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OTUD5 Gene

protein-coding   GIFtS: 53
GCID: GC0XM048779

OTU Deubiquitinase 5

(Previous name: OTU domain containing 5)
  Search for OTUD5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase 51 2     Deubiquinating Enzyme A2
DUBA2 3 5     OTU Domain-Containing Protein 52
OTU Domain Containing 51 2     EC 3.4.19.123
Deubiquitinating Enzyme A2 3     

External Ids:    HGNC: 254021   Entrez Gene: 555932   Ensembl: ENSG000000683087   OMIM: 3007135   UniProtKB: Q96G743   

Export aliases for OTUD5 gene to outside databases

Previous GC identifers: GC0XM048536 GC0XM048665 GC0XM046435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTUD5 Gene:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU
domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I
interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I
interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling
complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants
encoding different isoforms have been described. (provided by RefSeq, Oct 2008)

GeneCards Summary for OTUD5 Gene:
OTUD5 (OTU deubiquitinase 5) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3
deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards
'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUD5 gene promoter:
         PPAR-gamma1   Nkx2-5   PPAR-gamma2   Pax-4a   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD5 promoter sequence
   Search Chromatin IP Primers for OTUD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

OTUD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048779:  view genomic region     (about GC identifiers)

Start:
48,779,301 bp from pter      End:
48,815,648 bp from pter
Size:
36,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74 (See protein sequence)
Recommended Name: OTU domain-containing protein 5  
Size: 571 amino acids; 60626 Da
Subunit: Interacts with TRAF3
Sequence caution: Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for OTUD5:
3PFY (3D)        3TMO (3D)        3TMP (3D)    
Secondary accessions: B4DGG7 G5E9D7 Q4KMN9 Q8N6T5 Q9H650 Q9H9U0 Q9NT65
Alternative splicing: 5 isoforms:  Q96G74-1   Q96G74-2   Q96G74-3   Q96G74-4   Q96G74-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTUD5: NX_Q96G74

Explore proteomics data for OTUD5 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-177 is required for deubiquitinating activity1
  • Ubiquitination2 at Lys205, Lys219, Lys253, Lys343, Lys356, Lys370, Lys429
  • Modification sites at PhosphoSitePlus

  • See OTUD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129629.1  NP_001129630.1  NP_001129631.1  NP_060072.1  

    ENSEMBL proteins: 
     ENSP00000390767   ENSP00000156084   ENSP00000365671   ENSP00000401629   ENSP00000379969  
    Reactome Protein details: Q96G74

    OTUD5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OTUD5

     
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    OTUD5 Antibody Products:

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    Cloud-Clone Corp. ELISAs for OTUD5
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    Search eBioscience for ELISAs for OTUD5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    1 InterPro protein domain:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q96G74

    ProtoNet protein and cluster: Q96G74

    1 Blocks protein domain: IPB003323 OTU-like cysteine protease

    UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
    Similarity: Belongs to the peptidase C85 family
    Similarity: Contains 1 OTU domain


    Find genes that share domains with OTUD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUD5_HUMAN, Q96G74
    Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3
    deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards
    'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Inhibited by N-ethyl-maleimide (NEM)
    Induction: Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
         
    Find genes that share ontologies with OTUD5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for OTUD5:
     Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Otud5):
     embryogenesis 

    Find genes that share phenotypes with OTUD5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUD5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTUD5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTUD5

    miRNA
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    miRTarBase miRNAs that target OTUD5:
    hsa-mir-339-5p (MIRT042795), hsa-mir-505-3p (MIRT041070), hsa-mir-1260b (MIRT052692), hsa-let-7e-5p (MIRT051503), hsa-mir-328-3p (MIRT043793)

    Block miRNA regulation of human, mouse, rat OTUD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD5 (see all 38):
    hsa-miR-323-3p hsa-miR-3655 hsa-miR-1224-3p hsa-miR-654-5p hsa-miR-186 hsa-miR-3116 hsa-miR-30c-2* hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidOTUD5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OTUD5

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    GenScript: all cDNA clones in your preferred vector (see all 4): OTUD5 (NM_001136157)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD5
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    Addgene plasmids for OTUD5 

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    eBioscience FlowRNA Probe Sets ( VA1-10456) for OTUD5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with OTUD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OTUD5 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47
    2Gastric cancer network 2
    Gastric cancer network 2


    Find genes that share SuperPaths with OTUD5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OTUD5
        Gastric cancer network 2

    1 Reactome Pathway for OTUD5
        Negative regulators of RIG-I/MDA5 signaling


    1 Kegg Pathway  (Kegg details for OTUD5):
        RIG-I-like receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUD5
    Interactions:

        Search GeneGlobe Interaction Network for OTUD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for OTUD5 (Q96G742, 3 ENSP000001560844) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARPC3O151452, 3MINT-63093 I2D: score=4 
    ENSG00000224264P266403, ENSP000004011214I2D: score=2 STRING: ENSP00000401121
    ENSG00000226589P266403, ENSP000004033594I2D: score=2 STRING: ENSP00000403359
    ENSG00000096171P266403I2D: score=2 
    ENSG00000231116P266403I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0032496response to lipopolysaccharide IDA--
    GO:0045087innate immune response TAS--
    GO:0070536protein K63-linked deubiquitination IDA--

    Find genes that share ontologies with OTUD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUD5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OTUD5 gene (4 alternative transcripts): 
    NM_001136157.1  NM_001136158.1  NM_001136159.1  NM_017602.3  

