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OTUD1 Gene

protein-coding   GIFtS: 43
GCID: GC10P023728

OTU Deubiquitinase 1

(Previous name: OTU domain containing 1)
(Previous symbol: OTDC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase 11 2     DUBA-72 3
OTDC11 2 3     OTU Domain-Containing Protein 12
DUBA72 3 5     EC 3.4.19.123
OTU Domain Containing 11 2     

External Ids:    HGNC: 273461   Entrez Gene: 2202132   Ensembl: ENSG000001653127   OMIM: 6120225   UniProtKB: Q5VV173   

Export aliases for OTUD1 gene to outside databases

Previous GC identifers: GC10P023693 GC10P023768 GC10P023389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTUD1 Gene:
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339)
linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian
tumor (OTU) domain.(supplied by OMIM, May 2008)

GeneCards Summary for OTUD1 Gene:
OTUD1 (OTU deubiquitinase 1) is a protein-coding gene. Diseases associated with OTUD1 include pneumonia, and pancreatitis. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot: OTUD1_HUMAN, Q5VV17
Function: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUD1 gene promoter:
         TBP   HFH-3   C/EBPbeta   Elk-1   AP-4   CREB   FOXI1   S8   E2F-1   E2F   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OTUD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.2   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12.31

OTUD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P023728:  view genomic region     (about GC identifiers)

Start:
23,728,198 bp from pter      End:
23,731,310 bp from pter
Size:
3,113 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OTUD1_HUMAN, Q5VV17 (See protein sequence)
Recommended Name: OTU domain-containing protein 1  
Size: 481 amino acids; 51063 Da
1 PDB 3D structure from and Proteopedia for OTUD1:
4BOP (3D)    

Explore the universe of human proteins at neXtProt for OTUD1: NX_Q5VV17

Explore proteomics data for OTUD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OTUD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138845.1  
    ENSEMBL proteins: 
     ENSP00000365678  

    OTUD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for OTUD1
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    Cloud-Clone Corp. Proteins for OTUD1

    OTUD1 Antibody Products:

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    Abcam antibodies for OTUD1
    Cloud-Clone Corp. Antibodies for OTUD1
    Search ThermoFisher Antibodies for OTUD1
    LSBio Antibodies in human, mouse, rat for OTUD1

    OTUD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for OTUD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OTUD1
    Cloud-Clone Corp. CLIAs for OTUD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    1 InterPro protein domain:
     IPR003323 OTU

    Graphical View of Domain Structure for InterPro Entry Q5VV17

    ProtoNet protein and cluster: Q5VV17

    1 Blocks protein domain: IPB003323 OTU-like cysteine protease

    UniProtKB/Swiss-Prot: OTUD1_HUMAN, Q5VV17
    Domain: The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin
    (PubMed:23827681)
    Domain: Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-,
    His- and Variable-loops) (PubMed:23827681)
    Similarity: Contains 1 OTU domain
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat


    OTUD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUD1_HUMAN, Q5VV17
    Function: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
         
    OTUD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUD1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTUD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTUD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OTUD1:
    hsa-mir-181a-5p (MIRT025128), hsa-mir-335-5p (MIRT019208), hsa-mir-192-5p (MIRT026901), hsa-mir-320a (MIRT044547), hsa-mir-340-5p (MIRT019636), hsa-mir-21-5p (MIRT050474), hsa-mir-421 (MIRT039378), hsa-mir-19b-3p (MIRT031292)

    Block miRNA regulation of human, mouse, rat OTUD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD1 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-548k hsa-miR-106a hsa-miR-29a hsa-miR-1244 hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OTUD1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for OTUD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTUD1 (NM_001145373)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OTUD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OTUD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUD1
    Interactions:

        Search GeneGlobe Interaction Network for OTUD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OTUD1 (Q5VV173 ENSP000003656784) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNBO753693, ENSP000002959564I2D: score=2 STRING: ENSP00000295956
    RAD23AP547253, ENSP000003213654I2D: score=2 STRING: ENSP00000321365
    FLNAP213333, ENSP000003588664I2D: score=2 STRING: ENSP00000358866
    FLNCQ143153, ENSP000003271454I2D: score=2 STRING: ENSP00000327145
    RAD23BP547273, ENSP000003507084I2D: score=2 STRING: ENSP00000350708
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0070536protein K63-linked deubiquitination IDA--

    OTUD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OTUD1 gene: 
    NM_001145373.2  

    Unigene Cluster for OTUD1:

