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OTOG Gene

protein-coding   GIFtS: 38
GCID: GC11P017530

Otogelin

  See OTOG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
otogelin1 2
OTGN2 3 5
DFNB18B2 5
MLEMP2

External Ids:    HGNC: 85161   Entrez Gene: 3409902   Ensembl: ENSG000001881627   OMIM: 6044875   UniProtKB: Q6ZRI03   

Export aliases for OTOG gene to outside databases

Previous GC identifers: GC11U990096 GC11P017534 GC11P017537 GC11P017252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTOG Gene:
The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the
orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in
fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and
likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness,
type 18B. (provided by RefSeq, Mar 2013)

GeneCards Summary for OTOG Gene:
OTOG (otogelin) is a protein-coding gene. Diseases associated with OTOG include deafness, autosomal recessive 18b, and deafness, autosomal recessive 76. GO annotations related to this gene include alpha-L-arabinofuranosidase activity and structural molecule activity. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0
Function: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the
otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the
organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea.
May play a role in mechanotransduction processes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OTOG gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OTOG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p14.3

OTOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTOG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P017530:  view genomic region     (about GC identifiers)

Start:
17,568,920 bp from pter      End:
17,668,697 bp from pter
Size:
99,778 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0 (See protein sequence)
Recommended Name: Otogelin precursor  
Size: 2925 amino acids; 314794 Da
Secondary accessions: A8MTX6 A8MUJ0 B7WPC4
Alternative splicing: 2 isoforms:  Q6ZRI0-1   Q6ZRI0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTOG: NX_Q6ZRI0

Explore proteomics data for OTOG at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity). Not O-glycosylated (By similarity)1
  • Glycosylation2 at Asn914, Asn1478, Asn1612
  • Modification sites at PhosphoSitePlus

  • See OTOG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001264198.1  
    ENSEMBL proteins: 
     ENSP00000382329   ENSP00000399057   ENSP00000341666   ENSP00000382323  

    OTOG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for OTOG

     
    Search eBioscience for Proteins for OTOG 

    OTOG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. Antibodies for OTOG
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    OTOG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OTOG
    Cloud-Clone Corp. CLIAs for OTOG
    Search eBioscience for ELISAs for OTOG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR007934 AbfB
     IPR000742 EG-like_dom
     IPR006207 Cys_knot_C
     IPR002919 TIL_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZRI0

    ProtoNet protein and cluster: Q6ZRI0

    1 Blocks protein domain: IPB002919 Trypsin inhibitor-like

    UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0
    Similarity: Belongs to the otogelin family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
    Similarity: Contains 4 VWFD domains


    Find genes that share domains with OTOG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTOG_HUMAN, Q6ZRI0
    Function: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the
    otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the
    organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea.
    May play a role in mechanotransduction processes (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0046556alpha-L-arabinofuranosidase activity IEA--
         
    Find genes that share ontologies with OTOG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OTOG:
     Decreased number of cells in m 

         3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Otog):
     behavior/neurological  hearing/vestibular/ear  reproductive system 

    Find genes that share phenotypes with OTOG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTOG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OTOG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTOG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTOG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OTOG_HUMAN, Q6ZRI0: Apical cell membrane; Peripheral membrane protein; Extracellular side (By similarity).
    Secreted, extracellular space (By similarity). Note=Found in fiber-like structures during the maturation process
    of the tectorial membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol2
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005829cytosol IEA--
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with OTOG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTOG
    Interactions:

        Search GeneGlobe Interaction Network for OTOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for OTOG (ENSP000003823234) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAPBPLENSP000002665564STRING: ENSP00000266556
    GOPCENSP000003574844STRING: ENSP00000357484
    DCLK1ENSP000002554484STRING: ENSP00000255448
    DCLK2ENSP000002965504STRING: ENSP00000296550
    SCRT1ENSP000003316924STRING: ENSP00000331692
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0046373L-arabinose metabolic process IEA--

    Find genes that share ontologies with OTOG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTOG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OTOG gene (2 alternative transcripts): 
    NM_001277269.1  NM_198497.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399397 ENST00000498332 ENST00000428619 ENST00000485669 ENST00000342528(uc001mnh.1)
    ENST00000399391
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OTOG (NM_173591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OTOG
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTOG
      QuantiTect SYBR Green Assays in human, mouse, rat OTOG
      QuantiFast Probe-based Assays in human, mouse, rat OTOG

    2 AceView cDNA sequences:

    AK128214 BV173919 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OTOG Expression
    About this image

