5p hsa-miR-877* hsa-miR-4325
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OTUD7B (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTUD7B
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    Additional cDNA sequence: 

    AJ293573.1 AK022480.1 AK299790.1 AL122102.1 BC015719.1 BC020622.1 BC072681.1 BX641079.1 

    7 DOTS entries:

    DT.97833666  DT.40255844  DT.95362236  DT.100758030  DT.100758028  DT.91951038  DT.40302410 

    24/126 AceView cDNA sequences (see all 126):

    BP357326 AA962760 AI742780 AJ293573 AI522101 AI656809 AI144464 AW026392 
    BM473934 AA912781 AW450442 BG676147 NM_020205 CA430150 CA389652 AW044179 
    BC072681 AK022480 BQ431701 AU122751 AW026389 AI142812 BM981759 BX641079 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                       
    SP2:              -                                                               


    ECgene alternative splicing isoforms for OTUD7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTUD7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See OTUD7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTUD7B

    SOURCE GeneReport for Unigene cluster: Hs.98322

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Tissue specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells
    at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OTUD7B gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OTUD7B1 OTU domain containing 7B 71.43(n)
    77.65(a)
      426041  XM_423720.3  XP_423720.3 
    lizard
    (Anolis carolinensis)
    Reptilia OTUD7B6
    --
    58(a)
    1 ↔ 1
    GL344508.1(4050-36511)
    zebrafish
    (Danio rerio)
    Actinopterygii BC058870.12   -- 78.12(n)    BC058870.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0103451 AGAP010345-PA 49.18(n)
    45.32(a)
      1272694  XM_311596.4  XP_311596.4 
    worm
    (Caenorhabditis elegans)
    Secernentea Y50C1A.16
    Protein Y50C1A.1
    30(a)
    1 → many
    I(398894-412513)


    ENSEMBL Gene Tree for OTUD7B (if available)
    TreeFam Gene Tree for OTUD7B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTUD7B gene
    TNFAIP32  ZRANB12  OTUD7A2  
    2 SIMAP similar genes for OTUD7B using alignment to 2 protein entries:     OTU7B_HUMAN (see all proteins):
    OTUD7A    TNFAIP3

    OTUD7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1027 NCBI SNPs in OTUD7B are shown (see all 1027    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57777041,2
    C,--149911935(+) TTGAGA/-AAAAA 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs57777051,2
    C--149911937(+) AAAAAA/-TGTGA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs57777061,2
    C--149912120(+) AAAAA-/ACTGAG 1 -- ds50010--------
    rs2015050661,2
    --149912144(+) ATAGA-/GGGAAGG 1 -- ds50010--------
    rs98041431,2
    C,F,H,--149912145(+) TAGAGG/AGAAGG 1 -- ds500110Minor allele frequency- A:0.15NS EA NA WA 1212
    rs1416205931,2
    --149912191(+) TAACAA/CCATCT 1 -- ds50010--------
    rs730063331,2
    C,--149912287(+) CTTCTG/AGTTAA 1 -- ut312Minor allele frequency- A:0.10WA 120
    rs1865613931,2
    --149912755(+) CATTAC/TTCCTT 1 -- ut310--------
    rs49263981,2
    C,F,A,H,--149912782(+) ACCAAG/AACCCT 1 -- ut3118Minor allele frequency- A:0.01NS NA WA CSA EA 1302
    rs757777081,2
    C--149912907(+) CCCTCA/CCAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OTUD7B (149912231 - 149982686 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for OTUD7B
         2 CNVs: 3313 2326
         1 Indel: 33209

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OTUD7B for disorders           About MalaCards

    OTUD7B for disorders           About GeneDecksing

    OMIM gene information: 611748    OMIM disorders: --


    Export disorders for OTUD7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTUD7B gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with OTUD7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel A20-like proteins. (PubMed id 11463333)1, 2, 3, 9 Evans P.C....Kilshaw P.J. (2001)
    2. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PubMed id 21888622)1, 2 Garcia-Santisteban I.... Rodriguez J.A. (2011)
    3. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. (PubMed id 22179831)1, 2 Pareja F....Yarden Y. (2011)
    4. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (2010)
    5. Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A....Komander D. (2010)
    6. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. (PubMed id 18178551)1, 2 Enesa K....Evans P.C. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. (PubMed id 14748687)1, 2 Evans P.C.... Smith T.S. (2004)
    9. A novel type of deubiquitinating enzyme. (PubMed id 12682062)1, 2 Evans P.C.... Kilshaw P.J. (2003)
    10. Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. (PubMed id 18474597)1, 9 Enesa K....Evans P.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56957 HGNC: 16683 AceView: ZA20D1 Ensembl:ENSG00000163113 euGenes: HUgn56957
    ECgene: OTUD7B H-InvDB: OTUD7B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTUD7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OTUD7B gene:
    Search GeneIP for patents involving OTUD7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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