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Aliases for OTP Gene

Aliases for OTP Gene

  • Orthopedia Homeobox 2 3 5
  • Orthopedia Homolog (Drosophila) 2

External Ids for OTP Gene

Previous GeneCards Identifiers for OTP Gene

  • GC05M075730
  • GC05M077158
  • GC05M076963
  • GC05M077008
  • GC05M076960
  • GC05M072131
  • GC05M076924

Summaries for OTP Gene

Entrez Gene Summary for OTP Gene

  • This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

GeneCards Summary for OTP Gene

OTP (Orthopedia Homeobox) is a Protein Coding gene. Diseases associated with OTP include skull base meningioma. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is PRRX2.

UniProtKB/Swiss-Prot for OTP Gene

  • Probably involved in the differentiation of hypothalamic neuroendocrine cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTP Gene

Genomics for OTP Gene

Regulatory Elements for OTP Gene

Enhancers for OTP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OTP on UCSC Golden Path with GeneCards custom track

Genomic Location for OTP Gene

Chromosome:
5
Start:
77,628,712 bp from pter
End:
77,639,688 bp from pter
Size:
10,977 bases
Orientation:
Minus strand

Genomic View for OTP Gene

Genes around OTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTP Gene

Proteins for OTP Gene

  • Protein details for OTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKR4-OTP_HUMAN
    Recommended name:
    Homeobox protein orthopedia
    Protein Accession:
    Q5XKR4

    Protein attributes for OTP Gene

    Size:
    325 amino acids
    Molecular mass:
    34159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTP Gene

Proteomics data for OTP Gene at MOPED

Post-translational modifications for OTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTP Gene

Domains & Families for OTP Gene

Gene Families for OTP Gene

Suggested Antigen Peptide Sequences for OTP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKR4

UniProtKB/Swiss-Prot:

OTP_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family. Bicoid subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family. Bicoid subfamily.
genes like me logo Genes that share domains with OTP: view

Function for OTP Gene

Molecular function for OTP Gene

GENATLAS Biochemistry:
orthopedia homolog gene,homeo domain gene,expressed in hypothalamus,amygdalia and brain
UniProtKB/Swiss-Prot Function:
Probably involved in the differentiation of hypothalamic neuroendocrine cells.
genes like me logo Genes that share phenotypes with OTP: view

Animal Models for OTP Gene

MGI Knock Outs for OTP:

Animal Model Products

miRNA for OTP Gene

miRTarBase miRNAs that target OTP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTP Gene

Localization for OTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTP Gene COMPARTMENTS Subcellular localization image for OTP gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for OTP Gene

Pathways & Interactions for OTP Gene

SuperPathways for OTP Gene

No Data Available

Interacting Proteins for OTP Gene

Gene Ontology (GO) - Biological Process for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0021979 hypothalamus cell differentiation IEA --
GO:0021985 neurohypophysis development IEA --
genes like me logo Genes that share ontologies with OTP: view

No data available for Pathways by source and SIGNOR curated interactions for OTP Gene

Drugs & Compounds for OTP Gene

No Compound Related Data Available

Transcripts for OTP Gene

mRNA/cDNA for OTP Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTP Gene

Orthopedia homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTP Gene

No ASD Table

Relevant External Links for OTP Gene

GeneLoc Exon Structure for
OTP
ECgene alternative splicing isoforms for
OTP

Expression for OTP Gene

mRNA expression in normal human tissues for OTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OTP Gene

This gene is overexpressed in Brain - Hypothalamus (x48.7).

Protein differential expression in normal tissues from HIPED for OTP Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OTP Gene



SOURCE GeneReport for Unigene cluster for OTP Gene Hs.202247

genes like me logo Genes that share expression patterns with OTP: view

Protein tissue co-expression partners for OTP Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for OTP Gene

Orthologs for OTP Gene

This gene was present in the common ancestor of animals.

Orthologs for OTP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTP 35
  • 95.28 (n)
  • 100 (a)
OTP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTP 35
  • 94.15 (n)
  • 97.54 (a)
OTP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otp 35
  • 94.05 (n)
  • 100 (a)
Otp 16
Otp 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTP 35
  • 99.49 (n)
  • 100 (a)
OTP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otp 35
  • 94.05 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia OTP 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTP 35
  • 88.62 (n)
  • 96.92 (a)
OTP 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTP 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otp 35
  • 80.49 (n)
  • 90.19 (a)
zebrafish
(Danio rerio)
Actinopterygii otp 35
otpa 35
  • 76.45 (n)
  • 86.12 (a)
otpa 36
  • 83 (a)
OneToMany
otpb 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta otp 37
  • 72 (a)
otp 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToOne
Species with no ortholog for OTP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTP Gene

ENSEMBL:
Gene Tree for OTP (if available)
TreeFam:
Gene Tree for OTP (if available)

Paralogs for OTP Gene

Paralogs for OTP Gene

(3) SIMAP similar genes for OTP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTP: view

Variants for OTP Gene

Sequence variations from dbSNP and Humsavar for OTP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1055247 -- 77,636,176(-) GTTTT(G/T)TTTTG intron-variant, utr-variant-3-prime
rs6864981 -- 77,632,377(+) GATGT(A/G)GGACA intron-variant
rs6878934 -- 77,629,916(+) AGGCC(A/G)GGAGG utr-variant-3-prime
rs6879117 -- 77,629,995(+) GACCG(A/G)GCCGA utr-variant-3-prime
rs4549506 -- 77,640,108(+) GGCCC(A/T)ATGAA upstream-variant-2KB

Variation tolerance for OTP Gene

Gene Damage Index Score: 1.37; 27.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTP Gene

HapMap Linkage Disequilibrium report
OTP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OTP Gene

Disorders for OTP Gene

MalaCards: The human disease database

(1) MalaCards diseases for OTP Gene - From: DISEASES

Disorder Aliases PubMed IDs
skull base meningioma
  • meningioma of the skull base
- elite association - COSMIC cancer census association via MalaCards
Search OTP in MalaCards View complete list of genes associated with diseases

Relevant External Links for OTP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTP
genes like me logo Genes that share disorders with OTP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OTP Gene

Publications for OTP Gene

  1. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (PMID: 10458915) Lin X. … Leckman J.F. (Genomics 1999) 2 3 4 67
  2. CD44 and OTP are strong prognostic markers for pulmonary carcinoids. (PMID: 23444222) Swarts D.R. … Speel E.J. (Clin. Cancer Res. 2013) 3
  3. Genome-wide identification of OTP gene as a novel methylation marker of breast cancer. (PMID: 22366991) Kim M.S. … Lee J.H. (Oncol. Rep. 2012) 3
  4. A peek inside the neurosecretory brain through Orthopedia lenses. (PMID: 18729222) Del Giacco L. … Sordino P. (Dev. Dyn. 2008) 23
  5. Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. (PMID: 14988428) Goshu E. … Fan C.M. (Mol. Endocrinol. 2004) 23

Products for OTP Gene

Sources for OTP Gene

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