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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSCP1 Gene

protein-coding   GIFtS: 49
GCID: GC01M036881

Organic Solute Carrier Partner 1

(Previous name: chromosome 1 open reading frame 102)
(Previous symbol: C1orf102)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Organic Solute Carrier Partner 11 2     Oxidored-Nitro Domain-Containing Protein 12 3
C1orf1021 2 3     hOSCP12 3
NOR12 3 5     Chromosome 1 Open Reading Frame 1021
Oxidored Nitro Domain Containing Protein1 2     Organic Solute Carrier Protein 12
Organic Solute Transport Protein 12 3     Protein OSCP12

External Ids:    HGNC: 299711   Entrez Gene: 1277002   Ensembl: ENSG000001168857   OMIM: 6088545   UniProtKB: Q8WVF13   

Export aliases for OSCP1 gene to outside databases

Previous GC identifers: GC01M036658 GC01M035001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OSCP1 Gene: 
OSCP1 (organic solute carrier partner 1) is a protein-coding gene. Diseases associated with OSCP1 include nasopharynx carcinoma, and nasopharyngitis.

UniProtKB/Swiss-Prot: OSCP1_HUMAN, Q8WVF1
Function: May be involved in drug clearance in the placenta




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OSCP1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OSCP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

OSCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSCP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M036881:  view genomic region     (about GC identifiers)

Start:
36,881,428 bp from pter      End:
36,916,086 bp from pter
Size:
34,659 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSCP1_HUMAN, Q8WVF1 (See protein sequence)
Recommended Name: Protein OSCP1  
Size: 389 amino acids; 44586 Da
Subcellular location: Basal cell membrane. Note=Syncytiotrophoblast in placenta
Miscellaneous: May be involved in the development and/or progression of nosopharyngeal carcinoma
Caution: The polymorphism 'Glu58Gly' (described in PubMed:12819961) is in fact an error, the G to A change
described representing a synonymous mutation that does not induce any amino acid change in Gly-32
Sequence caution: Sequence=AAL89738.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NHM5 A6NHS9 A6NIN9 Q4AEJ0 Q8N7G2 Q8TDF1
Alternative splicing: 4 isoforms:  Q8WVF1-1   Q8WVF1-2   Q8WVF1-3   Q8WVF1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSCP1: NX_Q8WVF1

Explore proteomics data for OSCP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVF1

  • OSCP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OSCP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_659484.4  NP_996668.1  

    ENSEMBL proteins: 
     ENSP00000426981   ENSP00000235532   ENSP00000349052   ENSP00000390820   ENSP00000396417  
     ENSP00000346216   ENSP00000434268   ENSP00000314541  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for OSCP1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009925basal plasma membrane IEA--

    OSCP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019332 OSCP1

    Graphical View of Domain Structure for InterPro Entry Q8WVF1

    ProtoNet protein and cluster: Q8WVF1


    OSCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSCP1_HUMAN, Q8WVF1
    Function: May be involved in drug clearance in the placenta
    Biophysicochemical properties: Kinetic parameters: KM=35.0 uM for p-aminohippurate (PAH); KM=62.3 uM for
    tetraethylammonium; Note=In Xenopus laevis oocytes, in a sodium-independent manner;

    Phenotypes:
         1 GenomeRNAi human phenotype for OSCP1:

     Metaphase cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidOSCP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSCP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OSCP1 (ENSP000003490524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2HENSP000002962234STRING: ENSP00000296223
    PRAMEF3ENSP000003653434STRING: ENSP00000365343
    TSPAN2ENSP000003585294STRING: ENSP00000358529
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    OSCP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSCP1

    1 HMDB Compound for OSCP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about OSCP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSCP1 gene (2 alternative transcripts): 
    NM_145047.4  NM_206837.2  

    Unigene Cluster for OSCP1:

    Organic solute carrier partner 1
    Hs.202207  [show with all ESTs]
    Unigene Representative Sequence: NM_145047
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468441 ENST00000495222 ENST00000235532(uc001caq.3) ENST00000356637
    ENST00000471369 ENST00000433045 ENST00000445843 ENST00000475160 ENST00000525869
    ENST00000528112 ENST00000354267(uc001car.3) ENST00000524789 ENST00000315643(uc021olk.1)

    miRNA
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    hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-103a hsa-miR-424 hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidOSCP1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB079075.1 AF086535.1 AK098541.1 BC018069.1 

    11 DOTS entries:

    DT.100022251  DT.95167493  DT.209537  DT.100760309  DT.95167490  DT.121411042  DT.40259916  DT.40219249 
    DT.91742867  DT.97797291  DT.97841375 

    24/122 AceView cDNA sequences (see all 122):

