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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSCAR Gene

protein-coding   GIFtS: 54
GCID: GC19M054597

Osteoclast Associated, Immunoglobulin-Like Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Osteoclast Associated, Immunoglobulin-Like Receptor1 2     Osteoclast Associated Receptor OSCAR-S22
Poly-Ig Receptor 32 3     Osteoclast-Associated Immunoglobulin-Like Receptor2
Polymeric Immunoglobulin Receptor 32 3     PIgR33
PIgR-32 3     hOSCAR3
PIGR32     Osteoclast-Associated Receptor3
Osteoclast Associated Receptor OSCAR-S12     

External Ids:    HGNC: 299601   Entrez Gene: 1260142   Ensembl: ENSG000001709097   OMIM: 6068625   UniProtKB: Q8IYS53   

Export aliases for OSCAR gene to outside databases

Previous GC identifers: GC19M055243 GC19M055022 GC19M059273 GC19M059289 GC19M050913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSCAR Gene:
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an
osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that
plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play
a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for OSCAR Gene: 
OSCAR (osteoclast associated, immunoglobulin-like receptor) is a protein-coding gene. Diseases associated with OSCAR include decubitus ulcer, and microphthalmia. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast
differentiation (By similarity)

Gene Wiki entry for OSCAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSCAR gene promoter:
         NF-1   NF-1/L   AP-1   AML1a   Pax-2   Pax-2a   YY1   PPAR-gamma1   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSCAR promoter sequence
   Search SABiosciences Chromatin IP Primers for OSCAR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSCAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

OSCAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSCAR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054597:  view genomic region     (about GC identifiers)

Start:
54,597,933 bp from pter      End:
54,606,000 bp from pter
Size:
8,068 bases      Orientation:
minus strand

6/8 alternative locations (see all 8):
Chr19-,NW_003571054 69,046-75,261      Chr19-,NW_003571056 69,046-75,261      Chr19-,NW_003571055 69,046-75,261     
Chr19-,NW_003571061 69,046-75,261      Chr19-,NW_003571059 69,046-75,261      Chr19-,NW_003571058 69,046-75,261     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5 (See protein sequence)
Recommended Name: Osteoclast-associated immunoglobulin-like receptor precursor  
Size: 282 amino acids; 30481 Da
Subcellular location: Isoform 1: Secreted (Potential)
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B7WNS2 Q5GRG5 Q8N763 Q8NHL4 Q8WXQ0 Q8WXQ1 Q8WXQ2
Alternative splicing: 7 isoforms:  Q8IYS5-1   Q8IYS5-2   Q8IYS5-3   Q8IYS5-4   Q8IYS5-5   Q8IYS5-7   Q8IYS5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSCAR: NX_Q8IYS5

Explore proteomics data for OSCAR at MOPED 

OSCAR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OSCAR Protein Expression

REFSEQ proteins (6 alternative transcripts): 
NP_001269278.1  NP_001269279.1  NP_570127.3  NP_573398.2  NP_573399.2  NP_996554.2  

ENSEMBL proteins: 
 ENSP00000375641   ENSP00000348927   ENSP00000352671   ENSP00000351145   ENSP00000304523  
 ENSP00000365808   ENSP00000375640  

Human Recombinant Protein Products for OSCAR: 
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Novus Biologicals OSCAR Proteins
Novus Biologicals OSCAR Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for OSCAR 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

OSCAR for ontologies           About GeneDecksing



OSCAR Antibody Products: 
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Abcam antibodies for OSCAR
Cloud-Clone Corp. Antibodies for OSCAR 
ThermoFisher Antibodies for OSCAR
LSBio Antibodies in human, mouse, rat for OSCAR 

Assay Products for OSCAR: 
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Cloud-Clone Corp. ELISAs for OSCAR 
Cloud-Clone Corp. CLIAs for OSCAR


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

2 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q8IYS5

ProtoNet protein and cluster: Q8IYS5

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Similarity: Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


OSCAR for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OSCAR_HUMAN, Q8IYS5
Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast
differentiation (By similarity)

Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oscar):

 cellular  hematopoietic system  immune system  skeleton 

OSCAR for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Oscartm1Ywc for OSCAR

   inGenious Targeting Laboratory - Custom generated mouse model solutions for OSCAR 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OSCAR

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSCAR 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSCAR 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSCAR
1 QIAGEN miScript miRNA Assays for microRNA that regulate OSCAR:
hsa-miR-1321
SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSCAR

