Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSMR Gene

protein-coding   GIFtS: 62
GCID: GC05P038845

oncostatin M receptor
 Explore 27 diseases affiliated with
OSMR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OSMR    

Aliases
for OSMR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Oncostatin M Receptor1 2     IL-31 Receptor Subunit Beta2 3
OSMRB1 2 3 5     IL-31R Subunit Beta2 3
Interleukin-31 Receptor Subunit Beta2 3     PLCA12
IL-31R-Beta1     Oncostatin-M Specific Receptor Beta Subunit2
IL-31RB2 3     Oncostatin-M-Specific Receptor Subunit Beta2

External Ids:    HGNC: 85071   Entrez Gene: 91802   Ensembl: ENSG000001456237   OMIM: 6017435   UniProtKB: Q996503   

Export aliases for OSMR gene to outside databases

Previous GC identifers: GC05P039029 GC05P039912 GC05P038846 GC05P038891 GC05P038881 GC05P038797


Summaries
for OSMR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OSMR:
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin
6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the
interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in
this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5.
Capable of transducing OSM-specific signaling events

Gene Wiki entry for OSMR (Oncostatin M receptor)


Genomic Views
for OSMR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSMR gene promoter:
         Sox5   AML1a   p300   Egr-1   ATF-2   COUP   CRE-BP1   COUP-TF   HSF2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OSMR promoter sequence
   Search SABiosciences Chromatin IP Primers for OSMR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSMR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.2

OSMR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSMR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P038845:  view genomic region     (about GC identifiers)

Start:
 38,845,960 bp from pter      End:
 38,945,698 bp from pter
Size:
 99,739 bases      Orientation:
 plus strand

Proteins
for OSMR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650 (See protein sequence)
Recommended Name: Oncostatin-M-specific receptor subunit beta precursor  
Size: 979 amino acids; 110509 Da
Subunit: Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31
receptor
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAH63468.1; Type=Erroneous termination; Positions=216; Note=Translated as Glu;
Sequence=AAH63468.1; Type=Frameshift; Positions=232, 288;
Secondary accessions: Q6P4E8 Q96QJ6
Alternative splicing: 2 isoforms:  Q99650-1   Q99650-2   

Explore the universe of human proteins at neXtProt for OSMR: NX_Q99650

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99650

    • OSMR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161827.1  NP_003990.1  

    ENSEMBL proteins: 
     ENSP00000422023   ENSP00000274276   ENSP00000423913   ENSP00000426729   ENSP00000422372  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for OSMR (OSM R beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: OSMR
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for OSMR 
    GenScript Custom Purified and Recombinant Proteins Services for OSMR
    Novus Biologicals OSMR Proteins
    Novus Biologicals OSMR Lysate
    Sino Biological Recombinant Protein for OSMR
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OSMR

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005900oncostatin-M receptor complex IDA8999038


    OSMR for ontologies           About GeneDecksing



    OSMR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for OSMR (OSM R beta)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OSMR 
    GenScript Custom Superior Antibodies Services for OSMR
    Novus Biologicals OSMR Antibodies
    Search for Antibodies for OSMR at Abcam  
    Uscn Antibodies for OSMR
    Search ThermoFisher Antibodies for OSMR

    Assay Products for OSMR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSMR
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for OSMR

    Protein Domains /
    Families
    for OSMR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OSMR for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003529 Hematopoietin_rcpt_Gp130_CS

    Graphical View of Domain Structure for InterPro Entry Q99650

    ProtoNet protein and cluster: Q99650

    2 Blocks protein families:
    IPB001005 Myb DNA-binding domain
    IPB003529 Long hematopoietin receptor


    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding (By similarity)
    Domain: The box 1 motif is required for JAK interaction and/or activation (By similarity)
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 4 fibronectin type-III domains


