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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSM Gene

protein-coding   GIFtS: 66
GCID: GC22M030658

Oncostatin M

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oncostatin M1 2
oncostatin-M2

External Ids:    HGNC: 85061   Entrez Gene: 50082   Ensembl: ENSG000000999857   OMIM: 1650955   UniProtKB: P137253   

Export aliases for OSM gene to outside databases

Previous GC identifers: GC22M027354 GC22M028983 GC22M013620


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSM Gene:
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte
colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the
proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF
from endothelial cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for OSM Gene: 
OSM (oncostatin M) is a protein-coding gene. Diseases associated with OSM include cerebral meningioma, and osteochondrosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include oncostatin-M receptor binding and growth factor activity.

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725
Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation
of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses
both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers
composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development
and regeneration (By similarity)

Gene Wiki entry for OSM (Oncostatin M) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSM gene promoter:
         Max   STAT1   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSM promoter sequence
   Search SABiosciences Chromatin IP Primers for OSM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

OSM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSM gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030658:  view genomic region     (about GC identifiers)

Start:
30,658,818 bp from pter      End:
30,662,829 bp from pter
Size:
4,012 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725 (See protein sequence)
Recommended Name: Oncostatin-M precursor  
Size: 252 amino acids; 28484 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for OSM:
1EVS (3D)    
Secondary accessions: Q6FHP8 Q9UCP6

Explore the universe of human proteins at neXtProt for OSM: NX_P13725

Explore proteomics data for OSM at MOPED 

Post-translational modifications:

  • UniProtKB: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory
    activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13725

  • OSM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OSM Protein Expression
    REFSEQ proteins: NP_065391.1  
    ENSEMBL proteins: 
     ENSP00000215781   ENSP00000383893   ENSP00000384543  

    Human Recombinant Protein Products for OSM: 
    EMD Millipore Purified and/or Recombinant OSM Protein
    R&D Systems Recombinant & Natural Proteins for OSM (Oncostatin M/OSM)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for OSM
    OriGene Protein Over-expression Lysate for OSM
    OriGene MassSpec for OSM 
    OriGene Custom Protein Services for OSM
    GenScript Purified and Recombinant Proteins for OSM
    Novus Biologicals OSM Proteins
    Novus Biologicals OSM Lysates
    Sino Biological Recombinant Protein for OSM
    Sino Biological Cell Lysate for OSM 
    ProSpec Recombinant Protein for OSM
    Cloud-Clone Corp. Proteins for OSM 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005900oncostatin-M receptor complex IDA8999038

    OSM for ontologies           About GeneDecksing



    OSM Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Superior Antibodies for OSM
    Novus Biologicals OSM Antibodies
    Abcam antibodies for OSM
    Cloud-Clone Corp. Antibodies for OSM 
    ThermoFisher Antibodies for OSM
    LSBio Antibodies in human, mouse, rat for OSM 

    Assay Products for OSM: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSM
    R&D Systems ELISAs for OSM (Oncostatin M/OSM)
    GenScript Custom Assay Services for OSM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSM 
    Cloud-Clone Corp. CLIAs for OSM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR019827 Leukemia_IF/oncostatin_CS
     IPR001581 Leukemia_IF/oncostatin

    Graphical View of Domain Structure for InterPro Entry P13725

    ProtoNet protein and cluster: P13725

    1 Blocks protein domain: IPB003623 Oncostatin

    UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725
    Similarity: Belongs to the LIF/OSM family


    OSM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ONCM_HUMAN, P13725
    Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation
    of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses
    both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers
    composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development
    and regeneration (By similarity)

         Genatlas biochemistry entry for OSM:
    oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes

         Summary:
    During embryonic development, OSM as signaling molecule is secreted from the following cells: Hematopoietic Stem Cells in Liver Bud It affects the following cells: Fetal Hepatocytes in Liver Lobule

    OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature hepatocytes from Liver, Hepatocyte-like cells from Liver (see all).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA8999038
    GO:0005147oncostatin-M receptor binding IPI8999038
    GO:0008083growth factor activity IDA8999038
         
    OSM for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for OSM:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Osm):
     behavior/neurological  integument  nervous system 

    OSM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Osmtm1Ymo for OSM

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OSM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OSM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSM 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSM
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate OSM (see all 27):
    hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidOSM 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSM

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of OSM

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OSM (see all 7)
    OriGene ORF clones in mouse, rat for OSM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
    Sino Biological Human cDNA Clone for OSM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSM
    Sirion Biotech Customized lentivirus for stable overexpression of OSM 
                         Customized lentivirus expression plasmids for stable overexpression of OSM 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OSM
    Search LifeMap BioReagents cell lines for OSM
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OSM About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Rho Family GTPases
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for OSM
        Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Thrombopoetin signaling via JAK-STAT pathway

