OTOG Gene
protein-coding GIFtS: 39
GCID: GC11P017530
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otogelin
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Aliases
for OTOG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Otogelin1 | | OTGN1 2 3 5 | | Mlemp1 | | FLJ463461 | | DFNB18B2 |
Export aliases for OTOG gene to outside databasesPrevious GC identifers: GC11U990096 GC11P017534 GC11P017537 GC11P017252 |
Summaries
for OTOG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0Function: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of theotoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organizationand/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role inmechanotransduction processes (By similarity)
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Genomic Views
for OTOG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018922.1 NC_000011.9 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OTOG gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OTOG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p14.3OTOG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P017530: view genomic region
(about GC identifiers)
Start:
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17,568,920 bp from pter |
End:
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17,668,697 bp from pter |
Size:
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99,778 bases |
Orientation:
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plus strand |
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Proteins
for OTOG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0 (See
protein sequence)Recommended Name: Otogelin precursor Size: 2925 amino acids; 314794 Da
Subcellular location: Apical cell membrane; Peripheral membrane protein; Extracellular side (By similarity). Secreted,extracellular space (By similarity). Note=Found in fiber-like structures during the maturation process of thetectorial membrane (By similarity)
Secondary accessions: A8MTX6 A8MUJ0 B7WPC4Alternative splicing: 2 isoforms: Q6ZRI0-1 Q6ZRI0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OTOG: NX_Q6ZRI0
Post-translational modifications:
N-glycosylated (By similarity). Not O-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZRI0
OTOG Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000382329 ENSP00000399057 ENSP00000341666 ENSP00000382323
Human Recombinant Protein Products for OTOG:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
OTOG for ontologies About GeneDecksing
OTOG Antibody Products:
Assay Products for OTOG: |
Protein
Domains /
Families
for OTOG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OTOG for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6ZRI0ProtoNet protein and cluster: Q6ZRI0 1 Blocks protein family: IPB002919 Trypsin inhibitor-like
UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0Similarity: Belongs to the otogelin familySimilarity: Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 TIL (trypsin inhibitory-like) domainSimilarity: Contains 4 VWFD domains |
Function
for OTOG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OTOG_HUMAN, Q6ZRI0Function: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of theotoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organizationand/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role inmechanotransduction processes (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0046556 | alpha-N-arabinofuranosidase activity |
IEA | -- |
OTOG for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for OTOG:
3 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Otog):
OTOG for phenotypes About GeneDecksing
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOG |
|
Pathways & Interactions
for OTOG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OTOG
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007605 | sensory perception of sound |
IEA | -- | | GO:0008344 | adult locomotory behavior |
IEA | -- | | GO:0046373 | L-arabinose metabolic process |
IEA | -- |
OTOG for ontologies About GeneDecksing
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Drugs & Compounds
for OTOG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OTOG
Search CenterWatch for drugs/clinical trials and news about OTOG 
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Transcripts
for OTOG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OTOG gene: NM_198497.1 Unigene Cluster for OTOG: Otogelin Hs.688380 [show with all ESTs]Unigene Representative Sequence: XM_2918166 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399397 ENST00000498332 ENST00000428619 ENST00000485669 ENST00000342528(uc001mnh.1)
ENST00000399391
Additional cDNA sequence: AK128214.1 XM_291816.8 4 DOTS entries: DT.120725444 DT.101972486 DT.120725443 DT.120749884 2 AceView cDNA sequences: AK128214 BV173919
GeneLoc Exon Structure
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Expression
for OTOG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OTOG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OTOG Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.688380
SABiosciences Custom PCR Arrays for OTOG
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OTOG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOG |
Orthologs
for OTOG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OTOG gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for OTOG (if available)
TreeFam Gene Tree for OTOG (if available) |
Paralogs
for OTOG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OTOG gene
- MUC5AC2 TECTA2 MUC22 OTOGL2 MUC62 MUC5B2 MUC192 FCGBP2
- VWF2 BMPER2
2 SIMAP similar genes for OTOG using alignment to 3 protein entries: OTOG_HUMAN (see all proteins):OTOGL MUC5AC
OTOG for paralogs About GeneDecksing
|
Genomic Variants
for OTOG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OTOG (17568920 - 17668697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OTOG: --
Human Gene Mutation Database (HGMD): OTOG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTOG |
|
Disorders
/ Diseases
for OTOG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OTOG for disorders About GeneDecksing
OMIM gene information: 604487
OMIM disorders: --
2  diseases for OTOG: About MalaCardsautosomal recessive nonsyndromic deafness nonsyndromic deafness
1 disease from the University of Copenhagen DISEASES database for OTOG:Nonsyndromic deafness Export disorders for OTOG gene to outside databases
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Publications
for OTOG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OTOG gene integrated from 9 sources:
(articles sorted by number of sources associating them with OTOG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Otogelin: a glycoprotein specific to the acellular membranes of the inner ear. (PubMed id 9405633)1, 3 Cohen-Salmon M....Petit C. (1997)
- Targeted disruption of otog results in deafness and severe imbalance. (PubMed id 10655058)1, 9 Simmler M.C....Panthier J.J. (2000)
- Mapping of the otogelin gene (OTGN) to mouse chromosome 7 and human chromosome 11p14.3: a candidate for human autosomal recessive nonsyndromic deafness DFNB18. (PubMed id 10337628)1, 9 Cohen-Salmon M....Petit C. (1999)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Twister mutant mice are defective for otogelin, a component specific to inner ear acellular membranes. (PubMed id 11063250)9 Simmler M.C....Panthier J.J. (2000)
- Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene. (PubMed id 18452040)9 Moreno-Pelayo M.A....Richardson G.P. (2008)
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External Searches for OTOG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing OTOG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OTOG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OTOG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OTOG | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for OTOG gene:
Search GeneIP for patents involving OTOG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OTOG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OTOG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OTOG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OTOG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OTOG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OTOG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OTOG |
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| | | | Search Tocris compounds for OTOG |
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 | | | OTOG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOG |
|  |  |  |  | | | | Search ThermoFisher Antibodies for OTOG |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OTOG |
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