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OSR2 Gene

protein-coding   GIFtS: 52
GCID: GC08P099956

Odd-Skipped Related Transciption Factor 2

(Previous name: odd-skipped related 2 (Drosophila))
  See OSR2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Odd-Skipped Related Transciption Factor 21 2
Odd-Skipped Related 2 (Drosophila)1
Odd-Skipped Related 22
Protein Odd-Skipped-Related 22

External Ids:    HGNC: 158301   Entrez Gene: 1160392   Ensembl: ENSG000001649207   OMIM: 6112975   UniProtKB: Q8N2R03   
ORGUL members:         

Export aliases for OSR2 gene to outside databases

Previous GC identifers: GC08P098965 GC08P100030 GC08P099625 GC08P099913 GC08P099908 GC08P100025 GC08P095159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSR2 Gene:
OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004
(PubMed 15175245)).(supplied by OMIM, Mar 2008)

GeneCards Summary for OSR2 Gene:
OSR2 (odd-skipped related transciption factor 2) is a protein-coding gene. Diseases associated with OSR2 include blepharophimosis, ptosis, and epicanthus inversus syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZNF664.

Gene Wiki entry for OSR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSR2 gene promoter:
         Brachyury   AP-2gamma   Evi-1   C/EBPalpha   E47   POU2F1   POU2F1a   ARP-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSR2 promoter sequence
   Search Chromatin IP Primers for OSR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22.2

OSR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSR2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P099956:  view genomic region     (about GC identifiers)

Start:
99,956,631 bp from pter      End:
99,964,332 bp from pter
Size:
7,702 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSR2_HUMAN, Q8N2R0 (See protein sequence)
Recommended Name: Protein odd-skipped-related 2  
Size: 312 amino acids; 35513 Da
Secondary accessions: A8K626 Q96AM6 Q96LB6 Q96LB7
Alternative splicing: 2 isoforms:  Q8N2R0-1   Q8N2R0-2   

Explore the universe of human proteins at neXtProt for OSR2: NX_Q8N2R0

Explore proteomics data for OSR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135934.1  NP_001273770.1  NP_443727.2  

    ENSEMBL proteins: 
     ENSP00000430041   ENSP00000297565   ENSP00000402862   ENSP00000430780   ENSP00000430074  
     ENSP00000429910   ENSP00000414657  

    OSR2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OSR2

     
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    antibodies-online proteins for OSR2 (3 products) 

     
    antibodies-online peptides for OSR2

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    antibodies-online antibodies for OSR2 (21 products) 

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    antibodies-online kits for OSR2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N2R0

    ProtoNet protein and cluster: Q8N2R0

    UniProtKB/Swiss-Prot: OSR2_HUMAN, Q8N2R0
    Similarity: Belongs to the Odd C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Find genes that share domains with OSR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0043565sequence-specific DNA binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with OSR2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Osr2):
     craniofacial  digestive/alimentary  embryogenesis  hearing/vestibular/ear  mortality/aging 
     normal  skeleton  vision/eye 

    Find genes that share phenotypes with OSR2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSR2
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    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate OSR2:
    hsa-miR-587 hsa-let-7g* hsa-miR-3662 hsa-let-7a-2* hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidOSR2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSR2_HUMAN, Q8N2R0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with OSR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSR2
    Interactions:

        Search GeneGlobe Interaction Network for OSR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OSR2 (ENSP000002975654) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARCENSP000003490224STRING: ENSP00000349022
    RAE1ENSP000003602864STRING: ENSP00000360286
    NUPL2ENSP000002587424STRING: ENSP00000258742
    MSX1ENSP000003721704STRING: ENSP00000372170
    PAX9ENSP000003552454STRING: ENSP00000355245
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001656metanephros development ISS--
    GO:0001823mesonephros development ISS--
    GO:0002062chondrocyte differentiation ISS--
    GO:0008284positive regulation of cell proliferation ISS--

    Find genes that share ontologies with OSR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSR2 gene (3 alternative transcripts): 
    NM_001142462.2  NM_001286841.1  NM_053001.3  

    Unigene Cluster for OSR2:

    Odd-skipped related 2 (Drosophila)
    Hs.253247  [show with all ESTs]
    Unigene Representative Sequence: NM_001142462
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520791 ENST00000523368(uc010mbn.2) ENST00000297565(uc003yir.3 uc003yiq.3 uc011lgx.2)
    ENST00000520722 ENST00000521044 ENST00000435298 ENST00000522510 ENST00000520951
    ENST00000518199 ENST00000457907
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate OSR2:
    hsa-miR-587 hsa-let-7g* hsa-miR-3662 hsa-let-7a-2* hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidOSR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSR2
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    GenScript: all cDNA clones in your preferred vector (see all 3): OSR2 (NM_001012511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSR2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OSR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSR2
      QuantiTect SYBR Green Assays in human, mouse, rat OSR2
      QuantiFast Probe-based Assays in human, mouse, rat OSR2

    Additional mRNA sequence: 

    AK074518.1 AK291491.1 AK304654.1 AK310994.1 AY038072.1 AY038073.1 BC016936.1 

    7 DOTS entries:

    DT.100747260  DT.86852308  DT.120648186  DT.430058  DT.120648174  DT.75122971  DT.86852255 

    Selected AceView cDNA sequences (see all 80):