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for OSM (see all 17)
        MAPK Signaling
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases

    4 GeneGo (Thomson Reuters) Pathways for OSM
        Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Thrombopoetin signaling via JAK-STAT pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    2 BioSystems Pathways for OSM
        Adipogenesis
    Oncostatin M Signaling Pathway



    3         Kegg Pathways  (Kegg details for OSM):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway


    OSM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for OSM (P137252, 3 ENSP000002157814) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401892, 3, ENSP000003387994MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000338799
    TNNT1P138052, 3, ENSP000002919014MINT-8275017 I2D: score=2 STRING: ENSP00000291901
    LIFRP427022, 3, ENSP000002634094MINT-62478 MINT-62476 I2D: score=3 STRING: ENSP00000263409
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0006915apoptotic process IEA--
    GO:0006955immune response IEA--
    GO:0007275multicellular organismal development TAS1717982
    GO:0007422peripheral nervous system development IEA--

    OSM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OSM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSM (ONCM)

    10/56 Novoseek inferred chemical compound relationships for OSM gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 96.2 297 11602599 (4), 14499864 (4), 10692570 (4), 8833034 (4) (see all 99)
    tyrosine 59.2 60 1324279 (6), 8625884 (3), 7688764 (3), 1655740 (2) (see all 31)
    il 11 55.2 2 8605875 (1)
    b 723 50.4 8 8985750 (1), 8590544 (1)
    dexamethasone 46.1 52 7647014 (4), 18470681 (4), 9252193 (2), 7887453 (2) (see all 24)
    piceatannol 41.7 4 15022320 (2), 15665043 (2)
    vegf 35.9 81 15665043 (9), 14603252 (7), 17525365 (6), 14499864 (4) (see all 20)
    pd 98,059 34.3 10 10930307 (1), 15890357 (1), 19652200 (1), 10925301 (1) (see all 9)
    herbimycin a 33.8 6 10930307 (1), 1324279 (1), 9683456 (1), 9794437 (1) (see all 5)
    dichlorodiphenyltrichloroethane 32.7 6 1394190 (2)

    Search CenterWatch for drugs/clinical trials and news about OSM / ONCM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSM gene: 
    NM_020530.4  

    Unigene Cluster for OSM:

    Oncostatin M
    Hs.248156  [show with all ESTs]
    Unigene Representative Sequence: NM_020530
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215781(uc003ahb.3) ENST00000403389 ENST00000403463
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSM
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate OSM (see all 27):
    hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidOSM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSM
    Clone
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    OriGene clones in human, mouse for OSM (see all 7)
    OriGene ORF clones in mouse, rat for OSM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSM
    Sirion Biotech Customized lentivirus for stable overexpression of OSM 
                         Customized lentivirus expression plasmids for stable overexpression of OSM 
    Primer
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    OriGene qPCR primer pairs and template standards for OSM
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSM

    Additional mRNA sequence: 

    AB451493.1 BC011589.1 CR456534.1 CR541703.1 

    1 DOTS entry:

    DT.425916 

    24/34 AceView cDNA sequences (see all 34):

    CD366754 BM544068 AW339551 AA534303 AW467754 CD365429 BQ922996 NM_020530 
    BC011589 CD365526 CD365505 AW001330 CR456534 AI696470 AI476474 CD365006 
    AI079327 CD370284 CD368803 AI383244 BM562358 CR541703 BI907464 BX280034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSM expression in normal human tissues (normalized intensities)      OSM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAATTTAT
    OSM Expression
    About this image


    OSM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Liver Bud
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
             bone marrow   
     
     Oral Cavity (Gastrointestinal Tract)
             saliva   
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells

    See OSM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSM

    SOURCE GeneReport for Unigene cluster: Hs.248156
        SABiosciences Expression via Pathway-Focused PCR Arrays including OSM (see all 6): 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OSM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSM
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSM
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OSM gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osm1 , 5 oncostatin M1, 5 64.71(n)1
    52.49(a)1
      11 (2.94 cM)5
    184131  NM_001013365.21  NP_001013383.11 
     42364205 


