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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTP Gene

protein-coding   GIFtS: 47
GCID: GC05M076960

Orthopedia Homeobox

(Previous name: orthopedia homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Orthopedia Homeobox1 2
Orthopedia Homolog (Drosophila)1
Homeobox Protein Orthopedia2
Orthopedia Homolog2

External Ids:    HGNC: 85181   Entrez Gene: 234402   Ensembl: ENSG000001715407   OMIM: 6045295   UniProtKB: Q5XKR43   

Export aliases for OTP gene to outside databases

Previous GC identifers: GC05M075730 GC05M077158 GC05M076963 GC05M077008 GC05M072131


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OTP Gene:
This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription
factors that play key roles in the specification of cell fates. This protein may function during brain
development. (provided by RefSeq, Jul 2008)

GeneCards Summary for OTP Gene: 
OTP (orthopedia homeobox) is a protein-coding gene. Diseases associated with OTP include skull base meningioma, and typhus. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4
Function: Probably involved in the differentiation of hypothalamic neuroendocrine cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTP gene promoter:
         E2F-3a   E2F-4   E2F   E2F-1   NRSF form 1   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTP promoter sequence
   Search SABiosciences Chromatin IP Primers for OTP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

OTP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M076960:  view genomic region     (about GC identifiers)

Start:
76,924,537 bp from pter      End:
76,935,513 bp from pter
Size:
10,977 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4 (See protein sequence)
Recommended Name: Homeobox protein orthopedia  
Size: 325 amino acids; 34159 Da
Subcellular location: Nucleus
Developmental stage: Present in fetal hypothalamus at 19 weeks of gestation (at protein level)

Explore the universe of human proteins at neXtProt for OTP: NX_Q5XKR4

Explore proteomics data for OTP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5XKR4

  • OTP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OTP Protein Expression
    REFSEQ proteins: NP_115485.1  
    ENSEMBL proteins: 
     ENSP00000302814  

    Human Recombinant Protein Products for OTP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    GenScript Custom Purified and Recombinant Proteins Services for OTP
    Novus Biologicals OTP Proteins
    Novus Biologicals OTP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OTP 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    OTP for ontologies           About GeneDecksing



    OTP Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for OTP 

    Assay Products for OTP: 
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    Cloud-Clone Corp. ELISAs for OTP 
    Cloud-Clone Corp. CLIAs for OTP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    5 InterPro protein domains:
     IPR003654 OAR_dom
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q5XKR4

    ProtoNet protein and cluster: Q5XKR4

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    OTP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTP_HUMAN, Q5XKR4
    Function: Probably involved in the differentiation of hypothalamic neuroendocrine cells

         Genatlas biochemistry entry for OTP:
    orthopedia homolog gene,homeo domain gene,expressed in hypothalamus,amygdalia and brain

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    OTP for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Otp):
     endocrine/exocrine gland  growth/size  mortality/aging  nervous system 

    OTP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OTP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OTP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTP
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate OTP (see all 67):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-605 hsa-miR-3653 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-371-5p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidOTP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OTP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for OTP
    Sirion Biotech Customized adenovirus for overexpression of OTP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OTP (see all 6)
    OriGene ORF clones in mouse, rat for OTP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTP (NM_032109)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTP
    Sirion Biotech Customized lentivirus for stable overexpression of OTP 
                         Customized lentivirus expression plasmids for stable overexpression of OTP 

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    GenScript Custom overexpressing Cell Line Services for OTP
    Search LifeMap BioReagents cell lines for OTP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTP

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0021879forebrain neuron differentiation IEA--
    GO:0021979hypothalamus cell differentiation IEA--

    OTP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTP

    Search CenterWatch for drugs/clinical trials and news about OTP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OTP gene: 
    NM_032109.2  

    Unigene Cluster for OTP:

    Orthopedia homeobox
    Hs.202247  [show with all ESTs]
    Unigene Representative Sequence: BC001800
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306422(uc003kfg.3) ENST00000515716
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTP
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate OTP (see all 67):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-605 hsa-miR-3653 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-371-5p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidOTP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OTP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTP
    Clone
    Products:
         
    OriGene clones in human, mouse for OTP (see all 6)
    OriGene ORF clones in mouse, rat for OTP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTP (NM_032109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTP
    Sirion Biotech Customized lentivirus for stable overexpression of OTP 
                         Customized lentivirus expression plasmids for stable overexpression of OTP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OTP
    OriGene qSTAR qPCR primer pairs in human, mouse for OTP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTP

