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OTUD4 Gene

protein-coding   GIFtS: 52
GCID: GC04M146054

OTU Deubiquitinase 4

(Previous name: OTU domain containing 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase 41 2     DUBA62
HIN12 3 5     HSHIN12
OTU Domain Containing 41 2     HIV-1 Induced Protein HIN-12
HIV-1-Induced Protein HIN-12 3     OTU Domain-Containing Protein 42
KIAA10463 5     EC 3.4.19.123

External Ids:    HGNC: 249491   Entrez Gene: 547262   Ensembl: ENSG000001641647   OMIM: 6117445   UniProtKB: Q018043   

Export aliases for OTUD4 gene to outside databases

Previous GC identifers: GC04M146413 GC04M146274 GC04M141787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTUD4 Gene:
Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by
the shorter transcript variant is found only in HIV-1 infected cells. (provided by RefSeq, Jul 2010)

GeneCards Summary for OTUD4 Gene:
OTUD4 (OTU deubiquitinase 4) is a protein-coding gene. Diseases associated with OTUD4 include hiv-1, and hypogonadotropism. GO annotations related to this gene include ubiquitin-specific protease activity. An important paralog of this gene is ALG13.

UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804
Function: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin

Gene Wiki entry for OTUD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUD4 gene promoter:
         HOXA9B   HOXA9   p300   Tal-1beta   Meis-1b   E47   GATA-2   N-Myc   Sox9   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUD4 promoter sequence
   Search Chromatin IP Primers for OTUD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.21   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.21

OTUD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M146054:  view genomic region     (about GC identifiers)

Start:
146,031,990 bp from pter      End:
146,101,313 bp from pter
Size:
69,324 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804 (See protein sequence)
Recommended Name: OTU domain-containing protein 4  
Size: 1114 amino acids; 124045 Da
Sequence caution: Sequence=AAH57242.2; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the
N-terminal part; Sequence=BAA82998.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAB71229.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DYS4 Q147U2 Q1ZYK1 Q6PG39 Q96MQ5 Q9NT94 Q9UPV6
Alternative splicing: 4 isoforms:  Q01804-1   Q01804-5   Q01804-3   Q01804-4   (Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention)

Explore the universe of human proteins at neXtProt for OTUD4: NX_Q01804

Explore proteomics data for OTUD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OTUD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001096123.1  NP_059963.1  

    ENSEMBL proteins: 
     ENSP00000409279   ENSP00000395487   ENSP00000425972   ENSP00000424192   ENSP00000423453  
     ENSP00000296579  

    OTUD4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals OTUD4 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for OTUD4

    OTUD4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OTUD4
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    OTUD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for OTUD4
    Cloud-Clone Corp. CLIAs for OTUD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    1 InterPro protein domain:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q01804

    ProtoNet protein and cluster: Q01804

    1 Blocks protein domain: IPB003323 OTU-like cysteine protease

    UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804
    Similarity: Contains 1 OTU domain


    OTUD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUD4_HUMAN, Q01804
    Function: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: By HIV-1 insertion

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0044822poly(A) RNA binding IDA--
         
    OTUD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OTUD4:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTUD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTUD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target OTUD4:
    hsa-mir-19b-3p (MIRT031152), hsa-mir-93-5p (MIRT028039), hsa-mir-130b-3p (MIRT020209), hsa-mir-18a-3p (MIRT040879), hsa-mir-183-5p (MIRT024997), hsa-mir-30b-5p (MIRT023436), hsa-mir-101-3p (MIRT027284)

    Block miRNA regulation of human, mouse, rat OTUD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD4 (see all 88):
    hsa-miR-100* hsa-miR-4272 hsa-miR-15a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-3142 hsa-miR-376c hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidOTUD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OTUD4
    Predesigned siRNA for gene silencing in human, mouse, rat OTUD4

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for OTUD4
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    GenScript: all cDNA clones in your preferred vector (see all 2): OTUD4 (NM_017493)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OTUD4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    OTUD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUD4
    Interactions:

        Search GeneGlobe Interaction Network for OTUD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OTUD4 (Q018043 ENSP000004092794) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234096Q166533, ENSP000003918984I2D: score=2 STRING: ENSP00000391898
    ENSG00000137345Q166533I2D: score=2 
    ENSG00000230885Q166533I2D: score=2 
    ENSG00000232641Q166533I2D: score=2 
    ENSG00000234623Q166533I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0071108protein K48-linked deubiquitination IDA--

    OTUD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OTUD4 gene (3 alternative transcripts): 
    NM_001102653.1  NM_017493.6  NM_199324.2  

    Unigene Cluster for OTUD4:

