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Aliases for OSGIN2 Gene

Aliases for OSGIN2 Gene

  • Oxidative Stress Induced Growth Inhibitor Family Member 2 2 3 5
  • C8orf1 3 4
  • HT41 3 4
  • Oxidative Stress-Induced Growth Inhibitor 2 3
  • Chromosome 8 Open Reading Frame 1 2

External Ids for OSGIN2 Gene

Previous HGNC Symbols for OSGIN2 Gene

  • C8orf1

Previous GeneCards Identifiers for OSGIN2 Gene

  • GC08P090984
  • GC08P086124

Summaries for OSGIN2 Gene

GeneCards Summary for OSGIN2 Gene

OSGIN2 (Oxidative Stress Induced Growth Inhibitor Family Member 2) is a Protein Coding gene. Diseases associated with OSGIN2 include Retinitis Pigmentosa 62. An important paralog of this gene is OSGIN1.

UniProtKB/Swiss-Prot for OSGIN2 Gene

  • May be involved in meiosis or the maturation of germ cells.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN2 Gene

Genomics for OSGIN2 Gene

Regulatory Elements for OSGIN2 Gene

Enhancers for OSGIN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G089974 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.2 +73.4 73378 2.3 HDGF PKNOX1 JUN EBF1 RELA EED ETV6 RELB IKZF2 MTA2 OSGIN2 NBN RIPK2 RNU6-925P DECR1 GC08M089899
GH08G089847 1.3 Ensembl ENCODE dbSUPER 12.3 -53.2 -53162 1.7 CTCF CBX3 SIN3A MAX CEBPG RAD21 RFX5 YY1 CTBP1 GATA3 LOC101929709 NBN RNU6-925P OSGIN2 DECR1 ENSG00000275103 GC08M089901
GH08G089885 1.5 FANTOM5 Ensembl ENCODE 9.8 -13.8 -13778 4.6 TBP PKNOX1 FOXA2 SIN3A BRCA1 ZBTB40 YY1 ZNF366 SCRT2 RCOR1 RIPK2 OSGIN2 NBN LOC101929709 GC08M089901 RNU6-925P ENSG00000275103
GH08G089948 1.1 Ensembl ENCODE dbSUPER 11.7 +47.9 47904 2.6 ZNF316 JUND HLF ZBTB33 IRF1 ZNF507 NBN OSGIN2 RNU6-925P DECR1 GC08M089899
GH08G089959 1 dbSUPER 12.3 +60.3 60277 4.8 ATF1 FOXA2 PKNOX1 ARNT FEZF1 TCF12 GATA2 REST ZNF592 SMARCA4 NBN OSGIN2 RNU6-925P DECR1 GC08M089899
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSGIN2 on UCSC Golden Path with GeneCards custom track

Promoters for OSGIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226796 1041 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B CBX5 ZNF207 FOS

Genomic Location for OSGIN2 Gene

Chromosome:
8
Start:
89,901,859 bp from pter
End:
89,927,888 bp from pter
Size:
26,030 bases
Orientation:
Plus strand

Genomic View for OSGIN2 Gene

Genes around OSGIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSGIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSGIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN2 Gene

Proteins for OSGIN2 Gene

  • Protein details for OSGIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y236-OSGI2_HUMAN
    Recommended name:
    Oxidative stress-induced growth inhibitor 2
    Protein Accession:
    Q9Y236

    Protein attributes for OSGIN2 Gene

    Size:
    505 amino acids
    Molecular mass:
    56672 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31054.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSGIN2 Gene

Post-translational modifications for OSGIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN2 Gene

No data available for DME Specific Peptides for OSGIN2 Gene

Domains & Families for OSGIN2 Gene

Protein Domains for OSGIN2 Gene

Suggested Antigen Peptide Sequences for OSGIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y236

UniProtKB/Swiss-Prot:

OSGI2_HUMAN :
  • Belongs to the OKL38 family.
Family:
  • Belongs to the OKL38 family.
genes like me logo Genes that share domains with OSGIN2: view

No data available for Gene Families for OSGIN2 Gene

Function for OSGIN2 Gene

Molecular function for OSGIN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiosis or the maturation of germ cells.

