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OTOR Gene

protein-coding   GIFtS: 54
GCID: GC20P016729

Otoraplin

  See OTOR-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
otoraplin1 2
Fibrocyte-Derived Protein2 3
Melanoma Inhibitory Activity-Like Protein2 3
FDP2 3
MIAL12
MIAL3

External Ids:    HGNC: 85171   Entrez Gene: 569142   Ensembl: ENSG000001258797   OMIM: 6060675   UniProtKB: Q9NRC93   
ORGUL members:         

Export aliases for OTOR gene to outside databases

Previous GC identifers: GC20P016717 GC20P016724 GC20P016677


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTOR Gene:
This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via
the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the
translation start codon of this gene can abolish translation and may be associated with forms of deafness.
(provided by RefSeq, Jul 2013)

GeneCards Summary for OTOR Gene:
OTOR (otoraplin) is a protein-coding gene. Diseases associated with OTOR include melanoma. An important paralog of this gene is MIA-RAB4B.

Gene Wiki entry for OTOR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTOR gene promoter:
         MEF-2A   PPAR-gamma1   FOXF2   AP-1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOTOR promoter sequence
   Search Chromatin IP Primers for OTOR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1-p11.23   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1-p11.23

OTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTOR gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P016729:  view genomic region     (about GC identifiers)

Start:
16,729,003 bp from pter      End:
16,750,707 bp from pter
Size:
21,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9 (See protein sequence)
Recommended Name: Otoraplin precursor  
Size: 128 amino acids; 14332 Da
Secondary accessions: D3DW22 Q3MIU6

Explore the universe of human proteins at neXtProt for OTOR: NX_Q9NRC9

Explore proteomics data for OTOR at MOPED


See OTOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_064542.1  
ENSEMBL proteins: 
 ENSP00000246081  

OTOR Human Recombinant Protein Products:

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OTOR Assay Products:

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Search eBioscience for ELISAs for OTOR 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR001452 SH3_domain
 IPR011511 SH3_2

Graphical View of Domain Structure for InterPro Entry Q9NRC9

ProtoNet protein and cluster: Q9NRC9

1 Blocks protein domain: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9
Similarity: Belongs to the MIA/OTOR family
Similarity: Contains 1 SH3 domain


Find genes that share domains with OTOR           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with OTOR           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Otor (no phenotypes)

Find genes that share phenotypes with OTOR           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Otortm1Lex for OTOR

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTOR
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTOR
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTOR

miRNA
Products:
    
miRTarBase miRNAs that target OTOR:
hsa-mir-335-5p (MIRT017617)

Block miRNA regulation of human, mouse, rat OTOR using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate OTOR:
hsa-miR-219-1-3p hsa-miR-7-2* hsa-miR-1276 hsa-miR-7-1* hsa-miR-802 hsa-miR-145 hsa-miR-330-3p hsa-miR-548n
SwitchGear 3'UTR luciferase reporter plasmidOTOR 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat OTOR

Gene Editing
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Clone
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OriGene clones in human, mouse for OTOR (see all 6)
OriGene ORF clones in mouse, rat for OTOR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: OTOR (NM_020157)
Sino Biological Human cDNA Clone for OTOR
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOR

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOR


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OTOR_HUMAN, Q9NRC9: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
golgi apparatus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with OTOR           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTOR
Interactions:

    Search GeneGlobe Interaction Network for OTOR

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001502cartilage condensation IEA--
GO:0007605sensory perception of sound TAS10873378

Find genes that share ontologies with OTOR           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OTOR



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OTOR gene: 
NM_020157.3  

Unigene Cluster for OTOR:

Otoraplin
Hs.41119  [show with all ESTs]
Unigene Representative Sequence: NM_020157
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000246081(uc002wpj.3) ENST00000486129 ENST00000490148
miRNA
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Block miRNA regulation of human, mouse, rat OTOR using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate OTOR:
hsa-miR-219-1-3p hsa-miR-7-2* hsa-miR-1276 hsa-miR-7-1* hsa-miR-802 hsa-miR-145 hsa-miR-330-3p hsa-miR-548n
SwitchGear 3'UTR luciferase reporter plasmidOTOR 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for OTOR
Predesigned siRNA for gene silencing in human, mouse, rat OTOR
Clone
Products:
     