    OTU domain containing 4
    Hs.270851  [show with all ESTs]
    Unigene Representative Sequence: NM_001102653
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455611 ENST00000454497(uc003ika.4) ENST00000447906 ENST00000509517
    ENST00000514973 ENST00000505976 ENST00000509620(uc021xsl.1) ENST00000504501
    ENST00000509985 ENST00000504331 ENST00000296579
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OTUD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD4 (see all 88):
    hsa-miR-100* hsa-miR-4272 hsa-miR-15a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-3142 hsa-miR-376c hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidOTUD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OTUD4
    Predesigned siRNA for gene silencing in human, mouse, rat OTUD4
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    OriGene ORF clones in mouse, rat for OTUD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OTUD4 (NM_017493)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OTUD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTUD4
      QuantiTect SYBR Green Assays in human, mouse, rat OTUD4
      QuantiFast Probe-based Assays in human, mouse, rat OTUD4

    Additional mRNA sequence: 

    AK056597.1 AK302581.1 AL137460.1 BC020682.1 BC057242.1 BC118572.1 BC118653.1 X68242.1 

    11 DOTS entries:

    DT.311285  DT.447767  DT.40312008  DT.202656  DT.121178469  DT.70102334  DT.95114464  DT.95168685 
    DT.100652143  DT.92408187  DT.95094459 

    Selected AceView cDNA sequences (see all 192):

    AB028969 AI076277 BU158872 CA412427 BX348744 CK429777 AI139983 AK056597 
    AL042443 AI081558 BF126137 BF726608 AA443234 BQ425637 BU195063 NM_199324 
    BX489372 AA888030 BQ435300 CA397434 AA363754 AI417087 AI683771 AA363755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGATGCT
    OTUD4 Expression
    About this image


    OTUD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    OTUD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270851
        Custom PCR Arrays for OTUD4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OTUD4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud41 , 5 OTU domain containing 41, 5 88.21(n)1
    87.69(a)1
      8 (37.74 cM)5
    739451  NM_001081164.11  NP_001074633.11 
     796396185 
    chicken
    (Gallus gallus)
    Aves OTUD41 OTU domain containing 4 68.67(n)
    61.82(a)
      422463  XM_420427.3  XP_420427.3 
    lizard
    (Anolis carolinensis)
    Reptilia OTUD46
    OTU domain containing 4
    45(a)
    1 ↔ 1
    5(117906238-117943064)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195812 Transcribed sequence with moderate similarity to protein more 77.63(n)    BX781054.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057511.12   -- 74.05(n)    BC057511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32516
    otu6
    ovarian tumor
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    2L(4688965-4690702)
    X(8379041-8383568)


    ENSEMBL Gene Tree for OTUD4 (if available)
    TreeFam Gene Tree for OTUD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTUD4 gene
    ALG132  
    1 SIMAP similar gene for OTUD4 using alignment to 6 protein entries:     OTUD4_HUMAN (see all proteins):
    ALG13

    OTUD4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OTUD4
    PGOHUM00000258652


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUD4 (see all 943)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849912651,2
    --146054375(+) AAAACA/CCTCAA 1 -- ds50010--------
    rs2009560061,2
    C--146054437(+) AAAAA-/ACAATT 1 -- ds50010--------
    rs362273331,2
    C,F--146054491(-) CTGCAA/GTGACT 1 -- ds50012Minor allele frequency- G:0.01NS 94
    rs1899374481,2
    C--146054601(+) CTCAAC/TTTCGT 1 -- ds50010--------
    rs796296161,2
    F--146054653(+) AATTCT/AACATG 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs362273321,2
    C,F--146054684(-) GAAGAC/TAATTC 1 -- ds50015Minor allele frequency- T:0.05NS WA 306
    rs170199001,2
    C,F,H--146054799(+) AAGCAG/CAATCA 1 -- ds500117Minor allele frequency- C:0.34NA NS EA WA CSA 1014
    rs131430491,2
    H--146054829(+) TGCACA/TCAGTT 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 416
    rs1461305021,2
    --146054838(+) TTTTAG/TATATA 1 -- ut310--------
    rs1925854191,2
    C--146055064(+) AATGAA/TCACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OTUD4 (146031990 - 146101313 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OTUD4: --
    Human Gene Mutation Database (HGMD): OTUD4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUD4
    DNA2.0 Custom Variant and Variant Library Synthesis for OTUD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611744    OMIM disorders: --

    4 diseases for OTUD4:    
    About MalaCards
    hiv-1    hypogonadotropism    dementia    ataxia


    OTUD4 for disorders           About GeneDecksing


    Export disorders for OTUD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUD4 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with OTUD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts. (PubMed id 1475186)1, 2, 3 Raineri I. and Senn H.-P. (Nucleic Acids Res. 1992)
    2. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. (PubMed id 23656588)1, 2 Margolin D.H....Seminara S.B. (N. Engl. J. Med. 2013)
    3. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PubMed id 19996094)1, 3 Li S.... Shu H.B. (J. Biol. Chem. 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    10. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)2 Mevissen T.E.... Komander D. (Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54726 HGNC: 24949 AceView: HSHIN1 Ensembl:ENSG00000164164 euGenes: HUgn54726
    ECgene: OTUD4 H-InvDB: OTUD4

    (According to HUGE)
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    HUGE: KIAA1046

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUD4 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/otud4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUD4 gene:
    Search GeneIP for patents involving OTUD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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