    Function
    for OSMR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
    Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5.
    Capable of transducing OSM-specific signaling events
    Induction: Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: OSMR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSMR
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate OSMR (see all 28):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-448 hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: OSMR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSMR (see all 7)
    OriGene shRNA RFP: OSMR
    OriGene siRNA: OSMR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSMR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OSMR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): OSMR (NM_003999)
    Sino Biological Human cDNA Clone for OSMR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSMR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSMR 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for OSMR
    Search LifeMap BioReagents cell lines for OSMR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSMR

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004924contributes to oncostatin-M receptor activity IDA8999038
    GO:0019838growth factor binding IPI8999038


    OSMR for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Osmr):
     hematopoietic system  no phenotypic analysis 

    OSMR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for OSMR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		Oncostatin M Signaling Pathway0.15
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    3Serine phosphorylation of STATs
    		Immune response Oncostatin M signaling via JAK-Stat in human cells0.29
    		Immune response_Oncostatin M signaling via JAK-Stat in human cells0.29
    4PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.26
    5Jak-STAT signaling pathway
    		Jak-STAT signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for OSMR
        Immune response Oncostatin M signaling via MAPK in human cells
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for OSMR (see all 7)
        OSM Pathway
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    2 GeneGo (Thomson Reuters) Pathways for OSMR
        Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response Oncostatin M signaling via MAPK in human cells

    1 BioSystems Pathway for OSMR 
        Oncostatin M Signaling Pathway


    2         Kegg Pathways  (Kegg details for OSMR):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    OSMR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSMR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for OSMR (Q996502, 3 ENSP000002742764) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044062, 3, ENSP000002292394MINT-8256382 I2D: score=2 STRING: ENSP00000229239
    IL6STP401893, ENSP000003387994I2D: score=2 STRING: ENSP00000338799
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    JAK1P234583, ENSP000003432044I2D: score=1 STRING: ENSP00000343204
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0007166cell surface receptor signaling pathway TAS8999038
    GO:0008283cell proliferation TAS8999038
    GO:0008284positive regulation of cell proliferation IGI8999038
    GO:0034097response to cytokine stimulus IDA8999038


    OSMR for ontologies           About GeneDecksing



    Drugs & Compounds
    for OSMR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OSMR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSMR
    2 Novoseek chemical compound relationships for OSMR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 86 22 10586060 (5), 18430728 (2), 10854424 (1), 15249728 (1) (see all 13)
    tyrosine 22.1 6 15935618 (2), 19594765 (1), 18430728 (1)

    Search CenterWatch for drugs/clinical trials and news about OSMR 

    Transcripts
    for OSMR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OSMR gene (2 alternative transcripts): 
    NM_001168355.1  NM_003999.2  

    Unigene Cluster for OSMR:

    Oncostatin M receptor
    Hs.120658  [show with all ESTs]
    Unigene Representative Sequence: NM_003999
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502536(uc003jlm.2) ENST00000274276(uc003jln.2 uc011cpj.2)
    ENST00000513831 ENST00000509237 ENST00000508882

    miRNA
    Products:             		 OriGene 3'-UTR Clone: OSMR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSMR
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate OSMR (see all 28):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-448 hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: OSMR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSMR (see all 7)
    OriGene shRNA RFP: OSMR
    OriGene siRNA: OSMR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSMR
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): OSMR (NM_003999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSMR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSMR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSMR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSMR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSMR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSMR

    Additional cDNA sequence: 

    AK304016.1 BC010943.1 BC063468.1 BC125209.1 BC125210.1 U60805.1 

    13 DOTS entries:

    DT.442570  DT.100782428  DT.97839952  DT.75128791  DT.75101557  DT.92424533  DT.95266801  DT.120872890 
    DT.210618  DT.92424535  DT.100749619  DT.65284792  DT.95220494 

    24/167 AceView cDNA sequences (see all 167):

