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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSGEP Gene

protein-coding   GIFtS: 56
GCID: GC14M020915

O-Sialoglycoprotein Endopeptidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
O-Sialoglycoprotein Endopeptidase1 2     PRSMG12
GCPL12 3     Probable O-Sialoglycoprotein Endopeptidase2
hOSGEP2 3     Probable TRNA Threonylcarbamoyladenosine Biosynthesis Protein OSGEP2
T(6)A37 Threonylcarbamoyladenosine Biosynthesis Protein OSGEP2 3     FLJ204115
KAE12     EC 3.4.24.578
OSGEP12     

External Ids:    HGNC: 180281   Entrez Gene: 556442   Ensembl: ENSG000000920947   OMIM: 6101075   UniProtKB: Q9NPF43   

Export aliases for OSGEP gene to outside databases

Previous GC identifers: GC14M018285 GC14M014702 GC14M018904 GC14M018905 GC14M019985 GC14M001036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OSGEP Gene: 
OSGEP (O-sialoglycoprotein endopeptidase) is a protein-coding gene. Diseases associated with OSGEP include pasteurellosis, and hereditary elliptocytosis. GO annotations related to this gene include metal ion binding.

UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs
that read codons beginning with adenine (By similarity)

Gene Wiki entry for OSGEP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSGEP gene promoter:
         GR   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSGEP promoter sequence
   Search SABiosciences Chromatin IP Primers for OSGEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSGEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q12

OSGEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSGEP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020915:  view genomic region     (about GC identifiers)

Start:
20,914,570 bp from pter      End:
20,923,267 bp from pter
Size:
8,698 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4 (See protein sequence)
Recommended Name: Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP  
Size: 335 amino acids; 36427 Da
Secondary accessions: Q6IAC3

Explore the universe of human proteins at neXtProt for OSGEP: NX_Q9NPF4

Explore proteomics data for OSGEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPF4

  • 4/20 DME Specific Peptides for OSGEP (Q9NPF4) (see all 20)
     YRIFGET  PSPGYNI  DTARHHR  PLVGVNH 

    OSGEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OSGEP Protein Expression
    REFSEQ proteins: NP_060277.1  
    ENSEMBL proteins: 
     ENSP00000451784   ENSP00000206542   ENSP00000451548   ENSP00000450464   ENSP00000451787  
     ENSP00000451580   ENSP00000450507  

    Human Recombinant Protein Products for OSGEP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OSGEP
    OriGene Protein Over-expression Lysate for OSGEP
    OriGene MassSpec for OSGEP 
    OriGene Custom Protein Services for OSGEP
    GenScript Custom Purified and Recombinant Proteins Services for OSGEP
    Novus Biologicals OSGEP Protein
    Novus Biologicals OSGEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSGEP 


    OSGEP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for OSGEP
    LSBio Antibodies in human, mouse, rat for OSGEP 

    Assay Products for OSGEP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSGEP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSGEP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSGEP 
    Cloud-Clone Corp. CLIAs for OSGEP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR017860 Peptidase_M22_CS
     IPR000905 Gcp-like_dom
     IPR017861 KAE1/YgjD

    Graphical View of Domain Structure for InterPro Entry Q9NPF4

    ProtoNet protein and cluster: Q9NPF4

    1 Blocks protein domain: IPB000905 Glycoprotease (M22) metalloprotease

    UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
    Similarity: Belongs to the KAE1 / YgjD family


    OSGEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSGEP_HUMAN, Q9NPF4
    Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs
    that read codons beginning with adenine (By similarity)

