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Aliases for OTUD5 Gene

Aliases for OTUD5 Gene

  • OTU Deubiquitinase 5 2 3 5
  • Deubiquitinating Enzyme A 3 4
  • OTU Domain Containing 5 2 3
  • DUBA 3 4
  • OTU Domain-Containing Protein 5 3
  • Deubiquinating Enzyme A 3
  • EC 3.4.19.12 4

External Ids for OTUD5 Gene

Previous GeneCards Identifiers for OTUD5 Gene

  • GC0XM048536
  • GC0XM048665
  • GC0XM048779
  • GC0XM046435

Summaries for OTUD5 Gene

Entrez Gene Summary for OTUD5 Gene

  • This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

GeneCards Summary for OTUD5 Gene

OTUD5 (OTU Deubiquitinase 5) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is ALG13.

UniProtKB/Swiss-Prot for OTUD5 Gene

  • Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).

Additional gene information for OTUD5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD5 Gene

Genomics for OTUD5 Gene

GeneHancer (GH) Regulatory Elements for OTUD5 Gene

Promoters and enhancers for OTUD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048954 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.1 -144 8.1 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 OTUD5 RNU6-722P GPKOW PIM2 SLC35A2 PCSK1N ENSG00000228343 KCND1 GRIPAP1
GH0XI049037 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.4 -82.5 -82507 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 TFE3 PRAF2 OTUD5 RNU6-722P SLC38A5 PLP2 GC0XM049007
GH0XI048933 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +20.1 20124 9.7 HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 IRF4 ENSG00000279155 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343
GH0XI048916 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.2 +38.9 38859 5.6 HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 PIM2 ENSG00000204620 FTSJ1 ENSG00000270012 RBM3 PQBP1 CCDC22 ZNF182 PLP2 OTUD5
GH0XI048710 Enhancer 1.1 FANTOM5 ENCODE 2.3 +245.1 245091 6 FOXA2 ZNF48 RARA YY1 ATF7 CREM RXRA REST RFX3 ZBTB33 PQBP1 OTUD5 PIM2 GRIPAP1 TBC1D25 GC0XM048725 RNU6-1056P SUV39H1 ENSG00000232828
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OTUD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OTUD5 gene promoter:

Genomic Locations for OTUD5 Gene

Genomic Locations for OTUD5 Gene
chrX:48,922,024-48,958,624
(GRCh38/hg38)
Size:
36,601 bases
Orientation:
Minus strand
chrX:48,779,301-48,815,648
(GRCh37/hg19)

Genomic View for OTUD5 Gene

Genes around OTUD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD5 Gene

Proteins for OTUD5 Gene

  • Protein details for OTUD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G74-OTUD5_HUMAN
    Recommended name:
    OTU domain-containing protein 5
    Protein Accession:
    Q96G74
    Secondary Accessions:
    • B4DGG7
    • G5E9D7
    • Q4KMN9
    • Q8N6T5
    • Q9H650
    • Q9H9U0
    • Q9NT65

    Protein attributes for OTUD5 Gene

    Size:
    571 amino acids
    Molecular mass:
    60626 Da
    Quaternary structure:
    • Interacts with TRAF3.
    SequenceCaution:
    • Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD5 Gene

    Alternative splice isoforms for OTUD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD5 Gene

Post-translational modifications for OTUD5 Gene

  • Phosphorylation at Ser-177 is required for deubiquitinating activity.
  • Ubiquitination at isoforms=2, 3, 5205, isoforms=2, 3, 5219, Lys253, isoforms=2, 3, 4, 5343, isoforms=2, 3, 4, 5356, Lys370, and Lys429

No data available for DME Specific Peptides for OTUD5 Gene

Domains & Families for OTUD5 Gene

Gene Families for OTUD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OTUD5 Gene

Suggested Antigen Peptide Sequences for OTUD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96G74

UniProtKB/Swiss-Prot:

OTUD5_HUMAN :
  • Belongs to the peptidase C85 family.
Family:
  • Belongs to the peptidase C85 family.
genes like me logo Genes that share domains with OTUD5: view

Function for OTUD5 Gene

Molecular function for OTUD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethyl-maleimide (NEM).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages.

