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OTUD3 Gene

protein-coding   GIFtS: 50
GCID: GC01P020208

OTU Deubiquitinase 3

(Previous name: OTU domain containing 3)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase 31 2
OTU Domain Containing 31 2
KIAA04593 5
DUBA42
OTU Domain-Containing Protein 32
EC 3.4.19.123

External Ids:    HGNC: 290381   Entrez Gene: 232522   Ensembl: ENSG000001699147   OMIM: 6117585   UniProtKB: Q5T2D33   

Export aliases for OTUD3 gene to outside databases

Previous GC identifers: GC01P019977 GC01P020081 GC01P018454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OTUD3 Gene:
OTUD3 (OTU deubiquitinase 3) is a protein-coding gene. Diseases associated with OTUD3 include ulcerative colitis, and hiv-1. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot: OTUD3_HUMAN, Q5T2D3
Function: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes
heterotypic (mixed and branched) and homotypic chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUD3 gene promoter:
         AP-2rep   STAT1   Elk-1   Pax-5   GATA-3   CUTL1   GATA-1   GATA-2   Evi-1   S8   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OTUD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

OTUD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P020208:  view genomic region     (about GC identifiers)

Start:
20,208,888 bp from pter      End:
20,239,438 bp from pter
Size:
30,551 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OTUD3_HUMAN, Q5T2D3 (See protein sequence)
Recommended Name: OTU domain-containing protein 3  
Size: 398 amino acids; 45124 Da
Sequence caution: Sequence=BAA32304.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for OTUD3:
4BOU (3D)    
Secondary accessions: O75047

Explore the universe of human proteins at neXtProt for OTUD3: NX_Q5T2D3

Explore proteomics data for OTUD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OTUD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056022.1  
    ENSEMBL proteins: 
     ENSP00000364261  

    OTUD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for OTUD3
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OTUD3
    OriGene Protein Over-expression Lysate for OTUD3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OTUD3
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    Novus Biologicals OTUD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OTUD3

    OTUD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals OTUD3 Antibodies
    Abcam antibodies for OTUD3
    Cloud-Clone Corp. Antibodies for OTUD3
    ThermoFisher Antibodies for OTUD3
    LSBio Antibodies in human, mouse, rat for OTUD3

    OTUD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OTUD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OTUD3
    Cloud-Clone Corp. CLIAs for OTUD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    1 InterPro protein domain:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q5T2D3

    ProtoNet protein and cluster: Q5T2D3

    UniProtKB/Swiss-Prot: OTUD3_HUMAN, Q5T2D3
    Domain: The UBA-like domain has no influence on ubiquitin hydrolysis (PubMed:23827681)
    Domain: Specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His-
    and Variable-loops (PubMed:23827681)
    Similarity: Contains 1 OTU domain
    Similarity: Contains 1 UBA-like domain


    OTUD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUD3_HUMAN, Q5T2D3
    Function: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes
    heterotypic (mixed and branched) and homotypic chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
         
    OTUD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OTUD3:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OTUD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTUD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTUD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target OTUD3:
    hsa-mir-192-5p (MIRT026967)

    Block miRNA regulation of human, mouse, rat OTUD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD3 (see all 101):
    hsa-miR-300 hsa-miR-376b hsa-miR-106a hsa-miR-200a hsa-miR-219-5p hsa-miR-93 hsa-miR-3613-3p hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OTUD3
    Predesigned siRNA for gene silencing in human, mouse, rat OTUD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OTUD3

    Clone
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    OriGene clones in human, mouse for OTUD3 (see all 7)
    OriGene ORF clones in mouse, rat for OTUD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTUD3 (NM_015207)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OTUD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for OTUD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUD3
    Interactions:

        Search GeneGlobe Interaction Network for OTUD3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for OTUD3 (ENSP000003642614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUF60ENSP000003220164STRING: ENSP00000322016
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0035871protein K11-linked deubiquitination IDA--
    GO:0044313protein K6-linked deubiquitination IDA--

    OTUD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OTUD3 gene: 
    NM_015207.1  

    Unigene Cluster for OTUD3:

    OTU domain containing 3
    Hs.374987  [show with all ESTs]
    Unigene Representative Sequence: NM_015207
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375120(uc001bcs.4) ENST00000466697 ENST00000481686

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OTUD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD3 (see all 101):
    hsa-miR-300 hsa-miR-376b hsa-miR-106a hsa-miR-200a hsa-miR-219-5p hsa-miR-93 hsa-miR-3613-3p hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OTUD3
    Predesigned siRNA for gene silencing in human, mouse, rat OTUD3
    Clone
    Products:
         
    OriGene clones in human, mouse for OTUD3 (see all 7)
    OriGene ORF clones in mouse, rat for OTUD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTUD3 (NM_015207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OTUD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTUD3
      QuantiTect SYBR Green Assays in human, mouse, rat OTUD3
      QuantiFast Probe-based Assays in human, mouse, rat OTUD3

    Additional mRNA sequence: 

    AB007928.3 BC119636.2 BC134416.1 

    3 DOTS entries:

    DT.95256116  DT.95150968  DT.100718781 

    Selected AceView cDNA sequences (see all 56):

