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OTUD7B Gene

protein-coding   GIFtS: 50
GCID: GC01M149912

OTU Deubiquitinase 7B

(Previous names: zinc finger, A20 domain containing 1, OTU domain containing...)
(Previous symbol: ZA20D1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase 7B1 2     Zinc Finger Protein Cezanne2 3
ZA20D11 2 3     CEZANNE2 5
OTU Domain Containing 7B1 2     Cellular Zinc Finger Anti-NF-KappaB Cezanne2
Zinc Finger, A20 Domain Containing 11 2     OTU Domain-Containing Protein 7B2
Cellular Zinc Finger Anti-NF-Kappa-B Protein2 3     EC 3.4.19.123
Zinc Finger A20 Domain-Containing Protein 12 3     

External Ids:    HGNC: 166831   Entrez Gene: 569572   Ensembl: ENSG000001631137   OMIM: 6117485   UniProtKB: Q6GQQ93   

Export aliases for OTUD7B gene to outside databases

Previous GC identifers: GC01M148178 GC01M121292


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OTUD7B Gene:
OTUD7B (OTU deubiquitinase 7B) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is TNFAIP3.

UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of
TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In
response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3,
preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal
immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11',
'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin
chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin

Gene Wiki entry for OTUD7B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUD7B gene promoter:
         Sox5   AML1a   Pbx1a   FOXF2   SRY   POU2F1   POU2F1a   FOXJ2   LyF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD7B promoter sequence
   Search Chromatin IP Primers for OTUD7B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

OTUD7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD7B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149912:  view genomic region     (about GC identifiers)

Start:
149,909,705 bp from pter      End:
149,982,686 bp from pter
Size:
72,982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9 (See protein sequence)
Recommended Name: OTU domain-containing protein 7B  
Size: 843 amino acids; 92526 Da
Subunit: Interacts with TRAF3 and TRAF6. Interacts with PARK7, leading to inhibit deubiquitinase activity.
Interacts with EGFR, ITCH and NEDD4
Sequence caution: Sequence=CAB97494.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z643 D3DUZ8 Q5SZ60 Q8WWA7 Q9NQ53 Q9UFF4
Alternative splicing: 2 isoforms:  Q6GQQ9-1   Q6GQQ9-2   

Explore the universe of human proteins at neXtProt for OTUD7B: NX_Q6GQQ9

Explore proteomics data for OTUD7B at MOPED

Post-translational modifications: 

  • Phosphorylated by EGFR1
  • Ubiquitination2 at Lys263
  • Modification sites at PhosphoSitePlus

  • See OTUD7B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064590.2  
    ENSEMBL proteins: 
     ENSP00000358131   ENSP00000408231  

    OTUD7B Human Recombinant Protein Products:

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    antibodies-online proteins for OTUD7B (4 products) 

     
    antibodies-online peptides for OTUD7B

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    antibodies-online antibodies for OTUD7B (21 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    2 InterPro protein domains:
     IPR003323 OTU
     IPR002653 Znf_A20

    Graphical View of Domain Structure for InterPro Entry Q6GQQ9

    ProtoNet protein and cluster: Q6GQQ9

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 OTU domain


    Find genes that share domains with OTUD7B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTU7B_HUMAN, Q6GQQ9
    Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of
    TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In
    response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3,
    preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal
    immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11',
    'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin
    chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Deubiquitinase activity is inhibited following interactin with PARK7
    Induction: By TNF-alpha

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004221ubiquitin thiolesterase activity ISS--
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI11463333
    GO:0008234cysteine-type peptidase activity ISS--
         
    Find genes that share ontologies with OTUD7B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Otud7b):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging 

    Find genes that share phenotypes with OTUD7B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Otud7btm1(NCOM)Cmhd for OTUD7B

       genOway: Develop your customized and physiologically relevant rodent model for OTUD7B

    miRNA
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    miRTarBase miRNAs that target OTUD7B:
    hsa-mir-16-5p (MIRT051066), hsa-mir-1229-3p (MIRT036370), hsa-mir-339-5p (MIRT042784), hsa-mir-877-5p (MIRT037334)

    Block miRNA regulation of human, mouse, rat OTUD7B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD7B (see all 84):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-519a hsa-miR-371-5p hsa-miR-877* hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOTUD7B 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for OTUD7B 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OTU7B_HUMAN, Q6GQQ9: Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent
    manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11463333
    GO:0005737cytoplasm IDA11463333
    GO:0015630microtubule cytoskeleton ----

    Find genes that share ontologies with OTUD7B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUD7B
    Interactions:

        GeneGlobe Interaction Network for OTUD7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OTUD7B (Q6GQQ91, 3 ENSP000003581314) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC50Q8IVM01, 3, ENSP000003762504EBI-527784,EBI-723996 I2D: score=1 STRING: ENSP00000376250
    PARK7Q994971, 3, ENSP000003402784EBI-527784,EBI-1164361 I2D: score=2 STRING: ENSP00000340278
    ACAD9Q9H8453, ENSP000003126184I2D: score=2 STRING: ENSP00000312618
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=2 STRING: ENSP00000299163
    CASP8Q147903, ENSP000003512734I2D: score=1 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002385mucosal immune response ISS--
    GO:0006508proteolysis ----
    GO:0016579protein deubiquitination ----
    GO:0035871protein K11-linked deubiquitination IDA--
    GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling IDA11463333

    Find genes that share ontologies with OTUD7B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUD7B (OTU7B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OTUD7B gene: 
    NM_020205.3  

    Unigene Cluster for OTUD7B:

