Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OTUD1 Gene

Aliases for OTUD1 Gene

  • OTU Deubiquitinase 1 2 3 5
  • OTU Domain Containing 1 2 3
  • DUBA-7 3 4
  • OTDC1 3 4
  • DUBA7 3 4
  • OTU Domain-Containing Protein 1 3
  • EC 3.4.19.12 4

External Ids for OTUD1 Gene

Previous HGNC Symbols for OTUD1 Gene

  • OTDC1

Previous GeneCards Identifiers for OTUD1 Gene

  • GC10P023693
  • GC10P023768
  • GC10P023389
  • GC10P023728

Summaries for OTUD1 Gene

Entrez Gene Summary for OTUD1 Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD1 Gene

OTUD1 (OTU Deubiquitinase 1) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for OTUD1 Gene

  • Deubiquitinating enzyme that specifically hydrolyzes Lys-63-linked polyubiquitin to monoubiquitin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD1 Gene

Genomics for OTUD1 Gene

Regulatory Elements for OTUD1 Gene

Enhancers for OTUD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F023511 1.5 FANTOM5 Ensembl ENCODE 18.4 +73.3 73346 1.6 TBP HDAC1 PKNOX1 ATF1 NFRKB RCOR1 FOS CREM THAP11 CEBPB OTUD1 C10orf67 LOC105376453 KIAA1217 GC10M023494 GC10P023457
GH10F023412 1.4 FANTOM5 Ensembl ENCODE 15.4 -26.7 -26736 0.9 KLF1 JUN INSM2 ZEB1 RFX5 ZNF366 FOS KLF8 ZNF639 CEBPB C10orf67 OTUD1 LOC105376453 ENSG00000227537 MIR1254-2
GH10F023431 1.2 FANTOM5 Ensembl ENCODE 16.5 -6.5 -6539 1.8 KLF1 ZNF146 CEBPB STAT3 OTUD1 C10orf67 LOC105376453 MIR1254-2
GH10F023448 1.3 FANTOM5 Ensembl ENCODE 15 +11.0 11032 4.2 JUN ZNF175 ZNF121 ZNF316 ZNF366 ETV6 MAFK CREM MAFG CEBPB OTUD1 C10orf67 LOC105376453 GC10P023441 GC10P023457
GH10F023413 1.4 FANTOM5 Ensembl ENCODE 13.6 -25.6 -25569 1.4 CTCF PKNOX1 ZNF76 SIN3A RAD21 ZBTB48 CBX5 SMC3 PRDM10 CREM OTUD1 C10orf67 LOC105376453 MIR1254-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUD1 on UCSC Golden Path with GeneCards custom track

Promoters for OTUD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001421784 1231 4201 ATF1 CREB3L1 ARID4B SIN3A GLIS2 ZNF263 SP3 SP5 MXD4 REST

Genomic Location for OTUD1 Gene

Chromosome:
10
Start:
23,439,269 bp from pter
End:
23,442,390 bp from pter
Size:
3,122 bases
Orientation:
Plus strand

Genomic View for OTUD1 Gene

Genes around OTUD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD1 Gene

Proteins for OTUD1 Gene

  • Protein details for OTUD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV17-OTUD1_HUMAN
    Recommended name:
    OTU domain-containing protein 1
    Protein Accession:
    Q5VV17

    Protein attributes for OTUD1 Gene

    Size:
    481 amino acids
    Molecular mass:
    51063 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OTUD1 Gene

neXtProt entry for OTUD1 Gene

Post-translational modifications for OTUD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTUD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD1 Gene

Domains & Families for OTUD1 Gene

Gene Families for OTUD1 Gene

Protein Domains for OTUD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VV17

UniProtKB/Swiss-Prot:

OTUD1_HUMAN :
  • The UIM repeat increases the specificity and efficiency of the enzyme toward Lys-63-linked polyubiquitin.
Domain:
  • The UIM repeat increases the specificity and efficiency of the enzyme toward Lys-63-linked polyubiquitin.
  • Specificity is not given by the S1 ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).
  • Contains 1 OTU domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
genes like me logo Genes that share domains with OTUD1: view

Function for OTUD1 Gene

Molecular function for OTUD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that specifically hydrolyzes Lys-63-linked polyubiquitin to monoubiquitin.

