External Ids for OSM Gene
Previous GeneCards Identifiers for OSM Gene
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for OSM Gene
OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include indolent myeloma and chronic eosinophilic leukemia. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include cytokine activity and oncostatin-M receptor binding.
UniProtKB/Swiss-Prot for OSM Gene
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).