    Unigene Cluster for OTUD5:

    OTU domain containing 5
    Hs.496098  [show with all ESTs]
    Unigene Representative Sequence: NM_017602
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455452 ENST00000156084(uc004dlu.3 uc004dlv.3 uc011mmp.2)
    ENST00000376488 ENST00000428668 ENST00000484499 ENST00000481142 ENST00000396743(uc004dlt.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate OTUD5 (see all 38):
    hsa-miR-323-3p hsa-miR-3655 hsa-miR-1224-3p hsa-miR-654-5p hsa-miR-186 hsa-miR-3116 hsa-miR-30c-2* hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidOTUD5 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): OTUD5 (NM_001136157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD5
    Addgene plasmids for OTUD5 
    Primer
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK022612.1 AK026260.1 AK294590.1 AL137509.1 BC009917.2 BC011738.2 BC028225.1 BC098440.1 

    20 DOTS entries:

    DT.115522  DT.95209037  DT.92009691  DT.75179188  DT.121324275  DT.423718  DT.121324300  DT.92441247 
    DT.121324266  DT.92441252  DT.95160217  DT.99986692  DT.121324302  DT.86854749  DT.95138795  DT.95160207 
    DT.100762868  DT.121324272  DT.121324286  DT.95151542 

    Selected AceView cDNA sequences (see all 305):

    NM_017602 BG755958 AI650316 BG741141 AU124888 BM543991 AI302063 BU535580 
    AL137509 BM720303 BM662398 BE906996 BQ681851 BQ003188 BG397470 AK026260 
    BI255063 CA426657 AA768028 BE859080 AA736511 BC009917 BX390952 BQ683985 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
    SP1:                    -                 -                                                     -         
    SP2:                    -                 -                                                               
    SP3:                    -                                                                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for OTUD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTUD5 Expression
    About this image

    OTUD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496098

    UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
    Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood
    leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OTUD5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud55 OTU domain containing 5   --   X (3.54 cM) 7841364 
    chicken
    (Gallus gallus)
    Aves OTUD56
    OTU domain containing 5
    78(a)
    1 ↔ 1
    AADN03014390.1(24-4048)
    lizard
    (Anolis carolinensis)
    Reptilia OTUD56
    OTU domain containing 5
    91(a)
    1 ↔ 1
    GL343326.1(1253225-1290080)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC535202 hypothetical protein MGC53520 77.2(n)    BC046254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sibz30i22.12 sibz30i22.1 77.75(n)   368486  CA470320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60916
    --
    25(a)
    1 ↔ 1
    3L(11598536-11602540)
    worm
    (Caenorhabditis elegans)
    Secernentea otub-46
    Protein OTUB-4 (otub-4) mRNA, complete cds
    36(a)
    1 ↔ 1
    IV(3373394-3378130) WBGene00015249
    corn
    (Zea mays)
    Liliopsida Zm.44442 Zea mays CL15553_1 mRNA sequence 77.86(n)    AY106870.1 


    ENSEMBL Gene Tree for OTUD5 (if available)
    TreeFam Gene Tree for OTUD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUD5 (see all 450)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871407141,2
    --48778915(+) GGCATG/TGTGAA 4 -- ds50010--------
    rs1918701451,2
    --48778923(+) GAAAAA/GGCTGC 4 -- ds50010--------
    rs1844661791,2
    --48779158(+) AAGGAA/CAGAGC 4 -- ds50010--------
    rs1891304491,2
    C--48779181(+) GAGAGA/GCAGGC 4 -- ds50010--------
    rs351286251,2
    C--48779254(-) TTCCT-/GGGGGG 4 -- ds50010--------
    rs1932235841,2
    --48779287(+) CAGCAA/GGCAAA 4 -- ds50010--------
    rs1464648561,2
    --48779328(+) GAAGGA/TGGTTT 4 -- ut310--------
    rs1855605441,2
    C--48779433(+) TGCATA/CCTCTG 4 -- ut310--------
    rs1487651481,2
    --48779708(+) TTTCAC/TTGTCC 4 -- ut310--------
    rs1892837911,2
    --48779721(+) GCCGGC/TCTGAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for OTUD5 (48779301 - 48815648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OTUD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6894CNV Insertion18451855
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUD5
    DNA2.0 Custom Variant and Variant Library Synthesis for OTUD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300713    OMIM disorders: --


    Find genes that share disorders with OTUD5           About GenesLikeMe


    Export disorders for OTUD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUD5 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with OTUD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OTUD5 regulates p53 stability by deubiquitinating p53. (PubMed id 24143256)1, 3 Luo J....Zhou X. (PLoS ONE 2013)
    2. Phosphorylation-dependent activity of the deubiquitinase DUBA. (PubMed id 22245969)1, 2 Huang O.W.... Cochran A.G. (Nat. Struct. Mol. Biol. 2012)
    3. DUBA: a deubiquitinase that regulates type I interferon production. (PubMed id 17991829)1, 2 Kayagaki N....Dixit V.M. (Science 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)2 Mevissen T.E.... Komander D. (Cell 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55593 HGNC: 25402 AceView: DKFZp761A052 Ensembl:ENSG00000068308 euGenes: HUgn55593
    ECgene: OTUD5 Kegg: 55593 H-InvDB: OTUD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUD5 gene:
    Search GeneIP for patents involving OTUD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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