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Aliases for OSTF1 Gene

Aliases for OSTF1 Gene

  • Osteoclast Stimulating Factor 1 2 3 5
  • BA235O14.1 3
  • SH3P2 3
  • OSF 3

External Ids for OSTF1 Gene

Previous GeneCards Identifiers for OSTF1 Gene

  • GC09P068747
  • GC09P069560
  • GC09P071273
  • GC09P073160
  • GC09P074933
  • GC09P076893
  • GC09P077703
  • GC09P047530

Summaries for OSTF1 Gene

Entrez Gene Summary for OSTF1 Gene

  • Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSTF1 Gene

OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot for OSTF1 Gene

  • Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Wiki entry for OSTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTF1 Gene

Genomics for OSTF1 Gene

Regulatory Elements for OSTF1 Gene

Enhancers for OSTF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSTF1 on UCSC Golden Path with GeneCards custom track

Promoters for OSTF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSTF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSTF1 Gene

75,088,482 bp from pter
75,148,137 bp from pter
59,656 bases
Plus strand

Genomic View for OSTF1 Gene

Genes around OSTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTF1 Gene

Proteins for OSTF1 Gene

  • Protein details for OSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Osteoclast-stimulating factor 1
    Protein Accession:
    Secondary Accessions:
    • Q5W126
    • Q96IJ4

    Protein attributes for OSTF1 Gene

    214 amino acids
    Molecular mass:
    23787 Da
    Quaternary structure:
    • Interacts with SRC and SMN1. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for OSTF1 Gene

neXtProt entry for OSTF1 Gene

Proteomics data for OSTF1 Gene at MOPED

Post-translational modifications for OSTF1 Gene

  • Ubiquitination at Lys 82 and Lys 162
  • Modification sites at PhosphoSitePlus

Other Protein References for OSTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSTF1 Gene

Domains & Families for OSTF1 Gene

Gene Families for OSTF1 Gene

Protein Domains for OSTF1 Gene

Suggested Antigen Peptide Sequences for OSTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The SH3 domain mediates interaction with SMN1.
  • Contains 3 ANK repeats.
  • The SH3 domain mediates interaction with SMN1.
  • Contains 1 SH3 domain.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with OSTF1: view

Function for OSTF1 Gene

Molecular function for OSTF1 Gene

GENATLAS Biochemistry:
osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
UniProtKB/Swiss-Prot Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
genes like me logo Genes that share phenotypes with OSTF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSTF1 Gene

Localization for OSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTF1 Gene


Subcellular locations from

Jensen Localization Image for OSTF1 Gene COMPARTMENTS Subcellular localization image for OSTF1 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for OSTF1 Gene

Pathways & Interactions for OSTF1 Gene

SuperPathways for OSTF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSTF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OSTF1 Gene

Drugs & Compounds for OSTF1 Gene

No Compound Related Data Available

Transcripts for OSTF1 Gene

mRNA/cDNA for OSTF1 Gene

Unigene Clusters for OSTF1 Gene

Osteoclast stimulating factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP3: - -

Relevant External Links for OSTF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSTF1 Gene

mRNA expression in normal human tissues for OSTF1 Gene

mRNA differential expression in normal tissues according to GTEx for OSTF1 Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for OSTF1 Gene

This gene is overexpressed in Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSTF1 Gene

SOURCE GeneReport for Unigene cluster for OSTF1 Gene Hs.494192

mRNA Expression by UniProt/SwissProt for OSTF1 Gene

Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level).
genes like me logo Genes that share expression patterns with OSTF1: view

Protein tissue co-expression partners for OSTF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OSTF1 Gene

Orthologs for OSTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSTF1 35
  • 93.61 (n)
  • 97.2 (a)
OSTF1 36
  • 97 (a)
(Canis familiaris)
Mammalia OSTF1 35
  • 92.54 (n)
  • 98.03 (a)
OSTF1 36
  • 97 (a)
(Mus musculus)
Mammalia Ostf1 35
  • 88.16 (n)
  • 96.26 (a)
Ostf1 16
Ostf1 36
  • 96 (a)
(Pan troglodytes)
Mammalia OSTF1 35
  • 99.69 (n)
  • 100 (a)
OSTF1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ostf1 35
  • 88.01 (n)
  • 95.79 (a)
(Monodelphis domestica)
Mammalia OSTF1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia OSTF1 36
  • 86 (a)
(Gallus gallus)
Aves OSTF1 35
  • 81.76 (n)
  • 90.05 (a)
OSTF1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia OSTF1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ostf1 35
  • 76.64 (n)
  • 87.38 (a)
Str.7364 35
African clawed frog
(Xenopus laevis)
Amphibia sh3d3-prov 35
(Danio rerio)
Actinopterygii LOC100537973 35
  • 73.21 (n)
  • 81.31 (a)
ostf1 36
  • 72 (a)
ostf1 36
  • 69 (a)
ostf1 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.445 35
(Caenorhabditis elegans)
Secernentea Y106G6H.14 37
  • 48 (a)
CELE_Y106G6H.14 35
  • 53.47 (n)
  • 50 (a)
Y106G6H.14 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1316 36
  • 53 (a)
Species with no ortholog for OSTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSTF1 Gene

Gene Tree for OSTF1 (if available)
Gene Tree for OSTF1 (if available)

Paralogs for OSTF1 Gene

Paralogs for OSTF1 Gene

(4) SIMAP similar genes for OSTF1 Gene using alignment to 1 proteins: Pseudogenes for OSTF1 Gene

genes like me logo Genes that share paralogs with OSTF1: view

Variants for OSTF1 Gene

Sequence variations from dbSNP and Humsavar for OSTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17850197 - 75,137,604(+) AGTTG(C/T)TTCTG reference, missense
rs2295862 - 75,130,588(+) TACCA(A/G)TTGGT reference, missense
rs764437 -- 75,135,330(+) TATGT(A/G)TGATC intron-variant
rs1009282 -- 75,138,051(-) GCACC(C/T)GCTCA intron-variant
rs1009376 -- 75,091,615(+) TGGGA(C/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTF1 Gene

Variant ID Type Subtype PubMed ID
nsv893467 CNV Gain 21882294
nsv893468 CNV Gain 21882294

Variation tolerance for OSTF1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSTF1 Gene

Disorders for OSTF1 Gene

Relevant External Links for OSTF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTF1 Gene

Publications for OSTF1 Gene

  1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PMID: 10092216) Reddy S.V. … Roodman G.D. (J. Cell. Physiol. 1998) 2 3 4 67
  2. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. (PMID: 16946461) Chen L. … Meehan E.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S. … Weiss S.T. (BMC Med Genomics 2014) 3

Products for OSTF1 Gene

Sources for OSTF1 Gene