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Aliases for OSGIN2 Gene

Aliases for OSGIN2 Gene

  • Oxidative Stress Induced Growth Inhibitor Family Member 2 2 3 5
  • C8orf1 3 4
  • HT41 3 4
  • Chromosome 8 Open Reading Frame 1 2

External Ids for OSGIN2 Gene

Previous HGNC Symbols for OSGIN2 Gene

  • C8orf1

Previous GeneCards Identifiers for OSGIN2 Gene

  • GC08P090984
  • GC08P086124

Summaries for OSGIN2 Gene

GeneCards Summary for OSGIN2 Gene

OSGIN2 (Oxidative Stress Induced Growth Inhibitor Family Member 2) is a Protein Coding gene. An important paralog of this gene is OSGIN1.

UniProtKB/Swiss-Prot for OSGIN2 Gene

  • May be involved in meiosis or the maturation of germ cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN2 Gene

Genomics for OSGIN2 Gene

Regulatory Elements for OSGIN2 Gene

Enhancers for OSGIN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSGIN2 on UCSC Golden Path with GeneCards custom track

Promoters for OSGIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSGIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSGIN2 Gene

89,901,859 bp from pter
89,927,888 bp from pter
26,030 bases
Plus strand

Genomic View for OSGIN2 Gene

Genes around OSGIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSGIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSGIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN2 Gene

Proteins for OSGIN2 Gene

  • Protein details for OSGIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxidative stress-induced growth inhibitor 2
    Protein Accession:

    Protein attributes for OSGIN2 Gene

    505 amino acids
    Molecular mass:
    56672 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31054.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN2 Gene


neXtProt entry for OSGIN2 Gene

Proteomics data for OSGIN2 Gene at MOPED

Post-translational modifications for OSGIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN2 Gene

No data available for DME Specific Peptides for OSGIN2 Gene

Domains & Families for OSGIN2 Gene

Protein Domains for OSGIN2 Gene

Suggested Antigen Peptide Sequences for OSGIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OKL38 family.
  • Belongs to the OKL38 family.
genes like me logo Genes that share domains with OSGIN2: view

No data available for Gene Families for OSGIN2 Gene

Function for OSGIN2 Gene

Molecular function for OSGIN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiosis or the maturation of germ cells.

Phenotypes for OSGIN2 Gene

genes like me logo Genes that share phenotypes with OSGIN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OSGIN2

miRNA for OSGIN2 Gene

miRTarBase miRNAs that target OSGIN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSGIN2 Gene

Localization for OSGIN2 Gene

Subcellular locations from

Jensen Localization Image for OSGIN2 Gene COMPARTMENTS Subcellular localization image for OSGIN2 gene
Compartment Confidence
nucleus 3
peroxisome 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OSGIN2 Gene

Pathways & Interactions for OSGIN2 Gene

SuperPathways for OSGIN2 Gene

No Data Available

Interacting Proteins for OSGIN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000396445 Q9Y236-OSGI2_HUMAN for OSGIN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OSGIN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for OSGIN2 Gene

Drugs & Compounds for OSGIN2 Gene

No Compound Related Data Available

Transcripts for OSGIN2 Gene

Unigene Clusters for OSGIN2 Gene

Oxidative stress induced growth inhibitor family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN2 Gene

No ASD Table

Relevant External Links for OSGIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSGIN2 Gene

mRNA expression in normal human tissues for OSGIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for OSGIN2 Gene Hs.436445

mRNA Expression by UniProt/SwissProt for OSGIN2 Gene

Tissue specificity: Ubiquitous. Expressed at higher levels in testis and ovary.
genes like me logo Genes that share expression patterns with OSGIN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OSGIN2 Gene

Orthologs for OSGIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSGIN2 35
  • 92.84 (n)
  • 92.17 (a)
  • 92 (a)
(Canis familiaris)
Mammalia OSGIN2 35
  • 92.94 (n)
  • 95.25 (a)
  • 95 (a)
(Mus musculus)
Mammalia Osgin2 35
  • 89.74 (n)
  • 92.35 (a)
Osgin2 16
Osgin2 36
  • 92 (a)
(Pan troglodytes)
Mammalia OSGIN2 35
  • 99.39 (n)
  • 99.27 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Osgin2 35
  • 89.13 (n)
  • 91.99 (a)
(Monodelphis domestica)
Mammalia OSGIN2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia OSGIN2 36
  • 65 (a)
(Gallus gallus)
Aves OSGIN2 35
  • 76.79 (n)
  • 81.75 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia OSGIN2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin2 35
  • 67.66 (n)
  • 69.92 (a)
(Danio rerio)
Actinopterygii -- 35
osgin2 35
  • 63.49 (n)
  • 62.3 (a)
osgin2 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea CELE_F30B5.4 35
  • 46.35 (n)
  • 34.58 (a)
F30B5.4 36
  • 26 (a)
Species with no ortholog for OSGIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN2 Gene

Gene Tree for OSGIN2 (if available)
Gene Tree for OSGIN2 (if available)

Paralogs for OSGIN2 Gene

Paralogs for OSGIN2 Gene

(1) SIMAP similar genes for OSGIN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSGIN2: view

Variants for OSGIN2 Gene

Sequence variations from dbSNP and Humsavar for OSGIN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35542900 - 89,914,651(+) TTGGG(C/T)ATGAT upstream-variant-2KB, reference, missense
rs35599414 - 89,924,970(+) ACTGT(C/G)TGCTT reference, missense
rs2141408 -- 89,909,876(+) GAGTA(A/C)TTGGT intron-variant
rs2142141 -- 89,927,977(+) CTGGG(C/G)ACAGT downstream-variant-500B
rs2223009 -- 89,903,607(+) CAAGC(C/G)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSGIN2 Gene

Variant ID Type Subtype PubMed ID
nsv6296 CNV Insertion 18451855

Variation tolerance for OSGIN2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSGIN2 Gene

Disorders for OSGIN2 Gene

Relevant External Links for OSGIN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSGIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSGIN2 Gene

Publications for OSGIN2 Gene

  1. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. (PMID: 9933573) Tauchi H. … Nakamura Y. (Genomics 1999) 2 3 4 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OSGIN2 Gene

Sources for OSGIN2 Gene