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Aliases for OSTN Gene

Aliases for OSTN Gene

  • Osteocrin 2 3 3 5
  • MUSCLIN 3 4

External Ids for OSTN Gene

Previous GeneCards Identifiers for OSTN Gene

  • GC03U900494
  • GC03P192251
  • GC03P192413
  • GC03P190917
  • GC03P188329

Summaries for OSTN Gene

GeneCards Summary for OSTN Gene

OSTN (Osteocrin) is a Protein Coding gene. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for OSTN Gene

  • Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTN Gene

Genomics for OSTN Gene

Regulatory Elements for OSTN Gene

Enhancers for OSTN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G191350 1.1 Ensembl ENCODE dbSUPER 9.5 +151.7 151659 0.8 ZNF362 JUN FEZF1 ZNF398 YY1 PRDM6 GLIS1 FOS PRDM1 PRDM4 CCDC50 UTS2B OSTN GC03P191372
GH03G190530 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.2 -665.7 -665678 5.5 FOXA2 ARID4B GATA2 FOS SP5 MIER2 PPARG MIER3 RCOR2 ETV4 IL1RAP OSTN CLDN1 GCNT1P3
GH03G191141 0.8 Ensembl ENCODE 10.1 -57.2 -57215 1.0 JUND JUN STAT3 FOS EP300 TCF7L2 OSTN CCDC50 GC03M191028
GH03G191364 0.7 dbSUPER 10 +169.6 169631 8.9 ZNF146 PKNOX1 JUN MAFG CEBPB DPF2 ZBTB40 ZNF316 GATA2 SCRT2 CCDC50 UTS2B OSTN GC03P191372
GH03G191069 0.7 ENCODE 9.4 -128.9 -128928 1.6 NFIB MAFG ZNF195 MNT ATF2 ZNF316 MAFF NFIC CREB1 FOS OSTN GC03M191028
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSTN on UCSC Golden Path with GeneCards custom track

Genomic Location for OSTN Gene

Chromosome:
3
Start:
191,199,142 bp from pter
End:
191,265,615 bp from pter
Size:
66,474 bases
Orientation:
Plus strand

Genomic View for OSTN Gene

Genes around OSTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTN Gene

Proteins for OSTN Gene

  • Protein details for OSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61366-OSTN_HUMAN
    Recommended name:
    Osteocrin
    Protein Accession:
    P61366
    Secondary Accessions:
    • A1A4U3

    Protein attributes for OSTN Gene

    Size:
    133 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    • Interacts with NPR3.

neXtProt entry for OSTN Gene

Post-translational modifications for OSTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTN Gene

No data available for DME Specific Peptides for OSTN Gene

Domains & Families for OSTN Gene

Protein Domains for OSTN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61366

UniProtKB/Swiss-Prot:

OSTN_HUMAN :
  • Belongs to the Osteocrin family.
Family:
  • Belongs to the Osteocrin family.
genes like me logo Genes that share domains with OSTN: view

No data available for Gene Families for OSTN Gene

Function for OSTN Gene

Molecular function for OSTN Gene

UniProtKB/Swiss-Prot Function:
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is induced in the developing cerebral cortex in response to neuronal activity in neurons: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).

Gene Ontology (GO) - Molecular Function for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with OSTN: view
genes like me logo Genes that share phenotypes with OSTN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OSTN

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSTN Gene

Localization for OSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSTN gene
Compartment Confidence
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OSTN: view

Pathways & Interactions for OSTN Gene

No Data Available

Interacting Proteins for OSTN Gene

Selected Interacting proteins: P61366-OSTN_HUMAN for OSTN Gene via IID

Symbol External ID(s) Details
FOXO1

Gene Ontology (GO) - Biological Process for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003416 endochondral bone growth IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Pathways by source and SIGNOR curated interactions for OSTN Gene

