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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OSTC Gene

protein-coding GIFtS: 45
GCID: GC04P109572

oligosaccharyltransferase complex subunit

Explore 4 diseases affiliated with
OSTC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oligosaccharyltransferase Complex Subunit¹ ²
Hydrophobic Protein HSF-28² ³
DC2¹
Oligosaccharyltransferase Complex Subunit OSTC²

External Ids:	HGNC: 24448¹	Entrez Gene: 58505²	Ensembl: ENSG00000198856⁷	UniProtKB: Q9NRP0³

Export aliases for OSTC gene to outside databases

Previous GC identifers: GC04P109793 GC04P105303

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OSTC gene promoter:
SRF AML1a SRF (504 AA) XBP-1 Meis-1b Egr-2 MZF-1 Zic1 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OSTC promoter sequence

Search SABiosciences Chromatin IP Primers for OSTC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSTC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25

OSTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSTC gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P109572: view genomic region (about GC identifiers)

Start:	109,571,740 bp from pter	End:	109,588,978 bp from pter
Size:	17,239 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSTC_HUMAN, Q9NRP0 (See protein sequence)

Recommended Name: Oligosaccharyltransferase complex subunit OSTC

Size: 149 amino acids; 16829 Da

Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain

at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the

Sec61 complex or with both the Sec61 and TRAP complexes (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=AAF28985.1; Type=Erroneous initiation; Sequence=AAF65186.1; Type=Erroneous initiation;

Secondary accessions: A8MYS2 B2R5H1 Q9P075 Q9P1R4

Explore the universe of human proteins at neXtProt for OSTC: NX_Q9NRP0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NRP0

OSTC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001254746.1 NP_001254747.1 NP_067050.1

ENSEMBL proteins:

ENSP00000354676 ENSP00000426167

Human Recombinant Protein Products for OSTC:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: OSTC OriGene Custom Protein Services for OSTC
	GenScript Custom Purified and Recombinant Proteins Services for OSTC
	Novus Biologicals OSTC Protein Novus Biologicals OSTC Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OSTC

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008250	oligosaccharyltransferase complex	IDA	15835887
GO:0016021	integral to membrane	IEA	--

OSTC for ontologies About GeneDecksing

OSTC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for OSTC
	Novus Biologicals OSTC Antibody
	Abcam antibodies for OSTC
	Uscn Antibodies for OSTC
	Search ThermoFisher Antibodies for OSTC

Assay Products for OSTC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OSTC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OSTC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OSTC for domains About GeneDecksing

1 InterPro domain/family:

IPR021149 OligosaccharylTrfase_OST3/OST6

Graphical View of Domain Structure for InterPro Entry Q9NRP0

ProtoNet protein and cluster: Q9NRP0

UniProtKB/Swiss-Prot: OSTC_HUMAN, Q9NRP0

Similarity: Belongs to the OSTC family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004579	contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IC	15835887

OSTC for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for OSTC:

Increased S DNA content

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OSTC

miRNA Products:		OriGene 3'-UTR Clone: OSTC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSTC
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate OSTC (see all 10):
		hsa-miR-320a hsa-miR-485-3p hsa-miR-29a hsa-miR-29c hsa-miR-320d hsa-miR-3692 hsa-miR-320b hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: OSTC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSTC (see all 3) OriGene siRNA: OSTC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSTC
		Sirion Biotech Custom design and validation of potent shRNA sequences against OSTC

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for OSTC
			Sirion Biotech Customized adenovirus for overexpression of OSTC Sirion Biotech Customized adenovirus for potent knockdown of OSTC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSTC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSTC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OSTC (NM_021227)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSTC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OSTC
		Search LifeMap BioReagents cell lines for OSTC
		Sirion Biotech Customized stable knockdown cell line services for OSTC Sirion Biotech Customized inducible knockdown cell line services for OSTC Sirion Biotech Customized stable overexpressing cell line services for OSTC Sirion Biotech Customized inducible overexpressing cell line services for OSTC

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OSTC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OSTC