    OTU domain containing 7B
    Hs.98322  [show with all ESTs]
    Unigene Representative Sequence: NM_020205
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369135(uc001etn.3) ENST00000417191 ENST00000479905(uc001eto.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate OTUD7B (see all 84):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-519a hsa-miR-371-5p hsa-miR-877* hsa-miR-4325
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    Additional mRNA sequence: 

    AJ293573.1 AK022480.1 AK299790.1 AL122102.1 BC015719.1 BC020622.1 BC072681.1 BX641079.1 

    7 DOTS entries:

    DT.97833666  DT.40255844  DT.95362236  DT.100758030  DT.100758028  DT.91951038  DT.40302410 

    Selected AceView cDNA sequences (see all 126):

    BM668513 BM981759 BX641079 AI142812 AI308834 AI419466 AL122102 AI872462 
    AI910603 BF508480 BE222460 AA025534 AA025533 BQ431701 AU122751 BM981325 
    BM684193 BG054992 AI079984 AK022480 AI522101 BC072681 AI742780 AW044179 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                       
    SP2:              -                                                               


    ECgene alternative splicing isoforms for OTUD7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUD7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTUD7B Expression
    About this image


    OTUD7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    OTUD7B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUD7B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98322

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Tissue specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among
    B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the
    mature cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OTUD7B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud7b1 , 5 OTU domain containing 7B1, 5 89.79(n)1
    91.54(a)1
      3 (41.65 cM)5
    2296031  NM_001025613.11  NP_001020784.11 
     961045275 
    chicken
    (Gallus gallus)
    Aves OTUD7B1 OTU domain containing 7B 70.93(n)
    76.87(a)
      426041  XM_423720.4  XP_423720.4 
    lizard
    (Anolis carolinensis)
    Reptilia OTUD7B6
    OTU domain containing 7B
    59(a)
    1 ↔ 1
    GL344508.1(4050-36511)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia otud7b1 OTU domain containing 7B 68.66(n)
    72.01(a)
      779455  XM_002938473.2  XP_002938519.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC058870.12   -- 78.12(n)    BC058870.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0103451 AgaP_AGAP010345 50.22(n)
    46.42(a)
      1272694  XM_311596.4  XP_311596.4 
    worm
    (Caenorhabditis elegans)
    Secernentea otub-26
    Protein OTUB-2 (otub-2) mRNA, complete cds
    33(a)
    1 → many
    I(398891-412847) WBGene00021733


    ENSEMBL Gene Tree for OTUD7B (if available)
    TreeFam Gene Tree for OTUD7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTUD7B gene
    TNFAIP32  ZRANB12  OTUD7A2  
    2 SIMAP similar genes for OTUD7B using alignment to 2 protein entries:     OTU7B_HUMAN (see all proteins):
    OTUD7A    TNFAIP3

    Find genes that share paralogs with OTUD7B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUD7B (see all 1301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57777041,2
    C--149911936(+) TTGAGA/-AAAAA 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs57777051,2
    C--149911937(+) AAAAAA/-TGTGA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs57777061,2
    C--149912120(+) AAAAA-/ACTGAG 1 -- ds50010--------
    rs2015050661,2
    --149912144(+) ATAGA-/GGGAAGG 1 -- ds50010--------
    rs98041431,2
    C,F,H--149912145(+) TAGAGG/AGAAGG 1 -- ds500110Minor allele frequency- A:0.15NS EA NA WA 1212
    rs1416205931,2
    --149912191(+) TAACAA/CCATCT 1 -- ds50010--------
    rs730063331,2
    C--149912287(+) CTTCTG/AGTTAA 1 -- ut312Minor allele frequency- A:0.10WA 120
    rs1120520911,2
    C--149912538(+) GATGAC/TATCAT 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1865613931,2
    --149912755(+) CATTAC/TTCCTT 1 -- ut310--------
    rs49263981,2
    C,F,A,H--149912782(+) ACCAAG/AACCCT 1 -- ut3118Minor allele frequency- A:0.01NS NA WA CSA EA 1302

    HapMap Linkage Disequilibrium report for OTUD7B (149909705 - 149982686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OTUD7B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678478CNV Deletion23128226
    nsv831537CNV Loss17160897
    nsv428235CNV Gain18775914
    nsv8358CNV Gain18304495
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUD7B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611748    OMIM disorders: --


    Find genes that share disorders with OTUD7B           About GenesLikeMe


    Export disorders for OTUD7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUD7B gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with OTUD7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel A20-like proteins. (PubMed id 11463333)1, 2, 3, 9 Evans P.C....Kilshaw P.J. (Biochem. J. 2001)
    2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)1, 2, 3 Mevissen T.E.... Komander D. (Cell 2013)
    3. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PubMed id 21888622)1, 2 Garcia-Santisteban I.... Rodriguez J.A. (Biochem. J. 2012)
    4. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. (PubMed id 22179831)1, 2 Pareja F.... Yarden Y. (Oncogene 2012)
    5. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (J. Biol. Chem. 2011)
    6. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A.... Komander D. (Nat. Struct. Mol. Biol. 2010)
    7. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. (PubMed id 18178551)1, 2 Enesa K.... Evans P.C. (J. Biol. Chem. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. (PubMed id 14748687)1, 2 Evans P.C.... Smith T.S. (Biochem. J. 2004)
    10. A novel type of deubiquitinating enzyme. (PubMed id 12682062)1, 2 Evans P.C.... Kilshaw P.J. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56957 HGNC: 16683 AceView: ZA20D1 Ensembl:ENSG00000163113 euGenes: HUgn56957
    ECgene: OTUD7B H-InvDB: OTUD7B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUD7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUD7B gene:
    Search GeneIP for patents involving OTUD7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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