Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSMR Gene

Aliases for OSMR Gene

  • Oncostatin M Receptor 2 3 5
  • Interleukin-31 Receptor Subunit Beta 3 4
  • IL-31 Receptor Subunit Beta 3 4
  • IL-31R Subunit Beta 3 4
  • IL-31R-Beta 3 4
  • IL-31RB 3 4
  • OSMRB 3 4
  • Oncostatin-M Specific Receptor Beta Subunit 3
  • PLCA1 3

External Ids for OSMR Gene

Previous GeneCards Identifiers for OSMR Gene

  • GC05P039029
  • GC05P039912
  • GC05P038846
  • GC05P038891
  • GC05P038881
  • GC05P038797

Summaries for OSMR Gene

Entrez Gene Summary for OSMR Gene

  • This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for OSMR Gene

OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include amyloidosis, primary localized cutaneous, 1 and primary cutaneous amyloidosis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include growth factor binding and oncostatin-M receptor activity. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for OSMR Gene

  • Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

Gene Wiki entry for OSMR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSMR Gene

Genomics for OSMR Gene

Regulatory Elements for OSMR Gene

Promoters for OSMR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSMR on UCSC Golden Path with GeneCards custom track

Genomic Location for OSMR Gene

Chromosome:
5
Start:
38,845,858 bp from pter
End:
38,945,596 bp from pter
Size:
99,739 bases
Orientation:
Plus strand

Genomic View for OSMR Gene

Genes around OSMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSMR Gene

Proteins for OSMR Gene

  • Protein details for OSMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99650-OSMR_HUMAN
    Recommended name:
    Oncostatin-M-specific receptor subunit beta
    Protein Accession:
    Q99650
    Secondary Accessions:
    • Q6P4E8
    • Q96QJ6

    Protein attributes for OSMR Gene

    Size:
    979 amino acids
    Molecular mass:
    110509 Da
    Quaternary structure:
    • Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.
    SequenceCaution:
    • Sequence=AAH63468.1; Type=Erroneous termination; Positions=216; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH63468.1; Type=Frameshift; Positions=232, 288; Evidence={ECO:0000305};

    Alternative splice isoforms for OSMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSMR Gene

Proteomics data for OSMR Gene at MOPED

Post-translational modifications for OSMR Gene

  • Ubiquitination at Lys 787
  • Glycosylation at Asn 84, Asn 163, Asn 176, Asn 326, Asn 380, Asn 446, Asn 491, and Asn 580
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for OSMR Gene

Domains & Families for OSMR Gene

Suggested Antigen Peptide Sequences for OSMR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99650

UniProtKB/Swiss-Prot:

OSMR_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 4 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with OSMR: view

Function for OSMR Gene

Molecular function for OSMR Gene

UniProtKB/Swiss-Prot Function:
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
UniProtKB/Swiss-Prot Induction:
Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IEA --
GO:0004924 contributes_to oncostatin-M receptor activity IDA 8999038
GO:0019838 growth factor binding IPI 8999038
genes like me logo Genes that share ontologies with OSMR: view
genes like me logo Genes that share phenotypes with OSMR: view

Human Phenotype Ontology for OSMR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for OSMR Gene

MGI Knock Outs for OSMR:

Animal Model Products

miRNA for OSMR Gene

miRTarBase miRNAs that target OSMR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OSMR Gene

Localization for OSMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSMR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSMR Gene COMPARTMENTS Subcellular localization image for OSMR gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005900 oncostatin-M receptor complex IDA 8999038
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OSMR: view

Pathways & Interactions for OSMR Gene

genes like me logo Genes that share pathways with OSMR: view

SIGNOR curated interactions for OSMR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for OSMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038165 oncostatin-M-mediated signaling pathway IMP 8999038
genes like me logo Genes that share ontologies with OSMR: view

Drugs & Compounds for OSMR Gene

(1) Drugs for OSMR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for OSMR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OSMR: view

Transcripts for OSMR Gene

Unigene Clusters for OSMR Gene

Oncostatin M receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSMR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for OSMR Gene

GeneLoc Exon Structure for
OSMR
ECgene alternative splicing isoforms for
OSMR

Expression for OSMR Gene

mRNA expression in normal human tissues for OSMR Gene

Protein differential expression in normal tissues from HIPED for OSMR Gene

This gene is overexpressed in Plasma (30.2), Serum (22.9), and Adrenal (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSMR Gene



