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Aliases for OTOP2 Gene

Aliases for OTOP2 Gene

  • Otopetrin 2 2 3 5

External Ids for OTOP2 Gene

Previous GeneCards Identifiers for OTOP2 Gene

  • GC17P073384
  • GC17P073517
  • GC17P070431
  • GC17P072922
  • GC17P068330

Summaries for OTOP2 Gene

GeneCards Summary for OTOP2 Gene

OTOP2 (Otopetrin 2) is a Protein Coding gene. An important paralog of this gene is OTOP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTOP2 Gene

Genomics for OTOP2 Gene

Regulatory Elements for OTOP2 Gene

Enhancers for OTOP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OTOP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OTOP2 Gene

Chromosome:
17
Start:
74,922,963 bp from pter
End:
74,933,913 bp from pter
Size:
10,951 bases
Orientation:
Plus strand

Genomic View for OTOP2 Gene

Genes around OTOP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTOP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTOP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTOP2 Gene

Proteins for OTOP2 Gene

  • Protein details for OTOP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTS6-OTOP2_HUMAN
    Recommended name:
    Otopetrin-2
    Protein Accession:
    Q7RTS6

    Protein attributes for OTOP2 Gene

    Size:
    562 amino acids
    Molecular mass:
    62236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTOP2 Gene

Proteomics data for OTOP2 Gene at MOPED

Post-translational modifications for OTOP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTOP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTOP2 Gene

Domains & Families for OTOP2 Gene

Protein Domains for OTOP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTOP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTS6

UniProtKB/Swiss-Prot:

OTOP2_HUMAN :
  • Belongs to the otopetrin family.
Family:
  • Belongs to the otopetrin family.
genes like me logo Genes that share domains with OTOP2: view

No data available for Gene Families for OTOP2 Gene

Function for OTOP2 Gene

Phenotypes for OTOP2 Gene

GenomeRNAi human phenotypes for OTOP2:
genes like me logo Genes that share phenotypes with OTOP2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OTOP2 Gene

Localization for OTOP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTOP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OTOP2 Gene COMPARTMENTS Subcellular localization image for OTOP2 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for OTOP2 Gene

Pathways & Interactions for OTOP2 Gene

SuperPathways for OTOP2 Gene

No Data Available

Interacting Proteins for OTOP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332528%0d%0a9606.ENSP00000220592%0d%0a
Selected Interacting proteins: Q7RTS6-OTOP2_HUMAN ENSP00000332528 for OTOP2 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for OTOP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OTOP2 Gene

Drugs & Compounds for OTOP2 Gene

No Compound Related Data Available

Transcripts for OTOP2 Gene

mRNA/cDNA for OTOP2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTOP2 Gene

Otopetrin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OTOP2 Gene

No ASD Table

Relevant External Links for OTOP2 Gene

GeneLoc Exon Structure for
OTOP2
ECgene alternative splicing isoforms for
OTOP2

Expression for OTOP2 Gene

mRNA expression in normal human tissues for OTOP2 Gene

mRNA differential expression in normal tissues according to GTEx for OTOP2 Gene

This gene is overexpressed in Colon - Transverse (x35.4) and Testis (x8.4).

Protein differential expression in normal tissues from HIPED for OTOP2 Gene

This gene is overexpressed in Platelet (54.9) and Placenta (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OTOP2 Gene



SOURCE GeneReport for Unigene cluster for OTOP2 Gene Hs.352515

genes like me logo Genes that share expression patterns with OTOP2: view

Protein tissue co-expression partners for OTOP2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OTOP2 Gene

Orthologs for OTOP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OTOP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OTOP2 35
  • 87.34 (n)
  • 87.17 (a)
OTOP2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OTOP2 35
  • 87.05 (n)
  • 86.81 (a)
mouse
(Mus musculus)
Mammalia Otop2 35
  • 83.63 (n)
  • 85.23 (a)
Otop2 16
Otop2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OTOP2 35
  • 98.65 (n)
  • 98.07 (a)
OTOP2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Otop2 35
  • 83.81 (n)
  • 84.52 (a)
oppossum
(Monodelphis domestica)
Mammalia OTOP2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OTOP2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves OTOP2 35
  • 66.24 (n)
  • 62.43 (a)
OTOP2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTOP2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496174 35
  • 59.61 (n)
  • 54.25 (a)
zebrafish
(Danio rerio)
Actinopterygii otop2 35
  • 57.18 (n)
  • 47.76 (a)
otop2 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42265 35
  • 46.77 (n)
  • 30.49 (a)
Species with no ortholog for OTOP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTOP2 Gene

ENSEMBL:
Gene Tree for OTOP2 (if available)
TreeFam:
Gene Tree for OTOP2 (if available)

Paralogs for OTOP2 Gene

Paralogs for OTOP2 Gene

(2) SIMAP similar genes for OTOP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTOP2: view

Variants for OTOP2 Gene

Sequence variations from dbSNP and Humsavar for OTOP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_037760 A colorectal cancer sample
rs6501741 - 74,931,028(+) ACCCC(A/C/G/T)GGCTG reference, missense
rs572191 -- 74,931,838(-) GCTGA(A/G)ATTAT intron-variant
rs572415 -- 74,931,768(-) accct(G/T)ttggc intron-variant
rs2460856 -- 74,927,345(-) AAAGC(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OTOP2 Gene

Variant ID Type Subtype PubMed ID
nsv518292 CNV Loss 19592680
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
nsv457909 CNV Gain 19166990
nsv470601 CNV Loss 18288195
dgv3255n71 CNV Loss 21882294

Variation tolerance for OTOP2 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OTOP2 Gene

Disorders for OTOP2 Gene

Relevant External Links for OTOP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OTOP2

No disorders were found for OTOP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTOP2 Gene

Publications for OTOP2 Gene

  1. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. (PMID: 12651873) Hurle B. … Ornitz D.M. (Hum. Mol. Genet. 2003) 2 3 4 67

Products for OTOP2 Gene

Sources for OTOP2 Gene

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