    OTU domain containing 1
    Hs.499042  [show with all ESTs]
    Unigene Representative Sequence: NM_001145373
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376495(uc001irr.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OTUD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUD1 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-548k hsa-miR-106a hsa-miR-29a hsa-miR-1244 hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OTUD1
    Predesigned siRNA for gene silencing in human, mouse, rat OTUD1
    Clone
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    OriGene clones in human, mouse for OTUD1 (see all 6)
    OriGene ORF clones in mouse, rat for OTUD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTUD1 (NM_001145373)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUD1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OTUD1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OTUD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OTUD1
      QuantiTect SYBR Green Assays in human, mouse, rat OTUD1
      QuantiFast Probe-based Assays in human, mouse, rat OTUD1

    Additional mRNA sequence: 

    AB188491.1 AK096389.1 

    1 DOTS entry:

    DT.413213 

    Selected AceView cDNA sequences (see all 89):

    BQ185502 BQ632845 CD368173 AA564858 CD365827 AA435960 BX501624 BM668705 
    BQ632557 BQ002884 AA436058 BQ015766 CD368529 BQ187849 BG614004 BF175985 
    AI718142 BF845075 AA479209 AB188491 AI719802 AI675583 AW673143 AW083367 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUD1 expression in normal human tissues (normalized intensities)      OTUD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATAAAACT
    OTUD1 Expression
    About this image


    OTUD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
    OTUD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499042
        Custom PCR Arrays for OTUD1
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    OriGene qSTAR qPCR primer pairs in human, mouse for OTUD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OTUD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OTUD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otud11 , 5 OTU domain containing 11, 5 81.95(n)1
    82.25(a)1
      2 (13.78 cM)5
    711981  NM_027715.11  NP_081991.11 
     196577525 
    chicken
    (Gallus gallus)
    Aves OTUD11 OTU domain containing 1 73.33(n)
    77.65(a)
      420502  XM_418604.4  XP_418604.4 
    lizard
    (Anolis carolinensis)
    Reptilia OTUD16
    OTU domain containing 1
    51(a)
    1 ↔ 1
    6(15869556-15872048)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.49712 Xenopus laevis transcribed sequence with moderate similarity more 77.93(n)    BU913593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171112 Transcribed sequences 71.87(n)    AL928099.1 


    ENSEMBL Gene Tree for OTUD1 (if available)
    TreeFam Gene Tree for OTUD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTUD1 gene

    OTUD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OTUD1
    PGOHUM00000246451


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUD1 (see all 86)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808963621,2
    --23726208(+) GTCATG/TTACCT 1 -- us2k10--------
    rs1841455771,2
    --23726211(+) ATTTAC/TCTTCT 1 -- us2k10--------
    rs70841451,2
    C,F,H--23726374(+) TTCCAT/CCTact 1 -- us2k110Minor allele frequency- C:0.14NS EA NA WA CSA 684
    rs70806481,2
    C,F,A,H--23726421(+) TGCCAA/GGCACG 1 -- us2k16Minor allele frequency- G:0.21EA NS WA CSA 410
    rs762385391,2
    C,F--23726446(+) AAATAT/CAAGAG 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs70971671,2
    C,F,A,H--23726492(+) TCCACC/TGGAAA 1 -- us2k1 tfbs320Minor allele frequency- T:0.24NS EA NA WA CSA 2342
    rs70971851,2
    C,F,H--23726526(+) CATCAC/TCTACA 1 -- us2k110Minor allele frequency- T:0.14NS EA NA WA CSA 684
    rs1900081731,2
    --23726582(+) CAATTA/CGAATG 1 -- us2k10--------
    rs19959811,2
    C,F,A--23726776(-) AGGTGC/TGAATG 1 -- us2k17Minor allele frequency- T:0.50NA WA CSA EA 248
    rs1445055191,2
    --23726815(+) ATTTGA/GTATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OTUD1 (23728198 - 23731310 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OTUD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825305CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUD1
    DNA2.0 Custom Variant and Variant Library Synthesis for OTUD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612022    OMIM disorders: --

    2 diseases for OTUD1:    About MalaCards
    pneumonia    pancreatitis


    OTUD1 for disorders           About GeneDecksing


    Export disorders for OTUD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUD1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OTUD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)1, 2, 3 Mevissen T.E.... Komander D. (Cell 2013)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    3. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (PubMed id 23563609)1 Wheeler E....Farooqi I.S. (Nat. Genet. 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    7. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    8. DUBA: a deubiquitinase that regulates type I interferon production. (PubMed id 17991829)1 Kayagaki N....Dixit V.M. (Science 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. (PubMed id 10664582)1 Makarova K.S....Koonin E.V. (Trends Biochem. Sci. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220213 HGNC: 27346 AceView: OTUD1 Ensembl:ENSG00000165312 euGenes: HUgn220213
    ECgene: OTUD1 H-InvDB: OTUD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUD1 gene:
    Search GeneIP for patents involving OTUD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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