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Aliases for OTOR Gene

Aliases for OTOR Gene

  • Otoraplin 2 3 3 5
  • Melanoma Inhibitory Activity-Like Protein 3 4
  • Fibrocyte-Derived Protein 3 4
  • FDP 3 4
  • MIAL1 3
  • MIAL 4

External Ids for OTOR Gene

Previous GeneCards Identifiers for OTOR Gene

  • GC20P016717
  • GC20P016724
  • GC20P016677

Summaries for OTOR Gene

Entrez Gene Summary for OTOR Gene

  • This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. [provided by RefSeq, Jul 2013]

GeneCards Summary for OTOR Gene

OTOR (Otoraplin) is a Protein Coding gene. An important paralog of this gene is MIA.

Gene Wiki entry for OTOR Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTOR Gene

Genomics for OTOR Gene

Regulatory Elements for OTOR Gene

Enhancers for OTOR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OTOR on UCSC Golden Path with GeneCards custom track

Genomic Location for OTOR Gene

16,748,353 bp from pter
16,770,062 bp from pter
21,710 bases
Plus strand

Genomic View for OTOR Gene

Genes around OTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTOR Gene

Proteins for OTOR Gene

  • Protein details for OTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DW22
    • Q3MIU6

    Protein attributes for OTOR Gene

    128 amino acids
    Molecular mass:
    14332 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTOR Gene

Post-translational modifications for OTOR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTOR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTOR Gene

Domains & Families for OTOR Gene

Gene Families for OTOR Gene

Protein Domains for OTOR Gene


Suggested Antigen Peptide Sequences for OTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with OTOR: view

Function for OTOR Gene

genes like me logo Genes that share phenotypes with OTOR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OTOR

CRISPR Products

miRNA for OTOR Gene

miRTarBase miRNAs that target OTOR

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTOR Gene

Localization for OTOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTOR Gene


Subcellular locations from

Jensen Localization Image for OTOR Gene COMPARTMENTS Subcellular localization image for OTOR gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for OTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OTOR: view

Pathways & Interactions for OTOR Gene

SuperPathways for OTOR Gene

No Data Available

Interacting Proteins for OTOR Gene

Selected Interacting proteins: Q9NRC9-OTOR_HUMAN for OTOR Gene via IID

Gene Ontology (GO) - Biological Process for OTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0007605 sensory perception of sound TAS 10873378
genes like me logo Genes that share ontologies with OTOR: view

No data available for Pathways by source and SIGNOR curated interactions for OTOR Gene

Drugs & Compounds for OTOR Gene

No Compound Related Data Available

Transcripts for OTOR Gene

mRNA/cDNA for OTOR Gene

Unigene Clusters for OTOR Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTOR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -

Relevant External Links for OTOR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTOR Gene

mRNA expression in normal human tissues for OTOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OTOR Gene

This gene is overexpressed in Brain - Substantia nigra (x18.8) and Stomach (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of OTOR Gene:


SOURCE GeneReport for Unigene cluster for OTOR Gene:


mRNA Expression by UniProt/SwissProt for OTOR Gene:

Tissue specificity: Highly expressed in cochlea.
genes like me logo Genes that share expression patterns with OTOR: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OTOR Gene

Orthologs for OTOR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTOR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OTOR 34
  • 88.8 (n)
  • 89.06 (a)
  • 88 (a)
(Canis familiaris)
Mammalia OTOR 34
  • 87.5 (n)
  • 90.62 (a)
  • 90 (a)
(Mus musculus)
Mammalia Otor 34
  • 84.11 (n)
  • 86.72 (a)
Otor 16
Otor 35
  • 87 (a)
(Pan troglodytes)
Mammalia OTOR 34
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Otor 34
  • 83.85 (n)
  • 86.72 (a)
(Monodelphis domestica)
Mammalia OTOR 35
  • 80 (a)
(Gallus gallus)
Aves OTOR 34
  • 72.58 (n)
  • 75 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia OTOR 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia otor 34
  • 69.67 (n)
  • 68.47 (a)
(Danio rerio)
Actinopterygii mia2 35
  • 11 (a)
Species where no ortholog for OTOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTOR Gene

Gene Tree for OTOR (if available)
Gene Tree for OTOR (if available)

Paralogs for OTOR Gene

Paralogs for OTOR Gene

(4) SIMAP similar genes for OTOR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTOR: view

Variants for OTOR Gene

Sequence variations from dbSNP and Humsavar for OTOR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6135876 - 16,748,493(+) GAAGC(C/T)CTGTG reference, missense
rs1018424 -- 16,747,351(-) ATGCC(C/T)TCTCC upstream-variant-2KB
rs1024183 -- 16,752,612(-) TGGGG(C/G/T)TGCTG downstream-variant-500B
rs1024184 -- 16,751,625(-) AGGCA(A/T)CAAAT downstream-variant-500B, utr-variant-3-prime
rs2143510 -- 16,747,842(+) ATCAA(C/T)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OTOR Gene

Variant ID Type Subtype PubMed ID
dgv90n6 CNV deletion 16902084

Variation tolerance for OTOR Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OTOR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTOR Gene

Disorders for OTOR Gene

Relevant External Links for OTOR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OTOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTOR Gene

Publications for OTOR Gene

  1. A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. (PMID: 10873378) Robertson N.G. … Morton C.C. (Genomics 2000) 2 3 4 22 65
  2. Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation. (PMID: 11161796) Rendtorff N.D. … Tommerup N. (Genomics 2001) 3 4 22 65
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 65
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for OTOR Gene

Sources for OTOR Gene

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