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OSGIN1 Gene

protein-coding   GIFtS: 51
GCID: GC16P083982

Oxidative Stress Induced Growth Inhibitor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxidative Stress Induced Growth Inhibitor 11 2     BDGI2
OKL382 3 5     Oxidative Stress-Induced Growth Inhibitor 12
Bone Marrow Stromal Cell-Derived Growth Inhibitor1 2     huOKL383
Ovary, Kidney And Liver Protein 382 3     EC 1.6.58
Pregnancy-Induced Growth Inhibitor OKL382 3     EC 2.4.2.78
Pregnancy Induced Growth Inhibitor1     EC 2.7.1.1308

External Ids:    HGNC: 300931   Entrez Gene: 299482   Ensembl: ENSG000001409617   OMIM: 6079755   UniProtKB: Q9UJX03   

Export aliases for OSGIN1 gene to outside databases

Previous GC identifers: GC16P082541 GC16P069733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSGIN1 Gene:
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is
regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release
from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules.
The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring
read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase
(MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. (provided by RefSeq,
Aug 2011)

GeneCards Summary for OSGIN1 Gene:
OSGIN1 (oxidative stress induced growth inhibitor 1) is a protein-coding gene. Diseases associated with OSGIN1 include hepatocellular carcinoma, and hypertension. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OSGIN2.

UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0
Function: Regulates the differentiation and proliferation of normal cells through the regulation of cell death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSGIN1 gene promoter:
         CREB   ER-alpha   HOXA3   FOXO3a   FOXO3   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OSGIN1 promoter sequence
   Search Chromatin IP Primers for OSGIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSGIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q23.3

OSGIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSGIN1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P083982:  view genomic region     (about GC identifiers)

Start:
83,981,887 bp from pter      End:
83,999,937 bp from pter
Size:
18,051 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0 (See protein sequence)
Recommended Name: Oxidative stress-induced growth inhibitor 1  
Size: 560 amino acids; 60849 Da
Miscellaneous: Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in
normal tissue, resulting in uncontrolled growth and formation of tumors
Sequence caution: Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Sequence=AAK01722.2;
Type=Erroneous gene model prediction;
Secondary accessions: Q52M33 Q86UQ1 Q96S88 Q9BZ70
Alternative splicing: 3 isoforms:  Q9UJX0-1   Q9UJX0-2   Q9UJX0-3   

Explore the universe of human proteins at neXtProt for OSGIN1: NX_Q9UJX0

Explore proteomics data for OSGIN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for OSGIN1 (Q9UJX0)
     AFRRAVD  SYLLSGY  PVIIVGN 


    See OSGIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_892026.1  
    ENSEMBL proteins: 
     ENSP00000456965   ENSP00000355374   ENSP00000343376   ENSP00000376983   ENSP00000462048  
     ENSP00000457157  

    OSGIN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for OSGIN1
    OriGene Protein Over-expression Lysate for OSGIN1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OSGIN1
    GenScript Custom Purified and Recombinant Proteins Services for OSGIN1
    Novus Biologicals OSGIN1 Proteins
    Novus Biologicals OSGIN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSGIN1

    OSGIN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OSGIN1
    Novus Biologicals OSGIN1 Antibodies
    Abcam antibodies for OSGIN1
    Cloud-Clone Corp. Antibodies for OSGIN1
    Search ThermoFisher Antibodies for OSGIN1
    LSBio Antibodies in human, mouse, rat for OSGIN1

    OSGIN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSGIN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSGIN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSGIN1
    Cloud-Clone Corp. CLIAs for OSGIN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9UJX0

    UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0
    Similarity: Belongs to the OKL38 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSGI1_HUMAN, Q9UJX0
    Function: Regulates the differentiation and proliferation of normal cells through the regulation of cell death
    Induction: By pregnancy

         Enzyme Numbers (IUBMB): EC 1.6.52 EC 2.7.1.1302 EC 2.4.2.72

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IDA11459809
    GO:0016491oxidoreductase activity ----
         
