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Aliases for OTUD7A Gene

Aliases for OTUD7A Gene

  • OTU Deubiquitinase 7A 2 3
  • CEZANNE2 3 4 6
  • OTUD7 3 4 6
  • Zinc Finger Protein Cezanne 2 3 4
  • OTU Domain Containing 7A 2 3
  • C16ORF15 3 6
  • C15orf16 3 4
  • Chromosome 15 Open Reading Frame 16 2
  • OTU Domain-Containing Protein 7A 3
  • OTU Domain-Containing 7A 3
  • OTU Domain Containing 7 2
  • EC 3.4.19.12 4
  • Cezanne 2 3

External Ids for OTUD7A Gene

Previous HGNC Symbols for OTUD7A Gene

  • C15orf16
  • OTUD7

Previous GeneCards Identifiers for OTUD7A Gene

  • GC15M029564
  • GC15M031773
  • GC15M008953

Summaries for OTUD7A Gene

Entrez Gene Summary for OTUD7A Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD7A Gene

OTUD7A (OTU Deubiquitinase 7A) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity. An important paralog of this gene is ZRANB1.

UniProtKB/Swiss-Prot for OTUD7A Gene

  • Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD7A Gene

Genomics for OTUD7A Gene

Regulatory Elements for OTUD7A Gene

Genomic Location for OTUD7A Gene

Start:
31,475,398 bp from pter
End:
31,870,789 bp from pter
Size:
395,392 bases
Orientation:
Minus strand

Genomic View for OTUD7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUD7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD7A Gene

Proteins for OTUD7A Gene

  • Protein details for OTUD7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE49-OTU7A_HUMAN
    Recommended name:
    OTU domain-containing protein 7A
    Protein Accession:
    Q8TE49
    Secondary Accessions:
    • Q8IWK5

    Protein attributes for OTUD7A Gene

    Size:
    926 amino acids
    Molecular mass:
    100677 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OTUD7A Gene

    Alternative splice isoforms for OTUD7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD7A Gene

Proteomics data for OTUD7A Gene at MOPED

Post-translational modifications for OTUD7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD7A Gene

Domains for OTUD7A Gene

Gene Families for OTUD7A Gene

HGNC:
  • OTUD :OTU domain containing

Protein Domains for OTUD7A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE49

UniProtKB/Swiss-Prot:

OTU7A_HUMAN :
  • Q8TE49
Domain:
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C64 family.
Similarity:
  • Contains 1 A20-type zinc finger.
genes like me logo Genes that share domains with OTUD7A: view

Function for OTUD7A Gene

Molecular function for OTUD7A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for OTUD7A Gene

Gene Ontology (GO) - Molecular Function for OTUD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004843 ubiquitin-specific protease activity IDA 23827681
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with OTUD7A: view

miRNA for OTUD7A Gene

miRTarBase miRNAs that target OTUD7A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OTUD7A Gene

Localization for OTUD7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTUD7A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD7A Gene COMPARTMENTS Subcellular localization image for OTUD7A gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for OTUD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with OTUD7A: view

Pathways for OTUD7A Gene

SuperPathways for OTUD7A Gene

No Data Available

Interacting Proteins for OTUD7A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305926%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000337853%0d%0a9606.ENSP00000256474%0d%0a
Selected Interacting proteins: ENSP00000305926 Q8TE49-OTU7A_HUMAN for OTUD7A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OTUD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0035871 protein K11-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD7A: view

No data available for Pathways by source for OTUD7A Gene

Transcripts for OTUD7A Gene

mRNA/cDNA for OTUD7A Gene

(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD7A Gene

OTU domain containing 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: -

Relevant External Links for OTUD7A Gene

GeneLoc Exon Structure for
OTUD7A
ECgene alternative splicing isoforms for
OTUD7A

Expression for OTUD7A Gene

mRNA expression in normal human tissues for OTUD7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OTUD7A Gene

SOURCE GeneReport for Unigene cluster for OTUD7A Gene Hs.355236

genes like me logo Genes that share expressions with OTUD7A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD7A Gene

