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Aliases for OSCAR Gene

Aliases for OSCAR Gene

  • Osteoclast Associated, Immunoglobulin-Like Receptor 2 3
  • Polymeric Immunoglobulin Receptor 3 3 4
  • Poly-Ig Receptor 3 3 4
  • PIgR-3 3 4
  • PIGR3 3 4
  • Osteoclast-Associated Immunoglobulin-Like Receptor 3
  • Osteoclast Associated Receptor OSCAR-S1 3
  • Osteoclast Associated Receptor OSCAR-S2 3
  • Osteoclast-Associated Receptor 4
  • HOSCAR 4

External Ids for OSCAR Gene

Previous GeneCards Identifiers for OSCAR Gene

  • GC19M055243
  • GC19M055022
  • GC19M059273
  • GC19M059289
  • GC19M054597
  • GC19M050913

Summaries for OSCAR Gene

Entrez Gene Summary for OSCAR Gene

  • Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for OSCAR Gene

OSCAR (Osteoclast Associated, Immunoglobulin-Like Receptor) is a Protein Coding gene. Diseases associated with OSCAR include decubitus ulcer. Among its related pathways are Osteoclast differentiation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for OSCAR Gene

  • Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Wiki entry for OSCAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSCAR Gene

Genomics for OSCAR Gene

Regulatory Elements for OSCAR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSCAR Gene

54,094,668 bp from pter
54,102,692 bp from pter
8,025 bases
Minus strand

Genomic View for OSCAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSCAR Gene

Proteins for OSCAR Gene

  • Protein details for OSCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Protein Accession:
    Secondary Accessions:
    • B7WNS2
    • Q5GRG5
    • Q8N763
    • Q8NHL4
    • Q8WXQ0
    • Q8WXQ1
    • Q8WXQ2

    Protein attributes for OSCAR Gene

    282 amino acids
    Molecular mass:
    30481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSCAR Gene

neXtProt entry for OSCAR Gene

Proteomics data for OSCAR Gene at MOPED

Post-translational modifications for OSCAR Gene

  • Glycosylation at Asn48 and Asn145

Antibody Products

No data available for DME Specific Peptides for OSCAR Gene

Domains for OSCAR Gene

Gene Families for OSCAR Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for OSCAR Gene


Suggested Antigen Peptide Sequences for OSCAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IYS5
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
genes like me logo Genes that share domains with OSCAR: view

Function for OSCAR Gene

Molecular function for OSCAR Gene

UniProtKB/Swiss-Prot Function:
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Ontology (GO) - Molecular Function for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OSCAR: view
genes like me logo Genes that share phenotypes with OSCAR: view

Animal Models for OSCAR Gene

MGI Knock Outs for OSCAR:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSCAR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OSCAR Gene

Localization for OSCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSCAR Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for OSCAR Gene COMPARTMENTS Subcellular localization image for OSCAR gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSCAR: view

Pathways for OSCAR Gene

SuperPathways for OSCAR Gene

Superpath Contained pathways
1 Osteoclast differentiation
genes like me logo Genes that share pathways with OSCAR: view

Pathways by source for OSCAR Gene

1 KEGG pathway for OSCAR Gene

Interacting Proteins for OSCAR Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000352671 Q8IYS5-OSCAR_HUMAN for OSCAR Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OSCAR Gene


Compounds for OSCAR Gene

(1) Novoseek inferred chemical compound relationships for OSCAR Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with OSCAR: view

Transcripts for OSCAR Gene

Unigene Clusters for OSCAR Gene

Osteoclast associated, immunoglobulin-like receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSCAR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for OSCAR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSCAR Gene

mRNA expression in normal human tissues for OSCAR Gene

mRNA differential expression in normal tissues according to GTEx for OSCAR Gene

This gene is overexpressed in Whole Blood (35.1).

Protein differential expression in normal tissues for OSCAR Gene

This gene is overexpressed in Urine (54.4), Serum (7.4), and Monocytes (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OSCAR Gene

SOURCE GeneReport for Unigene cluster for OSCAR Gene Hs.347655

genes like me logo Genes that share expressions with OSCAR: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OSCAR Gene

Orthologs for OSCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSCAR 35
  • 84.56 (n)
  • 80.15 (a)
  • 72 (a)
(Canis familiaris)
Mammalia OSCAR 35
  • 83.2 (n)
  • 78.8 (a)
  • 69 (a)
(Mus musculus)
Mammalia Oscar 35
  • 75.2 (n)
  • 73.6 (a)
Oscar 16
Oscar 36
  • 65 (a)
(Pan troglodytes)
Mammalia OSCAR 35
  • 99.13 (n)
  • 98.88 (a)
  • 86 (a)
(Rattus norvegicus)
Mammalia Oscar 35
  • 73.2 (n)
  • 70 (a)
(Monodelphis domestica)
Mammalia OSCAR 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia OSCAR 36
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
Species with no ortholog for OSCAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSCAR Gene

Gene Tree for OSCAR (if available)
Gene Tree for OSCAR (if available)

Paralogs for OSCAR Gene

Selected SIMAP similar genes for OSCAR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSCAR: view

Variants for OSCAR Gene

Sequence variations from dbSNP and Humsavar for OSCAR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs644747 -- 54,094,280(-) TCTTT(C/T)TTTTT downstream-variant-500B
rs661239 -- 54,097,629(+) TTGCT(C/G)TGTTG intron-variant
rs661676 -- 54,099,882(-) tgagc(C/T)gagat intron-variant
rs662133 -- 54,097,835(+) ggctc(A/G)agcaa intron-variant
rs663569 -- 54,098,213(+) AAACT(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSCAR Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv510773 CNV Loss 20534489
nsv182 CNV Loss 15895083
nsv2542 CNV Loss 18451855
nsv470157 CNV Loss 18288195
dgv4001n71 CNV Loss 21882294
esv1149991 CNV Insertion 17803354

Relevant External Links for OSCAR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSCAR Gene

Disorders for OSCAR Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OSCAR Gene in MalaCards »

(1) Diseases for OSCAR Gene including...

(1) University of Copenhagen DISEASES for OSCAR Gene

(3) Novoseek inferred disease relationships for OSCAR Gene

Disease -log(P) Hits PubMed IDs
microphthalmia 63.6 2
necrosis 20.9 1
tumors 0 1

Relevant External Links for OSCAR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OSCAR: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for OSCAR Gene

Publications for OSCAR Gene

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PMID: 11805147) Kim N. … Choi Y. (J. Exp. Med. 2002) 2 3 4 23
  2. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. (PMID: 15155468) Merck E. … Bates E.E. (Blood 2004) 3 23
  3. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PMID: 16007331) Kim G.S. … Shin H.D. (J. Bone Miner. Res. 2005) 3 23
  4. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PMID: 16109714) Kim K. … Kim N. (J. Biol. Chem. 2005) 3 23
  5. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PMID: 18821671) Herman S. … Schett G. (Arthritis Rheum. 2008) 3 23

Products for OSCAR Gene

Sources for OSCAR Gene

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