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Aliases for OSR1 Gene

Aliases for OSR1 Gene

  • Odd-Skipped Related Transciption Factor 1 2 3
  • ODD 3 4
  • Odd-Skipped Related 1 (Drosophila) 2
  • Odd-Skipped (Drosophila) Homolog 2
  • Protein Odd-Skipped-Related 1 3
  • Odd-Skipped Related 1 3
  • Odd-Skipped Homolog 3
  • ODD, 6

External Ids for OSR1 Gene

Previous Symbols for OSR1 Gene

  • ODD

Summaries for OSR1 Gene

GeneCards Summary for OSR1 Gene

OSR1 (Odd-Skipped Related Transciption Factor 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is OSR2.

UniProtKB/Swiss-Prot for OSR1 Gene

  • Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.

Gene Wiki entry for OSR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSR1 Gene

Genomics for OSR1 Gene

Genomic Location for OSR1 Gene

Start:
19,351,485 bp from pter
End:
19,358,653 bp from pter
Size:
7,169 bases
Orientation:
Minus strand

Genomic View for OSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSR1 Gene

Regulatory Elements for OSR1 Gene

Proteins for OSR1 Gene

  • Protein details for OSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAX0-OSR1_HUMAN
    Recommended name:
    Protein odd-skipped-related 1
    Protein Accession:
    Q8TAX0
    Secondary Accessions:
    • B3KV97
    • D6W521

    Protein attributes for OSR1 Gene

    Size:
    266 amino acids
    Molecular mass:
    29611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OSR1 Gene

Proteomics data for OSR1 Gene at MOPED

Post-translational modifications for OSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSR1 Gene

Domains for OSR1 Gene

Gene Families for OSR1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for OSR1 Gene

UniProtKB/Swiss-Prot:

OSR1_HUMAN
Family:
  • Belongs to the Odd C2H2-type zinc-finger protein family.:
    • Q8TAX0
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q8TAX0
genes like me logo Genes that share domains with OSR1: view

Function for OSR1 Gene

Molecular function for OSR1 Gene

GENATLAS Biochemistry: oxidative-stress responsive 1,homolog to the human SOK1 (Ste20/oxidant stress response kinase-1),widely expressed
UniProtKB/Swiss-Prot Function: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.

Gene Ontology (GO) - Molecular Function for OSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OSR1: view
genes like me logo Genes that share phenotypes with OSR1: view

Animal Models for OSR1 Gene

MGI Knock Outs for OSR1:

miRNA for OSR1 Gene

miRTarBase miRNAs that target OSR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OSR1 Gene

Localization for OSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSR1 Gene COMPARTMENTS Subcellular localization image for OSR1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for OSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with OSR1: view

Pathways for OSR1 Gene

SuperPathways for OSR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001655 urogenital system development ISS --
GO:0001656 metanephros development --
GO:0001657 ureteric bud development ISS --
GO:0001823 mesonephros development ISS --
genes like me logo Genes that share ontologies with OSR1: view

No data available for Pathways by source for OSR1 Gene

Transcripts for OSR1 Gene

mRNA/cDNA for OSR1 Gene

Unigene Clusters for OSR1 Gene

Odd-skipped related 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSR1 Gene

No ASD Table

Relevant External Links for OSR1 Gene

GeneLoc Exon Structure for
OSR1
ECgene alternative splicing isoforms for
OSR1

Expression for OSR1 Gene

mRNA expression in normal human tissues for OSR1 Gene

mRNA differential expression in normal tissues according to GTEx for OSR1 Gene

This gene is overexpressed in Artery - Aorta (7.6), Bladder (6.1), and Esophagus - Muscularis (4.1).

SOURCE GeneReport for Unigene cluster for OSR1 Gene Hs.123933

mRNA Expression by UniProt/SwissProt for OSR1 Gene

Q8TAX0-OSR1_HUMAN
Tissue specificity: Expressed in adult colon, small intestine, prostate, testis, and fetal lung.
genes like me logo Genes that share expressions with OSR1: view

Orthologs for OSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSR1 36
  • 99.62 (n)
  • 99.62 (a)
OSR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSR1 36
  • 91.98 (n)
  • 98.87 (a)
OSR1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSR1 36
  • 90.6 (n)
  • 96.99 (a)
OSR1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osr1 36
  • 89.85 (n)
  • 97.74 (a)
Osr1 16
Osr1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSR1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osr1 36
  • 90.6 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves OSR1 36
  • 77.95 (n)
  • 89.23 (a)
OSR1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSR1 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13607 36
tropical clawed frog
(Silurana tropicalis)
Amphibia osr1 36
  • 74.26 (n)
  • 87.26 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13499 36
osr1 36
  • 71.96 (n)
  • 79.84 (a)
osr1 37
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bowl 37
  • 15 (a)
ManyToMany
drm 37
  • 44 (a)
ManyToMany
odd 37
  • 25 (a)
ManyToMany
sob 37
  • 21 (a)
ManyToMany
fray 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea odd-1 37
  • 34 (a)
ManyToMany
odd-2 37
  • 36 (a)
ManyToMany
Y59A8B.23 38
  • 63 (a)
Species with no ortholog for OSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSR1 Gene

ENSEMBL:
Gene Tree for OSR1 (if available)
TreeFam:
Gene Tree for OSR1 (if available)

Paralogs for OSR1 Gene

Paralogs for OSR1 Gene

Selected SIMAP similar genes for OSR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSR1: view

Variants for OSR1 Gene

Sequence variations from dbSNP and Humsavar for OSR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs851066 -- 19,352,628(-) TAAAC(A/G)GGTGG intron-variant
rs3036446 -- 19,354,390(-) tgtgt(-/GTG)AGATT intron-variant
rs5013667 -- 19,357,830(+) GCGCA(A/G)CTCCT intron-variant, upstream-variant-2KB
rs5829692 -- 19,354,423(+) CACAC(-/AC)GGGAT intron-variant
rs11676363 -- 19,355,284(+) CTCTC(C/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSR1 Gene

Variant ID Type Subtype PubMed ID
nsv819849 CNV Gain 19587683

Relevant External Links for OSR1 Gene

HapMap Linkage Disequilibrium report
OSR1
Human Gene Mutation Database (HGMD)
OSR1

Disorders for OSR1 Gene

Relevant External Links for OSR1

Genetic Association Database (GAD)
OSR1
Human Genome Epidemiology (HuGE) Navigator
OSR1
genes like me logo Genes that share disorders with OSR1: view

No data available for UniProtKB/Swiss-Prot for OSR1 Gene

Publications for OSR1 Gene

  1. Molecular cloning and characterization of OSR1 on human chromosome 2p24. (PMID: 12119563) Katoh M. (Int. J. Mol. Med. 2002) 2 3 4
  2. Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern. (PMID: 2120051) Coulter D.E. … Schedl P. (EMBO J. 1990) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for OSR1 Gene

  • Addgene plasmids for OSR1

Sources for OSR1 Gene

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