Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OTOS Gene

Aliases for OTOS Gene

  • Otospiralin 2 3 5
  • OTOSP 3 4

External Ids for OTOS Gene

Previous GeneCards Identifiers for OTOS Gene

  • GC02M241399
  • GC02M240798
  • GC02M241078
  • GC02M232836

Summaries for OTOS Gene

Entrez Gene Summary for OTOS Gene

  • Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OTOS Gene

OTOS (Otospiralin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OTOS Gene

  • May be essential for the survival of the neurosensory epithelium of the inner ear.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTOS Gene

Genomics for OTOS Gene

Regulatory Elements for OTOS Gene

Enhancers for OTOS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OTOS on UCSC Golden Path with GeneCards custom track

Genomic Location for OTOS Gene

240,139,026 bp from pter
240,144,562 bp from pter
5,537 bases
Minus strand

Genomic View for OTOS Gene

Genes around OTOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTOS Gene

Proteins for OTOS Gene

  • Protein details for OTOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q53SW6

    Protein attributes for OTOS Gene

    89 amino acids
    Molecular mass:
    9939 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTOS Gene

Proteomics data for OTOS Gene at MOPED

Post-translational modifications for OTOS Gene

No Post-translational modifications

Other Protein References for OTOS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTOS Gene

Domains & Families for OTOS Gene

Protein Domains for OTOS Gene


Suggested Antigen Peptide Sequences for OTOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the otospiralin family.
  • Belongs to the otospiralin family.
genes like me logo Genes that share domains with OTOS: view

No data available for Gene Families for OTOS Gene

Function for OTOS Gene

Molecular function for OTOS Gene

UniProtKB/Swiss-Prot Function:
May be essential for the survival of the neurosensory epithelium of the inner ear.
genes like me logo Genes that share phenotypes with OTOS: view

Animal Models for OTOS Gene

MGI Knock Outs for OTOS:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OTOS Gene

Localization for OTOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTOS Gene


Subcellular locations from

Jensen Localization Image for OTOS Gene COMPARTMENTS Subcellular localization image for OTOS gene
Compartment Confidence
extracellular 4

No data available for Gene Ontology (GO) - Cellular Components for OTOS Gene

Pathways & Interactions for OTOS Gene

SuperPathways for OTOS Gene

No Data Available

Interacting Proteins for OTOS Gene

Gene Ontology (GO) - Biological Process for OTOS Gene


No data available for Pathways by source and SIGNOR curated interactions for OTOS Gene

Drugs & Compounds for OTOS Gene

(1) Drugs for OTOS Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
genes like me logo Genes that share compounds with OTOS: view

Transcripts for OTOS Gene

mRNA/cDNA for OTOS Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTOS Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTOS Gene

No ASD Table

Relevant External Links for OTOS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTOS Gene

mRNA expression in normal human tissues for OTOS Gene

mRNA differential expression in normal tissues according to GTEx for OTOS Gene

This gene is overexpressed in Pituitary (x32.2) and Thyroid (x6.7).

SOURCE GeneReport for Unigene cluster for OTOS Gene Hs.148586

mRNA Expression by UniProt/SwissProt for OTOS Gene

Tissue specificity: Ear specific.
genes like me logo Genes that share expression patterns with OTOS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OTOS Gene

Orthologs for OTOS Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTOS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OTOS 35
  • 88.01 (n)
  • 87.64 (a)
  • 93 (a)
(Canis familiaris)
Mammalia OTOS 35
  • 87.64 (n)
  • 88.76 (a)
  • 87 (a)
(Mus musculus)
Mammalia Otos 35
  • 82.4 (n)
  • 79.78 (a)
Otos 16
Otos 36
  • 79 (a)
(Pan troglodytes)
Mammalia OTOS 35
  • 98.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Otos 35
  • 81.27 (n)
  • 80.9 (a)
(Monodelphis domestica)
Mammalia OTOS 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia OTOS 36
  • 58 (a)
(Anolis carolinensis)
Reptilia OTOS 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otos 35
  • 68.82 (n)
  • 67.74 (a)
(Danio rerio)
Actinopterygii OTOS 36
  • 48 (a)
Species with no ortholog for OTOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTOS Gene

Gene Tree for OTOS (if available)
Gene Tree for OTOS (if available)

Paralogs for OTOS Gene

No data available for Paralogs for OTOS Gene

Variants for OTOS Gene

Sequence variations from dbSNP and Humsavar for OTOS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35889242 - 240,140,307(+) GCCCC(A/G/T)GCACC reference, missense
rs508944 -- 240,140,467(-) TTTTT(A/T)AAATC intron-variant
rs520679 -- 240,142,420(+) GTGAA(A/G)AAGGG upstream-variant-2KB
rs1659925 -- 240,141,214(+) AGGGT(C/T)TCTGT upstream-variant-2KB
rs1659926 -- 240,141,216(+) GGTCT(C/T)TGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTOS Gene

Variant ID Type Subtype PubMed ID
nsv876099 CNV Gain 21882294
nsv483047 CNV Loss 15286789
nsv876115 CNV Loss 21882294

Variation tolerance for OTOS Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OTOS Gene

Disorders for OTOS Gene

Relevant External Links for OTOS

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OTOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTOS Gene

Publications for OTOS Gene

  1. Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin. (PMID: 12687421) Lavigne-Rebillard M. … Hamel C.P. (Neurogenetics 2003) 2 3 4 23 67
  2. Genetic variation in Otos is associated with cisplatin-induced ototoxicity. (PMID: 25410892) Spracklen T.F. … Ramesar R.S. (Pharmacogenomics 2014) 3
  3. [Intervention of spiral ligament fibrocytes in the metabolic regulation of the inner ear]. (PMID: 19080786) GarcA-a Berrocal J.R. … RamA-rez Camacho R. (Acta Otorrinolaringol Esp 2008) 23
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  5. Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. (PMID: 15632083) Delprat B. … Hamel C.P. (Mol. Cell. Biol. 2005) 23

Products for OTOS Gene

Sources for OTOS Gene