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Aliases for OST4 Gene

Aliases for OST4 Gene

  • Oligosaccharyltransferase Complex Subunit 4, Non-Catalytic 2 3
  • Oligosaccharyltransferase Complex Subunit 4 (Non-Catalytic) 2 5
  • Oligosaccharyltransferase 4 Homolog (S. Cerevisiae) 2

External Ids for OST4 Gene

Previous GeneCards Identifiers for OST4 Gene

  • GC02M027294
  • GC02M027035

Summaries for OST4 Gene

GeneCards Summary for OST4 Gene

OST4 (Oligosaccharyltransferase Complex Subunit 4, Non-Catalytic) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OST4 Gene

  • May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OST4 Gene

Genomics for OST4 Gene

Regulatory Elements for OST4 Gene

Promoters for OST4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OST4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OST4 Gene

Chromosome:
2
Start:
27,070,472 bp from pter
End:
27,071,773 bp from pter
Size:
1,302 bases
Orientation:
Minus strand

Genomic View for OST4 Gene

Genes around OST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OST4 Gene

Proteins for OST4 Gene

  • Protein details for OST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C6T2-OST4_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
    Protein Accession:
    P0C6T2

    Protein attributes for OST4 Gene

    Size:
    37 amino acids
    Molecular mass:
    4193 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1/ribophorin-1, RPN2/ribophorin-2, OST48, DAD1, and either STT3A or STT3B.

    Three dimensional structures from OCA and Proteopedia for OST4 Gene

neXtProt entry for OST4 Gene

Proteomics data for OST4 Gene at MOPED

Post-translational modifications for OST4 Gene

No Post-translational modifications

Other Protein References for OST4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OST4 Gene

Domains & Families for OST4 Gene

Gene Families for OST4 Gene

Protein Domains for OST4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OST4 Gene

Graphical View of Domain Structure for InterPro Entry

P0C6T2

UniProtKB/Swiss-Prot:

OST4_HUMAN :
  • Belongs to the OST4 family.
Family:
  • Belongs to the OST4 family.
genes like me logo Genes that share domains with OST4: view

Function for OST4 Gene

Molecular function for OST4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.

Phenotypes for OST4 Gene

genes like me logo Genes that share phenotypes with OST4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OST4 Gene

Localization for OST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OST4 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=The single transmembrane helix has a kink in the middle of the transmembrane span.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OST4 Gene COMPARTMENTS Subcellular localization image for OST4 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for OST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with OST4: view

Pathways & Interactions for OST4 Gene

SuperPathways for OST4 Gene

No Data Available

Interacting Proteins for OST4 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000454411%0d%0a9606.ENSP00000376472%0d%0a9606.ENSP00000295770%0d%0a9606.ENSP00000223641%0d%0a9606.ENSP00000296255%0d%0a
Selected Interacting proteins: ENSP00000454411 for OST4 Gene via STRING

Gene Ontology (GO) - Biological Process for OST4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OST4 Gene

Drugs & Compounds for OST4 Gene

No Compound Related Data Available

Transcripts for OST4 Gene

mRNA/cDNA for OST4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OST4 Gene

Oligosaccharyltransferase 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OST4 Gene

No ASD Table

Relevant External Links for OST4 Gene

GeneLoc Exon Structure for
OST4
ECgene alternative splicing isoforms for
OST4

Expression for OST4 Gene

mRNA expression in normal human tissues for OST4 Gene

SOURCE GeneReport for Unigene cluster for OST4 Gene Hs.502948

genes like me logo Genes that share expression patterns with OST4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OST4 Gene

Orthologs for OST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OST4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ost4 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ost4 36
  • 95 (a)
OneToOne
Species with no ortholog for OST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OST4 Gene

ENSEMBL:
Gene Tree for OST4 (if available)
TreeFam:
Gene Tree for OST4 (if available)

Paralogs for OST4 Gene

No data available for Paralogs for OST4 Gene

Variants for OST4 Gene

Sequence variations from dbSNP and Humsavar for OST4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1898921 -- 27,073,680(-) TTTCC(C/T)TCCtt upstream-variant-2KB
rs1898922 -- 27,073,282(-) CACTT(C/T)CAAGG upstream-variant-2KB
rs4665943 -- 27,073,017(+) TGAAA(C/T)CCCAG upstream-variant-2KB
rs7608002 -- 27,071,937(+) CCCGG(A/G)GCCGA upstream-variant-2KB
rs13024181 -- 27,073,437(+) ggatc(A/C)cctga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OST4 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv873752 CNV Loss 21882294

Relevant External Links for OST4 Gene

HapMap Linkage Disequilibrium report
OST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OST4 Gene

Disorders for OST4 Gene

Relevant External Links for OST4

Genetic Association Database (GAD)
OST4
Human Genome Epidemiology (HuGE) Navigator
OST4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OST4

No disorders were found for OST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OST4 Gene

Publications for OST4 Gene

  1. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PMID: 23606741) Dumax-Vorzet A. … High S. (J. Cell. Sci. 2013) 2 3 67
  2. An evolving view of the eukaryotic oligosaccharyltransferase. (PMID: 16317064) Kelleher D.J. … Gilmore R. (Glycobiology 2006) 2 3
  3. Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. (PMID: 21609714) Gayen S. … Kang C. (Biochem. Biophys. Res. Commun. 2011) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for OST4 Gene

Sources for OST4 Gene

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