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OTP Gene

protein-coding   GIFtS: 48
GCID: GC05M076924

Orthopedia Homeobox

(Previous name: orthopedia homolog (Drosophila))
  See OTP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Orthopedia Homeobox1 2
Orthopedia Homolog (Drosophila)1
Homeobox Protein Orthopedia2
Orthopedia Homolog2

External Ids:    HGNC: 85181   Entrez Gene: 234402   Ensembl: ENSG000001715407   OMIM: 6045295   UniProtKB: Q5XKR43   

Export aliases for OTP gene to outside databases

Previous GC identifers: GC05M075730 GC05M077158 GC05M076963 GC05M077008 GC05M076960 GC05M072131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTP Gene:
This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription
factors that play key roles in the specification of cell fates. This protein may function during brain
development. (provided by RefSeq, Jul 2008)

GeneCards Summary for OTP Gene:
OTP (orthopedia homeobox) is a protein-coding gene. Diseases associated with OTP include skull base meningioma, and meningioma. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4
Function: Probably involved in the differentiation of hypothalamic neuroendocrine cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTP gene promoter:
         E2F-3a   E2F-4   E2F   E2F-1   NRSF form 1   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTP promoter sequence
   Search Chromatin IP Primers for OTP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

OTP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M076924:  view genomic region     (about GC identifiers)

Start:
76,924,537 bp from pter      End:
76,935,513 bp from pter
Size:
10,977 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4 (See protein sequence)
Recommended Name: Homeobox protein orthopedia  
Size: 325 amino acids; 34159 Da
Developmental stage: Present in fetal hypothalamus at 19 weeks of gestation (at protein level)

Explore the universe of human proteins at neXtProt for OTP: NX_Q5XKR4

Explore proteomics data for OTP at MOPED


See OTP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_115485.1  
ENSEMBL proteins: 
 ENSP00000302814  

OTP Human Recombinant Protein Products:

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antibodies-online proteins for OTP (5 products) 

 
antibodies-online peptides for OTP

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antibodies-online kits for OTP (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

5 InterPro protein domains:
 IPR003654 OAR_dom
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q5XKR4

ProtoNet protein and cluster: Q5XKR4

2 Blocks protein domains:
IPB000047 Lambda and other repressor helix-turn-helix signature
IPB003654 Paired-like homeodomain protein


UniProtKB/Swiss-Prot: OTP_HUMAN, Q5XKR4
Similarity: Belongs to the paired homeobox family. Bicoid subfamily
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with OTP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: OTP_HUMAN, Q5XKR4
Function: Probably involved in the differentiation of hypothalamic neuroendocrine cells

     Genatlas biochemistry entry for OTP:
orthopedia homolog gene,homeo domain gene,expressed in hypothalamus,amygdalia and brain

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding ----
     
Find genes that share ontologies with OTP           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Otp):
 endocrine/exocrine gland  growth/size/body  mortality/aging  nervous system 

Find genes that share phenotypes with OTP           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for OTP

miRNA
Products:
    
miRTarBase miRNAs that target OTP:
hsa-mir-30c-5p (MIRT047869)

Block miRNA regulation of human, mouse, rat OTP using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate OTP (see all 67):
hsa-miR-411* hsa-miR-576-3p hsa-miR-605 hsa-miR-3653 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-371-5p hsa-miR-298
SwitchGear 3'UTR luciferase reporter plasmidOTP 3' UTR sequence
Inhib. RNA
Products:
    
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Predesigned siRNA for gene silencing in human, mouse, rat OTP

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DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTP

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OTP_HUMAN, Q5XKR4: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with OTP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including OTP: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for OTP

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for OTP (ENSP000003028144) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CHEK2ENSP000003720234STRING: ENSP00000372023
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002052positive regulation of neuroblast proliferation IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0021879forebrain neuron differentiation IEA--
GO:0021979hypothalamus cell differentiation IEA--

Find genes that share ontologies with OTP           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OTP



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OTP gene: 
NM_032109.2  

Unigene Cluster for OTP:

