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OSM Gene

protein-coding   GIFtS: 66
GCID: GC22M030658

Oncostatin M

  See OSM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oncostatin M1 2
oncostatin-M2

External Ids:    HGNC: 85061   Entrez Gene: 50082   Ensembl: ENSG000000999857   OMIM: 1650955   UniProtKB: P137253   

Export aliases for OSM gene to outside databases

Previous GC identifers: GC22M027354 GC22M028983 GC22M013620


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSM Gene:
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte
colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the
proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF
from endothelial cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for OSM Gene:
OSM (oncostatin M) is a protein-coding gene. Diseases associated with OSM include osteochondrosis, and cerebral meningioma. GO annotations related to this gene include oncostatin-M receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725
Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation
of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses
both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers
composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development
and regeneration (By similarity)

Gene Wiki entry for OSM (Oncostatin M) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSM gene promoter:
         Max   STAT1   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSM promoter sequence
   Search Chromatin IP Primers for OSM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

OSM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSM gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030658:  view genomic region     (about GC identifiers)

Start:
30,658,818 bp from pter      End:
30,662,829 bp from pter
Size:
4,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725 (See protein sequence)
Recommended Name: Oncostatin-M precursor  
Size: 252 amino acids; 28484 Da
1 PDB 3D structure from and Proteopedia for OSM:
1EVS (3D)    
Secondary accessions: Q6FHP8 Q9UCP6

Explore the universe of human proteins at neXtProt for OSM: NX_P13725

Explore proteomics data for OSM at MOPED

Post-translational modifications: 

  • Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory
    activity1
  • Glycosylation2 at Asn100, Asn217
  • Modification sites at PhosphoSitePlus

  • See OSM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065391.1  
    ENSEMBL proteins: 
     ENSP00000215781   ENSP00000383893   ENSP00000384543  

    OSM Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant OSM Protein
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    OriGene Purified Proteins for OSM
    OriGene Protein Over-expression Lysate for OSM
    OriGene MassSpec for OSM
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    GenScript Purified and Recombinant Proteins for OSM
    Novus Biologicals OSM Proteins
    Novus Biologicals OSM Lysates
    Sino Biological Recombinant Protein for OSM
    Sino Biological Cell Lysate for OSM
    ProSpec Recombinant Protein for OSM
    Cloud-Clone Corp. Proteins for OSM

     
    Search eBioscience for Proteins for OSM 

     
    antibodies-online proteins for OSM (62 products) 

     
    antibodies-online peptides for OSM

    OSM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OSM
    R&D Systems Antibodies for OSM (Oncostatin M/OSM)
    OriGene Antibodies for OSM
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    Novus Biologicals OSM Antibodies
    Abcam antibodies for OSM
    Cloud-Clone Corp. Antibodies for OSM
    ThermoFisher Antibodies for OSM
    antibodies-online antibodies for OSM (81 products) 

    OSM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for OSM (Oncostatin M/OSM)         (see all)
    GenScript Custom Assay Services for OSM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSM
    Cloud-Clone Corp. CLIAs for OSM
    Search eBioscience for ELISAs for OSM 
    antibodies-online kits for OSM (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR019827 Leukemia_IF/oncostatin_CS
     IPR001581 Leukemia_IF/oncostatin

    Graphical View of Domain Structure for InterPro Entry P13725

    ProtoNet protein and cluster: P13725

    1 Blocks protein domain: IPB003623 Oncostatin

    UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725
    Similarity: Belongs to the LIF/OSM family


    Find genes that share domains with OSM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ONCM_HUMAN, P13725
    Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation
    of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses
    both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers
    composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development
    and regeneration (By similarity)

         Genatlas biochemistry entry for OSM:
    oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes

         Summary: 
    During embryonic development, OSM as signaling molecule is secreted from the following cells:
                
    Liver: Hematopoietic Stem Cells (Liver Bud)

    It affects the following cells:
    Liver: Fetal Hepatocytes (Liver Lobule)

    OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                fully expand
    Liver: Immature hepatocytes, Hepatocyte-like cells      fully expand to see all 4 cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA8999038
    GO:0005147oncostatin-M receptor binding IPI8999038
    GO:0008083growth factor activity IDA8999038
         
