Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OTUD7A Gene

Aliases for OTUD7A Gene

  • OTU Deubiquitinase 7A 2 3 5
  • Zinc Finger Protein Cezanne 2 3 4
  • OTU Domain Containing 7A 2 3
  • C15orf16 3 4
  • CEZANNE2 3 4
  • OTUD7 3 4
  • Chromosome 15 Open Reading Frame 16 2
  • OTU Domain-Containing 7A 3
  • OTU Domain Containing 7 2
  • EC 3.4.19.12 4
  • Cezanne 2 3
  • C16ORF15 3

External Ids for OTUD7A Gene

Previous HGNC Symbols for OTUD7A Gene

  • C15orf16
  • OTUD7

Previous GeneCards Identifiers for OTUD7A Gene

  • GC15M029564
  • GC15M031773
  • GC15M008953

Summaries for OTUD7A Gene

Entrez Gene Summary for OTUD7A Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD7A Gene

OTUD7A (OTU Deubiquitinase 7A) is a Protein Coding gene. Diseases associated with OTUD7A include chromosome 15q13.3 microdeletion syndrome and congenital stationary night blindness. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is ZRANB1.

UniProtKB/Swiss-Prot for OTUD7A Gene

  • Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD7A Gene

Genomics for OTUD7A Gene

Regulatory Elements for OTUD7A Gene

Enhancers for OTUD7A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OTUD7A on UCSC Golden Path with GeneCards custom track

Promoters for OTUD7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OTUD7A on UCSC Golden Path with GeneCards custom track

Genomic Location for OTUD7A Gene

Chromosome:
15
Start:
31,475,398 bp from pter
End:
31,870,789 bp from pter
Size:
395,392 bases
Orientation:
Minus strand

Genomic View for OTUD7A Gene

Genes around OTUD7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD7A Gene

Proteins for OTUD7A Gene

  • Protein details for OTUD7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE49-OTU7A_HUMAN
    Recommended name:
    OTU domain-containing protein 7A
    Protein Accession:
    Q8TE49
    Secondary Accessions:
    • Q8IWK5

    Protein attributes for OTUD7A Gene

    Size:
    926 amino acids
    Molecular mass:
    100677 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OTUD7A Gene

    Alternative splice isoforms for OTUD7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD7A Gene

Proteomics data for OTUD7A Gene at MOPED

Post-translational modifications for OTUD7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD7A Gene

Domains & Families for OTUD7A Gene

Gene Families for OTUD7A Gene

Protein Domains for OTUD7A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE49

UniProtKB/Swiss-Prot:

OTU7A_HUMAN :
  • Contains 1 OTU domain.
  • Belongs to the peptidase C64 family.
  • Contains 1 A20-type zinc finger.
Domain:
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C64 family.
Similarity:
  • Contains 1 A20-type zinc finger.
genes like me logo Genes that share domains with OTUD7A: view

Function for OTUD7A Gene

Molecular function for OTUD7A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for OTUD7A Gene

Gene Ontology (GO) - Molecular Function for OTUD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 23827681
genes like me logo Genes that share ontologies with OTUD7A: view
genes like me logo Genes that share phenotypes with OTUD7A: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD7A Gene

Localization for OTUD7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTUD7A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD7A Gene COMPARTMENTS Subcellular localization image for OTUD7A gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for OTUD7A Gene

Pathways & Interactions for OTUD7A Gene

SuperPathways for OTUD7A Gene

No Data Available

Interacting Proteins for OTUD7A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305926%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000337853%0d%0a9606.ENSP00000256474%0d%0a
Selected Interacting proteins: Q8TE49-OTU7A_HUMAN ENSP00000305926 for OTUD7A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for OTUD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0050727 regulation of inflammatory response IBA --
GO:0070536 protein K63-linked deubiquitination IBA --
genes like me logo Genes that share ontologies with OTUD7A: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD7A Gene

Drugs & Compounds for OTUD7A Gene

No Compound Related Data Available

Transcripts for OTUD7A Gene

mRNA/cDNA for OTUD7A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD7A Gene

OTU domain containing 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: -

Relevant External Links for OTUD7A Gene

GeneLoc Exon Structure for
OTUD7A
ECgene alternative splicing isoforms for
OTUD7A

Expression for OTUD7A Gene

mRNA expression in normal human tissues for OTUD7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OTUD7A Gene

This gene is overexpressed in Pancreatic juice (33.9) and Testis (32.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for OTUD7A Gene