Orthopedia homeobox
Hs.202247  [show with all ESTs]
Unigene Representative Sequence: BC001800
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000306422(uc003kfg.3) ENST00000515716
miRNA
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Block miRNA regulation of human, mouse, rat OTP using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate OTP (see all 67):
hsa-miR-411* hsa-miR-576-3p hsa-miR-605 hsa-miR-3653 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-371-5p hsa-miR-298
SwitchGear 3'UTR luciferase reporter plasmidOTP 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat OTP
Clone
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OriGene clones in human, mouse for OTP (see all 6)
OriGene ORF clones in mouse, rat for OTP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: OTP (NM_032109)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTP
Primer
Products:
    
OriGene qPCR primer pairs and template standards for OTP
OriGene qSTAR qPCR primer pairs in human, mouse for OTP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTP
  QuantiTect SYBR Green Assays in human, mouse, rat OTP
  QuantiFast Probe-based Assays in human, mouse, rat OTP

Additional mRNA sequence: BC001800.1 

1 DOTS entry:

DT.306772 

Selected AceView cDNA sequences (see all 43):

NM_032109 AW134781 BC001800 BE550799 BE221936 BE327227 BF224340 AA973827 
AI791231 AI791530 BE219632 AI216636 AI733154 AI300650 AI702277 AA808516 
AA885674 BE669547 AW770476 AA989337 AI733040 AI214636 AA983693 AI279269 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OTP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCTGGTCAA
OTP Expression
About this image


OTP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Metencephalon
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Neurons
         Ventral/hypothalamic-like neurons
 
 Kidney (Urinary System)
         Metanephros
 
 Eye (Sensory Organs)
         Retina
OTP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OTP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.202247
    Pathway & Disease-focused RT2 Profiler PCR Array including OTP: 
          Homeobox (HOX) Genes in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for OTP
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QuantiFast Probe-based Assays in human, mouse, rat OTP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for OTP gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Otp1 , 5 orthopedia homolog (Drosophila)1, 5 94.05(n)1
100(a)1
  13 (49.22 cM)5
184201  NM_011021.31  NP_035151.11 
 948756025 
chicken
(Gallus gallus)
Aves OTP1 orthopedia homeobox 88.62(n)
96.92(a)
  554220  XM_003642956.2  XP_003643004.1 
lizard
(Anolis carolinensis)
Reptilia OTP6
orthopedia homeobox
85(a)
1 ↔ 1
2(13857654-13870597)
tropical clawed frog
(Xenopus tropicalis)
Amphibia otp1 orthopedia homeobox 80.49(n)
90.19(a)
  100490162  XM_002940870.2  XP_002940916.1 
zebrafish
(Danio rerio)
Actinopterygii otp2 orthopedia protein 75.44(n)   30316  AF071496.2 
fruit fly
(Drosophila melanogaster)
Insecta otp3 central nervous system development DNA
binding
72(a)   2 57B4   --


ENSEMBL Gene Tree for OTP (if available)
TreeFam Gene Tree for OTP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OTP gene
ALX12  PHOX2B2  ARX2  RAX2  DRGX2  SHOX22  PRRX12  PHOX2A2  
ALX42  ISX2  RAX22  ALX32  SHOX2  PRRX22  
3 SIMAP similar genes for OTP using alignment to 1 protein entry:     OTP_HUMAN:
PRRX2    RAX2    PHOX2A

