Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OSR1 Gene

protein-coding   GIFtS: 55
GCID: GC02M019551

Odd-Skipped Related Transciption Factor 1

(Previous names: odd-skipped (Drosophila) homolog, odd-skipped related 1...)
(Previous symbol: ODD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Odd-Skipped Related Transciption Factor 11 2     Odd-Skipped Homolog2
ODD1 2 3 5     Odd-Skipped Related 12
Odd-Skipped (Drosophila) Homolog1     Protein Odd-Skipped-Related 12
Odd-Skipped Related 1 (Drosophila)1     

External Ids:    HGNC: 81111   Entrez Gene: 1304972   Ensembl: ENSG000001438677   OMIM: 6088915   UniProtKB: Q8TAX03   

Export aliases for OSR1 gene to outside databases

Previous GC identifers: GC03P037496 GC03P038020 GC03P038167 GC03P038182 GC02M019473 GC02M019308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for OSR1 Gene:
OSR1 (odd-skipped related transciption factor 1) is a protein-coding gene. Diseases associated with OSR1 include pseudohypoaldosteronism, and cleft lip. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF664.

UniProtKB/Swiss-Prot: OSR1_HUMAN, Q8TAX0
Function: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development
(By similarity)

Gene Wiki entry for OSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSR1 gene promoter:
         Pax-2   Pax-2a   Nkx2-5   CREB   PPAR-gamma1   deltaCREB   USF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSR1 promoter sequence
   Search Chromatin IP Primers for OSR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24.1

OSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M019551:  view genomic region     (about GC identifiers)

Start:
19,551,246 bp from pter      End:
19,558,414 bp from pter
Size:
7,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OSR1_HUMAN, Q8TAX0 (See protein sequence)
Recommended Name: Protein odd-skipped-related 1  
Size: 266 amino acids; 29611 Da
Secondary accessions: B3KV97 D6W521

Explore the universe of human proteins at neXtProt for OSR1: NX_Q8TAX0

Explore proteomics data for OSR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660303.1  
    ENSEMBL proteins: 
     ENSP00000272223   ENSP00000441801  

    OSR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OSR1
    OriGene Protein Over-expression Lysate for OSR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OSR1
    GenScript Custom Purified and Recombinant Proteins Services for OSR1
    Novus Biologicals OSR1 Protein
    Novus Biologicals OSR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSR1

    OSR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OSR1
    Novus Biologicals OSR1 Antibodies
    Abcam antibodies for OSR1
    Cloud-Clone Corp. Antibodies for OSR1
    ThermoFisher Antibodies for OSR1
    LSBio Antibodies in human, mouse, rat for OSR1

    OSR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSR1
    Cloud-Clone Corp. CLIAs for OSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TAX0

    ProtoNet protein and cluster: Q8TAX0

    UniProtKB/Swiss-Prot: OSR1_HUMAN, Q8TAX0
    Similarity: Belongs to the Odd C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    OSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSR1_HUMAN, Q8TAX0
    Function: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development
    (By similarity)

         Genatlas biochemistry entry for OSR1:
    oxidative-stress responsive 1,homolog to the human SOK1 (Ste20/oxidant stress response kinase-1),widely expressed

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0046872metal ion binding IEA--
         
    OSR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for OSR1:
     Actin fiber cells  Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Osr1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  normal  renal/urinary system  reproductive system 
     respiratory system  skeleton  vision/eye 

    OSR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Osr1tm2.1Jian for OSR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OSR1:
    hsa-mir-21-5p (MIRT031058), hsa-mir-93-5p (MIRT028100)

    Block miRNA regulation of human, mouse, rat OSR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSR1 (see all 50):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-765 hsa-miR-4314 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidOSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSR1
    Predesigned siRNA for gene silencing in human, mouse, rat OSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSR1

    Clone
    Products:
         
    OriGene clones in human, mouse for OSR1 (see all 6)
    OriGene ORF clones in mouse, rat for OSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OSR1 (NM_004871)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OSR1_HUMAN, Q8TAX0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus ----

    OSR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSR1
    Interactions:

