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OSMR Gene

protein-coding   GIFtS: 67
GCID: GC05P038845

Oncostatin M Receptor

Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oncostatin M Receptor1 2     IL-31 Receptor Subunit Beta2 3
OSMRB2 3 5     IL-31R Subunit Beta2 3
Interleukin-31 Receptor Subunit Beta2 3     PLCA12 5
IL-31R-beta2 3     Oncostatin-M Specific Receptor Beta Subunit2
IL-31RB2 3     Oncostatin-M-Specific Receptor Subunit Beta2

External Ids:    HGNC: 85071   Entrez Gene: 91802   Ensembl: ENSG000001456237   OMIM: 6017435   UniProtKB: Q996503   

Export aliases for OSMR gene to outside databases

Previous GC identifers: GC05P039029 GC05P039912 GC05P038846 GC05P038891 GC05P038881 GC05P038797


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSMR Gene:
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with
interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to
form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.
Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec
2009)

GeneCards Summary for OSMR Gene:
OSMR (oncostatin M receptor) is a protein-coding gene. Diseases associated with OSMR include amyloidosis, primary localized cutaneous, 1, and primary cutaneous amyloidosis. GO annotations related to this gene include oncostatin-M receptor activity and growth factor binding. An important paralog of this gene is IL6ST.

UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and
STAT5. Capable of transducing OSM-specific signaling events

Gene Wiki entry for OSMR (Oncostatin M receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSMR gene promoter:
         Sox5   AML1a   p300   Egr-1   ATF-2   COUP   CRE-BP1   COUP-TF   HSF2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OSMR promoter sequence
   Search Chromatin IP Primers for OSMR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSMR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.2

OSMR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSMR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P038845:  view genomic region     (about GC identifiers)

Start:
38,845,960 bp from pter      End:
38,945,698 bp from pter
Size:
99,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650 (See protein sequence)
Recommended Name: Oncostatin-M-specific receptor subunit beta precursor  
Size: 979 amino acids; 110509 Da
Subunit: Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31
receptor
Sequence caution: Sequence=AAH63468.1; Type=Erroneous termination; Positions=216; Note=Translated as Glu;
Sequence=AAH63468.1; Type=Frameshift; Positions=232, 288;
Secondary accessions: Q6P4E8 Q96QJ6
Alternative splicing: 2 isoforms:  Q99650-1   Q99650-2   

Explore the universe of human proteins at neXtProt for OSMR: NX_Q99650

Explore proteomics data for OSMR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys787
  • Glycosylation2 at Asn84, Asn163, Asn176, Asn326, Asn380, Asn446, Asn491, Asn580
  • Modification sites at PhosphoSitePlus

  • See OSMR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161827.1  NP_003990.1  

    ENSEMBL proteins: 
     ENSP00000422023   ENSP00000274276   ENSP00000423913   ENSP00000426729   ENSP00000422372  

    OSMR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for OSMR (OSM R beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OSMR
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OSMR
    GenScript Custom Purified and Recombinant Proteins Services for OSMR
    Novus Biologicals OSMR Proteins
    Novus Biologicals OSMR Lysate
    Sino Biological Recombinant Protein for OSMR
    Sino Biological Cell Lysate for OSMR
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSMR

    OSMR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for OSMR (OSM R beta)
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    OriGene Custom Antibody Services for OSMR
    Novus Biologicals OSMR Antibodies
    Abcam antibodies for OSMR
    Cloud-Clone Corp. Antibodies for OSMR
    Search ThermoFisher Antibodies for OSMR
    LSBio Antibodies in human, mouse, rat for OSMR

    OSMR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSMR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSMR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSMR
    Cloud-Clone Corp. CLIAs for OSMR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Oncostatin M-specific receptor, beta subunit
    IL-6 receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003529 Hematopoietin_rcpt_Gp130_CS

    Graphical View of Domain Structure for InterPro Entry Q99650

    ProtoNet protein and cluster: Q99650

    2 Blocks protein domains:
    IPB001005 Myb DNA-binding domain
    IPB003529 Long hematopoietin receptor


    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding (By similarity)
    Domain: The box 1 motif is required for JAK interaction and/or activation (By similarity)
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 4 fibronectin type-III domains


    OSMR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSMR_HUMAN, Q99650
    Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and
    STAT5. Capable of transducing OSM-specific signaling events
    Induction: Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004924contributes to oncostatin-M receptor activity IDA8999038
    GO:0005515protein binding ----
    GO:0019838growth factor binding IPI8999038
         
    OSMR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Osmr):
     hematopoietic system  no phenotypic analysis 

