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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OSM Gene

protein-coding GIFtS: 65
GCID: GC22M030658

oncostatin M

Explore 94 diseases affiliated with
OSM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oncostatin M¹ ²
MGC20461¹
Oncostatin-M¹

External Ids:	HGNC: 8506¹	Entrez Gene: 5008²	Ensembl: ENSG00000099985⁷	OMIM: 165095⁵	UniProtKB: P13725³

Export aliases for OSM gene to outside databases

Previous GC identifers: GC22M027354 GC22M028983 GC22M013620

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSM:

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating

factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor

cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725

Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of

AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both

type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR

and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By

similarity)

Gene Wiki entry for OSM (Oncostatin M)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OSM gene promoter:
Max STAT1 AP-1 ATF-2 c-Jun c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OSM promoter sequence

Search SABiosciences Chromatin IP Primers for OSM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

OSM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSM gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M030658: view genomic region (about GC identifiers)

Start:	30,658,818 bp from pter	End:	30,662,840 bp from pter
Size:	4,023 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725 (See protein sequence)

Recommended Name: Oncostatin-M precursor

Size: 252 amino acids; 28484 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for OSM:

1EVS (3D)

Secondary accessions: Q6FHP8 Q9UCP6

Explore the universe of human proteins at neXtProt for OSM: NX_P13725

Post-translational modifications:

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13725

OSM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065391.1

ENSEMBL proteins:

ENSP00000215781 ENSP00000383893 ENSP00000384543

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant OSM Protein
	R&D Systems Recombinant & Natural Proteins for OSM (Oncostatin M/OSM)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): OSM OriGene Protein Over-expression Lysate: OSM OriGene Custom Protein Services for OSM
	GenScript Purified and Recombinant Proteins for OSM
	Novus Biologicals OSM Proteins Novus Biologicals OSM Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for OSM
	Uscn Proteins for OSM

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--
GO:0005900	oncostatin-M receptor complex	IDA	8999038

OSM for ontologies About GeneDecksing

OSM Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for OSM (Oncostatin M/OSM)
	OriGene Antibodies (see all 2): OSM OriGene Custom Antibody Services for OSM
	GenScript Superior Antibodies for OSM
	Novus Biologicals OSM Antibodies
	Abcam antibodies for OSM
	Uscn Antibodies for OSM
	ThermoFisher Antibodies for OSM

Assay Products for OSM:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for OSM (Oncostatin M/OSM)
	GenScript Custom Assay Services for OSM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OSM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OSM for domains About GeneDecksing

4 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR019827 Leukemia_IF/oncostatin_CS

IPR001581 Leukemia_IF/oncostatin

Graphical View of Domain Structure for InterPro Entry P13725

ProtoNet protein and cluster: P13725

1 Blocks protein family: IPB003623 Oncostatin

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725

Similarity: Belongs to the LIF/OSM family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ONCM_HUMAN, P13725

Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of

AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both

type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR

and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By

oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes

Summary:

During embryonic development, OSM as signaling molecule is secreted from the following cells: Hematopoietic Stem Cells in Liver Bud It affects the following cells: Fetal Hepatocytes in Liver Lobule

OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature hepatocyte-like cells, Immature hepatocyte-like cells (see all 4).

miRNA Products:		OriGene 3'-UTR Clone: OSM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSM
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate OSM (see all 27):
		hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*

		SwitchGear 3'UTR luciferase reporter plasmid: OSM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSM (see all 7) OriGene shRNA RFP: OSM OriGene siRNA: OSM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSM

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for OSM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSM (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSM OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
		Sino Biological Human cDNA Clone for OSM
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OSM
		Search LifeMap BioReagents cell lines for OSM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	8999038
GO:0005147	oncostatin-M receptor binding	IPI	8999038
GO:0008083	growth factor activity	IDA	8999038

OSM for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for OSM:

Decreased homologous recombina

Increased gamma-H2AX phosphory

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-out Osm^tm1Ymo for OSM
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Osm):

behavior/neurological

integument

nervous system

OSM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

	Immune response Oncostatin M signaling via MAPK in human cells	0.39			Oncostatin M Signaling Pathway	0.15
	Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Development Thrombopoetin signaling via JAK-STAT pathway

Development Thrombopoetin signaling via JAK-STAT pathway

1.00

Development_Thrombopoetin signaling via JAK-STAT pathway

1.00

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for OSM

	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Development Thrombopoetin signaling via JAK-STAT pathway

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for OSM (see all 17)

	MAPK Signaling
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Rho Family GTPases

4 GeneGo (Thomson Reuters) Pathways for OSM

	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Development Thrombopoetin signaling via JAK-STAT pathway
	Immune response Oncostatin M signaling via MAPK in human cells

