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Aliases for OSGIN1 Gene

Aliases for OSGIN1 Gene

  • Oxidative Stress Induced Growth Inhibitor 1 2 3
  • OKL38 3 4 6
  • Bone Marrow Stromal Cell-Derived Growth Inhibitor 2 3
  • Pregnancy-Induced Growth Inhibitor OKL38 3 4
  • Ovary, Kidney And Liver Protein 38 3 4
  • Oxidative Stress-Induced Growth Inhibitor 1 3
  • Pregnancy Induced Growth Inhibitor 2
  • EC 2.7.1.130 64
  • EC 2.4.2.7 64
  • EC 1.6.5 64
  • HuOKL38 4
  • BDGI 3

External Ids for OSGIN1 Gene

Summaries for OSGIN1 Gene

Entrez Gene Summary for OSGIN1 Gene

  • This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

GeneCards Summary for OSGIN1 Gene

OSGIN1 (Oxidative Stress Induced Growth Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OSGIN2.

UniProtKB/Swiss-Prot for OSGIN1 Gene

  • Regulates the differentiation and proliferation of normal cells through the regulation of cell death.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN1 Gene

Genomics for OSGIN1 Gene

Genomic Location for OSGIN1 Gene

Start:
83,948,282 bp from pter
End:
83,966,332 bp from pter
Size:
18,051 bases
Orientation:
Plus strand

Genomic View for OSGIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSGIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN1 Gene

Regulatory Elements for OSGIN1 Gene

Proteins for OSGIN1 Gene

  • Protein details for OSGIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX0-OSGI1_HUMAN
    Recommended name:
    Oxidative stress-induced growth inhibitor 1
    Protein Accession:
    Q9UJX0
    Secondary Accessions:
    • Q52M33
    • Q86UQ1
    • Q96S88
    • Q9BZ70

    Protein attributes for OSGIN1 Gene

    Size:
    560 amino acids
    Molecular mass:
    60849 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors
    SequenceCaution:
    • Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Evidence={ECO:0000305}; Sequence=AAK01722.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSGIN1 Gene

Proteomics data for OSGIN1 Gene at MOPED

Selected DME Specific Peptides for OSGIN1 Gene

Post-translational modifications for OSGIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN1 Gene

Domains for OSGIN1 Gene

Protein Domains for OSGIN1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

OSGI1_HUMAN
Family:
  • Belongs to the OKL38 family.:
    • Q9UJX0
genes like me logo Genes that share domains with OSGIN1: view

No data available for Gene Families for OSGIN1 Gene

Function for OSGIN1 Gene

Molecular function for OSGIN1 Gene

UniProtKB/Swiss-Prot Function: Regulates the differentiation and proliferation of normal cells through the regulation of cell death.
UniProtKB/Swiss-Prot Induction: By pregnancy

Enzyme Numbers (IUBMB) for OSGIN1 Gene

Gene Ontology (GO) - Molecular Function for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 11459809
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with OSGIN1: view

Phenotypes for OSGIN1 Gene

GenomeRNAi human phenotypes for OSGIN1:
genes like me logo Genes that share phenotypes with OSGIN1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OSGIN1 Gene

Localization for OSGIN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSGIN1 Gene COMPARTMENTS Subcellular localization image for OSGIN1 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN1: view

Pathways for OSGIN1 Gene

SuperPathways for OSGIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 11459809
GO:0043065 positive regulation of apoptotic process IEA --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Pathways by source for OSGIN1 Gene

Transcripts for OSGIN1 Gene

Unigene Clusters for OSGIN1 Gene

Oxidative stress induced growth inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for OSGIN1 Gene

GeneLoc Exon Structure for
OSGIN1
ECgene alternative splicing isoforms for
OSGIN1

Expression for OSGIN1 Gene

mRNA expression in normal human tissues for OSGIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSGIN1 Gene

This gene is overexpressed in Liver (14.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSGIN1 Gene

SOURCE GeneReport for Unigene cluster for OSGIN1 Gene Hs.128055

mRNA Expression by UniProt/SwissProt for OSGIN1 Gene

Q9UJX0-OSGI1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.
genes like me logo Genes that share expressions with OSGIN1: view

Orthologs for OSGIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSGIN1 36
  • 99.09 (n)
  • 99.37 (a)
OSGIN1 37
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSGIN1 36
  • 87.14 (n)
  • 86.37 (a)
OSGIN1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSGIN1 36
  • 87 (n)
  • 88.05 (a)
OSGIN1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osgin1 36
  • 82.32 (n)
  • 81.76 (a)
Osgin1 16
Osgin1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSGIN1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSGIN1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osgin1 36
  • 82.32 (n)
  • 82.39 (a)
chicken
(Gallus gallus)
Aves OSGIN1 36
  • 61.36 (n)
  • 63.73 (a)
OSGIN1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSGIN1 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin1 36
  • 59.26 (n)
  • 60.26 (a)
zebrafish
(Danio rerio)
Actinopterygii osgn1 36
  • 59.28 (n)
  • 57.24 (a)
osgn1 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011390 36
  • 55.56 (n)
  • 43.33 (a)
worm
(Caenorhabditis elegans)
Secernentea F30B5.4 37
  • 25 (a)
OneToMany
Species with no ortholog for OSGIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN1 Gene

ENSEMBL:
Gene Tree for OSGIN1 (if available)
TreeFam:
Gene Tree for OSGIN1 (if available)

Paralogs for OSGIN1 Gene

Paralogs for OSGIN1 Gene

Selected SIMAP similar genes for OSGIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSGIN1: view

Variants for OSGIN1 Gene

Sequence variations from dbSNP and Humsavar for OSGIN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs13299 -- 83,965,987(-) GGTCT(A/C)CTTCC reference, stop-gained
rs173776 -- 83,965,428(-) GGGTC(C/T)GAGGC reference, synonymous-codon
rs173777 -- 83,966,569(-) GGACA(C/T)CACTG downstream-variant-500B
rs185226 -- 83,966,533(-) CCCAG(A/G)CTCTA downstream-variant-500B
rs253137 -- 83,961,783(+) TCCCC(A/G)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSGIN1 Gene

Variant ID Type Subtype PubMed ID
nsv517566 CNV Gain+Loss 19592680
nsv471106 CNV Gain 18288195
dgv2928n71 CNV Loss 21882294
nsv528396 CNV Loss 19592680
nsv907038 CNV Gain 21882294
nsv907040 CNV Loss 21882294

Relevant External Links for OSGIN1 Gene

HapMap Linkage Disequilibrium report
OSGIN1
Human Gene Mutation Database (HGMD)
OSGIN1

Disorders for OSGIN1 Gene

Relevant External Links for OSGIN1

Genetic Association Database (GAD)
OSGIN1
Human Genome Epidemiology (HuGE) Navigator
OSGIN1
genes like me logo Genes that share disorders with OSGIN1: view

No data available for UniProtKB/Swiss-Prot for OSGIN1 Gene

Publications for OSGIN1 Gene

  1. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PMID: 11459809) Huynh H.T. … Chan T.W.M. (Endocrinology 2001) 2 3 4
  2. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PMID: 14570898) Ong C.K. … Huynh H.T. (J. Biol. Chem. 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. (PMID: 17192422) Li R. … Berliner J.A. (J. Lipid Res. 2007) 3 23
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 49

Products for OSGIN1 Gene

Sources for OSGIN1 Gene

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