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OTUB2 Gene

protein-coding   GIFtS: 50
GCID: GC14P094492

OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2

(Previous names: chromosome 14 open reading frame 137, OTU domain, ubiquitin...)
(Previous symbol: C14orf137)
  Search for OTUB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OTU Deubiquitinase, Ubiquitin Aldehyde Binding 21 2     OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 22 3
C14orf1371 2 3 5     Chromosome 14 Open Reading Frame 1371
OTB22 3 5     otubain-22
OTU22 3 5     Ubiquitin Thioesterase OTUB22
OTU Domain, Ubiquitin Aldehyde Binding 21 2     Ubiquitin-Specific Protease Otubain 22
Deubiquitinating Enzyme OTUB22 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease OTUB22 3     Otubain-23

External Ids:    HGNC: 203511   Entrez Gene: 789902   Ensembl: ENSG000000897237   OMIM: 6083385   UniProtKB: Q96DC93   

Export aliases for OTUB2 gene to outside databases

Previous GC identifers: GC14P092483 GC14P093562 GC14P074672


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTUB2 Gene:
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their
stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an
OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.
(provided by RefSeq, Aug 2011)

GeneCards Summary for OTUB2 Gene:
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and omega peptidase activity. An important paralog of this gene is OTUB1.

UniProtKB/Swiss-Prot: OTUB2_HUMAN, Q96DC9
Function: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an
important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination
of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for OTUB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NT_187601.1  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTUB2 gene promoter:
         LHX3b/Lhx3b   p53   ATF-2   POU6F1 (c2)   POU2F1   POU2F1a   HNF-1   LHX3a/Lhx3a   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTUB2 promoter sequence
   Search Chromatin IP Primers for OTUB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTUB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.13-q32.2

OTUB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTUB2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P094492:  view genomic region     (about GC identifiers)

Start:
94,492,675 bp from pter      End:
94,515,276 bp from pter
Size:
22,602 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTUB2_HUMAN, Q96DC9 (See protein sequence)
Recommended Name: Ubiquitin thioesterase OTUB2  
Size: 234 amino acids; 27213 Da
Miscellaneous: In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is
located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in
inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of
His-224 in presence of ubiquitin substrate
2 PDB 3D structures from and Proteopedia for OTUB2:
1TFF (3D)        4FJV (3D)    
Secondary accessions: Q6IA10 Q9H6T1
Alternative splicing: 2 isoforms:  Q96DC9-1   Q96DC9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTUB2: NX_Q96DC9

Explore proteomics data for OTUB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys94
  • Modification sites at PhosphoSitePlus

  • See OTUB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075601.1  
    ENSEMBL proteins: 
     ENSP00000203664   ENSP00000451283  

    OTUB2 Human Recombinant Protein Products:

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    Novus Biologicals OTUB2 Proteins
    Novus Biologicals OTUB2 Lysates
    Sino Biological Recombinant Protein for OTUB2
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    Cloud-Clone Corp. Proteins for OTUB2

    OTUB2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for OTUB2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing

    3 InterPro protein domains:
     IPR003323 OTU
     IPR016615 Ubiquitin_thioesterase_Otubain
     IPR019400 Peptidase_C65_otubain

    Graphical View of Domain Structure for InterPro Entry Q96DC9

    ProtoNet protein and cluster: Q96DC9

    UniProtKB/Swiss-Prot: OTUB2_HUMAN, Q96DC9
    Similarity: Belongs to the peptidase C65 family
    Similarity: Contains 1 OTU domain


    OTUB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUB2_HUMAN, Q96DC9
    Function: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an
    important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination
    of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked
    polyubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IMP15258613
    GO:0008242omega peptidase activity IEA--
         
    OTUB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Otub2):
     hematopoietic system  immune system 

    OTUB2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTUB2
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    miRNA
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    miRTarBase miRNAs that target OTUB2:
    hsa-mir-125a-5p (MIRT045773), hsa-mir-215-5p (MIRT024538), hsa-mir-192-5p (MIRT026192), hsa-mir-335-5p (MIRT016886)

    Block miRNA regulation of human, mouse, rat OTUB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUB2 (see all 42):
    hsa-let-7d hsa-miR-1224-3p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-let-7g hsa-miR-149 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTUB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUB2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTUB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    OTUB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTUB2
    Interactions:

        Search GeneGlobe Interaction Network for OTUB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for OTUB2 (Q96DC93 ENSP000002036644) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542523, ENSP000003523244I2D: score=2 STRING: ENSP00000352324
    GTF2IP783473, ENSP000003225424I2D: score=2 STRING: ENSP00000322542
    MAVSQ7Z4343, ENSP000004019804I2D: score=1 STRING: ENSP00000401980
    UBE2NP610883, ENSP000003161764I2D: score=1 STRING: ENSP00000316176
    TRAF3Q131143, ENSP000003324684I2D: score=1 STRING: ENSP00000332468
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006520cellular amino acid metabolic process IDA12704427
    GO:0016579protein deubiquitination IMP15258613
    GO:0019538protein metabolic process ----
    GO:0035871protein K11-linked deubiquitination IDA--

    OTUB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTUB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OTUB2 gene: 
    NM_023112.3  

    Unigene Cluster for OTUB2:

