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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSGEP Gene

protein-coding   GIFtS: 54
GCID: GC14M020915

O-sialoglycoprotein endopeptidase

 Explore 8 diseases affiliated with
OSGEP via our new
 Human Malady Compendium 
Biological research products
for OSGEP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
O-Sialoglycoprotein Endopeptidase1 2     T(6)A37 Threonylcarbamoyladenosine Biosynthesis Protein OSGEP2 3
GCPL11 2 3     Probable O-Sialoglycoprotein Endopeptidase2
KAE11 2     Probable TRNA Threonylcarbamoyladenosine Biosynthesis Protein OSGEP2
OSGEP11 2     FLJ204115
PRSMG11 2     EC 3.4.24.578
HOSGEP1     

External Ids:    HGNC: 180281   Entrez Gene: 556442   Ensembl: ENSG000000920947   OMIM: 6101075   UniProtKB: Q9NPF43   

Export aliases for OSGEP gene to outside databases

Previous GC identifers: GC14M018285 GC14M014702 GC14M018904 GC14M018905 GC14M019985 GC14M001036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that
read codons beginning with adenine (By similarity)

Gene Wiki entry for OSGEP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSGEP gene promoter:
         GR   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSGEP promoter sequence
   Search SABiosciences Chromatin IP Primers for OSGEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSGEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q12

OSGEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSGEP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020915:  view genomic region     (about GC identifiers)

Start:
20,914,570 bp from pter      End:
20,923,267 bp from pter
Size:
8,698 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4 (See protein sequence)
Recommended Name: Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP  
Size: 335 amino acids; 36427 Da
Secondary accessions: Q6IAC3

Explore the universe of human proteins at neXtProt for OSGEP: NX_Q9NPF4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPF4

  • 4/20 DME Specific Peptides for OSGEP (Q9NPF4) (see all 20)
     YRIFGET  PSPGYNI  DTARHHR  PLVGVNH 

    OSGEP Protein expression data from MOPED and PaxDb:    About this image 
    OSGEP Protein Expression
    REFSEQ proteins: NP_060277.1  
    ENSEMBL proteins: 
     ENSP00000451784   ENSP00000206542   ENSP00000451548   ENSP00000450464   ENSP00000451787  
     ENSP00000451580   ENSP00000450507  

    Human Recombinant Protein Products for OSGEP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: OSGEP
    OriGene Protein Over-expression Lysate: OSGEP
    OriGene Custom Protein Services for OSGEP 
    GenScript Custom Purified and Recombinant Proteins Services for OSGEP
    Novus Biologicals OSGEP Protein
    Novus Biologicals OSGEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OSGEP


    OSGEP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): OSGEP
    OriGene Custom Antibody Services for OSGEP 
    GenScript Custom Superior Antibodies Services for OSGEP
    Novus Biologicals OSGEP Antibodies
    Abcam antibodies for OSGEP 
    Uscn Antibodies for OSGEP
    ThermoFisher Antibody for OSGEP

    Assay Products for OSGEP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSGEP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for OSGEP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OSGEP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017860 Peptidase_M22_CS
     IPR000905 Gcp-like_dom
     IPR017861 KAE1/YgjD

    Graphical View of Domain Structure for InterPro Entry Q9NPF4

    ProtoNet protein and cluster: Q9NPF4

    1 Blocks protein family: IPB000905 Glycoprotease (M22) metalloprotease

    UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
    Similarity: Belongs to the KAE1 / YgjD family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSGEP_HUMAN, Q9NPF4
    Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that
    read codons beginning with adenine (By similarity)

         Enzyme Number (IUBMB): EC 3.4.24.572

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity ----
    GO:0046872metal ion binding IEA--
         