         Enzyme Number (IUBMB): EC 3.4.24.572

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    OSGEP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OSGEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OSGEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSGEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSGEP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSGEP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OSGEP:
    hsa-miR-137 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidOSGEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSGEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSGEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSGEP
    Sirion Biotech Customized adenovirus for overexpression of OSGEP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OSGEP (see all 8)
    OriGene ORF clones in mouse, rat for OSGEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSGEP (NM_017807)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGEP
    Sirion Biotech Customized lentivirus for stable overexpression of OSGEP 
                         Customized lentivirus expression plasmids for stable overexpression of OSGEP 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OSGEP
    Search LifeMap BioReagents cell lines for OSGEP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSGEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/74 Interacting proteins for OSGEP (Q9NPF42, 3 ENSP000002065424) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAPIN1Q6FI812, 3, ENSP000003779144MINT-8265124 I2D: score=2 STRING: ENSP00000377914
    NVLO153812, 3, ENSP000002817014MINT-8265180 I2D: score=2 STRING: ENSP00000281701
    PKP4Q995692, 3, ENSP000003744094MINT-8265216 I2D: score=2 STRING: ENSP00000374409
    TNS1Q9HBL02, 3, ENSP000001718874MINT-8265301 I2D: score=2 STRING: ENSP00000171887
    C19orf60Q96EN92, 3MINT-8265098 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--

    OSGEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSGEP

    Search CenterWatch for drugs/clinical trials and news about OSGEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSGEP gene: 
    NM_017807.3  

    Unigene Cluster for OSGEP:

    O-sialoglycoprotein endopeptidase
    Hs.525196  [show with all ESTs]
    Unigene Representative Sequence: NM_017807
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555656 ENST00000206542(uc001vxf.3) ENST00000556124 ENST00000553292
    ENST00000554249 ENST00000555223 ENST00000555785 ENST00000554915 ENST00000553640
    ENST00000554699 ENST00000488532 ENST00000556439 ENST00000556252
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSGEP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OSGEP:
    hsa-miR-137 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidOSGEP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSGEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSGEP
    Clone
    Products:
         
    OriGene clones in human, mouse for OSGEP (see all 8)
    OriGene ORF clones in mouse, rat for OSGEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSGEP (NM_017807)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGEP
    Sirion Biotech Customized lentivirus for stable overexpression of OSGEP 
                         Customized lentivirus expression plasmids for stable overexpression of OSGEP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OSGEP
    OriGene qSTAR qPCR primer pairs in human, mouse for OSGEP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSGEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSGEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGEP

    Additional mRNA sequence: 

    AB050442.1 AF052137.1 AJ271669.1 AK000418.1 BC032310.1 CR457232.1 

    22 DOTS entries:

    DT.75103706  DT.100818524  DT.100818523  DT.97811425  DT.115639  DT.91753499  DT.115641  DT.75174251 
    DT.95173278  DT.92067929  DT.100818521  DT.100702605  DT.100818519  DT.100818528  DT.95173281  DT.100818522 
    DT.120733028  DT.95173280  DT.97859185  DT.100768690  DT.91771089  DT.95222548 

    24/306 AceView cDNA sequences (see all 306):

    BM987139 CA432074 BM810133 CB125098 BM970204 AI590607 BU738809 BQ011377 
    BM717680 CD516695 CR594397 CR610109 BE278942 BM973068 CR597694 AI420132 
    CR614622 AI871968 AI824929 CR624248 AB050442 BQ011404 F10626 AI269983 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for OSGEP (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
    SP1:                                      -                       -     -     -                 -     -           -                       -     -               
    SP2:                                                                                                                                      -     -               
    SP3:                                                                                                              -                       -     -               
    SP4:                                      -                       -     -                       -     -           -                                             
    SP5:                                -     -     -     -     -     -     -     -                 -     -           -                                             

    ExUns: 12a · 12b · 12c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for OSGEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSGEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTCCTAG
    OSGEP Expression
    About this image


    See OSGEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSGEP

    SOURCE GeneReport for Unigene cluster: Hs.525196

    UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
    Tissue specificity: Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain,
    skeletal muscle and pancreas