    BU685895 BM671302 BM712581 AW172740 W95787 CA423179 BX119837 CR599022 
    CB243113 AI758761 BF691288 AK098541 AI968915 AI365154 AW264844 AI915821 
    AI638296 NM_145047 BP371346 BX398771 AA970257 AI637866 CK724973 NM_206837 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OSCP1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:              -     -                                   -     -                                   -                 -                     
    SP2:                                                        -     -                                   -                                       
    SP3:                    -                                   -     -                                   -                                       
    SP4:                                                        -     -                                   -     -     -     -                     
    SP5:              -     -           -                       -     -                                                                           


    ECgene alternative splicing isoforms for OSCP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSCP1 expression in normal human tissues (normalized intensities)      OSCP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGAATG
    OSCP1 Expression
    About this image


    OSCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             heart/ventricle   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See OSCP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSCP1

    SOURCE GeneReport for Unigene cluster: Hs.202207

    UniProtKB/Swiss-Prot: OSCP1_HUMAN, Q8WVF1
    Tissue specificity: Expressed predominantly in testis, also found in placenta and to a lesser extent in thymus and
    small intestine; abundantly expressed in tumor-derived cell lines (PubMed:16006562). Ubiquitously expressed
    (PubMed:12819961)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OSCP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oscp11 , 5 organic solute carrier partner 11, 5 85.49(n)1
    86.81(a)1
      4 (59.82 cM)5
    2307511  NM_172701.21  NP_766289.21 
     1260585655 
    chicken
    (Gallus gallus)
    Aves OSCP11 organic solute carrier partner 1 76.52(n)
    81.27(a)
      428220  XM_001233000.1  XP_001233001.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSCP16
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343610.1(320872-330964)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982593.12   -- 76.02(n)    CA982593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003346081 protein OSCP1-like 70.36(n)
    75.46(a)
      100334608  XM_003201606.1  XP_003201654.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG131786
    --
    25(a)
    1 ↔ 1
    2R(8030696-8032038)
    worm
    (Caenorhabditis elegans)
    Secernentea R10F2.51 Protein R10F2.5 50.53(n)
    38.95(a)
      187786  NM_065239.1  NP_497640.1 


    ENSEMBL Gene Tree for OSCP1 (if available)
    TreeFam Gene Tree for OSCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/779 SNPs in OSCP1 are shown (see all 779)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854804851,2
    --36883082(+) TCTTGG/TTATAC 1 -- int10--------
    rs133754171,2
    C,F,H--36883090(+) TACATG/TTCAGT 1 -- int19Minor allele frequency- T:0.02NS EA NA 1086
    rs1397103831,2
    --36883099(+) GTATGA/GGATAA 1 -- int10--------
    rs1452907661,2
    --36883113(+) GACACC/TGCATG 1 -- int10--------
    rs1476311941,2
    --36883130(+) CGGACA/GTGCGG 1 -- int10--------
    rs740645401,2
    C--36883431(+) CCTTAC/TCCACT 1 -- int12Minor allele frequency- T:0.10WA 120
    rs770197031,2
    C--36883624(+) ATAGAC/TGTAAT 1 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs1406153141,2
    C--36883625(+) TAGACA/GTAATG 1 -- ut310--------
    rs1420478731,2
    C--36883746(+) TATAAC/TTCATC 2 E syn10--------
    rs1511479351,2
    --36883786(+) TGGTGC/TTCAGC 2 N S mis10--------

    HapMap Linkage Disequilibrium report for OSCP1 (36881428 - 36916086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OSCP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509202CNV Insertion20534489
    dgv47e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OSCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for OSCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608854    OMIM disorders: --

    2 diseases for OSCP1:    About MalaCards
    nasopharynx carcinoma    nasopharyngitis

    1 disease from the University of Copenhagen DISEASES database for OSCP1:
    Nasopharynx carcinoma

    OSCP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSCP1
    Human Genome Epidemiology (HuGE) Navigator: OSCP1 (1 document)

    Export disorders for OSCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSCP1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with OSCP1)
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    1. Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line. (PubMed id 12819961)1, 2, 9 Nie X.... Li G. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. (PubMed id 16006562)1, 2 Kobayashi Y.... Yamamoto T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal car cinoma. (PubMed id 19727524)1, 9 Xiang B....Li G. (2009)
    8. Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
    9. NOR1 is an HSF1- and NRF1-regulated putative tumor su ppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma. (PubMed id 21803736)1 Li W....Li G. (2011)
    10. [Effects of a novel gene NOR(1) on the protein expression of HepG2 cell line.] (PubMed id 18237537)1 Nie X.M....Tang H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127700 HGNC: 29971 AceView: NOR1 Ensembl:ENSG00000116885 euGenes: HUgn127700
    ECgene: OSCP1 H-InvDB: OSCP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSCP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSCP1 gene:
    Search GeneIP for patents involving OSCP1

    GeneCards and IP:
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