    F12671 BQ930494 CR609865 BU608539 AI560700 AI859905 AL537464 BU187452 
    AI142801 CD674028 AI582693 BM969728 AI191035 AB007928 BX484822 AA515223 
    CR613908 AI659298 AW628652 F10283 BG546205 BX472194 AI277456 AI092160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTCGTGAT
    OTUD3 Expression
    About this image

    OTUD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUD3 Protein Expression

    Genevestigator expression for OTUD3

    SOURCE GeneReport for Unigene cluster: Hs.374987
        Custom PCR Arrays for OTUD3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OTUD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTUD3
    QuantiTect SYBR Green Assays in human, mouse, rat OTUD3
    QuantiFast Probe-based Assays in human, mouse, rat OTUD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OTUD3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud31 , 5 OTU domain containing 31, 5 84.43(n)1
    83.33(a)1
      4 (70.57 cM)5
    731621  NM_028453.11  NP_082729.11 
     1388953795 
    chicken
    (Gallus gallus)
    Aves OTUD31 OTU domain containing 3 69.06(n)
    64.36(a)
      426746  XM_424363.4  XP_424363.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia otud31 OTU domain containing 3 64.84(n)
    63.28(a)
      448607  NM_001005056.1  NP_001005056.1 
    zebrafish
    (Danio rerio)
    Actinopterygii otud31 OTU domain containing 3 58.82(n)
    56.3(a)
      405858  NM_212922.1  NP_998087.1 


    ENSEMBL Gene Tree for OTUD3 (if available)
    TreeFam Gene Tree for OTUD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUD3 (see all 616)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901135381,2
    --20206891(+) CAAGTA/GTTCGC 1 -- us2k10--------
    rs1440308431,2
    --20206919(+) AGCAGA/TCTGTA 1 -- us2k10--------
    rs754087391,2
    C,F--20207074(+) TTTATT/GTAATC 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs788876801,2
    C,F--20207080(+) TAATCT/GTTACA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs115796251,2
    C,F,H--20207105(+) TCTTAT/CTGtca 1 -- us2k111Minor allele frequency- C:0.05NS EA NA WA 682
    rs1169516441,2
    C,F--20207188(+) AAAAAT/CAGCAG 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1821097481,2
    --20207364(+) ATATAG/TCGTTC 1 -- us2k10--------
    rs109166631,2
    C,F,A,H--20207622(+) ctgcaC/Tgttct 1 -- us2k19Minor allele frequency- T:0.29NA WA CSA EA 370
    rs1142345921,2
    C--20207807(+) CCTCAC/TGCAAT 1 -- us2k10--------
    rs1879190341,2
    --20208027(+) ATCTCC/GGCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OTUD3 (20208888 - 20239438 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OTUD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv460717CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUD3
    DNA2.0 Custom Variant and Variant Library Synthesis for OTUD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611758    OMIM disorders: --

    2 diseases for OTUD3:    About MalaCards
    ulcerative colitis    hiv-1


    OTUD3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): OTUD3
    Human Genome Epidemiology (HuGE) Navigator: OTUD3 (2 documents)

    Export disorders for OTUD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUD3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with OTUD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)1, 2, 3 Mevissen T.E.... Komander D. (Cell 2013)
    2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (DNA Res. 1997)
    3. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    4. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1, 4 Franke A....Schreiber S. (Nat. Genet. 2010)
    5. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1, 4 Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)
    6. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)1, 4  ....Strachan D.P. (Nat. Genet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. (PubMed id 23511034)1 Yang S.K....Song K. (Inflamm. Bowel Dis. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23252 HGNC: 29038 AceView: KIAA0459 Ensembl:ENSG00000169914 euGenes: HUgn23252
    ECgene: OTUD3 H-InvDB: OTUD3

    (According to HUGE)
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    HUGE: KIAA0459

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUD3 gene:
    Search GeneIP for patents involving OTUD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for OTUD3 (OTUD3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OTUD3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OTUD3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OTUD3  
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     OriGene ORF clones in mouse, rat for OTUD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OTUD3   OriGene Custom Protein Services for OTUD3  

     
     
     Block miRNA regulation of human, mouse, rat OTUD3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OTUD3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD3 Predesigned siRNA for gene silencing in human, mouse, rat OTUD3
     QuantiFast Probe-based Assays in human, mouse, rat OTUD3 QuantiTect SYBR Green Assays in human, mouse, rat OTUD3
     Custom PCR Arrays for OTUD3 Search Chromatin IP Primers for OTUD3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTUD3  Search GeneGlobe Interaction Network for OTUD3
     Regulatory tfbs in OTUD3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OTUD3 GenScript cDNA clones with any tag delivered in your preferred vector for OTUD3
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search Tocris compounds for OTUD3
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for OTUD3
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     Proteins for OTUD3
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OTUD3
     Gene Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for OTUD3
     Browse SwitchGear Promoter luciferase reporter plasmids for OTUD3
     ThermoFisher Antibodies for OTUD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUD3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUD3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OTUD3
     LSBio Antibodies in human, mouse, rat for OTUD3
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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