OST4 Gene
protein-coding GIFtS: 31
GCID: GC02M027294
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oligosaccharyltransferase 4 homolog (S. cerevisiae)
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Aliases
for OST4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oligosaccharyltransferase 4 Homolog (S. Cerevisiae)1 2 | | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 42 |
Export aliases for OST4 gene to outside databasesPrevious GC identifer: GC02M027035 |
Summaries
for OST4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OST4_HUMAN, P0C6T2Function: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (By similarity)
|
Genomic Views
for OST4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for OST4
Other transcription factors
Search SABiosciences Chromatin IP Primers for OST4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OST4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3OST4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M027294: view genomic region
(about GC identifiers)
Start:
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27,293,340 bp from pter |
End:
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27,294,641 bp from pter |
Size:
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1,302 bases |
Orientation:
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minus strand |
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Proteins
for OST4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OST4_HUMAN, P0C6T2 (See
protein sequence)Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Size: 37 amino acids; 4193 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in differentforms which contain at least RPN1/ribophorin-1, RPN2/ribophorin-2, OST48, DAD1, and either STT3A or STT3B (Bysimilarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=The singletransmembrane helix has a kink in the middle of the transmembrane span
1 PDB 3D structure from  and Proteopedia  for OST4:2LAT (3D)
Explore the universe of human proteins at neXtProt for OST4: NX_P0C6T2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C6T2
OST4 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001128165.1
ENSEMBL proteins: ENSP00000454411 ENSP00000457935 ENSP00000455716
Human Recombinant Protein Products for OST4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OST4 for ontologies About GeneDecksing
OST4 Antibody Products:
Assay Products for OST4: |
Protein
Domains /
Families
for OST4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OST4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C6T2ProtoNet protein and cluster: P0C6T2 UniProtKB/Swiss-Prot: OST4_HUMAN, P0C6T2Similarity: Belongs to the OST4 family |
Function
for OST4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OST4_HUMAN, P0C6T2Function: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OST4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OST4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OST4 (NM_001134693) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OST4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OST4 |
|
Pathways & Interactions
for OST4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OST4
|
Drugs & Compounds
for OST4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OST4
Search CenterWatch for drugs/clinical trials and news about OST4
|
Transcripts
for OST4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OST4 gene: NM_001134693.1 Unigene Cluster for OST4: Oligosaccharyltransferase 4 homolog (S. cerevisiae) Hs.502948 [show with all ESTs]Unigene Representative Sequence: BM4794123 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447619 ENST00000456793(uc002rig.3) ENST00000429985
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OST4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OST4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OST4 (NM_001134693) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OST4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OST4 |
Additional cDNA sequence: AL049447.1 BC105283.1 14 DOTS entries: DT.95146546 DT.91859766 DT.100868836 DT.101955417 DT.95146530 DT.86852089 DT.100039666 DT.319365 DT.95363656 DT.101954303 DT.100700993 DT.100746994 DT.85101859 DT.91658397
GeneLoc Exon Structure
|
Expression
for OST4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OST4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGCGTGT
About this image
Genevestigator expression for OST4
SOURCE GeneReport for Unigene cluster: Hs.502948
SABiosciences Custom PCR Arrays for OST4
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OST4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OST4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OST4 |
Orthologs
for OST4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OST4 gene from 2/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ost45 |
oligosaccharyltransferase 4 homolog (S. cerevisiae) |
-- |
|
5 (16.90 cM) 30905885 |
zebrafish
(Danio rerio) |
Actinopterygii |
ost46 |
oligosaccharyltransferase 4 homolog (S. cerevisiae... |
95(a) |
1 ↔ 1 |
4(443091-444737) |
ENSEMBL Gene Tree for OST4 (if available)
TreeFam Gene Tree for OST4 (if available) |
Paralogs
for OST4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OST4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OST4 (27293340 - 27294641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OST4: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for OST4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 OST4 for disorders About MalaCards
OST4 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: OST4 (3 documents)
Export disorders for OST4 gene to outside databases
|
Publications
for OST4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OST4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OST4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. (PubMed id 21609714)1, 2 Gayen S. and Kang C. (2011)
- An evolving view of the eukaryotic oligosaccharyltransferase. (PubMed id 16317064)1, 3 Kelleher D.J. and Gilmore R. (2006)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for OST4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OST4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing OST4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OST4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OST4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OST4 gene:
Search GeneIP for patents involving OST4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OST4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OST4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OST4 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OST4 | | OriGene 3'-UTR Clone for OST4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OST4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OST4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OST4 | | OriGene Custom Protein Services for OST4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OST4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OST4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OST4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OST4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OST4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OST4 |
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 |  |  |  | |
| | | | Search Tocris compounds for OST4 |
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 | | | OST4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for OST4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OST4 |
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