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Aliases for OSTN Gene

Aliases for OSTN Gene

  • Osteocrin 2 3
  • MUSCLIN 3 4

External Ids for OSTN Gene

Previous GeneCards Identifiers for OSTN Gene

  • GC03U900494
  • GC03P192251
  • GC03P192413
  • GC03P190917
  • GC03P188329

Summaries for OSTN Gene

GeneCards Summary for OSTN Gene

OSTN (Osteocrin) is a Protein Coding gene. Diseases associated with OSTN include acromesomelic dysplasia. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for OSTN Gene

  • Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTN Gene

Genomics for OSTN Gene

Regulatory Elements for OSTN Gene

Genomic Location for OSTN Gene

Chromosome:
3
Start:
191,199,142 bp from pter
End:
191,265,615 bp from pter
Size:
66,474 bases
Orientation:
Plus strand

Genomic View for OSTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTN Gene

Proteins for OSTN Gene

  • Protein details for OSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61366-OSTN_HUMAN
    Recommended name:
    Osteocrin
    Protein Accession:
    P61366
    Secondary Accessions:
    • A1A4U3

    Protein attributes for OSTN Gene

    Size:
    133 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OSTN Gene

Proteomics data for OSTN Gene at MOPED

Post-translational modifications for OSTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OSTN Gene

Domains & Families for OSTN Gene

Protein Domains for OSTN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OSTN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OSTN Gene

Function for OSTN Gene

Molecular function for OSTN Gene

UniProtKB/Swiss-Prot Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

Gene Ontology (GO) - Molecular Function for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with OSTN: view

Phenotypes for OSTN Gene

genes like me logo Genes that share phenotypes with OSTN: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSTN Gene

Localization for OSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSTN Gene COMPARTMENTS Subcellular localization image for OSTN gene
Compartment Confidence
extracellular 2

Gene Ontology (GO) - Cellular Components for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OSTN: view

Pathways & Interactions for OSTN Gene

SuperPathways for OSTN Gene

No Data Available

Interacting Proteins for OSTN Gene

Gene Ontology (GO) - Biological Process for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0003416 endochondral bone growth IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0030154 cell differentiation IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Pathways by source and SIGNOR curated interactions for OSTN Gene

Drugs & Compounds for OSTN Gene

No Compound Related Data Available

Transcripts for OSTN Gene

mRNA/cDNA for OSTN Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTN Gene

No ASD Table

Relevant External Links for OSTN Gene

GeneLoc Exon Structure for
OSTN
ECgene alternative splicing isoforms for
OSTN

Expression for OSTN Gene

mRNA expression in normal human tissues for OSTN Gene

mRNA differential expression in normal tissues according to GTEx for OSTN Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x11.1) and Brain - Frontal Cortex (BA9) (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSTN Gene



SOURCE GeneReport for Unigene cluster for OSTN Gene Hs.526794

mRNA Expression by UniProt/SwissProt for OSTN Gene

P61366-OSTN_HUMAN
Tissue specificity: Expressed in bone
genes like me logo Genes that share expression patterns with OSTN: view

Protein tissue co-expression partners for OSTN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for OSTN Gene

Orthologs for OSTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSTN 35
  • 90.4 (n)
  • 92.42 (a)
OSTN 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSTN 35
  • 89.39 (n)
  • 90.15 (a)
OSTN 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ostn 35
  • 81.03 (n)
  • 76.92 (a)
Ostn 16
Ostn 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSTN 35
  • 99.5 (n)
  • 99.25 (a)
OSTN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ostn 35
  • 81.57 (n)
  • 78.03 (a)
oppossum
(Monodelphis domestica)
Mammalia OSTN 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves OSTN 35
  • 61.65 (n)
  • 58.65 (a)
OSTN 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ostn 35
  • 64.9 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333936 35
  • 55.74 (n)
  • 51.26 (a)
ostn 36
  • 46 (a)
OneToOne
Species with no ortholog for OSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTN Gene

ENSEMBL:
Gene Tree for OSTN (if available)
TreeFam:
Gene Tree for OSTN (if available)

Paralogs for OSTN Gene

No data available for Paralogs for OSTN Gene

Variants for OSTN Gene

Sequence variations from dbSNP and Humsavar for OSTN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1349921 -- 191,220,281(-) ATAAG(G/T)TATGG intron-variant
rs1454689 -- 191,263,383(-) CATGA(C/T)TGAAA downstream-variant-500B
rs1454692 -- 191,197,168(+) ACATC(A/T)CATTC upstream-variant-2KB
rs1551426 -- 191,211,580(+) aagca(C/T)ccaat upstream-variant-2KB, intron-variant
rs1551427 -- 191,211,758(+) TTGTC(C/T)CTTCA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTN Gene

Variant ID Type Subtype PubMed ID
essv7531 CNV CNV 17122850
dgv1544e1 CNV Complex 17122850
dgv5360n71 CNV Loss 21882294
nsv878101 CNV Loss 21882294
nsv878102 CNV Loss 21882294
nsv878104 CNV Loss 21882294
nsv428428 CNV Gain 18775914
esv2661473 CNV Deletion 23128226

Variation tolerance for OSTN Gene

Residual Variation Intolerance Score: 54.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSTN Gene

HapMap Linkage Disequilibrium report
OSTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTN Gene

Disorders for OSTN Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSTN Gene - From: DISEASES

Disorder Aliases PubMed IDs
acromesomelic dysplasia
  • acromesomelic dwarfism
- elite association
Search OSTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for OSTN

Genetic Association Database (GAD)
OSTN
Human Genome Epidemiology (HuGE) Navigator
OSTN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSTN
genes like me logo Genes that share disorders with OSTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSTN Gene

Publications for OSTN Gene

  1. Osteocrin--beyond just another bone protein? (PMID: 19234809) Moffatt P. … Thomas G.P. (Cell. Mol. Life Sci. 2009) 23 67
  2. Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide. (PMID: 19244276) Kita S. … Shimomura I. (J. Endocrinol. 2009) 23 67
  3. [Osteocrin is a new signaling molecule acting on bone]. (PMID: 18950569) Moffatt P. (Med Sci (Paris) 2008) 23 67
  4. Musclin gene expression is strongly related to fast-glycolytic phenotype. (PMID: 17189616) Banzet S. … Bigard A.X. (Biochem. Biophys. Res. Commun. 2007) 23 67
  5. Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. (PMID: 16291870) Potter L.R. … Dickey D.M. (Endocr. Rev. 2006) 23 67

Products for OSTN Gene

Sources for OSTN Gene

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