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Aliases for OSMR Gene

Aliases for OSMR Gene

  • Oncostatin M Receptor 2 3
  • OSMRB 3 4 6
  • Interleukin-31 Receptor Subunit Beta 3 4
  • IL-31 Receptor Subunit Beta 3 4
  • IL-31R Subunit Beta 3 4
  • IL-31R-Beta 3 4
  • IL-31RB 3 4
  • PLCA1 3 6
  • Oncostatin-M Specific Receptor Beta Subunit 3
  • Oncostatin-M-Specific Receptor Subunit Beta 3

External Ids for OSMR Gene

Previous GeneCards Identifiers for OSMR Gene

  • GC05P039029
  • GC05P039912
  • GC05P038846
  • GC05P038891
  • GC05P038881
  • GC05P038797

Summaries for OSMR Gene

Entrez Gene Summary for OSMR Gene

  • This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for OSMR Gene

OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include amyloidosis, primary localized cutaneous, 1 and primary cutaneous amyloidosis. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include growth factor binding and oncostatin-M receptor activity. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for OSMR Gene

  • Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

Gene Wiki entry for OSMR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSMR Gene

Genomics for OSMR Gene

Regulatory Elements for OSMR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSMR Gene

Start:
38,845,858 bp from pter
End:
38,945,596 bp from pter
Size:
99,739 bases
Orientation:
Plus strand

Genomic View for OSMR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSMR Gene

Proteins for OSMR Gene

  • Protein details for OSMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99650-OSMR_HUMAN
    Recommended name:
    Oncostatin-M-specific receptor subunit beta
    Protein Accession:
    Q99650
    Secondary Accessions:
    • Q6P4E8
    • Q96QJ6

    Protein attributes for OSMR Gene

    Size:
    979 amino acids
    Molecular mass:
    110509 Da
    Quaternary structure:
    • Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.
    SequenceCaution:
    • Sequence=AAH63468.1; Type=Erroneous termination; Positions=216; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH63468.1; Type=Frameshift; Positions=232, 288; Evidence={ECO:0000305};

    Alternative splice isoforms for OSMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSMR Gene

Proteomics data for OSMR Gene at MOPED

Post-translational modifications for OSMR Gene

  • Ubiquitination at Lys787
  • Glycosylation at Asn84, Asn163, Asn176, Asn326, Asn380, Asn446, Asn491, and Asn580
  • Modification sites at PhosphoSitePlus

Other Protein References for OSMR Gene

No data available for DME Specific Peptides for OSMR Gene

Domains for OSMR Gene

Gene Families for OSMR Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for OSMR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99650

UniProtKB/Swiss-Prot:

OSMR_HUMAN :
  • Q99650
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 4 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with OSMR: view

Function for OSMR Gene

Molecular function for OSMR Gene

UniProtKB/Swiss-Prot Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
UniProtKB/Swiss-Prot Induction: Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004924 contributes_to oncostatin-M receptor activity IDA 8999038
GO:0005515 protein binding --
GO:0019838 growth factor binding IPI 8999038
genes like me logo Genes that share ontologies with OSMR: view

Phenotypes for OSMR Gene

genes like me logo Genes that share phenotypes with OSMR: view

Animal Model Products

CRISPR Products

miRNA for OSMR Gene

miRTarBase miRNAs that target OSMR

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSMR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSMR Gene

Localization for OSMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSMR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSMR Gene COMPARTMENTS Subcellular localization image for OSMR gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005900 oncostatin-M receptor complex IDA 8999038
GO:0016324 apical plasma membrane IDA 21912637
genes like me logo Genes that share ontologies with OSMR: view

Pathways for OSMR Gene

genes like me logo Genes that share pathways with OSMR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0007166 cell surface receptor signaling pathway --
GO:0008283 cell proliferation --
GO:0008284 positive regulation of cell proliferation IGI 8999038
GO:0034097 response to cytokine IDA 8999038
genes like me logo Genes that share ontologies with OSMR: view

Compounds for OSMR Gene

(2) Novoseek inferred chemical compound relationships for OSMR Gene

Compound -log(P) Hits PubMed IDs
gp 130 86 18
tyrosine 22.1 4
genes like me logo Genes that share compounds with OSMR: view