Enzyme Numbers (IUBMB) for OTUD1 Gene

Gene Ontology (GO) - Molecular Function for OTUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 23827681
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD1: view
genes like me logo Genes that share phenotypes with OTUD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OTUD1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OTUD1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD1 Gene

Localization for OTUD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OTUD1 Gene

Pathways & Interactions for OTUD1 Gene

SuperPathways for OTUD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0070536 protein K63-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD1: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD1 Gene

Transcripts for OTUD1 Gene

mRNA/cDNA for OTUD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD1 Gene

OTU domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OTUD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD1 Gene

No ASD Table

Relevant External Links for OTUD1 Gene

GeneLoc Exon Structure for
OTUD1
ECgene alternative splicing isoforms for
OTUD1

Expression for OTUD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OTUD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OTUD1 Gene

This gene is overexpressed in Plasma (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OTUD1 Gene



Protein tissue co-expression partners for OTUD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OTUD1 Gene:

OTUD1

SOURCE GeneReport for Unigene cluster for OTUD1 Gene:

Hs.499042
genes like me logo Genes that share expression patterns with OTUD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OTUD1 Gene

Orthologs for OTUD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTUD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD1 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia OTUD1 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTUD1 34 35
  • 86.47 (n)
mouse
(Mus musculus)
Mammalia Otud1 34 16 35
  • 81.95 (n)
rat
(Rattus norvegicus)
Mammalia Otud1 34
  • 81.17 (n)
oppossum
(Monodelphis domestica)
Mammalia OTUD1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTUD1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTUD1 34 35
  • 73.33 (n)
lizard
(Anolis carolinensis)
Reptilia OTUD1 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10971 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4971 34
zebrafish
(Danio rerio)
Actinopterygii Dr.17111 34
Species where no ortholog for OTUD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD1 Gene

ENSEMBL:
Gene Tree for OTUD1 (if available)
TreeFam:
Gene Tree for OTUD1 (if available)

Paralogs for OTUD1 Gene

Pseudogenes.org Pseudogenes for OTUD1 Gene

genes like me logo Genes that share paralogs with OTUD1: view

No data available for Paralogs for OTUD1 Gene

Variants for OTUD1 Gene

Sequence variations from dbSNP and Humsavar for OTUD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11013488 -- 23,438,246(+) AAGAC(C/G)CGGCG upstream-variant-2KB
rs11013489 -- 23,438,284(+) AATCC(C/T)AACAC upstream-variant-2KB
rs11013490 -- 23,438,302(+) GGTCG(A/G)GGCGG upstream-variant-2KB
rs112111625 -- 23,439,095(+) GCTCC(G/T)CCTCG upstream-variant-2KB
rs112344790 -- 23,439,494(+) ACCCC(A/G)CCGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OTUD1 Gene

Variant ID Type Subtype PubMed ID
esv3432719 CNV insertion 20981092
nsv1068294 CNV deletion 25765185
nsv1136113 CNV deletion 24896259
nsv825305 CNV gain 20364138

Variation tolerance for OTUD1 Gene

Gene Damage Index Score: 1.70; 32.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD1 Gene

Disorders for OTUD1 Gene

Relevant External Links for OTUD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUD1

No disorders were found for OTUD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD1 Gene

Publications for OTUD1 Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours. (PMID: 24937664) Carneiro A.P. … Ward L.S. (Br. J. Cancer 2014) 3 64
  5. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (PMID: 23563609) Wheeler E. … Farooqi I.S. (Nat. Genet. 2013) 3 64

Products for OTUD1 Gene

Sources for OTUD1 Gene

Content
Loading form....