    OSMR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSMR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSMR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSMR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSMR

    miRNA
    Products:
        
    miRTarBase miRNAs that target OSMR:
    hsa-mir-335-5p (MIRT016997), hsa-mir-98-5p (MIRT027517)

    Block miRNA regulation of human, mouse, rat OSMR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSMR (see all 28):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-448 hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidOSMR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSMR
    Predesigned siRNA for gene silencing in human, mouse, rat OSMR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSMR

    Clone
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    OriGene clones in human, mouse for OSMR (see all 10)
    OriGene ORF clones in mouse, rat for OSMR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OSMR (NM_003999)
    Sino Biological Human cDNA Clone for OSMR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSMR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSMR

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OSMR
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSMR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSMR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSMR_HUMAN, Q99650: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005900oncostatin-M receptor complex IDA8999038

    OSMR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OSMR About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for OSMR (see all 7)
        OSM Pathway
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    2 GeneGo (Thomson Reuters) Pathways for OSMR
        Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response Oncostatin M signaling via MAPK in human cells

    1 BioSystems Pathway for OSMR
        Oncostatin M Signaling Pathway



    3 Kegg Pathways  (Kegg details for OSMR):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway


    OSMR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OSMR: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OSMR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for OSMR (Q996502, 3 ENSP000002742764) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044062, 3, ENSP000002292394MINT-8256382 I2D: score=2 STRING: ENSP00000229239
    IL6STP401893, ENSP000003387994I2D: score=2 STRING: ENSP00000338799
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    JAK1P234583, ENSP000003432044I2D: score=1 STRING: ENSP00000343204
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0007166cell surface receptor signaling pathway TAS8999038
    GO:0008283cell proliferation TAS8999038
    GO:0008284positive regulation of cell proliferation IGI8999038
    GO:0034097response to cytokine IDA8999038

    OSMR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSMR

    2 Novoseek inferred chemical compound relationships for OSMR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 86 22 10586060 (5), 18430728 (2), 10854424 (1), 15249728 (1) (see all 13)
    tyrosine 22.1 6 15935618 (2), 19594765 (1), 18430728 (1)



    OSMR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OSMR gene (2 alternative transcripts): 
    NM_001168355.1  NM_003999.2  

    Unigene Cluster for OSMR:

    Oncostatin M receptor
    Hs.120658  [show with all ESTs]
    Unigene Representative Sequence: NM_003999
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502536(uc003jlm.2) ENST00000274276(uc003jln.2 uc011cpj.2)
    ENST00000513831 ENST00000509237 ENST00000508882

    miRNA
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    Block miRNA regulation of human, mouse, rat OSMR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSMR (see all 28):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-448 hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidOSMR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OSMR
    Predesigned siRNA for gene silencing in human, mouse, rat OSMR
    Clone
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    OriGene clones in human, mouse for OSMR (see all 10)
    OriGene ORF clones in mouse, rat for OSMR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OSMR (NM_003999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSMR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSMR
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OSMR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSMR
      QuantiTect SYBR Green Assays in human, mouse, rat OSMR
      QuantiFast Probe-based Assays in human, mouse, rat OSMR

    Additional mRNA sequence: 

    AK304016.1 BC010943.1 BC063468.1 BC125209.1 BC125210.1 U60805.1 

    12 DOTS entries:

    DT.442570  DT.100782428  DT.97839952  DT.75128791  DT.75101557  DT.92424533  DT.95266801  DT.120872890 
    DT.210618  DT.92424535  DT.65284792  DT.95220494 

    Selected AceView cDNA sequences (see all 167):

    CR593298 BQ927403 AU279611 BQ773338 BQ012503 BM966841 AI475431 CK725065 
    AI092101 BU625290 CR623600 CN484130 BP337522 BU616931 BF838852 AL047252 
    BM995690 BM835319 AU156786 BM983121 BQ774644 CB242905 AI335261 AI553713 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSMR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                    -                                                                                 
    SP2:              -                                                                                                                                       
    SP3:              -                       -                                                                                                               
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for OSMR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSMR expression in normal human tissues (normalized intensities)      OSMR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCACGCA
    OSMR Expression
    About this image


    OSMR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
    OSMR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSMR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120658

    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
    Tissue specificity: Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and
    a variety of tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OSMR: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OSMR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSMR
    QuantiTect SYBR Green Assays in human, mouse, rat OSMR
    QuantiFast Probe-based Assays in human, mouse, rat OSMR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSMR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OSMR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osmr1 , 5 oncostatin M receptor1, 5 70.79(n)1
    55.57(a)1
      15 (3.30 cM)5
    184141  NM_011019.31  NP_035149.21 
     68135775 
    chicken
    (Gallus gallus)
    Aves OSMR1 oncostatin M receptor 50.84(n)
    35.34(a)
      427446  XM_004937203.1  XP_004937260.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSMR6
    oncostatin M receptor
    33(a)
    1 ↔ 1
    GL343241.1(85679-134567)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia osmr1 oncostatin M receptor 49.26(n)
    35.66(a)
      100485444  XM_004910448.1  XP_004910505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii osmr6
    oncostatin M receptor
    25(a)
    1 ↔ 1
    5(7777594-7811251) ENSDARG00000042903


