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Aliases for OTUB2 Gene

Aliases for OTUB2 Gene

  • OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2 2 3 5
  • OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 2 3 4
  • Ubiquitin-Specific-Processing Protease OTUB2 3 4
  • OTU Domain, Ubiquitin Aldehyde Binding 2 2 3
  • Deubiquitinating Enzyme OTUB2 3 4
  • Otubain-2 3 4
  • C14orf137 3 4
  • OTB2 3 4
  • OTU2 3 4
  • Ubiquitin-Specific Protease Otubain 2 3
  • Chromosome 14 Open Reading Frame 137 2
  • Ubiquitin Thioesterase OTUB2 3
  • EC 3.4.19.12 4

External Ids for OTUB2 Gene

Previous HGNC Symbols for OTUB2 Gene

  • C14orf137

Previous GeneCards Identifiers for OTUB2 Gene

  • GC14P092483
  • GC14P093562
  • GC14P094492
  • GC14P074672

Summaries for OTUB2 Gene

Entrez Gene Summary for OTUB2 Gene

  • This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

GeneCards Summary for OTUB2 Gene

OTUB2 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2) is a Protein Coding gene. Among its related pathways are Ovarian tumor domain proteases and Metabolism of proteins. GO annotations related to this gene include hydrolase activity and omega peptidase activity. An important paralog of this gene is OTUB1.

UniProtKB/Swiss-Prot for OTUB2 Gene

  • Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of Lys-11-,Lys-48- and Lys-63-linked polyubiquitin chains, with a preference for Lys-63-linked polyubiquitin chains.

Gene Wiki entry for OTUB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUB2 Gene

Genomics for OTUB2 Gene

Regulatory Elements for OTUB2 Gene

Enhancers for OTUB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F094025 1.3 Ensembl ENCODE 6.4 +11.9 11921 4.1 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF48 ZNF2 GLIS2 KLF7 ZNF548 DDX24 LINC00521 ASB2 IFI27L2 IFI27L1 IFI27 OTUB2 GC14M094050 GC14M094051
GH14F094097 0.6 ENCODE 10.2 +82.4 82415 1.0 SOX13 ZFHX2 HNF1A NFIA TCF7 NR2F6 ZNF652 ZBTB40 IFI27L1 IFI27L2 OTUB2 GC14P094102 PIR54711
GH14F093322 1 Ensembl ENCODE 5.1 -692.3 -692317 2.1 CTCF PKNOX1 BACH1 RAD21 ZNF316 SCRT2 NFE2 MAFK ZNF362 FOXA3 COX8C UNC79 OTUB2 UBR7 BTBD7 ENSG00000241499
GH14F093174 0.8 ENCODE 4.4 -842.0 -841985 0.2 HDAC1 ATF1 PKNOX1 SAP130 RFX5 ZFHX2 FOXK2 RFXANK NFE2 CREM OTUB2 MOAP1 ENSG00000258595
GH14F093239 0.5 ENCODE 4.5 -775.5 -775473 2.2 JUND POLR2A FOS BTBD7 FAM181A-AS1 OTUB2 RPL36AP4 RPL18AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OTUB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OTUB2 Gene

Chromosome:
14
Start:
94,016,095 bp from pter
End:
94,048,930 bp from pter
Size:
32,836 bases
Orientation:
Plus strand

Genomic View for OTUB2 Gene

Genes around OTUB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUB2 Gene

Proteins for OTUB2 Gene

  • Protein details for OTUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DC9-OTUB2_HUMAN
    Recommended name:
    Ubiquitin thioesterase OTUB2
    Protein Accession:
    Q96DC9
    Secondary Accessions:
    • Q6IA10
    • Q9H6T1

    Protein attributes for OTUB2 Gene

    Size:
    234 amino acids
    Molecular mass:
    27213 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of His-224 in presence of ubiquitin substrate.

    Three dimensional structures from OCA and Proteopedia for OTUB2 Gene

    Alternative splice isoforms for OTUB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUB2 Gene

Post-translational modifications for OTUB2 Gene

  • Ubiquitination at Lys 94
  • Modification sites at PhosphoSitePlus

Other Protein References for OTUB2 Gene

No data available for DME Specific Peptides for OTUB2 Gene

Domains & Families for OTUB2 Gene

Gene Families for OTUB2 Gene

Protein Domains for OTUB2 Gene

Suggested Antigen Peptide Sequences for OTUB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DC9

UniProtKB/Swiss-Prot:

OTUB2_HUMAN :
  • Contains 1 OTU domain.
  • Belongs to the peptidase C65 family.
Domain:
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C65 family.
genes like me logo Genes that share domains with OTUB2: view

