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Aliases for OSM Gene

Aliases for OSM Gene

  • Oncostatin M 2 3

External Ids for OSM Gene

Previous GeneCards Identifiers for OSM Gene

  • GC22M027354
  • GC22M028983
  • GC22M030658
  • GC22M013620

Summaries for OSM Gene

Entrez Gene Summary for OSM Gene

  • Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSM Gene

OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include indolent myeloma and chronic eosinophilic leukemia. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include cytokine activity and oncostatin-M receptor binding.

UniProtKB/Swiss-Prot for OSM Gene

  • Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Gene Wiki entry for OSM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSM Gene

Genomics for OSM Gene

Regulatory Elements for OSM Gene

Genomic Location for OSM Gene

Chromosome:
22
Start:
30,262,826 bp from pter
End:
30,266,840 bp from pter
Size:
4,015 bases
Orientation:
Minus strand

Genomic View for OSM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSM Gene

Proteins for OSM Gene

  • Protein details for OSM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13725-ONCM_HUMAN
    Recommended name:
    Oncostatin-M
    Protein Accession:
    P13725
    Secondary Accessions:
    • Q6FHP8
    • Q9UCP6

    Protein attributes for OSM Gene

    Size:
    252 amino acids
    Molecular mass:
    28484 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OSM Gene

neXtProt entry for OSM Gene

Proteomics data for OSM Gene at MOPED

Post-translational modifications for OSM Gene

  • Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
  • Glycosylation at Asn 100 and Asn 217
  • Modification sites at PhosphoSitePlus

Other Protein References for OSM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for OSM (Oncostatin M/OSM)

No data available for DME Specific Peptides for OSM Gene

Domains & Families for OSM Gene

Suggested Antigen Peptide Sequences for OSM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13725

UniProtKB/Swiss-Prot:

ONCM_HUMAN :
  • Belongs to the LIF/OSM family.
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with OSM: view

No data available for Gene Families for OSM Gene

Function for OSM Gene

Molecular function for OSM Gene

GENATLAS Biochemistry:
oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes
UniProtKB/Swiss-Prot Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

LifeMap Function Summary for OSM Gene

During embryonic development, OSM as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 8999038
GO:0005147 oncostatin-M receptor binding IPI 8999038
GO:0008083 growth factor activity IDA 8999038
genes like me logo Genes that share ontologies with OSM: view
genes like me logo Genes that share phenotypes with OSM: view

Animal Models for OSM Gene

MGI Knock Outs for OSM:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for OSM Gene

Localization for OSM Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSM Gene COMPARTMENTS Subcellular localization image for OSM gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with OSM: view

Pathways & Interactions for OSM Gene

genes like me logo Genes that share pathways with OSM: view

PCR Array Products

SIGNOR curated interactions for OSM Gene

Activates:

Gene Ontology (GO) - Biological Process for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0006955 immune response IEA --
GO:0007275 multicellular organismal development TAS 1717982
GO:0007422 peripheral nervous system development IEA --
GO:0008283 cell proliferation TAS 1542793
genes like me logo Genes that share ontologies with OSM: view

Drugs & Compounds for OSM Gene

(25) Drugs for OSM Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 145
Dexamethasone Approved, Investigational Pharma Agonist 1806
Estradiol Approved, Investigational Pharma Sex hormone 1057
Filgrastim Approved Pharma 0
Hyaluronan Approved Pharma 328

(31) Additional Compounds for OSM Gene - From: NovoSeek

genes like me logo Genes that share compounds with OSM: view

Transcripts for OSM Gene

mRNA/cDNA for OSM Gene

Unigene Clusters for OSM Gene

Oncostatin M:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSM Gene

No ASD Table

Relevant External Links for OSM Gene

GeneLoc Exon Structure for
OSM
ECgene alternative splicing isoforms for
OSM

Expression for OSM Gene

mRNA expression in normal human tissues for OSM Gene

mRNA differential expression in normal tissues according to GTEx for OSM Gene

This gene is overexpressed in Whole Blood (x37.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSM Gene



SOURCE GeneReport for Unigene cluster for OSM Gene Hs.248156

genes like me logo Genes that share expression patterns with OSM: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OSM Gene

Orthologs for OSM Gene

This gene was present in the common ancestor of mammals.

