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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OTOR Gene

protein-coding   GIFtS: 55
GCID: GC20P016729

Otoraplin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
otoraplin1 2
Fibrocyte-Derived Protein2 3
Melanoma Inhibitory Activity-Like Protein2 3
FDP2 3
MIAL12
MIAL3

External Ids:    HGNC: 85171   Entrez Gene: 569142   Ensembl: ENSG000001258797   OMIM: 6060675   UniProtKB: Q9NRC93   

Export aliases for OTOR gene to outside databases

Previous GC identifers: GC20P016717 GC20P016724 GC20P016677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OTOR Gene:
This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via
the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the
translation start codon of this gene can abolish translation and may be associated with forms of deafness.
(provided by RefSeq, Jul 2013)

GeneCards Summary for OTOR Gene: 
OTOR (otoraplin) is a protein-coding gene. Diseases associated with OTOR include melanoma, and pulmonary embolism. An important paralog of this gene is MIA-RAB4B.

Gene Wiki entry for OTOR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OTOR gene promoter:
         MEF-2A   PPAR-gamma1   FOXF2   AP-1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTOR promoter sequence
   Search SABiosciences Chromatin IP Primers for OTOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1-p11.23   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1-p11.23

OTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTOR gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P016729:  view genomic region     (about GC identifiers)

Start:
16,729,003 bp from pter      End:
16,750,707 bp from pter
Size:
21,705 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9 (See protein sequence)
Recommended Name: Otoraplin precursor  
Size: 128 amino acids; 14332 Da
Subcellular location: Secreted (Potential)
Secondary accessions: D3DW22 Q3MIU6

Explore the universe of human proteins at neXtProt for OTOR: NX_Q9NRC9

Explore proteomics data for OTOR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRC9

  • OTOR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OTOR Protein Expression
    REFSEQ proteins: NP_064542.1  
    ENSEMBL proteins: 
     ENSP00000246081  

    Human Recombinant Protein Products for OTOR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for OTOR
    OriGene MassSpec for OTOR 
    OriGene Custom Protein Services for OTOR
    GenScript Purified and Recombinant Proteins for OTOR
    Novus Biologicals OTOR Proteins
    Novus Biologicals OTOR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for OTOR
    Cloud-Clone Corp. Proteins for OTOR 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    OTOR for ontologies           About GeneDecksing



    OTOR Antibody Products: 
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    Abcam antibodies for OTOR
    Cloud-Clone Corp. Antibodies for OTOR 
    ThermoFisher Antibodies for OTOR
    LSBio Antibodies in human, mouse, rat for OTOR 

    Assay Products for OTOR: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OTOR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OTOR 
    Cloud-Clone Corp. CLIAs for OTOR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q9NRC9

    ProtoNet protein and cluster: Q9NRC9

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9
    Similarity: Belongs to the MIA/OTOR family
    Similarity: Contains 1 SH3 domain


    OTOR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    OTOR for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Otor (no phenotypes)

    OTOR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Otortm1Lex for OTOR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OTOR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OTOR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTOR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTOR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTOR
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate OTOR:
    hsa-miR-219-1-3p hsa-miR-7-2* hsa-miR-1276 hsa-miR-7-1* hsa-miR-802 hsa-miR-145 hsa-miR-330-3p hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidOTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTOR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OTOR
    Sirion Biotech Customized adenovirus for overexpression of OTOR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OTOR (see all 6)
    OriGene ORF clones in mouse, rat for OTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTOR (NM_020157)
    Sino Biological Human cDNA Clone for OTOR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOR
    Sirion Biotech Customized lentivirus for stable overexpression of OTOR 
                         Customized lentivirus expression plasmids for stable overexpression of OTOR 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OTOR
    Search LifeMap BioReagents cell lines for OTOR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTOR

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0007605sensory perception of sound TAS10873378

    OTOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OTOR

    Search CenterWatch for drugs/clinical trials and news about OTOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OTOR gene: 
    NM_020157.3  

    Unigene Cluster for OTOR:

    Otoraplin
    Hs.41119  [show with all ESTs]
    Unigene Representative Sequence: NM_020157
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246081(uc002wpj.3) ENST00000486129 ENST00000490148
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OTOR
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate OTOR:
    hsa-miR-219-1-3p hsa-miR-7-2* hsa-miR-1276 hsa-miR-7-1* hsa-miR-802 hsa-miR-145 hsa-miR-330-3p hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidOTOR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTOR
    Clone
    Products:
         
    OriGene clones in human, mouse for OTOR (see all 6)
    OriGene ORF clones in mouse, rat for OTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTOR (NM_020157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOR
    Sirion Biotech Customized lentivirus for stable overexpression of OTOR 
                         Customized lentivirus expression plasmids for stable overexpression of OTOR 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OTOR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTOR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOR

