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Aliases for OTOP3 Gene

Aliases for OTOP3 Gene

  • Otopetrin 3 2 3
  • Otopetrin-3 3

External Ids for OTOP3 Gene

Previous GeneCards Identifiers for OTOP3 Gene

  • GC17P073396
  • GC17P073529
  • GC17P070443
  • GC17P072931
  • GC17P068342

Summaries for OTOP3 Gene

GeneCards Summary for OTOP3 Gene

OTOP3 (Otopetrin 3) is a Protein Coding gene. An important paralog of this gene is OTOP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTOP3 Gene

Genomics for OTOP3 Gene

Regulatory Elements for OTOP3 Gene

Genomic Location for OTOP3 Gene

Start:
74,935,719 bp from pter
End:
74,949,992 bp from pter
Size:
14,274 bases
Orientation:
Plus strand

Genomic View for OTOP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OTOP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTOP3 Gene

Proteins for OTOP3 Gene

  • Protein details for OTOP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTS5-OTOP3_HUMAN
    Recommended name:
    Otopetrin-3
    Protein Accession:
    Q7RTS5
    Secondary Accessions:

    Protein attributes for OTOP3 Gene

    Size:
    596 amino acids
    Molecular mass:
    66296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTOP3 Gene

Proteomics data for OTOP3 Gene at MOPED

Post-translational modifications for OTOP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTOP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTOP3 Gene

Domains for OTOP3 Gene

Protein Domains for OTOP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTOP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTS5

UniProtKB/Swiss-Prot:

OTOP3_HUMAN :
  • Q7RTS5
Family:
  • Belongs to the otopetrin family.
genes like me logo Genes that share domains with OTOP3: view

No data available for Gene Families for OTOP3 Gene

Function for OTOP3 Gene

Gene Ontology (GO) - Molecular Function for OTOP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OTOP3: view

Phenotypes for OTOP3 Gene

MGI mutant phenotypes for OTOP3:
inferred from 1 alleles
GenomeRNAi human phenotypes for OTOP3:
genes like me logo Genes that share phenotypes with OTOP3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OTOP3 Gene

Localization for OTOP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTOP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTOP3 Gene COMPARTMENTS Subcellular localization image for OTOP3 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OTOP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OTOP3: view

Pathways for OTOP3 Gene

SuperPathways for OTOP3 Gene

No Data Available

Interacting Proteins for OTOP3 Gene

Gene Ontology (GO) - Biological Process for OTOP3 Gene

None

No data available for Pathways by source for OTOP3 Gene

Transcripts for OTOP3 Gene

mRNA/cDNA for OTOP3 Gene

(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTOP3 Gene

Otopetrin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTOP3 Gene

No ASD Table

Relevant External Links for OTOP3 Gene

GeneLoc Exon Structure for
OTOP3
ECgene alternative splicing isoforms for
OTOP3

Expression for OTOP3 Gene

mRNA expression in normal human tissues for OTOP3 Gene

mRNA differential expression in normal tissues according to GTEx for OTOP3 Gene

This gene is overexpressed in Esophagus - Mucosa (36.7) and Skin - Sun Exposed (Lower leg) (4.5).

SOURCE GeneReport for Unigene cluster for OTOP3 Gene Hs.454407

genes like me logo Genes that share expressions with OTOP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OTOP3 Gene

Orthologs for OTOP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OTOP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTOP3 35
  • 98.22 (n)
  • 97.52 (a)
OTOP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTOP3 35
  • 83.7 (n)
  • 82.06 (a)
OTOP3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTOP3 35
  • 87.16 (n)
  • 85.81 (a)
OTOP3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Otop3 35
  • 82.5 (n)
  • 83.04 (a)
Otop3 16
Otop3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OTOP3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTOP3 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otop3 35
  • 82.74 (n)
  • 83.39 (a)
chicken
(Gallus gallus)
Aves OTOP3 35
  • 69.22 (n)
  • 62.99 (a)
OTOP3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTOP3 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731580 35
  • 56.42 (n)
  • 46.62 (a)
Species with no ortholog for OTOP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OTOP3 Gene

ENSEMBL:
Gene Tree for OTOP3 (if available)
TreeFam:
Gene Tree for OTOP3 (if available)

Paralogs for OTOP3 Gene

Paralogs for OTOP3 Gene

Selected SIMAP similar genes for OTOP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OTOP3: view

Variants for OTOP3 Gene

Sequence variations from dbSNP and Humsavar for OTOP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1388511 -- 74,939,714(-) CTGGC(A/T)TAACG intron-variant
rs1388512 -- 74,939,710(-) CATAA(C/T)GTAGG intron-variant
rs1491766 -- 74,938,110(-) TTTCC(C/T)ACTCC intron-variant
rs1542752 - 74,942,005(-) GACAG(A/G)GAAGA missense, reference
rs1873599 -- 74,940,918(-) AATGT(C/T)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTOP3 Gene

Variant ID Type Subtype PubMed ID
nsv518292 CNV Loss 19592680
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
nsv457909 CNV Gain 19166990
nsv470601 CNV Loss 18288195
dgv3255n71 CNV Loss 21882294
nsv908752 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Relevant External Links for OTOP3 Gene

HapMap Linkage Disequilibrium report
OTOP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTOP3 Gene

Disorders for OTOP3 Gene

(1) University of Copenhagen DISEASES for OTOP3 Gene

genes like me logo Genes that share disorders with OTOP3: view

No data available for UniProtKB/Swiss-Prot for OTOP3 Gene

Publications for OTOP3 Gene

  1. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. (PMID: 12651873) Hurle B. … Ornitz D.M. (Hum. Mol. Genet. 2003) 2 3 4
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OTOP3 Gene

Sources for OTOP3 Gene

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