    OTU domain, ubiquitin aldehyde binding 2
    Hs.278815  [show with all ESTs]
    Unigene Representative Sequence: AK025569
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000203664(uc001yci.3) ENST00000553723(uc001ych.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat OTUB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OTUB2 (see all 42):
    hsa-let-7d hsa-miR-1224-3p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-let-7g hsa-miR-149 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTUB2
    Primer
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    OriGene qPCR primer pairs and template standards for OTUB2
    OriGene qSTAR qPCR primer pairs in human, mouse for OTUB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTUB2
      QuantiTect SYBR Green Assays in human, mouse, rat OTUB2
      QuantiFast Probe-based Assays in human, mouse, rat OTUB2

    Additional mRNA sequence: 

    AF318378.1 AK025569.1 AY177201.1 BC000208.1 BC009615.1 BC068058.1 CR457345.1 

    5 DOTS entries:

    DT.310192  DT.91664155  DT.100746766  DT.92045917  DT.95262713 

    Selected AceView cDNA sequences (see all 70):

    CA309811 BC000208 NM_023112 AA402461 BM667366 BM710646 BM750394 BC009615 
    BF223906 AF318378 AI401121 AI948840 BG395468 Z43435 AI200707 AI701714 
    AA723655 BE887089 BE255908 BG747995 AI018242 AA398564 F06546 BG750072 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTUB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGATGTAT
    OTUB2 Expression
    About this image

    OTUB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTUB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278815

    UniProtKB/Swiss-Prot: OTUB2_HUMAN, Q96DC9
    Tissue specificity: Widely expressed. Expressed at higher level in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OTUB2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otub21 , 5 OTU domain, ubiquitin aldehyde binding 21, 5 91.7(n)1
    94.85(a)1
      12 (52.92 cM)5
    681491  NM_001177841.11  NP_001171312.11 
     1033886825 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia otub21 OTU domain, ubiquitin aldehyde binding 2 59.73(n)
    51.13(a)
      100124322  NM_001101812.1  NP_001095282.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49686
    --
    32(a)
    1 → many
    2L(10306922-10308045)
    worm
    (Caenorhabditis elegans)
    Secernentea otub-16
    Protein OTUB-1 (otub-1) mRNA, complete cds
    22(a)
    1 → many
    V(15066298-15067464) WBGene00007718


    ENSEMBL Gene Tree for OTUB2 (if available)
    TreeFam Gene Tree for OTUB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTUB2 gene
    OTUB12  
    2 SIMAP similar genes for OTUB2 using alignment to 3 protein entries:     OTUB2_HUMAN (see all proteins):
    OTUB1    DKFZp564E242

    OTUB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTUB2 (see all 585)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844944601,2
    C--94490732(+) ATGGGC/TGGCCC 1 -- us2k10--------
    rs2019944501,2
    --94490732(+) ATGGG-/CGGCCC 1 -- us2k10--------
    rs1144346871,2
    C--94490733(+) TGGGCA/GGCCCC 1 -- us2k10--------
    rs1399580351,2
    --94490845(+) GAATCC/TTGATT 1 -- us2k10--------
    rs101489741,2
    C,F--94490868(+) GAAATT/CACATT 1 -- us2k15Minor allele frequency- C:0.15NA WA CSA 126
    rs1436779491,2
    C--94490941(+) TGTGT-/TGGTGTG 1 -- us2k10--------
    rs1815706091,2
    --94490951(+) GTGTGG/TGTGTG 1 -- us2k10--------
    rs608428951,2
    C--94490959(+) TGTGT-/GT    
       
    /GTGT
    TTAAA
    1 -- us2k10--------
    rs611413551,2
    C,F--94491099(+) GCAGTG/AAGTGG 1 -- us2k14Minor allele frequency- A:0.13WA CSA 123
    rs1438944331,2
    --94491175(+) GGCTTA/GGTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OTUB2 (94492675 - 94515276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OTUB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34067CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTUB2
    DNA2.0 Custom Variant and Variant Library Synthesis for OTUB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608338    OMIM disorders: --


    OTUB2 for disorders           About GeneDecksing


    Export disorders for OTUB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTUB2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with OTUB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Otubains: a new family of cysteine proteases in the ubiquitin pathway. (PubMed id 12704427)1, 2, 3, 9 Balakirev M.Y.... Chroboczek J. (EMBO Rep. 2003)
    2. Crystal structure of human otubain 2. (PubMed id 15258613)1, 2, 9 Nanao M.H....Balakirev M.Y. (EMBO Rep. 2004)
    3. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PubMed id 19996094)1, 3 Li S.... Shu H.B. (J. Biol. Chem. 2010)
    4. Structural basis and specificity of human otubain 1-mediated deubiquitination. (PubMed id 18954305)1, 2 Edelmann M.J.... Kessler B.M. (Biochem. J. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)2 Mevissen T.E.... Komander D. (Cell 2013)
    10. Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. (PubMed id 23515685)1 Beck A....Zick Y. (Diabetologia 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 78990 HGNC: 20351 AceView: OTUB2 Ensembl:ENSG00000089723 euGenes: HUgn78990
    ECgene: OTUB2 H-InvDB: OTUB2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTUB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OTUB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTUB2 gene:
    Search GeneIP for patents involving OTUB2

    GeneCards and IP:
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