OriGene clones in human, mouse for OTOR (see all 6)
OriGene ORF clones in mouse, rat for OTOR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: OTOR (NM_020157)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOR
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for OTOR
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTOR
  QuantiTect SYBR Green Assays in human, mouse, rat OTOR
  QuantiFast Probe-based Assays in human, mouse, rat OTOR

Additional mRNA sequence: 

AF233261.1 AF243505.1 AJ242552.1 AY359082.1 BC101688.1 BC101690.1 

4 DOTS entries:

DT.307722  DT.100844264  DT.92070627  DT.40239237 

Selected AceView cDNA sequences (see all 33):

AF233261 CR624240 N68117 AJ242552 NM_020157 BX444840 N69775 AY359082 
N63222 BI492218 BX418941 BE858557 AF243505 BI495576 BI495574 AW022083 
BX444839 BI496734 BI493008 N67179 BI493047 H88081 AW023201 BI494247 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for OTOR    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:              -     -                     
SP2:                                          


ECgene alternative splicing isoforms for OTOR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OTOR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGTTTTCTA
OTOR Expression
About this image


OTOR expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Pre-Granulosa Cells Primordial Follicle
 
 Limb (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
 
 Neurons
         Type1 Off Cone Bipolar Cells Inner Nuclear Layer
 
 Bone (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
 
 Eye (Sensory Organs)
         Type1 Off Cone Bipolar Cells Inner Nuclear Layer
OTOR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OTOR Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.41119

UniProtKB/Swiss-Prot: OTOR_HUMAN, Q9NRC9
Tissue specificity: Highly expressed in cochlea

    Custom PCR Arrays for OTOR
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTOR
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QuantiFast Probe-based Assays in human, mouse, rat OTOR
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OTOR gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Otor1 , 5 otoraplin1, 5 84.11(n)1
86.72(a)1
  2 (70.89 cM)5
573291  NM_020595.21  NP_065620.11 
 1430784735 
chicken
(Gallus gallus)
Aves OTOR1 otoraplin 72.58(n)
75(a)
  395484  NM_204732.1  NP_990063.1 
lizard
(Anolis carolinensis)
Reptilia OTOR6
otoraplin
58(a)
1 ↔ 1
1(127296933-127299461)
tropical clawed frog
(Xenopus tropicalis)
Amphibia otor1 otoraplin 69.67(n)
68.47(a)
  100487704  XM_002931743.2  XP_002931789.1 
zebrafish
(Danio rerio)
Actinopterygii mia26
melanoma inhibitory activity 2
11(a)
many ↔ many
17(12942953-12946866) ENSDARG00000078023


ENSEMBL Gene Tree for OTOR (if available)
TreeFam Gene Tree for OTOR (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OTOR gene
MIA-RAB4B2  MIA2  
4 SIMAP similar genes for OTOR using alignment to 1 protein entry:     OTOR_HUMAN:
MIA    MIA3    MIA2    CTAGE5

Find genes that share paralogs with OTOR           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OTOR (see all 178)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs61112681,2
H--16727248(+) CTTTAG/AGAcag 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
rs1926647391,2
--16727257(+) AGGTGC/TGGTGG 1 -- us2k10--------
rs1495080561,2
C--16727458(+) CCTGGA/CGACAG 1 -- us2k10--------
rs61358731,2
C,F,A,H--16727808(+) TCACAC/TACACA 1 -- us2k110Minor allele frequency- T:0.19NS EA NA CSA WA 718
rs61358741,2
C,F,A--16727809(+) CACACA/GCACAC 1 -- us2k16Minor allele frequency- G:0.24NA CSA WA EA 364
rs1841455781,2
--16727810(+) ACACAA/CACACA 1 -- us2k10--------
rs61358751,2
C,F,A,H--16727859(+) TTACCC/AATTTA 1 -- us2k1105Minor allele frequency- A:0.27NS EA NA PA EU CA WA CSA 6083
rs10184241,2
C,F,O,A,H--16727996(-) ATGCCC/TTCTCC 1 -- us2k121Minor allele frequency- G:0.02EA NA NS WA CSA 1078
rs1878852511,2
C--16728004(+) CATCCG/TGAGAG 1 -- us2k10--------
rs37612941,2
C,F,A,H--16728029(-) ATCCAT/CTGCTT 1 -- us2k128Minor allele frequency- C:0.17NS EA NA CSA WA 2910

