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Aliases for OSR2 Gene

Aliases for OSR2 Gene

  • Odd-Skipped Related Transciption Factor 2 2 3 5
  • Odd-Skipped Related 2 (Drosophila) 2

External Ids for OSR2 Gene

Previous GeneCards Identifiers for OSR2 Gene

  • GC08P098965
  • GC08P100030
  • GC08P099625
  • GC08P099913
  • GC08P099908
  • GC08P100025
  • GC08P095159
  • GC08P099956
  • GC08P098944

Summaries for OSR2 Gene

Entrez Gene Summary for OSR2 Gene

  • OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSR2 Gene

OSR2 (Odd-Skipped Related Transciption Factor 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is OSR1.

Gene Wiki entry for OSR2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSR2 Gene

Genomics for OSR2 Gene

Regulatory Elements for OSR2 Gene

Enhancers for OSR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OSR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSR2 Gene

Chromosome:
8
Start:
98,938,104 bp from pter
End:
98,952,110 bp from pter
Size:
14,007 bases
Orientation:
Plus strand

Genomic View for OSR2 Gene

Genes around OSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSR2 Gene

Proteins for OSR2 Gene

  • Protein details for OSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2R0-OSR2_HUMAN
    Recommended name:
    Protein odd-skipped-related 2
    Protein Accession:
    Q8N2R0
    Secondary Accessions:
    • A8K626
    • B4E3B7
    • Q96AM6
    • Q96LB6
    • Q96LB7

    Protein attributes for OSR2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSR2 Gene

Post-translational modifications for OSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSR2 Gene

Domains & Families for OSR2 Gene

Gene Families for OSR2 Gene

Protein Domains for OSR2 Gene

Suggested Antigen Peptide Sequences for OSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2R0

UniProtKB/Swiss-Prot:

OSR2_HUMAN :
  • Belongs to the Odd C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the Odd C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with OSR2: view

Function for OSR2 Gene

Gene Ontology (GO) - Molecular Function for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OSR2: view
genes like me logo Genes that share phenotypes with OSR2: view

Animal Models for OSR2 Gene

MGI Knock Outs for OSR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSR2 Gene

Localization for OSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSR2 Gene COMPARTMENTS Subcellular localization image for OSR2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with OSR2: view

Pathways & Interactions for OSR2 Gene

SuperPathways for OSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001656 metanephros development IEA,ISS --
GO:0001823 mesonephros development IEA,ISS --
GO:0002062 chondrocyte differentiation IEA,ISS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with OSR2: view

No data available for Pathways by source and SIGNOR curated interactions for OSR2 Gene

Drugs & Compounds for OSR2 Gene

No Compound Related Data Available

Transcripts for OSR2 Gene

Unigene Clusters for OSR2 Gene

Odd-skipped related 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for OSR2 Gene

GeneLoc Exon Structure for
OSR2
ECgene alternative splicing isoforms for
OSR2

Expression for OSR2 Gene

mRNA expression in normal human tissues for OSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSR2 Gene

This gene is overexpressed in Uterus (x7.3), Fallopian Tube (x6.9), Cervix - Ectocervix (x6.6), and Cervix - Endocervix (x5.4).

Protein differential expression in normal tissues from HIPED for OSR2 Gene

This gene is overexpressed in Plasma (47.7) and Adipocyte (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSR2 Gene



Protein tissue co-expression partners for OSR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSR2 Gene:

OSR2

SOURCE GeneReport for Unigene cluster for OSR2 Gene:

Hs.253247
genes like me logo Genes that share expression patterns with OSR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for OSR2 Gene

Orthologs for OSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSR2 34
  • 93.12 (n)
  • 98.02 (a)
OSR2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSR2 34
  • 95.62 (n)
  • 98.72 (a)
OSR2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osr2 34
  • 92.52 (n)
  • 97.64 (a)
Osr2 16
Osr2 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSR2 34
  • 99.54 (n)
  • 99.54 (a)
OSR2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osr2 34
  • 92.52 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves OSR2 34
  • 82.75 (n)
  • 92.16 (a)
OSR2 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSR2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osr2 34
  • 82.69 (n)
  • 95.83 (a)
Str.10705 34
zebrafish
(Danio rerio)
Actinopterygii osr2 34
  • 75.16 (n)
  • 79.72 (a)
osr2 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bowl 36
  • 82 (a)
odd 36
  • 78 (a)
sob 36
  • 87 (a)
bowl 35
  • 22 (a)
ManyToMany
drm 35
  • 51 (a)
ManyToMany
odd 35
  • 31 (a)
ManyToMany
sob 35
  • 28 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ODR1 34
  • 74.64 (n)
  • 89.86 (a)
worm
(Caenorhabditis elegans)
Secernentea odd-1 36
  • 60 (a)
odd-2 36
  • 81 (a)
odd-1 35
  • 35 (a)
ManyToMany
odd-2 35
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10104 34
Species where no ortholog for OSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSR2 Gene

ENSEMBL:
Gene Tree for OSR2 (if available)
TreeFam:
Gene Tree for OSR2 (if available)

Paralogs for OSR2 Gene

Paralogs for OSR2 Gene

(449) SIMAP similar genes for OSR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSR2: view

Variants for OSR2 Gene

Sequence variations from dbSNP and Humsavar for OSR2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2290032 -- 98,945,886(-) GAGAT(A/T)AATGA intron-variant
rs111991210 -- 98,948,836(+) ATTTT(G/T)AGGGC intron-variant
rs61744135 -- 98,949,233(+) CCACC(C/T)ATTCC reference, missense
rs143167020 -- 98,946,344(+) GGATC(G/T)CTGCA intron-variant, upstream-variant-2KB
rs113001591 -- 98,945,166(+) AAGCC(A/T)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSR2 Gene

Variant ID Type Subtype PubMed ID
esv3891446 CNV gain 25118596
nsv611809 CNV loss 21841781
nsv6327 CNV deletion 18451855

Variation tolerance for OSR2 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSR2 Gene

Disorders for OSR2 Gene

Relevant External Links for OSR2

Genetic Association Database (GAD)
OSR2
Human Genome Epidemiology (HuGE) Navigator
OSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSR2

No disorders were found for OSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSR2 Gene

Publications for OSR2 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. (PMID: 15175245) Lan Y. … Jiang R. (Development 2004) 3 22 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65

Products for OSR2 Gene

Sources for OSR2 Gene

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