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Aliases for OTP Gene

Aliases for OTP Gene

  • Orthopedia Homeobox 2 3
  • Orthopedia Homolog (Drosophila) 2

External Ids for OTP Gene

Previous GeneCards Identifiers for OTP Gene

  • GC05M075730
  • GC05M077158
  • GC05M076963
  • GC05M077008
  • GC05M076960
  • GC05M072131
  • GC05M076924

Summaries for OTP Gene

Entrez Gene Summary for OTP Gene

  • This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

GeneCards Summary for OTP Gene

OTP (Orthopedia Homeobox) is a Protein Coding gene. Diseases associated with OTP include skull base meningioma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is PHOX2B.

UniProtKB/Swiss-Prot for OTP Gene

  • Probably involved in the differentiation of hypothalamic neuroendocrine cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTP Gene

Genomics for OTP Gene

Regulatory Elements for OTP Gene

Genomic Location for OTP Gene

Start:
77,628,712 bp from pter
End:
77,639,688 bp from pter
Size:
10,977 bases
Orientation:
Minus strand

Genomic View for OTP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTP Gene

Proteins for OTP Gene

  • Protein details for OTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKR4-OTP_HUMAN
    Recommended name:
    Homeobox protein orthopedia
    Protein Accession:
    Q5XKR4
    Secondary Accessions:

    Protein attributes for OTP Gene

    Size:
    325 amino acids
    Molecular mass:
    34159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTP Gene

Proteomics data for OTP Gene at MOPED

Post-translational modifications for OTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTP Gene

Domains for OTP Gene

Gene Families for OTP Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Suggested Antigen Peptide Sequences for OTP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKR4

UniProtKB/Swiss-Prot:

OTP_HUMAN :
  • Q5XKR4
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family. Bicoid subfamily.
genes like me logo Genes that share domains with OTP: view

Function for OTP Gene

Molecular function for OTP Gene

GENATLAS Biochemistry: orthopedia homolog gene,homeo domain gene,expressed in hypothalamus,amygdalia and brain
UniProtKB/Swiss-Prot Function: Probably involved in the differentiation of hypothalamic neuroendocrine cells

Gene Ontology (GO) - Molecular Function for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with OTP: view
genes like me logo Genes that share phenotypes with OTP: view

miRNA for OTP Gene

miRTarBase miRNAs that target OTP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OTP Gene

Localization for OTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTP Gene COMPARTMENTS Subcellular localization image for OTP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OTP: view

Pathways for OTP Gene

SuperPathways for OTP Gene

No Data Available

Interacting Proteins for OTP Gene

Gene Ontology (GO) - Biological Process for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021879 forebrain neuron differentiation IEA --
GO:0021979 hypothalamus cell differentiation IEA --
genes like me logo Genes that share ontologies with OTP: view

No data available for Pathways by source for OTP Gene

Transcripts for OTP Gene

mRNA/cDNA for OTP Gene

(43) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTP Gene

Orthopedia homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTP Gene

No ASD Table

Relevant External Links for OTP Gene

GeneLoc Exon Structure for
OTP
ECgene alternative splicing isoforms for
OTP

Expression for OTP Gene

mRNA expression in normal human tissues for OTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OTP Gene

This gene is overexpressed in Brain - Hypothalamus (48.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OTP Gene

SOURCE GeneReport for Unigene cluster for OTP Gene Hs.202247

genes like me logo Genes that share expressions with OTP: view

No data available for mRNA Expression by UniProt/SwissProt for OTP Gene

Orthologs for OTP Gene

This gene was present in the common ancestor of animals.

Orthologs for OTP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTP 35
  • 99.49 (n)
  • 100 (a)
OTP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTP 35
  • 95.28 (n)
  • 100 (a)
OTP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTP 35
  • 94.15 (n)
  • 97.54 (a)
OTP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otp 35
  • 94.05 (n)
  • 100 (a)
Otp 16
Otp 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OTP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otp 35
  • 94.05 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves OTP 35
  • 88.62 (n)
  • 96.92 (a)
OTP 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTP 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otp 35
  • 80.49 (n)
  • 90.19 (a)
zebrafish
(Danio rerio)
Actinopterygii otp 35
otpa 35
  • 76.45 (n)
  • 86.12 (a)
otpa 36
  • 83 (a)
OneToMany
otpb 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta otp 36
  • 33 (a)
OneToOne
otp 37
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToOne
Species with no ortholog for OTP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTP Gene

ENSEMBL:
Gene Tree for OTP (if available)
TreeFam:
Gene Tree for OTP (if available)

Paralogs for OTP Gene

Paralogs for OTP Gene

Selected SIMAP similar genes for OTP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTP: view

Variants for OTP Gene

Sequence variations from dbSNP and Humsavar for OTP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1055247 -- 77,636,176(-) GTTTT(G/T)TTTTG intron-variant
rs2241367 -- 77,636,400(+) TCTGT(A/G)TAATT intron-variant
rs2279010 -- 77,632,932(+) GGCCG(A/C)AAGTC intron-variant
rs2290690 -- 77,639,213(+) CGCCT(A/G)GACTT upstream-variant-2KB
rs2290691 -- 77,639,583(+) GAACA(A/G)TTTAA upstream-variant-2KB

Relevant External Links for OTP Gene

HapMap Linkage Disequilibrium report
OTP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OTP Gene

Disorders for OTP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OTP Gene including...

Search for OTP Gene in MalaCards »

(1) University of Copenhagen DISEASES for OTP Gene

genes like me logo Genes that share disorders with OTP: view

No data available for UniProtKB/Swiss-Prot for OTP Gene

Publications for OTP Gene

  1. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (PMID: 10458915) Lin X. … Leckman J.F. (Genomics 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Genome-wide identification of OTP gene as a novel methylation marker of breast cancer. (PMID: 22366991) Kim M.S. … Lee J.H. (Oncol. Rep. 2012) 3
  4. CD44 and OTP are strong prognostic markers for pulmonary carcinoids. (PMID: 23444222) Swarts D.R. … Speel E.J. (Clin. Cancer Res. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OTP Gene

Sources for OTP Gene

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