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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTUD7B Gene

protein-coding   GIFtS: 47
GCID: GC01M149912

OTU Domain Containing 7B

(Previous names: zinc finger, A20 domain containing 1)
(Previous symbol: ZA20D1)
  Search for OTUD7B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
OTU Domain Containing 7B1 2     Zinc Finger Protein Cezanne2 3
ZA20D11 2 3     CEZANNE2 5
Zinc Finger, A20 Domain Containing 11 2     Cellular Zinc Finger Anti-NF-KappaB Cezanne2
Cellular Zinc Finger Anti-NF-Kappa-B Protein2 3     OTU Domain-Containing Protein 7B2
Zinc Finger A20 Domain-Containing Protein 12 3     EC 3.4.19.123

External Ids:    HGNC: 166831   Entrez Gene: 569572   Ensembl: ENSG000001631137   OMIM: 6117485   UniProtKB: Q6GQQ93   

Export aliases for OTUD7B gene to outside databases

Previous GC identifers: GC01M148178 GC01M121292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OTUD7B Gene: 
OTUD7B (OTU domain containing 7B) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is TNFAIP3.

UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of
TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In
response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3,
preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal
immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11',
'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin
chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin

Gene Wiki entry for OTUD7B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTUD7B gene promoter:
         Sox5   AML1a   Pbx1a   FOXF2   SRY   POU2F1   POU2F1a   FOXJ2   LyF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD7B promoter sequence
   Search SABiosciences Chromatin IP Primers for OTUD7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

OTUD7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD7B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149912:  view genomic region     (about GC identifiers)

Start:
149,912,231 bp from pter      End:
149,982,686 bp from pter
Size:
70,456 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9 (See protein sequence)
Recommended Name: OTU domain-containing protein 7B  
Size: 843 amino acids; 92526 Da
Subunit: Interacts with TRAF3 and TRAF6. Interacts with PARK7, leading to inhibit deubiquitinase activity.
Interacts with EGFR, ITCH and NEDD4
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent
manner
Sequence caution: Sequence=CAB97494.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z643 D3DUZ8 Q5SZ60 Q8WWA7 Q9NQ53 Q9UFF4
Alternative splicing: 2 isoforms:  Q6GQQ9-1   Q6GQQ9-2   

Explore the universe of human proteins at neXtProt for OTUD7B: NX_Q6GQQ9

Explore proteomics data for OTUD7B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by EGFR
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6GQQ9

  • OTUD7B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OTUD7B Protein Expression
    REFSEQ proteins: NP_064590.2  
    ENSEMBL proteins: 
     ENSP00000358131   ENSP00000408231  

    Human Recombinant Protein Products for OTUD7B: 
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    Cloud-Clone Corp. Proteins for OTUD7B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11463333
    GO:0005737cytoplasm IDA11463333
    GO:0015630microtubule cytoskeleton IDA--

    OTUD7B for ontologies           About GeneDecksing



    OTUD7B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OTUD: OTU domain containing

    3 InterPro protein domains:
     IPR003323 OTU
     IPR002653 Znf_A20
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q6GQQ9

    ProtoNet protein and cluster: Q6GQQ9

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 OTU domain


    OTUD7B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTU7B_HUMAN, Q6GQQ9
    Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of
    TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In
    response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3,
    preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal
    immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11',
    'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin
    chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Deubiquitinase activity is inhibited following interactin with PARK7
    Induction: By TNF-alpha

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004221ubiquitin thiolesterase activity ISS--
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI11463333
    GO:0008234cysteine-type peptidase activity ISS--
         
    OTUD7B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Otud7b):
     behavior/neurological  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging 

    OTUD7B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Otud7btm1(NCOM)Cmhd for OTUD7B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OTUD7B 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidOTUD7B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD7B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OTUD7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for OTUD7B (Q6GQQ91, 3 ENSP000003581314) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC50Q8IVM01, 3, ENSP000003762504EBI-527784,EBI-723996 I2D: score=1 STRING: ENSP00000376250
    PARK7Q994971, 3, ENSP000003402784EBI-527784,EBI-1164361 I2D: score=2 STRING: ENSP00000340278
    ACAD9Q9H8453, ENSP000003126184I2D: score=2 STRING: ENSP00000312618
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=2 STRING: ENSP00000299163
    CASP8Q147903, ENSP000003512734I2D: score=1 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002385mucosal immune response ISS--
    GO:0006508proteolysis IEA--
    GO:0016579protein deubiquitination ----
    GO:0035871protein K11-linked deubiquitination IDA--
    GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cascade IDA11463333

    OTUD7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTUD7B (OTU7B)

    Search CenterWatch for drugs/clinical trials and news about OTUD7B / OTU7B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OTUD7B gene: 
    NM_020205.3  

    Unigene Cluster for OTUD7B:

    OTU domain containing 7B
    Hs.98322  [show with all ESTs]
    Unigene Representative Sequence: NM_020205
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369135(uc001etn.3) ENST00000417191 ENST00000479905(uc001eto.3)

    miRNA
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    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD7B (see all 84):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-519a hsa-miR-371-5p hsa-miR-877* hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOTUD7B 3' UTR sequence
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    Additional mRNA sequence: 

