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Aliases for OTUD6B Gene

Aliases for OTUD6B Gene

  • OTU Domain Containing 6B 2 3 5
  • DUBA-5 3 4
  • DUBA5 3 4
  • EC 3.4.19.12 4
  • CGI-77 3

External Ids for OTUD6B Gene

Previous GeneCards Identifiers for OTUD6B Gene

  • GC08P092152
  • GC08P092153
  • GC08P092082
  • GC08P087293

Summaries for OTUD6B Gene

Entrez Gene Summary for OTUD6B Gene

  • This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]

GeneCards Summary for OTUD6B Gene

OTUD6B (OTU Domain Containing 6B) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is OTUD6A.

Gene Wiki entry for OTUD6B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD6B Gene

Genomics for OTUD6B Gene

Regulatory Elements for OTUD6B Gene

Promoters for OTUD6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OTUD6B on UCSC Golden Path with GeneCards custom track

Genomic Location for OTUD6B Gene

Chromosome:
8
Start:
91,070,196 bp from pter
End:
91,087,095 bp from pter
Size:
16,900 bases
Orientation:
Plus strand

Genomic View for OTUD6B Gene

Genes around OTUD6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD6B Gene

Proteins for OTUD6B Gene

  • Protein details for OTUD6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M0-OTU6B_HUMAN
    Recommended name:
    OTU domain-containing protein 6B
    Protein Accession:
    Q8N6M0
    Secondary Accessions:
    • A8K6I1
    • B4DEY0
    • Q9NTA4
    • Q9Y387

    Protein attributes for OTUD6B Gene

    Size:
    293 amino acids
    Molecular mass:
    33813 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • No deubiquitinase activity has been detected when tested (PubMed:23827681). May require some post-translational modification to be active.

    Alternative splice isoforms for OTUD6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD6B Gene

Proteomics data for OTUD6B Gene at MOPED

Post-translational modifications for OTUD6B Gene

  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for OTUD6B Gene

Antibody Products

No data available for DME Specific Peptides for OTUD6B Gene

Domains & Families for OTUD6B Gene

Gene Families for OTUD6B Gene

Protein Domains for OTUD6B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6M0

UniProtKB/Swiss-Prot:

OTU6B_HUMAN :
  • Contains 1 OTU domain.
Domain:
  • Contains 1 OTU domain.
genes like me logo Genes that share domains with OTUD6B: view

Function for OTUD6B Gene

Molecular function for OTUD6B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for OTUD6B Gene

Gene Ontology (GO) - Molecular Function for OTUD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with OTUD6B: view
genes like me logo Genes that share phenotypes with OTUD6B: view

Animal Models for OTUD6B Gene

MGI Knock Outs for OTUD6B:

Animal Model Products

  • Taconic Biosciences Mouse Models for OTUD6B

miRNA for OTUD6B Gene

miRTarBase miRNAs that target OTUD6B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTUD6B Gene

Localization for OTUD6B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD6B Gene COMPARTMENTS Subcellular localization image for OTUD6B gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
nucleus 2
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD6B Gene

Pathways & Interactions for OTUD6B Gene

SuperPathways for OTUD6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD6B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OTUD6B Gene

Drugs & Compounds for OTUD6B Gene

No Compound Related Data Available

Transcripts for OTUD6B Gene

Unigene Clusters for OTUD6B Gene

OTU domain containing 6B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD6B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for OTUD6B Gene

GeneLoc Exon Structure for
OTUD6B
ECgene alternative splicing isoforms for
OTUD6B

Expression for OTUD6B Gene

mRNA expression in normal human tissues for OTUD6B Gene

Protein differential expression in normal tissues from HIPED for OTUD6B Gene

This gene is overexpressed in Breast (26.3) and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OTUD6B Gene



SOURCE GeneReport for Unigene cluster for OTUD6B Gene Hs.30532

genes like me logo Genes that share expression patterns with OTUD6B: view

Protein tissue co-expression partners for OTUD6B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD6B Gene

Orthologs for OTUD6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD6B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTUD6B 35
  • 87.77 (n)
  • 87.74 (a)
OTUD6B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD6B 35
  • 87.41 (n)
  • 85.76 (a)
OTUD6B 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud6b 35
  • 85.45 (n)
  • 86.07 (a)
Otud6b 16
Otud6b 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTUD6B 35
  • 99.28 (n)
  • 99.38 (a)
OTUD6B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otud6b 35
  • 83.8 (n)
  • 85.14 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OTUD6B 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTUD6B 35
  • 75.93 (n)
  • 77.98 (a)
OTUD6B 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia otud6b 35
  • 67.64 (n)
  • 69.82 (a)
Str.11832 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15114 35
zebrafish
(Danio rerio)
Actinopterygii otud6b 35
  • 64.23 (n)
  • 64.6 (a)
zgc56305 35
otud6b 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006160 35
  • 48.22 (n)
  • 43.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7857 35
  • 52.16 (n)
  • 43.13 (a)
CG7857 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F21D5.2 35
  • 49.11 (n)
  • 36.64 (a)
otub-3 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OTU2 36
  • 29 (a)
OneToMany
OTU2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62940 35
  • 46.91 (n)
  • 40.74 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7595 35
rice
(Oryza sativa)
Liliopsida Os04g0619500 35
  • 47.91 (n)
  • 42.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
Species with no ortholog for OTUD6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OTUD6B Gene

ENSEMBL:
Gene Tree for OTUD6B (if available)
TreeFam:
Gene Tree for OTUD6B (if available)

Paralogs for OTUD6B Gene

Paralogs for OTUD6B Gene

(1) SIMAP similar genes for OTUD6B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OTUD6B: view

Variants for OTUD6B Gene

Sequence variations from dbSNP and Humsavar for OTUD6B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3210518 - 91,084,834(+) TACAC(A/G/T)GTTGG reference, missense
rs4501548 -- 91,075,665(+) TGCCC(A/G)AGTAA intron-variant
rs4501549 -- 91,075,933(+) AGCAT(A/G)TCTCT intron-variant
rs4501550 -- 91,075,984(+) TACAA(A/G)CTTTT intron-variant
rs6993713 -- 91,074,464(+) GTTCA(C/T)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD6B Gene

Variant ID Type Subtype PubMed ID
essv220 CNV CNV 17122850
nsv831390 CNV Gain 17160897
esv2669421 CNV Deletion 23128226

Variation tolerance for OTUD6B Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD6B Gene

HapMap Linkage Disequilibrium report
OTUD6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD6B Gene

Disorders for OTUD6B Gene

Relevant External Links for OTUD6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD6B

No disorders were found for OTUD6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD6B Gene

Publications for OTUD6B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for OTUD6B Gene

Sources for OTUD6B Gene

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