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Aliases for OSTF1 Gene

Aliases for OSTF1 Gene

  • Osteoclast Stimulating Factor 1 2 3
  • BA235O14.1 3
  • SH3P2 3
  • OSF 3

External Ids for OSTF1 Gene

Previous GeneCards Identifiers for OSTF1 Gene

  • GC09P068747
  • GC09P069560
  • GC09P071273
  • GC09P073160
  • GC09P074933
  • GC09P076893
  • GC09P077703
  • GC09P047530

Summaries for OSTF1 Gene

Entrez Gene Summary for OSTF1 Gene

  • Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSTF1 Gene

OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot for OSTF1 Gene

  • Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Wiki entry for OSTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTF1 Gene

Genomics for OSTF1 Gene

Regulatory Elements for OSTF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSTF1 Gene

Chromosome:
9
Start:
75,088,482 bp from pter
End:
75,148,137 bp from pter
Size:
59,656 bases
Orientation:
Plus strand

Genomic View for OSTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTF1 Gene

Proteins for OSTF1 Gene

  • Protein details for OSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92882-OSTF1_HUMAN
    Recommended name:
    Osteoclast-stimulating factor 1
    Protein Accession:
    Q92882
    Secondary Accessions:
    • Q5W126
    • Q96IJ4

    Protein attributes for OSTF1 Gene

    Size:
    214 amino acids
    Molecular mass:
    23787 Da
    Quaternary structure:
    • Interacts with SRC and SMN1. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for OSTF1 Gene

neXtProt entry for OSTF1 Gene

Proteomics data for OSTF1 Gene at MOPED

Post-translational modifications for OSTF1 Gene

  • Ubiquitination at Lys 82 and Lys 162
  • Modification sites at PhosphoSitePlus

Other Protein References for OSTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for OSTF1
  • Santa Cruz Biotechnology (SCBT) Antibodies for OSTF1

No data available for DME Specific Peptides for OSTF1 Gene

Domains & Families for OSTF1 Gene

Gene Families for OSTF1 Gene

Protein Domains for OSTF1 Gene

Suggested Antigen Peptide Sequences for OSTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92882

UniProtKB/Swiss-Prot:

OSTF1_HUMAN :
  • The SH3 domain mediates interaction with SMN1
  • Contains 3 ANK repeats.
Domain:
  • The SH3 domain mediates interaction with SMN1
  • Contains 1 SH3 domain.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with OSTF1: view

Function for OSTF1 Gene

Molecular function for OSTF1 Gene

GENATLAS Biochemistry:
osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
UniProtKB/Swiss-Prot Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Ontology (GO) - Molecular Function for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with OSTF1: view
genes like me logo Genes that share phenotypes with OSTF1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OSTF1 Gene

Localization for OSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSTF1 Gene COMPARTMENTS Subcellular localization image for OSTF1 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10092216
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSTF1: view

Pathways & Interactions for OSTF1 Gene

SuperPathways for OSTF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification TAS 10092216
GO:0007165 signal transduction TAS 10092216
genes like me logo Genes that share ontologies with OSTF1: view

No data available for Pathways by source and SIGNOR curated interactions for OSTF1 Gene

Drugs & Compounds for OSTF1 Gene

No Compound Related Data Available

Transcripts for OSTF1 Gene

mRNA/cDNA for OSTF1 Gene

Unigene Clusters for OSTF1 Gene

Osteoclast stimulating factor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -

Relevant External Links for OSTF1 Gene

GeneLoc Exon Structure for
OSTF1
ECgene alternative splicing isoforms for
OSTF1

Expression for OSTF1 Gene

mRNA expression in normal human tissues for OSTF1 Gene

mRNA differential expression in normal tissues according to GTEx for OSTF1 Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for OSTF1 Gene

This gene is overexpressed in Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSTF1 Gene