    OSGEP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OSGEP 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: OSGEP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSGEP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OSGEP:
    hsa-miR-137 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidOSGEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSGEP (see all 7)
    OriGene shRNA RFP: OSGEP
    OriGene siRNA: OSGEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSGEP
    Sirion Biotech Custom design and validation of potent shRNA sequences against OSGEP 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSGEP
    Sirion Biotech Customized adenovirus for overexpression of OSGEP 
    Sirion Biotech Customized adenovirus for potent knockdown of OSGEP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSGEP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSGEP (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OSGEP (NM_017807)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGEP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSGEP
    Search LifeMap BioReagents cell lines for OSGEP
    Sirion Biotech Customized stable knockdown cell line services for OSGEP 
    Sirion Biotech Customized inducible knockdown cell line services for OSGEP
    Sirion Biotech Customized stable overexpressing cell line services for OSGEP
    Sirion Biotech Customized inducible overexpressing cell line services for OSGEP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSGEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/74 Interacting proteins for OSGEP (Q9NPF42, 3 ENSP000002065424) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAPIN1Q6FI812, 3, ENSP000003779144MINT-8265124 I2D: score=2 STRING: ENSP00000377914
    NVLO153812, 3, ENSP000002817014MINT-8265180 I2D: score=2 STRING: ENSP00000281701
    PKP4Q995692, 3, ENSP000003744094MINT-8265216 I2D: score=2 STRING: ENSP00000374409
    TNS1Q9HBL02, 3, ENSP000001718874MINT-8265301 I2D: score=2 STRING: ENSP00000171887
    C19orf60Q96EN92, 3MINT-8265098 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008033tRNA processing IEA--

    OSGEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSGEP
    Search CenterWatch for drugs/clinical trials and news about OSGEP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSGEP gene: 
    NM_017807.3  

    Unigene Cluster for OSGEP:

    O-sialoglycoprotein endopeptidase
    Hs.525196  [show with all ESTs]
    Unigene Representative Sequence: NM_017807
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555656 ENST00000206542(uc001vxf.3) ENST00000556124 ENST00000553292
    ENST00000554249 ENST00000555223 ENST00000555785 ENST00000554915 ENST00000553640
    ENST00000554699 ENST00000553752 ENST00000488532 ENST00000556439 ENST00000556252


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: OSGEP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSGEP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OSGEP:
    hsa-miR-137 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidOSGEP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSGEP (see all 7)
    OriGene shRNA RFP: OSGEP
    OriGene siRNA: OSGEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSGEP
    Sirion Biotech Custom design and validation of potent shRNA sequences against OSGEP 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSGEP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSGEP (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OSGEP (NM_017807)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSGEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSGEP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSGEP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSGEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSGEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGEP

    Additional cDNA sequence: 

    AB050442.1 AF052137.1 AJ271669.1 AK000418.1 BC032310.1 CR457232.1 

    22 DOTS entries:

    DT.75103706  DT.100818524  DT.100818523  DT.97811425  DT.115639  DT.91753499  DT.115641  DT.75174251 
    DT.95173278  DT.92067929  DT.100818521  DT.100702605  DT.100818519  DT.100818528  DT.95173281  DT.100818522 
    DT.120733028  DT.95173280  DT.97859185  DT.100768690  DT.91771089  DT.95222548 

    24/306 AceView cDNA sequences (see all 306):

    CR624248 BQ880839 BE278942 BE250158 AI910688 BQ011129 BQ011404 AI590607 
    H23448 AI269983 AA831409 AK000418 BU738809 BM987139 BU754007 BM973068 
    BQ011395 CF529471 BF475273 CD516695 T17353 BQ007437 CR594397 F10626 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for OSGEP (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
    SP1:                                      -                       -     -     -                 -     -           -                       -     -               
    SP2:                                                                                                                                      -     -               
    SP3:                                                                                                              -                       -     -               
    SP4:                                      -                       -     -                       -     -           -                                             
    SP5:                                -     -     -     -     -     -     -     -                 -     -           -                                             

    ExUns: 12a · 12b · 12c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for OSGEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSGEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGTCCTAG
    OSGEP Expression
    About this image
    See OSGEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSGEP

    SOURCE GeneReport for Unigene cluster: Hs.525196

    UniProtKB/Swiss-Prot: OSGEP_HUMAN, Q9NPF4
    Tissue specificity: Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal
    muscle and pancreas

