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Aliases for OSM Gene

Aliases for OSM Gene

  • Oncostatin M 2 3
  • Oncostatin-M 3

External Ids for OSM Gene

Previous GeneCards Identifiers for OSM Gene

  • GC22M027354
  • GC22M028983
  • GC22M030658
  • GC22M013620

Summaries for OSM Gene

Entrez Gene Summary for OSM Gene

  • Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSM Gene

OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include osteochondrosis and cerebral meningioma. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include cytokine activity and oncostatin-M receptor binding.

UniProtKB/Swiss-Prot for OSM Gene

  • Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Gene Wiki entry for OSM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSM Gene

Genomics for OSM Gene

Regulatory Elements for OSM Gene

Genomic Location for OSM Gene

Start:
30,262,828 bp from pter
End:
30,266,840 bp from pter
Size:
4,013 bases
Orientation:
Minus strand

Genomic View for OSM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSM Gene

Proteins for OSM Gene

  • Protein details for OSM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13725-ONCM_HUMAN
    Recommended name:
    Oncostatin-M
    Protein Accession:
    P13725
    Secondary Accessions:
    • Q6FHP8
    • Q9UCP6

    Protein attributes for OSM Gene

    Size:
    252 amino acids
    Molecular mass:
    28484 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OSM Gene

neXtProt entry for OSM Gene

Proteomics data for OSM Gene at MOPED

Post-translational modifications for OSM Gene

  • Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
  • Glycosylation at Asn100 and Asn217
  • Modification sites at PhosphoSitePlus

Other Protein References for OSM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for OSM (Oncostatin M/OSM)

Protein Products

No data available for DME Specific Peptides for OSM Gene

Domains for OSM Gene

Suggested Antigen Peptide Sequences for OSM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13725

UniProtKB/Swiss-Prot:

ONCM_HUMAN :
  • P13725
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with OSM: view

No data available for Gene Families for OSM Gene

Function for OSM Gene

Molecular function for OSM Gene

GENATLAS Biochemistry: oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes
UniProtKB/Swiss-Prot Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

LifeMap Function Summary for OSM Gene

During embryonic development, OSM as signaling molecule is secreted from the following cells
It affects the following cells:
OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 8999038
GO:0005147 oncostatin-M receptor binding IPI 8999038
GO:0008083 growth factor activity IDA 8999038
genes like me logo Genes that share ontologies with OSM: view
genes like me logo Genes that share phenotypes with OSM: view

Animal Models for OSM Gene

MGI Knock Outs for OSM:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OSM Gene

Localization for OSM Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSM Gene COMPARTMENTS Subcellular localization image for OSM gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OSM: view

Pathways for OSM Gene

genes like me logo Genes that share pathways with OSM: view

PCR Array Products

Gene Ontology (GO) - Biological Process for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0006955 immune response IEA --
GO:0007275 multicellular organismal development TAS 1717982
GO:0007422 peripheral nervous system development IEA --
GO:0008283 cell proliferation TAS 1542793
genes like me logo Genes that share ontologies with OSM: view

Compounds for OSM Gene

(56) Novoseek inferred chemical compound relationships for OSM Gene

Compound -log(P) Hits PubMed IDs
gp 130 96.2 146
tyrosine 59.2 46
il 11 55.2 1
b 723 50.4 2
dexamethasone 46.1 35
genes like me logo Genes that share compounds with OSM: view

Transcripts for OSM Gene

mRNA/cDNA for OSM Gene

Unigene Clusters for OSM Gene

Oncostatin M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSM Gene

No ASD Table

Relevant External Links for OSM Gene

GeneLoc Exon Structure for
OSM
ECgene alternative splicing isoforms for
OSM

Expression for OSM Gene

mRNA expression in normal human tissues for OSM Gene

mRNA differential expression in normal tissues according to GTEx for OSM Gene

This gene is overexpressed in Whole Blood (37.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OSM Gene

SOURCE GeneReport for Unigene cluster for OSM Gene Hs.248156

genes like me logo Genes that share expressions with OSM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OSM Gene

Orthologs for OSM Gene

This gene was present in the common ancestor of mammals.

Orthologs for OSM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSM 35
  • 99.6 (n)
  • 99.21 (a)
OSM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSM 35
  • 69.34 (n)
  • 55.66 (a)
OSM 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSM 35
  • 77.07 (n)
  • 66.24 (a)
OSM 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osm 35
  • 64.75 (n)
  • 51.2 (a)
Osm 16
Osm 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osm 35
  • 66.19 (n)
  • 50.95 (a)
Species with no ortholog for OSM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSM Gene

ENSEMBL:
Gene Tree for OSM (if available)
TreeFam:
Gene Tree for OSM (if available)

Paralogs for OSM Gene

No data available for Paralogs for OSM Gene

Variants for OSM Gene

Sequence variations from dbSNP and Humsavar for OSM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1476576 -- 30,264,528(+) CAAGT(A/C)AGCCT intron-variant
rs2070889 -- 30,263,577(-) CATGG(C/T)CGGGC utr-variant-3-prime
rs2070890 -- 30,263,547(-) CTCCC(C/T)GAGGC utr-variant-3-prime
rs5753056 -- 30,266,784(+) CTGTG(C/T)GAGCA reference, missense, upstream-variant-2KB
rs5763917 -- 30,264,824(+) CAGAG(C/G)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSM Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
dgv4954n71 CNV Loss 21882294
nsv914970 CNV Loss 21882294
nsv834174 CNV Gain+Loss 17160897
dgv4955n71 CNV Loss 21882294

Relevant External Links for OSM Gene

HapMap Linkage Disequilibrium report
OSM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSM Gene

Disorders for OSM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for OSM Gene including...

Search for OSM Gene in MalaCards »

(1) University of Copenhagen DISEASES for OSM Gene

(72) Novoseek inferred disease relationships for OSM Gene

Disease -log(P) Hits PubMed IDs
leukemia 83.6 143
stage melanoma 67.7 4
response acute phase 66.5 13
kaposi sarcoma 60 19
necrosis 53.6 81

Relevant External Links for OSM

Genetic Association Database (GAD)
OSM
Human Genome Epidemiology (HuGE) Navigator
OSM
Tumor Gene Database (TGDB):
OSM
genes like me logo Genes that share disorders with OSM: view

No data available for UniProtKB/Swiss-Prot for OSM Gene

Publications for OSM Gene

  1. Oncostatin M is a member of a cytokine family that includes leukemia- inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PMID: 1717982) Rose T.M. … Bruce A.G. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. (PMID: 2026606) Kallestad J.C. … Linsley P.S. (J. Biol. Chem. 1991) 3 4 23
  3. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PMID: 1542793) Miles S.A. … Linsley P.S. (Science 1992) 3 4 23
  4. Cleavage of a hydrophilic C-terminal domain increases growth- inhibitory activity of oncostatin M. (PMID: 2325640) Linsley P.S. … Neubauer M. (Mol. Cell. Biol. 1990) 3 4 23
  5. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B. … Cosman D. (J. Biol. Chem. 1996) 3 4 23

Products for OSM Gene

Sources for OSM Gene

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