Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSTN Gene

Aliases for OSTN Gene

  • Osteocrin 2 3
  • MUSCLIN 3 4

External Ids for OSTN Gene

Summaries for OSTN Gene

GeneCards Summary for OSTN Gene

OSTN (Osteocrin) is a Protein Coding gene. Diseases associated with OSTN include acromesomelic dysplasia. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for OSTN Gene

  • Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTN Gene

Genomics for OSTN Gene

Genomic Location for OSTN Gene

191,199,241 bp from pter
191,265,615 bp from pter
66,375 bases
Plus strand

Genomic View for OSTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTN Gene

Regulatory Elements for OSTN Gene

Proteins for OSTN Gene

  • Protein details for OSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A4U3

    Protein attributes for OSTN Gene

    133 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OSTN Gene

Proteomics data for OSTN Gene at MOPED

Post-translational modifications for OSTN Gene

No Post-translational modifications

Other Protein References for OSTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSTN Gene

Domains for OSTN Gene

Protein Domains for OSTN Gene


Suggested Antigen Peptide Sequences for OSTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OSTN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OSTN Gene

Function for OSTN Gene

Molecular function for OSTN Gene

UniProtKB/Swiss-Prot Function: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).

Gene Ontology (GO) - Molecular Function for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with OSTN: view

Phenotypes for OSTN Gene

genes like me logo Genes that share phenotypes with OSTN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OSTN Gene

Localization for OSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTN Gene


Subcellular locations from

Jensen Localization Image for OSTN Gene COMPARTMENTS Subcellular localization image for OSTN gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OSTN: view

Pathways for OSTN Gene

SuperPathways for OSTN Gene

No Data Available

Interacting Proteins for OSTN Gene

Gene Ontology (GO) - Biological Process for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0003416 endochondral bone growth IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0030154 cell differentiation IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Pathways by source for OSTN Gene

Transcripts for OSTN Gene

mRNA/cDNA for OSTN Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OSTN Gene

No ASD Table

Relevant External Links for OSTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSTN Gene

mRNA expression in normal human tissues for OSTN Gene

mRNA differential expression in normal tissues according to GTEx for OSTN Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (11.1) and Brain - Frontal Cortex (BA9) (6.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OSTN Gene

SOURCE GeneReport for Unigene cluster for OSTN Gene Hs.526794

mRNA Expression by UniProt/SwissProt for OSTN Gene

Tissue specificity: Expressed in bone
genes like me logo Genes that share expressions with OSTN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OSTN Gene

Orthologs for OSTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSTN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSTN 35
  • 99.5 (n)
  • 99.25 (a)
  • 99 (a)
(Bos Taurus)
Mammalia OSTN 35
  • 90.4 (n)
  • 92.42 (a)
  • 92 (a)
(Canis familiaris)
Mammalia OSTN 35
  • 89.39 (n)
  • 90.15 (a)
  • 90 (a)
(Mus musculus)
Mammalia Ostn 35
  • 81.03 (n)
  • 76.92 (a)
Ostn 16
Ostn 36
  • 76 (a)
(Monodelphis domestica)
Mammalia OSTN 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Ostn 35
  • 81.57 (n)
  • 78.03 (a)
(Gallus gallus)
Aves OSTN 35
  • 61.65 (n)
  • 58.65 (a)
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ostn 35
  • 64.9 (n)
  • 63.64 (a)
(Danio rerio)
Actinopterygii LOC100333936 35
  • 55.74 (n)
  • 51.26 (a)
ostn 36
  • 46 (a)
Species with no ortholog for OSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTN Gene

Gene Tree for OSTN (if available)
Gene Tree for OSTN (if available)

Paralogs for OSTN Gene

No data available for Paralogs for OSTN Gene

Variants for OSTN Gene

Sequence variations from dbSNP and Humsavar for OSTN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1349921 -- 191,220,281(-) ATAAG(G/T)TATGG intron-variant
rs1454689 -- 191,263,383(-) CATGA(C/T)TGAAA downstream-variant-500B
rs1551426 -- 191,211,580(+) aagca(C/T)ccaat upstream-variant-2KB, intron-variant
rs1551427 -- 191,211,758(+) TTGTC(C/T)CTTCA upstream-variant-2KB, intron-variant
rs1584933 -- 191,255,790(-) aaaac(C/T)gaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTN Gene

Variant ID Type Subtype PubMed ID
essv7531 CNV CNV 17122850
dgv1544e1 CNV Complex 17122850
dgv5360n71 CNV Loss 21882294
nsv878101 CNV Loss 21882294
nsv878102 CNV Loss 21882294
nsv878104 CNV Loss 21882294
nsv428428 CNV Gain 18775914
esv2661473 CNV Deletion 23128226

Relevant External Links for OSTN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTN Gene

Disorders for OSTN Gene

(1) MalaCards Diseases for OSTN Gene

Search for OSTN Gene in MalaCards »

(1) University of Copenhagen DISEASES for OSTN Gene

Relevant External Links for OSTN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OSTN: view

No data available for UniProtKB/Swiss-Prot for OSTN Gene

Publications for OSTN Gene

  1. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. (PMID: 14523025) Thomas G. … Lanctot C. (J. Biol. Chem. 2003) 2 3 4
  2. Musclin, a novel skeletal muscle-derived secretory factor. (PMID: 15044443) Nishizawa H. … Shimomura I. (J. Biol. Chem. 2004) 3 4
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. (PMID: 17950246) Yasui A. … Shimomura I. (Biochem. Biophys. Res. Commun. 2007) 3

Products for OSTN Gene

Sources for OSTN Gene

Back to Top