OSTN Gene
protein-coding GIFtS: 43
GCID: GC03P190917
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osteocrin
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Aliases
for OSTN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Osteocrin1 | | MUSCLIN2 | | Musclin3 |
Export aliases for OSTN gene to outside databasesPrevious GC identifers: GC03U900494 GC03P192251 GC03P192413 GC03P188329 |
Summaries
for OSTN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OSTN_HUMAN, P61366Function: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factorlinked to glucose metabolism in skeletal muscle (By similarity)
|
Genomic Views
for OSTN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OSTN gene promoter:
AhR MEF-2 ATF-2 FOXO3 Evi-1 FOXO3b MEF-2A FOXO3a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OSTN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSTN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q28 HGNC cytogenetic band: 3q29OSTN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P190917: view genomic region
(about GC identifiers)
Start:
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190,917,030 bp from pter |
End:
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190,983,404 bp from pter |
Size:
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66,375 bases |
Orientation:
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plus strand |
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Proteins
for OSTN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OSTN_HUMAN, P61366 (See
protein sequence)Recommended Name: Osteocrin precursor Size: 133 amino acids; 14722 Da
Subcellular location: Secreted
Secondary accessions: A1A4U3Explore the universe of human proteins at neXtProt for OSTN: NX_P61366
OSTN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_937827.1
ENSEMBL proteins: ENSP00000416576 ENSP00000342356
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
OSTN for ontologies About GeneDecksing
OSTN Antibody Products:
Assay Products for OSTN: |
Protein
Domains /
Families
for OSTN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OSTN for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P61366ProtoNet protein and cluster: P61366 |
Function
for OSTN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OSTN_HUMAN, P61366Function: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factorlinked to glucose metabolism in skeletal muscle (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): OSTN (NM_006475) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSTN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005179 | hormone activity |
IEA | -- |
OSTN for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for OSTN:
|
Pathways & Interactions
for OSTN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSTN
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001503 | ossification |
IEA | -- | | GO:0003416 | endochondral bone growth |
IEA | -- | | GO:0007166 | cell surface receptor signaling pathway |
IEA | -- | | GO:0007275 | multicellular organismal development |
-- | -- | | GO:0030154 | cell differentiation |
IEA | -- |
OSTN for ontologies About GeneDecksing
|
Drugs & Compounds
for OSTN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OSTN
Search CenterWatch for drugs/clinical trials and news about OSTN
|
Transcripts
for OSTN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OSTN gene: NM_198184.1 Unigene Cluster for OSTN: Osteocrin Hs.526794 Unigene Representative Sequence: AY3986812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445281 ENST00000339051(uc011bsn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): OSTN (NM_006475) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSTN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTN |
Additional cDNA sequence: AY398681.1 AY573933.1 BC128106.1 BC128107.1 1 DOTS entry: DT.101975383 3 AceView cDNA sequences: AY398681 NM_198184 AY573933
GeneLoc Exon Structure
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Expression
for OSTN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OSTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCGGATTG
About this image
See OSTN Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.526794
UniProtKB/Swiss-Prot: OSTN_HUMAN, P61366Tissue specificity: Expressed in bone
SABiosciences Custom PCR Arrays for OSTN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSTN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSTN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSTN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSTN |
Orthologs
for OSTN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OSTN gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for OSTN (if available)
TreeFam Gene Tree for OSTN (if available) |
Paralogs
for OSTN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OSTN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OSTN (190917030 - 190983404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OSTN
1 CNV: 3469 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSTN |
|
Disorders
/ Diseases
for OSTN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSTN for disorders About GeneDecksing
OMIM gene information: 610280
OMIM disorders: --
1  disease for OSTN: About MalaCardsacromesomelic dysplasia
1 disease from the University of Copenhagen DISEASES database for OSTN:Acromesomelic dysplasia Human Genome Epidemiology (HuGE) Navigator: OSTN (2 documents)
Export disorders for OSTN gene to outside databases
|
Publications
for OSTN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OSTN gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with OSTN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. (PubMed id 14523025)1, 2, 3 Thomas G.... Lanctot C. (2003)
- Musclin, a novel skeletal muscle-derived secretory factor. (PubMed id 15044443)1, 2 Nishizawa H.... Shimomura I. (2004)
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
- Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. (PubMed id 17951249)1 Moffatt P....Lanctot C. (2007)
- Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. (PubMed id 17950246)1 Yasui A....Shimomura I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of osteocrin expression in human bone. (PubMed id 15923362)9 Bord S....Compston J.E. (2005)
- Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide. (PubMed id 19244276)9 Kita S....Shimomura I. (2009)
- Musclin gene expression is strongly related to fast-glycolytic phenotype. (PubMed id 17189616)9 Banzet S....Bigard A.X. (2007)
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External Searches for OSTN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OSTN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OSTN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSTN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OSTN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OSTN gene:
Search GeneIP for patents involving OSTN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OSTN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OSTN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSTN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSTN | | | OriGene Protein Over-expression Lysate for OSTN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OSTN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSTN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OSTN | | OriGene Custom Protein Services for OSTN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSTN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSTN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSTN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSTN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSTN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSTN |
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| | | | Search Tocris compounds for OSTN |
| |  |  |  |  | | | | | | Recombinant Protein for OSTN |
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 | | | OSTN Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OSTN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTN |
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