    ENSEMBL Gene Tree for OSM (if available)
    TreeFam Gene Tree for OSM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/259 SNPs in OSM are shown (see all 259)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398351731,2
    Cuntested130660417(+) GTGCTC/G/TTCTCA 2 K E mis11NA 3062
    rs1445301531,2
    C--30658434(+) TTGGTA/GTATAA 1 -- ds50010--------
    rs1119600481,2
    C,F--30658487(+) CACACA/CCCCAT 1 -- ds50012Minor allele frequency- C:0.09NA 122
    rs1396908951,2
    --30658696(+) AAGGAC/TCTCCA 1 -- ds50010--------
    rs72890951,2
    C,F,A,H--30658722(+) ATGGAC/TGCTTT 1 -- ds500117Minor allele frequency- T:0.22NS EA NA WA 2338
    rs1174581091,2
    F--30658964(+) TCGCAG/CTTTCT 1 -- ut311Minor allele frequency- C:0.01EA 120
    rs1143645771,2
    C,F--30659057(+) CCCAAG/AACGGG 1 -- ut311Minor allele frequency- A:0.09WA 118
    rs1497827561,2
    C--30659072(+) CCGGCG/TCTGGG 1 -- ut310--------
    rs572480971,2
    C--30659122(+) CCAGCA/GCCATT 1 -- ut310--------
    rs1859945361,2
    --30659273(+) GACCTA/GCCCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OSM (30658818 - 30662829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OSM:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4954n71CNV Loss21882294
    nsv829171CNV Loss20364138
    dgv4955n71CNV Loss21882294
    nsv914970CNV Loss21882294
    nsv834174CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165095    OMIM disorders: --

    20/88 diseases for OSM (see all 88):    About MalaCards
    cerebral meningioma    osteochondrosis    breast carcinoma in situ    kaposi's sarcoma
    primary cutaneous amyloidosis    plasmacytoma    classic kaposi sarcoma    refractory anemia
    systemic mastocytosis    sialadenitis    arterial occlusive disease    neonatal jaundice
    breast cyst    arthropathy    keratoacanthoma    mastocytosis
    status epilepticus    cutaneous malignant melanoma    periodontal disease    bullous pemphigoid

    1 disease from the University of Copenhagen DISEASES database for OSM:
    Arthritis

    OSM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/72 Novoseek inferred disease relationships for OSM gene (see all 72)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 83.6 407 1380037 (5), 12684701 (4), 8187629 (3), 8144663 (2) (see all 99)
    stage melanoma 67.7 7 8011699 (1), 9627714 (1), 10843728 (1), 17374732 (1)
    response acute phase 66.5 16 19158344 (3), 15878349 (2), 7780030 (1), 12773095 (1) (see all 10)
    kaposi sarcoma 60 27 8030759 (2), 8728040 (2), 7907664 (2), 1333810 (1) (see all 16)
    necrosis 53.6 111 12730964 (2), 12505065 (2), 15883123 (2), 10693867 (2) (see all 74)
    myeloma 51.1 31 8816418 (4), 7647014 (2), 10350333 (2), 12148907 (2) (see all 11)
    inflammation 42.7 36 19467046 (2), 18981146 (2), 18641356 (2), 7999087 (1) (see all 24)
    melanoma 41.7 88 8504408 (4), 9664143 (4), 11407148 (4), 7780030 (3) (see all 28)
    rheumatoid arthritis 41.1 39 9135222 (2), 9182920 (2), 17009243 (2), 10693867 (2) (see all 19)
    tumors 40.7 174 18317962 (5), 10786810 (4), 11494026 (3), 12948403 (3) (see all 96)

    Genetic Association Database (GAD): OSM
    Human Genome Epidemiology (HuGE) Navigator: OSM (7 documents)
    Tumor Gene Database (TGDB): OSM

    Export disorders for OSM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSM gene, integrated from 9 sources (see all 641):
    (articles sorted by number of sources associating them with OSM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oncostatin M is a member of a cytokine family that includes leukemia- inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PubMed id 1717982)1, 2, 3, 9 Rose T.M. and Bruce A.G. (1991)
    2. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 9 Mosley B....Cosman D. (1996)
    3. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PubMed id 1542793)1, 2, 9 Miles S.A.... Linsley P.S. (1992)
    4. Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. (PubMed id 2026606)1, 2, 9 Kallestad J.C.... Linsley P.S. (1991)
    5. Cleavage of a hydrophilic C-terminal domain increases growth- inhibitory activity of oncostatin M. (PubMed id 2325640)1, 2, 9 Linsley P.S.... Neubauer M. (1990)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. (PubMed id 10997905)1, 2 Deller M.C....Heath J.K. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5008 HGNC: 8506 AceView: OSM Ensembl:ENSG00000099985 euGenes: HUgn5008
    ECgene: OSM Kegg: 5008 H-InvDB: OSM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OSM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSM gene:
    Search GeneIP for patents involving OSM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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