Transcripts for OSMR Gene

Unigene Clusters for OSMR Gene

Oncostatin M receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSMR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OSMR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSMR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for OSMR Gene

GeneLoc Exon Structure for
OSMR
ECgene alternative splicing isoforms for
OSMR

Expression for OSMR Gene

mRNA expression in normal human tissues for OSMR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSMR Gene

SOURCE GeneReport for Unigene cluster for OSMR Gene Hs.120658

mRNA Expression by UniProt/SwissProt for OSMR Gene

Q99650-OSMR_HUMAN
Tissue specificity: Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.
genes like me logo Genes that share expressions with OSMR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OSMR Gene

Orthologs for OSMR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSMR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSMR 35
  • 99.32 (n)
  • 99.08 (a)
OSMR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSMR 35
  • 80.89 (n)
  • 69.94 (a)
OSMR 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSMR 35
  • 81.16 (n)
  • 73.19 (a)
OSMR 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osmr 35
  • 70.79 (n)
  • 55.57 (a)
Osmr 16
Osmr 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSMR 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSMR 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osmr 35
  • 71.34 (n)
  • 58.16 (a)
chicken
(Gallus gallus)
Aves OSMR 35
  • 50.84 (n)
  • 35.34 (a)
OSMR 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSMR 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osmr 35
  • 49.26 (n)
  • 35.66 (a)
zebrafish
(Danio rerio)
Actinopterygii osmr 36
  • 25 (a)
OneToOne
Species with no ortholog for OSMR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSMR Gene

ENSEMBL:
Gene Tree for OSMR (if available)
TreeFam:
Gene Tree for OSMR (if available)

Paralogs for OSMR Gene

Paralogs for OSMR Gene

Selected SIMAP similar genes for OSMR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSMR: view

Variants for OSMR Gene

Sequence variations from dbSNP and Humsavar for OSMR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7318 -- 38,935,580(-) TTTGC(A/G)TGAAT utr-variant-3-prime
rs16351 -- 38,935,314(-) GGCCA(-/GTT)GTTGA utr-variant-3-prime, cds-indel
rs113378 -- 38,917,115(+) GAAAC(G/T)TGAGG intron-variant
rs168567 -- 38,935,083(+) gcctg(C/T)cttgg utr-variant-3-prime
rs168568 -- 38,924,814(+) GGTAT(C/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSMR Gene

Variant ID Type Subtype PubMed ID
nsv4801 CNV Insertion 18451855
esv1589521 CNV Deletion 17803354
esv1469708 CNV Deletion 17803354
esv2730107 CNV Deletion 23290073
esv3111 CNV Deletion 18987735
esv2297322 CNV Deletion 18987734
dgv987e201 CNV Deletion 23290073
esv2730109 CNV Deletion 23290073
esv1003705 CNV Deletion 20482838
esv1255876 CNV Deletion 17803354
nsv327488 CNV Loss 16902084

Relevant External Links for OSMR Gene

HapMap Linkage Disequilibrium report
OSMR
Human Gene Mutation Database (HGMD)
OSMR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSMR Gene

Disorders for OSMR Gene

(1) OMIM Diseases for OSMR Gene (601743)

UniProtKB/Swiss-Prot

OSMR_HUMAN
  • Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269 PubMed:18179886, ECO:0000269 PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for OSMR Gene

(4) Novoseek inferred disease relationships for OSMR Gene

Disease -log(P) Hits PubMed IDs
leukemia 51.2 6
melanoma 26.9 3
glioblastoma 24.3 1
tumors 0 1

Relevant External Links for OSMR

Genetic Association Database (GAD)
OSMR
Human Genome Epidemiology (HuGE) Navigator
OSMR
genes like me logo Genes that share disorders with OSMR: view

Publications for OSMR Gene

  1. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. (PMID: 18179886) Arita K. … McGrath J.A. (Am. J. Hum. Genet. 2008) 3 4 23
  2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PMID: 19690585) Lin M.W. … Tsai S.F. (Eur. J. Hum. Genet. 2010) 3 4 23
  3. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B. … Cosman D. (J. Biol. Chem. 1996) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PMID: 15184896) Dillon S.R. … Gross J.A. (Nat. Immunol. 2004) 3 4

Products for OSMR Gene

Sources for OSMR Gene

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