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OTC Gene

protein-coding GIFtS: 60

GC0XP038096

ornithine carbamoyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.1.3.3 ^³
MGC129967 ^²
MGC129968 ^²
MGC138856 ^²
OCTD ^²
OTCase ^³
OTTHUMP00000024343 ^²

Descriptions
Ornithine transcarbamylase ^², ³
ornithine carbamoyltransferase ^²

External Ids
HGNC: 8512¹
Entrez Gene: 5009²
UniProtKB: P00480³
Ensembl: ENSG00000036473⁷

Search outside databases for aliases for OTC gene

Previous GC identifers: GC0XP036316 GC0XP036498 GC0XP037053 GC0XP037242 GC0XP037967

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OTC:

This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift

mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes

hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy,

it may play a role in that disease also. [provided by RefSeq]

Gene Wiki entry for OTC (Ornithine_transcarbamylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OTC gene

Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp21.1

OTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP038096: (about GC identifiers)

Start:	38,096,680 bp from pter
End:	38,165,650 bp from pter
Size:	68,971 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OTC_HUMAN, P00480 (See protein sequence)

Recommended Name: Ornithine carbamoyltransferase, mitochondrial precursor

Size: 354 amino acids; 39935 Da

Subunit: Homotrimer

Subcellular location: Mitochondrion matrix

PDB structures from and Proteopedia :

1C9Y (3D)

1EP9 (3D)

1FVO (3D)

1OTH (3D)

Secondary accessions: Q3KNR1 Q6B0I1 Q9NYJ5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000522.3

ENSEMBL proteins:

ENSP00000039007

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ornithine Carbamoyltransferase)
	Human Recombinant Proteins from Abnova (OTC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005759	mitochondrial matrix	NAS	6372096
GO:0009348	ornithine carbamoyltransferase complex	NAS	--

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Antibodies for OTC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OTC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ornithine Carbamoyltransferase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OTC

Assays for OTC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P00480

ProtoNet protein and cluster: P00480

1 Blocks protein family: IPB002292 Ornithine carbamoyltransferase signature

UniProtKB/Swiss-Prot: OTC_HUMAN, P00480

Similarity: Belongs to the ATCase/OTCase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OTC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000531

Applied Biosystems Silencer® siRNAs for OTC

Sigma-Aldrich siRNA and siRNA Panels for OTC

Sigma-Aldrich shRNA for OTC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000531
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000531
untagged cDNA clone in CMV expression vector: NM_000531

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000531

UniProtKB/Swiss-Prot: OTC_HUMAN, P00480

Catalytic activity: Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Enzyme Number (IUBMB): EC 2.1.3.3

Genatlas biochemistry entry for OTC:

ornithine carbamoyltransferase,ornithine metabolism,urea cycle,mitochondrial matrix

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Otc):

growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
life span-post-weaning/aging	skin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004585	ornithine carbamoyltransferase activity	NAS	--
GO:0005543	phospholipid binding	IEA	--
GO:0016597	amino acid binding	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0042301	phosphate binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for OTC (Your Favorite Gene powered by Ingenuity)

Urea Cycle and Metabolism of Amino Groups
Arginine and Proline Metabolism

GeneDecks OTC for the pathways selected above

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UniProtKB/Swiss-Prot: OTC_HUMAN, P00480

Pathway: Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate:

