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Aliases for OST4 Gene

Aliases for OST4 Gene

  • Oligosaccharyltransferase 4 Homolog (S. Cerevisiae) 2 3
  • DDOST 6
  • OST48 6
  • CDG1R 6
  • OST 6

External Ids for OST4 Gene

Previous GeneCards Identifiers for OST4 Gene

  • GC02M027294
  • GC02M027035

Summaries for OST4 Gene

GeneCards Summary for OST4 Gene

OST4 (Oligosaccharyltransferase 4 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

UniProtKB/Swiss-Prot for OST4 Gene

  • May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OST4 Gene

Genomics for OST4 Gene

Genomic Location for OST4 Gene

27,070,472 bp from pter
27,071,773 bp from pter
1,302 bases
Minus strand

Genomic View for OST4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OST4 Gene

No data available for Regulatory Elements for OST4 Gene

Proteins for OST4 Gene

  • Protein details for OST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for OST4 Gene

    37 amino acids
    Molecular mass:
    4193 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1/ribophorin-1, RPN2/ribophorin-2, OST48, DAD1, and either STT3A or STT3B.

    Three dimensional structures from OCA and Proteopedia for OST4 Gene

neXtProt entry for OST4 Gene

Proteomics data for OST4 Gene at MOPED

Post-translational modifications for OST4 Gene

No Post-translational modifications

Other Protein References for OST4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OST4 Gene

Domains for OST4 Gene

Gene Families for OST4 Gene

Protein Domains for OST4 Gene


Suggested Antigen Peptide Sequences for OST4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OST4 family.
  • Belongs to the OST4 family.
genes like me logo Genes that share domains with OST4: view

Function for OST4 Gene

Molecular function for OST4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.

miRNA for OST4 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for OST4 Gene

Localization for OST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OST4 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=The single transmembrane helix has a kink in the middle of the transmembrane span.

Gene Ontology (GO) - Cellular Components for OST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OST4: view

No data available for Subcellular locations from COMPARTMENTS for OST4 Gene

Pathways for OST4 Gene

genes like me logo Genes that share pathways with OST4: view

Pathways by source for OST4 Gene

Interacting Proteins for OST4 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000454411 for OST4 Gene via STRING

Gene Ontology (GO) - Biological Process for OST4 Gene


Transcripts for OST4 Gene

mRNA/cDNA for OST4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OST4 Gene

Oligosaccharyltransferase 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OST4 Gene

No ASD Table

Relevant External Links for OST4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OST4 Gene

mRNA expression in normal human tissues for OST4 Gene

SOURCE GeneReport for Unigene cluster for OST4 Gene Hs.502948

genes like me logo Genes that share expressions with OST4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OST4 Gene

Orthologs for OST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OST4 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Ost4 16
Ost4 36
  • 100 (a)
(Danio rerio)
Actinopterygii ost4 36
  • 95 (a)
Species with no ortholog for OST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OST4 Gene

Gene Tree for OST4 (if available)
Gene Tree for OST4 (if available)

Paralogs for OST4 Gene

No data available for Paralogs for OST4 Gene

Variants for OST4 Gene

Sequence variations from dbSNP and Humsavar for OST4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1898921 -- 27,073,680(-) TTTCC(C/T)TCCtt upstream-variant-2KB
rs1898922 -- 27,073,282(-) CACTT(C/T)CAAGG upstream-variant-2KB
rs4665943 -- 27,073,017(+) TGAAA(C/T)CCCAG upstream-variant-2KB
rs5830035 -- 27,072,861(+) CACCC(-/A)AGGGC upstream-variant-2KB
rs55635235 -- 27,072,299(+) GAAAT(A/C)GGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OST4 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv873752 CNV Loss 21882294

Relevant External Links for OST4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OST4 Gene

Disorders for OST4 Gene

(1) OMIM Diseases for OST4 Gene (602202)

Relevant External Links for OST4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for OST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OST4 Gene

Publications for OST4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. (PMID: 21609714) Gayen S. … Kang C. (Biochem. Biophys. Res. Commun. 2011) 3 4
  3. An evolving view of the eukaryotic oligosaccharyltransferase. (PMID: 16317064) Kelleher D.J. … Gilmore R. (Glycobiology 2006) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for OST4 Gene

Sources for OST4 Gene

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