    AJ293573.1 AK022480.1 AK299790.1 AL122102.1 BC015719.1 BC020622.1 BC072681.1 BX641079.1 

    7 DOTS entries:

    DT.97833666  DT.40255844  DT.95362236  DT.100758030  DT.100758028  DT.91951038  DT.40302410 

    24/126 AceView cDNA sequences (see all 126):

    AI079984 BC072681 AI522101 AK022480 AI742780 AW044179 CA430150 CA389652 
    AA962760 AW450442 AJ293573 AA912781 BG676147 AW026392 AI656809 NM_020205 
    BM473934 AI144464 BP357326 AW026389 BX641079 AI142812 BM668513 BM981759 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                       
    SP2:              -                                                               


    ECgene alternative splicing isoforms for OTUD7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTUD7B expression in normal human tissues (normalized intensities)      OTUD7B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTUD7B Expression
    About this image


    OTUD7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   

    See OTUD7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTUD7B

    SOURCE GeneReport for Unigene cluster: Hs.98322

    UniProtKB/Swiss-Prot: OTU7B_HUMAN, Q6GQQ9
    Tissue specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among
    B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the
    mature cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD7B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OTUD7B gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud7b1 , 5 OTU domain containing 7B1, 5 89.79(n)1
    91.54(a)1
      3 (41.65 cM)5
    2296031  NM_001025614.11  NP_001020785.11 
     961045275 
    chicken
    (Gallus gallus)
    Aves OTUD7B1 OTU domain containing 7B 71.43(n)
    77.65(a)
      426041  XM_423720.3  XP_423720.3 
    lizard
    (Anolis carolinensis)
    Reptilia OTUD7B6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL344508.1(4050-36511)
    zebrafish
    (Danio rerio)
    Actinopterygii BC058870.12   -- 78.12(n)    BC058870.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0103451 AGAP010345-PA 49.18(n)
    45.32(a)
      1272694  XM_311596.4  XP_311596.4 
    worm
    (Caenorhabditis elegans)
    Secernentea otub-26
    Protein Y50C1A.1
    30(a)
    1 → many
    I(398891-412510)


    ENSEMBL Gene Tree for OTUD7B (if available)
    TreeFam Gene Tree for OTUD7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTUD7B gene
    TNFAIP32  ZRANB12  OTUD7A2  
    2 SIMAP similar genes for OTUD7B using alignment to 2 protein entries:     OTU7B_HUMAN (see all proteins):
    OTUD7A    TNFAIP3

    OTUD7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1301 SNPs in OTUD7B are shown (see all 1301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57777041,2
    C--149911936(+) TTGAGA/-AAAAA 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs57777051,2
    C--149911937(+) AAAAAA/-TGTGA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs57777061,2
    C--149912120(+) AAAAA-/ACTGAG 1 -- ds50010--------
    rs2015050661,2
    --149912144(+) ATAGA-/GGGAAGG 1 -- ds50010--------
    rs98041431,2
    C,F,H--149912145(+) TAGAGG/AGAAGG 1 -- ds500110Minor allele frequency- A:0.15NS EA NA WA 1212
    rs1416205931,2
    --149912191(+) TAACAA/CCATCT 1 -- ds50010--------
    rs730063331,2
    C--149912287(+) CTTCTG/AGTTAA 1 -- ut312Minor allele frequency- A:0.10WA 120
    rs1120520911,2
    C--149912538(+) GATGAC/TATCAT 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1865613931,2
    --149912755(+) CATTAC/TTCCTT 1 -- ut310--------
    rs49263981,2
    C,F,A,H--149912782(+) ACCAAG/AACCCT 1 -- ut3118Minor allele frequency- A:0.01NS NA WA CSA EA 1302

    HapMap Linkage Disequilibrium report for OTUD7B (149912231 - 149982686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OTUD7B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678478CNV Deletion23128226
    nsv831537CNV Loss17160897
    nsv428235CNV Gain18775914
    nsv8358CNV Gain18304495
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OTUD7B for disorders           About MalaCards
    OMIM gene information: 611748    OMIM disorders: --


    OTUD7B for disorders           About GeneDecksing


    Export disorders for OTUD7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTUD7B gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with OTUD7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel A20-like proteins. (PubMed id 11463333)1, 2, 3, 9 Evans P.C....Kilshaw P.J. (2001)
    2. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PubMed id 21888622)1, 2 Garcia-Santisteban I.... Rodriguez J.A. (2011)
    3. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. (PubMed id 22179831)1, 2 Pareja F....Yarden Y. (2011)
    4. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (2010)
    5. Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A....Komander D. (2010)
    6. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. (PubMed id 18178551)1, 2 Enesa K....Evans P.C. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. (PubMed id 14748687)1, 2 Evans P.C.... Smith T.S. (2004)
    9. A novel type of deubiquitinating enzyme. (PubMed id 12682062)1, 2 Evans P.C.... Kilshaw P.J. (2003)
    10. Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. (PubMed id 18474597)1, 9 Enesa K....Evans P.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56957 HGNC: 16683 AceView: ZA20D1 Ensembl:ENSG00000163113 euGenes: HUgn56957
    ECgene: OTUD7B H-InvDB: OTUD7B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTUD7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OTUD7B gene:
    Search GeneIP for patents involving OTUD7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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