Find genes that share paralogs with OTP           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OTP (see all 235)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs100368991,2
C,F,H--76924133(+) TGCGAA/GTTGTG 1 -- ds500119Minor allele frequency- G:0.39NS EA NA CSA WA 2343
rs1924723711,2
C--76924241(+) CTCGCG/TCCCTG 1 -- ds50010--------
rs1844514891,2
--76924498(+) CCTCCC/TGCCGT 1 -- ds50010--------
rs100554041,2
C,F,H--76924534(+) TCTCTA/GTATCA 1 -- ds500115Minor allele frequency- G:0.15NS EA NA CSA 1828
rs1399854551,2
C--76924616(+) ATATGC/GTTTAT 1 -- ut310--------
rs1896943431,2
--76924649(+) AAAACC/GGAATT 1 -- ut310--------
rs791648381,2
C,F--76925132(+) ACTCCA/TGCCAC 1 -- ut311Minor allele frequency- T:0.02WA 118
rs1167318661,2
C,F--76925183(+) TACACT/ACTCAC 1 -- ut311Minor allele frequency- A:0.01WA 118
rs1425997021,2
--76925237(+) AAAGCA/GTTATC 1 -- ut310--------
rs2008582261,2
C--76925284(+) GTGGA-/CTGGGC 1 -- ut310--------

HapMap Linkage Disequilibrium report for OTP (76924537 - 76935513 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OTP: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OTP
DNA2.0 Custom Variant and Variant Library Synthesis for OTP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604529    OMIM disorders: --

2 diseases for OTP:    
About MalaCards
skull base meningioma    meningioma

1 disease from the University of Copenhagen DISEASES database for OTP:
Skull base meningioma

Find genes that share disorders with OTP           About GenesLikeMe


Export disorders for OTP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OTP gene integrated from 10 sources:
(articles sorted by number of sources associating them with OTP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (PubMed id 10458915)1, 2, 3 Lin X.... Leckman J.F. (Genomics 1999)
  2. CD44 and OTP are strong prognostic markers for pulmonary carcinoids. (PubMed id 23444222)1 Swarts D.R....Speel E.J. (Clin. Cancer Res. 2013)
  3. Genome-wide identification of OTP gene as a novel methylation marker of breast cancer. (PubMed id 22366991)1 Kim M.S....Lee J.H. (Oncol. Rep. 2012)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. A peek inside the neurosecretory brain through Orthopedia lenses. (PubMed id 18729222)9 Del Giacco L....Sordino P. (Dev. Dyn. 2008)
  7. Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. (PubMed id 14988428)9 Goshu E....Fan C.M. (Mol. Endocrinol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23440 HGNC: 8518 AceView: OTP Ensembl:ENSG00000171540 euGenes: HUgn23440
ECgene: OTP H-InvDB: OTP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OTP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OTP gene:
Search GeneIP for patents involving OTP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 EMD Millipore genomic analysis products

  
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OTP  
 OriGene qPCR primer pairs and template standards for OTP   OriGene Protein Over-expression Lysate for OTP  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for OTP  
 OriGene qSTAR qPCR primer pairs in human, mouse for OTP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for OTP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for OTP   OriGene Custom Protein Services for OTP  

 
 
 Block miRNA regulation of human, mouse, rat OTP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OTP
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTP Predesigned siRNA for gene silencing in human, mouse, rat OTP
 QuantiFast Probe-based Assays in human, mouse, rat OTP QuantiTect SYBR Green Assays in human, mouse, rat OTP
 PCR Arrays including human, mouse, rat OTP Search Chromatin IP Primers for OTP
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTP  Search GeneGlobe Interaction Network for OTP
 Regulatory tfbs in OTP promoter
 GenScript Custom Purified and Recombinant Proteins Services for OTP GenScript cDNA clones with any tag delivered in your preferred vector for OTP
 GenScript Custom Assay Services for OTP GenScript Custom overexpressing Cell Line Services for OTP
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for OTP
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 Proteins for OTP
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 Browse ESI BIO Cell Lines and PureStem Progenitors for OTP
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTP
 SwitchGear 3'UTR luciferase reporter plasmids for OTP
 SwitchGear Promoter luciferase reporter plasmids for OTP
 ThermoFisher Antibodies for OTP
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTP
 Browse compounds at ApexBio
 Search Addgene for plasmids for OTP
  Search eBioscience for proteins for OTP
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for OTP
 antibodies-online antibodies for OTP (28 products)
 antibodies-online kits for OTP (4 products)
 antibodies-online peptides for OTP
 antibodies-online proteins for OTP (5 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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