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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTUD1 Gene

protein-coding   GIFtS: 40
GCID: GC10P023768

OTU domain containing 1


(Previous symbol: OTDC1)
 Explore 1 disease affiliated with
OTUD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OTUD1    

Aliases
for OTUD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
OTU Domain Containing 11 2
DUBA71 2 3 5
OTDC11 2 3
DUBA-72 3
OTU Domain-Containing Protein 12

External Ids:    HGNC: 273461   Entrez Gene: 2202132   Ensembl: ENSG000001653127   OMIM: 6120225   UniProtKB: Q5VV173   

Export aliases for OTUD1 gene to outside databases

Previous GC identifers: GC10P023693 GC10P023389


Summaries
for OTUD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OTUD1:
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages,
negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU)
domain.(supplied by OMIM, May 2008)




Genomic Views
for OTUD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTUD1 gene promoter:
         TBP   HFH-3   C/EBPbeta   Elk-1   AP-4   CREB   FOXI1   S8   E2F-1   E2F   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OTUD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTUD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.2   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12.31

OTUD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P023768:  view genomic region     (about GC identifiers)

Start:
 23,728,198 bp from pter      End:
 23,731,310 bp from pter
Size:
 3,113 bases      Orientation:
 plus strand

Proteins
for OTUD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OTUD1_HUMAN, Q5VV17 (See protein sequence)
Recommended Name: OTU domain-containing protein 1  
Size: 481 amino acids; 51063 Da

Explore the universe of human proteins at neXtProt for OTUD1: NX_Q5VV17

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5VV17

    • OTUD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001138845.1  
    ENSEMBL proteins: 
     ENSP00000365678  

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    Protein Domains /
    Families
    for OTUD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OTUD1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q5VV17

    ProtoNet protein and cluster: Q5VV17

    1 Blocks protein family: IPB003323 OTU-like cysteine protease

    UniProtKB/Swiss-Prot: OTUD1_HUMAN, Q5VV17
    Similarity: Contains 1 OTU domain


    Function
    for OTUD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: OTUD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTUD1
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD1 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-548k hsa-miR-106a hsa-miR-29a hsa-miR-1244 hsa-miR-124
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for OTUD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTUD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for OTUD1 (Q5VV173 ENSP000003656784) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNBO753693, ENSP000002959564I2D: score=2 STRING: ENSP00000295956
    RAD23AP547253, ENSP000003213654I2D: score=2 STRING: ENSP00000321365
    FLNAP213333, ENSP000003588664I2D: score=2 STRING: ENSP00000358866
    FLNCQ143153, ENSP000003271454I2D: score=2 STRING: ENSP00000327145
    RAD23BP547273, ENSP000003507084I2D: score=2 STRING: ENSP00000350708
    About this table

    Drugs & Compounds
    for OTUD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTUD1
    Search CenterWatch for drugs/clinical trials and news about OTUD1 

    Transcripts
    for OTUD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OTUD1 gene: 
    NM_001145373.2  

    Unigene Cluster for OTUD1:

    OTU domain containing 1
    Hs.499042  [show with all ESTs]
    Unigene Representative Sequence: NM_001145373
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376495(uc001irr.2)

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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate OTUD1 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-548k hsa-miR-106a hsa-miR-29a hsa-miR-1244 hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OTUD1
    OriGene shRNA RFP: OTUD1
    OriGene siRNA: OTUD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTUD1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTUD1
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    GenScript: all cDNA clones in your preferred vector: OTUD1 (NM_001145373)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTUD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTUD1

    Additional cDNA sequence: 

    AB188491.1 AK096389.1 

    1 DOTS entry:

    DT.413213 

    24/89 AceView cDNA sequences (see all 89):

    BQ185502 CD368173 AA564858 CD365827 BQ002884 BQ187849 CD368529 BM668705 
    BQ632557 AA436058 BQ015766 BX501624 AA435960 BQ632845 AI675583 AA479209 
    AB188491 AI270121 AW673143 AW083367 BF845075 AW937884 CB132805 BM693428 

    GeneLoc Exon Structure


    Expression
    for OTUD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTUD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATAAAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OTUD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OTUD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTUD1

    SOURCE GeneReport for Unigene cluster: Hs.499042
        SABiosciences Custom PCR Arrays for OTUD1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTUD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD1

    Orthologs
    for OTUD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for OTUD1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Otud11 , 5 OTU domain containing 11, 5 82.62(n)1
    82.92(a)1    		   2 (13.78 cM)5
    711981  NM_027715.11  NP_081991.11 
     196577525 
    chicken
    (Gallus gallus)    		 Aves OTUD11 OTU domain containing 1 66.56(n)
    67.58(a)    		   420502  XM_418604.3  XP_418604.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.49712 Xenopus laevis transcribed sequence with moderate similarity more 77.93(n)    BU913593.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.171112 Transcribed sequences 71.87(n)    AL928099.1 


    ENSEMBL Gene Tree for OTUD1 (if available)
    TreeFam Gene Tree for OTUD1 (if available) 

    Paralogs
    for OTUD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTUD1 gene

    OTUD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OTUD1
    PGOHUM00000246451


    Genomic Variants
    for OTUD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/73 NCBI SNPs in OTUD1 are shown (see all 73)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1808963621,2
    		--23726208(+) GTCATG/TTACCT 1 -- us2k10--------
    rs1841455771,2
    		--23726211(+) ATTTAC/TCTTCT 1 -- us2k10--------
    rs70841451,2
    		C,F,H,--23726374(+) TTCCAT/CCTact 1 -- us2k110Minor allele frequency- C:0.14NS EA NA WA CSA 684
    rs70806481,2
    		C,F,A,H,--23726421(+) TGCCAA/GGCACG 1 -- us2k16Minor allele frequency- G:0.21EA NS WA CSA 410
    rs762385391,2
    		--23726446(+) AAATAT/CAAGAG 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs70971671,2
    		C,F,A,H,--23726492(+) TCCACC/TGGAAA 1 -- us2k1 tfbs320Minor allele frequency- T:0.24NS EA NA WA CSA 2342
    rs70971851,2
    		C,F,H,--23726526(+) CATCAC/TCTACA 1 -- us2k110Minor allele frequency- T:0.14NS EA NA WA CSA 684
    rs1900081731,2
    		--23726582(+) CAATTA/CGAATG 1 -- us2k10--------
    rs19959811,2
    		C,F,A,--23726776(-) AGGTGC/TGAATG 1 -- us2k17Minor allele frequency- T:0.50NA WA CSA EA 248
    rs1445055191,2
    		--23726815(+) ATTTGA/GTATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OTUD1 (23728198 - 23731310 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OTUD1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for OTUD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OTUD1 for disorders           About GeneDecksing

    OMIM gene information: 612022    OMIM disorders: --

    1 disease for OTUD1:    About MalaCards
    pneumonia


    Export disorders for OTUD1 gene to outside databases

    Publications
    for OTUD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTUD1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OTUD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    4. DUBA: a deubiquitinase that regulates type I interferon production. (PubMed id 17991829)1 Kayagaki N....Dixit V.M. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. (PubMed id 10664582)1 Makarova K.S....Koonin E.V. (2000)

    External Searches for OTUD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OTUD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220213 HGNC: 27346 AceView: OTUD1 Ensembl:ENSG00000165312 euGenes: HUgn220213
    ECgene: OTUD1 H-InvDB: OTUD1

    Other Databases showing OTUD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OTUD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTUD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OTUD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OTUD1 gene:
    Search GeneIP for patents involving OTUD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OTUD1 gene

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    Advanced Cell Diagnostics
    About This Section

     
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