Gene Ontology (GO) - Molecular Function for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008083 growth factor activity IBA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with OSGIN2: view
genes like me logo Genes that share phenotypes with OSGIN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OSGIN2

CRISPR Products

miRNA for OSGIN2 Gene

miRTarBase miRNAs that target OSGIN2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSGIN2 Gene

Localization for OSGIN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSGIN2 gene
Compartment Confidence
nucleus 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSGIN2 Gene

Pathways & Interactions for OSGIN2 Gene

SuperPathways for OSGIN2 Gene

No Data Available

Interacting Proteins for OSGIN2 Gene

Selected Interacting proteins: Q9Y236-OSGI2_HUMAN for OSGIN2 Gene via IID

Gene Ontology (GO) - Biological Process for OSGIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IBA --
GO:0051321 meiotic cell cycle IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OSGIN2: view

No data available for Pathways by source and SIGNOR curated interactions for OSGIN2 Gene

Drugs & Compounds for OSGIN2 Gene

No Compound Related Data Available

Transcripts for OSGIN2 Gene

Unigene Clusters for OSGIN2 Gene

Oxidative stress induced growth inhibitor family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN2 Gene

No ASD Table

Relevant External Links for OSGIN2 Gene

GeneLoc Exon Structure for
OSGIN2
ECgene alternative splicing isoforms for
OSGIN2

Expression for OSGIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSGIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of OSGIN2 Gene:

OSGIN2

SOURCE GeneReport for Unigene cluster for OSGIN2 Gene:

Hs.436445

mRNA Expression by UniProt/SwissProt for OSGIN2 Gene:

Q9Y236-OSGI2_HUMAN
Tissue specificity: Ubiquitous. Expressed at higher levels in testis and ovary.
genes like me logo Genes that share expression patterns with OSGIN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSGIN2 Gene

Orthologs for OSGIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSGIN2 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia OSGIN2 34 35
  • 92.94 (n)
cow
(Bos Taurus)
Mammalia OSGIN2 34 35
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Osgin2 34 16 35
  • 89.74 (n)
rat
(Rattus norvegicus)
Mammalia Osgin2 34
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia OSGIN2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSGIN2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSGIN2 34 35
  • 76.79 (n)
lizard
(Anolis carolinensis)
Reptilia OSGIN2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin2 34
  • 67.66 (n)
zebrafish
(Danio rerio)
Actinopterygii osgin2 34 35
  • 63.49 (n)
-- 34
worm
(Caenorhabditis elegans)
Secernentea CELE_F30B5.4 34
  • 46.35 (n)
F30B5.4 35
  • 26 (a)
OneToMany
Species where no ortholog for OSGIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN2 Gene

ENSEMBL:
Gene Tree for OSGIN2 (if available)
TreeFam:
Gene Tree for OSGIN2 (if available)

Paralogs for OSGIN2 Gene

Paralogs for OSGIN2 Gene

(1) SIMAP similar genes for OSGIN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSGIN2: view

Variants for OSGIN2 Gene

Sequence variations from dbSNP and Humsavar for OSGIN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000204755 -- 89,926,216(+) ATTTT(C/T)ATCGT utr-variant-3-prime
rs1000243361 -- 89,926,890(+) TATTA(A/G)GACCA utr-variant-3-prime
rs1000546438 -- 89,927,571(+) GTTAT(A/G)GCATG utr-variant-3-prime
rs1000585839 -- 89,908,308(+) GAGGC(C/T)ATGTA intron-variant
rs1000831051 -- 89,902,433(+) TCGCC(C/G)GGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OSGIN2 Gene

Variant ID Type Subtype PubMed ID
nsv6296 CNV insertion 18451855

Variation tolerance for OSGIN2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSGIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSGIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSGIN2 Gene

Disorders for OSGIN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSGIN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 62
  • rp62
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OSGIN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSGIN2
genes like me logo Genes that share disorders with OSGIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSGIN2 Gene

Publications for OSGIN2 Gene

  1. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. (PMID: 9933573) Tauchi H. … Nakamura Y. (Genomics 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64

Products for OSGIN2 Gene

Sources for OSGIN2 Gene

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