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Aliases for OSTF1 Gene

Aliases for OSTF1 Gene

  • Osteoclast Stimulating Factor 1 2 3 5
  • Osteoclast-Stimulating Factor 1 3
  • BA235O14.1 3
  • SH3P2 3
  • OSF 3

External Ids for OSTF1 Gene

Previous GeneCards Identifiers for OSTF1 Gene

  • GC09P068747
  • GC09P069560
  • GC09P071273
  • GC09P073160
  • GC09P074933
  • GC09P076893
  • GC09P077703
  • GC09P047530

Summaries for OSTF1 Gene

Entrez Gene Summary for OSTF1 Gene

  • Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSTF1 Gene

OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ACBD6.

UniProtKB/Swiss-Prot for OSTF1 Gene

  • Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Wiki entry for OSTF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTF1 Gene

Genomics for OSTF1 Gene

Regulatory Elements for OSTF1 Gene

Enhancers for OSTF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G074951 1.1 ENCODE 17.2 -135.6 -135640 3.3 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 NMRK1 OSTF1 C9orf41-AS1 CARNMT1 TRPM6 RNU6-445P C9orf40 LOC100133316
GH09G075141 0.6 ENCODE dbSUPER 20.9 +53.9 53858 0.9 CTCF NMRK1 OSTF1 LOC105376090
GH09G075167 1.1 Ensembl ENCODE 10.9 +81.1 81128 4.3 ATF1 JUN ETV1 RAD21 FOSL1 ZNF766 ZNF316 POLR3A GATA2 NFE2 NMRK1 OSTF1 RNU6-1228P ENSG00000200041 LOC105376090
GH09G075110 1 Ensembl ENCODE dbSUPER 11.7 +22.9 22893 1.3 PKNOX1 FOS ZBTB40 NMRK1 OSTF1 CARNMT1 LOC105376090
GH09G075000 1 ENCODE 11.2 -87.0 -87030 2.1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZHX2 MXD4 CARNMT1 OSTF1 NMRK1 C9orf40 GC09P074993 ENSG00000229587
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSTF1 on UCSC Golden Path with GeneCards custom track

Promoters for OSTF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000236052 -182 3401 PKNOX1 FOXA2 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF207 ZNF263 SP3

Genomic Location for OSTF1 Gene

Chromosome:
9
Start:
75,088,482 bp from pter
End:
75,148,137 bp from pter
Size:
59,656 bases
Orientation:
Plus strand

Genomic View for OSTF1 Gene

Genes around OSTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTF1 Gene

Proteins for OSTF1 Gene

  • Protein details for OSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92882-OSTF1_HUMAN
    Recommended name:
    Osteoclast-stimulating factor 1
    Protein Accession:
    Q92882
    Secondary Accessions:
    • Q5W126
    • Q96IJ4

    Protein attributes for OSTF1 Gene

    Size:
    214 amino acids
    Molecular mass:
    23787 Da
    Quaternary structure:
    • Interacts with SRC and SMN1. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for OSTF1 Gene

neXtProt entry for OSTF1 Gene

Post-translational modifications for OSTF1 Gene

  • Ubiquitination at Lys82 and Lys162
  • Modification sites at PhosphoSitePlus

Other Protein References for OSTF1 Gene

No data available for DME Specific Peptides for OSTF1 Gene

Domains & Families for OSTF1 Gene

Gene Families for OSTF1 Gene

Suggested Antigen Peptide Sequences for OSTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92882

UniProtKB/Swiss-Prot:

OSTF1_HUMAN :
  • The SH3 domain mediates interaction with SMN1.
Domain:
  • The SH3 domain mediates interaction with SMN1.
genes like me logo Genes that share domains with OSTF1: view

Function for OSTF1 Gene

Molecular function for OSTF1 Gene

GENATLAS Biochemistry:
osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
UniProtKB/Swiss-Prot Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Ontology (GO) - Molecular Function for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with OSTF1: view
genes like me logo Genes that share phenotypes with OSTF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSTF1 Gene

Localization for OSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSTF1 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS 10092216
GO:0005737 cytoplasm IEA --
GO:0034774 secretory granule lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSTF1: view

