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OTOA Gene

protein-coding   GIFtS: 47
GCID: GC16P021689

Otoancorin

(Previous names: deafness, autosomal recessive 22)
(Previous symbol: DFNB22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
otoancorin1 2
DFNB221 2 5
Cancer/Testis Antigen 1081 2
Deafness, Autosomal Recessive 221
CT1082

External Ids:    HGNC: 163781   Entrez Gene: 1461832   Ensembl: ENSG000001557197   OMIM: 6070385   UniProtKB: Q7RTW83   

Export aliases for OTOA gene to outside databases

Previous GC identifers: GC16P021150 GC16P021698 GC16P021656 GC16P021597 GC16P020071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OTOA Gene:
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface
between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed
that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the
underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22
(DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2009)

GeneCards Summary for OTOA Gene:
OTOA (otoancorin) is a protein-coding gene. Diseases associated with OTOA include dfnb22 nonsyndromic hearing loss and deafness, and papillary transitional carcinoma. An important paralog of this gene is STRC.

UniProtKB/Swiss-Prot: OTOAN_HUMAN, Q7RTW8
Function: May act as an adhesion molecule




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OTOA gene promoter:
         Pax-5   Pax-6   RREB-1   HSF1 (long)   CUTL1   GATA-1   HSF2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OTOA promoter sequence
   Search Chromatin IP Primers for OTOA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OTOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2|16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

OTOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OTOA gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P021689:  view genomic region     (about GC identifiers)

Start:
21,689,835 bp from pter      End:
21,772,050 bp from pter
Size:
82,216 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OTOAN_HUMAN, Q7RTW8 (See protein sequence)
Recommended Name: Otoancorin precursor  
Size: 1153 amino acids; 128533 Da
Sequence caution: Sequence=AK057335; Type=Frameshift; Positions=1139;
Secondary accessions: A1L3A8 A2VDI0 B3KWU3 E9PF51 Q8NA86 Q96M76
Alternative splicing: 5 isoforms:  Q7RTW8-1   Q7RTW8-2   Q7RTW8-3   Q7RTW8-4   Q7RTW8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OTOA: NX_Q7RTW8

Explore proteomics data for OTOA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156, Asn211, Asn244, Asn289, Asn321, Asn394, Asn398, Asn460, Asn544, Asn812,
                                 Asn911, Asn974
  • Modification sites at PhosphoSitePlus

  • See OTOA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001155155.1  NP_653273.3  NP_733764.1  

    ENSEMBL proteins: 
     ENSP00000286149   ENSP00000373610   ENSP00000373608   ENSP00000373609  

    OTOA Human Recombinant Protein Products:

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    Novus Biologicals OTOA Protein
    Novus Biologicals OTOA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OTOA

    OTOA Antibody Products:

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    Abcam antibodies for OTOA
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    Search ThermoFisher Antibodies for OTOA
    LSBio Antibodies in human, mouse, rat for OTOA

    OTOA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for OTOA
    Cloud-Clone Corp. CLIAs for OTOA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026663 Otoancorin
     IPR026664 Stereocilin_related

    Graphical View of Domain Structure for InterPro Entry Q7RTW8

    ProtoNet protein and cluster: Q7RTW8

    UniProtKB/Swiss-Prot: OTOAN_HUMAN, Q7RTW8
    Similarity: Belongs to the stereocilin family


    OTOA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTOAN_HUMAN, Q7RTW8
    Function: May act as an adhesion molecule

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Otoa):

     hearing/vestibular/ear  nervous system 

    OTOA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OTOA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OTOA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OTOA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OTOA

    miRNA
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    Block miRNA regulation of human, mouse, rat OTOA using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OTOA:
    hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidOTOA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OTOA
    Predesigned siRNA for gene silencing in human, mouse, rat OTOA

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for OTOA

    Clone
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    OriGene clones in human, mouse for OTOA (see all 17)
    OriGene ORF clones in mouse, rat for OTOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OTOA (NM_144672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOA

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OTOAN_HUMAN, Q7RTW8: Apical cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (Probable). Secreted,
    extracellular space, extracellular matrix (Probable). Note=At the interface between the apical surface of the
    epithelia and the overlying acellular gel of the tectorial and otoconial membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    OTOA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OTOA
    Interactions:

        Search GeneGlobe Interaction Network for OTOA

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion IEA--
    GO:0007605sensory perception of sound IEA--
    GO:0019226transmission of nerve impulse IEA--

    OTOA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OTOA (OTOAN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OTOA gene (3 alternative transcripts): 
    NM_001161683.1  NM_144672.3  NM_170664.2  

    Unigene Cluster for OTOA:

    Otoancorin
    Hs.408336  [show with all ESTs]
    Unigene Representative Sequence: NM_144672
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286149 ENST00000388958(uc002djh.3) ENST00000388956(uc010vbj.2)
    ENST00000388957(uc002dji.3) ENST00000569064 ENST00000563871(uc010vbk.2)
    ENST00000563506
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OTOA using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OTOA:
    hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidOTOA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OTOA
    Predesigned siRNA for gene silencing in human, mouse, rat OTOA
    Clone
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    OriGene ORF clones in mouse, rat for OTOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OTOA (NM_144672)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OTOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OTOA
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OTOA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OTOA
      QuantiTect SYBR Green Assays in human, mouse, rat OTOA
      QuantiFast Probe-based Assays in human, mouse, rat OTOA