Drugs & Compounds for OSTN Gene

No Compound Related Data Available

Transcripts for OSTN Gene

mRNA/cDNA for OSTN Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTN Gene

No ASD Table

Relevant External Links for OSTN Gene

GeneLoc Exon Structure for
OSTN
ECgene alternative splicing isoforms for
OSTN

Expression for OSTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSTN Gene

mRNA differential expression in normal tissues according to GTEx for OSTN Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x11.1) and Brain - Frontal Cortex (BA9) (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSTN Gene



Protein tissue co-expression partners for OSTN Gene

NURSA nuclear receptor signaling pathways regulating expression of OSTN Gene:

OSTN

SOURCE GeneReport for Unigene cluster for OSTN Gene:

Hs.526794

mRNA Expression by UniProt/SwissProt for OSTN Gene:

P61366-OSTN_HUMAN
Tissue specificity: Enriched in neocortical regions of the developing cerebral cortex (PubMed:27830782). Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum (PubMed:27830782). Also expressed in bone (PubMed:14523025). In developing neonatal rib bone, present at high level in osteoblasts on bone-forming surfaces, in newly incorporated osteocytes and in some late hypertrophic chondrocytes (at protein level) (PubMed:15923362). In adult bone, localizes specifically to osteoblasts and young osteocytes at bone-forming sites (at protein level) (PubMed:15923362).

Evidence on tissue expression from TISSUES for OSTN Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with OSTN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSTN Gene

Orthologs for OSTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSTN 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia OSTN 34 35
  • 90.4 (n)
dog
(Canis familiaris)
Mammalia OSTN 34 35
  • 89.39 (n)
rat
(Rattus norvegicus)
Mammalia Ostn 34
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Ostn 34 16 35
  • 81.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OSTN 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSTN 34 35
  • 61.65 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ostn 34
  • 64.9 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333936 34
  • 55.74 (n)
ostn 35
  • 46 (a)
OneToOne
Species where no ortholog for OSTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTN Gene

ENSEMBL:
Gene Tree for OSTN (if available)
TreeFam:
Gene Tree for OSTN (if available)

Paralogs for OSTN Gene

No data available for Paralogs for OSTN Gene

Variants for OSTN Gene

Sequence variations from dbSNP and Humsavar for OSTN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000028041 -- 191,199,863(+) CCTGT(G/T)CTTCA intron-variant
rs1000031781 -- 191,218,191(+) TGATC(C/T)GTAAA intron-variant
rs1000159717 -- 191,205,165(+) GTGCT(A/G)TTTGT intron-variant, upstream-variant-2KB
rs1000161186 -- 191,235,664(+) ACTCT(A/C)TCATC intron-variant, upstream-variant-2KB
rs1000211684 -- 191,248,911(+) ACCAT(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTN Gene

Variant ID Type Subtype PubMed ID
esv2661473 CNV deletion 23128226
esv2759209 CNV gain+loss 17122850
esv3599089 CNV loss 21293372
esv3599090 CNV gain 21293372
esv3599091 CNV loss 21293372
esv3599092 CNV gain 21293372
esv3599094 CNV loss 21293372
nsv1012488 CNV loss 25217958
nsv428428 CNV gain 18775914
nsv997716 CNV loss 25217958

Variation tolerance for OSTN Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTN Gene

Disorders for OSTN Gene

Relevant External Links for OSTN

Genetic Association Database (GAD)
OSTN
Human Genome Epidemiology (HuGE) Navigator
OSTN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSTN

No disorders were found for OSTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTN Gene

Publications for OSTN Gene

  1. Characterization of osteocrin expression in human bone. (PMID: 15923362) Bord S. … Compston J.E. (J. Histochem. Cytochem. 2005) 3 4 22 64
  2. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. (PMID: 14523025) Thomas G. … Lanctot C. (J. Biol. Chem. 2003) 2 3 4 64
  3. Evolution of Osteocrin as an activity-regulated factor in the primate brain. (PMID: 27830782) Ataman B. … Greenberg M.E. (Nature 2016) 3 4 64
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  5. Musclin, a novel skeletal muscle-derived secretory factor. (PMID: 15044443) Nishizawa H. … Shimomura I. (J. Biol. Chem. 2004) 3 4 64

Products for OSTN Gene

Sources for OSTN Gene

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