Pathways & Interactions for OSTF1 Gene

genes like me logo Genes that share pathways with OSTF1: view

Pathways by source for OSTF1 Gene

3 Reactome pathways for OSTF1 Gene

Gene Ontology (GO) - Biological Process for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification TAS 10092216
GO:0007165 signal transduction TAS 10092216
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with OSTF1: view

No data available for SIGNOR curated interactions for OSTF1 Gene

Drugs & Compounds for OSTF1 Gene

No Compound Related Data Available

Transcripts for OSTF1 Gene

mRNA/cDNA for OSTF1 Gene

Unigene Clusters for OSTF1 Gene

Osteoclast stimulating factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -

Relevant External Links for OSTF1 Gene

GeneLoc Exon Structure for
OSTF1
ECgene alternative splicing isoforms for
OSTF1

Expression for OSTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSTF1 Gene

mRNA differential expression in normal tissues according to GTEx for OSTF1 Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for OSTF1 Gene

This gene is overexpressed in Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSTF1 Gene



Protein tissue co-expression partners for OSTF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSTF1 Gene:

OSTF1

SOURCE GeneReport for Unigene cluster for OSTF1 Gene:

Hs.494192

mRNA Expression by UniProt/SwissProt for OSTF1 Gene:

Q92882-OSTF1_HUMAN
Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level).

Evidence on tissue expression from TISSUES for OSTF1 Gene

  • Blood(4.4)
  • Bone marrow(4.3)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with OSTF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSTF1 Gene

Orthologs for OSTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSTF1 34 35
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia OSTF1 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSTF1 34 35
  • 93.61 (n)
dog
(Canis familiaris)
Mammalia OSTF1 34 35
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Ostf1 34 16 35
  • 88.16 (n)
rat
(Rattus norvegicus)
Mammalia Ostf1 34
  • 88.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OSTF1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSTF1 34 35
  • 81.76 (n)
lizard
(Anolis carolinensis)
Reptilia OSTF1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ostf1 34
  • 76.64 (n)
Str.7364 34
African clawed frog
(Xenopus laevis)
Amphibia sh3d3-prov 34
zebrafish
(Danio rerio)
Actinopterygii LOC100537888 34
  • 73.21 (n)
ostf1 35 35 35
  • 72 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.445 34
worm
(Caenorhabditis elegans)
Secernentea CELE_Y106G6H.14 34
  • 53.47 (n)
Y106G6H.14 36 35
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1316 35
  • 53 (a)
OneToOne
Species where no ortholog for OSTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSTF1 Gene

ENSEMBL:
Gene Tree for OSTF1 (if available)
TreeFam:
Gene Tree for OSTF1 (if available)

Paralogs for OSTF1 Gene

Paralogs for OSTF1 Gene

(4) SIMAP similar genes for OSTF1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OSTF1 Gene

genes like me logo Genes that share paralogs with OSTF1: view

Variants for OSTF1 Gene

Sequence variations from dbSNP and Humsavar for OSTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000011585 -- 75,089,091(+) CTTTA(A/G)CCACT intron-variant, upstream-variant-2KB
rs1000013149 -- 75,088,532(+) GCTCT(G/T)CCTGC upstream-variant-2KB, utr-variant-5-prime
rs1000022544 -- 75,115,873(+) CTCAG(A/G)CAGGC intron-variant
rs1000093404 -- 75,122,075(+) TTCTT(C/T)TTTCT intron-variant
rs1000145780 -- 75,106,562(+) ATTGC(C/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTF1 Gene

Variant ID Type Subtype PubMed ID
esv3573267 CNV loss 25503493

Variation tolerance for OSTF1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTF1 Gene

Disorders for OSTF1 Gene

Relevant External Links for OSTF1

Genetic Association Database (GAD)
OSTF1
Human Genome Epidemiology (HuGE) Navigator
OSTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSTF1

No disorders were found for OSTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTF1 Gene

Publications for OSTF1 Gene

  1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PMID: 10092216) Reddy S.V. … Roodman G.D. (J. Cell. Physiol. 1998) 2 3 4 64
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4 64
  5. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. (PMID: 16946461) Chen L. … Meehan E.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 22 64

Products for OSTF1 Gene

Sources for OSTF1 Gene

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