    BM725416 BI828928 W96481 BM699285 BM127023 BX101198 BM801782 AL043767 
    BM677843 AK074518 BG171510 BC016936 AI869010 CR593221 BM558631 BX112949 
    BP379796 BM669505 BF475680 AI271523 AA662302 AL708391 BE336705 W96514 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -     -                                 
    SP2:                    -     -                       -         
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for OSR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACATCAA
    OSR2 Expression
    About this image


    OSR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 10 entries
             S-shaped Body Proximal Cells S-shaped Body Proximal Segment
             Proximal Tubule
     
     Epithelial Cells
             Parietal Epithelial Cells Bowman's Capsule
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Process
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Branchial Arch 1
     
     Tooth (Integumentary System)
             Dental Papilla Cells Dental Papilla
    OSR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.253247
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OSR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osr21 , 5 odd-skipped related 2 (Drosophila)5
    odd-skipped related 21
    92.52(n)1
    97.64(a)1
      15 (14.46 cM)5
    1075871  NM_054049.21  NP_473390.11 
     352961125 
    chicken
    (Gallus gallus)
    Aves OSR21 odd-skipped related 2 (Drosophila) 82.75(n)
    92.16(a)
      771523  NM_001170344.1  NP_001163815.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSR26
    odd-skipped related transciption factor 2
    63(a)
    1 ↔ 1
    GL343394.1(925002-933922)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107052 Transcribed sequence with moderate similarity to protein more 81.39(n)    137733055 
    zebrafish
    (Danio rerio)
    Actinopterygii osr21 odd-skipped related 2 (Drosophila) 75.16(n)
    79.72(a)
      550389  NM_001017694.1  NP_001017694.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sob3 RNA polymerase II transcription factor 87(a)
    (best of 3)
      24A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea odd-23 C2H2-type zinc finger protein 81(a)
    (best of 2)
      X(6194914-6195754)   --


    ENSEMBL Gene Tree for OSR2 (if available)
    TreeFam Gene Tree for OSR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSR2 gene
    ZNF6642  OSR12  ZNF2392  
    Selected SIMAP similar genes for OSR2 using alignment to 5 protein entries:     OSR2_HUMAN (see all proteins) (see all similar genes):
    OSR1    ZNF78L1    ZNF841    ZNF182    ZNF552    ZNF782
    ZNF664    ZNF737    ZFP2    ZNF431    ZNF684    ZNF701
    ZNF713    ZNF720    ZNF816    ZNF90    ZNF99    A-328A3.4

    Find genes that share paralogs with OSR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSR2 (see all 124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864247921,2
    C--99956841(+) GTCTTC/TACACA 2 -- ut510--------
    rs1911927361,2
    --99957145(+) GTGCCA/CCAAAT 2 -- int10--------
    rs1821928361,2
    --99957230(+) CGACTC/TCCAGC 2 -- int10--------
    rs1130015911,2
    C,F--99957394(+) AAGCCT/AGGGTC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1420184291,2
    --99957609(+) AAACGC/TTCGGA 2 -- int10--------
    rs1866813721,2
    --99957627(+) GAAACA/GGCAAG 2 -- int10--------
    rs736999441,2
    C,F--99957854(+) GAAACG/AGAACC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1468972281,2
    C--99957991(+) TTAACA/GATTTT 2 -- int10--------
    rs22900321,2
    C,F,H--99958114(-) GAGATA/TAATGA 2 -- int18Minor allele frequency- T:0.02EA NS NA 2234
    rs1831116631,2
    C--99958143(+) TTTAGC/TAGATG 2 -- int10--------

    HapMap Linkage Disequilibrium report for OSR2 (99956631 - 99964332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OSR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6327CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSR2
    DNA2.0 Custom Variant and Variant Library Synthesis for OSR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611297    OMIM disorders: --

    1 disease for OSR2:    
    About MalaCards
    blepharophimosis, ptosis, and epicanthus inversus syndrome

    2 diseases from the University of Copenhagen DISEASES database for OSR2:
    blepharophimosis, ptosis, and epicanthus inversus syndrome     Cleft palate

    Find genes that share disorders with OSR2           About GenesLikeMe

    Genetic Association Database (GAD): OSR2
    Human Genome Epidemiology (HuGE) Navigator: OSR2 (1 document)

    Export disorders for OSR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSR2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OSR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. (PubMed id 15175245)1, 9 Lan Y....Jiang R. (Development 2004)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. Odd-skipped related 2 splicing variants show opposite transcriptional activity. (PubMed id 15670784)1 Kawai S....Amano A. (Biochem. Biophys. Res. Commun. 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. (PubMed id 11520675)1 Lan Y....Jiang R. (Mech. Dev. 2001)
    9. (PubMed id )2 
    10. Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2. (PubMed id 19429596)9 Laissue P....Veitia R.A. (J. Med. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116039 HGNC: 15830 AceView: OSR2 Ensembl:ENSG00000164920 euGenes: HUgn116039
    ECgene: OSR2 H-InvDB: OSR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSR2 gene:
    Search GeneIP for patents involving OSR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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