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OSTF1 Gene

protein-coding   GIFtS: 58
GCID: GC09P077703

Osteoclast Stimulating Factor 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Osteoclast Stimulating Factor 11 2
OSF2 5
SH3P22 5
bA235O14.12
Osteoclast-Stimulating Factor 12

External Ids:    HGNC: 85101   Entrez Gene: 265782   Ensembl: ENSG000001349967   OMIM: 6101805   UniProtKB: Q928823   

Export aliases for OSTF1 gene to outside databases

Previous GC identifers: GC09P068747 GC09P069560 GC09P071273 GC09P073160 GC09P074933 GC09P076893 GC09P047530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSTF1 Gene:
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces
osteoclast formation and bone resorption (Reddy et al., 1998 (PubMed 10092216)).(supplied by OMIM, Mar 2008)

GeneCards Summary for OSTF1 Gene:
OSTF1 (osteoclast stimulating factor 1) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot: OSTF1_HUMAN, Q92882
Function: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of
factor(s) enhancing osteoclast formation and activity

Gene Wiki entry for OSTF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSTF1 gene promoter:
         LHX3b/Lhx3b   USF1   Pbx1a   NCX/Ncx   USF2   USF-1:USF-2   Gfi-1   POU2F1   USF-1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSTF1 promoter sequence
   Search Chromatin IP Primers for OSTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13-q21.2   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q13-q21.2

OSTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSTF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P077703:  view genomic region     (about GC identifiers)

Start:
77,703,398 bp from pter      End:
77,762,181 bp from pter
Size:
58,784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OSTF1_HUMAN, Q92882 (See protein sequence)
Recommended Name: Osteoclast-stimulating factor 1  
Size: 214 amino acids; 23787 Da
Subunit: Interacts with SRC and SMN1. Interacts with FASLG
4 PDB 3D structures from and Proteopedia for OSTF1:
1X2K (3D)        1ZLM (3D)        3EHQ (3D)        3EHR (3D)    
Secondary accessions: Q5W126 Q96IJ4

Explore the universe of human proteins at neXtProt for OSTF1: NX_Q92882

Explore proteomics data for OSTF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82, Lys162
  • Modification sites at PhosphoSitePlus

  • See OSTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036515.4  
    ENSEMBL proteins: 
     ENSP00000340836  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q92882

    ProtoNet protein and cluster: Q92882

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: OSTF1_HUMAN, Q92882
    Domain: The SH3 domain mediates interaction with SMN1
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with OSTF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSTF1_HUMAN, Q92882
    Function: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of
    factor(s) enhancing osteoclast formation and activity

         Genatlas biochemistry entry for OSTF1:
    osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through
    the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related
    proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17500595
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with OSTF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OSTF1:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSTF1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSTF1_HUMAN, Q92882: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS10092216
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with OSTF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSTF1
    Interactions:

        GeneGlobe Interaction Network for OSTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OSTF1 (Q928822, 3 ENSP000003408364) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-14054 MINT-14052 MINT-14053 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-14054 MINT-14052 MINT-14053 I2D: score=2 STRING: ENSP00000370119
    GAPDHP044062, 3, ENSP000002292394MINT-8256393 I2D: score=2 STRING: ENSP00000229239
    MED28Q9H2042, 3, ENSP000002373804MINT-7041728 I2D: score=1 STRING: ENSP00000237380
    MAPK6Q166592, 3MINT-8261582 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification TAS10092216
    GO:0007165signal transduction TAS10092216

    Find genes that share ontologies with OSTF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OSTF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSTF1 gene: 
    NM_012383.4  

    Unigene Cluster for OSTF1:

    Osteoclast stimulating factor 1
    Hs.494192  [show with all ESTs]
    Unigene Representative Sequence: NM_012383
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000346234(uc004ajv.4 uc004ajx.4)
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      QuantiTect SYBR Green Assays in human, mouse, rat OSTF1
      QuantiFast Probe-based Assays in human, mouse, rat OSTF1

    Additional mRNA sequence: 

    AK222596.1 AK291511.1 BC007459.1 U63717.1 

    6 DOTS entries:

    DT.413651  DT.40199021  DT.121150202  DT.121150248  DT.100708428  DT.121150230 

    Selected AceView cDNA sequences (see all 90):

