OTOP2 Gene
protein-coding GIFtS: 45
GCID: GC17P072922
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otopetrin 2
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Aliases
for OTOP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Otopetrin 21 2 | | Otopetrin-21 |
Export aliases for OTOP2 gene to outside databasesPrevious GC identifers: GC17P073384 GC17P073517 GC17P070431 GC17P068330 |
Summaries
for OTOP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for OTOP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OTOP2 gene promoter:
Nkx5-1 C/EBPalpha CHOP-10 CREB deltaCREB FOXO1a ZID Pax-4a FOXO1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for OTOP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.3OTOP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P072922: view genomic region
(about GC identifiers)
Start:
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72,920,370 bp from pter |
End:
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72,930,007 bp from pter |
Size:
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9,638 bases |
Orientation:
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plus strand |
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Proteins
for OTOP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OTOP2_HUMAN, Q7RTS6 (See
protein sequence)Recommended Name: Otopetrin-2 Size: 562 amino acids; 62236 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for OTOP2: NX_Q7RTS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7RTS6
OTOP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_835454.1
ENSEMBL proteins: ENSP00000463837 ENSP00000332528
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
OTOP2 for ontologies About GeneDecksing
OTOP2 Antibody Products:
Assay Products for OTOP2: |
Protein
Domains /
Families
for OTOP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OTOP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7RTS6ProtoNet protein and cluster: Q7RTS6 UniProtKB/Swiss-Prot: OTOP2_HUMAN, Q7RTS6Similarity: Belongs to the otopetrin family |
Function
for OTOP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OTOP2 (NM_178160) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTOP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOP2 |
|
Pathways & Interactions
for OTOP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTOP2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/44 Interacting proteins for OTOP2 (Q7RTS62 ENSP000003325284) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
|
Drugs & Compounds
for OTOP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OTOP2
Search CenterWatch for drugs/clinical trials and news about OTOP2
|
Transcripts
for OTOP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OTOP2 gene: NM_178160.2 Unigene Cluster for OTOP2: Otopetrin 2 Hs.352515 [show with all ESTs]Unigene Representative Sequence: NM_1781603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000584711(uc002jmf.1) ENST00000580223 ENST00000331427(uc010wrp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OTOP2 (NM_178160) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OTOP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOP2 |
Additional cDNA sequence: AK000063.1 2 DOTS entries: DT.97823595 DT.120908063 7 AceView cDNA sequences: BK000567 NM_178160 AW155641 BI828712 AK000063 BM466860 BQ326836
GeneLoc Exon Structure
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Expression
for OTOP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OTOP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACGCTGTGT
About this image
See OTOP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OTOP2
SOURCE GeneReport for Unigene cluster: Hs.352515
SABiosciences Custom PCR Arrays for OTOP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTOP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTOP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOP2 |
Orthologs
for OTOP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OTOP2 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for OTOP2 (if available)
TreeFam Gene Tree for OTOP2 (if available) |
Paralogs
for OTOP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OTOP2 gene
- OTOP12 OTOP32
2 SIMAP similar genes for OTOP2 using alignment to 1 protein entry: OTOP2_HUMAN:OTOP3 OTOP1
OTOP2 for paralogs About GeneDecksing
|
Genomic Variants
for OTOP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OTOP2 (72920370 - 72930007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OTOP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTOP2 |
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Disorders
/ Diseases
for OTOP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OTOP2 for disorders About GeneDecksing
OMIM gene information: 607827
OMIM disorders: --
2  diseases for OTOP2: About MalaCardsvestibular disease usher syndrome
1 disease from the University of Copenhagen DISEASES database for OTOP2:Usher syndrome Export disorders for OTOP2 gene to outside databases
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Publications
for OTOP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OTOP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OTOP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. (PubMed id 12651873)1, 2, 3 Hurle B.... Ornitz D.M. (2003)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
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External Searches for OTOP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing OTOP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OTOP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OTOP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OTOP2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for OTOP2 gene:
Search GeneIP for patents involving OTOP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OTOP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OTOP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OTOP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OTOP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OTOP2 | | OriGene 3'-UTR Clone for OTOP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OTOP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OTOP2 | | OriGene Custom Protein Services for OTOP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OTOP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTOP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTOP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOP2 |
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| | | | Search Tocris compounds for OTOP2 |
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 | | | OTOP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for OTOP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOP2 |
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