        GeneGlobe Interaction Network for OSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for OSR1 (Q8TAX03 ENSP000002722234) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR2P371733, ENSP000003519054I2D: score=1 STRING: ENSP00000351905
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    EGLN1Q9GZT93, ENSP000003556014I2D: score=1 STRING: ENSP00000355601
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    OXSR1ENSP000003117134STRING: ENSP00000311713
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001655urogenital system development ISS--
    GO:0001656metanephros development ----
    GO:0001657ureteric bud development ISS--
    GO:0001823mesonephros development ISS--

    OSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OSR1 gene: 
    NM_145260.2  

    Unigene Cluster for OSR1:

    Odd-skipped related 1 (Drosophila)
    Hs.123933  [show with all ESTs]
    Unigene Representative Sequence: BC025712
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272223(uc002rdc.3) ENST00000487581 ENST00000498844 ENST00000536433

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OSR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSR1 (see all 50):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-765 hsa-miR-4314 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidOSR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSR1
    Predesigned siRNA for gene silencing in human, mouse, rat OSR1
    Clone
    Products:
         
    OriGene clones in human, mouse for OSR1 (see all 6)
    OriGene ORF clones in mouse, rat for OSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OSR1 (NM_004871)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OSR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSR1
      QuantiTect SYBR Green Assays in human, mouse, rat OSR1
      QuantiFast Probe-based Assays in human, mouse, rat OSR1

    Additional mRNA sequence: 

    AB082568.1 AK074591.1 BC025712.1 

    3 DOTS entries:

    DT.97819389  DT.101969169  DT.121019937 

    Selected AceView cDNA sequences (see all 57):

    BM554048 BP376216 CR602655 AA375484 AL554059 AI391506 BP377338 AI435152 
    AB082568 AK122756 BI821849 BI752169 AW135691 BC025712 BX107943 BX350251 
    BU150441 BM888154 BI767609 AI273490 BM701439 BI819692 BQ898348 BM563981 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGACGCA
    OSR1 Expression
    About this image


    OSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 5 entries
             Intermediate Mesoderm Cells Intermediate Mesoderm
             Intermediate mesoderm-like cells
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Renal Collecting Duct System
             Renal progenitor cells
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Maxillary Process
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Interzone Cells Stylopod Synovial Joint
             Zeugopod
     
     Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm Cells Intermediate Mesoderm
    OSR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123933

    UniProtKB/Swiss-Prot: OSR1_HUMAN, Q8TAX0
    Tissue specificity: Expressed in adult colon, small intestine, prostate, testis, and fetal lung

        Custom PCR Arrays for OSR1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OSR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSR1
    QuantiTect SYBR Green Assays in human, mouse, rat OSR1
    QuantiFast Probe-based Assays in human, mouse, rat OSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for OSR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osr11 , 5 odd-skipped related 1 (Drosophila)1, 5 89.85(n)1
    97.74(a)1
      12 (4.05 cM)5
    239671  NM_011859.31  NP_035989.11 
     95744425 
    chicken
    (Gallus gallus)
    Aves OSR11 odd-skipped related 1 (Drosophila) 77.95(n)
    89.23(a)
      100316920  NM_001168709.1  NP_001162180.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSR16
    odd-skipped related transciption factor 1
    91(a)
    1 ↔ 1
    1(154288646-154320646)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136072 Xenopus laevis transcribed sequence with moderate similarity more 74.46(n)    BJ060115.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134992 Transcribed sequence with moderate similarity to protein more 79.78(n)    57092806 
    fruit fly
    (Drosophila melanogaster)
    Insecta fray3 embryonic cuticle biosynthesis (sensu
    Insecta) more
    56(a)   91B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.233   -- 63(a)   V(17956707-17967938)   --


    ENSEMBL Gene Tree for OSR1 (if available)
    TreeFam Gene Tree for OSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OSR1 gene
    ZNF6642  OSR22  ZNF2392  
    2 SIMAP similar genes for OSR1 using alignment to 1 protein entry:     OSR1_HUMAN:
    OSR2    ZNF24

    OSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OSR1 (see all 188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455587411,2
    C,F--19550923(-) AGAGTC/TTCTGG 1 -- int17Minor allele frequency- T:0.03NS NA 300
    rs454652971,2
    C,F--19550981(-) GCTGTG/AAGTTT 1 -- int15Minor allele frequency- A:0.01NS 178
    rs1925318051,2
    --19551022(+) ACCCTA/GTCCCT 1 -- int10--------
    rs455161911,2
    C,F--19551185(-) TGAGAG/CGACCA 1 -- int15Minor allele frequency- C:0.01NS 176
    rs681651181,2
    C--19551277(+) TAGTT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.00CSA 2
    rs355042481,2
    C--19551290(+) AAAAA-/A/AA  
            
    CTCCA
    2 -- ut312NA 4
    rs455086011,2
    C,F--19551340(-) ATATTG/ACGATT 1 -- ut315Minor allele frequency- A:0.01NS 188
    rs1901525421,2
    --19551614(+) ACTTCC/GTTGCC 1 -- ut310--------
    rs1817362271,2
    C--19551999(+) AGGGCC/TGCTGG 1 -- ut310--------
    rs344040711,2
    C,F--19552065(+) GAGCTC/GCTTCA 2 Q E mis14Minor allele frequency- G:0.00NA EU 5879

    HapMap Linkage Disequilibrium report for OSR1 (19551246 - 19558414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OSR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819849CNV Gain19587683

    Human Gene Mutation Database (HGMD): OSR1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing OSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608891    OMIM disorders: --

    6 diseases for OSR1:    
    About MalaCards
    pseudohypoaldosteronism    cleft lip    meningitis    hypoxia
    prostatitis    endotheliitis


    OSR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSR1
    Human Genome Epidemiology (HuGE) Navigator: OSR1 (3 documents)

    Export disorders for OSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OSR1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with OSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of OSR1 on human chromosome 2p24. (PubMed id 12119563)1, 2, 3 Katoh M. (Int. J. Mol. Med. 2002)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern. (PubMed id 2120051)1, 3 Coulter D.E....Schedl P. (EMBO J. 1990)
    8. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. (PubMed id 24191005)1 Sengupta S....Cobb M.H. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PubMed id 22228203)4 Aslibekyan S....Arnett D.K. (Pharmacogenet. Genomics 2012)
    10. A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function. (PubMed id 21821672)1 Zhang Z....Goodyer P. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 130497 HGNC: 8111 AceView: ODD Ensembl:ENSG00000143867 euGenes: HUgn130497
    ECgene: OSR1 H-InvDB: OSR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OSR1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/osr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OSR1 gene:
    Search GeneIP for patents involving OSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OSR1  
     OriGene qPCR primer pairs and template standards for OSR1   OriGene Protein Over-expression Lysate for OSR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OSR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OSR1   OriGene Purified Protein for OSR1  
     OriGene ORF clones in mouse, rat for OSR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OSR1   OriGene Custom Protein Services for OSR1  

     
     
     Block miRNA regulation of human, mouse, rat OSR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OSR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSR1 Predesigned siRNA for gene silencing in human, mouse, rat OSR1
     QuantiFast Probe-based Assays in human, mouse, rat OSR1 QuantiTect SYBR Green Assays in human, mouse, rat OSR1
     Custom PCR Arrays for OSR1 Search Chromatin IP Primers for OSR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSR1  GeneGlobe Interaction Network for OSR1
     Regulatory tfbs in OSR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OSR1 GenScript cDNA clones with any tag delivered in your preferred vector for OSR1
     GenScript Custom Assay Services for OSR1 GenScript Custom overexpressing Cell Line Services for OSR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OSR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OSR1 antibodies
     OSR1 proteins
     OSR1 lysates
     Antibodies for OSR1
     See all of Abcam's Antibodies, Kits and Proteins for OSR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OSR1
     Antibodies for OSR1
     ELISAs for OSR1
     CLIAs for OSR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for OSR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSR1
     SwitchGear 3'UTR luciferase reporter plasmids for OSR1
     SwitchGear Promoter luciferase reporter plasmids for OSR1
     ThermoFisher Antibodies for OSR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSR1
     LSBio Antibodies in human, mouse, rat for OSR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OSR1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4