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Aliases for OTUD5 Gene

Aliases for OTUD5 Gene

  • OTU Deubiquitinase 5 2 3
  • Deubiquitinating Enzyme A 3 4
  • OTU Domain Containing 5 2 3
  • DUBA 3 4
  • Deubiquinating Enzyme A 3
  • EC 3.4.19.12 4

External Ids for OTUD5 Gene

Previous GeneCards Identifiers for OTUD5 Gene

  • GC0XM048536
  • GC0XM048665
  • GC0XM048779
  • GC0XM046435

Summaries for OTUD5 Gene

Entrez Gene Summary for OTUD5 Gene

  • This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

GeneCards Summary for OTUD5 Gene

OTUD5 (OTU Deubiquitinase 5) is a Protein Coding gene. Among its related pathways are Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD5 Gene

  • Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD5 Gene

Genomics for OTUD5 Gene

Regulatory Elements for OTUD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OTUD5 Gene

Chromosome:
X
Start:
48,922,024 bp from pter
End:
48,958,624 bp from pter
Size:
36,601 bases
Orientation:
Minus strand

Genomic View for OTUD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD5 Gene

Proteins for OTUD5 Gene

  • Protein details for OTUD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G74-OTUD5_HUMAN
    Recommended name:
    OTU domain-containing protein 5
    Protein Accession:
    Q96G74
    Secondary Accessions:
    • B4DGG7
    • G5E9D7
    • Q4KMN9
    • Q8N6T5
    • Q9H650
    • Q9H9U0
    • Q9NT65

    Protein attributes for OTUD5 Gene

    Size:
    571 amino acids
    Molecular mass:
    60626 Da
    Quaternary structure:
    • Interacts with TRAF3.
    SequenceCaution:
    • Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD5 Gene

    Alternative splice isoforms for OTUD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD5 Gene

Proteomics data for OTUD5 Gene at MOPED

Post-translational modifications for OTUD5 Gene

  • Phosphorylation at Ser-177 is required for deubiquitinating activity.
  • Ubiquitination at Lys 205, Lys 219, Lys 253, Lys 343, Lys 356, Lys 370, and Lys 429
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OTUD5

No data available for DME Specific Peptides for OTUD5 Gene

Domains & Families for OTUD5 Gene

Gene Families for OTUD5 Gene

Protein Domains for OTUD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96G74

UniProtKB/Swiss-Prot:

OTUD5_HUMAN :
  • Contains 1 OTU domain.
  • Belongs to the peptidase C85 family.
Domain:
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C85 family.
genes like me logo Genes that share domains with OTUD5: view

Function for OTUD5 Gene

Molecular function for OTUD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethyl-maleimide (NEM)
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards Lys-48- and Lys-63-linked polyubiquitin chains. Can also cleave Lys-11-linked ubiquitin chains (in vitro).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages.

Enzyme Numbers (IUBMB) for OTUD5 Gene

Gene Ontology (GO) - Molecular Function for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 22245969
genes like me logo Genes that share ontologies with OTUD5: view
genes like me logo Genes that share phenotypes with OTUD5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD5 Gene

Localization for OTUD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD5 Gene COMPARTMENTS Subcellular localization image for OTUD5 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD5 Gene

Pathways & Interactions for OTUD5 Gene

genes like me logo Genes that share pathways with OTUD5: view

Pathways by source for OTUD5 Gene

Interacting Proteins for OTUD5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000156084%0d%0a9606.ENSP00000272317%0d%0a9606.ENSP00000376500%0d%0a
Selected Interacting proteins: Q96G74-OTUD5_HUMAN ENSP00000156084 for OTUD5 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016579 protein deubiquitination --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032496 response to lipopolysaccharide IDA 22245969
GO:0045087 innate immune response TAS --
GO:0070536 protein K63-linked deubiquitination IDA 22245969
genes like me logo Genes that share ontologies with OTUD5: view

No data available for SIGNOR curated interactions for OTUD5 Gene

Drugs & Compounds for OTUD5 Gene

No Compound Related Data Available

Transcripts for OTUD5 Gene

Unigene Clusters for OTUD5 Gene

OTU domain containing 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for OTUD5 Gene

GeneLoc Exon Structure for
OTUD5
ECgene alternative splicing isoforms for
OTUD5

Expression for OTUD5 Gene

mRNA expression in normal human tissues for OTUD5 Gene

Protein differential expression in normal tissues from HIPED for OTUD5 Gene

This gene is overexpressed in Retina (43.2) and Fetal Liver (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OTUD5 Gene



SOURCE GeneReport for Unigene cluster for OTUD5 Gene Hs.496098

mRNA Expression by UniProt/SwissProt for OTUD5 Gene

Q96G74-OTUD5_HUMAN
Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with OTUD5: view

Protein tissue co-expression partners for OTUD5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OTUD5 Gene

Orthologs for OTUD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTUD5 35
  • 92.59 (n)
  • 98.77 (a)
OTUD5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD5 35
  • 93.05 (n)
  • 98.95 (a)
OTUD5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud5 16
Otud5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTUD5 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTUD5 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD5 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53520 35
zebrafish
(Danio rerio)
Actinopterygii sibz30i22.1 35
otud5a 36
  • 73 (a)
OneToMany
otud5b 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6091 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea otub-4 36
  • 36 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.4444 35
Species with no ortholog for OTUD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OTUD5 Gene

ENSEMBL:
Gene Tree for OTUD5 (if available)
TreeFam:
Gene Tree for OTUD5 (if available)

Paralogs for OTUD5 Gene

No data available for Paralogs for OTUD5 Gene

Variants for OTUD5 Gene

Sequence variations from dbSNP and Humsavar for OTUD5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2049877 -- 48,927,164(+) AAAAA(C/T)AGTCA intron-variant
rs3027487 -- 48,946,615(-) TGGAC(C/T)ACTGG intron-variant
rs3027488 -- 48,946,567(-) GGAAG(C/T)TCATT intron-variant
rs3027490 -- 48,942,061(-) CCTTC(A/G)GTAAG intron-variant
rs3027498 -- 48,938,306(-) TTGGG(A/G)TAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTUD5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv6894 CNV Insertion 18451855

Variation tolerance for OTUD5 Gene

Residual Variation Intolerance Score: 24.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD5 Gene

HapMap Linkage Disequilibrium report
OTUD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD5 Gene

Disorders for OTUD5 Gene

Relevant External Links for OTUD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD5
genes like me logo Genes that share disorders with OTUD5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD5 Gene

Publications for OTUD5 Gene

  1. OTUD5 regulates p53 stability by deubiquitinating p53. (PMID: 24143256) Luo J. … Zhou X. (PLoS ONE 2013) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress. (PMID: 25499082) Park S.Y. … Yoon H.G. (Cancer Lett. 2015) 67
  4. HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. (PMID: 24763515) Peng Y. … Zheng X. (PLoS Pathog. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for OTUD5 Gene

Sources for OTUD5 Gene

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