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for OSCAR
Sirion Biotech Customized adenovirus for overexpression of OSCAR

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for OSCAR (see all 25)
OriGene ORF clones in mouse, rat for OSCAR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): OSCAR (NM_130771)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSCAR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR
Sirion Biotech Customized lentivirus for stable overexpression of OSCAR 
                     Customized lentivirus expression plasmids for stable overexpression of OSCAR 

Cell Line
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Search LifeMap BioReagents cell lines for OSCAR
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSCAR


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OSCAR About                                                                                                See pathways by source

SuperPathContained pathways About
1Osteoclast differentiation
Osteoclast differentiation

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1         Kegg Pathway  (Kegg details for OSCAR):
    Osteoclast differentiation


OSCAR for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSCAR

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for OSCAR (Q8IYS53 ENSP000003526714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
FCARP240713, ENSP000003477144I2D: score=1 STRING: ENSP00000347714
FCGR2AENSP000002714504STRING: ENSP00000271450
FCGR3AENSP000003569464STRING: ENSP00000356946
FCGR3BENSP000002948004STRING: ENSP00000294800
SYKENSP000003648984STRING: ENSP00000364898
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OSCAR for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OSCAR

1 Novoseek inferred chemical compound relationship for OSCAR gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 0 2 16046394 (1), 16109714 (1)

Search CenterWatch for drugs/clinical trials and news about OSCAR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OSCAR gene (7 alternative transcripts): 
NM_001282349.1  NM_001282350.1  NM_130771.4  NM_133168.4  NM_133169.4  NM_206818.2  NM_206817.1  

Unigene Cluster for OSCAR:

Osteoclast associated, immunoglobulin-like receptor
Hs.347655  [show with all ESTs]
Unigene Representative Sequence: BC035023
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000391761 ENST00000356532 ENST00000359649 ENST00000358375 ENST00000351806
ENST00000284648(uc002qcy.3 uc002qcz.3 uc002qda.3 uc002qdb.3 uc010erc.3 uc002qdc.3 uc002qdd.3)
ENST00000391760
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSCAR
1 QIAGEN miScript miRNA Assays for microRNA that regulate OSCAR:
hsa-miR-1321
SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for OSCAR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSCAR
Clone
Products:
     
OriGene clones in human, mouse for OSCAR (see all 25)
OriGene ORF clones in mouse, rat for OSCAR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): OSCAR (NM_130771)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSCAR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR
Sirion Biotech Customized lentivirus for stable overexpression of OSCAR 
                     Customized lentivirus expression plasmids for stable overexpression of OSCAR 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for OSCAR
OriGene qSTAR qPCR primer pairs in human, mouse for OSCAR
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSCAR
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSCAR
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSCAR

Additional mRNA sequence: 

AF251702.1 AF391162.1 AF391163.1 AF391164.1 AF474152.1 AF474153.1 AK091111.1 AK130199.1 
AK311307.1 BC035023.2 

7 DOTS entries:

DT.95117024  DT.95160600  DT.97838145  DT.91850607  DT.100021891  DT.97838147  DT.438842 

24/48 AceView cDNA sequences (see all 48):

NM_130771 AF391163 AF391164 NM_133168 NM_206818 AF391162 AA321203 NM_206817 
NM_133169 CR613625 CB139698 CB138806 AK130199 AK091111 CB149498 CB132199 
BI518709 CA306426 AX746784 BM549768 CK430091 AA974396 BI523847 BI765408 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1:                    -     -     -     -                             -                     
SP2:                                -     -                             -                     
SP3:                          -                                                               
SP4:                    -     -     -     -                                                   
SP5:                                -                                                         


ECgene alternative splicing isoforms for OSCAR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OSCAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCGGGGACA
OSCAR Expression
About this image


See OSCAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSCAR

SOURCE GeneReport for Unigene cluster: Hs.347655
    SABiosciences Custom PCR Arrays for OSCAR
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSCAR
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSCAR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Oscar1 , 5 osteoclast associated receptor1, 5 76.21(n)1
74.43(a)1
  7 (2.08 cM)5
2327901  NM_175632.21  NP_783440.11 
 36098135 
chicken
(Gallus gallus)
Aves --
--
(see all 62)
--
31(a)
30(a)
(see all 62)
many ↔ many
many ↔ many
(see all 62)
JH376121.1(3529-4219)
AADN03012120.1(25-1435)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
9(a)
8(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343329.1(1197670-1218701)
GL343329.1(823590-844642)


