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Aliases for OTUD3 Gene

Aliases for OTUD3 Gene

  • OTU Deubiquitinase 3 2 3 5
  • OTU Domain Containing 3 2 3
  • OTU Domain-Containing Protein 3 3
  • EC 3.4.19.12 4
  • KIAA0459 4
  • DUBA4 3

External Ids for OTUD3 Gene

Previous GeneCards Identifiers for OTUD3 Gene

  • GC01P019977
  • GC01P020081
  • GC01P020208
  • GC01P018454

Summaries for OTUD3 Gene

GeneCards Summary for OTUD3 Gene

OTUD3 (OTU Deubiquitinase 3) is a Protein Coding gene. Among its related pathways are Deubiquitination and Protein ubiquitination. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD3 Gene

  • Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD3 Gene

Genomics for OTUD3 Gene

Regulatory Elements for OTUD3 Gene

Enhancers for OTUD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G019642 1.6 Ensembl ENCODE dbSUPER 23.6 -233.1 -233061 11.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 OTUD3 EMC1 HTR6 NBL1 GC01M019654
GH01G018901 1.4 ENCODE dbSUPER 25.2 -978.9 -978850 3.6 HDGF PKNOX1 FOXA2 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 OTUD3 EMC1 IFFO2 ALDH4A1 ENSG00000255275
GH01G019871 1 ENCODE 32.8 -9.2 -9168 1.3 ATF1 PKNOX1 ARNT TCF12 ZNF766 GATA2 ELK1 FOS NCOA1 REST OTUD3 EMC1 PIR53184 GC01M019829
GH01G019432 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -429.9 -429861 39.4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 MEF2D SSRP1 RCOR2 CAPZB NBL1 OTUD3 RNU4-28P EMC1 HTR6 AKR7A2 AKR7A3 PQLC2 UBR4
GH01G019812 1.4 Ensembl ENCODE dbSUPER 16.7 -66.6 -66642 5.3 ELF3 NFIB ZNF133 ARID4B FEZF1 ZSCAN9 RAD21 RARA YY1 SLC30A9 OTUD3 TMCO4 ENSG00000235434 RNF186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUD3 on UCSC Golden Path with GeneCards custom track

Promoters for OTUD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002529 1098 1201 PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for OTUD3 Gene

Chromosome:
1
Start:
19,881,702 bp from pter
End:
19,912,945 bp from pter
Size:
31,244 bases
Orientation:
Plus strand

Genomic View for OTUD3 Gene

Genes around OTUD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD3 Gene

Proteins for OTUD3 Gene

  • Protein details for OTUD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D3-OTUD3_HUMAN
    Recommended name:
    OTU domain-containing protein 3
    Protein Accession:
    Q5T2D3
    Secondary Accessions:
    • O75047

    Protein attributes for OTUD3 Gene

    Size:
    398 amino acids
    Molecular mass:
    45124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32304.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD3 Gene

neXtProt entry for OTUD3 Gene

Post-translational modifications for OTUD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD3 Gene

No data available for DME Specific Peptides for OTUD3 Gene

Domains & Families for OTUD3 Gene

Gene Families for OTUD3 Gene

Protein Domains for OTUD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2D3

UniProtKB/Swiss-Prot:

OTUD3_HUMAN :
  • The UBA-like domain has no influence on ubiquitin hydrolysis.
Domain:
  • The UBA-like domain has no influence on ubiquitin hydrolysis.
  • Specificity is given by the S1 ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops.
genes like me logo Genes that share domains with OTUD3: view

Function for OTUD3 Gene

Molecular function for OTUD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

Enzyme Numbers (IUBMB) for OTUD3 Gene

Gene Ontology (GO) - Molecular Function for OTUD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP 26280536
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS --
genes like me logo Genes that share ontologies with OTUD3: view
genes like me logo Genes that share phenotypes with OTUD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OTUD3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD3 Gene

Localization for OTUD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD3 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for OTUD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 26280536
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD3 Gene

Pathways & Interactions for OTUD3 Gene

genes like me logo Genes that share pathways with OTUD3: view

Pathways by source for OTUD3 Gene

Interacting Proteins for OTUD3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364261%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000361021%0d%0a
Selected Interacting proteins: ENSP00000364261 Q5T2D3-OTUD3_HUMAN for OTUD3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OTUD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination TAS --
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:0044313 protein K6-linked deubiquitination IDA 23827681
GO:0050821 protein stabilization IMP 26280536
genes like me logo Genes that share ontologies with OTUD3: view

No data available for SIGNOR curated interactions for OTUD3 Gene

Drugs & Compounds for OTUD3 Gene

No Compound Related Data Available

Transcripts for OTUD3 Gene

Unigene Clusters for OTUD3 Gene

OTU domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OTUD3

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD3 Gene

No ASD Table

Relevant External Links for OTUD3 Gene

GeneLoc Exon Structure for
OTUD3
ECgene alternative splicing isoforms for
OTUD3

Expression for OTUD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTUD3 Gene

Protein differential expression in normal tissues from HIPED for OTUD3 Gene

This gene is overexpressed in Testis (35.0) and Adipocyte (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OTUD3 Gene



Protein tissue co-expression partners for OTUD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OTUD3 Gene:

OTUD3

SOURCE GeneReport for Unigene cluster for OTUD3 Gene:

Hs.374987

Evidence on tissue expression from TISSUES for OTUD3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with OTUD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD3 Gene

Orthologs for OTUD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTUD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD3 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia OTUD3 34 35
  • 91.96 (n)
cow
(Bos Taurus)
Mammalia OTUD3 34 35
  • 90.26 (n)
mouse
(Mus musculus)
Mammalia Otud3 34 16 35
  • 84.43 (n)
rat
(Rattus norvegicus)
Mammalia Otud3 34
  • 84.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves OTUD3 34 35
  • 69.06 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia otud3 34
  • 64.84 (n)
zebrafish
(Danio rerio)
Actinopterygii otud3 34 35
  • 58.82 (n)
Species where no ortholog for OTUD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD3 Gene

ENSEMBL:
Gene Tree for OTUD3 (if available)
TreeFam:
Gene Tree for OTUD3 (if available)

Paralogs for OTUD3 Gene

No data available for Paralogs for OTUD3 Gene

Variants for OTUD3 Gene

Sequence variations from dbSNP and Humsavar for OTUD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000159544 -- 19,887,390(+) ATGAT(C/T)TCTCA intron-variant
rs1000250696 -- 19,904,142(+) CTTAA(A/G)GTTGT intron-variant
rs1000379440 -- 19,893,955(+) TTCTG(C/T)ATCTG intron-variant
rs1000401320 -- 19,912,351(+) TCACA(C/T)ATTTT utr-variant-3-prime
rs1000456536 -- 19,880,899(+) CACCC(A/G)TATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTUD3 Gene

Variant ID Type Subtype PubMed ID
nsv1003518 CNV loss 25217958
nsv460717 CNV loss 19166990
nsv545730 CNV loss 21841781

Variation tolerance for OTUD3 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD3 Gene

Disorders for OTUD3 Gene

Relevant External Links for OTUD3

Genetic Association Database (GAD)
OTUD3
Human Genome Epidemiology (HuGE) Navigator
OTUD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD3

No disorders were found for OTUD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD3 Gene

Publications for OTUD3 Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4 64
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3 46 64
  4. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3 46 64
  5. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg M.S. … Duerr R.H. (Nat. Genet. 2009) 3 46 64

Products for OTUD3 Gene

  • Addgene plasmids for OTUD3

Sources for OTUD3 Gene

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