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Aliases for OTUD3 Gene

Aliases for OTUD3 Gene

  • OTU Deubiquitinase 3 2 3
  • OTU Domain Containing 3 2 3
  • KIAA0459 4 6
  • OTU Domain-Containing Protein 3 3
  • EC 4
  • DUBA4 3

External Ids for OTUD3 Gene

Previous GeneCards Identifiers for OTUD3 Gene

  • GC01P019977
  • GC01P020081
  • GC01P020208
  • GC01P018454

Summaries for OTUD3 Gene

GeneCards Summary for OTUD3 Gene

OTUD3 (OTU Deubiquitinase 3) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD3 Gene

  • Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD3 Gene

Genomics for OTUD3 Gene

Regulatory Elements for OTUD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OTUD3 Gene

19,881,863 bp from pter
19,912,945 bp from pter
31,083 bases
Plus strand

Genomic View for OTUD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD3 Gene

Proteins for OTUD3 Gene

  • Protein details for OTUD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • O75047

    Protein attributes for OTUD3 Gene

    398 amino acids
    Molecular mass:
    45124 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32304.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD3 Gene

neXtProt entry for OTUD3 Gene

Proteomics data for OTUD3 Gene at MOPED

Post-translational modifications for OTUD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OTUD3 Gene

Domains for OTUD3 Gene

Gene Families for OTUD3 Gene

Protein Domains for OTUD3 Gene


Suggested Antigen Peptide Sequences for OTUD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The UBA-like domain has no influence on ubiquitin hydrolysis.
  • The UBA-like domain has no influence on ubiquitin hydrolysis.
  • Specificity is given by the S1 ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops.
  • Contains 1 OTU domain.
  • Contains 1 UBA-like domain.
genes like me logo Genes that share domains with OTUD3: view

Function for OTUD3 Gene

Molecular function for OTUD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

Enzyme Numbers (IUBMB) for OTUD3 Gene

Gene Ontology (GO) - Molecular Function for OTUD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 23827681
genes like me logo Genes that share ontologies with OTUD3: view

Phenotypes for OTUD3 Gene

GenomeRNAi human phenotypes for OTUD3:
genes like me logo Genes that share phenotypes with OTUD3: view

Animal Model Products

miRNA for OTUD3 Gene

miRTarBase miRNAs that target OTUD3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD3 Gene

Localization for OTUD3 Gene

Subcellular locations from

Jensen Localization Image for OTUD3 Gene COMPARTMENTS Subcellular localization image for OTUD3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD3 Gene

Pathways for OTUD3 Gene

SuperPathways for OTUD3 Gene

No Data Available

Interacting Proteins for OTUD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364261 for OTUD3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for OTUD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:0044313 protein K6-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD3: view

No data available for Pathways by source for OTUD3 Gene

Transcripts for OTUD3 Gene

Unigene Clusters for OTUD3 Gene

OTU domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OTUD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD3 Gene

No ASD Table

Relevant External Links for OTUD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD3 Gene

mRNA expression in normal human tissues for OTUD3 Gene

Protein differential expression in normal tissues for OTUD3 Gene

This gene is overexpressed in Testis (35.0) and Adipocyte (31.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for OTUD3 Gene

SOURCE GeneReport for Unigene cluster for OTUD3 Gene Hs.374987

genes like me logo Genes that share expressions with OTUD3: view

Expression partners for OTUD3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD3 Gene

Orthologs for OTUD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTUD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OTUD3 35
  • 90.26 (n)
  • 90.18 (a)
OTUD3 36
  • 82 (a)
(Canis familiaris)
Mammalia OTUD3 35
  • 91.96 (n)
  • 94.22 (a)
OTUD3 36
  • 94 (a)
(Mus musculus)
Mammalia Otud3 35
  • 84.43 (n)
  • 83.33 (a)
Otud3 16
Otud3 36
  • 83 (a)
(Pan troglodytes)
Mammalia OTUD3 35
  • 99.25 (n)
  • 99.5 (a)
OTUD3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Otud3 35
  • 84.23 (n)
  • 81.33 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 79 (a)
(Gallus gallus)
Aves OTUD3 35
  • 69.06 (n)
  • 64.36 (a)
OTUD3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otud3 35
  • 64.84 (n)
  • 63.28 (a)
(Danio rerio)
Actinopterygii otud3 35
  • 58.82 (n)
  • 56.3 (a)
otud3 36
  • 56 (a)
Species with no ortholog for OTUD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD3 Gene

Gene Tree for OTUD3 (if available)
Gene Tree for OTUD3 (if available)

Paralogs for OTUD3 Gene

No data available for Paralogs for OTUD3 Gene

Variants for OTUD3 Gene

Sequence variations from dbSNP and Humsavar for OTUD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs878235 -- 19,882,332(-) TTGCG(C/G)GGCTC upstream-variant-2KB, reference, missense
rs1046548 -- 19,911,850(+) ACCGC(A/G)CACCG utr-variant-3-prime
rs1339717 -- 19,896,007(-) GAGAA(C/T)ACTAC intron-variant
rs1892477 -- 19,904,051(-) AAGAC(A/G)GAATA intron-variant
rs2298110 - 19,906,558(+) AAACA(A/G)TAAGG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD3 Gene

Variant ID Type Subtype PubMed ID
nsv460717 CNV Loss 19166990

Relevant External Links for OTUD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD3 Gene

Disorders for OTUD3 Gene

Relevant External Links for OTUD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for OTUD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OTUD3 Gene

Publications for OTUD3 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4
  3. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg M.S. … Duerr R.H. (Nat. Genet. 2009) 3 48
  4. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PMID: 19915572) . … Strachan D.P. (Nat. Genet. 2009) 3 48
  5. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3 48

Products for OTUD3 Gene

  • Addgene plasmids for OTUD3

Sources for OTUD3 Gene

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