    Additional mRNA sequence: BC001800.1 

    1 DOTS entry:

    DT.306772 

    24/43 AceView cDNA sequences (see all 43):

    AA973827 AI791231 AA808516 AW134781 AI702277 AI791530 NM_032109 AI733154 
    BE550799 BC001800 BF224340 BE327227 BE221936 AI300650 BE219632 AI216636 
    AA885674 BE043048 AA989337 BX115723 AA983693 BG149703 AI693303 BE618117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTP expression in normal human tissues (normalized intensities)      OTP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGTCAA
    OTP Expression
    About this image


    OTP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See OTP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTP

    SOURCE GeneReport for Unigene cluster: Hs.202247
        SABiosciences Expression via Pathway-Focused PCR Array including OTP: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OTP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otp1 , 5 orthopedia homolog (Drosophila)1, 5 94.05(n)1
    100(a)1
      13 (49.22 cM)5
    184201  NM_011021.31  NP_035151.11 
     948756275 
    chicken
    (Gallus gallus)
    Aves OTP1 orthopedia homeobox 88.62(n)
    96.92(a)
      554220  XM_003642956.1  XP_003643004.1 
    lizard
    (Anolis carolinensis)
    Reptilia OTP6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    2(13857654-13870597)
    zebrafish
    (Danio rerio)
    Actinopterygii otp2 orthopedia protein 75.44(n)   30316  AF071496.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta otp1 , 3 central nervous system development DNA
    binding3
    orthopedia1
    72(a)3
    56.26(n)1
    51.58(a)1
      2 57B43
    373641  NM_001043098.11  NP_001036563.11 


    ENSEMBL Gene Tree for OTP (if available)
    TreeFam Gene Tree for OTP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTP gene
    ALX12  PHOX2B2  ARX2  RAX2  DRGX2  PRRX12  SHOX22  PHOX2A2  
    ALX42  ISX2  RAX22  ALX32  SHOX2  PRRX22  
    3 SIMAP similar genes for OTP using alignment to 1 protein entry:     OTP_HUMAN:
    PRRX2    RAX2    PHOX2A

    OTP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/235 SNPs in OTP are shown (see all 235)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100368991,2
    C,F,H--76924133(+) TGCGAA/GTTGTG 1 -- ds500119Minor allele frequency- G:0.39NS EA NA CSA WA 2343
    rs1924723711,2
    C--76924241(+) CTCGCG/TCCCTG 1 -- ds50010--------
    rs1844514891,2
    --76924498(+) CCTCCC/TGCCGT 1 -- ds50010--------
    rs100554041,2
    C,F,H--76924534(+) TCTCTA/GTATCA 1 -- ds500115Minor allele frequency- G:0.15NS EA NA CSA 1828
    rs1399854551,2
    C--76924616(+) ATATGC/GTTTAT 1 -- ut310--------
    rs1896943431,2
    --76924649(+) AAAACC/GGAATT 1 -- ut310--------
    rs791648381,2
    C,F--76925132(+) ACTCCA/TGCCAC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1167318661,2
    C,F--76925183(+) TACACT/ACTCAC 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1425997021,2
    --76925237(+) AAAGCA/GTTATC 1 -- ut310--------
    rs2008582261,2
    C--76925284(+) GTGGA-/CTGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OTP (76924537 - 76935513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OTP: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OTP
    DNA2.0 Custom Variant and Variant Library Synthesis for OTP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604529    OMIM disorders: --

    7 diseases for OTP:    About MalaCards
    skull base meningioma    typhus    scrub typhus    substance abuse
    meningioma    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for OTP:
    Skull base meningioma

    OTP for disorders           About GeneDecksing


    Export disorders for OTP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OTP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (PubMed id 10458915)1, 2, 3 Lin X.... Leckman J.F. (1999)
    2. Genome-wide identification of OTP gene as a novel meth ylation marker of breast cancer. (PubMed id 22366991)1 Kim M.S....Lee J.H. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. A peek inside the neurosecretory brain through Orthopedia lenses. (PubMed id 18729222)9 Del Giacco L....Sordino P. (2008)
    6. Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. (PubMed id 14988428)9 Goshu E....Fan C.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23440 HGNC: 8518 AceView: OTP Ensembl:ENSG00000171540 euGenes: HUgn23440
    ECgene: OTP H-InvDB: OTP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OTP gene:
    Search GeneIP for patents involving OTP

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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