Aliases for OTOA Gene
External Ids for OTOA Gene
Previous HGNC Symbols for OTOA Gene
Previous GeneCards Identifiers for OTOA Gene
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for OTOA Gene
OTOA (Otoancorin) is a Protein Coding gene. Diseases associated with OTOA include Deafness, Autosomal Recessive 22 and Nonsyndromic Hearing Loss And Deafness. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is STRC.
UniProtKB/Swiss-Prot for OTOA Gene
May act as an adhesion molecule.