    Additional mRNA sequence: 

    AF233261.1 AF243505.1 AJ242552.1 AY359082.1 BC101688.1 BC101690.1 

    4 DOTS entries:

    DT.307722  DT.100844264  DT.92070627  DT.40239237 

    24/33 AceView cDNA sequences (see all 33):

    AF233261 NM_020157 AJ242552 CR624240 N68117 AY359082 N69775 BX444840 
    AF243505 BI492218 BE858557 N63222 BX418941 BI496734 N67179 BI495576 
    BX444839 BI495574 BI493047 AW022083 H88081 BI493008 BI495573 AW023324 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OTOR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:              -     -                     
    SP2:                                          


    ECgene alternative splicing isoforms for OTOR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OTOR expression in normal human tissues (normalized intensities)      OTOR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTTTCTA
    OTOR Expression
    About this image


    OTOR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer

    See OTOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OTOR

    SOURCE GeneReport for Unigene cluster: Hs.41119

    UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9
    Tissue specificity: Highly expressed in cochlea

        SABiosciences Custom PCR Arrays for OTOR
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OTOR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTOR
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OTOR gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otor1 , 5 otoraplin1, 5 84.11(n)1
    86.72(a)1
      2 (70.89 cM)5
    573291  NM_020595.21  NP_065620.11 
     1430784735 
    chicken
    (Gallus gallus)
    Aves OTOR1 otoraplin 72.58(n)
    75(a)
      395484  NM_204732.1  NP_990063.1 
    lizard
    (Anolis carolinensis)
    Reptilia OTOR6
    otoraplin
    58(a)
    1 ↔ 1
    1(127296933-127299461)


    ENSEMBL Gene Tree for OTOR (if available)
    TreeFam Gene Tree for OTOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OTOR gene
    MIA-RAB4B2  MIA2  
    4 SIMAP similar genes for OTOR using alignment to 1 protein entry:     OTOR_HUMAN:
    MIA    MIA3    MIA2    CTAGE5

    OTOR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/178 SNPs in OTOR are shown (see all 178)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61112681,2
    H--16727248(+) CTTTAG/AGAcag 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1926647391,2
    --16727257(+) AGGTGC/TGGTGG 1 -- us2k10--------
    rs1495080561,2
    C--16727458(+) CCTGGA/CGACAG 1 -- us2k10--------
    rs61358731,2
    C,F,A,H--16727808(+) TCACAC/TACACA 1 -- us2k110Minor allele frequency- T:0.19NS EA NA CSA WA 718
    rs61358741,2
    C,F,A--16727809(+) CACACA/GCACAC 1 -- us2k16Minor allele frequency- G:0.24NA CSA WA EA 364
    rs1841455781,2
    --16727810(+) ACACAA/CACACA 1 -- us2k10--------
    rs61358751,2
    C,F,A,H--16727859(+) TTACCC/AATTTA 1 -- us2k1105Minor allele frequency- A:0.27NS EA NA PA EU CA WA CSA 6083
    rs10184241,2
    C,F,O,A,H--16727996(-) ATGCCC/TTCTCC 1 -- us2k121Minor allele frequency- G:0.02EA NA NS WA CSA 1078
    rs1878852511,2
    C--16728004(+) CATCCG/TGAGAG 1 -- us2k10--------
    rs37612941,2
    C,F,A,H--16728029(-) ATCCAT/CTGCTT 1 -- us2k128Minor allele frequency- C:0.17NS EA NA CSA WA 2910

    HapMap Linkage Disequilibrium report for OTOR (16729003 - 16750707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OTOR:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv90n6CNV Loss16902084


    Human Gene Mutation Database (HGMD): OTOR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for OTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606067    OMIM disorders: --

    3 diseases for OTOR:    About MalaCards
    melanoma    pulmonary embolism    disseminated intravascular coagulation


    OTOR for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for OTOR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 43 6 11161796 (2), 10873378 (1)

    Genetic Association Database (GAD): OTOR
    Human Genome Epidemiology (HuGE) Navigator: OTOR (2 documents)

    Export disorders for OTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OTOR gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with OTOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. (PubMed id 10873378)1, 2, 3, 9 Robertson N.G.... Morton C.C. (2000)
    2. Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation. (PubMed id 11161796)1, 2, 9 Rendtorff N.D.... Tommerup N. (2001)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme. (PubMed id 10998416)1, 2 Cohen-Salmon M.... Petit C. (2000)
    9. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)4 Elks C.E....Murray A. (2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56914 HGNC: 8517 AceView: OTOR Ensembl:ENSG00000125879 euGenes: HUgn56914
    ECgene: OTOR H-InvDB: OTOR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OTOR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OTOR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OTOR gene:
    Search GeneIP for patents involving OTOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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