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OSTC Gene

protein-coding   GIFtS: 49
GCID: GC04P109572

Oligosaccharyltransferase Complex Subunit (Non-Catalytic)

(Previous name: oligosaccharyltransferase complex subunit)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oligosaccharyltransferase Complex Subunit (Non-Catalytic)1 2
Hydrophobic Protein HSF-282 3
DC2 Protein1
Oligosaccharyltransferase Complex Subunit1
Oligosaccharyltransferase Complex Subunit OSTC2

External Ids:    HGNC: 244481   Entrez Gene: 585052   Ensembl: ENSG000001988567   UniProtKB: Q9NRP03   

Export aliases for OSTC gene to outside databases

Previous GC identifers: GC04P109793 GC04P105303


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OSTC Gene:
OSTC (oligosaccharyltransferase complex subunit (non-catalytic)) is a protein-coding gene. Diseases associated with OSTC include alcohol dependence, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSTC gene promoter:
         SRF   AML1a   SRF (504 AA)   XBP-1   Meis-1b   Egr-2   MZF-1   Zic1   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OSTC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

OSTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSTC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P109572:  view genomic region     (about GC identifiers)

Start:
109,571,740 bp from pter      End:
109,588,978 bp from pter
Size:
17,239 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OSTC_HUMAN, Q9NRP0 (See protein sequence)
Recommended Name: Oligosaccharyltransferase complex subunit OSTC  
Size: 149 amino acids; 16829 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which
contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes
with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity)
Sequence caution: Sequence=AAF28985.1; Type=Erroneous initiation; Sequence=AAF65186.1; Type=Erroneous initiation;
Sequence=CN430159; Type=Frameshift; Positions=134;
Secondary accessions: A8MYS2 B2R5H1 D6RH22 Q9P075 Q9P1R4
Alternative splicing: 2 isoforms:  Q9NRP0-1   Q9NRP0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSTC: NX_Q9NRP0

Explore proteomics data for OSTC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSTC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254746.1  NP_001254747.1  NP_067050.1  

    ENSEMBL proteins: 
     ENSP00000354676   ENSP00000426167  

    OSTC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OSTC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OSTC
    GenScript Custom Purified and Recombinant Proteins Services for OSTC
    Novus Biologicals OSTC Protein
    Novus Biologicals OSTC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSTC

    OSTC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OSTC
    OriGene Custom Antibody Services for OSTC
    Novus Biologicals OSTC Antibody
    Abcam antibodies for OSTC
    Cloud-Clone Corp. Antibodies for OSTC
    ThermoFisher Antibodies for OSTC
    LSBio Antibodies in human, mouse, rat for OSTC

    OSTC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSTC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSTC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSTC
    Cloud-Clone Corp. CLIAs for OSTC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021149 OligosaccharylTrfase_OST3/OST6

    Graphical View of Domain Structure for InterPro Entry Q9NRP0

    ProtoNet protein and cluster: Q9NRP0

    UniProtKB/Swiss-Prot: OSTC_HUMAN, Q9NRP0
    Similarity: Belongs to the OSTC family


    OSTC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC15835887
         
    OSTC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for OSTC:
     Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSTC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSTC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSTC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSTC

    miRNA
    Products:
        
    miRTarBase miRNAs that target OSTC:
    hsa-mir-324-5p (MIRT043072)

    Block miRNA regulation of human, mouse, rat OSTC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSTC (see all 10):
    hsa-miR-320a hsa-miR-485-3p hsa-miR-29a hsa-miR-29c hsa-miR-320d hsa-miR-3692 hsa-miR-320b hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSTC
    Predesigned siRNA for gene silencing in human, mouse, rat OSTC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSTC

    Clone
    Products:
         
    OriGene clones in human, mouse for OSTC (see all 6)
    OriGene ORF clones in mouse, rat for OSTC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSTC (NM_021227)
    Sino Biological Human cDNA Clone for OSTC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSTC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSTC
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSTC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSTC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSTC_HUMAN, Q9NRP0: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    endosome1
    extracellular1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008250oligosaccharyltransferase complex IDA15835887
    GO:0016021integral component of membrane IEA--

    OSTC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSTC
    Interactions:

        Search GeneGlobe Interaction Network for OSTC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for OSTC (Q9NRP03 ENSP000003546764) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    DAD1ENSP000002504984STRING: ENSP00000250498
    MAGT1ENSP000003546494STRING: ENSP00000354649
    RPN1ENSP000002962554STRING: ENSP00000296255
    RPN2ENSP000002375304STRING: ENSP00000237530
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine IC15835887

    OSTC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSTC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OSTC gene (3 alternative transcripts): 
    NM_001267817.1  NM_001267818.1  NM_021227.3  

    Unigene Cluster for OSTC:

    Oligosaccharyltransferase complex subunit (non-catalytic)
    Hs.445803  [show with all ESTs]
    Unigene Representative Sequence: BF698884
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361564(uc003hzb.1) ENST00000510556 ENST00000505745 ENST00000512478

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OSTC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSTC (see all 10):
    hsa-miR-320a hsa-miR-485-3p hsa-miR-29a hsa-miR-29c hsa-miR-320d hsa-miR-3692 hsa-miR-320b hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSTC
    Predesigned siRNA for gene silencing in human, mouse, rat OSTC
    Clone
    Products:
         
