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Aliases for OSTC Gene

Aliases for OSTC Gene

  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
  • Hydrophobic Protein HSF-28 3 4
  • Oligosaccharyltransferase Complex Subunit OSTC 3
  • Oligosaccharyltransferase Complex Subunit 2
  • DC2 Protein 2
  • DC2 3

External Ids for OSTC Gene

Previous GeneCards Identifiers for OSTC Gene

  • GC04P109793
  • GC04P109572
  • GC04P105303

Summaries for OSTC Gene

GeneCards Summary for OSTC Gene

OSTC (Oligosaccharyltransferase Complex Subunit (Non-Catalytic)) is a Protein Coding gene. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTC Gene

Genomics for OSTC Gene

Regulatory Elements for OSTC Gene

Genomic Location for OSTC Gene

Start:
108,650,584 bp from pter
End:
108,667,822 bp from pter
Size:
17,239 bases
Orientation:
Plus strand

Genomic View for OSTC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSTC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTC Gene

Proteins for OSTC Gene

  • Protein details for OSTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRP0-OSTC_HUMAN
    Recommended name:
    Oligosaccharyltransferase complex subunit OSTC
    Protein Accession:
    Q9NRP0
    Secondary Accessions:
    • A8MYS2
    • B2R5H1
    • D6RH22
    • Q9P075
    • Q9P1R4

    Protein attributes for OSTC Gene

    Size:
    149 amino acids
    Molecular mass:
    16829 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).
    SequenceCaution:
    • Sequence=AAF28985.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF65186.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CN430159; Type=Frameshift; Positions=134; Evidence={ECO:0000305};

    Alternative splice isoforms for OSTC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSTC Gene

Proteomics data for OSTC Gene at MOPED

Post-translational modifications for OSTC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTC Gene

No data available for DME Specific Peptides for OSTC Gene

Domains for OSTC Gene

Protein Domains for OSTC Gene

Suggested Antigen Peptide Sequences for OSTC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRP0

UniProtKB/Swiss-Prot:

OSTC_HUMAN :
  • Q9NRP0
Family:
  • Belongs to the OSTC family.
genes like me logo Genes that share domains with OSTC: view

No data available for Gene Families for OSTC Gene

Function for OSTC Gene

Gene Ontology (GO) - Molecular Function for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC 15835887
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OSTC: view

Phenotypes for OSTC Gene

GenomeRNAi human phenotypes for OSTC:
genes like me logo Genes that share phenotypes with OSTC: view

Animal Model Products

CRISPR Products

miRNA for OSTC Gene

miRTarBase miRNAs that target OSTC

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSTC Gene

Localization for OSTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTC Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSTC Gene COMPARTMENTS Subcellular localization image for OSTC gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
endosome 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008250 oligosaccharyltransferase complex IDA 15835887
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OSTC: view

Pathways for OSTC Gene

SuperPathways for OSTC Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine IC 15835887
genes like me logo Genes that share ontologies with OSTC: view

No data available for Pathways by source for OSTC Gene

Transcripts for OSTC Gene

Unigene Clusters for OSTC Gene

Oligosaccharyltransferase complex subunit (non-catalytic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSTC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: -

Relevant External Links for OSTC Gene

GeneLoc Exon Structure for
OSTC
ECgene alternative splicing isoforms for
OSTC

Expression for OSTC Gene

mRNA expression in normal human tissues for OSTC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSTC Gene

SOURCE GeneReport for Unigene cluster for OSTC Gene Hs.445803

genes like me logo Genes that share expressions with OSTC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OSTC Gene

Orthologs for OSTC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSTC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSTC 35
  • 99.78 (n)
  • 100 (a)
OSTC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSTC 35
  • 93.51 (n)
  • 97.99 (a)
OSTC 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSTC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ostc 35
  • 89.71 (n)
  • 99.33 (a)
Ostc 16
Ostc 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSTC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSTC 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ostc 35
  • 89.71 (n)
  • 99.33 (a)
chicken
(Gallus gallus)
Aves OSTC 35
  • 81.66 (n)
  • 94.63 (a)
OSTC 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSTC 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29128 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ostc 35
  • 81.66 (n)
  • 97.32 (a)
Str.227 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8547 35
zebrafish
(Danio rerio)
Actinopterygii ostc 35
  • 76.73 (n)
  • 93.96 (a)
ostc 36
  • 91 (a)
OneToOne
zgc56559 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008475 35
  • 67.57 (n)
  • 70.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9662 35
  • 60.5 (n)
  • 63.01 (a)
CG9662 36
  • 60 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19340 35
  • 52.38 (n)
  • 47.14 (a)
rice
(Oryza sativa)
Liliopsida Os02g0315400 35
  • 49.65 (n)
  • 46.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3186 36
  • 67 (a)
OneToOne
Species with no ortholog for OSTC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTC Gene

ENSEMBL:
Gene Tree for OSTC (if available)
TreeFam:
Gene Tree for OSTC (if available)

Paralogs for OSTC Gene

Selected SIMAP similar genes for OSTC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSTC: view

No data available for Paralogs for OSTC Gene

Variants for OSTC Gene

Sequence variations from dbSNP and Humsavar for OSTC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11185 -- 108,667,646(-) TCTGG(A/G)TTTTA utr-variant-3-prime
rs1369962 -- 108,662,629(-) TCAAG(C/T)CATAG intron-variant
rs2060585 -- 108,666,487(+) gatgg(A/C)ttaac intron-variant
rs2060586 -- 108,666,745(+) tcacg(C/T)gtgta intron-variant
rs2060587 -- 108,666,826(+) catgg(C/T)gaaaa intron-variant

Relevant External Links for OSTC Gene

HapMap Linkage Disequilibrium report
OSTC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OSTC Gene

Disorders for OSTC Gene

Relevant External Links for OSTC

Genetic Association Database (GAD)
OSTC
Human Genome Epidemiology (HuGE) Navigator
OSTC
genes like me logo Genes that share disorders with OSTC: view

No data available for UniProtKB/Swiss-Prot for OSTC Gene

Publications for OSTC Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 48
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 4
  3. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 2 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OSTC Gene

Sources for OSTC Gene

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