    Additional mRNA sequence: 

    AK093062.1 AK125840.1 AK302733.1 BC038458.1 BC129992.1 BC129993.1 

    6 DOTS entries:

    DT.100019525  DT.101982055  DT.100019526  DT.97817379  DT.99936814  DT.95358409 

    20 AceView cDNA sequences:

    AK093062 AX747895 NM_144672 NM_170664 BK000099 AK125840 BV176563 BG177023 
    BC038458 BC040551 BI459722 AI300783 BG216075 BI561486 BM455441 AK057335 
    BG105996 BG219824 AI867309 BG184449 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OTOA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                      -     -                                         -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                            -                                                               
    SP4:                                                                                                                                                            

    ExUns: 26
    SP1:      
    SP2:      
    SP3:      
    SP4:      


    ECgene alternative splicing isoforms for OTOA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OTOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGAGACA
    OTOA Expression
    About this image


    OTOA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    OTOA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OTOA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408336
        Custom PCR Arrays for OTOA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OTOA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OTOA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Otoa1 , 5 otoancorin1, 5 81.4(n)1
    77.38(a)1
      7 (65.07 cM)5
    2461901  NM_139310.11  NP_647471.11 
     1210833225 
    chicken
    (Gallus gallus)
    Aves OTOA1 otoancorin 63.31(n)
    58.5(a)
      416624  XM_001234948.3  XP_001234949.3 
    lizard
    (Anolis carolinensis)
    Reptilia OTOA6
    otoancorin
    54(a)
    1 ↔ 1
    GL343507.1(41276-71152)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia otoa1 otoancorin 58.12(n)
    50.55(a)
      100490578  XM_002931980.2  XP_002932026.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000070151 otoancorin-like 42.85(n)
    27.94(a)
      100007015  XM_001345550.4  XP_001345586.4 


    ENSEMBL Gene Tree for OTOA (if available)
    TreeFam Gene Tree for OTOA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OTOA gene
    STRC2  

    OTOA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OTOA
    PGOHUM00000249020


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OTOA (see all 1666)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681841031,2
    C--20077828(+) TATTA-/TTA   
      TTATTT
    TTTAG
    2 -- int10--------
    rs30541881,2
    C--20099176(-) CTTTT-/CTGTTCT 3 -- int1 trp30--------
    rs3702441361,2
    C--20105764(+) AAAAA-/AAAAAA 3 -- int10--------
    rs20056151,2
    --20107382(-) GGAAGA/GAAGAA 3 -- int10--------
    rs28876211,2
    C--20107410(-) GAAAGA/GAAGGA 3 -- int11Minor allele frequency- G:0.00NA 2
    rs30541641,2
    C--20107446(-) agaga-/AAgaagg 3 -- int10--------
    rs58161591,2
    C--20107564(+) TTCCTC/TTCCCT 3 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs2018303351,2
    --20115142(+) AATAC-/AAAAAA 3 -- int10--------
    rs346435951,2
    C--20115157(+) ACCCCA/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs679201121,2
    F--20115157(+) ACCCCC/AAAAAA 3 -- int11Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for OTOA (21689835 - 21772050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OTOA (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714070CNV Deletion23290073
    nsv820589CNV Duplication20802225
    dgv48n16CNV Insertion17901297
    dgv348n27CNV Loss19166990
    dgv2n29CNV Loss16826518
    nsv471086CNV Loss18288195
    dgv2644n71CNV Loss21882294
    dgv116e55CNV Loss17911159
    dgv2642n71CNV Loss21882294
    esv2751552CNV Loss17911159

    Human Gene Mutation Database (HGMD): OTOA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OTOA
    DNA2.0 Custom Variant and Variant Library Synthesis for OTOA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607038   
    OMIM disorders: 607039  
    UniProtKB/Swiss-Prot: OTOAN_HUMAN, Q7RTW8
  • Deafness, autosomal recessive, 22 (DFNB22) [MIM:607039]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 10 diseases for OTOA:    
    About MalaCards
    dfnb22 nonsyndromic hearing loss and deafness    papillary transitional carcinoma    deafness, autosomal recessive 22    nonsyndromic hearing loss and deafness, autosomal recessive
    deafness, autosomal recessive 76    deafness and hereditary hearing loss    nonsyndromic hearing loss and deafness    sensorineural hearing loss
    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for OTOA:
    Papillary transitional carcinoma

    OTOA for disorders           About GeneDecksing

    Genetic Association Database (GAD): OTOA
    Human Genome Epidemiology (HuGE) Navigator: OTOA (1 document)

    Export disorders for OTOA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OTOA gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with OTOA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. (PubMed id 11972037)1, 2, 3 Zwaenepoel I.... Petit C. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genome-wide analysis of cancer/testis gene expression. (PubMed id 19088187)1, 3 Hofmann O....Hide W. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. (PubMed id 19888295)1, 9 Shahin H....Kanaan M. (Eur. J. Hum. Genet. 2010)
    6. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PubMed id 19139490)2 Jia W.... Qian X.H. (Mol. Cell. Proteomics 2009)
    7. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PubMed id 18057069)4 Cronin S....Hardiman O. (Hum. Mol. Genet. 2008)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146183 HGNC: 16378 AceView: OTOA Ensembl:ENSG00000155719 euGenes: HUgn146183
    ECgene: OTOA H-InvDB: OTOA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OTOA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OTOA gene:
    Search GeneIP for patents involving OTOA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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