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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTUD5 Gene

protein-coding   GIFtS: 52
GCID: GC0XM048779

OTU Domain Containing 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
OTU Domain Containing 51 2
DUBA2 3 5
Deubiquitinating Enzyme A2 3
Deubiquinating Enzyme A2
OTU Domain-Containing Protein 52
EC 3.4.19.123

External Ids:    HGNC: 254021   Entrez Gene: 555932   Ensembl: ENSG000000683087   OMIM: 3007135   UniProtKB: Q96G743   

Export aliases for OTUD5 gene to outside databases

Previous GC identifers: GC0XM048536 GC0XM048665 GC0XM046435


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OTUD5 Gene:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU
domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I
interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I
interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling
complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants
encoding different isoforms have been described. (provided by RefSeq, Oct 2008)

GeneCards Summary for OTUD5 Gene: 
OTUD5 (OTU domain containing 5) is a protein-coding gene. Diseases associated with OTUD5 include pneumonia, and gastric cancer, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Immune System. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3
deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards
'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTUD5 gene promoter:
         PPAR-gamma1   Nkx2-5   PPAR-gamma2   Pax-4a   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for OTUD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

OTUD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048779:  view genomic region     (about GC identifiers)

Start:
48,779,301 bp from pter      End:
48,815,648 bp from pter
Size:
36,348 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74 (See protein sequence)
Recommended Name: OTU domain-containing protein 5  
Size: 571 amino acids; 60626 Da
Subunit: Interacts with TRAF3
Sequence caution: Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for OTUD5:
3PFY (3D)        3TMO (3D)        3TMP (3D)    
Secondary accessions: B4DGG7 Q4KMN9 Q8N6T5 Q9H650 Q9H9U0 Q9NT65
Alternative splicing: 4 isoforms:  Q96G74-1   Q96G74-2   Q96G74-4   Q96G74-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTUD5: NX_Q96G74

Explore proteomics data for OTUD5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-177 is required for deubiquitinating activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96G74

  • OTUD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OTUD5 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129629.1  NP_001129630.1  NP_001129631.1  NP_060072.1  

    ENSEMBL proteins: 
     ENSP00000390767   ENSP00000156084   ENSP00000365671   ENSP00000401629   ENSP00000379969  
    Reactome Protein details: Q96G74
    Human Recombinant Protein Products for OTUD5: 
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    Novus Biologicals OTUD5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OTUD5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    OTUD5 for ontologies           About GeneDecksing



    OTUD5 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OTUD: OTU domain containing

    1 InterPro protein domain:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q96G74

    ProtoNet protein and cluster: Q96G74

    1 Blocks protein domain: IPB003323 OTU-like cysteine protease

    UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
    Similarity: Belongs to the peptidase C85 family
    Similarity: Contains 1 OTU domain


    OTUD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUD5_HUMAN, Q96G74
    Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3
    deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards
    'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Inhibited by N-ethyl-maleimide (NEM)
    Induction: Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
         
    OTUD5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for OTUD5:
     Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Otud5):
     embryogenesis 

    OTUD5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OTUD5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OTUD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTUD5 
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    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD5 (see all 38):
    hsa-miR-323-3p hsa-miR-3655 hsa-miR-1224-3p hsa-miR-654-5p hsa-miR-186 hsa-miR-3116 hsa-miR-30c-2* hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidOTUD5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OTUD5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Gastric cancer network 2
    Gastric cancer network 2

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OTUD5
        Gastric cancer network 2

    4        Reactome Pathways for OTUD5
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for OTUD5):
        RIG-I-like receptor signaling pathway


    OTUD5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTUD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/24 Interacting proteins for OTUD5 (Q96G742, 3 ENSP000001560844) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARPC3O151452, 3MINT-63093 I2D: score=4 
    ENSG00000226589P266403, ENSP000004033594I2D: score=2 STRING: ENSP00000403359
    ENSG00000096171P266403I2D: score=2 
    VARSP266403I2D: score=2 
    GPX4P369693, ENSP000003461034I2D: score=2 STRING: ENSP00000346103
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0032496response to lipopolysaccharide IDA--
    GO:0045087innate immune response TAS--
    GO:0070536protein K63-linked deubiquitination IDA--

    OTUD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTUD5

    Search CenterWatch for drugs/clinical trials and news about OTUD5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OTUD5 gene (4 alternative transcripts): 
    NM_001136157.1  NM_001136158.1  NM_001136159.1  NM_017602.3  

    Unigene Cluster for OTUD5:

    OTU domain containing 5
    Hs.496098  [show with all ESTs]
    Unigene Representative Sequence: NM_017602
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455452 ENST00000156084(uc004dlu.3 uc004dlv.3 uc011mmp.2)
    ENST00000376488 ENST00000428668 ENST00000484499 ENST00000481142 ENST00000396743(uc004dlt.4)

