OTOS Gene
protein-coding GIFtS: 38
GCID: GC02M241078
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otospiralin
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Aliases
for OTOS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Otospiralin1 | | OTOSP1 2 3 5 |
Export aliases for OTOS gene to outside databasesPrevious GC identifers: GC02M241399 GC02M240798 GC02M232836 |
Summaries
for OTOS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OTOS:
Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin inguinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 (PubMed 12687421)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: OTOSP_HUMAN, Q8NHW6Function: May be essential for the survival of the neurosensory epithelium of the inner ear (By similarity)
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Genomic Views
for OTOS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OTOS gene promoter:
PPAR-gamma1 Lmo2 Hand1 AP-4 PPAR-gamma2 ATF E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for OTOS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3OTOS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M241078: view genomic region
(about GC identifiers)
Start:
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241,078,446 bp from pter |
End:
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241,083,979 bp from pter |
Size:
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5,534 bases |
Orientation:
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minus strand |
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Proteins
for OTOS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OTOSP_HUMAN, Q8NHW6 (See
protein sequence)Recommended Name: Otospiralin precursor Size: 89 amino acids; 9939 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q53SW6Explore the universe of human proteins at neXtProt for OTOS: NX_Q8NHW6
OTOS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_683764.1
ENSEMBL proteins: ENSP00000375849 ENSP00000322486
Human Recombinant Protein Products for OTOS:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
OTOS for ontologies About GeneDecksing
OTOS Antibody Products:
Assay Products for OTOS: |
Protein
Domains /
Families
for OTOS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NHW6 UniProtKB/Swiss-Prot: OTOSP_HUMAN, Q8NHW6Similarity: Belongs to the otospiralin family |
Function
for OTOS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OTOSP_HUMAN, Q8NHW6Function: May be essential for the survival of the neurosensory epithelium of the inner ear (By similarity)Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Otos):
OTOS for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Otostm1Cham for OTOS
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OTOS (NM_148961) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTOS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOS |
|
Pathways & Interactions
for OTOS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTOS
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007605 | sensory perception of sound |
IEA | -- |
OTOS for ontologies About GeneDecksing
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Drugs & Compounds
for OTOS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OTOS
Search CenterWatch for drugs/clinical trials and news about OTOS / OTOSP
|
Transcripts
for OTOS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OTOS gene: NM_148961.3 Unigene Cluster for OTOS: Otospiralin Hs.148586 [show with all ESTs]Unigene Representative Sequence: NM_1489612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391989 ENST00000319460(uc002vyv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OTOS (NM_148961) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTOS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOS |
Additional cDNA sequence: BC105085.1 BC105087.1 1 DOTS entry: DT.100035501 9 AceView cDNA sequences: BX118794 NM_148961 AI494286 AI201810 AI939423 BF509701 CD251340 AW772596 AI871046
GeneLoc Exon Structure
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Expression
for OTOS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OTOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCCCCGC
About this image
See OTOS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OTOS
SOURCE GeneReport for Unigene cluster: Hs.148586
UniProtKB/Swiss-Prot: OTOSP_HUMAN, Q8NHW6Tissue specificity: Ear specific
SABiosciences Custom PCR Arrays for OTOS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTOS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOS |
Orthologs
for OTOS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OTOS gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for OTOS (if available)
TreeFam Gene Tree for OTOS (if available) |
Paralogs
for OTOS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OTOS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OTOS (241078446 - 241083979 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OTOS
1 CNV: 0031 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OTOS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 OTOS for disorders About MalaCards
OTOS for disorders About GeneDecksing
OMIM gene information: 607877
OMIM disorders: --
1 disease from the University of Copenhagen DISEASES database for OTOS:Vestibular disease Export disorders for OTOS gene to outside databases
|
Publications
for OTOS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OTOS gene integrated from 9 sources:
(articles sorted by number of sources associating them with OTOS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin. (PubMed id 12687421)1, 2, 3, 9 Lavigne-Rebillard M.... Hamel C.P. (2003)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Down regulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness. (PubMed id 11880501)1, 2 Delprat B....Hamel C.P. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. (PubMed id 15632083)9 Delprat B....Hamel C.P. (2005)
- [Intervention of spiral ligament fibrocytes in the metabolic regulation of the inner ear] (PubMed id 19080786)9 GarcA-a Berrocal J.R....RamA-rez Camacho R. (2008)
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External Searches for OTOS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OTOS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OTOS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OTOS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OTOS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OTOS gene:
Search GeneIP for patents involving OTOS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OTOS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OTOS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OTOS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTOS | | | OriGene Protein Over-expression Lysate for OTOS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OTOS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OTOS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OTOS | | OriGene Custom Protein Services for OTOS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OTOS | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTOS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOS |
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| | | | Search Tocris compounds for OTOS |
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 | | | OTOS Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for OTOS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOS |
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