SOURCE GeneReport for Unigene cluster for OTUD7A Gene Hs.355236

genes like me logo Genes that share expression patterns with OTUD7A: view

Protein tissue co-expression partners for OTUD7A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD7A Gene

Orthologs for OTUD7A Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUD7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTUD7A 35
  • 89.38 (n)
  • 94.16 (a)
OTUD7A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD7A 35
  • 92.64 (n)
  • 97.33 (a)
OTUD7A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud7a 35
  • 88.37 (n)
  • 94.44 (a)
Otud7a 16
Otud7a 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otud7a 35
  • 87.92 (n)
  • 93.34 (a)
oppossum
(Monodelphis domestica)
Mammalia OTUD7A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTUD7A 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTUD7A 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTUD7A 35
  • 71.77 (n)
  • 81.52 (a)
OTUD7A 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD7A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otud7a 35
  • 69.03 (n)
  • 80.56 (a)
Str.20400 35
zebrafish
(Danio rerio)
Actinopterygii LOC559455 35
  • 71.64 (n)
  • 76.53 (a)
OTUD7A 36
  • 71 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea otub-2 36
  • 32 (a)
OneToMany
Species with no ortholog for OTUD7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OTUD7A Gene

ENSEMBL:
Gene Tree for OTUD7A (if available)
TreeFam:
Gene Tree for OTUD7A (if available)

Paralogs for OTUD7A Gene

Paralogs for OTUD7A Gene

(2) SIMAP similar genes for OTUD7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OTUD7A Gene

genes like me logo Genes that share paralogs with OTUD7A: view

Variants for OTUD7A Gene

Sequence variations from dbSNP and Humsavar for OTUD7A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2925 -- 31,636,059(+) TGCAC(A/G)TATTT intron-variant
rs5005225 -- 31,860,626(-) TATAT(A/T)TATCT intron-variant
rs5008844 -- 31,649,188(-) CTGGC(A/G)TCAAG intron-variant
rs5008846 -- 31,649,209(-) CTGGC(A/G)CAGCA intron-variant
rs5008847 -- 31,649,229(-) TCAAA(C/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD7A Gene

Variant ID Type Subtype PubMed ID
esv34100 CNV Loss 18971310
nsv903840 CNV Loss 21882294
nsv469633 CNV Loss 16826518
nsv903844 CNV Loss 21882294
nsv903845 CNV Gain 21882294
essv12200 CNV CNV 17122850
dgv723e1 CNV Complex 17122850
dgv432n67 CNV Gain 20364138
esv29485 CNV Loss 19812545
nsv817679 CNV Loss 17921354
esv2565352 CNV Deletion 19546169
esv2749528 CNV Deletion 23290073
esv2184065 CNV Deletion 18987734
esv2749529 CNV Deletion 23290073
dgv337e201 CNV Deletion 23290073
esv2749532 CNV Deletion 23290073
esv1513730 CNV Deletion 17803354
esv1355532 CNV Deletion 17803354
esv2749534 CNV Deletion 23290073
dgv11e196 CNV Duplication 17116639
dgv2309n71 CNV Gain 21882294
nsv9235 CNV Gain 18304495
nsv469569 CNV Loss 16826518
dgv109e55 CNV Gain 17911159
esv28045 CNV Gain+Loss 19812545
esv2665812 CNV Deletion 23128226
nsv9237 CNV Gain+Loss 18304495
nsv903847 CNV Gain 21882294
essv3058 CNV CNV 17122850
dgv724e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914

Variation tolerance for OTUD7A Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD7A Gene

HapMap Linkage Disequilibrium report
OTUD7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD7A Gene

Disorders for OTUD7A Gene

MalaCards: The human disease database

(2) MalaCards diseases for OTUD7A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 microdeletion syndrome
  • 15q13.3 microdeletion syndrome
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OTUD7A

Genetic Association Database (GAD)
OTUD7A
Human Genome Epidemiology (HuGE) Navigator
OTUD7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD7A
genes like me logo Genes that share disorders with OTUD7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OTUD7A Gene

Publications for OTUD7A Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4 67
  2. Snail1-dependent transcriptional repression of Cezanne2 in hepatocellular carcinoma. (PMID: 23792447) Xu Z. … Gui Y. (Oncogene 2014) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 23650146) Tang W. … Smith N.L. (Genet. Epidemiol. 2013) 3

Products for OTUD7A Gene

Sources for OTUD7A Gene

Content