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Aliases for OTUD5 Gene

Aliases for OTUD5 Gene

  • OTU Deubiquitinase 5 2 3 5
  • Deubiquitinating Enzyme A 3 4
  • OTU Domain Containing 5 2 3
  • DUBA 3 4
  • OTU Domain-Containing Protein 5 3
  • Deubiquinating Enzyme A 3
  • EC 3.4.19.12 4

External Ids for OTUD5 Gene

Previous GeneCards Identifiers for OTUD5 Gene

  • GC0XM048536
  • GC0XM048665
  • GC0XM048779
  • GC0XM046435

Summaries for OTUD5 Gene

Entrez Gene Summary for OTUD5 Gene

  • This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

GeneCards Summary for OTUD5 Gene

OTUD5 (OTU Deubiquitinase 5) is a Protein Coding gene. Among its related pathways are Ovarian tumor domain proteases and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is ALG13.

UniProtKB/Swiss-Prot for OTUD5 Gene

  • Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).

Additional gene information for OTUD5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD5 Gene

Genomics for OTUD5 Gene

Regulatory Elements for OTUD5 Gene

Enhancers for OTUD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH048933 2 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +20.1 20124 9.7 HDGF FOXA2 ARNT ZFP64 SIN3A ARID4B DMAP1 YBX1 SLC30A9 ZNF766 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343 FOXP3
GH0XH049037 1.4 ENCODE dbSUPER 12.4 -82.5 -82508 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 PRAF2 OTUD5 RNU6-722P SLC38A5 TFE3 PLP2 GC0XM049007
GH0XH048916 1.7 FANTOM5 ENCODE dbSUPER 7.2 +38.9 38859 5.6 HNRNPUL1 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 FOS SP3 FTSJ1 ENSG00000204620 ENSG00000270012 RBM3 PLP2 PQBP1 PIM2 OTUD5 WAS ENSG00000228343
GH0XH048710 1.2 FANTOM5 ENCODE 2.3 +245.1 245091 6 TBP FOXA2 RARA YY1 ATF7 CREM REST RFX3 ZBTB33 HNF4A PQBP1 OTUD5 PIM2 GRIPAP1 TBC1D25 GC0XM048725 RNU6-1056P SUV39H1
GH0XH048491 1.2 FANTOM5 Ensembl ENCODE 1.6 +465.9 465904 1.7 SMARCE1 ZSCAN4 JUN ELF1 DPF2 FOSL1 CTBP1 JUND SMARCA4 POLR2A SLC38A5 EBP RBM3 WAS PORCN OTUD5 GC0XP048480 LOC101927635
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUD5 on UCSC Golden Path with GeneCards custom track

Promoters for OTUD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246533 724 3001 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS

Genomic Locations for OTUD5 Gene

Genomic Locations for OTUD5 Gene
chrX:48,922,024-48,958,624
(GRCh38/hg38)
Size:
36,601 bases
Orientation:
Minus strand
chrX:48,779,301-48,815,648
(GRCh37/hg19)

Genomic View for OTUD5 Gene

Genes around OTUD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD5 Gene

Proteins for OTUD5 Gene

  • Protein details for OTUD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G74-OTUD5_HUMAN
    Recommended name:
    OTU domain-containing protein 5
    Protein Accession:
    Q96G74
    Secondary Accessions:
    • B4DGG7
    • G5E9D7
    • Q4KMN9
    • Q8N6T5
    • Q9H650
    • Q9H9U0
    • Q9NT65

    Protein attributes for OTUD5 Gene

    Size:
    571 amino acids
    Molecular mass:
    60626 Da
    Quaternary structure:
    • Interacts with TRAF3.
    SequenceCaution:
    • Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD5 Gene

    Alternative splice isoforms for OTUD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD5 Gene

Post-translational modifications for OTUD5 Gene

  • Phosphorylation at Ser-177 is required for deubiquitinating activity.
  • Ubiquitination at Lys205, posLast=219219, posLast=253253, Lys343, Lys356, Lys370, and posLast=429429
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OTUD5 Gene

Domains & Families for OTUD5 Gene

Gene Families for OTUD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OTUD5 Gene

Suggested Antigen Peptide Sequences for OTUD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96G74

UniProtKB/Swiss-Prot:

OTUD5_HUMAN :
  • Belongs to the peptidase C85 family.
Family:
  • Belongs to the peptidase C85 family.
genes like me logo Genes that share domains with OTUD5: view

Function for OTUD5 Gene

Molecular function for OTUD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethyl-maleimide (NEM).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages.