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/20 Interacting proteins for OSTC (Q9NRP0³ ENSP00000354676⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSC22D1	Q15714³, ENSP00000397435⁴	I2D: score=1 STRING: ENSP00000397435
DAD1	ENSP00000250498⁴	STRING: ENSP00000250498
MAGT1	ENSP00000354649⁴	STRING: ENSP00000354649
RPN1	ENSP00000296255⁴	STRING: ENSP00000296255
RPN2	ENSP00000237530⁴	STRING: ENSP00000237530

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0018279	protein N-linked glycosylation via asparagine	IC	15835887

OSTC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OSTC
Search CenterWatch for drugs/clinical trials and news about OSTC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OSTC gene (3 alternative transcripts):

NM_001267817.1 NM_001267818.1 NM_021227.3

Unigene Cluster for OSTC:

Oligosaccharyltransferase complex subunit

Hs.445803 [show with all ESTs]

Unigene Representative Sequence: BF698884

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361564(uc003hzb.1) ENST00000510556 ENST00000505745 ENST00000512478

miRNA Products:		OriGene 3'-UTR Clone: OSTC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSTC
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate OSTC (see all 10):
		hsa-miR-320a hsa-miR-485-3p hsa-miR-29a hsa-miR-29c hsa-miR-320d hsa-miR-3692 hsa-miR-320b hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: OSTC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSTC (see all 3) OriGene siRNA: OSTC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSTC
		Sirion Biotech Custom design and validation of potent shRNA sequences against OSTC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSTC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSTC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OSTC (NM_021227)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSTC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSTC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSTC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSTC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSTC

Additional cDNA sequence:

AF068297.1 AF161425.1 AF201937.1 AF343342.1 AK312185.1 BC016321.1 BC054857.1

20 DOTS entries:

DT.449886 DT.100693052 DT.100693017 DT.100874983 DT.100693010 DT.99994326 DT.100753275 DT.92467749

DT.92467759 DT.92467761 DT.92467775 DT.95269008 DT.121248087 DT.92020858 DT.92467758 DT.95269007

DT.95269022 DT.121405124 DT.86855522 DT.95192977

24/757 AceView cDNA sequences (see all 757):

CA312148 CR597339 AA776979 CD676840 CA309939 BQ777650 BE042617 BX282080

CB136790 BQ772330 BQ574432 BX414917 AA300003 BF724501 AA099179 BQ013984

AW273470 BG546572 AA976910 BM561622 AA369186 BE567837 BU607621 CA313777

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OSTC About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b
SP1:
SP2:									-
SP3:					-

ECgene alternative splicing isoforms for OSTC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OSTC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGAAAC

About this image

OSTC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OSTC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSTC

SOURCE GeneReport for Unigene cluster: Hs.445803

SABiosciences Custom PCR Arrays for OSTC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSTC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSTC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSTC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSTC

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OSTC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSTC gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ostc^{1 , 5}	oligosaccharyltransferase complex subunit^{1, 5}	89.71(n)¹ 99.33(a)¹		3 (60.53 cM)⁵ 66357¹ NM_025509.3¹ NP_079785.1¹ 130695921⁵
chicken (Gallus gallus)	Aves	OSTC¹	oligosaccharyltransferase complex subunit	81.66(n) 94.63(a)		422525 NM_001006442.1 NP_001006442.1
lizard (Anolis carolinensis)	Reptilia	OSTC⁶	--	95(a)	1 ↔ 1	5(145077048-145081685)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29128²	Xenopus laevis transcribed sequence with strong similarity more	81.16(n)		48035333
zebrafish (Danio rerio)	Actinopterygii	zgc56559²	similar to DC2 protein	78.91(n)		393239 BC049047.1
fruit fly (Drosophila melanogaster)	Insecta	CG9662¹	CG9662	60.5(n) 63.01(a)		33554 NM_134928.5 NP_608772.3
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G19340¹	Oligosaccharyltransferase complex/magnesium transporter more	52.62(n) 47.14(a)		816451 NM_179656.2 NP_849987.1
rice (Oryza sativa)	Liliopsida	Os02g0315400¹	hypothetical protein	49.41(n) 46.1(a)		4329143 NM_001053198.1 NP_001046663.1

ENSEMBL Gene Tree for OSTC (if available)
TreeFam Gene Tree for OSTC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OSTC gene