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD5 (see all 38):
    hsa-miR-323-3p hsa-miR-3655 hsa-miR-1224-3p hsa-miR-654-5p hsa-miR-186 hsa-miR-3116 hsa-miR-30c-2* hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidOTUD5 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD5
    Sirion Biotech Customized lentivirus for stable overexpression of OTUD5 
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    Additional mRNA sequence: 

    AK022612.1 AK026260.1 AK294590.1 AL137509.1 BC009917.2 BC011738.2 BC028225.1 BC098440.1 

    20 DOTS entries:

    DT.115522  DT.95209037  DT.92009691  DT.75179188  DT.121324275  DT.423718  DT.121324300  DT.92441247 
    DT.121324266  DT.92441252  DT.95160217  DT.99986692  DT.121324302  DT.86854749  DT.95138795  DT.95160207 
    DT.100762868  DT.121324272  DT.121324286  DT.95151542 

    24/305 AceView cDNA sequences (see all 305):

    BU681125 AA736511 BE859080 BQ683985 BQ003188 CA426657 BQ681851 BQ009623 
    AW016038 BF892066 AA768028 BI255063 BM806347 BQ680900 BM662398 AL137509 
    BG178829 BC028225 AW474411 BX390952 BM720303 AW339581 NM_017602 BQ643871 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
    SP1:                    -                 -                                                     -         
    SP2:                    -                 -                                                               
    SP3:                    -                                                                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for OTUD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTUD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTUD5 Expression
    About this image


    See OTUD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTUD5

    SOURCE GeneReport for Unigene cluster: Hs.496098

    UniProtKB/Swiss-Prot: OTUD5_HUMAN, Q96G74
    Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood
    leukocytes

        SABiosciences Custom PCR Arrays for OTUD5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OTUD5 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud51 , 5 OTU domain containing 51, 5 90.4(n)1
    98.23(a)1
      X (3.54 cM)5
    546441  NM_138604.21  NP_613070.21 
     78413645 
    chicken
    (Gallus gallus)
    Aves OTUD56
    OTU domain containing 5
    77(a)
    1 ↔ 1
    AADN03014390.1(24-4048)
    lizard
    (Anolis carolinensis)
    Reptilia OTUD56
    OTU domain containing 5
    91(a)
    1 ↔ 1
    GL343326.1(1253225-1290080)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC535202 hypothetical protein MGC53520 77.2(n)    BC046254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sibz30i22.12 sibz30i22.1 77.75(n)   368486  CA470320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60916
    --
    25(a)
    1 ↔ 1
    3L(11598536-11602540)
    worm
    (Caenorhabditis elegans)
    Secernentea otub-46
    Protein B0546.2
    32(a)
    1 ↔ 1
    IV(3373394-3378132)
    corn
    (Zea mays)
    Liliopsida Zm.44442 Zea mays CL15553_1 mRNA sequence 77.86(n)    AY106870.1 


    ENSEMBL Gene Tree for OTUD5 (if available)
    TreeFam Gene Tree for OTUD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/450 SNPs in OTUD5 are shown (see all 450)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871407141,2
    --48778915(+) GGCATG/TGTGAA 4 -- ds50010--------
    rs1918701451,2
    --48778923(+) GAAAAA/GGCTGC 4 -- ds50010--------
    rs1844661791,2
    --48779158(+) AAGGAA/CAGAGC 4 -- ds50010--------
    rs1891304491,2
    C--48779181(+) GAGAGA/GCAGGC 4 -- ds50010--------
    rs351286251,2
    C--48779254(-) TTCCT-/GGGGGG 4 -- ds50010--------
    rs1932235841,2
    --48779287(+) CAGCAA/GGCAAA 4 -- ds50010--------
    rs1464648561,2
    --48779328(+) GAAGGA/TGGTTT 4 -- ut310--------
    rs1855605441,2
    C--48779433(+) TGCATA/CCTCTG 4 -- ut310--------
    rs1487651481,2
    --48779708(+) TTTCAC/TTGTCC 4 -- ut310--------
    rs1892837911,2
    --48779721(+) GCCGGC/TCTGAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for OTUD5 (48779301 - 48815648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OTUD5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6894CNV Insertion18451855
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300713    OMIM disorders: --

    2 diseases for OTUD5:    About MalaCards
    pneumonia    gastric cancer


    OTUD5 for disorders           About GeneDecksing


    Export disorders for OTUD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTUD5 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with OTUD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation-dependent activity of the deubiquitinase DUBA. (PubMed id 22245969)1, 2 Huang O.W.... Cochran A.G. (2012)
    2. DUBA: a deubiquitinase that regulates type I interferon production. (PubMed id 17991829)1, 2 Kayagaki N....Dixit V.M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55593 HGNC: 25402 AceView: DKFZp761A052 Ensembl:ENSG00000068308 euGenes: HUgn55593
    ECgene: OTUD5 Kegg: 55593 H-InvDB: OTUD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTUD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OTUD5 gene:
    Search GeneIP for patents involving OTUD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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