        SABiosciences Custom PCR Arrays for OSGEP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSGEP gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osgep1 , 5 O-sialoglycoprotein endopeptidase1, 5 86.87(n)1
    93.43(a)1
      14 (26.30 cM)5
    662461  NM_133676.21  NP_598437.21 
     509064785 
    lizard
    (Anolis carolinensis)
    Reptilia OSGEP6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343220.1(1187750-1198342)
    African clawed frog
    (Xenopus laevis)
    Amphibia osgep-prov2 O-sialoglycoprotein endopeptidase 75.32(n)    BC054300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj38e022 Transcribed sequence with moderate similarity to protein more 79.06(n)    57084865 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49331 , 3 O-sialoglycoprotein endopeptidase3
    CG49331
    69(a)3
    66.67(n)1
    72.24(a)1
      72E23
    398111  NM_140623.31  NP_648880.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.11 , 3 Protein Y71H2AM.11 70(a)3
    62.69(n)1
    69.85(a)1
      III(2899103-2905602)3
    1753991  NM_065224.41  NP_497625.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAE1(YKR038C)4
    KAE11
    Highly conserved ATPase of HSP70/DnaK family; component more4
    Kae1p1
    62.54(n)1
    68.28(a)1
      11(513159-511999)4
    8539101, 4  NP_012964.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G227201 glycoprotease M22 family protein 63.34(n)
    70.69(a)
      828368  NM_118398.4  NP_194003.1 
    rice
    (Oryza sativa)
    Liliopsida Os.254882 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.21(n)    AK102487.1 


    ENSEMBL Gene Tree for OSGEP (if available)
    TreeFam Gene Tree for OSGEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/212 SNPs in OSGEP are shown (see all 212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619941731,2
    C,F--20914819(+) CAAACT/ACCTGG 1 -- int12Minor allele frequency- A:0.04NA 122
    rs1482311331,2
    --20914865(+) ACTGGC/GATAAC 1 -- int10--------
    rs786411171,2
    C,F--20914960(+) TAGCAC/TGGGAC 1 -- int12Minor allele frequency- T:0.03WA NA 238
    rs1910961181,2
    --20914962(+) GCACGG/TGACCC 1 -- int10--------
    rs1833159081,2
    --20914968(+) GACCCA/GATGCT 1 -- int10--------
    rs779998881,2
    --20915099(+) CCGTTG/TCTTAA 1 -- int10--------
    rs58070361,2
    C,F--20915103(+) TTCTTA/-AAAAA 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs735870741,2
    C,F--20915172(+) CAGCAC/TCAAAT 1 -- int13Minor allele frequency- T:0.11WA CSA 122
    rs1429541071,2
    C--20915323(+) ATGACA/TTCAGG 1 -- ut310--------
    rs1451108131,2
    C--20915362(+) GTTCCA/GATTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OSGEP (20914570 - 20923267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OSGEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv23438CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610107    OMIM disorders: --

    5 diseases for OSGEP:    About MalaCards
    pasteurellosis    hereditary elliptocytosis    renal tubular acidosis    pneumonia
    tuberculosis

    4 diseases from the University of Copenhagen DISEASES database for OSGEP:
    Renal tubular acidosis     Hereditary elliptocytosis     Shipyard eye     Pasteurellosis

    OSGEP for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSGEP
    Human Genome Epidemiology (HuGE) Navigator: OSGEP (2 documents)

    Export disorders for OSGEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSGEP gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with OSGEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes. (PubMed id 12039036)1, 2, 3 Seki Y.... Matsui H. (2002)
    2. Haplotype-based case-control study on human apurinic/ apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hyperten sion. (PubMed id 20010699)1, 4 Naganuma T....Usami R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55644 HGNC: 18028 AceView: OSGEP Ensembl:ENSG00000092094 euGenes: HUgn55644
    ECgene: OSGEP H-InvDB: OSGEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSGEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSGEP gene:
    Search GeneIP for patents involving OSGEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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