2 BioSystems Pathways for OSM

	Oncostatin M Signaling Pathway
	Adipogenesis

2 Kegg Pathways (Kegg details for OSM):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

OSM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for OSM

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for OSM (P13725^{2, 3} ENSP00000215781⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL6ST	P40189²^,³, ENSP00000338799⁴	MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000338799
TNNT1	P13805²^,³, ENSP00000291901⁴	MINT-8275017 I2D: score=2 STRING: ENSP00000291901
LIFR	P42702²^,³, ENSP00000263409⁴	MINT-62478 MINT-62476 I2D: score=3 STRING: ENSP00000263409
COL4A4	P53420³, ENSP00000379866⁴	I2D: score=1 STRING: ENSP00000379866
COL4A6	Q14031³, ENSP00000361290⁴	I2D: score=1 STRING: ENSP00000361290

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002675	positive regulation of acute inflammatory response	IC	8999038
GO:0006915	apoptotic process	IEA	--
GO:0006955	immune response	IEA	--
GO:0007275	multicellular organismal development	TAS	1717982
GO:0007422	peripheral nervous system development	IEA	--

OSM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OSM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OSM
10/56 Novoseek chemical compound relationships for OSM gene (see all 56) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	96.2	297	11602599 (4), 14499864 (4), 10692570 (4), 8833034 (4) (see all 99)
tyrosine	59.2	60	1324279 (6), 8625884 (3), 7688764 (3), 1655740 (2) (see all 31)
il 11	55.2	2	8605875 (1)
b 723	50.4	8	8985750 (1), 8590544 (1)
dexamethasone	46.1	52	7647014 (4), 18470681 (4), 9252193 (2), 7887453 (2) (see all 24)
piceatannol	41.7	4	15022320 (2), 15665043 (2)
vegf	35.9	81	15665043 (9), 14603252 (7), 17525365 (6), 14499864 (4) (see all 20)
pd 98,059	34.3	10	10930307 (1), 15890357 (1), 19652200 (1), 10925301 (1) (see all 9)
herbimycin a	33.8	6	10930307 (1), 1324279 (1), 9683456 (1), 9794437 (1) (see all 5)
dichlorodiphenyltrichloroethane	32.7	6	1394190 (2)

Search CenterWatch for drugs/clinical trials and news about OSM / ONCM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OSM gene:

NM_020530.4

Unigene Cluster for OSM:

Oncostatin M

Hs.248156 [show with all ESTs]

Unigene Representative Sequence: NM_020530

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000215781(uc003ahb.3) ENST00000403389 ENST00000403463

miRNA Products:		OriGene 3'-UTR Clone: OSM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSM
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate OSM (see all 27):
		hsa-miR-16-2* hsa-miR-106a hsa-miR-765 hsa-miR-340 hsa-miR-519a hsa-miR-4325 hsa-miR-93 hsa-miR-15b*

		SwitchGear 3'UTR luciferase reporter plasmid: OSM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSM (see all 7) OriGene shRNA RFP: OSM OriGene siRNA: OSM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSM

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSM (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSM OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OSM (NM_020530)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSM

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSM

Additional cDNA sequence:

AB451493.1 BC011589.1 CR456534.1 CR541703.1

1 DOTS entry:

DT.425916

24/34 AceView cDNA sequences (see all 34):

AI696470 CD365429 AW339551 CD365006 BC011589 AA534303 NM_020530 AW467754

BM544068 AI476474 AW001330 CD366754 BQ922996 CD365526 CD365505 CR456534

CD368803 AI383244 BI907464 BI907124 BM907828 CD370284 AA931201 AI079327

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OSM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAATTTAT

About this image

OSM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Bud

Hematopoietic Stem Cells

Selective marker (cell-identifying gene)

Blood

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OSM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSM

SOURCE GeneReport for Unigene cluster: Hs.248156

SABiosciences Expression via Pathway-Focused PCR Arrays including OSM (see all 6):

Interferons & Receptors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Common Cytokines in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OSM gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Osm^{1 , 5}	oncostatin M^{1, 5}	64.71(n)¹ 52.49(a)¹		11 (2.94 cM)⁵ 18413¹ NM_001013365.2¹ NP_001013383.1¹ 4236420⁵