step 1/1

5/22 Interacting proteins for OTC (ENSP00000039007³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASS1	ENSP00000361471³	STRING (score=.999)
ASL	ENSP00000307188³	STRING (score=.994)
OAT	ENSP00000357838³	STRING (score=.994)
ARG1	ENSP00000349446³	STRING (score=.991)
ARG2	ENSP00000261783³	STRING (score=.991)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000050	urea cycle	NAS	--
GO:0006526	arginine biosynthetic process	NAS	--
GO:0008652	amino acid biosynthetic process	IEA	--
GO:0051259	protein oligomerization	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OTC
10/33 Novoseek chemical compound relationships for OTC gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine	97.54	977	1549234 (6), 2342523 (6), 14607061 (5), 7499756 (5) (see all 99)
carbamoyl phosphate	90.90	77	10813810 (3), 11388595 (3), 9540805 (2), 1720458 (2) (see all 42)
orotidine	85.23	5	2342523 (2), 10388475 (2), 11117427 (1)
urea	76.11	83	17098461 (3), 15050979 (2), 10946359 (2), 11276280 (2) (see all 46)
norvaline	69.72	7	10813810 (2), 18062991 (1), 11237854 (1)
n-acetylglutamate	68.40	6	2342831 (1), 2208834 (1), 15164414 (1), 1313366 (1) (see all 5)
phaseolotoxin	65.90	2	8407821 (1), 10357851 (1)
n-acetylornithine	59.84	2	15731101 (2)
mspi	56.30	5	1353535 (1), 9427144 (1), 7860064 (1), 1806371 (1) (see all 5)
ammonium	45.58	4	8464164 (1), 19318352 (1), 16774619 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OTC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000531

Sigma-Aldrich siRNA and siRNA Panels for OTC

Sigma-Aldrich shRNA for OTC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000531

REFSEQ mRNAs for OTC gene:

NM_000531.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000531

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000531
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000531
                                 untagged cDNA clone in CMV expression vector: NM_000531

Additional cDNA sequence:

AK292757.1 BC074745.2 BC107153.1 BC107154.1 BC114496.1 K02100.1

2 DOTS entries:

DT.410164 DT.91668489

13 AceView cDNA sequences:

BX118743 AA677307 AI032960 BX494966 CB158478 NM_000531 BC074745 AV682105

AA463601 BX496295 K02100 AA677326 AI023397

highest scoring ESTs for OTC:

K02100 AA677307 AA677326 AI023397 AI032960 AI247721 BX494966 BC074745 BG197188 BG198056

Unigene Cluster for OTC:

Ornithine carbamoyltransferase

Hs.117050 [show with all ESTs]

Unigene Representative Sequence: NM_000531

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000039007

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OTC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OTC

¹ / ² / ³

4 probe-sets matching OTC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
683_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.31	K02100	1.00	1.00	1.00	1
35111_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.78	K02100	1.00	1.00	1.00	1
207200_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000531	0.60	1.00	0.82	1
207200_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OTC for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTCCCTGC

SOURCE GeneReport for Unigene cluster: Hs.117050
Expression variation in blood from EXPOLDB for OTC
UniProtKB/Swiss-Prot: OTC_HUMAN, P00480
Tissue specificity: Mainly in liver and intestinal mucosa

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OTC gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OTC¹	--	ornithine carbamoyltransferase	93.5(n) 96.89(a)	480878 XM_537995.2 XP_537995.1
cow (Bos taurus)	OTC¹	--	ornithine carbamoyltransferase	92.56(n) 94.92(a)	280887 NM_177487.2 NP_803453.1
rat (Rattus norvegicus)	Otc¹	--	ornithine carbamoyltransferase	88.79(n) 91.81(a)	25611 NM_013078.1 NP_037210.1
mouse (Mus musculus)	Otc^{1, 5}	X (3.00 cM)⁵	ornithine transcarbamylase^{1, 5}	88.98(n)¹ 92.66(a)¹	18416¹ NM_008769.3¹ NP_032795.1¹ AI265390⁵ AK050930⁵ (see all 18)
chicken (Gallus gallus)	OTC¹	--	ornithine carbamoyltransferase	75.05(n) 75.14(a)	395735 NM_204910.1 NP_990241.1