    OTOG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTOG Protein Expression
        Custom PCR Arrays for OTOG
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OTOG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otog1 , 5 otogelin1, 5 83.59(n)1
    83.1(a)1
      7 (29.66 cM)5
    184191  NM_013624.21  NP_038652.21 
     462409875 
    chicken
    (Gallus gallus)
    Aves OTOG1 otogelin 57.3(n)
    54.25(a)
      423075  XM_421007.4  XP_421007.4 
    lizard
    (Anolis carolinensis)
    Reptilia OTOG6
    otogelin
    51(a)
    1 ↔ 1
    1(66982664-67095580)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347532 Xenopus laevis transcribed sequence with weak similarity more 74.97(n)    CB180339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii OTOG6
    otogelin
    45(a)
    1 ↔ 1
    7(40856645-40925487) ENSDARG00000068460


    ENSEMBL Gene Tree for OTOG (if available)
    TreeFam Gene Tree for OTOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTOG gene
    MUC5AC2  ZAN2  TECTA2  MUC22  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    2 SIMAP similar genes for OTOG using alignment to 3 protein entries:     OTOG_HUMAN (see all proteins):
    OTOGL    MUC5AC

    Find genes that share paralogs with OTOG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTOG (see all 2167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692504
    Deafness, autosomal recessive, 18B (DFNB18B)4--see VAR_0692502 P L mis40--------
    rs38344551,2
    C--17251825(-) ATTCA-/TTCA  
            
    CTCAA
    1 -- us2k11Minor allele frequency- TTCA:0.50CSA 2
    rs2015465771,2
    C--17251828(+) AGTGAA/GTNNNN 2 -- us2k10--------
    rs106882131,2
    C--17260971(+) GGGCAGAG/-GAGAt 2 -- cds11Minor allele frequency- -:0.50CSA 2
    rs723841551,2
    C--17265674(+) GAGGG-/AGGA  
            
    AGGAA
    2 -- int10--------
    rs744634871,2
    C--17283151(+) GTGGG-/ATGGGGG 2 -- int10--------
    rs611935731,2
    --17283152(+) TGGGAG/TGGGGG 2 -- int10--------
    rs750232121,2
    C,F--17491142(+) ATTTGG/ATCAGC 2 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1457145131,2
    C--17491199(+) AACCAA/GGCCTG 2 -- us2k10--------
    rs20735821,2
    C,F,A,H--17491260(-) TCATCC/TCTTTC 2 -- us2k124Minor allele frequency- T:0.35EA NS NA WA CSA 3086

    HapMap Linkage Disequilibrium report for OTOG (17568920 - 17668697 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OTOG: --
    Human Gene Mutation Database (HGMD): OTOG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTOG
    DNA2.0 Custom Variant and Variant Library Synthesis for OTOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604487   
    OMIM disorders: 614945  
    UniProtKB/Swiss-Prot: OTOG_HUMAN, Q6ZRI0
  • Deafness, autosomal recessive, 18B (DFNB18B) [MIM:614945]: A form of non-syndromic deafness characterized
    by a moderate hearing impairment, which can be associated with vestibular dysfunction, and a flat to shallow "U"
    or slightly downsloping shaped audiograms. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 4 diseases for OTOG:    
    About MalaCards
    deafness, autosomal recessive 18b    deafness, autosomal recessive 76    nonsyndromic deafness    autosomal recessive nonsyndromic deafness

    1 disease from the University of Copenhagen DISEASES database for OTOG:
    Nonsyndromic deafness

    Find genes that share disorders with OTOG           About GenesLikeMe

    Genetic Association Database (GAD): OTOG

    Export disorders for OTOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTOG gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with OTOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of the gene encoding otogelin are a cause of autosomal- recessive nonsyndromic moderate hearing impairment. (PubMed id 23122587)1, 2 Schraders M.... Kremer H. (Am. J. Hum. Genet. 2012)
    2. Otogelin: a glycoprotein specific to the acellular membranes of the inner ear. (PubMed id 9405633)1, 3 Cohen-Salmon M....Petit C. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Targeted disruption of otog results in deafness and severe imbalance. (PubMed id 10655058)1, 9 Simmler M.C....Panthier J.J. (Nat. Genet. 2000)
    4. Mapping of the otogelin gene (OTGN) to mouse chromosome 7 and human chromosome 11p14.3: a candidate for human autosomal recessive nonsyndromic deafness DFNB18. (PubMed id 10337628)1, 9 Cohen-Salmon M....Petit C. (Mamm. Genome 1999)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. (PubMed id 17434096)4 MatarA-n M....Meschia J.F. (Lancet Neurol 2007)
    7. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (Lancet Neurol 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340990 HGNC: 8516 AceView: OTOG Ensembl:ENSG00000188162 euGenes: HUgn340990
    ECgene: OTOG H-InvDB: OTOG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTOG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTOG gene:
    Search GeneIP for patents involving OTOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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