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Aliases for OSGIN2 Gene

Aliases for OSGIN2 Gene

  • Oxidative Stress Induced Growth Inhibitor Family Member 2 2 3
  • C8orf1 3 4 6
  • HT41 3 4
  • Oxidative Stress-Induced Growth Inhibitor 2 3
  • Chromosome 8 Open Reading Frame 1 2

External Ids for OSGIN2 Gene

Previous Symbols for OSGIN2 Gene

  • C8orf1

Summaries for OSGIN2 Gene

GeneCards Summary for OSGIN2 Gene

OSGIN2 (Oxidative Stress Induced Growth Inhibitor Family Member 2) is a Protein Coding gene. An important paralog of this gene is OSGIN1.

UniProtKB/Swiss-Prot for OSGIN2 Gene

  • May be involved in meiosis or the maturation of germ cells

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN2 Gene

Genomics for OSGIN2 Gene

Genomic Location for OSGIN2 Gene

Start:
89,901,859 bp from pter
End:
89,927,888 bp from pter
Size:
26,030 bases
Orientation:
Plus strand

Genomic View for OSGIN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSGIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN2 Gene

Regulatory Elements for OSGIN2 Gene

Proteins for OSGIN2 Gene

  • Protein details for OSGIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y236-OSGI2_HUMAN
    Recommended name:
    Oxidative stress-induced growth inhibitor 2
    Protein Accession:
    Q9Y236
    Secondary Accessions:

    Protein attributes for OSGIN2 Gene

    Size:
    505 amino acids
    Molecular mass:
    56672 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31054.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSGIN2 Gene

Proteomics data for OSGIN2 Gene at MOPED

Post-translational modifications for OSGIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN2 Gene

No data available for DME Specific Peptides for OSGIN2 Gene

Domains for OSGIN2 Gene

Protein Domains for OSGIN2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

OSGI2_HUMAN
Family:
  • Belongs to the OKL38 family.:
    • Q9Y236
genes like me logo Genes that share domains with OSGIN2: view

No data available for Gene Families for OSGIN2 Gene

Function for OSGIN2 Gene

Molecular function for OSGIN2 Gene

UniProtKB/Swiss-Prot Function: May be involved in meiosis or the maturation of germ cells

Gene Ontology (GO) - Molecular Function for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with OSGIN2: view
genes like me logo Genes that share phenotypes with OSGIN2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OSGIN2 Gene

Localization for OSGIN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSGIN2 Gene COMPARTMENTS Subcellular localization image for OSGIN2 gene
Compartment Confidence
nucleus 2
peroxisome 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN2: view

Pathways for OSGIN2 Gene

SuperPathways for OSGIN2 Gene

No Data Available

Interacting Proteins for OSGIN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000396445%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000396445 Q9Y236-OSGI2_HUMAN for OSGIN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with OSGIN2: view

No data available for Pathways by source for OSGIN2 Gene

Transcripts for OSGIN2 Gene

mRNA/cDNA for OSGIN2 Gene

Unigene Clusters for OSGIN2 Gene

Oxidative stress induced growth inhibitor family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN2 Gene

No ASD Table

Relevant External Links for OSGIN2 Gene

GeneLoc Exon Structure for
OSGIN2
ECgene alternative splicing isoforms for
OSGIN2

Expression for OSGIN2 Gene

mRNA expression in normal human tissues for OSGIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for OSGIN2 Gene Hs.436445

mRNA Expression by UniProt/SwissProt for OSGIN2 Gene

Q9Y236-OSGI2_HUMAN
Tissue specificity: Ubiquitous. Expressed at higher levels in testis and ovary
genes like me logo Genes that share expressions with OSGIN2: view

Orthologs for OSGIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSGIN2 36
  • 99.39 (n)
  • 99.27 (a)
OSGIN2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSGIN2 36
  • 92.84 (n)
  • 92.17 (a)
OSGIN2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSGIN2 36
  • 92.94 (n)
  • 95.25 (a)
OSGIN2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osgin2 36
  • 89.74 (n)
  • 92.35 (a)
Osgin2 16
Osgin2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSGIN2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSGIN2 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osgin2 36
  • 89.13 (n)
  • 91.99 (a)
chicken
(Gallus gallus)
Aves OSGIN2 36
  • 76.79 (n)
  • 81.75 (a)
OSGIN2 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSGIN2 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin2 36
  • 67.66 (n)
  • 69.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
osgin2 36
  • 63.49 (n)
  • 62.3 (a)
osgin2 37
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F30B5.4 36
  • 46.35 (n)
  • 34.58 (a)
F30B5.4 37
  • 26 (a)
OneToMany
Species with no ortholog for OSGIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN2 Gene

ENSEMBL:
Gene Tree for OSGIN2 (if available)
TreeFam:
Gene Tree for OSGIN2 (if available)

Paralogs for OSGIN2 Gene

Paralogs for OSGIN2 Gene

Selected SIMAP similar genes for OSGIN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSGIN2: view

Variants for OSGIN2 Gene

Sequence variations from dbSNP and Humsavar for OSGIN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15147 -- 89,926,722(+) GTTCT(C/T)CATGG utr-variant-3-prime
rs177537 -- 89,900,708(+) TAGTA(A/G)GTGTA upstream-variant-2KB
rs177538 -- 89,902,526(+) GCGTC(C/G)CCGCC upstream-variant-2KB, intron-variant
rs177539 -- 89,902,696(+) CCCCG(A/C)GACCC intron-variant
rs177540 -- 89,903,159(+) TTCTA(C/T)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSGIN2 Gene

Variant ID Type Subtype PubMed ID
nsv6296 CNV Insertion 18451855

Relevant External Links for OSGIN2 Gene

HapMap Linkage Disequilibrium report
OSGIN2

Disorders for OSGIN2 Gene

No disorders were found for OSGIN2 Gene.

No data available for UniProtKB/Swiss-Prot for OSGIN2 Gene

Publications for OSGIN2 Gene

  1. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. (PMID: 9933573) Tauchi H. … Nakamura Y. (Genomics 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for OSGIN2 Gene

Sources for OSGIN2 Gene

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