OSGIN2 Gene
protein-coding GIFtS: 44
GCID: GC08P090984
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oxidative stress induced growth inhibitor family member...(Previous name: chromosome 8 open reading frame 1 ) (Previous symbol: C8orf1)
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Aliases for OSGIN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
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| Oxidative Stress Induced Growth Inhibitor Family Member 21 2 | | C8orf11 2 3 5 | | HT411 | | Chromosome 8 Open Reading Frame 11 | | Oxidative Stress-Induced Growth Inhibitor 22 |
Export aliases for OSGIN2 gene to outside databasesPrevious GC identifer: GC08P086124 |
Summaries for OSGIN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OSGI2_HUMAN, Q9Y236Function: May be involved in meiosis or the maturation of germ cells
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Genomic Views for OSGIN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OSGIN2 gene promoter: USF1 AML1a USF-1 USF2 USF-1:USF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for OSGIN2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSGIN2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21OSGIN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P090984: view genomic region
(about GC identifiers)
Start:
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90,914,087 bp from pter |
End:
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90,940,116 bp from pter |
Size:
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26,030 bases |
Orientation:
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plus strand |
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Proteins for OSGIN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: OSGI2_HUMAN, Q9Y236 (See
protein sequence)Recommended Name: Oxidative stress-induced growth inhibitor 2 Size: 505 amino acids; 56672 Da
Sequence caution: Sequence=AAH31054.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Alternative splicing: 2 isoforms: Q9Y236-1 Q9Y236-2 (Ref.3 (AAH31054) sequence has a frameshift in position 3)Explore the universe of human proteins at neXtProt for OSGIN2: NX_Q9Y236
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y236 OSGIN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001119583.1 NP_004328.1 ENSEMBL proteins: ENSP00000297438 ENSP00000396445 ENSP00000431029 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
OSGIN2 for ontologies About GeneDecksing
OSGIN2 Antibody Products: Assay Products for OSGIN2: |
Protein
Domains / Families for OSGIN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y236 UniProtKB/Swiss-Prot: OSGI2_HUMAN, Q9Y236Similarity: Belongs to the OKL38 family |
Function for OSGIN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: OSGI2_HUMAN, Q9Y236Function: May be involved in meiosis or the maturation of germ cells
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): OSGIN2 (NM_001126111) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSGIN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGIN2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGIN2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
OSGIN2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for OSGIN2: Animal Models: 1 MGI phenotypic allele for Osgin2 (no phenotypes)
OSGIN2 for phenotypes About GeneDecksing
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Pathways & Interactions for OSGIN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSGIN2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 3 Interacting proteins for OSGIN2 (Q9Y2363 ENSP000003964454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0007126 | meiosis |
NAS | -- | | GO:0007281 | germ cell development |
NAS | -- |
OSGIN2 for ontologies About GeneDecksing
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Drugs & Compounds for OSGIN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OSGIN2 Search CenterWatch for drugs/clinical trials and news about OSGIN2 / OSGI2 
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Transcripts for OSGIN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OSGIN2 gene (2 alternative transcripts): NM_001126111.1 NM_004337.2 Unigene Cluster for OSGIN2: Oxidative stress induced growth inhibitor family member 2 Hs.436445 [show with all ESTs]Unigene Representative Sequence: NM_0011261113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297438(uc003yeg.3) ENST00000451899(uc003yeh.3) ENST00000520659
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): OSGIN2 (NM_001126111) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSGIN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGIN2  |
Additional cDNA sequence: AF061326.1 BC031054.1 5 DOTS entries: DT.444356 DT.92429221 DT.86836431 DT.40112330 DT.95268687 24/116 AceView cDNA sequences (see all 116): BU740525 NM_004337 BM722844 AA622749 BU735109 CA436292 BQ220931 C01106 AL705372 AA789031 AI078670 AI076467 CB120481 AI572275 BF002136 BQ575056 AI687791 BM788710 BM696488 BX117972 AF061326 BM790949 AI688382 AA293108 GeneLoc Exon Structure
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Expression for OSGIN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OSGIN2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATGTGAGCAT
About this image See OSGIN2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OSGIN2
SOURCE GeneReport for Unigene cluster: Hs.436445 UniProtKB/Swiss-Prot: OSGI2_HUMAN, Q9Y236Tissue specificity: Ubiquitous. Expressed at higher levels in testis and ovary SABiosciences Custom PCR Arrays for OSGIN2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSGIN2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSGIN2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSGIN2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGIN2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGIN2 |
Orthologs for OSGIN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OSGIN2 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for OSGIN2 (if available) TreeFam Gene Tree for OSGIN2 (if available)  |
Paralogs for OSGIN2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OSGIN2 gene
- OSGIN12
1 SIMAP similar gene for OSGIN2 using alignment to 2 protein entries: OSGI2_HUMAN (see all proteins):OSGIN1
OSGIN2 for paralogs About GeneDecksing
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Genomic Variants for OSGIN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for OSGIN2 (90914087 - 90940116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for OSGIN2: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSGIN2 |
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Disorders
/ Diseases for OSGIN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSGIN2 for disorders About GeneDecksing
OMIM gene information: 604598
OMIM disorders: --
1 disease for OSGIN2: About MalaCardsnijmegen breakage syndrome Export disorders for OSGIN2 gene to outside databases
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Publications for OSGIN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OSGIN2 gene integrated from 9 sources: (articles sorted by number of sources associating them with OSGIN2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. (PubMed id 9933573)1, 2, 3 Tauchi H.... Nakamura Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for OSGIN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing OSGIN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing OSGIN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSGIN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OSGIN2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for OSGIN2 gene: Search GeneIP for patents involving OSGIN2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for OSGIN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for OSGIN2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSGIN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSGIN2 | | OriGene Protein Over-expression Lysate for OSGIN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for OSGIN2 | | OriGene 3'-UTR Clone for OSGIN2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSGIN2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for OSGIN2 | | OriGene Custom Protein Services for OSGIN2 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSGIN2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSGIN2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSGIN2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSGIN2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGIN2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSGIN2 |
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| | | Search Tocris compounds for OSGIN2 |
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 | | OSGIN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGIN2 |
|  |  |  | | | ThermoFisher Antibodies for OSGIN2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGIN2 |
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