    Find genes that share ontologies with OSM           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for OSM:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Osm):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with OSM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Osmtm1Ymo for OSM

       genOway: Develop your customized and physiologically relevant rodent model for OSM

    miRNA
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    Block miRNA regulation of human, mouse, rat OSM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSM (see all 27):
    hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidOSM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSM
    Predesigned siRNA for gene silencing in human, mouse, rat OSM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSM

    Clone
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    GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
    Sino Biological Human cDNA Clone for OSM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSM

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ONCM_HUMAN, P13725: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    nucleus2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005900oncostatin-M receptor complex IDA8999038

    Find genes that share ontologies with OSM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OSM About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with OSM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for OSM (see all 17)
        MAPK Signaling
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases

    4 GeneGo (Thomson Reuters) Pathways for OSM
        Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Thrombopoetin signaling via JAK-STAT pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    2 BioSystems Pathways for OSM
        Adipogenesis
    Oncostatin M Signaling Pathway



    3 Kegg Pathways  (Kegg details for OSM):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OSM (see all 6): 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OSM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for OSM (P137252, 3 ENSP000002157814) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401892, 3, ENSP000003387994MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000338799
    TNNT1P138052, 3, ENSP000002919014MINT-8275017 I2D: score=2 STRING: ENSP00000291901
    LIFRP427022, 3, ENSP000002634094MINT-62478 MINT-62476 I2D: score=3 STRING: ENSP00000263409
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0006915apoptotic process ----
    GO:0006955immune response IEA--
    GO:0007275multicellular organismal development TAS1717982
    GO:0007422peripheral nervous system development IEA--

    Find genes that share ontologies with OSM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSM (ONCM)

    Selected Novoseek inferred chemical compound relationships for OSM gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 96.2 297 11602599 (4), 14499864 (4), 10692570 (4), 8833034 (4) (see all 99)
    tyrosine 59.2 60 1324279 (6), 8625884 (3), 7688764 (3), 1655740 (2) (see all 31)
    il 11 55.2 2 8605875 (1)
    b 723 50.4 8 8985750 (1), 8590544 (1)
    dexamethasone 46.1 52 7647014 (4), 18470681 (4), 9252193 (2), 7887453 (2) (see all 24)
    piceatannol 41.7 4 15022320 (2), 15665043 (2)
    vegf 35.9 81 15665043 (9), 14603252 (7), 17525365 (6), 14499864 (4) (see all 20)
    pd 98,059 34.3 10 10930307 (1), 15890357 (1), 19652200 (1), 10925301 (1) (see all 9)
    herbimycin a 33.8 6 10930307 (1), 1324279 (1), 9683456 (1), 9794437 (1) (see all 5)
    dichlorodiphenyltrichloroethane 32.7 6 1394190 (2)



    Find genes that share compounds with OSM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSM gene: 
    NM_020530.4  

    Unigene Cluster for OSM:

    Oncostatin M
    Hs.248156  [show with all ESTs]
    Unigene Representative Sequence: NM_020530
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215781(uc003ahb.3) ENST00000403389 ENST00000403463
    miRNA
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    hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidOSM 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
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      QuantiTect SYBR Green Assays in human, mouse, rat OSM
      QuantiFast Probe-based Assays in human, mouse, rat OSM

    Additional mRNA sequence: 

    AB451493.1 BC011589.1 CR456534.1 CR541703.1 

    1 DOTS entry:

    DT.425916 

    Selected AceView cDNA sequences (see all 34):

    AI696470 AA534303 CD365505 AW467754 BM544068 CD365429 CD365006 CD366754 
    CR456534 AI476474 BQ922996 AW001330 AW339551 CD365526 NM_020530 BC011589 
    BM562358 BX280034 CD370284 AI079327 AI383244 BI907124 CD368803 BM907828 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAATTTAT
    OSM Expression
    About this image


    OSM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
    OSM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248156
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OSM (see all 6): 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat OSM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OSM gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osm1 , 5 oncostatin M1, 5 64.75(n)1
    51.2(a)1
      11 (2.94 cM)5
    184131  NM_001013365.21  NP_001013383.11 
     42364205 


