Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OTUD3 Gene

Aliases for OTUD3 Gene

  • OTU Deubiquitinase 3 2 3 5
  • OTU Domain Containing 3 2 3
  • EC 3.4.19.12 4
  • KIAA0459 4
  • DUBA4 3

External Ids for OTUD3 Gene

Previous GeneCards Identifiers for OTUD3 Gene

  • GC01P019977
  • GC01P020081
  • GC01P020208
  • GC01P018454

Summaries for OTUD3 Gene

GeneCards Summary for OTUD3 Gene

OTUD3 (OTU Deubiquitinase 3) is a Protein Coding gene. Among its related pathways are Ubiquitination Cascade Pathway. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD3 Gene

  • Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD3 Gene

Genomics for OTUD3 Gene

Regulatory Elements for OTUD3 Gene

Promoters for OTUD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OTUD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OTUD3 Gene

Chromosome:
1
Start:
19,881,702 bp from pter
End:
19,912,945 bp from pter
Size:
31,244 bases
Orientation:
Plus strand

Genomic View for OTUD3 Gene

Genes around OTUD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD3 Gene

Proteins for OTUD3 Gene

  • Protein details for OTUD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D3-OTUD3_HUMAN
    Recommended name:
    OTU domain-containing protein 3
    Protein Accession:
    Q5T2D3
    Secondary Accessions:
    • O75047

    Protein attributes for OTUD3 Gene

    Size:
    398 amino acids
    Molecular mass:
    45124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32304.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD3 Gene

neXtProt entry for OTUD3 Gene

Proteomics data for OTUD3 Gene at MOPED

Post-translational modifications for OTUD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD3 Gene

Domains & Families for OTUD3 Gene

Gene Families for OTUD3 Gene

Protein Domains for OTUD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2D3

UniProtKB/Swiss-Prot:

OTUD3_HUMAN :
  • The UBA-like domain has no influence on ubiquitin hydrolysis.
Domain:
  • The UBA-like domain has no influence on ubiquitin hydrolysis.
  • Specificity is given by the S1 ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops.
  • Contains 1 OTU domain.
  • Contains 1 UBA-like domain.
genes like me logo Genes that share domains with OTUD3: view

Function for OTUD3 Gene

Molecular function for OTUD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

Enzyme Numbers (IUBMB) for OTUD3 Gene

genes like me logo Genes that share phenotypes with OTUD3: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD3 Gene

Localization for OTUD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTUD3 Gene COMPARTMENTS Subcellular localization image for OTUD3 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD3 Gene

Pathways & Interactions for OTUD3 Gene

SuperPathways for OTUD3 Gene

genes like me logo Genes that share pathways with OTUD3: view

Pathways by source for OTUD3 Gene

1 R&D Systems pathway for OTUD3 Gene

Interacting Proteins for OTUD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364261%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000364261 for OTUD3 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for OTUD3 Gene

None

No data available for SIGNOR curated interactions for OTUD3 Gene

Drugs & Compounds for OTUD3 Gene

No Compound Related Data Available

Transcripts for OTUD3 Gene

Unigene Clusters for OTUD3 Gene

OTU domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD3 Gene

No ASD Table

Relevant External Links for OTUD3 Gene

GeneLoc Exon Structure for
OTUD3
ECgene alternative splicing isoforms for
OTUD3

Expression for OTUD3 Gene

mRNA expression in normal human tissues for OTUD3 Gene

Protein differential expression in normal tissues from HIPED for OTUD3 Gene

This gene is overexpressed in Testis (35.0) and Adipocyte (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for OTUD3 Gene



SOURCE GeneReport for Unigene cluster for OTUD3 Gene Hs.374987

genes like me logo Genes that share expression patterns with OTUD3: view

Protein tissue co-expression partners for OTUD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD3 Gene

Orthologs for OTUD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTUD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTUD3 35
  • 90.26 (n)
  • 90.18 (a)
OTUD3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTUD3 35
  • 91.96 (n)
  • 94.22 (a)
OTUD3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otud3 35
  • 84.43 (n)
  • 83.33 (a)
Otud3 16
Otud3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTUD3 35
  • 99.25 (n)
  • 99.5 (a)
OTUD3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otud3 35
  • 84.23 (n)
  • 81.33 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves OTUD3 35
  • 69.06 (n)
  • 64.36 (a)
OTUD3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otud3 35
  • 64.84 (n)
  • 63.28 (a)
zebrafish
(Danio rerio)
Actinopterygii otud3 35
  • 58.82 (n)
  • 56.3 (a)
otud3 36
  • 56 (a)
OneToOne
Species with no ortholog for OTUD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD3 Gene

ENSEMBL:
Gene Tree for OTUD3 (if available)
TreeFam:
Gene Tree for OTUD3 (if available)

Paralogs for OTUD3 Gene

No data available for Paralogs for OTUD3 Gene

Variants for OTUD3 Gene

Sequence variations from dbSNP and Humsavar for OTUD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2298110 - 19,906,558(+) AAACA(A/G)TAAGG intron-variant, reference, missense
rs10916668 - 19,906,593(+) ACAAA(A/G)CAAAT intron-variant, reference, missense
rs1046548 -- 19,911,850(+) ACCGC(A/G)CACCG utr-variant-3-prime
rs1339717 -- 19,896,007(-) GAGAA(C/T)ACTAC intron-variant
rs1892477 -- 19,904,051(-) AAGAC(A/G)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD3 Gene

Variant ID Type Subtype PubMed ID
nsv460717 CNV Loss 19166990

Variation tolerance for OTUD3 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD3 Gene

HapMap Linkage Disequilibrium report
OTUD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD3 Gene

Disorders for OTUD3 Gene

Relevant External Links for OTUD3

Genetic Association Database (GAD)
OTUD3
Human Genome Epidemiology (HuGE) Navigator
OTUD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD3

No disorders were found for OTUD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD3 Gene

Publications for OTUD3 Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4 67
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3
  3. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. (PMID: 23511034) Yang S.K. … Song K. (Inflamm. Bowel Dis. 2013) 3
  4. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3
  5. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3

Products for OTUD3 Gene

Sources for OTUD3 Gene

Back to Top

Content