Orthologs for OSM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSM 36
  • 99 (a)
OneToOne
OSM 35
  • 99.6 (n)
  • 99.21 (a)
mouse
(Mus musculus)
Mammalia Osm 36
  • 45 (a)
OneToOne
Osm 16
Osm 35
  • 64.75 (n)
  • 51.2 (a)
dog
(Canis familiaris)
Mammalia OSM 36
  • 62 (a)
OneToOne
OSM 35
  • 77.07 (n)
  • 66.24 (a)
cow
(Bos Taurus)
Mammalia OSM 36
  • 55 (a)
OneToOne
OSM 35
  • 69.34 (n)
  • 55.66 (a)
rat
(Rattus norvegicus)
Mammalia Osm 35
  • 66.19 (n)
  • 50.95 (a)
Species with no ortholog for OSM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSM Gene

ENSEMBL:
Gene Tree for OSM (if available)
TreeFam:
Gene Tree for OSM (if available)

Paralogs for OSM Gene

No data available for Paralogs for OSM Gene

Variants for OSM Gene

Sequence variations from dbSNP and Humsavar for OSM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1476576 -- 30,264,528(+) CAAGT(A/C)AGCCT intron-variant
rs2070889 -- 30,263,577(-) CATGG(C/T)CGGGC utr-variant-3-prime
rs2070890 -- 30,263,547(-) CTCCC(C/T)GAGGC utr-variant-3-prime
rs5763918 -- 30,265,195(+) ACAGA(C/T)GGGAG intron-variant
rs5763919 - 30,266,774(+) GCAGC(A/G)TCCTC reference, missense, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OSM Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
dgv4954n71 CNV Loss 21882294
nsv914970 CNV Loss 21882294
nsv834174 CNV Gain+Loss 17160897
dgv4955n71 CNV Loss 21882294

Variation tolerance for OSM Gene

Residual Variation Intolerance Score: 76.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSM Gene

HapMap Linkage Disequilibrium report
OSM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSM Gene

Disorders for OSM Gene

MalaCards: The human disease database

(4) MalaCards diseases for OSM Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
indolent myeloma
  • indolent multiple myeloma
chronic eosinophilic leukemia
osteochondrosis
  • juvenile osteochondrosis of tibial tubercle
kaposi sarcoma
  • kaposi's sarcoma
- elite association
Search OSM in MalaCards View complete list of genes associated with diseases

Relevant External Links for OSM

Genetic Association Database (GAD)
OSM
Human Genome Epidemiology (HuGE) Navigator
OSM
Tumor Gene Database (TGDB):
OSM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSM
genes like me logo Genes that share disorders with OSM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSM Gene

Publications for OSM Gene

  1. Oncostatin M induces dendritic cell maturation and Th1 polarization. (PMID: 20206608) Jung I.D. … Park Y.M. (Biochem. Biophys. Res. Commun. 2010) 23 67
  2. The inflammatory mediator oncostatin M induces angiopoietin 2 expression in endothelial cells in vitro and in vivo. (PMID: 20088942) Rychli K. … Wojta J. (J. Thromb. Haemost. 2010) 23 67
  3. IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia. (PMID: 20468050) Baker B.J. … Benveniste E.N. (Glia 2010) 23 67
  4. Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. (PMID: 20484035) Yamashita T. … Kaneko S. (Cancer Res. 2010) 23 67
  5. Gingival crevicular fluid levels of oncostatin M in periodontal conditions. (PMID: 20189410) Thorat Manojkumar S. … Raju A. (Cytokine 2010) 23 67

Products for OSM Gene

Sources for OSM Gene

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