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Aliases for OTUD4 Gene

Aliases for OTUD4 Gene

  • OTU Deubiquitinase 4 2 3
  • HIV-1-Induced Protein HIN-1 3 4
  • OTU Domain Containing 4 2 3
  • HIN1 3 4
  • HIV-1 Induced Protein HIN-1 3
  • EC 3.4.19.12 4
  • KIAA1046 4
  • HSHIN1 3
  • DUBA6 3

External Ids for OTUD4 Gene

Previous GeneCards Identifiers for OTUD4 Gene

  • GC04M146413
  • GC04M146274
  • GC04M146054
  • GC04M141787

Summaries for OTUD4 Gene

Entrez Gene Summary for OTUD4 Gene

  • Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

GeneCards Summary for OTUD4 Gene

OTUD4 (OTU Deubiquitinase 4) is a Protein Coding gene. Diseases associated with OTUD4 include hypogonadotropism and hiv-1. GO annotations related to this gene include poly(A) RNA binding and ubiquitin-specific protease activity. An important paralog of this gene is ALG13.

UniProtKB/Swiss-Prot for OTUD4 Gene

  • Deubiquitinating enzyme that specifically hydrolyzes Lys-48-linked polyubiquitin.

Gene Wiki entry for OTUD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD4 Gene

Genomics for OTUD4 Gene

Regulatory Elements for OTUD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OTUD4 Gene

Chromosome:
4
Start:
145,110,838 bp from pter
End:
145,180,161 bp from pter
Size:
69,324 bases
Orientation:
Minus strand

Genomic View for OTUD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD4 Gene

Proteins for OTUD4 Gene

  • Protein details for OTUD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01804-OTUD4_HUMAN
    Recommended name:
    OTU domain-containing protein 4
    Protein Accession:
    Q01804
    Secondary Accessions:
    • B4DYS4
    • Q147U2
    • Q1ZYK1
    • Q6PG39
    • Q96MQ5
    • Q9NT94
    • Q9UPV6

    Protein attributes for OTUD4 Gene

    Size:
    1114 amino acids
    Molecular mass:
    124045 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57242.2; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA82998.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB71229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OTUD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD4 Gene

Proteomics data for OTUD4 Gene at MOPED

Post-translational modifications for OTUD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD4 Gene

Antibody Products

No data available for DME Specific Peptides for OTUD4 Gene

Domains & Families for OTUD4 Gene

Gene Families for OTUD4 Gene

Protein Domains for OTUD4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01804

UniProtKB/Swiss-Prot:

OTUD4_HUMAN :
  • Contains 1 OTU domain.
Domain:
  • Contains 1 OTU domain.
genes like me logo Genes that share domains with OTUD4: view

Function for OTUD4 Gene

Molecular function for OTUD4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that specifically hydrolyzes Lys-48-linked polyubiquitin.
UniProtKB/Swiss-Prot Induction:
By HIV-1 insertion.

Enzyme Numbers (IUBMB) for OTUD4 Gene

Gene Ontology (GO) - Molecular Function for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 23827681
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with OTUD4: view

Phenotypes for OTUD4 Gene

genes like me logo Genes that share phenotypes with OTUD4: view

Animal Model Products

miRNA for OTUD4 Gene

miRTarBase miRNAs that target OTUD4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD4 Gene

Localization for OTUD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD4 Gene COMPARTMENTS Subcellular localization image for OTUD4 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OTUD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD4 Gene

Pathways & Interactions for OTUD4 Gene

SuperPathways for OTUD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071108 protein K48-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD4: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD4 Gene

Drugs & Compounds for OTUD4 Gene

No Compound Related Data Available

Transcripts for OTUD4 Gene

Unigene Clusters for OTUD4 Gene

OTU domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD4 Gene

No ASD Table

Relevant External Links for OTUD4 Gene

GeneLoc Exon Structure for
OTUD4
ECgene alternative splicing isoforms for
OTUD4

Expression for OTUD4 Gene

mRNA expression in normal human tissues for OTUD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OTUD4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.2), Fetal ovary (10.2), Tlymphocyte (7.8), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OTUD4 Gene



SOURCE GeneReport for Unigene cluster for OTUD4 Gene Hs.270851

genes like me logo Genes that share expression patterns with OTUD4: view

Protein tissue co-expression partners for OTUD4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD4 Gene

Orthologs for OTUD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTUD4 35
  • 85.92 (n)
  • 87.16 (a)
OTUD4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD4 35
  • 91.37 (n)
  • 91.18 (a)
OTUD4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud4 35
  • 88.21 (n)
  • 87.69 (a)
Otud4 16
Otud4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTUD4 35
  • 99.65 (n)
  • 99.43 (a)
OTUD4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otud4 35
  • 86.97 (n)
  • 86.72 (a)
oppossum
(Monodelphis domestica)
Mammalia OTUD4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves OTUD4 35
  • 68.67 (n)
  • 61.82 (a)
OTUD4 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTUD4 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otud4 35
  • 59.72 (n)
  • 49.95 (a)
Str.19581 35
zebrafish
(Danio rerio)
Actinopterygii otud4 36
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3251 36
  • 20 (a)
ManyToMany
otu 36
  • 18 (a)
ManyToMany
Species with no ortholog for OTUD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD4 Gene

ENSEMBL:
Gene Tree for OTUD4 (if available)
TreeFam:
Gene Tree for OTUD4 (if available)

Paralogs for OTUD4 Gene

Paralogs for OTUD4 Gene

(1) SIMAP similar genes for OTUD4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for OTUD4 Gene

genes like me logo Genes that share paralogs with OTUD4: view

Variants for OTUD4 Gene

Sequence variations from dbSNP and Humsavar for OTUD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_029377 -
VAR_038848 -
VAR_070050 -

Variation tolerance for OTUD4 Gene

Residual Variation Intolerance Score: 43.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD4 Gene

HapMap Linkage Disequilibrium report
OTUD4
Human Gene Mutation Database (HGMD)
OTUD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OTUD4 Gene

Disorders for OTUD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OTUD4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypogonadotropism
  • hypogonadism
hiv-1
  • aids, slow progression to
- elite association
Search OTUD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OTUD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD4
genes like me logo Genes that share disorders with OTUD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OTUD4 Gene

Publications for OTUD4 Gene

  1. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PMID: 19996094) Li S. … Shu H.B. (J. Biol. Chem. 2010) 2 67
  2. Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. (PMID: 12727813) Krop I. … Polyak K. (Cancer Res. 2003) 2 67
  3. HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts. (PMID: 1475186) Raineri I. … Senn H.-P. (Nucleic Acids Res. 1992) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. (PMID: 25944111) Zhao Y. … Mosammaparast N. (EMBO J. 2015) 67

Products for OTUD4 Gene

Sources for OTUD4 Gene

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