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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTUD7A Gene

protein-coding   GIFtS: 49
GCID: GC15M031773

OTU domain containing 7A

(Previous names: chromosome 15 open reading frame 16, OTU domain containing...)
(Previous symbols: C15orf16, OTUD7)
 Explore 3 diseases affiliated with
OTUD7A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OTUD7A    

Aliases
for OTUD7A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
OTU Domain Containing 7A1 2     OTU Domain Containing 71
CEZANNE21 2 3 5     C16ORF152
OTUD71 2 3 5     Cezanne 22
C15orf161 2 3     OTU Domain-Containing Protein 7A2
Zinc Finger Protein Cezanne 22 3     EC 3.4.19.123
Chromosome 15 Open Reading Frame 161     C16orf155

External Ids:    HGNC: 207181   Entrez Gene: 1617252   Ensembl: ENSG000001699187   OMIM: 6120245   UniProtKB: Q8TE493   

Export aliases for OTUD7A gene to outside databases

Previous GC identifers: GC15M029564 GC15M008953


Summaries
for OTUD7A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OTUD7A:
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages,
negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU)
domain.(supplied by OMIM, May 2008)

UniProtKB/Swiss-Prot: OTU7A_HUMAN, Q8TE49
Function: Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.
Hydrolyzes both linear and branched forms of polyubiquitin (By similarity)




Genomic Views
for OTUD7A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTUD7A gene promoter:
         ER-alpha   HOXA3   CUTL1   Meis-1b   C/EBPalpha   Nkx6-1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OTUD7A promoter sequence
   Search SABiosciences Chromatin IP Primers for OTUD7A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.3   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13.1

OTUD7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD7A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M031773:  view genomic region     (about GC identifiers)

Start:
 31,775,329 bp from pter      End:
 32,162,992 bp from pter
Size:
 387,664 bases      Orientation:
 minus strand

Proteins
for OTUD7A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OTU7A_HUMAN, Q8TE49 (See protein sequence)
Recommended Name: OTU domain-containing protein 7A  
Size: 926 amino acids; 100677 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for OTUD7A:
2L2D (3D)    
Secondary accessions: Q8IWK5
Alternative splicing: 2 isoforms:  Q8TE49-1   Q8TE49-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTUD7A: NX_Q8TE49

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TE49

    • OTUD7A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_570971.1  
    ENSEMBL proteins: 
     ENSP00000305926   ENSP00000453622   ENSP00000453883   ENSP00000372358  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OTUD7A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    OTUD7A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OTUD7A

    Protein Domains /
    Families
    for OTUD7A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OTUD7A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003323 OTU
     IPR002653 Znf_A20
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q8TE49

    ProtoNet protein and cluster: Q8TE49

    UniProtKB/Swiss-Prot: OTU7A_HUMAN, Q8TE49
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 OTU domain


    Function
    for OTUD7A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OTU7A_HUMAN, Q8TE49
    Function: Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.
    Hydrolyzes both linear and branched forms of polyubiquitin (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

    Enzyme Number (IUBMB): EC 3.4.19.121

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTUD7A
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD7A:
    hsa-miR-3688-3p hsa-miR-593* hsa-miR-4302 hsa-miR-767-5p hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: OTUD7A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008234cysteine-type peptidase activity IEA--
    GO:0008270zinc ion binding IEA--


    OTUD7A for ontologies           About GeneDecksing



    Pathways & Interactions
    for OTUD7A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTUD7A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for OTUD7A (Q8TE493 ENSP000003059264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    OTUD7A for ontologies           About GeneDecksing



    Drugs & Compounds
    for OTUD7A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTUD7A
    Search CenterWatch for drugs/clinical trials and news about OTUD7A / OTU7A 

    Transcripts
    for OTUD7A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OTUD7A gene: 
    NM_130901.1  

    Unigene Cluster for OTUD7A:

    OTU domain containing 7A
    Hs.355236  [show with all ESTs]
    Unigene Representative Sequence: CR749403
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307050(uc001zfq.3) ENST00000560536(uc001zfs.1) ENST00000558371(uc010baa.1)
    ENST00000560598 ENST00000382902(uc001zfr.3)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD7A:
    hsa-miR-3688-3p hsa-miR-593* hsa-miR-4302 hsa-miR-767-5p hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: OTUD7A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ430383.1 AK126002.1 AK308630.1 BC035668.1 CR749403.1 