    ENSEMBL Gene Tree for OSMR (if available)
    TreeFam Gene Tree for OSMR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSMR gene
    IL6ST2  CSF3R2  IL31RA2  LIFR2  IL12RB22  
    1 SIMAP similar gene for OSMR using alignment to 4 protein entries:     OSMR_HUMAN (see all proteins):
    LIFR

    OSMR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSMR (see all 1908)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658104
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)4--see VAR_0658102 D V mis40--------
    VAR_0658114
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)4--see VAR_0658112 P L mis40--------
    VAR_0658124
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)4--see VAR_0658122 K T mis40--------
    VAR_0435144
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)4--see VAR_0435142 I T mis40--------
    VAR_0435134
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)4--see VAR_0435132 G A mis40--------
    rs637505601,2
    Cpathogenic138874891(+) AACAGC/GATACT 2 A G mis10--------
    rs637505671,2
    Cpathogenic138876885(+) CAAAAC/TTGACA 2 T I mis10--------
    rs1908536701,2
    C--38796080(+) GTTAAC/TTTGAT 1 -- us2k10--------
    rs5405581,2
    C,F,O,H--38796261(+) AAAAAC/GAGATA 2 -- us2k111Minor allele frequency- G:0.17NS EA NA WA CSA 759
    rs1409598211,2
    C--38796314(+) AATTGC/TAATAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSMR (38845960 - 38945698 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OSMR (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2297322CNV Deletion18987734
    esv3111CNV Deletion18987735
    esv2730107CNV Deletion23290073
    esv1589521CNV Deletion17803354
    esv1469708CNV Deletion17803354
    dgv987e201CNV Deletion23290073
    esv1003705CNV Deletion20482838
    esv1255876CNV Deletion17803354
    esv2730109CNV Deletion23290073
    nsv4801CNV Insertion18451855

    Human Gene Mutation Database (HGMD): OSMR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSMR
    DNA2.0 Custom Variant and Variant Library Synthesis for OSMR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601743   
    OMIM disorders: 105250  
    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
  • Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by
    localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower
    legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching
    and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although
    many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as
    a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa
    of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen
    simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to
    produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen
    amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to
    represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate
    keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for OSMR (see all 34):    About MalaCards
    amyloidosis, primary localized cutaneous, 1    primary cutaneous amyloidosis    amyloidosis    cervical squamous cell carcinoma
    cblc    familial breast cancer    hyperparathyroidism    cervicitis
    pituitary adenoma    epididymitis    atopic dermatitis    lung adenocarcinoma
    dermatitis    inflammatory bowel disease    cervical cancer    adenoma
    melanoma    squamous cell carcinoma    cerebritis    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for OSMR:
    Atopic dermatitis     Amyloidosis

    OSMR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    4 Novoseek inferred disease relationships for OSMR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 51.2 8 10586060 (1), 11095488 (1), 17979974 (1), 10899931 (1) (see all 6)
    melanoma 26.9 5 19223499 (2), 17028186 (1)
    glioblastoma 24.3 1 17028186 (1)
    tumors 0 1 17028186 (1)

    Genetic Association Database (GAD): OSMR
    Human Genome Epidemiology (HuGE) Navigator: OSMR (4 documents)

    Export disorders for OSMR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSMR gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with OSMR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 3 Mosley B....Cosman D. (J. Biol. Chem. 1996)
    2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PubMed id 19690585)1, 2, 9 Lin M.W.... Tsai S.F. (Eur. J. Hum. Genet. 2010)
    3. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. (PubMed id 18179886)1, 2, 9 Arita K....McGrath J.A. (Am. J. Hum. Genet. 2008)
    4. Host determinants of HIV-1 control in African Americans. (PubMed id 20205591)1, 4 Pelak K.... . (J. Infect. Dis. 2010)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2 Dillon S.R.... Gross J.A. (Nat. Immunol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. (PubMed id 19223499)1, 9 Deng G....Kim Y.S. (Clin. Cancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9180 HGNC: 8507 AceView: OSMR Ensembl:ENSG00000145623 euGenes: HUgn9180
    ECgene: OSMR Kegg: 9180 H-InvDB: OSMR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSMR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OSMR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSMR gene:
    Search GeneIP for patents involving OSMR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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