Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSTN Gene

Aliases for OSTN Gene

  • Osteocrin 2 3 5
  • MUSCLIN 3 4

External Ids for OSTN Gene

Previous GeneCards Identifiers for OSTN Gene

  • GC03U900494
  • GC03P192251
  • GC03P192413
  • GC03P190917
  • GC03P188329

Summaries for OSTN Gene

GeneCards Summary for OSTN Gene

OSTN (Osteocrin) is a Protein Coding gene. Diseases associated with OSTN include Acromesomelic Dysplasia. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for OSTN Gene

  • Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTN Gene

Genomics for OSTN Gene

Regulatory Elements for OSTN Gene

Enhancers for OSTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSTN on UCSC Golden Path with GeneCards custom track

Genomic Location for OSTN Gene

191,199,142 bp from pter
191,265,615 bp from pter
66,474 bases
Plus strand

Genomic View for OSTN Gene

Genes around OSTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTN Gene

Proteins for OSTN Gene

  • Protein details for OSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A4U3

    Protein attributes for OSTN Gene

    133 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OSTN Gene

Proteomics data for OSTN Gene at MOPED

Post-translational modifications for OSTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OSTN Gene

Domains & Families for OSTN Gene

Protein Domains for OSTN Gene


Suggested Antigen Peptide Sequences for OSTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OSTN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OSTN Gene

Function for OSTN Gene

Molecular function for OSTN Gene

UniProtKB/Swiss-Prot Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

Gene Ontology (GO) - Molecular Function for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with OSTN: view
genes like me logo Genes that share phenotypes with OSTN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OSTN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSTN Gene

Localization for OSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTN Gene


Subcellular locations from

Jensen Localization Image for OSTN Gene COMPARTMENTS Subcellular localization image for OSTN gene
Compartment Confidence
extracellular 4
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for OSTN Gene

Pathways & Interactions for OSTN Gene

SuperPathways for OSTN Gene

No Data Available

Interacting Proteins for OSTN Gene

Gene Ontology (GO) - Biological Process for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
GO:0045668 negative regulation of osteoblast differentiation IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Pathways by source and SIGNOR curated interactions for OSTN Gene

Drugs & Compounds for OSTN Gene

No Compound Related Data Available

Transcripts for OSTN Gene

mRNA/cDNA for OSTN Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OSTN Gene

No ASD Table

Relevant External Links for OSTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSTN Gene

mRNA expression in normal human tissues for OSTN Gene

mRNA differential expression in normal tissues according to GTEx for OSTN Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x11.1) and Brain - Frontal Cortex (BA9) (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSTN Gene

SOURCE GeneReport for Unigene cluster for OSTN Gene Hs.526794

mRNA Expression by UniProt/SwissProt for OSTN Gene

Tissue specificity: Expressed in bone.
genes like me logo Genes that share expression patterns with OSTN: view

Protein tissue co-expression partners for OSTN Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for OSTN Gene

Orthologs for OSTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSTN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSTN 35
  • 90.4 (n)
  • 92.42 (a)
  • 92 (a)
(Canis familiaris)
Mammalia OSTN 35
  • 89.39 (n)
  • 90.15 (a)
  • 90 (a)
(Mus musculus)
Mammalia Ostn 35
  • 81.03 (n)
  • 76.92 (a)
Ostn 16
Ostn 36
  • 76 (a)
(Pan troglodytes)
Mammalia OSTN 35
  • 99.5 (n)
  • 99.25 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ostn 35
  • 81.57 (n)
  • 78.03 (a)
(Monodelphis domestica)
Mammalia OSTN 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves OSTN 35
  • 61.65 (n)
  • 58.65 (a)
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ostn 35
  • 64.9 (n)
  • 63.64 (a)
(Danio rerio)
Actinopterygii LOC100333936 35
  • 55.74 (n)
  • 51.26 (a)
ostn 36
  • 46 (a)
Species with no ortholog for OSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTN Gene

Gene Tree for OSTN (if available)
Gene Tree for OSTN (if available)

Paralogs for OSTN Gene

No data available for Paralogs for OSTN Gene

Variants for OSTN Gene

Sequence variations from dbSNP and Humsavar for OSTN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2363980 -- 191,233,406(+) TTGTT(C/T)AAAGT intron-variant
rs2363981 -- 191,244,800(+) GATTT(A/T)TATAT intron-variant
rs2364374 -- 191,255,277(+) CCTCC(G/T)GCTGT intron-variant
rs1349921 -- 191,220,281(-) ATAAG(G/T)TATGG intron-variant
rs7432430 -- 191,220,607(+) CTACC(A/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTN Gene

Variant ID Type Subtype PubMed ID
essv7531 CNV CNV 17122850
dgv1544e1 CNV Complex 17122850
dgv5360n71 CNV Loss 21882294
nsv878101 CNV Loss 21882294
nsv878102 CNV Loss 21882294
nsv878104 CNV Loss 21882294
nsv428428 CNV Gain 18775914
esv2661473 CNV Deletion 23128226

Variation tolerance for OSTN Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSTN Gene

Disorders for OSTN Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSTN Gene - From: DISEASES

Disorder Aliases PubMed IDs
acromesomelic dysplasia
  • acromesomelic dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search OSTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for OSTN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OSTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSTN Gene

Publications for OSTN Gene

  1. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. (PMID: 14523025) Thomas G. … Lanctot C. (J. Biol. Chem. 2003) 2 3 4 67
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3
  3. Osteocrin--beyond just another bone protein? (PMID: 19234809) Moffatt P. … Thomas G.P. (Cell. Mol. Life Sci. 2009) 23
  4. Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide. (PMID: 19244276) Kita S. … Shimomura I. (J. Endocrinol. 2009) 23
  5. [Osteocrin is a new signaling molecule acting on bone]. (PMID: 18950569) Moffatt P. (Med Sci (Paris) 2008) 23

Products for OSTN Gene

Sources for OSTN Gene