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Aliases for OSTF1 Gene

Aliases for OSTF1 Gene

  • Osteoclast Stimulating Factor 1 2 3
  • SH3P2 3 6
  • OSF 3 6
  • Osteoclast-Stimulating Factor 1 3
  • BA235O14.1 3

External Ids for OSTF1 Gene

Previous GeneCards Identifiers for OSTF1 Gene

  • GC09P068747
  • GC09P069560
  • GC09P071273
  • GC09P073160
  • GC09P074933
  • GC09P076893
  • GC09P077703
  • GC09P047530

Summaries for OSTF1 Gene

Entrez Gene Summary for OSTF1 Gene

  • Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSTF1 Gene

OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot for OSTF1 Gene

  • Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Wiki entry for OSTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTF1 Gene

Genomics for OSTF1 Gene

Regulatory Elements for OSTF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSTF1 Gene

75,088,482 bp from pter
75,148,137 bp from pter
59,656 bases
Plus strand

Genomic View for OSTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTF1 Gene

Proteins for OSTF1 Gene

  • Protein details for OSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Osteoclast-stimulating factor 1
    Protein Accession:
    Secondary Accessions:
    • Q5W126
    • Q96IJ4

    Protein attributes for OSTF1 Gene

    214 amino acids
    Molecular mass:
    23787 Da
    Quaternary structure:
    • Interacts with SRC and SMN1. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for OSTF1 Gene

neXtProt entry for OSTF1 Gene

Proteomics data for OSTF1 Gene at MOPED

Post-translational modifications for OSTF1 Gene

  • Ubiquitination at Lys82 and Lys162
  • Modification sites at PhosphoSitePlus

Other Protein References for OSTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSTF1 Gene

Domains for OSTF1 Gene

Gene Families for OSTF1 Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for OSTF1 Gene

Suggested Antigen Peptide Sequences for OSTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92882
  • The SH3 domain mediates interaction with SMN1
  • Contains 1 SH3 domain.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with OSTF1: view

Function for OSTF1 Gene

Molecular function for OSTF1 Gene

GENATLAS Biochemistry: osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
UniProtKB/Swiss-Prot Function: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Ontology (GO) - Molecular Function for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with OSTF1: view

Phenotypes for OSTF1 Gene

genes like me logo Genes that share phenotypes with OSTF1: view

Animal Model Products

CRISPR Products

miRNA for OSTF1 Gene

miRTarBase miRNAs that target OSTF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSTF1 Gene

Localization for OSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTF1 Gene


Subcellular locations from

Jensen Localization Image for OSTF1 Gene COMPARTMENTS Subcellular localization image for OSTF1 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10092216
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSTF1: view

Pathways for OSTF1 Gene

SuperPathways for OSTF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification TAS 10092216
GO:0007165 signal transduction TAS 10092216
genes like me logo Genes that share ontologies with OSTF1: view

No data available for Pathways by source for OSTF1 Gene

Transcripts for OSTF1 Gene

mRNA/cDNA for OSTF1 Gene

Unigene Clusters for OSTF1 Gene

Osteoclast stimulating factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP3: - -

Relevant External Links for OSTF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSTF1 Gene

mRNA expression in normal human tissues for OSTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSTF1 Gene

This gene is overexpressed in Whole Blood (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSTF1 Gene

SOURCE GeneReport for Unigene cluster for OSTF1 Gene Hs.494192

mRNA Expression by UniProt/SwissProt for OSTF1 Gene

Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level).
genes like me logo Genes that share expressions with OSTF1: view

In Situ Assay Products

Orthologs for OSTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSTF1 35
  • 99.69 (n)
  • 100 (a)
OSTF1 36
  • 100 (a)
(Bos Taurus)
Mammalia OSTF1 35
  • 93.61 (n)
  • 97.2 (a)
OSTF1 36
  • 97 (a)
(Canis familiaris)
Mammalia OSTF1 35
  • 92.54 (n)
  • 98.03 (a)
OSTF1 36
  • 97 (a)
(Mus musculus)
Mammalia Ostf1 35
  • 88.16 (n)
  • 96.26 (a)
Ostf1 16
Ostf1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia OSTF1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia OSTF1 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Ostf1 35
  • 88.01 (n)
  • 95.79 (a)
(Gallus gallus)
Aves OSTF1 35
  • 81.76 (n)
  • 90.05 (a)
OSTF1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia OSTF1 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia sh3d3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ostf1 35
  • 76.64 (n)
  • 87.38 (a)
Str.7364 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.445 35
(Danio rerio)
Actinopterygii LOC100537973 35
  • 73.21 (n)
  • 81.31 (a)
ostf1 36
  • 72 (a)
ostf1 36
  • 69 (a)
ostf1 36
  • 77 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y106G6H.14 35
  • 53.47 (n)
  • 50 (a)
Y106G6H.14 36
  • 48 (a)
Y106G6H.14 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1316 36
  • 53 (a)
Species with no ortholog for OSTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSTF1 Gene

Gene Tree for OSTF1 (if available)
Gene Tree for OSTF1 (if available)

Paralogs for OSTF1 Gene

Paralogs for OSTF1 Gene

Selected SIMAP similar genes for OSTF1 Gene using alignment to 1 proteins: Pseudogenes for OSTF1 Gene

genes like me logo Genes that share paralogs with OSTF1: view

Variants for OSTF1 Gene

Sequence variations from dbSNP and Humsavar for OSTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs140764 -- 75,135,460(+) CTTGT(-/ATT/TAT)ATTTC intron-variant
rs764437 -- 75,135,330(+) TATGT(A/G)TGATC intron-variant
rs1009282 -- 75,138,051(-) GCACC(C/T)GCTCA intron-variant
rs1009376 -- 75,091,615(+) TGGGA(C/T)TGGGG intron-variant
rs1010198 -- 75,093,812(-) AGTAT(C/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTF1 Gene

Variant ID Type Subtype PubMed ID
nsv893467 CNV Gain 21882294
nsv893468 CNV Gain 21882294

Relevant External Links for OSTF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTF1 Gene

Disorders for OSTF1 Gene

Relevant External Links for OSTF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OSTF1: view

No data available for UniProtKB/Swiss-Prot for OSTF1 Gene

Publications for OSTF1 Gene

  1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PMID: 10092216) Reddy S.V. … Roodman G.D. (J. Cell. Physiol. 1998) 2 3 4
  2. Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation. (PMID: 11551898) Kurihara N. … Reddy S.V. (J. Biol. Chem. 2001) 3 4
  3. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. (PMID: 16946461) Chen L. … Meehan E.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 23
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OSTF1 Gene

Sources for OSTF1 Gene

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