Enzyme Numbers (IUBMB) for OTUD5 Gene

Gene Ontology (GO) - Molecular Function for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 22245969
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD5: view
genes like me logo Genes that share phenotypes with OTUD5: view

Animal Model Products

Clone Products

  • Addgene plasmids for OTUD5

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD5 Gene

Localization for OTUD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD5 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD5 Gene

Pathways & Interactions for OTUD5 Gene

genes like me logo Genes that share pathways with OTUD5: view

Pathways by source for OTUD5 Gene

1 Cell Signaling Technology pathway for OTUD5 Gene
2 BioSystems pathways for OTUD5 Gene

Gene Ontology (GO) - Biological Process for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination TAS,IEA --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032496 response to lipopolysaccharide IDA 22245969
GO:0070536 protein K63-linked deubiquitination IDA 22245969
genes like me logo Genes that share ontologies with OTUD5: view

No data available for SIGNOR curated interactions for OTUD5 Gene

Drugs & Compounds for OTUD5 Gene

No Compound Related Data Available

Transcripts for OTUD5 Gene

Unigene Clusters for OTUD5 Gene

OTU domain containing 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for OTUD5

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for OTUD5 Gene

GeneLoc Exon Structure for
OTUD5
ECgene alternative splicing isoforms for
OTUD5

Expression for OTUD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTUD5 Gene

Protein differential expression in normal tissues from HIPED for OTUD5 Gene

This gene is overexpressed in Retina (43.2) and Fetal Liver (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OTUD5 Gene



Protein tissue co-expression partners for OTUD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OTUD5 Gene:

OTUD5

SOURCE GeneReport for Unigene cluster for OTUD5 Gene:

Hs.496098

mRNA Expression by UniProt/SwissProt for OTUD5 Gene:

Q96G74-OTUD5_HUMAN
Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for OTUD5 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with OTUD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD5 Gene

Orthologs for OTUD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD5 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud5 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD5 33 34
  • 93.05 (n)
cow
(Bos Taurus)
Mammalia OTUD5 33 34
  • 92.59 (n)
chicken
(Gallus gallus)
Aves OTUD5 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD5 34
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53520 33
zebrafish
(Danio rerio)
Actinopterygii otud5a 34
  • 73 (a)
OneToMany
otud5b 34
  • 68 (a)
OneToMany
sibz30i22.1 33
fruit fly
(Drosophila melanogaster)
Insecta CG6091 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea otub-4 34
  • 36 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.4444 33
Species where no ortholog for OTUD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OTUD5 Gene

ENSEMBL:
Gene Tree for OTUD5 (if available)
TreeFam:
Gene Tree for OTUD5 (if available)

Paralogs for OTUD5 Gene

Paralogs for OTUD5 Gene

genes like me logo Genes that share paralogs with OTUD5: view

Variants for OTUD5 Gene

Sequence variations from dbSNP and Humsavar for OTUD5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000003761 -- 48,955,532(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000190544 -- 48,931,585(-) C/A/T intron_variant
rs1000201639 -- 48,923,079(-) A/G 3_prime_UTR_variant, intron_variant
rs1000252690 -- 48,923,460(-) C/T intron_variant
rs1000551282 -- 48,950,004(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
esv3344450 CNV insertion 20981092
nsv1119633 CNV deletion 24896259
nsv528292 CNV gain 19592680
nsv6894 CNV insertion 18451855

Variation tolerance for OTUD5 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OTUD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD5 Gene

Disorders for OTUD5 Gene

Additional Disease Information for OTUD5

No disorders were found for OTUD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD5 Gene

Publications for OTUD5 Gene

  1. OTUD5 regulates p53 stability by deubiquitinating p53. (PMID: 24143256) Luo J … Zhou X (PloS one 2013) 2 3 58
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 3 4 58
  3. Phosphorylation-dependent activity of the deubiquitinase DUBA. (PMID: 22245969) Huang OW … Cochran AG (Nature structural & molecular biology 2012) 3 4 58
  4. DUBA: a deubiquitinase that regulates type I interferon production. (PMID: 17991829) Kayagaki N … Dixit VM (Science (New York, N.Y.) 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for OTUD5 Gene

  • Addgene plasmids for OTUD5

Sources for OTUD5 Gene

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