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Aliases for OSCAR Gene

Aliases for OSCAR Gene

  • Osteoclast Associated, Immunoglobulin-Like Receptor 2 3 5
  • Polymeric Immunoglobulin Receptor 3 3 4
  • Poly-Ig Receptor 3 3 4
  • PIgR-3 3 4
  • PIGR3 3 4
  • Osteoclast-Associated Immunoglobulin-Like Receptor 3
  • Osteoclast Associated Receptor OSCAR-S1 3
  • Osteoclast Associated Receptor OSCAR-S2 3
  • Osteoclast-Associated Receptor 4
  • HOSCAR 4

External Ids for OSCAR Gene

Previous GeneCards Identifiers for OSCAR Gene

  • GC19M055243
  • GC19M055022
  • GC19M059273
  • GC19M059289
  • GC19M054597
  • GC19M050913

Summaries for OSCAR Gene

Entrez Gene Summary for OSCAR Gene

  • Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for OSCAR Gene

OSCAR (Osteoclast Associated, Immunoglobulin-Like Receptor) is a Protein Coding gene. Diseases associated with OSCAR include Mucinous Tubular And Spindle Renal Cell Carcinoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is IGSF1.

UniProtKB/Swiss-Prot for OSCAR Gene

  • Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Wiki entry for OSCAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSCAR Gene

Genomics for OSCAR Gene

Regulatory Elements for OSCAR Gene

Enhancers for OSCAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F054270 1.4 FANTOM5 Ensembl ENCODE 14 -169.2 -169209 2.2 ZNF316 PKNOX1 NFE2 CUX1 LAIR1 LILRB2 OSCAR MYADM LILRB3 LILRB1 LILRA5 VSTM1 LILRB4 NLRP12
GH19F054102 1 ENCODE 13.6 -0.3 -251 1.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 CDC42EP5 OSCAR ZNF765 ZNF813 NDUFA3 CNOT3 LOC105372458
GH19F054018 1 FANTOM5 Ensembl ENCODE 11.7 +81.6 81575 6.8 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GTF3C2 ZNF302 ZNF143 SP5 JUNB LILRB3 ZNF845 ZNF525 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF765 PRPF31 VSTM1 LILRA5
GH19F054114 0.7 ENCODE 10.6 -12.5 -12500 2.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF765 PRPF31 CDC42EP5 ENSG00000269288 ZNF347 ZNF665 OSCAR ENSG00000235681 ZNF813 NDUFA3
GH19F054373 0.8 FANTOM5 ENCODE 10.5 -272.2 -272226 2.7 PKNOX1 TBL1XR1 EBF1 RELA YY1 ZNF316 EED ZNF143 ETV6 NFE2 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OSCAR on UCSC Golden Path with GeneCards custom track

Promoters for OSCAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045440 -408 1801 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263

Genomic Location for OSCAR Gene

Chromosome:
19
Start:
54,094,668 bp from pter
End:
54,102,692 bp from pter
Size:
8,025 bases
Orientation:
Minus strand

Genomic View for OSCAR Gene

Genes around OSCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSCAR Gene

Proteins for OSCAR Gene

  • Protein details for OSCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS5-OSCAR_HUMAN
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Protein Accession:
    Q8IYS5
    Secondary Accessions:
    • B7WNS2
    • Q5GRG5
    • Q8N763
    • Q8NHL4
    • Q8WXQ0
    • Q8WXQ1
    • Q8WXQ2

    Protein attributes for OSCAR Gene

    Size:
    282 amino acids
    Molecular mass:
    30481 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OSCAR Gene

    Alternative splice isoforms for OSCAR Gene

neXtProt entry for OSCAR Gene

Post-translational modifications for OSCAR Gene

No Post-translational modifications

No data available for DME Specific Peptides for OSCAR Gene

Domains & Families for OSCAR Gene

Gene Families for OSCAR Gene

Protein Domains for OSCAR Gene

Suggested Antigen Peptide Sequences for OSCAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYS5

UniProtKB/Swiss-Prot:

OSCAR_HUMAN :
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
genes like me logo Genes that share domains with OSCAR: view