    6 DOTS entries:

    DT.97799283  DT.101957631  DT.97830618  DT.97830616  DT.106357  DT.92032272 

    8 AceView cDNA sequences:

    AJ430383 AI271697 NM_130901 BM546622 BQ068356 BC035668 AK126002 BF955468 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7A    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:        -           -                 -                                                         
    SP2:                    -                 -                 -                                       
    SP3:        -                                                                                       


    ECgene alternative splicing isoforms for OTUD7A

    Expression
    for OTUD7A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTUD7A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGGTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OTUD7A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OTUD7A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTUD7A

    SOURCE GeneReport for Unigene cluster: Hs.355236
        SABiosciences Custom PCR Arrays for OTUD7A
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    In Situ
    Assay Products:     
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    Orthologs
    for OTUD7A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OTUD7A gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OTUD7A1 OTU domain containing 7A 72.08(n)
    82.07(a)    		   415380  XM_413766.3  XP_413766.2 
    lizard
    (Anolis carolinensis)    		 Reptilia OTUD7A6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 GL343428.1(199656-225683)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.204002 Transcribed sequence with moderate similarity to protein more 76.37(n)    AL862526.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5594551 OTU domain-containing protein 7A-like 72.72(n)
    78.55(a)    		   559455  XM_003201466.1  XP_003201514.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 36(a)
    		 1 → many
    		 Group2.5(1014051-1016162)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y50C1A.16
    		 Protein Y50C1A.1
    		 31(a)
    		 1 → many
    		 I(398894-412513)


    ENSEMBL Gene Tree for OTUD7A (if available)
    TreeFam Gene Tree for OTUD7A (if available) 

    Paralogs
    for OTUD7A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTUD7A gene
    TNFAIP32  OTUD7B2  ZRANB12  
    2 SIMAP similar genes for OTUD7A using alignment to 3 protein entries:     OTU7A_HUMAN (see all proteins):
    MGC131512    OTUD7B

    OTUD7A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OTUD7A
    PGOHUM00000258946


    Genomic Variants
    for OTUD7A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3103 NCBI SNPs in OTUD7A are shown (see all 3103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1808135321,2
    		--31774898(+) AGGAGA/GTTTTG 1 -- ds50010--------
    rs1845518041,2
    		--31775064(+) AAGCCA/CTGGGT 1 -- ds50010--------
    rs58116461,2
    		C--31775127(+) AGGAGA/-AAAAA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1386273191,2
    		--31775174(+) TAAAAC/GAAAGG 1 -- ds50010--------
    rs1428676761,2
    		--31775183(+) GGGCTA/GCGAAT 1 -- ds50010--------
    rs1137237961,2
    		C,--31775209(+) ACTGAG/AGAACA 1 -- ds50012Minor allele frequency- A:0.04NA WA 120
    rs615143821,2
    		C,--31775225(+) ACTCTT/GGCAAT 1 -- ds50012Minor allele frequency- G:0.06WA 120
    rs1474432011,2
    		--31775226(+) CTCTTC/GCAATG 1 -- ds50010--------
    rs128998831,2
    		C--31775390(+) ACAGAG/TGAGGC 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs129037321,2
    		C--31775500(+) gctcaG/Tggccg 2 P syn1 ese30--------

    HapMap Linkage Disequilibrium report for OTUD7A (31775329 - 32025329 bp, first 250kb of OTUD7A)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for OTUD7A
         12 CNVs: 66764 10474 2187 47851 72226 5325 102071 3956 30698 8794 32017 2188
         3 Indels: 45331 25502 25503
         1 Inversion: 37164

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    Disorders / Diseases
    for OTUD7A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OTUD7A for disorders           About GeneDecksing

    OMIM gene information: 612024    OMIM disorders: --

    3 diseases for OTUD7A:    About MalaCards
    congenital stationary night blindness    night blindness    blindness

    1 disease from the University of Copenhagen DISEASES database for OTUD7A:
    Congenital stationary night blindness
    Human Genome Epidemiology (HuGE) Navigator: OTUD7A (1 document)

    Export disorders for OTUD7A gene to outside databases

    Publications
    for OTUD7A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTUD7A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OTUD7A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. Genomic variation associated with mortality among adu lts of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. (PubMed id 20400778)1 Morrison A.C....Smith N.L. (2010)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    6. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. (PubMed id 18952128)9 Li L....Ye Y. (2009)

    External Searches for OTUD7A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing OTUD7A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161725 HGNC: 20718 AceView: C15orf16 Ensembl:ENSG00000169918 euGenes: HUgn161725
    ECgene: OTUD7A H-InvDB: OTUD7A

    Other Databases showing OTUD7A gene

    (According to HUGE)
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    Specialized Databases showing OTUD7A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTUD7A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for OTUD7A gene:
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