    BF436135 BG757706 BM680954 BM726350 BG255151 CR594571 BE858896 CR601709 
    BQ129388 Z44697 T10745 BF435285 BX476325 AW296380 NM_012383 BQ072477 
    BX395127 AI471111 AA810827 BI548875 T34430 AA528165 BM926189 BQ716481 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                    -                                                                     
    SP2:                                                                                          
    SP3:                    -     -                                                               


    ECgene alternative splicing isoforms for OSTF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTACCAATG
    OSTF1 Expression
    About this image


    OSTF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    OSTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494192

    UniProtKB/Swiss-Prot: OSTF1_HUMAN, Q92882
    Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OSTF1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ostf11 , 5 osteoclast stimulating factor 11, 5 88.16(n)1
    96.26(a)1
      19 (13.17 cM)5
    204091  NM_017375.31  NP_059071.11 
     185793285 
    chicken
    (Gallus gallus)
    Aves OSTF11 osteoclast stimulating factor 1 81.76(n)
    90.05(a)
      427258  NM_001031426.1  NP_001026597.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSTF16
    osteoclast stimulating factor 1
    91(a)
    1 ↔ 1
    2(46842472-46868453)
    African clawed frog
    (Xenopus laevis)
    Amphibia sh3d3-prov2 osteoclast stimulating factor 1 78.1(n)    BC043796.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379731 osteoclast-stimulating factor 1-like 73.21(n)
    81.31(a)
      100537973  XM_003198582.2  XP_003198630.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y106G6H.143
    CELE_Y106G6H.141
    Src homology domain 3 \; Ank repeat3
    CELE_Y106G6H.141
    48(a)3
    53.47(n)1
    50(a)1
      I(10480361-10481443)3
    1729261  NM_060337.31  NP_492738.11 


    ENSEMBL Gene Tree for OSTF1 (if available)
    TreeFam Gene Tree for OSTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSTF1 gene
    ANKRD272  
    4 SIMAP similar genes for OSTF1 using alignment to 1 protein entry:     OSTF1_HUMAN:
    SH3GL2    ARHGEF7    SH3GL1    ITSN1

    Find genes that share paralogs with OSTF1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OSTF1
    PGOHUM00000239937


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSTF1 (see all 1248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70260231,2
    C,A,H--47574763(+) cacacA/CcCCCT 1 -- int10--------
    rs755760601,2
    F--77705187(+) CTATAT/CTGCAA 1 -- int11Minor allele frequency- C:0.01EA 120
    rs775755991,2
    C--77705303(+) ATCCTG/ATTACT 1 -- int13Minor allele frequency- A:0.06NA EA 242
    rs1452540801,2
    --77705380(+) CAGGTA/GTTTAG 1 -- int10--------
    rs108694971,2
    C,F,A,H--77705570(+) CTTTGT/CGTGGG 1 -- int125Minor allele frequency- C:0.43NS EA NA WA CSA 2478
    rs108694981,2
    C,F,A,H--77705609(+) GATGGC/ACAGGA 1 -- int117Minor allele frequency- A:0.15NS EA NA WA CSA 1162
    rs1491563251,2
    C--77705718(+) ACCCCA/GTCTCA 1 -- int10--------
    rs735463301,2
    C--77705841(+) CAACAG/ATCTTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1448020941,2
    --77705900(+) AGATGC/TGCAGA 1 -- int10--------
    rs108694991,2
    C,F,A,H--77705927(+) TCTAAA/GGTCAA 1 -- int114Minor allele frequency- G:0.42NS EA NA WA CSA 790

    HapMap Linkage Disequilibrium report for OSTF1 (77703398 - 77762181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OSTF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893468CNV Gain21882294
    nsv893467CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for OSTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610180    OMIM disorders: --


    Find genes that share disorders with OSTF1           About GenesLikeMe

    Genetic Association Database (GAD): OSTF1
    Human Genome Epidemiology (HuGE) Navigator: OSTF1 (3 documents)

    Export disorders for OSTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSTF1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with OSTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PubMed id 10092216)1, 2, 3 Reddy S.V.... Roodman G.D. (J. Cell. Physiol. 1998)
    2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation. (PubMed id 11551898)1, 2 Kurihara N.... Reddy S.V. (J. Biol. Chem. 2001)
    9. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. (PubMed id 16946461)1, 9 Chen L....Meehan E.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006)
    10. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26578 HGNC: 8510 AceView: OSTF1 Ensembl:ENSG00000134996 euGenes: HUgn26578
    ECgene: OSTF1 H-InvDB: OSTF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSTF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSTF1 gene:
    Search GeneIP for patents involving OSTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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