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Aliases for OSR2 Gene

Aliases for OSR2 Gene

  • Odd-Skipped Related Transciption Factor 2 2 3 5
  • Odd-Skipped Related 2 (Drosophila) 2

External Ids for OSR2 Gene

Previous GeneCards Identifiers for OSR2 Gene

  • GC08P098965
  • GC08P100030
  • GC08P099625
  • GC08P099913
  • GC08P099908
  • GC08P100025
  • GC08P095159
  • GC08P099956
  • GC08P098944

Summaries for OSR2 Gene

Entrez Gene Summary for OSR2 Gene

  • OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSR2 Gene

OSR2 (Odd-Skipped Related Transciption Factor 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is OSR1.

Gene Wiki entry for OSR2 Gene

Additional gene information for OSR2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSR2 Gene

Genomics for OSR2 Gene

Regulatory Elements for OSR2 Gene

Enhancers for OSR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H099011 1.1 ENCODE 29.6 +75.2 75225 2 HDGF HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 VPS13B ENSG00000245970 OSR2 RPL30 ENSG00000271930 POP1 ENSG00000253562
GH08H098939 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +7.4 7383 12 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF143 ZNF207 OSR2 POP1 STK3 ENSG00000271930 ENSG00000229625
GH08H098973 0.9 Ensembl ENCODE 12.3 +36.0 35951 1 CTCF MAX RAD21 FOXA1 SMC3 ZBTB33 MAFK EMSY EZH2 STK3 OSR2 VPS13B LOC105375666 ENSG00000229625 GC08P098985
GH08H099891 1.1 ENCODE 9.8 +955.1 955115 2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 VPS13B PABPC1 OSR2 ANKRD46 COX6C GC08M099806
GH08H098824 1 ENCODE 9.9 -112.8 -112766 2 HDGF ARNT SIN3A GLIS2 ELK1 ZNF143 ZNF207 FOS ATF7 SP5 OSR2 RPL19P14 LOC643494
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSR2 Gene

Chromosome:
8
Start:
98,938,104 bp from pter
End:
98,952,110 bp from pter
Size:
14,007 bases
Orientation:
Plus strand

Genomic View for OSR2 Gene

Genes around OSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSR2 Gene

Proteins for OSR2 Gene

  • Protein details for OSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2R0-OSR2_HUMAN
    Recommended name:
    Protein odd-skipped-related 2
    Protein Accession:
    Q8N2R0
    Secondary Accessions:
    • A8K626
    • B4E3B7
    • Q96AM6
    • Q96LB6
    • Q96LB7

    Protein attributes for OSR2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSR2 Gene

Post-translational modifications for OSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSR2 Gene

Domains & Families for OSR2 Gene

Gene Families for OSR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OSR2 Gene

Suggested Antigen Peptide Sequences for OSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2R0

UniProtKB/Swiss-Prot:

OSR2_HUMAN :
  • Belongs to the Odd C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Odd C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with OSR2: view

Function for OSR2 Gene

Gene Ontology (GO) - Molecular Function for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OSR2: view
genes like me logo Genes that share phenotypes with OSR2: view

Animal Models for OSR2 Gene

MGI Knock Outs for OSR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OSR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSR2 Gene

Localization for OSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSR2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with OSR2: view

Pathways & Interactions for OSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001656 metanephros development ISS --
GO:0001823 mesonephros development ISS --
GO:0002062 chondrocyte differentiation ISS --
GO:0008284 positive regulation of cell proliferation ISS --
genes like me logo Genes that share ontologies with OSR2: view

No data available for Pathways by source and SIGNOR curated interactions for OSR2 Gene

Drugs & Compounds for OSR2 Gene

No Compound Related Data Available

Transcripts for OSR2 Gene

Unigene Clusters for OSR2 Gene

Odd-skipped related 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OSR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for OSR2 Gene

GeneLoc Exon Structure for
OSR2
ECgene alternative splicing isoforms for
OSR2

Expression for OSR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSR2 Gene

This gene is overexpressed in Uterus (x7.3), Fallopian Tube (x6.9), Cervix - Ectocervix (x6.6), and Cervix - Endocervix (x5.4).

Protein differential expression in normal tissues from HIPED for OSR2 Gene

This gene is overexpressed in Plasma (47.7) and Adipocyte (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSR2 Gene



Protein tissue co-expression partners for OSR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSR2 Gene:

OSR2

SOURCE GeneReport for Unigene cluster for OSR2 Gene:

Hs.253247

Evidence on tissue expression from TISSUES for OSR2 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with OSR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSR2 Gene

Orthologs for OSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSR2 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia OSR2 33 34
  • 95.62 (n)
cow
(Bos Taurus)
Mammalia OSR2 33 34
  • 93.12 (n)
mouse
(Mus musculus)
Mammalia Osr2 33 16 34
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Osr2 33
  • 92.52 (n)
chicken
(Gallus gallus)
Aves OSR2 33 34
  • 82.75 (n)
lizard
(Anolis carolinensis)
Reptilia OSR2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osr2 33
  • 82.69 (n)
Str.10705 33
zebrafish
(Danio rerio)
Actinopterygii osr2 33 34
  • 75.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta sob 35 34
  • 87 (a)
odd 35 34
  • 78 (a)
drm 34
  • 51 (a)
ManyToMany
bowl 34 35
  • 22 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ODR1 33
  • 74.64 (n)
worm
(Caenorhabditis elegans)
Secernentea odd-2 35 34
  • 81 (a)
odd-1 35 34
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10104 33
Species where no ortholog for OSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSR2 Gene

ENSEMBL:
Gene Tree for OSR2 (if available)
TreeFam:
Gene Tree for OSR2 (if available)

Paralogs for OSR2 Gene

Paralogs for OSR2 Gene

(449) SIMAP similar genes for OSR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSR2: view

Variants for OSR2 Gene

Sequence variations from dbSNP and Humsavar for OSR2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000129398 -- 98,944,489(+) TGCTG(C/G)TGGAG upstream-variant-2KB, utr-variant-5-prime
rs1000315856 -- 98,947,909(+) GGAGG(G/T)ATGTA intron-variant, upstream-variant-2KB
rs1000368330 -- 98,948,117(+) TAGGC(C/T)GAATC intron-variant, upstream-variant-2KB
rs1000467525 -- 98,942,977(+) TCTCC(A/G)TTTCA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000914058 -- 98,942,882(+) AAAAA(A/T)TCTGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OSR2 Gene

Variant ID Type Subtype PubMed ID
esv3891446 CNV gain 25118596
nsv611809 CNV loss 21841781
nsv6327 CNV deletion 18451855

Variation tolerance for OSR2 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSR2 Gene

Disorders for OSR2 Gene

Relevant External Links for OSR2

Genetic Association Database (GAD)
OSR2
Human Genome Epidemiology (HuGE) Navigator
OSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSR2

No disorders were found for OSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSR2 Gene

Publications for OSR2 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. (PMID: 15175245) Lan Y … Jiang R (Development (Cambridge, England) 2004) 3 22 60
  5. Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer. (PMID: 27143812) Li WH … Chang DM (Disease markers 2016) 3 60

Products for OSR2 Gene

Sources for OSR2 Gene

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