SOURCE GeneReport for Unigene cluster for OSMR Gene Hs.120658

mRNA Expression by UniProt/SwissProt for OSMR Gene

Q99650-OSMR_HUMAN
Tissue specificity: Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.
genes like me logo Genes that share expression patterns with OSMR: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for OSMR Gene

Orthologs for OSMR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSMR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSMR 35
  • 80.89 (n)
  • 69.94 (a)
OSMR 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSMR 35
  • 81.16 (n)
  • 73.19 (a)
OSMR 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osmr 35
  • 70.79 (n)
  • 55.57 (a)
Osmr 16
Osmr 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSMR 35
  • 99.32 (n)
  • 99.08 (a)
OSMR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osmr 35
  • 71.34 (n)
  • 58.16 (a)
oppossum
(Monodelphis domestica)
Mammalia OSMR 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSMR 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSMR 35
  • 50.84 (n)
  • 35.34 (a)
OSMR 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSMR 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osmr 35
  • 49.26 (n)
  • 35.66 (a)
zebrafish
(Danio rerio)
Actinopterygii osmr 36
  • 25 (a)
OneToOne
Species with no ortholog for OSMR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSMR Gene

ENSEMBL:
Gene Tree for OSMR (if available)
TreeFam:
Gene Tree for OSMR (if available)

Paralogs for OSMR Gene

Paralogs for OSMR Gene

(1) SIMAP similar genes for OSMR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSMR: view

Variants for OSMR Gene

Sequence variations from dbSNP and Humsavar for OSMR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17855841 - 38,884,036(+) ATAAA(G/T)GGACA nc-transcript-variant, reference, missense
rs10941412 - 38,919,056(+) ACCCC(A/C/G)AAAAC nc-transcript-variant, reference, missense
rs2278329 - 38,921,686(+) CTGGA(A/G)ATGTT nc-transcript-variant, reference, missense
rs3749737 - 38,933,310(+) CAAAC(C/T)CAGTA intron-variant, reference, missense
rs34675408 - 38,883,969(+) ATTCA(G/T)GGAGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OSMR Gene

Variant ID Type Subtype PubMed ID
nsv4801 CNV Insertion 18451855
esv1589521 CNV Deletion 17803354
esv1469708 CNV Deletion 17803354
esv2730107 CNV Deletion 23290073
esv3111 CNV Deletion 18987735
esv2297322 CNV Deletion 18987734
dgv987e201 CNV Deletion 23290073
esv2730109 CNV Deletion 23290073
esv1003705 CNV Deletion 20482838
esv1255876 CNV Deletion 17803354
nsv327488 CNV Loss 16902084

Variation tolerance for OSMR Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.21; 84.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSMR Gene

HapMap Linkage Disequilibrium report
OSMR
Human Gene Mutation Database (HGMD)
OSMR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSMR Gene

Disorders for OSMR Gene

MalaCards: The human disease database

(20) MalaCards diseases for OSMR Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis, primary localized cutaneous, 1
  • primary cutaneous amyloidosis
primary cutaneous amyloidosis
  • familial primary localized cutaneous amyloidosis
amyloidosis
  • amyloid disease
breast ductal adenoma
fox fordyce disease
  • fox-fordyce disease
- elite association - COSMIC cancer census association via MalaCards
Search OSMR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OSMR_HUMAN
  • Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269 PubMed:18179886, ECO:0000269 PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for OSMR

Genetic Association Database (GAD)
OSMR
Human Genome Epidemiology (HuGE) Navigator
OSMR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSMR
genes like me logo Genes that share disorders with OSMR: view

No data available for Genatlas for OSMR Gene

Publications for OSMR Gene

  1. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B. … Cosman D. (J. Biol. Chem. 1996) 2 3 4 67
  2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PMID: 19690585) Lin M.W. … Tsai S.F. (Eur. J. Hum. Genet. 2010) 3 23
  3. The molecular skin pathology of familial primary localized cutaneous amyloidosis. (PMID: 20507362) Tanaka A. … McGrath J.A. (Exp. Dermatol. 2010) 3 23
  4. Oncostatin M pathway plays a major role in the renal acute phase response. (PMID: 19158344) Luyckx V.A. … Mueller T.F. (Am. J. Physiol. Renal Physiol. 2009) 3 23
  5. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. (PMID: 19223499) Deng G. … Kim Y.S. (Clin. Cancer Res. 2009) 3 23

Products for OSMR Gene

Sources for OSMR Gene

Back to Top

Content