Enzyme Numbers (IUBMB) for OTUD5 Gene

Gene Ontology (GO) - Molecular Function for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 22245969
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD5: view
genes like me logo Genes that share phenotypes with OTUD5: view

Animal Model Products

Clone Products

  • Addgene plasmids for OTUD5

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD5 Gene

Localization for OTUD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD5 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD5 Gene

Pathways & Interactions for OTUD5 Gene

genes like me logo Genes that share pathways with OTUD5: view

Pathways by source for OTUD5 Gene

Gene Ontology (GO) - Biological Process for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination TAS,IEA --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032496 response to lipopolysaccharide IDA 22245969
GO:0070536 protein K63-linked deubiquitination IDA 22245969
genes like me logo Genes that share ontologies with OTUD5: view

No data available for SIGNOR curated interactions for OTUD5 Gene

Drugs & Compounds for OTUD5 Gene

No Compound Related Data Available

Transcripts for OTUD5 Gene

Unigene Clusters for OTUD5 Gene

OTU domain containing 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for OTUD5

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for OTUD5 Gene

GeneLoc Exon Structure for
OTUD5
ECgene alternative splicing isoforms for
OTUD5

Expression for OTUD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTUD5 Gene

Protein differential expression in normal tissues from HIPED for OTUD5 Gene

This gene is overexpressed in Retina (43.2) and Fetal Liver (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OTUD5 Gene



Protein tissue co-expression partners for OTUD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OTUD5 Gene:

OTUD5

SOURCE GeneReport for Unigene cluster for OTUD5 Gene:

Hs.496098

mRNA Expression by UniProt/SwissProt for OTUD5 Gene:

Q96G74-OTUD5_HUMAN
Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for OTUD5 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with OTUD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD5 Gene

Orthologs for OTUD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD5 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud5 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD5 33 34
  • 93.05 (n)
cow
(Bos Taurus)
Mammalia OTUD5 33 34
  • 92.59 (n)
chicken
(Gallus gallus)
Aves OTUD5 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD5 34
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53520 33
zebrafish
(Danio rerio)
Actinopterygii otud5a 34
  • 73 (a)
OneToMany
otud5b 34
  • 68 (a)
OneToMany
sibz30i22.1 33
fruit fly
(Drosophila melanogaster)
Insecta CG6091 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea otub-4 34
  • 36 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.4444 33
Species where no ortholog for OTUD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OTUD5 Gene

ENSEMBL:
Gene Tree for OTUD5 (if available)
TreeFam:
Gene Tree for OTUD5 (if available)

Paralogs for OTUD5 Gene

Paralogs for OTUD5 Gene

genes like me logo Genes that share paralogs with OTUD5: view

Variants for OTUD5 Gene

Sequence variations from dbSNP and Humsavar for OTUD5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000003761 -- 48,955,532(+) TCCTG(C/T)CCCTG intron-variant
rs1000190544 -- 48,931,585(+) ACCAG(C/T)GTGGC intron-variant
rs1000201639 -- 48,923,079(+) AACAG(A/G)AGGAG intron-variant, utr-variant-3-prime
rs1000252690 -- 48,923,460(+) GACCC(C/T)AGACC intron-variant
rs1000551282 -- 48,950,004(+) ATTAG(C/G)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD5 Gene

Variant ID Type Subtype PubMed ID
nsv6894 CNV insertion 18451855
nsv528292 CNV gain 19592680
nsv1119633 CNV deletion 24896259
esv3344450 CNV insertion 20981092
esv32909 CNV gain+loss 17666407

Variation tolerance for OTUD5 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD5 Gene

Disorders for OTUD5 Gene

Relevant External Links for OTUD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD5

No disorders were found for OTUD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD5 Gene

Publications for OTUD5 Gene

  1. OTUD5 regulates p53 stability by deubiquitinating p53. (PMID: 24143256) Luo J … Zhou X (PloS one 2013) 2 3 60
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 3 4 60
  3. Phosphorylation-dependent activity of the deubiquitinase DUBA. (PMID: 22245969) Huang OW … Cochran AG (Nature structural & molecular biology 2012) 3 4 60
  4. DUBA: a deubiquitinase that regulates type I interferon production. (PMID: 17991829) Kayagaki N … Dixit VM (Science (New York, N.Y.) 2007) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for OTUD5 Gene

  • Addgene plasmids for OTUD5

Sources for OTUD5 Gene

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