Orthologs for OTUD7A Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUD7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD7A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTUD7A 35
  • 89.38 (n)
  • 94.16 (a)
OTUD7A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD7A 35
  • 92.64 (n)
  • 97.33 (a)
OTUD7A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud7a 35
  • 88.37 (n)
  • 94.44 (a)
Otud7a 16
Otud7a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OTUD7A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTUD7A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otud7a 35
  • 87.92 (n)
  • 93.34 (a)
chicken
(Gallus gallus)
Aves OTUD7A 35
  • 71.77 (n)
  • 81.52 (a)
OTUD7A 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD7A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otud7a 35
  • 69.03 (n)
  • 80.56 (a)
Str.20400 35
zebrafish
(Danio rerio)
Actinopterygii LOC559455 35
  • 71.64 (n)
  • 76.53 (a)
OTUD7A 36
  • 71 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea otub-2 36
  • 32 (a)
OneToMany
Species with no ortholog for OTUD7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OTUD7A Gene

ENSEMBL:
Gene Tree for OTUD7A (if available)
TreeFam:
Gene Tree for OTUD7A (if available)

Paralogs for OTUD7A Gene

Paralogs for OTUD7A Gene

Selected SIMAP similar genes for OTUD7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OTUD7A Gene

genes like me logo Genes that share paralogs with OTUD7A: view

Variants for OTUD7A Gene

Sequence variations from dbSNP and Humsavar for OTUD7A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2925 -- 31,636,059(+) TGCAC(A/G)TATTT intron-variant
rs721548 -- 31,564,201(+) AAGAC(A/G)TGAGA intron-variant
rs723623 -- 31,489,497(+) CACCC(C/T)GGCCC intron-variant
rs877548 -- 31,488,492(-) TCTCC(C/T)AGTTC intron-variant
rs878227 -- 31,712,102(+) TCAGT(A/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD7A Gene

Variant ID Type Subtype PubMed ID
esv34100 CNV Loss 18971310
nsv903840 CNV Loss 21882294
nsv469633 CNV Loss 16826518
nsv903844 CNV Loss 21882294
nsv903845 CNV Gain 21882294
essv12200 CNV CNV 17122850
dgv723e1 CNV Complex 17122850
dgv432n67 CNV Gain 20364138
esv29485 CNV Loss 19812545
nsv817679 CNV Loss 17921354
esv2565352 CNV Deletion 19546169
esv2749528 CNV Deletion 23290073
esv2184065 CNV Deletion 18987734
esv2749529 CNV Deletion 23290073
dgv337e201 CNV Deletion 23290073
esv2749532 CNV Deletion 23290073
esv1513730 CNV Deletion 17803354
esv1355532 CNV Deletion 17803354
esv2749534 CNV Deletion 23290073
dgv11e196 CNV Duplication 17116639
dgv2309n71 CNV Gain 21882294
nsv9235 CNV Gain 18304495
nsv469569 CNV Loss 16826518
dgv109e55 CNV Gain 17911159
esv28045 CNV Gain+Loss 19812545
esv2665812 CNV Deletion 23128226
nsv9237 CNV Gain+Loss 18304495
nsv903847 CNV Gain 21882294
essv3058 CNV CNV 17122850
dgv724e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914

Relevant External Links for OTUD7A Gene

HapMap Linkage Disequilibrium report
OTUD7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD7A Gene

Disorders for OTUD7A Gene

(1) University of Copenhagen DISEASES for OTUD7A Gene

Relevant External Links for OTUD7A

Genetic Association Database (GAD)
OTUD7A
Human Genome Epidemiology (HuGE) Navigator
OTUD7A
genes like me logo Genes that share disorders with OTUD7A: view

No data available for UniProtKB/Swiss-Prot for OTUD7A Gene

Publications for OTUD7A Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 20400778) Morrison A.C. … Smith N.L. (Circ Cardiovasc Genet 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 23650146) Tang W. … Smith N.L. (Genet. Epidemiol. 2013) 3

Products for OTUD7A Gene

Sources for OTUD7A Gene

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