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Aliases for OSGIN1 Gene

Aliases for OSGIN1 Gene

  • Oxidative Stress Induced Growth Inhibitor 1 2 3 5
  • Bone Marrow Stromal Cell-Derived Growth Inhibitor 2 3
  • Pregnancy-Induced Growth Inhibitor OKL38 3 4
  • Ovary, Kidney And Liver Protein 38 3 4
  • OKL38 3 4
  • Oxidative Stress-Induced Growth Inhibitor 1 3
  • Pregnancy Induced Growth Inhibitor 2
  • EC 61
  • EC 61
  • EC 1.6.5 61
  • HuOKL38 4
  • BDGI 3

External Ids for OSGIN1 Gene

Previous GeneCards Identifiers for OSGIN1 Gene

  • GC16P082541
  • GC16P069733

Summaries for OSGIN1 Gene

Entrez Gene Summary for OSGIN1 Gene

  • This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

GeneCards Summary for OSGIN1 Gene

OSGIN1 (Oxidative Stress Induced Growth Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and growth factor activity. An important paralog of this gene is OSGIN2.

UniProtKB/Swiss-Prot for OSGIN1 Gene

  • Regulates the differentiation and proliferation of normal cells through the regulation of cell death.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN1 Gene

Genomics for OSGIN1 Gene

Regulatory Elements for OSGIN1 Gene

Enhancers for OSGIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F083926 1.6 FANTOM5 Ensembl ENCODE 13 -20.7 -20712 2.6 PKNOX1 ARID4B SIN3A ZNF48 ZNF2 SLC30A9 ZNF143 FOS DEK SP5 OSGIN1 MLYCD TAF1C DNAAF1 HSDL1 LOC105371372 PIR36240
GH16F083825 1.4 FANTOM5 Ensembl ENCODE 10.9 -121.9 -121897 0.8 CBX3 WRNIP1 ZFP64 ZNF48 RAD21 ZNF143 DEK ZNF654 CEBPB USF2 MLYCD OSGIN1 HSDL1 LOC105371370
GH16F083992 1.2 Ensembl ENCODE 11.6 +45.7 45667 2.3 PKNOX1 ZFP64 ARID4B ZNF48 GATA2 FOS SMARCB1 MEF2D ATF4 PBX2 NECAB2 KLHL36 RNA5SP432 SLC38A8 OSGIN1 MLYCD ENSG00000261243 TAF1C ADAD2 ENSG00000260859
GH16F084592 1.8 FANTOM5 Ensembl ENCODE 5.8 +654.0 654046 19.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ENSG00000261243 KLHL36 COTL1 ZDHHC7 USP10 ENSG00000260859 HSDL1 KIAA0513 ENSG00000261471 OSGIN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSGIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSGIN1 Gene

83,948,282 bp from pter
83,966,332 bp from pter
18,051 bases
Plus strand

Genomic View for OSGIN1 Gene

Genes around OSGIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSGIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSGIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN1 Gene

Proteins for OSGIN1 Gene

  • Protein details for OSGIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxidative stress-induced growth inhibitor 1
    Protein Accession:
    Secondary Accessions:
    • Q52M33
    • Q86UQ1
    • Q96S88
    • Q9BZ70

    Protein attributes for OSGIN1 Gene

    560 amino acids
    Molecular mass:
    60849 Da
    Quaternary structure:
    No Data Available
    • Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.
    • Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Evidence={ECO:0000305}; Sequence=AAK01722.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN1 Gene


neXtProt entry for OSGIN1 Gene

Selected DME Specific Peptides for OSGIN1 Gene


Post-translational modifications for OSGIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN1 Gene

Domains & Families for OSGIN1 Gene

Protein Domains for OSGIN1 Gene

Suggested Antigen Peptide Sequences for OSGIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OKL38 family.
  • Belongs to the OKL38 family.
genes like me logo Genes that share domains with OSGIN1: view

No data available for Gene Families for OSGIN1 Gene

Function for OSGIN1 Gene

Molecular function for OSGIN1 Gene

UniProtKB/Swiss-Prot Function:
Regulates the differentiation and proliferation of normal cells through the regulation of cell death.
UniProtKB/Swiss-Prot Induction:
By pregnancy.