HapMap Linkage Disequilibrium report for OTOR (16729003 - 16750707 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OTOR:    About this table    
Variant IDTypeSubtypePubMed ID
dgv90n6CNV Loss16902084

Human Gene Mutation Database (HGMD): OTOR
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OTOR
DNA2.0 Custom Variant and Variant Library Synthesis for OTOR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606067    OMIM disorders: --

1 disease for OTOR:    
About MalaCards
melanoma


Find genes that share disorders with OTOR           About GenesLikeMe

1 Novoseek inferred disease relationship for OTOR gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma 43 6 11161796 (2), 10873378 (1)

Genetic Association Database (GAD): OTOR
Human Genome Epidemiology (HuGE) Navigator: OTOR (2 documents)

Export disorders for OTOR gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OTOR gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with OTOR)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. (PubMed id 10873378)1, 2, 3, 9 Robertson N.G.... Morton C.C. (Genomics 2000)
  2. Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation. (PubMed id 11161796)1, 2, 9 Rendtorff N.D.... Tommerup N. (Genomics 2001)
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
  8. Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme. (PubMed id 10998416)1, 2 Cohen-Salmon M.... Petit C. (J. Biol. Chem. 2000)
  9. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. (PubMed id 23726511)1 Xie P....Gelernter J. (Biol. Psychiatry 2013)
  10. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)4 Elks C.E....Murray A. (Nat. Genet. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56914 HGNC: 8517 AceView: OTOR Ensembl:ENSG00000125879 euGenes: HUgn56914
ECgene: OTOR H-InvDB: OTOR

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OTOR Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for OTOR Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OTOR gene:
Search GeneIP for patents involving OTOR

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
 Antibodies for OTOR (Otoraplin/OTOR)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OTOR  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OTOR  
 OriGene MassSpec something-or-other for OTOR   OriGene clones in human, mouse for OTOR  
 OriGene qSTAR qPCR primer pairs in human, mouse for OTOR   OriGene Purified Protein for OTOR  
 OriGene ORF clones in mouse, rat for OTOR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for OTOR   OriGene Custom Protein Services for OTOR  

 
 
 Block miRNA regulation of human, mouse, rat OTOR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OTOR
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTOR Predesigned siRNA for gene silencing in human, mouse, rat OTOR
 QuantiFast Probe-based Assays in human, mouse, rat OTOR QuantiTect SYBR Green Assays in human, mouse, rat OTOR
 Custom PCR Arrays for OTOR Search Chromatin IP Primers for OTOR
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTOR  Search GeneGlobe Interaction Network for OTOR
 Regulatory tfbs in OTOR promoter
 GenScript Purified and Recombinant Proteins for OTOR GenScript cDNA clones with any tag delivered in your preferred vector for OTOR
 GenScript Custom Assay Services for OTOR GenScript Custom overexpressing Cell Line Services for OTOR
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for OTOR
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for OTOR
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 OTOR antibodies
 OTOR proteins
 OTOR lysates
 Antibodies for OTOR
 See all of Abcam's Antibodies, Kits and Proteins for OTOR
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for OTOR
 Proteins for OTOR
 Antibodies for OTOR
 ELISAs for OTOR
 CLIAs for OTOR



 Browse ESI BIO Cell Lines and PureStem Progenitors for OTOR
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOR
 SwitchGear 3'UTR luciferase reporter plasmids for OTOR
 SwitchGear Promoter luciferase reporter plasmids for OTOR
 ThermoFisher Antibodies for OTOR
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOR
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTOR
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OTOR
 Search LSBio for Antibodies for OTOR
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for OTOR
  Search eBioscience for proteins for OTOR
  Search eBioscience for elisas for OTOR
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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