ENSEMBL Gene Tree for OSM (if available)
TreeFam Gene Tree for OSM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139835173^1,2	C	other	30660417(+)	`GTGCTC/G/TTCTCA`	3	K Q E	mis¹		1		NA	3062
rs144530153^1,2		--	30658434(+)	`TTGGTA/GTATAA`	1	--	ds500¹		0	--	--	--	--
rs111960048^1,2	C,	--	30658487(+)	`CACACA/CCCCAT`	1	--	ds500¹		2		NA	122
rs139690895^1,2		--	30658696(+)	`AAGGAC/TCTCCA`	1	--	ds500¹		0	--	--	--	--
rs7289095^1,2	C,F,A,H,	--	30658722(+)	`ATGGAC/TGCTTT`	1	--	ds500¹		17		NS EA NA WA	2338
rs117458109^1,2		--	30658964(+)	`TCGCAG/CTTTCT`	1	--	ut3¹		1		EA	120
rs114364577^1,2	C,F,	--	30659057(+)	`CCCAAG/AACGGG`	1	--	ut3¹		1		WA	118
rs149782756^1,2	C,	--	30659072(+)	`CCGGCG/TCTGGG`	1	--	ut3¹		0	--	--	--	--
rs57248097^1,2	C	--	30659122(+)	`CCAGCA/GCCATT`	1	--	ut3¹		0	--	--	--	--
rs185994536^1,2		--	30659273(+)	`GACCTA/GCCCCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OSM (30658818 - 30662840 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OSM: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSM

DNA2.0 Custom Variant and Variant Library Synthesis for OSM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OSM for disorders           About GeneDecksing

OMIM gene information: 165095    OMIM disorders: --

20/94 diseases for OSM (see all 94):    About MalaCards

arterial occlusive disease peripheral arterial occlusive disease leukemia kaposi's sarcoma

classic kaposi sarcoma abdominal aortic aneurysm status epilepticus primary cutaneous amyloidosis

aortic aneurysm bullous pemphigoid neonatal jaundice cutaneous malignant melanoma

plasmacytoma systemic mastocytosis mastocytosis cervical squamous cell carcinoma

systemic lupus erythematosus allergic rhinitis squamous cell carcinoma lupus erythematosus

2 diseases from the University of Copenhagen DISEASES database for OSM:

Kaposi's sarcoma Arthritis

10/72 Novoseek disease relationships for OSM gene (see all 72) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	83.6	407	1380037 (5), 12684701 (4), 8187629 (3), 8144663 (2) (see all 99)
stage melanoma	67.7	7	8011699 (1), 9627714 (1), 10843728 (1), 17374732 (1)
response acute phase	66.5	16	19158344 (3), 15878349 (2), 7780030 (1), 12773095 (1) (see all 10)
kaposi sarcoma	60	27	8030759 (2), 8728040 (2), 7907664 (2), 1333810 (1) (see all 16)
necrosis	53.6	111	12730964 (2), 12505065 (2), 15883123 (2), 10693867 (2) (see all 74)
myeloma	51.1	31	8816418 (4), 7647014 (2), 10350333 (2), 12148907 (2) (see all 11)
inflammation	42.7	36	19467046 (2), 18981146 (2), 18641356 (2), 7999087 (1) (see all 24)
melanoma	41.7	88	8504408 (4), 9664143 (4), 11407148 (4), 7780030 (3) (see all 28)
rheumatoid arthritis	41.1	39	9135222 (2), 9182920 (2), 17009243 (2), 10693867 (2) (see all 19)
tumors	40.7	174	18317962 (5), 10786810 (4), 11494026 (3), 12948403 (3) (see all 96)

Human Genome Epidemiology (HuGE) Navigator: OSM (7 documents)
Tumor Gene Database (TGDB): OSM

Export disorders for OSM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OSM gene, integrated from 9 sources (see all 637):
(articles sorted by number of sources associating them with OSM)

Utopia: connect your pdf to the dynamic
world of online information

Oncostatin M is a member of a cytokine family that includes leukemia- inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PubMed id 1717982)^{1, 2, 3, 9} Rose T.M. and Bruce A.G. (1991)
Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)^{1, 2, 9} Mosley B....Cosman D. (1996)
Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PubMed id 1542793)^{1, 2, 9} Miles S.A.... Linsley P.S. (1992)
Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. (PubMed id 2026606)^{1, 2, 9} Kallestad J.C.... Linsley P.S. (1991)
Cleavage of a hydrophilic C-terminal domain increases growth- inhibitory activity of oncostatin M. (PubMed id 2325640)^{1, 2, 9} Linsley P.S.... Neubauer M. (1990)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. (PubMed id 10997905)^{1, 2} Deller M.C....Heath J.K. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M. (PubMed id 2779549)^{1, 2} Malik N.... Rose T.M. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5008	HGNC: 8506	AceView: OSM	Ensembl:ENSG00000099985	euGenes: HUgn5008
ECgene: OSM	Kegg: 5008	H-InvDB: OSM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OSM	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for OSM	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for OSM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for OSM gene:
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GeneCards and IP:
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