OTUD6A Gene
protein-coding GIFtS: 37
GCID: GC0XP069282
|
|
OTU domain containing 6A
| |
Aliases
for OTUD6A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| OTU Domain Containing 6A1 2 | | FLJ258311 | | DUBA21 2 3 5 | | HIN-6 Protease2 | | HSHIN61 2 | | OTU Domain-Containing Protein 6A2 | | DUBA-22 3 | | |
Export aliases for OTUD6A gene to outside databasesPrevious GC identifers: GC0XP069066 GC0XP069199 GC0XP063103 |
Summaries
for OTUD6A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OTUD6A:
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages,negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU)domain.(supplied by OMIM, May 2008)
|
Genomic Views
for OTUD6A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OTUD6A gene promoter:
RREB-1 COUP HNF-4alpha2 NF-AT HNF-4alpha1 NF-AT4 NF-AT2 SEF-1 (1) NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OTUD6A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD6A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1OTUD6A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP069282: view genomic region
(about GC identifiers)
Start:
|
69,282,341 bp from pter |
End:
|
69,284,029 bp from pter |
Size:
|
1,689 bases |
Orientation:
|
plus strand |
|
Proteins
for OTUD6A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OTU6A_HUMAN, Q7L8S5 (See
protein sequence)Recommended Name: OTU domain-containing protein 6A Size: 288 amino acids; 33300 Da
Secondary accessions: B2RPB7Explore the universe of human proteins at neXtProt for OTUD6A: NX_Q7L8S5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L8S5
OTUD6A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997203.1
ENSEMBL proteins: ENSP00000339389
Human Recombinant Protein Products:
OTUD6A Antibody Products:
Assay Products for OTUD6A: |
Protein
Domains /
Families
for OTUD6A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OTUD6A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7L8S5ProtoNet protein and cluster: Q7L8S5 UniProtKB/Swiss-Prot: OTU6A_HUMAN, Q7L8S5Similarity: Contains 1 OTU domain |
Function
for OTUD6A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OTUD6A (NM_207320) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTUD6A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD6A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD6A |
|
Pathways & Interactions
for OTUD6A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTUD6A
|
Drugs & Compounds
for OTUD6A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OTUD6A
Search CenterWatch for drugs/clinical trials and news about OTUD6A / OTU6A
|
Transcripts
for OTUD6A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OTUD6A gene: NM_207320.1 Unigene Cluster for OTUD6A: OTU domain containing 6A Hs.447381 Unigene Representative Sequence: NM_2073201 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000338352(uc004dxu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OTUD6A (NM_207320) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTUD6A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD6A |
Additional cDNA sequence: AK098697.1 BC137355.1 BC137356.1 1 DOTS entry: DT.99927667 2 AceView cDNA sequences: NM_207320 AK098697
GeneLoc Exon Structure
|
Expression
for OTUD6A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OTUD6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGACAGCG
About this image
See OTUD6A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.447381
SABiosciences Custom PCR Arrays for OTUD6A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTUD6A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTUD6A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTUD6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTUD6A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD6A |
Orthologs
for OTUD6A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for OTUD6A gene from 5/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
otud6b6 |
OTU domain containing 6B |
44(a) |
1 → many |
19(35201113-35266742) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG78576 |
-- |
33(a) |
1 → many |
3L(15496700-15497994) |
worm
(Caenorhabditis elegans) |
Secernentea |
F21D5.26 |
Protein F21D5.2, isoform a |
23(a) |
1 → many |
IV(8728126-8730506) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G629406 |
cysteine proteinases family protein |
27(a) |
1 → many |
3(23262865-23264731) |
rice
(Oryza sativa) |
Liliopsida |
-- |
OTU-like cysteine protease family protein, putativ... |
32(a) |
1 → many |
4(31289272-31292331) |
ENSEMBL Gene Tree for OTUD6A (if available)
TreeFam Gene Tree for OTUD6A (if available) |
Paralogs
for OTUD6A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OTUD6A gene
- OTUD6B2
1 SIMAP similar gene for OTUD6A using alignment to 1 protein entry: OTU6A_HUMAN:OTUD6B
OTUD6A for paralogs About GeneDecksing
|
Genomic Variants
for OTUD6A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OTUD6A (69282341 - 69284029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OTUD6A: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OTUD6A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OTUD6A for disorders About GeneDecksing
OMIM gene information: 300714
OMIM disorders: --
1  disease for OTUD6A: About MalaCardsmalaria
Export disorders for OTUD6A gene to outside databases
|
Publications
for OTUD6A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OTUD6A gene integrated from 9 sources:
(articles sorted by number of sources associating them with OTUD6A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OTUD6A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OTUD6A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OTUD6A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OTUD6A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OTUD6A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OTUD6A gene:
Search GeneIP for patents involving OTUD6A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OTUD6A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OTUD6A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OTUD6A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTUD6A | | | OriGene Protein Over-expression Lysate for OTUD6A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OTUD6A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD6A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OTUD6A | | OriGene Custom Protein Services for OTUD6A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OTUD6A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTUD6A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD6A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTUD6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTUD6A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTUD6A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OTUD6A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | OTUD6A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD6A |
|  |  |  | | | | Search ThermoFisher Antibodies for OTUD6A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD6A |
|
|
|
|
