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Aliases for OTUD6B Gene

Aliases for OTUD6B Gene

  • OTU Domain Containing 6B 2 3 5
  • DUBA-5 3 4
  • DUBA5 3 4
  • OTU Domain-Containing Protein 6B 3
  • EC 4
  • CGI-77 3

External Ids for OTUD6B Gene

Previous GeneCards Identifiers for OTUD6B Gene

  • GC08P092152
  • GC08P092153
  • GC08P092082
  • GC08P087293

Summaries for OTUD6B Gene

Entrez Gene Summary for OTUD6B Gene

  • This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]

GeneCards Summary for OTUD6B Gene

OTUD6B (OTU Domain Containing 6B) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is OTUD6A.

Gene Wiki entry for OTUD6B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD6B Gene

Genomics for OTUD6B Gene

Regulatory Elements for OTUD6B Gene

Enhancers for OTUD6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F090983 1 ENCODE 10.8 -85.1 -85114 2.2 HDGF ATF1 PKNOX1 CREB3L1 ZNF2 GLIS2 SP3 REST SMARCA4 PBX2 OTUD6B OTUD6B-AS1 LOC105375634 C8orf88 TMEM64
GH08F090675 0.8 Ensembl ENCODE 9.6 -393.9 -393886 1.0 ZNF217 CTCF FOXP2 RAD21 OTUD6B OTUD6B-AS1 TMEM64 LRRC69 ENSG00000254182 LOC102724670
GH08F090571 0.7 ENCODE 10.6 -499.0 -498969 0.2 CTCF ZNF654 TRIM22 ZNF384 REST TBX21 ZNF2 RAD21 RFX5 GATA3 TMEM64 DECR1 NBN OTUD6B LINC01030 RNA5SP273
GH08F090678 0.7 ENCODE 9.6 -390.9 -390884 1.7 NR2F1 TAL1 ETV1 DPF2 ARID1B ZNF316 GATA3 NCOR1 IKZF1 TRIM24 OTUD6B OTUD6B-AS1 TMEM64 ENSG00000254182 LOC102724670
GH08F091023 0.4 Ensembl 12 -46.9 -46896 0.6 SCRT2 OTUD6B OTUD6B-AS1 LOC105375634 GS1-251I9.3 TMEM55A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUD6B on UCSC Golden Path with GeneCards custom track

Promoters for OTUD6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001396104 -396 3201 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 KLF13 ZNF263 SP3

Genomic Location for OTUD6B Gene

91,070,196 bp from pter
91,087,095 bp from pter
16,900 bases
Plus strand

Genomic View for OTUD6B Gene

Genes around OTUD6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD6B Gene

Proteins for OTUD6B Gene

  • Protein details for OTUD6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 6B
    Protein Accession:
    Secondary Accessions:
    • A8K6I1
    • B4DEY0
    • Q9NTA4
    • Q9Y387

    Protein attributes for OTUD6B Gene

    293 amino acids
    Molecular mass:
    33813 Da
    Quaternary structure:
    No Data Available
    • No deubiquitinase activity has been detected when tested (PubMed:23827681). May require some post-translational modification to be active.

    Alternative splice isoforms for OTUD6B Gene


neXtProt entry for OTUD6B Gene

Post-translational modifications for OTUD6B Gene

  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for OTUD6B Gene

No data available for DME Specific Peptides for OTUD6B Gene

Domains & Families for OTUD6B Gene

Gene Families for OTUD6B Gene

Protein Domains for OTUD6B Gene


Suggested Antigen Peptide Sequences for OTUD6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OTU domain.
  • Contains 1 OTU domain.
genes like me logo Genes that share domains with OTUD6B: view

Function for OTUD6B Gene

Molecular function for OTUD6B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for OTUD6B Gene

Gene Ontology (GO) - Molecular Function for OTUD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD6B: view
genes like me logo Genes that share phenotypes with OTUD6B: view

Animal Models for OTUD6B Gene

MGI Knock Outs for OTUD6B:

Animal Model Products

  • Taconic Biosciences Mouse Models for OTUD6B

miRNA for OTUD6B Gene

miRTarBase miRNAs that target OTUD6B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTUD6B Gene

Localization for OTUD6B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD6B gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD6B Gene

Pathways & Interactions for OTUD6B Gene

SuperPathways for OTUD6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OTUD6B: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD6B Gene

Transcripts for OTUD6B Gene

Unigene Clusters for OTUD6B Gene

OTU domain containing 6B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD6B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -

Relevant External Links for OTUD6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OTUD6B Gene

Protein differential expression in normal tissues from HIPED for OTUD6B Gene

This gene is overexpressed in Breast (26.3) and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OTUD6B Gene

Protein tissue co-expression partners for OTUD6B Gene

NURSA nuclear receptor signaling pathways regulating expression of OTUD6B Gene:


SOURCE GeneReport for Unigene cluster for OTUD6B Gene:

genes like me logo Genes that share expression patterns with OTUD6B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD6B Gene

Orthologs for OTUD6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OTUD6B 34 35
  • 99.28 (n)
(Bos Taurus)
Mammalia OTUD6B 34 35
  • 87.77 (n)
(Canis familiaris)
Mammalia OTUD6B 34 35
  • 87.41 (n)
(Mus musculus)
Mammalia Otud6b 34 16 35
  • 85.45 (n)
(Rattus norvegicus)
Mammalia Otud6b 34
  • 83.8 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
-- 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia OTUD6B 35
  • 79 (a)
(Gallus gallus)
Aves OTUD6B 34 35
  • 75.93 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otud6b 34
  • 67.64 (n)
Str.11832 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15114 34
(Danio rerio)
Actinopterygii otud6b 34 35
  • 64.23 (n)
zgc56305 34
fruit fly
(Drosophila melanogaster)
Insecta CG7857 34 35
  • 52.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006160 34
  • 48.22 (n)
(Caenorhabditis elegans)
Secernentea F21D5.2 34
  • 49.11 (n)
otub-3 35
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OTU2 35 37
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62940 34
  • 46.91 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7595 34
(Oryza sativa)
Liliopsida Os04g0619500 34
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
-- 35
  • 43 (a)
-- 35
  • 38 (a)
Species where no ortholog for OTUD6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OTUD6B Gene

Gene Tree for OTUD6B (if available)
Gene Tree for OTUD6B (if available)

Paralogs for OTUD6B Gene

Paralogs for OTUD6B Gene

(1) SIMAP similar genes for OTUD6B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OTUD6B: view

Variants for OTUD6B Gene

Sequence variations from dbSNP and Humsavar for OTUD6B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088008 -- 91,076,252(+) TTTAC(A/G)TGCTA intron-variant
rs10091010 -- 91,076,281(+) TTTTA(G/T)TAGAA intron-variant
rs10095065 -- 91,077,245(+) ACACA(C/T)ACACA intron-variant
rs10113205 -- 91,071,859(+) AAGAC(C/T)AGGCA intron-variant, upstream-variant-2KB
rs10283000 -- 91,080,235(+) CTCTT(C/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD6B Gene

Variant ID Type Subtype PubMed ID
nsv957656 CNV deletion 24416366
nsv831390 CNV gain 17160897
esv3618013 CNV loss 21293372
esv3543832 CNV deletion 23714750
esv2759629 CNV loss 17122850
esv2669421 CNV deletion 23128226

Variation tolerance for OTUD6B Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD6B Gene

Disorders for OTUD6B Gene

Relevant External Links for OTUD6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OTUD6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD6B Gene

Publications for OTUD6B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for OTUD6B Gene

Sources for OTUD6B Gene

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