Enzyme Numbers (IUBMB) for OSGIN1 Gene

Gene Ontology (GO) - Molecular Function for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 11459809
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with OSGIN1: view
genes like me logo Genes that share phenotypes with OSGIN1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSGIN1 Gene

Localization for OSGIN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSGIN1 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSGIN1 Gene

Pathways & Interactions for OSGIN1 Gene

SuperPathways for OSGIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IEA,IDA 11459809
GO:0040008 regulation of growth IEA --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Pathways by source and SIGNOR curated interactions for OSGIN1 Gene

Transcripts for OSGIN1 Gene

Unigene Clusters for OSGIN1 Gene

Oxidative stress induced growth inhibitor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - -

Relevant External Links for OSGIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSGIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSGIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSGIN1 Gene

This gene is overexpressed in Liver (x14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSGIN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OSGIN1 Gene:


SOURCE GeneReport for Unigene cluster for OSGIN1 Gene:


mRNA Expression by UniProt/SwissProt for OSGIN1 Gene:

Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.
genes like me logo Genes that share expression patterns with OSGIN1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for OSGIN1 Gene

Orthologs for OSGIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSGIN1 34 35
  • 99.09 (n)
(Bos Taurus)
Mammalia OSGIN1 34 35
  • 87.14 (n)
(Canis familiaris)
Mammalia OSGIN1 34 35
  • 87 (n)
(Mus musculus)
Mammalia Osgin1 34 16 35
  • 82.32 (n)
(Rattus norvegicus)
Mammalia Osgin1 34
  • 82.32 (n)
(Monodelphis domestica)
Mammalia OSGIN1 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia OSGIN1 35
  • 68 (a)
(Gallus gallus)
Aves OSGIN1 34 35
  • 61.36 (n)
(Anolis carolinensis)
Reptilia OSGIN1 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin1 34
  • 59.26 (n)
(Danio rerio)
Actinopterygii osgn1 34 35
  • 59.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011390 34
  • 55.56 (n)
(Caenorhabditis elegans)
Secernentea F30B5.4 35
  • 25 (a)
Species where no ortholog for OSGIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN1 Gene

Gene Tree for OSGIN1 (if available)
Gene Tree for OSGIN1 (if available)

Paralogs for OSGIN1 Gene

Paralogs for OSGIN1 Gene

(1) SIMAP similar genes for OSGIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSGIN1: view

Variants for OSGIN1 Gene

Sequence variations from dbSNP and Humsavar for OSGIN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153054 -- 83,961,508(+) CTCAG(C/T)AGTTC intron-variant
rs10153189 -- 83,962,291(+) tggag(C/T)gcagt intron-variant
rs111238795 -- 83,962,178(+) AGAGA(A/C)AAGGT intron-variant
rs111351826 -- 83,961,138(+) TCTGA(A/G)ACAGG intron-variant
rs111436159 -- 83,965,113(+) TACAG(A/G)GACTA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OSGIN1 Gene

Variant ID Type Subtype PubMed ID
nsv573409 CNV loss 21841781
nsv528396 CNV loss 19592680
nsv517566 CNV gain+loss 19592680
nsv471106 CNV gain 18288195
nsv1065790 CNV loss 25217958
esv3639403 CNV loss 21293372
dgv5259n54 CNV loss 21841781
dgv3056n100 CNV loss 25217958

Variation tolerance for OSGIN1 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSGIN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSGIN1 Gene

Disorders for OSGIN1 Gene

Relevant External Links for OSGIN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSGIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSGIN1 Gene

Publications for OSGIN1 Gene

  1. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PMID: 14570898) Ong C.K. … Huynh H.T. (J. Biol. Chem. 2004) 2 3 4 64
  2. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PMID: 11459809) Huynh H.T. … Chan T.W.M. (Endocrinology 2001) 2 3 4 64
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  5. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. (PMID: 17192422) Li R. … Berliner J.A. (J. Lipid Res. 2007) 3 22 64

Products for OSGIN1 Gene

Sources for OSGIN1 Gene

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