Aliases for OTUD7A Gene
External Ids for OTUD7A Gene
Previous HGNC Symbols for OTUD7A Gene
Previous GeneCards Identifiers for OTUD7A Gene
The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]
GeneCards Summary for OTUD7A Gene
OTUD7A (OTU Deubiquitinase 7A) is a Protein Coding gene. Diseases associated with OTUD7A include Chromosome 15Q13.3 Microdeletion Syndrome and Congenital Stationary Night Blindness. Among its related pathways are Ovarian tumor domain proteases and Metabolism of proteins. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD7B.
UniProtKB/Swiss-Prot for OTUD7A Gene
Has deubiquitinating activity towards Lys-11-linked polyubiquitin chains.