    OriGene clones in human, mouse for OSTC (see all 6)
    OriGene ORF clones in mouse, rat for OSTC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSTC (NM_021227)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSTC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSTC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OSTC
    OriGene qSTAR qPCR primer pairs in human, mouse for OSTC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSTC
      QuantiTect SYBR Green Assays in human, mouse, rat OSTC
      QuantiFast Probe-based Assays in human, mouse, rat OSTC

    Additional mRNA sequence: 

    AF068297.1 AF161425.1 AF201937.1 AF343342.1 AK312185.1 BC016321.1 BC054857.1 

    22 DOTS entries:

    DT.449886  DT.100693052  DT.100693017  DT.100874983  DT.100693010  DT.99994326  DT.100753275  DT.92467749 
    DT.92467759  DT.92467761  DT.92467775  DT.95269008  DT.121248087  DT.92020858  DT.92467758  DT.95269007 
    DT.95269022  DT.100767874  DT.121405124  DT.86855522  DT.92461139  DT.95192977 

    Selected AceView cDNA sequences (see all 757):

    AI126339 AA470450 AW769410 BU951038 CA942851 CB160429 BC016321 AI023025 
    BU682562 CA414093 AA976910 BG546572 AW273470 BQ013984 AA099179 BF724501 
    BX414917 AA300003 BQ574432 CB136790 BQ772330 BQ777650 BE042617 BX282080 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OSTC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                          
    SP2:                          -               
    SP3:              -                           


    ECgene alternative splicing isoforms for OSTC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSTC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATGAAAC
    OSTC Expression
    About this image


    OSTC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Rib
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    OSTC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSTC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445803
        Custom PCR Arrays for OSTC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OSTC
    OriGene qSTAR qPCR primer pairs in human, mouse for OSTC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSTC
    QuantiTect SYBR Green Assays in human, mouse, rat OSTC
    QuantiFast Probe-based Assays in human, mouse, rat OSTC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSTC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSTC gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ostc1 , 5 oligosaccharyltransferase complex subunit1, 5 89.71(n)1
    99.33(a)1
      3 (60.53 cM)5
    663571  NM_025509.31  NP_079785.11 
     1306959215 
    chicken
    (Gallus gallus)
    Aves OSTC1 oligosaccharyltransferase complex subunit 81.66(n)
    94.63(a)
      422525  NM_001006442.1  NP_001006442.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSTC6
    oligosaccharyltransferase complex subunit (non-cat...
    93(a)
    1 ↔ 1
    5(145076010-145082067)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.291282 Xenopus laevis transcribed sequence with strong similarity more 81.16(n)    48035333 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565592 similar to DC2 protein 78.91(n)   393239  BC049047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96621 CG9662 60.5(n)
    63.01(a)
      33554  NM_134928.6  NP_608772.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G193401 AT2G19340 52.38(n)
    47.14(a)
      816451  NM_179656.2  NP_849987.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g03154001 Os02g0315400 49.65(n)
    46.1(a)
      4329143  NM_001053198.1  NP_001046663.1 


    ENSEMBL Gene Tree for OSTC (if available)
    TreeFam Gene Tree for OSTC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSTC gene
    1 SIMAP similar gene for OSTC using alignment to 1 protein entry:     OSTC_HUMAN:
    OSTCL

    OSTC for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for OSTC (see all 9)
    PGOHUM00000262983 PGOHUM00000234776 PGOHUM00000243945 PGOHUM00000244001 PGOHUM00000244692


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSTC (see all 424)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0392314
    A breast cancer sample4--see VAR_0392312 F L mis40--------
    rs1450968671,2
    --109569812(+) TGTGTC/TCTGAC 3 -- us2k10--------
    rs28513841,2
    C,F,A,H--109569824(-) TAAAAT/CTGCCA 3 -- us2k113Minor allele frequency- C:0.11NS EA NA WA CSA 782
    rs25756501,2
    C,F,H--109570062(+) AGGAGT/CCACTT 3 -- us2k117Minor allele frequency- C:0.12NA NS EA WA CSA 928
    rs1813222071,2
    --109570167(+) GCCAAG/TCAGTG 3 -- us2k10--------
    rs1843204901,2
    C--109570221(+) AAAAAC/TCTTTA 3 -- us2k10--------
    rs28513831,2
    C,F,O,A,H--109570461(-) TAACGC/GAGCCA 3 -- us2k120Minor allele frequency- G:0.15NA NS EA WA CSA 1001
    rs28513821,2
    C,F,O,A,H--109570589(-) AATTGT/CTTGAA 3 -- us2k125Minor allele frequency- C:0.13NA NS EA WA CSA 1531
    rs1509896311,2
    --109570683(+) AGCAAA/CTAAAA 3 -- us2k10--------
    rs1408456851,2
    --109570775(+) GGAAGC/TTAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSTC (109571740 - 109588978 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OSTC: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSTC
    DNA2.0 Custom Variant and Variant Library Synthesis for OSTC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for OSTC:    
    About MalaCards
    alcohol dependence    intrahepatic cholangiocarcinoma    cholangiocarcinoma    breast and colorectal cancer
    malaria    colorectal cancer


    OSTC for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSTC
    Human Genome Epidemiology (HuGE) Navigator: OSTC (1 document)

    Export disorders for OSTC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSTC gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with OSTC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    2. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 3 Shibatani T.... Skach W.R. (Biochemistry 2005)
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1, 2 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (Hum. Mol. Genet. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58505 HGNC: 24448 AceView: DC2 Ensembl:ENSG00000198856 euGenes: HUgn58505
    ECgene: OSTC H-InvDB: OSTC

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSTC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSTC gene:
    Search GeneIP for patents involving OSTC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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