ENSEMBL Gene Tree for OSCAR (if available)
TreeFam Gene Tree for OSCAR (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OSCAR gene
LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
FCAR2  GP62  LILRB32  
1 SIMAP similar gene for OSCAR using alignment to 2 protein entries:     OSCAR_HUMAN (see all proteins):
LAIR2

OSCAR for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/204 SNPs in OSCAR are shown (see all 204)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1856983441,2
--50922072(+) GCAGGC/TTCCGG 4 -- us2k10--------
rs2542601,2
C,F,A,H--50922073(-) ACCGGC/AACCTG 4 -- us2k129Minor allele frequency- A:0.10EA NA NS WA CSA EU 2632
rs2001407491,2
C--50922075(+) GGTTCC/TGGTGG 4 -- us2k10--------
rs1853752671,2
--54597467(+) CCCGGA/GAGGCG 4 -- ds50010--------
rs1913139071,2
--54597489(+) GAACCA/GAGATC 4 -- ds50010--------
rs6447471,2
C,F--54597545(-) TCTTTT/CTTTTT 4 -- ds50016Minor allele frequency- C:0.11WA NA EA 364
rs1173597111,2
F--54597676(+) ACTACG/AGGCCA 4 -- ds50011Minor allele frequency- A:0.01NA 120
rs789282371,2
C,F--54597720(+) ACTGAA/CTCCTA 4 -- ds50011Minor allele frequency- C:0.04NA 120
rs800414351,2
C,F--54597853(+) TTGTGG/CTCTCG 4 -- ds50012Minor allele frequency- C:0.08WA EA 238
rs1494889041,2
--54597932(+) AAAGAC/GTTAGC 4 -- ds50010--------

HapMap Linkage Disequilibrium report for OSCAR (54597933 - 54606000 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for OSCAR:    About this table     
Variant IDTypeSubtypePubMed ID
esv2718812CNV Deletion23290073
esv1149991CNV Insertion17803354
nsv2542CNV Loss18451855
nsv470157CNV Loss18288195
nsv510773CNV Loss20534489
nsv833877CNV Loss17160897
nsv182CNV Loss15895083
dgv4001n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing OSCAR
DNA2.0 Custom Variant and Variant Library Synthesis for OSCAR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606862    OMIM disorders: --

8 diseases for OSCAR:    About MalaCards
decubitus ulcer    microphthalmia    down syndrome    hepatitis b
rheumatoid arthritis    arthritis    hepatitis    endotheliitis

1 disease from the University of Copenhagen DISEASES database for OSCAR:
Decubitus ulcer

OSCAR for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for OSCAR gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
microphthalmia 63.6 2 16109714 (2)
necrosis 20.9 1 18821671 (1)
tumors 0 1 18821671 (1)

Genetic Association Database (GAD): OSCAR
Human Genome Epidemiology (HuGE) Navigator: OSCAR (9 documents)

Export disorders for OSCAR gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OSCAR gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with OSCAR)
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  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PubMed id 11805147)1, 2, 3, 9 Kim N.... Choi Y. (2002)
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PubMed id 18821671)1, 9 Herman S....Schett G. (2008)
  5. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PubMed id 16109714)1, 9 Kim K....Kim N. (2005)
  6. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PubMed id 16007331)1, 9 Kim G.S....Shin H.D. (2005)
  7. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. (PubMed id 15155468)1, 9 Merck E....Bates E.E. (2004)
  8. The effect of rotative stress on CAII, FAS, FASL, OSCA R, and TRAP gene expression in osteoclasts. (PubMed id 22949349)1 Qing Hong Z....Li L. (2013)
  9. Quantitative proteomics reveals novel functions of ost eoclast-associated receptor in STAT signaling and cell adhesion in human endothe lial cells. (PubMed id 22985931)1 Goettsch C....Kalkhof S. (2012)
  10. Genetic association with overall survival of taxane-tr eated lung cancer patients - a genome-wide association study in human lymphoblas toid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 126014 HGNC: 29960 AceView: OSCAR Ensembl:ENSG00000170909 euGenes: HUgn126014
ECgene: OSCAR Kegg: 126014 H-InvDB: OSCAR

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OSCAR Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OSCAR gene:
Search GeneIP for patents involving OSCAR

GeneCards and IP:
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