    ENSEMBL Gene Tree for OSM (if available)
    TreeFam Gene Tree for OSM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSM (see all 259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398351731,2
    Cuntested130660417(+) GTGCTC/G/TTCTCA 2 K E mis11NA 3062
    rs1445301531,2
    C--30658434(+) TTGGTA/GTATAA 1 -- ds50010--------
    rs1119600481,2
    C,F--30658487(+) CACACA/CCCCAT 1 -- ds50012Minor allele frequency- C:0.09NA 122
    rs1396908951,2
    --30658696(+) AAGGAC/TCTCCA 1 -- ds50010--------
    rs72890951,2
    C,F,A,H--30658722(+) ATGGAC/TGCTTT 1 -- ds500117Minor allele frequency- T:0.22NS EA NA WA 2338
    rs1174581091,2
    F--30658964(+) TCGCAG/CTTTCT 1 -- ut311Minor allele frequency- C:0.01EA 120
    rs1143645771,2
    C,F--30659057(+) CCCAAG/AACGGG 1 -- ut311Minor allele frequency- A:0.09WA 118
    rs1497827561,2
    C--30659072(+) CCGGCG/TCTGGG 1 -- ut310--------
    rs572480971,2
    C--30659122(+) CCAGCA/GCCATT 1 -- ut310--------
    rs1859945361,2
    --30659273(+) GACCTA/GCCCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OSM (30658818 - 30662829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OSM:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4954n71CNV Loss21882294
    nsv829171CNV Loss20364138
    dgv4955n71CNV Loss21882294
    nsv914970CNV Loss21882294
    nsv834174CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSM
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 165095    OMIM disorders: --

    4 diseases for OSM:    
    About MalaCards
    osteochondrosis    cerebral meningioma    kaposi's sarcoma    sialadenitis

    1 disease from the University of Copenhagen DISEASES database for OSM:
    Arthritis

    Find genes that share disorders with OSM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for OSM gene (see all 72)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 83.6 407 1380037 (5), 12684701 (4), 8187629 (3), 8144663 (2) (see all 99)
    stage melanoma 67.7 7 8011699 (1), 9627714 (1), 10843728 (1), 17374732 (1)
    response acute phase 66.5 16 19158344 (3), 15878349 (2), 7780030 (1), 12773095 (1) (see all 10)
    kaposi sarcoma 60 27 8030759 (2), 8728040 (2), 7907664 (2), 1333810 (1) (see all 16)
    necrosis 53.6 111 12730964 (2), 12505065 (2), 15883123 (2), 10693867 (2) (see all 74)
    myeloma 51.1 31 8816418 (4), 7647014 (2), 10350333 (2), 12148907 (2) (see all 11)
    inflammation 42.7 36 19467046 (2), 18981146 (2), 18641356 (2), 7999087 (1) (see all 24)
    melanoma 41.7 88 8504408 (4), 9664143 (4), 11407148 (4), 7780030 (3) (see all 28)
    rheumatoid arthritis 41.1 39 9135222 (2), 9182920 (2), 17009243 (2), 10693867 (2) (see all 19)
    tumors 40.7 174 18317962 (5), 10786810 (4), 11494026 (3), 12948403 (3) (see all 96)

    Genetic Association Database (GAD): OSM
    Human Genome Epidemiology (HuGE) Navigator: OSM (7 documents)
    Tumor Gene Database (TGDB): OSM

    Export disorders for OSM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for OSM gene, integrated from 10 sources (see all 644):
    (articles sorted by number of sources associating them with OSM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oncostatin M is a member of a cytokine family that includes leukemia- inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PubMed id 1717982)1, 2, 3, 9 Rose T.M. and Bruce A.G. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 9 Mosley B....Cosman D. (J. Biol. Chem. 1996)
    3. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PubMed id 1542793)1, 2, 9 Miles S.A.... Linsley P.S. (Science 1992)
    4. Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. (PubMed id 2026606)1, 2, 9 Kallestad J.C.... Linsley P.S. (J. Biol. Chem. 1991)
    5. Cleavage of a hydrophilic C-terminal domain increases growth- inhibitory activity of oncostatin M. (PubMed id 2325640)1, 2, 9 Linsley P.S.... Neubauer M. (Mol. Cell. Biol. 1990)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. (PubMed id 10997905)1, 2 Deller M.C....Heath J.K. (Structure 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5008 HGNC: 8506 AceView: OSM Ensembl:ENSG00000099985 euGenes: HUgn5008
    ECgene: OSM Kegg: 5008 H-InvDB: OSM

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OSM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OSM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OSM gene:
    Search GeneIP for patents involving OSM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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