    OSGIN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OSGIN1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSGIN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSGIN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSGIN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSGIN1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat OSGIN1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate OSGIN1:
    hsa-miR-1207-3p hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidOSGIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSGIN1
    Predesigned siRNA for gene silencing in human, mouse, rat OSGIN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSGIN1

    Clone
    Products:
         
    OriGene clones in human, mouse for OSGIN1 (see all 11)
    OriGene ORF clones in mouse, rat for OSGIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OSGIN1 (NM_182981)
    Sino Biological Human cDNA Clone for OSGIN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGIN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSGIN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSGIN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    OSGIN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including OSGIN1: 
              Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OSGIN1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OSGIN1 (ENSP000003433764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL3ENSP000003460014STRING: ENSP00000346001
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000003992214STRING: ENSP00000399221
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0030308negative regulation of cell growth IDA11459809
    GO:0055114oxidation-reduction process ----

    OSGIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSGIN1 (OSGI1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OSGIN1 gene (3 alternative transcripts): 
    NM_182981.2  NM_013370.3  NM_182980.2  

    Unigene Cluster for OSGIN1:

    Oxidative stress induced growth inhibitor 1
    Hs.128055  [show with all ESTs]
    Unigene Representative Sequence: NM_182981
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561552 ENST00000361711 ENST00000343939(uc002fha.3 uc002fhb.3)
    ENST00000393306(uc002fhc.3) ENST00000565123 ENST00000563543 ENST00000567707

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OSGIN1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate OSGIN1:
    hsa-miR-1207-3p hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidOSGIN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSGIN1
    Predesigned siRNA for gene silencing in human, mouse, rat OSGIN1
    Clone
    Products:
         
    OriGene clones in human, mouse for OSGIN1 (see all 11)
    OriGene ORF clones in mouse, rat for OSGIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OSGIN1 (NM_182981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGIN1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OSGIN1
    OriGene qSTAR qPCR primer pairs in human, mouse for OSGIN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSGIN1
      QuantiTect SYBR Green Assays in human, mouse, rat OSGIN1
      QuantiFast Probe-based Assays in human, mouse, rat OSGIN1

    Additional mRNA sequence: 

    AF191740.1 AK290383.1 AY037158.1 AY258068.1 BC020434.1 BC032476.1 BC093687.1 BC113417.1 

    5 DOTS entries:

    DT.100766000  DT.100787074  DT.100787073  DT.95262661  DT.95262659 

    Selected AceView cDNA sequences (see all 201):

    BM718683 BM725835 AI924315 CK819852 BM142050 BC000286 CA447981 BQ186780 
    BQ721699 AA642982 BQ956581 BQ012697 AW166765 AI352381 BC020434 CD366665 
    N74699 BM976436 AA825219 AK124050 BU859877 BQ012584 AI672395 BC052592 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                    -     -     -                                             
    SP2:                    -     -     -                                             
    SP3:                          -     -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for OSGIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSGIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCGCTGG
    OSGIN1 Expression
    About this image


    OSGIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Liver (Hepatobiliary System)
    OSGIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSGIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128055

    UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0
    Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including OSGIN1: 
              Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OSGIN1
    OriGene qSTAR qPCR primer pairs in human, mouse for OSGIN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSGIN1
    QuantiTect SYBR Green Assays in human, mouse, rat OSGIN1
    QuantiFast Probe-based Assays in human, mouse, rat OSGIN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OSGIN1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osgin11 , 5 oxidative stress induced growth inhibitor 11, 5 82.32(n)1
    81.76(a)1
      8 (67.71 cM)5
    718391  NM_027950.11  NP_082226.11 
     1194341245 
    chicken
    (Gallus gallus)
    Aves OSGIN11 oxidative stress induced growth inhibitor 1 61.36(n)
    63.73(a)
      415706  XM_004944147.1  XP_004944204.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSGIN16
    oxidative stress induced growth inhibitor 1
    61(a)
    1 ↔ 1
    LGc(6922942-6936247)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia osgin11 oxidative stress induced growth inhibitor 1 59.26(n)
    60.26(a)
      100496781  XM_002935131.2  XP_002935177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii osgn11 oxidative stress induced growth inhibitor 1 59.28(n)
    57.24(a)
      393155  NM_200186.1  NP_956480.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0113901 AgaP_AGAP011390 55.56(n)
    43.33(a)
      4577558  XM_001238004.1  XP_001238005.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F30B5.46
    Protein F30B5.4 (F30B5.4) mRNA, complete cds
    25(a)
    1 → many
    IV(4205975-4218248) WBGene00017934