    CR593298 BM983121 CK725065 AI092101 AL047252 CR623600 AI475431 BM966841 
    BU625290 AU279611 CN484130 BQ927403 BP337522 BM835319 BP346284 BE855824 
    BQ012503 CB242905 BU619548 AA614387 AU156786 BQ935479 BQ774644 BF838852 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSMR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                    -                                                                                 
    SP2:              -                                                                                                                                       
    SP3:              -                       -                                                                                                               
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for OSMR

    Expression
    for OSMR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSMR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGCACGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OSMR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverIntrahepatic Biliary TreeOval CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OSMR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSMR

    SOURCE GeneReport for Unigene cluster: Hs.120658

    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
    Tissue specificity: Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a
    variety of tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including OSMR: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSMR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSMR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSMR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSMR
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSMR

    Orthologs
    for OSMR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for OSMR gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OSMR1 oncostatin M receptor 50.94(n)
    35.7(a)    		   427446  XM_425020.3  XP_425020.3 
    lizard
    (Anolis carolinensis)    		 Reptilia OSMR6
    		 --
    		 33(a)
    		 1 ↔ 1
    		 GL343241.1(89931-121712)
    zebrafish
    (Danio rerio)    		 Actinopterygii osmr6
    lifra6
    (see all 4)    		 leukemia inhibitory factor receptor alpha a
    (see all 4)    		 24(a)
    23(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 5(7777594-7811251)
    5(7820162-7886515)


    ENSEMBL Gene Tree for OSMR (if available)
    TreeFam Gene Tree for OSMR (if available) 

    Paralogs
    for OSMR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OSMR gene
    CSF3R2  IL6ST2  IL31RA2  IL27RA2  LIFR2  IL12RB22  
    1 SIMAP similar gene for OSMR using alignment to 4 protein entries:     OSMR_HUMAN (see all proteins):
    LIFR

    OSMR for paralogs           About GeneDecksing



    Genomic Variants
    for OSMR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1585 NCBI SNPs in OSMR are shown (see all 1585)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs637505601,2
    		Cpathogenic38874891(+) AACAGC/GATACT 2 A G mis10--------
    rs637505671,2
    		Cpathogenic38876885(+) CAAAAC/TTGACA 2 T I mis10--------
    rs5405581,2
    		C,F,O,H,--38796261(+) AAAAAC/GAGATA 2 -- us2k111Minor allele frequency- G:0.17NS EA NA WA CSA 759
    rs4090111,2
    		C--38796659(+) TATTAG/AGGCCT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs799132821,2
    		F,--38796896(+) CCTTGC/TTTTTG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs133566241,2
    		C,--38797235(+) CTAAAC/TATAGA 2 -- us2k10--------
    rs58674341,2
    		C--38797393(+) gtctcAA/-aaaaa 2 -- us2k1 trp31Minor allele frequency- -:0.50NA 2
    rs133590391,2
    		C,F,--38797561(+) AAAAAT/AGGGGA 2 -- us2k11Minor allele frequency- A:0.09WA 118
    rs22920171,2
    		C,F,--38798127(+) CCGGGC/TCGCCT 2 -- ut511Minor allele frequency- T:0.10EA 1476
    rs771501571,2
    		F,--38798320(+) AAAGAA/CTCCGA 2 -- ut51 int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for OSMR (38845960 - 38945698 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for OSMR
         4 Indels: 27935 46883 27936 42443
    Human Gene Mutation Database (HGMD): OSMR

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSMR
    DNA2.0 Custom Variant and Variant Library Synthesis for OSMR

    Disorders / Diseases
    for OSMR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OSMR for disorders           About GeneDecksing

    OMIM gene information: 601743   
    OMIM disorders: 105250  
    UniProtKB/Swiss-Prot: OSMR_HUMAN, Q99650
  • Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1) [MIM:105250]; also
    • known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary
    amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching
    (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may
    be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate
    keratin filaments, serum amyloid P component, and deposition of immunoglobulins

