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Aliases for OSER1 Gene

Aliases for OSER1 Gene

  • Oxidative Stress Responsive Serine Rich 1 2 3 5
  • Peroxide-Inducible Transcript 1 Protein 3 4
  • Oxidative Stress-Responsive Protein 1 3 4
  • Oxidative Stress-Responsive 1 2 3
  • C20orf111 3 4
  • Oxidative Stress-Responsive Serine-Rich Protein 1 3
  • Oxidative Stress Responsive Serine-Rich 1 2
  • Chromosome 20 Open Reading Frame 111 2
  • Peroxide-Inducible Transcript 1 2
  • DJ1183I21.1 3
  • HSPC207 3
  • Perit1 3
  • Osr1 3

External Ids for OSER1 Gene

Previous HGNC Symbols for OSER1 Gene

  • C20orf111

Previous GeneCards Identifiers for OSER1 Gene

  • GC20M042824

Summaries for OSER1 Gene

GeneCards Summary for OSER1 Gene

OSER1 (Oxidative Stress Responsive Serine Rich 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSER1 Gene

Genomics for OSER1 Gene

Regulatory Elements for OSER1 Gene

Enhancers for OSER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F044202 1.5 FANTOM5 Ensembl ENCODE 20.5 +6.7 6693 3.0 TBP INSM2 BRCA1 DNMT3B ZEB1 RFX5 ZNF366 SCRT2 RCOR1 FOS OSER1 OSER1-AS1 JPH2
GH20F044216 1.4 FANTOM5 Ensembl ENCODE 18.4 -7.9 -7933 3.7 ELF3 ARID4B ZNF48 RAD21 ZNF143 DEK MIXL1 THAP11 ZNF654 SP5 OSER1 FITM2 LINC01430 LINC01620 OSER1-AS1 JPH2 GDAP1L1
GH20F044206 1.2 ENCODE 20.3 +1.0 1017 6.1 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 OSER1 OSER1-AS1 LINC01728 ENSG00000237555 RPL27AP FITM2 IFT52 JPH2
GH20F044965 1.8 FANTOM5 Ensembl ENCODE 12 -758.0 -758020 7.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 STK4 PCIF1 SYS1 OSER1 PABPC1L DNTTIP1 WFDC5 TOMM34 SERINC3 YWHAB
GH20F044173 1.6 FANTOM5 Ensembl ENCODE 13.1 +29.1 29120 15.7 HDGF PKNOX1 MLX YBX1 DMAP1 ZNF48 ZNF121 ZNF302 ZNF207 SMARCA4 JPH2 FITM2 OSER1 SGK2 OSER1-AS1 GC20P044130
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSER1 on UCSC Golden Path with GeneCards custom track

Promoters for OSER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001449020 1006 3801 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for OSER1 Gene

Chromosome:
20
Start:
44,195,939 bp from pter
End:
44,210,906 bp from pter
Size:
14,968 bases
Orientation:
Minus strand

Genomic View for OSER1 Gene

Genes around OSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSER1 Gene

Proteins for OSER1 Gene

  • Protein details for OSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX31-OSER1_HUMAN
    Recommended name:
    Oxidative stress-responsive serine-rich protein 1
    Protein Accession:
    Q9NX31
    Secondary Accessions:
    • B2RCK4
    • O95912
    • Q9NZ84
    • Q9P0R8

    Protein attributes for OSER1 Gene

    Size:
    292 amino acids
    Molecular mass:
    31779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36127.1; Type=Frameshift; Positions=201, 195; Evidence={ECO:0000305}; Sequence=AAF67625.1; Type=Frameshift; Positions=201, 287; Evidence={ECO:0000305}; Sequence=BAA91191.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305};

neXtProt entry for OSER1 Gene

Post-translational modifications for OSER1 Gene

  • Ubiquitination at Lys 59 and Lys 190
  • Modification sites at PhosphoSitePlus

Other Protein References for OSER1 Gene

No data available for DME Specific Peptides for OSER1 Gene

Domains & Families for OSER1 Gene

Protein Domains for OSER1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OSER1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for OSER1 Gene

Function for OSER1 Gene

genes like me logo Genes that share phenotypes with OSER1: view

Animal Model Products

miRNA for OSER1 Gene

miRTarBase miRNAs that target OSER1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSER1 Gene

Localization for OSER1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSER1 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OSER1 Gene

Pathways & Interactions for OSER1 Gene

SuperPathways for OSER1 Gene

No Data Available

Interacting Proteins for OSER1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255174%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000255174 Q9NX31-OSER1_HUMAN for OSER1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OSER1 Gene

Transcripts for OSER1 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSER1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7:

Relevant External Links for OSER1 Gene

GeneLoc Exon Structure for
OSER1
ECgene alternative splicing isoforms for
OSER1

Expression for OSER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSER1 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSER1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OSER1 Gene:

OSER1
genes like me logo Genes that share expression patterns with OSER1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OSER1 Gene

Orthologs for OSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSER1 35
  • 100 (a)
OneToOne
C20H20orf111 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia C24H20orf111 34
  • 94.29 (n)
OSER1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSER1 34 35
  • 91.64 (n)
mouse
(Mus musculus)
Mammalia Oser1 34 16 35
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Oser1 34
  • 87.4 (n)
oppossum
(Monodelphis domestica)
Mammalia OSER1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSER1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF111 34 35
  • 69.63 (n)
lizard
(Anolis carolinensis)
Reptilia OSER1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oser1 34
  • 62.51 (n)
MGC76290 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8276 34
zebrafish
(Danio rerio)
Actinopterygii oser1 34 35
  • 54.8 (n)
-- 34
Species where no ortholog for OSER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSER1 Gene

ENSEMBL:
Gene Tree for OSER1 (if available)
TreeFam:
Gene Tree for OSER1 (if available)

Paralogs for OSER1 Gene

No data available for Paralogs for OSER1 Gene

Variants for OSER1 Gene

Sequence variations from dbSNP and Humsavar for OSER1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1007125 -- 44,208,717(-) GGAAG(A/G)ATTTG intron-variant, upstream-variant-2KB
rs10626085 -- 44,211,951(+) TAGTC(-/AACT)AACTA intron-variant, upstream-variant-2KB
rs10664913 -- 44,218,602(+) AACTA(-/AG)AGAAG intron-variant, upstream-variant-2KB
rs10664983 -- 44,218,603(+) TAAGA(-/GA)AGTGT intron-variant, upstream-variant-2KB
rs111317560 -- 44,202,456(+) CCATT(A/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSER1 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958
nsv507908 OTHER sequence alteration 20534489

Variation tolerance for OSER1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.40; 92.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSER1 Gene

Human Gene Mutation Database (HGMD)
OSER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSER1 Gene

Disorders for OSER1 Gene

Relevant External Links for OSER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSER1

No disorders were found for OSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSER1 Gene

Publications for OSER1 Gene

  1. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. (PMID: 17148688) Clerk A. … Sugden P.H. (Physiol. Genomics 2007) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for OSER1 Gene

Sources for OSER1 Gene

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