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Aliases for OTUD4 Gene

Aliases for OTUD4 Gene

  • OTU Deubiquitinase 4 2 3 5
  • HIN1 3 4
  • OTU Domain-Containing Protein 4 3
  • HIV-1 Induced Protein HIN-1 3
  • HIV-1-Induced Protein HIN-1 4
  • OTU Domain Containing 4 2
  • EC 4
  • KIAA1046 4
  • HSHIN1 3
  • DUBA6 3

External Ids for OTUD4 Gene

Previous GeneCards Identifiers for OTUD4 Gene

  • GC04M146413
  • GC04M146274
  • GC04M146054
  • GC04M141787

Summaries for OTUD4 Gene

Entrez Gene Summary for OTUD4 Gene

  • Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

GeneCards Summary for OTUD4 Gene

OTUD4 (OTU Deubiquitinase 4) is a Protein Coding gene. Diseases associated with OTUD4 include Hypogonadotropism and Hiv-1. GO annotations related to this gene include poly(A) RNA binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is ALG13.

UniProtKB/Swiss-Prot for OTUD4 Gene

  • Deubiquitinating enzyme that specifically hydrolyzes Lys-48-linked polyubiquitin.

Gene Wiki entry for OTUD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD4 Gene

Genomics for OTUD4 Gene

Regulatory Elements for OTUD4 Gene

Enhancers for OTUD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F145102 0.9 FANTOM5 Ensembl 11.1 +76.8 76804 1.1 ARID1B ZNF263 IKZF1 HMBOX1 KDM1A SPI1 RELA OTUD4 ANAPC10 ENSG00000238713 GC04M145151
GH04F145130 0.8 Ensembl ENCODE 11.5 +49.2 49168 1.6 JUND POLR2A HLF REST SUPT5H OTUD4 ABCE1 ANAPC10 GC04M145151 ENSG00000238713
GH04F145530 0.9 Ensembl ENCODE 9.8 -352.3 -352309 3.5 PKNOX1 CEBPB ATF2 ZNF121 POLR2A SMARCA4 PBX2 MAFK SMAD1-AS2 SMAD1 OTUD4 MMAA SMAD1-AS1 LOC285422
GH04F145132 0.7 ENCODE 11.5 +47.5 47511 1.2 TBL1XR1 MTA2 JUNB RELA POLR2A EED IKZF1 TCF7 STAT3 NBN OTUD4 ABCE1 ANAPC10 GC04M145151 ENSG00000238713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUD4 on UCSC Golden Path with GeneCards custom track

Promoters for OTUD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for OTUD4 Gene

145,110,838 bp from pter
145,180,161 bp from pter
69,324 bases
Minus strand

Genomic View for OTUD4 Gene

Genes around OTUD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD4 Gene

Proteins for OTUD4 Gene

  • Protein details for OTUD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DYS4
    • Q147U2
    • Q1ZYK1
    • Q6PG39
    • Q96MQ5
    • Q9NT94
    • Q9UPV6

    Protein attributes for OTUD4 Gene

    1114 amino acids
    Molecular mass:
    124045 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH57242.2; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA82998.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB71229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OTUD4 Gene


neXtProt entry for OTUD4 Gene

Post-translational modifications for OTUD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OTUD4 Gene

Domains & Families for OTUD4 Gene

Gene Families for OTUD4 Gene

Protein Domains for OTUD4 Gene


Suggested Antigen Peptide Sequences for OTUD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OTU domain.
  • Contains 1 OTU domain.
genes like me logo Genes that share domains with OTUD4: view

Function for OTUD4 Gene

Molecular function for OTUD4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that specifically hydrolyzes Lys-48-linked polyubiquitin.
UniProtKB/Swiss-Prot Induction:
By HIV-1 insertion.

Enzyme Numbers (IUBMB) for OTUD4 Gene

Gene Ontology (GO) - Molecular Function for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 23827681
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD4: view
genes like me logo Genes that share phenotypes with OTUD4: view

Animal Model Products

miRNA for OTUD4 Gene

miRTarBase miRNAs that target OTUD4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD4 Gene

Localization for OTUD4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD4 gene
Compartment Confidence
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OTUD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD4 Gene

Pathways & Interactions for OTUD4 Gene

SuperPathways for OTUD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0071108 protein K48-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD4: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD4 Gene

Transcripts for OTUD4 Gene

Unigene Clusters for OTUD4 Gene

OTU domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD4 Gene

No ASD Table

Relevant External Links for OTUD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OTUD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OTUD4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.2), Fetal ovary (10.2), Tlymphocyte (7.8), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OTUD4 Gene

Protein tissue co-expression partners for OTUD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OTUD4 Gene:


SOURCE GeneReport for Unigene cluster for OTUD4 Gene:

genes like me logo Genes that share expression patterns with OTUD4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD4 Gene

Orthologs for OTUD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OTUD4 34 35
  • 99.65 (n)
(Canis familiaris)
Mammalia OTUD4 34 35
  • 91.37 (n)
(Mus musculus)
Mammalia Otud4 34 16 35
  • 88.21 (n)
(Rattus norvegicus)
Mammalia Otud4 34
  • 86.97 (n)
(Bos Taurus)
Mammalia OTUD4 34 35
  • 85.92 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
-- 35
  • 63 (a)
-- 35
  • 58 (a)
(Monodelphis domestica)
Mammalia OTUD4 35
  • 66 (a)
(Gallus gallus)
Aves OTUD4 34 35
  • 68.67 (n)
(Anolis carolinensis)
Reptilia OTUD4 35
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otud4 34
  • 59.72 (n)
Str.19581 34
(Danio rerio)
Actinopterygii otud4 35
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3251 35
  • 20 (a)
otu 35
  • 18 (a)
Species where no ortholog for OTUD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD4 Gene

Gene Tree for OTUD4 (if available)
Gene Tree for OTUD4 (if available)

Paralogs for OTUD4 Gene

Paralogs for OTUD4 Gene

(1) SIMAP similar genes for OTUD4 Gene using alignment to 6 proteins: Pseudogenes for OTUD4 Gene

genes like me logo Genes that share paralogs with OTUD4: view

Variants for OTUD4 Gene

Sequence variations from dbSNP and Humsavar for OTUD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs147253069 Uncertain significance 145,137,772(+) TCAGC(A/T)GCAGT reference, synonymous-codon
rs148857745 Uncertain significance 145,150,579(+) GTGAC(A/C)CTGAA reference, missense
rs1063614 -- 145,135,918(-) CAGAT(A/G)GGTTT utr-variant-3-prime
rs1063615 -- 145,135,787(-) CTGCT(G/T)ATTTG utr-variant-3-prime
rs10648147 -- 145,140,868(+) AAACA(-/ATT)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD4 Gene

Variant ID Type Subtype PubMed ID
nsv966326 CNV duplication 23825009
nsv1073805 CNV deletion 25765185

Variation tolerance for OTUD4 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD4 Gene

Disorders for OTUD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OTUD4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • hypogonadism
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search OTUD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OTUD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OTUD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OTUD4 Gene

Publications for OTUD4 Gene

  1. HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts. (PMID: 1475186) Raineri I. … Senn H.-P. (Nucleic Acids Res. 1992) 2 3 4 64
  2. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. (PMID: 23656588) Margolin D.H. … Seminara S.B. (N. Engl. J. Med. 2013) 3 4 64
  3. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 3 4 64
  4. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PMID: 19996094) Li S. … Shu H.B. (J. Biol. Chem. 2010) 2 3 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for OTUD4 Gene

Sources for OTUD4 Gene

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