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Aliases for OTUD6A Gene

Aliases for OTUD6A Gene

  • OTU Deubiquitinase 6A 2 3
  • DUBA2 3 4 6
  • OTU Domain-Containing Protein 6A 3
  • OTU Domain Containing 6A 2
  • HIN-6 Protease 3
  • EC 4
  • HSHIN6 3
  • DUBA-2 4

External Ids for OTUD6A Gene

Previous GeneCards Identifiers for OTUD6A Gene

  • GC0XP069066
  • GC0XP069199
  • GC0XP069282
  • GC0XP063103

Summaries for OTUD6A Gene

Entrez Gene Summary for OTUD6A Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD6A Gene

OTUD6A (OTU Deubiquitinase 6A) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity. An important paralog of this gene is OTUD6B.

UniProtKB/Swiss-Prot for OTUD6A Gene

  • Deubiquitinating enzyme that hydrolyzes Lys-27-, Lys-29- and Lys-33-linked polyubiquitin chains. Also able to hydrolyze Lys-11-linked ubiquitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD6A Gene

Genomics for OTUD6A Gene

Regulatory Elements for OTUD6A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OTUD6A Gene

70,062,491 bp from pter
70,064,179 bp from pter
1,689 bases
Plus strand

Genomic View for OTUD6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUD6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD6A Gene

Proteins for OTUD6A Gene

  • Protein details for OTUD6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 6A
    Protein Accession:
    Secondary Accessions:
    • B2RPB7

    Protein attributes for OTUD6A Gene

    288 amino acids
    Molecular mass:
    33300 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTUD6A Gene

Proteomics data for OTUD6A Gene at MOPED

Post-translational modifications for OTUD6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD6A Gene

Domains for OTUD6A Gene

Gene Families for OTUD6A Gene

Protein Domains for OTUD6A Gene


Suggested Antigen Peptide Sequences for OTUD6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OTU domain.
  • Contains 1 OTU domain.
genes like me logo Genes that share domains with OTUD6A: view

Function for OTUD6A Gene

Molecular function for OTUD6A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes Lys-27-, Lys-29- and Lys-33-linked polyubiquitin chains. Also able to hydrolyze Lys-11-linked ubiquitin chains.

Enzyme Numbers (IUBMB) for OTUD6A Gene

Gene Ontology (GO) - Molecular Function for OTUD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 23827681
genes like me logo Genes that share ontologies with OTUD6A: view

Animal Model Products

miRNA for OTUD6A Gene

miRTarBase miRNAs that target OTUD6A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD6A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD6A Gene

Localization for OTUD6A Gene

Subcellular locations from

Jensen Localization Image for OTUD6A Gene COMPARTMENTS Subcellular localization image for OTUD6A gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD6A Gene

Pathways for OTUD6A Gene

SuperPathways for OTUD6A Gene

No Data Available

Interacting Proteins for OTUD6A Gene

Gene Ontology (GO) - Biological Process for OTUD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0035523 protein K29-linked deubiquitination IDA 23827681
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:1990167 protein K27-linked deubiquitination IDA 23827681
GO:1990168 protein K33-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD6A: view

No data available for Pathways by source for OTUD6A Gene

Transcripts for OTUD6A Gene

mRNA/cDNA for OTUD6A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD6A Gene

OTU domain containing 6A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD6A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD6A Gene

No ASD Table

Relevant External Links for OTUD6A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD6A Gene

mRNA expression in normal human tissues for OTUD6A Gene

mRNA differential expression in normal tissues according to GTEx for OTUD6A Gene

This gene is overexpressed in Testis (52.5).

Protein differential expression in normal tissues for OTUD6A Gene

This gene is overexpressed in Testis (55.0) and Bone (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OTUD6A Gene

SOURCE GeneReport for Unigene cluster for OTUD6A Gene Hs.447381

genes like me logo Genes that share expressions with OTUD6A: view

Expression partners for OTUD6A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OTUD6A Gene

Orthologs for OTUD6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD6A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OTUD6A 35
  • 78.05 (n)
  • 66.9 (a)
  • 66 (a)
(Canis familiaris)
Mammalia OTUD6A 35
  • 80.73 (n)
  • 71.28 (a)
  • 71 (a)
(Mus musculus)
Mammalia Otud6a 35
  • 71.08 (n)
  • 64.11 (a)
Otud6a 16
Otud6a 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Otud6a 35
  • 70.62 (n)
  • 63.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
(Gallus gallus)
Aves OTUD6B 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
(Danio rerio)
Actinopterygii otud6b 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7857 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea otub-3 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OTU2 36
  • 24 (a)
(Triticum aestivum)
Liliopsida Ta.11946 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
-- 36
  • 44 (a)
-- 36
  • 36 (a)
Species with no ortholog for OTUD6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for OTUD6A Gene

Gene Tree for OTUD6A (if available)
Gene Tree for OTUD6A (if available)

Paralogs for OTUD6A Gene

Paralogs for OTUD6A Gene

(1) SIMAP similar genes for OTUD6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTUD6A: view

Variants for OTUD6A Gene

Sequence variations from dbSNP and Humsavar for OTUD6A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2148825 -- 70,062,314(-) CAAGT(G/T)CTAGG upstream-variant-2KB
rs6525353 -- 70,060,604(+) ggatc(A/G)cttga upstream-variant-2KB
rs6625565 -- 70,061,119(+) caggc(A/G)cacac upstream-variant-2KB
rs6625566 -- 70,061,134(+) acacc(C/T)ggcta upstream-variant-2KB
rs6625567 -- 70,061,140(+) ggcta(A/C)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTUD6A Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv6949 CNV Insertion 18451855

Relevant External Links for OTUD6A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD6A Gene

Disorders for OTUD6A Gene

No disorders were found for OTUD6A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OTUD6A Gene

Publications for OTUD6A Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PMID: 23105109) Hayes S.D. … UrbAc S. (J. Biol. Chem. 2012) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OTUD6A Gene

Sources for OTUD6A Gene

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