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Aliases for OTOR Gene

Aliases for OTOR Gene

  • Otoraplin 2 3
  • Melanoma Inhibitory Activity-Like Protein 3 4
  • Fibrocyte-Derived Protein 3 4
  • FDP 3 4
  • MIAL1 3
  • MIAL 4

External Ids for OTOR Gene

Previous GeneCards Identifiers for OTOR Gene

  • GC20P016717
  • GC20P016724
  • GC20P016677

Summaries for OTOR Gene

Entrez Gene Summary for OTOR Gene

  • This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. [provided by RefSeq, Jul 2013]

GeneCards Summary for OTOR Gene

OTOR (Otoraplin) is a Protein Coding gene. Diseases associated with OTOR include melanoma. An important paralog of this gene is MIA-RAB4B.

Gene Wiki entry for OTOR Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTOR Gene

Genomics for OTOR Gene

Regulatory Elements for OTOR Gene

Genomic Location for OTOR Gene

Start:
16,748,353 bp from pter
End:
16,770,062 bp from pter
Size:
21,710 bases
Orientation:
Plus strand

Genomic View for OTOR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTOR Gene

Proteins for OTOR Gene

  • Protein details for OTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC9-OTOR_HUMAN
    Recommended name:
    Otoraplin
    Protein Accession:
    Q9NRC9
    Secondary Accessions:
    • D3DW22
    • Q3MIU6

    Protein attributes for OTOR Gene

    Size:
    128 amino acids
    Molecular mass:
    14332 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTOR Gene

Proteomics data for OTOR Gene at MOPED

Post-translational modifications for OTOR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTOR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTOR Gene

Domains for OTOR Gene

Protein Domains for OTOR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRC9

UniProtKB/Swiss-Prot:

OTOR_HUMAN :
  • Q9NRC9
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with OTOR: view

No data available for Gene Families for OTOR Gene

Function for OTOR Gene

Gene Ontology (GO) - Molecular Function for OTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OTOR: view

miRNA for OTOR Gene

miRTarBase miRNAs that target OTOR

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OTOR Gene

Localization for OTOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTOR Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTOR Gene COMPARTMENTS Subcellular localization image for OTOR gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OTOR: view

Pathways for OTOR Gene

SuperPathways for OTOR Gene

No Data Available

Interacting Proteins for OTOR Gene

Gene Ontology (GO) - Biological Process for OTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0007605 sensory perception of sound TAS 10873378
genes like me logo Genes that share ontologies with OTOR: view

No data available for Pathways by source for OTOR Gene

Transcripts for OTOR Gene

mRNA/cDNA for OTOR Gene

Unigene Clusters for OTOR Gene

Otoraplin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTOR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2:

Relevant External Links for OTOR Gene

GeneLoc Exon Structure for
OTOR
ECgene alternative splicing isoforms for
OTOR

Expression for OTOR Gene

mRNA expression in normal human tissues for OTOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OTOR Gene

This gene is overexpressed in Brain - Substantia nigra (18.8) and Stomach (4.8).

SOURCE GeneReport for Unigene cluster for OTOR Gene Hs.41119

mRNA Expression by UniProt/SwissProt for OTOR Gene

Q9NRC9-OTOR_HUMAN
Tissue specificity: Highly expressed in cochlea
genes like me logo Genes that share expressions with OTOR: view

No data available for Protein expression for OTOR Gene

Orthologs for OTOR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTOR 35
  • 100 (n)
  • 100 (a)
OTOR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTOR 35
  • 88.8 (n)
  • 89.06 (a)
OTOR 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTOR 35
  • 87.5 (n)
  • 90.62 (a)
OTOR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otor 35
  • 84.11 (n)
  • 86.72 (a)
Otor 16
Otor 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OTOR 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otor 35
  • 83.85 (n)
  • 86.72 (a)
chicken
(Gallus gallus)
Aves OTOR 35
  • 72.58 (n)
  • 75 (a)
OTOR 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTOR 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otor 35
  • 69.67 (n)
  • 68.47 (a)
zebrafish
(Danio rerio)
Actinopterygii mia2 36
  • 11 (a)
ManyToMany
Species with no ortholog for OTOR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTOR Gene

ENSEMBL:
Gene Tree for OTOR (if available)
TreeFam:
Gene Tree for OTOR (if available)

Paralogs for OTOR Gene

Paralogs for OTOR Gene

Selected SIMAP similar genes for OTOR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTOR: view

Variants for OTOR Gene

Sequence variations from dbSNP and Humsavar for OTOR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1018424 -- 16,747,351(-) ATGCC(C/T)TCTCC upstream-variant-2KB
rs1024183 -- 16,752,612(-) TGGGG(C/G/T)TGCTG downstream-variant-500B
rs1024184 -- 16,751,625(-) AGGCA(A/T)CAAAT utr-variant-3-prime, downstream-variant-500B
rs2092471 -- 16,750,321(+) AATGC(A/C)TACAT intron-variant
rs2143510 -- 16,747,842(+) ATCAA(C/T)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTOR Gene

Variant ID Type Subtype PubMed ID
dgv90n6 CNV Loss 16902084

Relevant External Links for OTOR Gene

HapMap Linkage Disequilibrium report
OTOR
Human Gene Mutation Database (HGMD)
OTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTOR Gene

Disorders for OTOR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OTOR Gene including...

Search for OTOR Gene in MalaCards »

(1) Novoseek inferred disease relationships for OTOR Gene

Disease -log(P) Hits PubMed IDs
melanoma 43 3

Relevant External Links for OTOR

Genetic Association Database (GAD)
OTOR
Human Genome Epidemiology (HuGE) Navigator
OTOR
genes like me logo Genes that share disorders with OTOR: view

No data available for UniProtKB/Swiss-Prot for OTOR Gene

Publications for OTOR Gene

  1. A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. (PMID: 10873378) Robertson N.G. … Morton C.C. (Genomics 2000) 2 3 4 23
  2. Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation. (PMID: 11161796) Rendtorff N.D. … Tommerup N. (Genomics 2001) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OTOR Gene

Sources for OTOR Gene

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