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Aliases for OTUB2 Gene

Aliases for OTUB2 Gene

  • OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2 2 3
  • C14orf137 3 4 6
  • OTB2 3 4 6
  • OTU2 3 4 6
  • OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 2 3 4
  • Ubiquitin-Specific-Processing Protease OTUB2 3 4
  • OTU Domain, Ubiquitin Aldehyde Binding 2 2 3
  • Deubiquitinating Enzyme OTUB2 3 4
  • Otubain-2 3 4
  • Ubiquitin-Specific Protease Otubain 2 3
  • Chromosome 14 Open Reading Frame 137 2
  • Ubiquitin Thioesterase OTUB2 3
  • EC 4

External Ids for OTUB2 Gene

Previous Symbols for OTUB2 Gene

  • C14orf137

Summaries for OTUB2 Gene

Entrez Gene Summary for OTUB2 Gene

  • This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

GeneCards Summary for OTUB2 Gene

OTUB2 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and omega peptidase activity. An important paralog of this gene is OTUB1.

UniProtKB/Swiss-Prot for OTUB2 Gene

  • Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of Lys-11-,Lys-48- and Lys-63-linked polyubiquitin chains, with a preference for Lys-63-linked polyubiquitin chains.

Gene Wiki entry for OTUB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUB2 Gene

Genomics for OTUB2 Gene

Genomic Location for OTUB2 Gene

94,023,165 bp from pter
94,048,930 bp from pter
25,766 bases
Plus strand

Genomic View for OTUB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUB2 Gene

Regulatory Elements for OTUB2 Gene

Proteins for OTUB2 Gene

  • Protein details for OTUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin thioesterase OTUB2
    Protein Accession:
    Secondary Accessions:
    • Q6IA10
    • Q9H6T1

    Protein attributes for OTUB2 Gene

    234 amino acids
    Molecular mass:
    27213 Da
    Quaternary structure:
    No Data Available
    • In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of His-224 in presence of ubiquitin substrate

    Three dimensional structures from OCA and Proteopedia for OTUB2 Gene

    Alternative splice isoforms for OTUB2 Gene


neXtProt entry for OTUB2 Gene

Proteomics data for OTUB2 Gene at MOPED

Post-translational modifications for OTUB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94

Other Protein References for OTUB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUB2 Gene

Domains for OTUB2 Gene

Gene Families for OTUB2 Gene

  • OTUD :OTU domain containing

Protein Domains for OTUB2 Gene


  • Contains 1 OTU domain.:
    • Q96DC9
  • Belongs to the peptidase C65 family.:
    • Q96DC9
genes like me logo Genes that share domains with OTUB2: view

Function for OTUB2 Gene

Molecular function for OTUB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of Lys-11-,Lys-48- and Lys-63-linked polyubiquitin chains, with a preference for Lys-63-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for OTUB2 Gene

Gene Ontology (GO) - Molecular Function for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IMP 15258613
GO:0005515 protein binding IPI 25416956
GO:0008242 omega peptidase activity --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with OTUB2: view

Phenotypes for OTUB2 Gene

genes like me logo Genes that share phenotypes with OTUB2: view

miRNA for OTUB2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for OTUB2 Gene

Localization for OTUB2 Gene

Subcellular locations from

Jensen Localization Image for OTUB2 Gene COMPARTMENTS Subcellular localization image for OTUB2 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with OTUB2: view

Pathways for OTUB2 Gene

SuperPathways for OTUB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006520 cellular amino acid metabolic process --
GO:0016579 protein deubiquitination IMP 15258613
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:0070536 protein K63-linked deubiquitination IDA 18954305
genes like me logo Genes that share ontologies with OTUB2: view

No data available for Pathways by source for OTUB2 Gene

Transcripts for OTUB2 Gene

Unigene Clusters for OTUB2 Gene

OTU domain, ubiquitin aldehyde binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTUB2 Gene

No ASD Table

Relevant External Links for OTUB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUB2 Gene

mRNA expression in normal human tissues for OTUB2 Gene

mRNA differential expression in normal tissues according to GTEx for OTUB2 Gene

This gene is overexpressed in Testis (10.3), Skin - Sun Exposed (Lower leg) (6.9), and Skin - Not Sun Exposed (Suprapubic) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OTUB2 Gene

SOURCE GeneReport for Unigene cluster for OTUB2 Gene Hs.278815

mRNA Expression by UniProt/SwissProt for OTUB2 Gene

Tissue specificity: Widely expressed. Expressed at higher level in brain.
genes like me logo Genes that share expressions with OTUB2: view

Orthologs for OTUB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OTUB2 36
  • 99.57 (n)
  • 99.57 (a)
OTUB2 37
  • 100 (a)
(Bos Taurus)
Mammalia OTUB2 36
  • 91.31 (n)
  • 95.3 (a)
OTUB2 37
  • 96 (a)
(Canis familiaris)
Mammalia OTUB2 36
  • 92.99 (n)
  • 95.71 (a)
OTUB2 37
  • 95 (a)
(Mus musculus)
Mammalia Otub2 36
  • 91.7 (n)
  • 94.85 (a)
Otub2 16
Otub2 37
  • 68 (a)
(Monodelphis domestica)
Mammalia OTUB2 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia OTUB2 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Otub2 36
  • 90.46 (n)
  • 94.87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otub2 36
  • 59.73 (n)
  • 51.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4968 37
  • 32 (a)
(Caenorhabditis elegans)
Secernentea otub-1 37
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5787 37
  • 31 (a)
Species with no ortholog for OTUB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for OTUB2 Gene

Gene Tree for OTUB2 (if available)
Gene Tree for OTUB2 (if available)

Paralogs for OTUB2 Gene

Paralogs for OTUB2 Gene

Selected SIMAP similar genes for OTUB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OTUB2: view

Variants for OTUB2 Gene

Sequence variations from dbSNP and Humsavar for OTUB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1112 -- 94,048,769(-) TGTTT(G/T)GCTCC utr-variant-3-prime
rs1113 -- 94,048,768(-) GTTTG(C/G)CTCCT utr-variant-3-prime
rs1114 -- 94,048,804(-) CCTCC(C/T)CACTC utr-variant-3-prime
rs877339 -- 94,022,346(+) AAAAA(C/T)GAACT upstream-variant-2KB
rs879981 -- 94,027,563(-) ATCAT(A/C)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTUB2 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV Loss 18971310

Relevant External Links for OTUB2 Gene

HapMap Linkage Disequilibrium report

Disorders for OTUB2 Gene

No disorders were found for OTUB2 Gene.

No data available for UniProtKB/Swiss-Prot for OTUB2 Gene

Publications for OTUB2 Gene

  1. Otubains: a new family of cysteine proteases in the ubiquitin pathway. (PMID: 12704427) Balakirev M.Y. … Chroboczek J. (EMBO Rep. 2003) 2 3 4 23
  2. Crystal structure of human otubain 2. (PMID: 15258613) Nanao M.H. … Balakirev M.Y. (EMBO Rep. 2004) 3 4 23
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OTUB2 Gene

Sources for OTUB2 Gene

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