    20/27 diseases for OSMR (see all 27):    About MalaCards
    amyloidosis    primary cutaneous amyloidosis    cervical squamous cell carcinoma    squamous cell carcinoma
    inflammatory bowel disease    atopic dermatitis    pituitary adenoma    familial breast cancer
    cblc    dermatitis    cervicitis    breast cancer
    lung adenocarcinoma    adenoma    ovarian carcinoma    cervical cancer
    colon cancer    ovarian cancer    gastric cancer    colorectal cancer

    4 Novoseek disease relationships for OSMR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 51.2 8 10586060 (1), 11095488 (1), 17979974 (1), 10899931 (1) (see all 6)
    melanoma 26.9 5 19223499 (2), 17028186 (1)
    glioblastoma 24.3 1 17028186 (1)
    tumors 0 1 17028186 (1)

    Human Genome Epidemiology (HuGE) Navigator: OSMR (4 documents)

    Export disorders for OSMR gene to outside databases

    Publications
    for OSMR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSMR gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with OSMR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 3 Mosley B....Cosman D. (1996)
    2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PubMed id 19690585)1, 2, 9 Lin M.W....Tsai S.F. (2010)
    3. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. (PubMed id 18179886)1, 2, 9 Arita K....McGrath J.A. (2008)
    4. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2 Dillon S.R.... Gross J.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. (PubMed id 19223499)1, 9 Deng G....Kim Y.S. (2009)
    7. Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. (PubMed id 10586060)1, 9 Hermanns H.M....Behrmann I. (1999)
    8. Promoter DNA methylation of oncostatin m receptor-bet a as a novel diagnostic and therapeutic marker in colon cancer. (PubMed id 19662090)1, 9 Kim M.S....Sidransky D. (2009)
    9. Oncostatin M pathway plays a major role in the renal acute phase response. (PubMed id 19158344)1, 9 Luyckx V.A....Mueller T.F. (2009)
    10. Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation. (PubMed id 18430728)1, 9 Hintzen C....Hermanns H.M. (2008)

    External Searches for OSMR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OSMR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9180 HGNC: 8507 AceView: OSMR Ensembl:ENSG00000145623 euGenes: HUgn9180
    ECgene: OSMR Kegg: 9180 H-InvDB: OSMR

    Other Databases showing OSMR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OSMR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSMR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OSMR Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for OSMR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OSMR gene:
    Search GeneIP for patents involving OSMR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OSMR gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for OSMR (OSM R beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for OSMR (OSM R beta)  
     Browse OriGene Antibodies   OriGene shRNA RFP for OSMR  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSMR   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSMR  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for OSMR   OriGene 3'-UTR Clone for OSMR  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSMR  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for OSMR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OSMR   OriGene Custom Protein Services for OSMR  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSMR
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSMR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSMR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSMR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSMR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSMR
     GenScript Custom Purified and Recombinant Proteins Services for OSMR GenScript cDNA clones with any tag delivered in your preferred vector for OSMR
     GenScript Custom Assay Services for OSMR GenScript Custom Superior Antibodies Services for OSMR
     GenScript Custom overexpressing Cell Line Services for OSMR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OSMR promoter
     Search Chromatin IP Primers for OSMR
     RT2 qPCR Primer Assay in human, mouse, rat OSMR
     GNC Network for OSMR
     SABiosciences PCR Arrays including human, mouse, rat OSMR
     Search Tocris compounds for OSMR
     Proteins and Antibodies for OSMR
     cDNA Clones for OSMR
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OSMR antibodies
     OSMR proteins
     OSMR lysates
     Search for Antibodies for OSMR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for OSMR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     OSMR Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for OSMR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSMR
     SwitchGear 3'UTR luciferase reporter plasmids for OSMR
     SwitchGear Promoter luciferase reporter plasmids for OSMR
     Search ThermoFisher Antibodies for OSMR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSMR
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      OSMR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4