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Aliases for OSTC Gene

Aliases for OSTC Gene

  • Oligosaccharyltransferase Complex Non-Catalytic Subunit 2 3 5
  • Hydrophobic Protein HSF-28 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 3
  • Oligosaccharyltransferase Complex Subunit OSTC 3
  • Oligosaccharyltransferase Complex Subunit 2
  • DC2 Protein 2
  • DC2 3

External Ids for OSTC Gene

Previous GeneCards Identifiers for OSTC Gene

  • GC04P109793
  • GC04P109572
  • GC04P105303

Summaries for OSTC Gene

GeneCards Summary for OSTC Gene

OSTC (Oligosaccharyltransferase Complex Non-Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot for OSTC Gene

  • May act as substrate-specific component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (beta-amyloid precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTC Gene

Genomics for OSTC Gene

Regulatory Elements for OSTC Gene

Enhancers for OSTC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G108649 1.1 ENCODE 0.7 +0.3 293 2.5 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 OSTC GC04P108653
GH04G108645 0.4 dbSUPER 0.7 -3.9 -3879 1.4 ZNF316 MAFK RPL34-AS1 RPL34 OSTC PIR53159
GH04G108643 0.4 ENCODE 0.4 -6.2 -6241 1.2 JUND GATA2 OSTC PIR53159
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSTC on UCSC Golden Path with GeneCards custom track

Promoters for OSTC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171735 416 2401 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for OSTC Gene

Chromosome:
4
Start:
108,650,584 bp from pter
End:
108,667,822 bp from pter
Size:
17,239 bases
Orientation:
Plus strand

Genomic View for OSTC Gene

Genes around OSTC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTC Gene

Proteins for OSTC Gene

  • Protein details for OSTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRP0-OSTC_HUMAN
    Recommended name:
    Oligosaccharyltransferase complex subunit OSTC
    Protein Accession:
    Q9NRP0
    Secondary Accessions:
    • A8MYS2
    • B2R5H1
    • D6RH22
    • Q9P075
    • Q9P1R4

    Protein attributes for OSTC Gene

    Size:
    149 amino acids
    Molecular mass:
    16829 Da
    Quaternary structure:
    • May be an accessory component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.
    SequenceCaution:
    • Sequence=AAF28985.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF65186.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CN430159; Type=Frameshift; Positions=134; Evidence={ECO:0000305};

    Alternative splice isoforms for OSTC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSTC Gene

Post-translational modifications for OSTC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTC Gene

No data available for DME Specific Peptides for OSTC Gene

Domains & Families for OSTC Gene

Gene Families for OSTC Gene

Protein Domains for OSTC Gene

Suggested Antigen Peptide Sequences for OSTC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRP0

UniProtKB/Swiss-Prot:

OSTC_HUMAN :
  • Belongs to the OSTC family.
Family:
  • Belongs to the OSTC family.
genes like me logo Genes that share domains with OSTC: view

Function for OSTC Gene

Molecular function for OSTC Gene

UniProtKB/Swiss-Prot Function:
May act as substrate-specific component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (beta-amyloid precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

Gene Ontology (GO) - Molecular Function for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC 15835887
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OSTC: view
genes like me logo Genes that share phenotypes with OSTC: view

Animal Model Products

CRISPR Products

miRNA for OSTC Gene

miRTarBase miRNAs that target OSTC

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSTC Gene

Localization for OSTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTC Gene

Endoplasmic reticulum. Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSTC gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008250 oligosaccharyltransferase complex IDA 15835887
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OSTC: view

Pathways & Interactions for OSTC Gene

No Data Available

UniProtKB/Swiss-Prot Q9NRP0-OSTC_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for OSTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine IC 15835887
genes like me logo Genes that share ontologies with OSTC: view

No data available for Pathways by source and SIGNOR curated interactions for OSTC Gene

Transcripts for OSTC Gene

Unigene Clusters for OSTC Gene

Oligosaccharyltransferase complex subunit (non-catalytic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: -

Relevant External Links for OSTC Gene

GeneLoc Exon Structure for
OSTC
ECgene alternative splicing isoforms for
OSTC

Expression for OSTC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSTC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OSTC Gene

This gene is overexpressed in Nasal epithelium (32.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSTC Gene



Protein tissue co-expression partners for OSTC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSTC Gene:

OSTC

SOURCE GeneReport for Unigene cluster for OSTC Gene:

Hs.445803

Evidence on tissue expression from TISSUES for OSTC Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Blood(4.1)
  • Liver(3.7)
  • Lung(3.4)
  • Pancreas(3.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with OSTC: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSTC Gene

Orthologs for OSTC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSTC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSTC 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia OSTC 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSTC 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSTC 34 35
  • 93.51 (n)
mouse
(Mus musculus)
Mammalia Ostc 34 16 35
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Ostc 34
  • 89.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OSTC 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSTC 34 35
  • 81.66 (n)
lizard
(Anolis carolinensis)
Reptilia OSTC 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ostc 34
  • 81.66 (n)
Str.227 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29128 34
zebrafish
(Danio rerio)
Actinopterygii ostc 34 35
  • 76.73 (n)
zgc56559 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8547 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008475 34
  • 67.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9662 35 34
  • 60.5 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19340 34
  • 52.38 (n)
rice
(Oryza sativa)
Liliopsida Os02g0315400 34
  • 49.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3186 35
  • 67 (a)
OneToOne
Species where no ortholog for OSTC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSTC Gene

ENSEMBL:
Gene Tree for OSTC (if available)
TreeFam:
Gene Tree for OSTC (if available)

Paralogs for OSTC Gene

(1) SIMAP similar genes for OSTC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSTC: view

No data available for Paralogs for OSTC Gene

Variants for OSTC Gene

Sequence variations from dbSNP and Humsavar for OSTC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_039231 A breast cancer sample
rs1000054461 -- 108,666,555(+) AAATA(G/T)AAAAA intron-variant, upstream-variant-2KB
rs1000210648 -- 108,657,882(+) ACTTT(G/T)TCCTG intron-variant
rs1000292980 -- 108,662,594(+) CTTTC(C/T)CTCTT intron-variant
rs1000349841 -- 108,660,074(+) ACCTT(C/T)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSTC Gene

Variant ID Type Subtype PubMed ID
esv3354137 CNV insertion 20981092
esv3601724 CNV gain 21293372
nsv1129420 OTHER inversion 24896259
nsv1131816 CNV deletion 24896259
nsv964080 CNV duplication 23825009
nsv966306 CNV duplication 23825009

Variation tolerance for OSTC Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSTC Gene

Human Gene Mutation Database (HGMD)
OSTC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSTC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTC Gene

Disorders for OSTC Gene

Relevant External Links for OSTC

Genetic Association Database (GAD)
OSTC
Human Genome Epidemiology (HuGE) Navigator
OSTC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSTC

No disorders were found for OSTC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTC Gene

Publications for OSTC Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  2. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 2 3 64
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for OSTC Gene

Sources for OSTC Gene

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