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OSER1 Gene

protein-coding   GIFtS: 34
GCID: GC20M042824

Oxidative Stress Responsive Serine-Rich 1

(Previous name: chromosome 20 open reading frame 111)
(Previous symbol: C20orf111)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxidative Stress Responsive Serine-Rich 11 2     Peroxide-Inducible Transcript 11
C20orf1111 2 3     HSPC2072
Oxidative Stress-Responsive 11 2     Osr12
Oxidative Stress-Responsive Protein 12 3     Perit12
Peroxide-Inducible Transcript 1 Protein2 3     dJ1183I21.12
Chromosome 20 Open Reading Frame 1111     Oxidative Stress-Responsive Serine-Rich Protein 12

External Ids:    HGNC: 161051   Entrez Gene: 515262   Ensembl: ENSG000001328237   UniProtKB: Q9NX313   

Export aliases for OSER1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OSER1 Gene:
OSER1 (oxidative stress responsive serine-rich 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for OSER1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OSER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.11   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.11

OSER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSER1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M042824:  view genomic region     (about GC identifiers)

Start:
42,824,579 bp from pter      End:
42,839,546 bp from pter
Size:
14,968 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSER1_HUMAN, Q9NX31 (See protein sequence)
Recommended Name: Oxidative stress-responsive serine-rich protein 1  
Size: 292 amino acids; 31779 Da
Sequence caution: Sequence=AAF36127.1; Type=Frameshift; Positions=201, 195; Sequence=AAF67625.1; Type=Frameshift;
Positions=201, 287; Sequence=BAA91191.1; Type=Frameshift; Positions=183;
Secondary accessions: B2RCK4 O95912 Q9NZ84 Q9P0R8

Explore the universe of human proteins at neXtProt for OSER1: NX_Q9NX31

Explore proteomics data for OSER1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys190
  • Modification sites at PhosphoSitePlus

  • See OSER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057554.4  
    ENSEMBL proteins: 
     ENSP00000362061   ENSP00000255174  

    OSER1 Human Recombinant Protein Products:

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    Search eBioscience for Proteins for OSER1 

     
    antibodies-online proteins for OSER1 (2 products) 

     
    antibodies-online peptides for OSER1

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    antibodies-online antibodies for OSER1 

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    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for OSER1 
    antibodies-online kits for OSER1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008494 DUF776

    Graphical View of Domain Structure for InterPro Entry Q9NX31

    ProtoNet protein and cluster: Q9NX31


    Find genes that share domains with OSER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for OSER1:
     Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OSER1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSER1
    Interactions:

        Search GeneGlobe Interaction Network for OSER1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for OSER1 (ENSP000002551744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070301cellular response to hydrogen peroxide IEA--

    Find genes that share ontologies with OSER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSER1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSER1 gene: 
    NM_016470.7  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372970 ENST00000255174(uc002xlk.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OSER1
      QuantiFast Probe-based Assays in human, mouse, rat OSER1

    Selected AceView cDNA sequences (see all 378):

    AA587896 BU608428 BQ018766 BQ029664 NM_016470 BQ647036 CR626237 AI918185 
    AK000476 AI050900 BU752589 BE746376 Z40759 AL133000 N51906 BX417627 
    AA669121 AA464859 CD743101 AV651552 BP339611 CA775876 CA411908 AI025656 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSER1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
    SP1:                          -     -                       -                                       
    SP2:              -     -     -     -     -     -           -                                       
    SP3:                                -     -     -           -                                       
    SP4:                                      -     -           -                                       
    SP5:              -     -     -     -     -     -           -     -                                 


    ECgene alternative splicing isoforms for OSER1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OSER1 Expression
    About this image


    OSER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    OSER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSER1 Protein Expression
        Custom PCR Arrays for OSER1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OSER1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3230401D17Rik5
    Oser11
    RIKEN cDNA 3230401D17 gene5
    oxidative stress responsive serine rich 11
    87.86(n)1
    86.94(a)1
      2 (84.26 cM)5
    666801  NM_025699.21  NP_079975.21 
     1634058225 
    chicken
    (Gallus gallus)
    Aves C20H20ORF1111 chromosome 20 open reading frame, human C20orf111 69.63(n)
    66.44(a)
      419203  NM_001029981.1  NP_001025152.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSER16
    oxidative stress responsive serine-rich 1
    50(a)
    1 ↔ 1
    4(144300755-144313995)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82762 Xenopus laevis transcribed sequence with weak similarity more 74.3(n)    BX850677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053184.12   -- 76.06(n)   393328  BC053184.1 


    ENSEMBL Gene Tree for OSER1 (if available)
    TreeFam Gene Tree for OSER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSER1 (see all 338)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816607421,2
    --42824141(+) CAAAAA/GTTTTG 1 -- int10--------
    rs114832311,2
    C--42824180(+) AAAAAT/-ATCTT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs339566691,2
    C--42824181(+) AAAAA-/TTCTTA 1 -- int10--------
    rs60314491,2
    C,F,A,H--42824201(+) TCTAAC/TATGGT 1 -- int122Minor allele frequency- T:0.43NS EA NA WA CSA 2349
    rs1409806321,2
    --42824418(+) CAGATA/GTCACT 1 -- int10--------
    rs1502270231,2
    --42824446(+) ATGACC/GAGCAG 1 -- int10--------
    rs1869922611,2
    --42824463(+) CCCACA/TACTAC 1 -- int10--------
    rs1918773081,2
    --42824465(+) CACTAA/CTACTT 1 -- int10--------
    rs1841183511,2
    --42824565(+) TCAACA/CACAGC 1 -- int10--------
    rs1388294521,2
    --42824588(+) AGTAAA/GTAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OSER1 (42824579 - 42839546 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OSER1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSER1
    DNA2.0 Custom Variant and Variant Library Synthesis for OSER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSER1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with OSER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. (PubMed id 17148688)1, 3 Clerk A....Sugden P.H. (Physiol. Genomics 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51526 HGNC: 16105 AceView: C20orf111 Ensembl:ENSG00000132823 euGenes: HUgn51526
    ECgene: OSER1 H-InvDB: OSER1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSER1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSER1 gene:
    Search GeneIP for patents involving OSER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Custom Antibody Services for OSER1   OriGene Custom Protein Services for OSER1  

     
     
     Block miRNA regulation of human, mouse, rat OSER1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OSER1
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     QuantiFast Probe-based Assays in human, mouse, rat OSER1 QuantiTect SYBR Green Assays in human, mouse, rat OSER1
     Custom PCR Arrays for OSER1 Search Chromatin IP Primers for OSER1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat OSER1 Search GeneGlobe Interaction Network for OSER1
     Search Regulatory tfbs for OSER1
     GenScript Custom Purified and Recombinant Proteins Services for OSER1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for OSER1
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     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search for Antibodies & Assays

     Search Tocris compounds for OSER1
     Browse Sino Biological Proteins
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for OSER1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for OSER1
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     Advantages of Rabbit Monoclonal antibodies
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OSER1
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSER1
     SwitchGear 3'UTR luciferase reporter plasmids for OSER1
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     Search ThermoFisher Antibodies for OSER1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSER1
     Browse compounds at ApexBio
     Search Addgene for plasmids for OSER1
      Search eBioscience for proteins for OSER1
      Search eBioscience for elisas for OSER1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OSER1
     antibodies-online antibodies for OSER1
     antibodies-online kits for OSER1 (2 products)
     antibodies-online peptides for OSER1
     antibodies-online proteins for OSER1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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