OTUD4 Gene
protein-coding GIFtS : 48
GCID: GC04 M146054
OTU domain containing 4
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Aliasesfor OTUD4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases OTU Domain Containing 4 1 2 HSHIN11 2 KIAA10461 3 5 HIV-1-Induced Protein HIN-12 3 HIN12 3 5 HIV-1 Induced Protein HIN-12 DUBA61 2 OTU Domain-Containing Protein 42
Export aliases for OTUD4 gene to outside databases Previous GC identifers: GC04M146413 GC04M146274 GC04M141787
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Summariesfor OTUD4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for OTUD4 : Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. (provided by RefSeq, Jul 2010) Gene Wiki entry for OTUD4
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Genomic Viewsfor OTUD4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OTUD4 gene promoter: HOXA9B HOXA9 p300 Tal-1beta Meis-1b E47 GATA-2 N-Myc Sox9 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for OTUD4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat OTUD4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q31.21 Ensembl cytogenetic band: 4q31.21 HGNC cytogenetic band: 4q31.21 OTUD4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M146054: view genomic region
(about GC identifiers )
Start:
146,031,990 bp from pter
End:
146,101,313 bp from pter
Size:
69,324 bases
Orientation:
minus strand
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Proteinsfor OTUD4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804 (See
protein sequence )Recommended Name: OTU domain-containing protein 4 Size : 1113 amino acids; 123916 Da
Sequence caution : Sequence=AAI18573.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI18654.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABD72605.1; Type=Erroneous gene model prediction; Sequence=BAA82998.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAB71229.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Originates from a chimeric transcript in HIV-1-infected cells. The premature stop may be due to intron retention;
Secondary accessions : B4DYS4 Q147U2 Q1ZYK1 Q6PG39 Q96MQ5 Q9NT94 Q9UPV6Alternative splicing : 4 isoforms : Q01804-1 Q01804-2 Q01804-4 Q01804-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OTUD4: NX_Q01804 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q01804 OTUD4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001096123.1 NP_059963.1 ENSEMBL proteins: ENSP00000409279 ENSP00000395487 ENSP00000425972 ENSP00000424192 ENSP00000423453 ENSP00000296579 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND --
OTUD4 for ontologies About GeneDecksing OTUD4 Antibody Products: Assay Products for OTUD4:
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Protein
Domains / Familiesfor OTUD4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OTUD4 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q01804 ProtoNet protein and cluster: Q01804
1 Blocks protein family : IPB003323 OTU-like cysteine protease UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804 Similarity : Contains 1 OTU domain
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Functionfor OTUD4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: OTUD4_HUMAN, Q01804 Induction : By HIV-1 insertion
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): OTUD4 (NM_017493 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTUD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OTUD4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD4
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
OTUD4 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for OTUD4 :
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Pathways & Interactionsfor OTUD4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTUD4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/38 Interacting proteins for OTUD4 (Q01804 3 ENSP00000409279 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 38 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
OTUD4 for ontologies About GeneDecksing
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Drugs & Compoundsfor OTUD4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OTUD4 Search CenterWatch for drugs/clinical trials and news about OTUD4
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Transcriptsfor OTUD4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OTUD4 gene (3 alternative transcripts): NM_001102653.1 NM_017493.6 NM_199324.2 Unigene Cluster for OTUD4:
OTU domain containing 4 Hs.270851 [show with all ESTs ] Unigene Representative Sequence: NM_001102653 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000455611 ENST00000454497 (uc003ika.4 ) ENST00000447906 ENST00000509517 ENST00000514973 ENST00000505976 ENST00000509620 (uc021xsl.1 ) ENST00000504501 ENST00000509985 ENST00000504331 ENST00000296579 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): OTUD4 (NM_017493 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTUD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OTUD4
Additional cDNA sequence: AK056597.1 AK302581.1 AL137460.1 BC020682.1 BC057242.1 BC118572.1 BC118653.1 X68242.1
11 DOTS entries : DT.311285 DT.447767
DT.40312008 DT.202656 DT.121178469 DT.70102334 DT.95114464 DT.95168685 DT.100652143 DT.92408187 DT.95094459 24/192 AceView cDNA sequences (see all 192 ):
BF726608 AI074703 AA382637 AI081558 AA634121 BM471766 BX489372 BF126137 AK056597 AB028969 AA371189 CA397434 BQ435300 AI139983 AI081525 BQ436647 AA363754 AA888030 AI076277 AI417087 CK429593 AI683771 CR592200 AW612484 GeneLoc Exon Structure
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Expression for OTUD4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OTUD4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGTGATGCT
About this image OTUD4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See OTUD4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OTUD4 SOURCE GeneReport for Unigene cluster: Hs.270851 SABiosciences Custom PCR Arrays for OTUD4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OTUD4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat OTUD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OTUD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OTUD4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD4
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Orthologsfor OTUD4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for OTUD4 gene from 6/16 species (see all 16 ) About this table
ENSEMBL Gene Tree for OTUD4 (if available)TreeFam Gene Tree for OTUD4 (if available)
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Paralogsfor OTUD4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OTUD4 gene ALG13 2 2 SIMAP similar genes for OTUD4 using alignment to 6 protein entries: OTUD4_HUMAN (see all proteins ):HIN1L ALG13
OTUD4 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for OTUD4 PGOHUM00000258652
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Genomic Variantsfor OTUD4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OTUD4
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Disorders
/ Diseasesfor OTUD4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
OTUD4 for disorders About MalaCards
OTUD4 for disorders About GeneDecksing
OMIM gene information: 611744
OMIM disorders : --Export disorders for OTUD4 gene to outside databases
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Publicationsfor OTUD4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OTUD4 gene, integrated from 9 sources (see all 28 ): (articles sorted by number of sources associating them with OTUD4) Utopia : connect your pdf to the dynamic world of online information
HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts. (PubMed id 1475186) 1 , 2 , 3 Raineri I. and Senn H.-P. (1992) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186) 1 , 2 Brill L.M....Peters E.C. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851) 1 , 2 Kikuno R....Ohara O. (1999) Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844) 1 Wu Z....Ma L. (2012) Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606) 1 Lin Y.Y....Boeke J.D. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011)
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External Searches for OTUD4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OTUD4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OTUD4 gene
(According to HUGE )
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Specialized Databases showing OTUD4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for OTUD4 Pharmacogenomics, SNPs, Pathways SeattleSNPs http://pga.gs.washington.edu/data/otud4/
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About This Section Patent Information for OTUD4 gene: Search GeneIP for patents involving OTUD4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OTUD4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for OTUD4 OriGene shRNA RFP for OTUD4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for OTUD4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OTUD4 OriGene Protein Over-expression Lysate for OTUD4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OTUD4 OriGene 3'-UTR Clone for OTUD4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OTUD4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OTUD4 OriGene Custom Protein Services for OTUD4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OTUD4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OTUD4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat OTUD4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat OTUD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OTUD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OTUD4
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OTUD4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD4
ThermoFisher Antibodies for OTUD4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OTUD4
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Aliases for OTUD4
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Disorders / Diseases for OTUD4
Domains / Families for OTUD4
Drugs / Compounds for OTUD4
Expression for OTUD4
Function for OTUD4
Genomic Views for OTUD4
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Orthologs for OTUD4
Paralogs for OTUD4
Pathways / Interactions for OTUD4
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Summaries for OTUD4
Transcripts for OTUD4
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