5 SIMAP similar genes for OSTC using alignment to 2 protein entries: OSTC_HUMAN (see all proteins):

OSTCL RBMS2 NLN MST132 ACTR10

OSTC for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for OSTC (see all 9)
PGOHUM00000262983 PGOHUM00000234776 PGOHUM00000243945 PGOHUM00000244001 PGOHUM00000244692

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145096867^1,2		--	109569812(+)	`TGTGTC/TCTGAC`	3	--	us2k¹		0	--	--	--	--
rs2851384^1,2	C,F,A,H	--	109569824(-)	`TAAAAT/CTGCCA`	3	--	us2k¹		13		NS EA NA WA CSA	782
rs2575650^1,2	C,F,H	--	109570062(+)	`AGGAGT/CCACTT`	3	--	us2k¹		17		NA NS EA WA CSA	928
rs181322207^1,2		--	109570167(+)	`GCCAAG/TCAGTG`	3	--	us2k¹		0	--	--	--	--
rs184320490^1,2		--	109570221(+)	`AAAAAC/TCTTTA`	3	--	us2k¹		0	--	--	--	--
rs2851383^1,2	C,F,O,A,H	--	109570461(-)	`TAACGC/GAGCCA`	3	--	us2k¹		20		NA NS EA WA CSA	1001
rs2851382^1,2	C,F,O,A,H	--	109570589(-)	`AATTGT/CTTGAA`	3	--	us2k¹		25		NA NS EA WA CSA	1531
rs150989631^1,2		--	109570683(+)	`AGCAAA/CTAAAA`	3	--	us2k¹		0	--	--	--	--
rs140845685^1,2		--	109570775(+)	`GGAAGC/TTAACA`	3	--	us2k¹		0	--	--	--	--
rs114254979^1,2	F	--	109570812(+)	`AAAAAG/CAAAAG`	3	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for OSTC (109571740 - 109588978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OSTC: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSTC

DNA2.0 Custom Variant and Variant Library Synthesis for OSTC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OSTC for disorders About GeneDecksing

4 diseases for OSTC: About MalaCards

alcohol dependence alcoholism intrahepatic cholangiocarcinoma cholangiocarcinoma

Human Genome Epidemiology (HuGE) Navigator: OSTC (1 document)

Export disorders for OSTC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OSTC gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with OSTC)

Utopia: connect your pdf to the dynamic
world of online information

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)^{1, 3} Shibatani T.... Skach W.R. (2005)
Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)¹ Usenovic M....Krainc D. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)¹ Kalsi G....Riley B.P. (2010)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58505	HGNC: 24448	AceView: DC2	Ensembl:ENSG00000198856	euGenes: HUgn58505
ECgene: OSTC	H-InvDB: OSTC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OSTC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OSTC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for OSTC gene:
Search GeneIP for patents involving OSTC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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OSTC Gene

oligosaccharyltransferase complex subunit

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OSTC Gene

oligosaccharyltransferase complex subunit

Aliasesfor OSTC gene

Summariesfor OSTC gene

Genomic Viewsfor OSTC gene

Proteinsfor OSTC gene

Protein Domains /Familiesfor OSTC gene

Functionfor OSTC gene

Pathways & Interactionsfor OSTC gene

Drugs & Compoundsfor OSTC gene

Transcriptsfor OSTC gene

Expression for OSTC gene

Orthologsfor OSTC gene

Paralogsfor OSTC gene

Genomic Variantsfor OSTC gene

Disorders / Diseasesfor OSTC gene

Publicationsfor OSTC gene

External Searches for OSTC gene

Genome Databases showing OSTC gene

Other Databases showing OSTC gene

Specialized Databases showing OSTC gene

Intellectual Propertyfor OSTC gene

Productsfor OSTC gene

View Random Gene

Aliases
for OSTC gene

Summaries
for OSTC gene

Genomic Views
for OSTC gene

Proteins
for OSTC gene

Protein Domains /
Families
for OSTC gene

Function
for OSTC gene

Pathways & Interactions
for OSTC gene

Drugs & Compounds
for OSTC gene

Transcripts
for OSTC gene

Expression
for OSTC gene

Orthologs
for OSTC gene

Paralogs
for OSTC gene

Genomic Variants
for OSTC gene

Disorders / Diseases
for OSTC gene

Publications
for OSTC gene

Intellectual Property
for OSTC gene

Products
for OSTC gene