About this table Species with no ortholog for OTC

ENSEMBL Gene Tree for OTC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/587 NCBI SNPs in OTC are shown (see all 587 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1800321^1,2	A,C,F,H,O	38111547(+)	`TCTAAA/GAAACT`	1	K/R	mis¹		15		EU EA WA NA	951
	rs991916^1,2	A,C,F,H	38165845(+)	`ACTCCA/GAAGTT`	1	--	ng3¹		18		NA EA EU WA	1487
	rs991917^1,2	A,C,F,O	38165970(+)	`TAAAAC/GCATGG`	1	--	ng3¹		6		EA NA	396
	rs5963408^1,2	A,C,F,H	38095758(+)	`GTGCAA/GCTCGG`	1	--	ng5¹		8		EU EA WA	630
	rs5917573^1,2	A,C,F,H	38096535(+)	`CAGCCA/GGTACC`	1	--	ng5¹ ese³		4		EU EA WA	412
	rs4826994^1,2	C,F,H	38094841(+)	`TGCAGC/TTCCCC`	1	--	ng5¹ trp³		11		EU EA WA NA	752
--	rs5963409^1,2	A,C,F	38095913(+)	`CTGTCG/AGGTGC`	1	--	ng5¹		3		NA	142
--	rs5963412^1,2	A,C	38096233(+)	`gattaC/Taggcg`	1	--	ng5¹		0	--	--	--	--
	rs4827093^1,2	F,H	38094883(+)	`TTAACT/ATTTTT`	1	--	ng5¹ tfbs³		4		EU EA WA	386
--	rs5917572^1,2	C,F	38096453(+)	`TCAGGG/ACTGTC`	1	--	ng5¹ ese³		3		NA	115

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HapMap Linkage Disequilibrium images for OTC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 300461 disorders: 311250

UniProtKB/Swiss-Prot: OTC_HUMAN, P00480

Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD)

[MIM:311250]. OTCD is an X-linked disorder of the urea cycle which causes a form of

hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote

males by a very severe neonatal hyperammonemic coma that generally proves to be fatal.

Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after

protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet.

The arbitrary classification of patients into the "neonatal" group (clinical hyperammonemia in the

first few days of life) and "late" onset (clinical presentation after the neonatal period) has

been used to differentiate severe from mild forms

10/65 Novoseek disease relationships for OTC gene (see all 65 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine transcarbamylase deficiency	99.47	361	14607061 (5), 7797025 (4), 7499756 (4), 2208834 (4) (see all 99)
hyperammonemia	95.36	93	1549234 (4), 1742044 (2), 16575347 (2), 12777539 (2) (see all 64)
orotic aciduria	95.00	13	18440262 (1), 1456259 (1), 7499756 (1), 8938172 (1) (see all 11)
ornithine carbamoyltransferase deficiency disease	90.13	4	12974275 (1), 2298453 (1), 12974280 (1), 12974271 (1)
citrullinemia	84.56	18	18562231 (2), 10869432 (1), 11337324 (1), 19217439 (1) (see all 8)
argininosuccinate lyase deficiency	83.60	10	18616627 (2), 10869432 (1), 19217439 (1), 15164414 (1)
carbamoyl phosphate synthetase deficiency	80.65	3	1863104 (1), 1720458 (1), 15863597 (1)
aciduria argininosuccinic	75.55	5	18562231 (2), 11148551 (1), 7717428 (1)
enzyme deficiency	75.36	6	8464164 (1), 16774619 (1), 8099056 (1), 8677801 (1) (see all 5)
hyperargininemia	75.19	5	15798789 (1), 18033025 (1), 1404883 (1), 15164414 (1) (see all 5)

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Genatlas disease: OTC

neonatal distress and hyperammonemia,including late-onset hyperammonemic coma

Human Gene Mutation Database: OTC
Human Genome Epidemiology Navigator: OTC (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/376 PubMed articles for OTC gene (see all 376 ):

Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency. (PubMed id 10502831)^{1, 3, 4} Climent C.... Rubio V. (1999)
The ornithine transcarbamylase (OTC) gene: mutations in 50 Japanese families with OTC deficiency. (PubMed id 9286441)^{1, 3, 4} Matsuda I. and Tanase S. (1997)
Identification of new mutations in the ornithine transcarbamylase (OTC) gene in Korean families. (PubMed id 8830175)^{1, 3, 4} Yoo H.-W.... Lee D.-H. (1996)
Identification of seven novel missense mutations, two splice-site mutations, two microdeletions and a polymorphic amino acid substitution in the gene for ornithine transcarbamylase (OTC) in patients with OTC deficiency. (PubMed id 11793483)^{1, 3, 4} Climent C. and Rubio V. (2002)
Improved molecular diagnostics for ornithine transcarbamylase deficiency. (PubMed id 1671317)^{1, 3, 4} Grompe M.... Fenwick R.G. Jr. (1991)
Expression, purification and kinetic characterization of wild-type human ornithine transcarbamylase and a recurrent mutant that produces 'late onset' hyperammonaemia. (PubMed id 9065786)^{1, 3, 4} Morizono H.... Allewell N.M. (1997)
Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution. (PubMed id 10813810)^{1, 3, 4} Shi D.... Allewell N.M. (2000)
Identification of 'private' mutations in patients with ornithine transcarbamylase deficiency. (PubMed id 9266388)^{1, 3, 4} Tuchman M.... Allewell N.M. (1997)
Ornithine transcarbamylase deficiency: characterization of gene mutations and polymorphisms. (PubMed id 8956038)^{1, 3, 4} Leibundgut E.O.... Liechti-Gallati S. (1996)
A splicing mutation, a nonsense mutation (Y167X) and two missense mutations (I159T and A209V) in Spanish patients with ornithine transcarbamylase deficiency. (PubMed id 8530002)^{1, 3, 4} Garcia-Perez M.A....Rubio V. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5009	HGNC: 8512	AceView: OTC	Ensembl:ENSG00000036473	euGenes: HUgn5009
ECgene: OTC	H-InvDB: OTC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
OTC	http://63.75.201.100/otc/index.asp
GeneReviews	http://www.genetests.org/query?gene=OTC

Licensable Technologies for OTC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OTC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OTC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OTC		Antibodies for OTC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OTC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OTC)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Ornithine Carbamoyltransferase)
	Antibodies (Ornithine Carbamoyltransferase)

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Search Tocris compounds for OTC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OTC

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Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OTC Gene at Home site.
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OTC Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for OTC

Summaries
for OTC

Genomic Location
for OTC

Proteins
for OTC

Protein Domains/
Families
for OTC

Gene Function
for OTC

Pathways & Interactions
for OTC

Drugs & Compounds
for OTC

Transcripts
for OTC

Expression
for OTC

Orthologs
for OTC

Paralogs
for OTC

SNPs/Variants
for OTC

Disorders & Mutations
for OTC

Medical News
for OTC

Publications
for OTC

Search for OTC

Genome Databases showing OTC

Other Databases showing OTC

Specialized Databases showing OTC

Licensable Technologies
for OTC

Services
for OTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OTC Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor OTC

Summariesfor OTC

Genomic Locationfor OTC

Proteinsfor OTC

Protein Domains/Familiesfor OTC

Gene Functionfor OTC

Pathways & Interactionsfor OTC

Drugs & Compoundsfor OTC

Transcriptsfor OTC

Expression for OTC

Orthologsfor OTC

Paralogsfor OTC

SNPs/Variantsfor OTC

Disorders & Mutationsfor OTC

Medical Newsfor OTC

Publicationsfor OTC

Search for OTC

Genome Databases showing OTC

Other Databases showing OTC

Specialized Databases showing OTC

Licensable Technologiesfor OTC

Servicesfor OTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OTC

Summaries
for OTC

Genomic Location
for OTC

Proteins
for OTC

Protein Domains/
Families
for OTC

Gene Function
for OTC

Pathways & Interactions
for OTC

Drugs & Compounds
for OTC

Transcripts
for OTC

Expression
for OTC

Orthologs
for OTC

Paralogs
for OTC

SNPs/Variants
for OTC

Disorders & Mutations
for OTC

Medical News
for OTC

Publications
for OTC

Licensable Technologies
for OTC

Services
for OTC