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Aliases for OTUD1 Gene

Aliases for OTUD1 Gene

  • OTU Deubiquitinase 1 2 3 5
  • OTU Domain Containing 1 2 3
  • DUBA-7 3 4
  • OTDC1 3 4
  • DUBA7 3 4
  • EC 4

External Ids for OTUD1 Gene

Previous HGNC Symbols for OTUD1 Gene

  • OTDC1

Previous GeneCards Identifiers for OTUD1 Gene

  • GC10P023693
  • GC10P023768
  • GC10P023389
  • GC10P023728

Summaries for OTUD1 Gene

Entrez Gene Summary for OTUD1 Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD1 Gene

OTUD1 (OTU Deubiquitinase 1) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD1 Gene

  • Deubiquitinating enzyme that specifically hydrolyzes Lys-63-linked polyubiquitin to monoubiquitin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD1 Gene

Genomics for OTUD1 Gene

Regulatory Elements for OTUD1 Gene

Enhancers for OTUD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OTUD1 on UCSC Golden Path with GeneCards custom track

Promoters for OTUD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OTUD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OTUD1 Gene

23,439,269 bp from pter
23,442,390 bp from pter
3,122 bases
Plus strand

Genomic View for OTUD1 Gene

Genes around OTUD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD1 Gene

Proteins for OTUD1 Gene

  • Protein details for OTUD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 1
    Protein Accession:

    Protein attributes for OTUD1 Gene

    481 amino acids
    Molecular mass:
    51063 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OTUD1 Gene

neXtProt entry for OTUD1 Gene

Proteomics data for OTUD1 Gene at MOPED

Post-translational modifications for OTUD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD1 Gene

Domains & Families for OTUD1 Gene

Gene Families for OTUD1 Gene

Protein Domains for OTUD1 Gene


Suggested Antigen Peptide Sequences for OTUD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UIM repeat increases the specificity and efficiency of the enzyme toward Lys-63-linked polyubiquitin.
  • The UIM repeat increases the specificity and efficiency of the enzyme toward Lys-63-linked polyubiquitin.
  • Specificity is not given by the S1 ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).
  • Contains 1 OTU domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
genes like me logo Genes that share domains with OTUD1: view

Function for OTUD1 Gene

Molecular function for OTUD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that specifically hydrolyzes Lys-63-linked polyubiquitin to monoubiquitin.

Enzyme Numbers (IUBMB) for OTUD1 Gene

genes like me logo Genes that share phenotypes with OTUD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OTUD1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD1 Gene

Localization for OTUD1 Gene

Subcellular locations from

Jensen Localization Image for OTUD1 Gene COMPARTMENTS Subcellular localization image for OTUD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD1 Gene

Pathways & Interactions for OTUD1 Gene

SuperPathways for OTUD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OTUD1 Gene

Drugs & Compounds for OTUD1 Gene

No Compound Related Data Available

Transcripts for OTUD1 Gene

mRNA/cDNA for OTUD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD1 Gene

OTU domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD1 Gene

No ASD Table

Relevant External Links for OTUD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD1 Gene

mRNA expression in normal human tissues for OTUD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OTUD1 Gene

This gene is overexpressed in Plasma (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OTUD1 Gene

SOURCE GeneReport for Unigene cluster for OTUD1 Gene Hs.499042

genes like me logo Genes that share expression patterns with OTUD1: view

Protein tissue co-expression partners for OTUD1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD1 Gene

Orthologs for OTUD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTUD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OTUD1 35
  • 86.47 (n)
  • 87.87 (a)
OTUD1 36
  • 90 (a)
(Mus musculus)
Mammalia Otud1 35
  • 81.95 (n)
  • 82.25 (a)
Otud1 16
Otud1 36
  • 81 (a)
(Pan troglodytes)
Mammalia OTUD1 35
  • 99.37 (n)
  • 99.58 (a)
OTUD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Otud1 35
  • 81.17 (n)
  • 82.06 (a)
(Canis familiaris)
Mammalia OTUD1 36
  • 90 (a)
(Monodelphis domestica)
Mammalia OTUD1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia OTUD1 36
  • 74 (a)
(Gallus gallus)
Aves OTUD1 35
  • 73.33 (n)
  • 77.65 (a)
OTUD1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia OTUD1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10971 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4971 35
(Danio rerio)
Actinopterygii Dr.17111 35
Species with no ortholog for OTUD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD1 Gene

Gene Tree for OTUD1 (if available)
Gene Tree for OTUD1 (if available)

Paralogs for OTUD1 Gene Pseudogenes for OTUD1 Gene

genes like me logo Genes that share paralogs with OTUD1: view

No data available for Paralogs for OTUD1 Gene

Variants for OTUD1 Gene

Sequence variations from dbSNP and Humsavar for OTUD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1511822 -- 23,440,594(+) TACCC(A/C/G)GAGTT reference, synonymous-codon
rs1995981 -- 23,437,847(-) AGGTG(C/T)GAATG upstream-variant-2KB
rs7093562 -- 23,439,253(+) CCCCC(C/T)GCGCT upstream-variant-2KB
rs7097167 -- 23,437,563(+) TCCAC(C/T)GGAAA upstream-variant-2KB
rs7097185 -- 23,437,597(+) CATCA(C/T)CTACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTUD1 Gene

Variant ID Type Subtype PubMed ID
nsv825305 CNV Gain 20364138

Variation tolerance for OTUD1 Gene

Gene Damage Index Score: 1.70; 32.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OTUD1 Gene

Disorders for OTUD1 Gene

Relevant External Links for OTUD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OTUD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD1 Gene

Publications for OTUD1 Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4 67
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  3. A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours. (PMID: 24937664) Carneiro A.P. … Ward L.S. (Br. J. Cancer 2014) 3
  4. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (PMID: 23563609) Wheeler E. … Farooqi I.S. (Nat. Genet. 2013) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for OTUD1 Gene

Sources for OTUD1 Gene