Aliases for OSGIN1 Gene
External Ids for OSGIN1 Gene
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
GeneCards Summary for OSGIN1 Gene
OSGIN1 (Oxidative Stress Induced Growth Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OSGIN2.
UniProtKB/Swiss-Prot for OSGIN1 Gene
Regulates the differentiation and proliferation of normal cells through the regulation of cell death.