SOURCE GeneReport for Unigene cluster for OSTF1 Gene Hs.494192

mRNA Expression by UniProt/SwissProt for OSTF1 Gene

Q92882-OSTF1_HUMAN
Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level).
genes like me logo Genes that share expression patterns with OSTF1: view

Protein tissue co-expression partners for OSTF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OSTF1 Gene

Orthologs for OSTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSTF1 35
  • 93.61 (n)
  • 97.2 (a)
OSTF1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSTF1 35
  • 92.54 (n)
  • 98.03 (a)
OSTF1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ostf1 35
  • 88.16 (n)
  • 96.26 (a)
Ostf1 16
Ostf1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSTF1 35
  • 99.69 (n)
  • 100 (a)
OSTF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ostf1 35
  • 88.01 (n)
  • 95.79 (a)
oppossum
(Monodelphis domestica)
Mammalia OSTF1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSTF1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSTF1 35
  • 81.76 (n)
  • 90.05 (a)
OSTF1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSTF1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ostf1 35
  • 76.64 (n)
  • 87.38 (a)
Str.7364 35
African clawed frog
(Xenopus laevis)
Amphibia sh3d3-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537973 35
  • 73.21 (n)
  • 81.31 (a)
ostf1 36
  • 72 (a)
OneToMany
ostf1 36
  • 69 (a)
OneToMany
ostf1 36
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.445 35
worm
(Caenorhabditis elegans)
Secernentea Y106G6H.14 37
  • 48 (a)
CELE_Y106G6H.14 35
  • 53.47 (n)
  • 50 (a)
Y106G6H.14 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1316 36
  • 53 (a)
OneToOne
Species with no ortholog for OSTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSTF1 Gene

ENSEMBL:
Gene Tree for OSTF1 (if available)
TreeFam:
Gene Tree for OSTF1 (if available)

Paralogs for OSTF1 Gene

Paralogs for OSTF1 Gene

(4) SIMAP similar genes for OSTF1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OSTF1 Gene

genes like me logo Genes that share paralogs with OSTF1: view

Variants for OSTF1 Gene

Sequence variations from dbSNP and Humsavar for OSTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs140764 -- 75,135,460(+) CTTGT(-/ATT/TAT)ATTTC intron-variant
rs764437 -- 75,135,330(+) TATGT(A/G)TGATC intron-variant
rs1009282 -- 75,138,051(-) GCACC(C/T)GCTCA intron-variant
rs1009376 -- 75,091,615(+) TGGGA(C/T)TGGGG intron-variant
rs1010198 -- 75,093,812(-) AGTAT(C/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTF1 Gene

Variant ID Type Subtype PubMed ID
nsv893467 CNV Gain 21882294
nsv893468 CNV Gain 21882294

Variation tolerance for OSTF1 Gene

Residual Variation Intolerance Score: 52.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSTF1 Gene

HapMap Linkage Disequilibrium report
OSTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTF1 Gene

Disorders for OSTF1 Gene

Relevant External Links for OSTF1

Genetic Association Database (GAD)
OSTF1
Human Genome Epidemiology (HuGE) Navigator
OSTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSTF1
genes like me logo Genes that share disorders with OSTF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTF1 Gene

Publications for OSTF1 Gene

  1. A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. (PMID: 16941570) GarcA-a A. … Zitzmann N. (Proteomics 2006) 23 67
  2. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. (PMID: 16946461) Chen L. … Meehan E.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 23 67
  3. Proteomic analysis of cholesteatoma. (PMID: 15370560) Kim J.L. … Jung H.H. (Acta Otolaryngol. 2004) 23 67
  4. Molecular cloning and expression of the osteoclast-stimulating-factor-like gene from the rice field eel. (PMID: 15054860) Xia L. … Zhou R. (J. Exp. Zool. B Mol. Dev. Evol. 2004) 23 67
  5. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PMID: 10092216) Reddy S.V. … Roodman G.D. (J. Cell. Physiol. 1998) 2 67

Products for OSTF1 Gene

Sources for OSTF1 Gene

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