Aliases for OTUD7B Gene
External Ids for OTUD7B Gene
Previous Symbols for OTUD7B Gene
GeneCards Summary for OTUD7B Gene
OTUD7B (OTU Deubiquitinase 7B) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity.
UniProtKB/Swiss-Prot for OTUD7B Gene
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates Lys-48-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward Lys-11, Lys-48 or Lys-63-linked polyubiquitin chains. In vitro, has preference for Lys-11-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.