Aliases for OTUD7A Gene
External Ids for OTUD7A Gene
Previous HGNC Symbols for OTUD7A Gene
Previous GeneCards Identifiers for OTUD7A Gene
The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]
GeneCards Summary for OTUD7A Gene
OTUD7A (OTU Deubiquitinase 7A) is a Protein Coding gene. Diseases associated with OTUD7A include Chromosome 15Q13.3 Microdeletion Syndrome and Congenital Stationary Night Blindness. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD7B.
UniProtKB/Swiss-Prot for OTUD7A Gene
Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.