    ENSEMBL Gene Tree for OSGIN1 (if available)
    TreeFam Gene Tree for OSGIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSGIN1 gene
    OSGIN22  
    1 SIMAP similar gene for OSGIN1 using alignment to 4 protein entries:     OSGI1_HUMAN (see all proteins):
    OSGIN2

    OSGIN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSGIN1 (see all 639)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502632621,2
    C--83985495(+) TCCTT-/CCCTCC 1 -- us2k10--------
    rs1132707581,2
    C--83985500(+) TCCTCC/TTTCTC 1 -- us2k10--------
    rs1824724051,2
    --83985551(+) TCCCTC/GCCTTC 1 -- us2k10--------
    rs3715173421,2
    C--83995569(+) CTTTT-/TTTTTT 1 -- int10--------
    rs358427171,2
    C--83995617(+) TTAAC-/CATGAG 1 -- int10--------
    rs582920851,2
    C--83997029(+) TTGGG-/GCTTAG 1 -- int10--------
    rs22448991,2,,4
    C,F,A--84991018(-) GCACAG/TCCTGG 1 -- us2k111Minor allele frequency- T:0.12WA NA CSA EA 2541
    rs22448981,2,,4
    C,F,A--84991024(+) TGTGCG/CTGACT 1 -- us2k112Minor allele frequency- C:0.11WA NA CSA EA 2715
    rs1128423021,2
    C,F--84991031(+) GACTCC/GAGGGC 1 -- us2k13Minor allele frequency- G:0.04CSA WA NA 2509
    rs1386750151,2
    C--84991047(+) TGTGGC/G/TCACCA 1 -- us2k11NA 2548

    HapMap Linkage Disequilibrium report for OSGIN1 (83981887 - 83999937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OSGIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528396CNV Loss19592680
    dgv2928n71CNV Loss21882294
    nsv907040CNV Loss21882294
    nsv907038CNV Gain21882294
    nsv471106CNV Gain18288195
    nsv517566CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): OSGIN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSGIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for OSGIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607975    OMIM disorders: --

    5 diseases for OSGIN1:    
    About MalaCards
    hepatocellular carcinoma    hypertension    malaria    endotheliitis
    breast cancer


    OSGIN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSGIN1
    Human Genome Epidemiology (HuGE) Navigator: OSGIN1 (2 documents)

    Export disorders for OSGIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSGIN1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with OSGIN1)
        Utopia: connect your pdf to the dynamic
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    1. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PubMed id 14570898)1, 2, 3 Ong C.K.... Huynh H.T. (J. Biol. Chem. 2004)
    2. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PubMed id 11459809)1, 2, 3 Huynh H.T.... Chan T.W.M. (Endocrinology 2001)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. (PubMed id 17192422)1, 9 Li R....Berliner J.A. (J. Lipid Res. 2007)
    7. Interaction of OKL38 and p53 in regulating mitochondrial structure and function. (PubMed id 22912861)1 Hu J....Wang Y. (PLoS ONE 2012)
    8. Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. (PubMed id 21737788)1 Romanoski C.E....Lusis A.J. (Circ. Res. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling. (PubMed id 20307321)1 Li R....Hsiai T. (Part Fibre Toxicol 2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29948 HGNC: 30093 AceView: MLYCDandOKL38 Ensembl:ENSG00000140961 euGenes: HUgn29948
    ECgene: OSGIN1 H-InvDB: OSGIN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSGIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSGIN1 gene:
    Search GeneIP for patents involving OSGIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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