Function for OTUB2 Gene

Molecular function for OTUB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of Lys-11-,Lys-48- and Lys-63-linked polyubiquitin chains, with a preference for Lys-63-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for OTUB2 Gene

Gene Ontology (GO) - Molecular Function for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP 15258613
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUB2: view
genes like me logo Genes that share phenotypes with OTUB2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUB2 Gene

Localization for OTUB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUB2 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with OTUB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUB2 Gene

Pathways & Interactions for OTUB2 Gene

genes like me logo Genes that share pathways with OTUB2: view

Pathways by source for OTUB2 Gene

Gene Ontology (GO) - Biological Process for OTUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination IMP 15258613
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:0070536 protein K63-linked deubiquitination IDA 18954305
GO:0071108 protein K48-linked deubiquitination IDA 18954305
genes like me logo Genes that share ontologies with OTUB2: view

No data available for SIGNOR curated interactions for OTUB2 Gene

Transcripts for OTUB2 Gene

mRNA/cDNA for OTUB2 Gene

Unigene Clusters for OTUB2 Gene

OTU domain, ubiquitin aldehyde binding 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUB2 Gene

No ASD Table

Relevant External Links for OTUB2 Gene

GeneLoc Exon Structure for
OTUB2
ECgene alternative splicing isoforms for
OTUB2

Expression for OTUB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OTUB2 Gene

mRNA differential expression in normal tissues according to GTEx for OTUB2 Gene

This gene is overexpressed in Testis (x10.3), Skin - Sun Exposed (Lower leg) (x6.9), and Skin - Not Sun Exposed (Suprapubic) (x5.5).

Protein differential expression in normal tissues from HIPED for OTUB2 Gene

This gene is overexpressed in Ovary (34.6) and Testis (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OTUB2 Gene



Protein tissue co-expression partners for OTUB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OTUB2 Gene:

OTUB2

SOURCE GeneReport for Unigene cluster for OTUB2 Gene:

Hs.278815

mRNA Expression by UniProt/SwissProt for OTUB2 Gene:

Q96DC9-OTUB2_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in brain.
genes like me logo Genes that share expression patterns with OTUB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OTUB2 Gene

Orthologs for OTUB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUB2 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia OTUB2 34 35
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Otub2 34 16 35
  • 91.7 (n)
cow
(Bos Taurus)
Mammalia OTUB2 34 35
  • 91.31 (n)
rat
(Rattus norvegicus)
Mammalia Otub2 34
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia OTUB2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTUB2 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otub2 34
  • 59.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4968 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea otub-1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5787 35
  • 31 (a)
OneToMany
Species where no ortholog for OTUB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for OTUB2 Gene

ENSEMBL:
Gene Tree for OTUB2 (if available)
TreeFam:
Gene Tree for OTUB2 (if available)

Paralogs for OTUB2 Gene

Paralogs for OTUB2 Gene

(2) SIMAP similar genes for OTUB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OTUB2: view

Variants for OTUB2 Gene

Sequence variations from dbSNP and Humsavar for OTUB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1012014 -- 94,031,685(-) AGAAA(A/G)CGCAA intron-variant
rs1012015 -- 94,031,681(-) AGCGC(A/G)AGGAC intron-variant
rs1012016 -- 94,031,622(-) CTACA(G/T)CTGTC intron-variant
rs10131610 -- 94,034,903(+) AGCTG(A/C)AAGGG intron-variant
rs10132006 -- 94,033,357(+) TTAAA(A/T)ATTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTUB2 Gene

Variant ID Type Subtype PubMed ID
nsv952233 CNV deletion 24416366
nsv565620 CNV loss 21841781
esv3635373 CNV gain 21293372
esv3581391 CNV loss 25503493
esv34067 CNV loss 18971310

Variation tolerance for OTUB2 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTUB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUB2 Gene

Disorders for OTUB2 Gene

Relevant External Links for OTUB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTUB2

No disorders were found for OTUB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUB2 Gene

Publications for OTUB2 Gene

  1. Otubains: a new family of cysteine proteases in the ubiquitin pathway. (PMID: 12704427) Balakirev M.Y. … Chroboczek J. (EMBO Rep. 2003) 2 3 4 22 64
  2. Crystal structure of human otubain 2. (PMID: 15258613) Nanao M.H. … Balakirev M.Y. (EMBO Rep. 2004) 3 4 22 64
  3. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 3 4 64
  4. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PMID: 19996094) Li S. … Shu H.B. (J. Biol. Chem. 2010) 2 3 64
  5. Structural basis and specificity of human otubain 1-mediated deubiquitination. (PMID: 18954305) Edelmann M.J. … Kessler B.M. (Biochem. J. 2009) 3 4 64

Products for OTUB2 Gene

Sources for OTUB2 Gene

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