        SABiosciences Custom PCR Arrays for OSGEP
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSGEP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSGEP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSGEP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSGEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSGEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for OSGEP gene from 11/40 species (see all 40)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osgep1 , 5 O-sialoglycoprotein endopeptidase1, 5 86.87(n)1
    93.43(a)1
      14 (26.30 cM)5
    662461  NM_133676.21  NP_598437.21 
     509064785 
    chicken
    (Gallus gallus)
    Aves OSGEPL16
    Uncharacterized protein
    21(a)
    possible ortholog
    7(288427-299774)
    lizard
    (Anolis carolinensis)
    Reptilia OSGEP6
    OSGEPL16
    --
    85(a)
    20(a)
    1 ↔ 1
    possible ortholog
    GL343220.1(1187750-1198334)
    2(135084634-135096001)
    African clawed frog
    (Xenopus laevis)
    Amphibia osgep-prov2 O-sialoglycoprotein endopeptidase 75.32(n)    BC054300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj38e022 Transcribed sequence with moderate similarity to protein more 79.06(n)    57084865 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49331 , 3 O-sialoglycoprotein endopeptidase3
    CG49331
    69(a)3
    66.67(n)1
    72.24(a)1
      72E23
    398111  NM_140623.31  NP_648880.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.11 , 3 Protein Y71H2AM.11 70(a)3
    62.69(n)1
    69.85(a)1
      III(2899103-2905602)3
    1753991  NM_065224.41  NP_497625.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAE1(YKR038C)4
    KAE11
    Highly conserved ATPase of HSP70/DnaK family; component more4
    Kae1p1
    62.54(n)1
    68.28(a)1
      11(513159-511999)4
    8539101, 4  NP_012964.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G227201 glycoprotease M22 family protein 63.34(n)
    70.69(a)
      828368  NM_118398.4  NP_194003.1 
    rice
    (Oryza sativa)
    Liliopsida Os.254882 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.21(n)    AK102487.1 


    ENSEMBL Gene Tree for OSGEP (if available)
    TreeFam Gene Tree for OSGEP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in OSGEP are shown (see all 164    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619941731,2
    --20914819(+) CAAACT/ACCTGG 1 -- int12Minor allele frequency- A:0.04NA 122
    rs1482311331,2
    --20914865(+) ACTGGC/GATAAC 1 -- int10--------
    rs786411171,2
    F--20914960(+) TAGCAC/TGGGAC 1 -- int12Minor allele frequency- T:0.03WA NA 238
    rs1910961181,2
    --20914962(+) GCACGG/TGACCC 1 -- int10--------
    rs1833159081,2
    --20914968(+) GACCCA/GATGCT 1 -- int10--------
    rs779998881,2
    --20915099(+) CCGTTG/TCTTAA 1 -- int10--------
    rs58070361,2
    C,F--20915103(+) TTCTTA/-AAAAA 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs735870741,2
    C,F--20915172(+) CAGCAC/TCAAAT 1 -- int13Minor allele frequency- T:0.11WA CSA 122
    rs1429541071,2
    --20915323(+) ATGACA/TTCAGG 1 -- ut310--------
    rs1451108131,2
    C--20915362(+) GTTCCA/GATTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OSGEP (20914570 - 20923267 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OSGEP
         1 CNV: 71865

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OSGEP for disorders           About GeneDecksing

    OMIM gene information: 610107    OMIM disorders: --

    8 diseases for OSGEP:    About MalaCards
    renal tubular acidosis    pasteurellosis    elliptocytosis    hereditary elliptocytosis
    pneumonia    tuberculosis    malaria    mycobacterium tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for OSGEP:
    Renal tubular acidosis     Hereditary elliptocytosis     Pasteurellosis
    Human Genome Epidemiology (HuGE) Navigator: OSGEP (2 documents)

    Export disorders for OSGEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSGEP gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with OSGEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes. (PubMed id 12039036)1, 2, 3 Seki Y.... Matsui H. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Haplotype-based case-control study on human apurinic/ apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hyperten sion. (PubMed id 20010699)1 Naganuma T....Usami R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55644 HGNC: 18028 AceView: OSGEP Ensembl:ENSG00000092094 euGenes: HUgn55644
    ECgene: OSGEP H-InvDB: OSGEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSGEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSGEP gene:
    Search GeneIP for patents involving OSGEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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