Function for OSCAR Gene

Molecular function for OSCAR Gene

UniProtKB/Swiss-Prot Function:
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
genes like me logo Genes that share phenotypes with OSCAR: view

Animal Models for OSCAR Gene

MGI Knock Outs for OSCAR:

Animal Model Products

  • Taconic Biosciences Mouse Models for OSCAR

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OSCAR Gene

Localization for OSCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSCAR Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSCAR Gene COMPARTMENTS Subcellular localization image for OSCAR gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSCAR: view

Pathways & Interactions for OSCAR Gene

genes like me logo Genes that share pathways with OSCAR: view

Pathways by source for OSCAR Gene

Gene Ontology (GO) - Biological Process for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with OSCAR: view

No data available for SIGNOR curated interactions for OSCAR Gene

Drugs & Compounds for OSCAR Gene

(1) Drugs for OSCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OSCAR: view

Transcripts for OSCAR Gene

Unigene Clusters for OSCAR Gene

Osteoclast associated, immunoglobulin-like receptor:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for OSCAR Gene

GeneLoc Exon Structure for
OSCAR
ECgene alternative splicing isoforms for
OSCAR

Expression for OSCAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSCAR Gene

mRNA differential expression in normal tissues according to GTEx for OSCAR Gene

This gene is overexpressed in Whole Blood (x35.1).

Protein differential expression in normal tissues from HIPED for OSCAR Gene

This gene is overexpressed in Urine (54.4), Serum (7.4), and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSCAR Gene



Protein tissue co-expression partners for OSCAR Gene

NURSA nuclear receptor signaling pathways regulating expression of OSCAR Gene:

OSCAR

SOURCE GeneReport for Unigene cluster for OSCAR Gene:

Hs.347655
genes like me logo Genes that share expression patterns with OSCAR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OSCAR Gene

Orthologs for OSCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSCAR 34 35
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia OSCAR 34 35
  • 84.56 (n)
dog
(Canis familiaris)
Mammalia OSCAR 34 35
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia Oscar 34 16 35
  • 75.2 (n)
rat
(Rattus norvegicus)
Mammalia Oscar 34
  • 73.2 (n)
oppossum
(Monodelphis domestica)
Mammalia OSCAR 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSCAR 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 11 (a)
OneToMany
Species where no ortholog for OSCAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSCAR Gene

ENSEMBL:
Gene Tree for OSCAR (if available)
TreeFam:
Gene Tree for OSCAR (if available)

Paralogs for OSCAR Gene

(1) SIMAP similar genes for OSCAR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSCAR: view

Variants for OSCAR Gene

Sequence variations from dbSNP and Humsavar for OSCAR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1657535 --
rs8106130 --
rs869189131 -- 54,097,612(-) GCCTC(-/AA)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSCAR Gene

Variant ID Type Subtype PubMed ID
dgv3653n100 CNV gain 25217958
esv1149991 CNV insertion 17803354
esv2718812 CNV deletion 23290073
esv3556615 CNV deletion 23714750
esv3893246 CNV gain 25118596
nsv1056177 CNV gain 25217958
nsv182 CNV deletion 15895083
nsv2542 CNV deletion 18451855
nsv470157 CNV loss 18288195
nsv510773 CNV deletion 20534489
nsv833877 CNV loss 17160897
nsv953613 CNV deletion 24416366

Variation tolerance for OSCAR Gene

Gene Damage Index Score: 3.79; 58.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSCAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSCAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSCAR Gene

Disorders for OSCAR Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSCAR Gene - From: DISEASES

Disorder Aliases PubMed IDs
mucinous tubular and spindle renal cell carcinoma
  • mucinous tubular and spindle cell renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search OSCAR in MalaCards View complete list of genes associated with diseases

Relevant External Links for OSCAR

Genetic Association Database (GAD)
OSCAR
Human Genome Epidemiology (HuGE) Navigator
OSCAR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSCAR
genes like me logo Genes that share disorders with OSCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSCAR Gene

Publications for OSCAR Gene

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PMID: 11805147) Kim N. … Choi Y. (J. Exp. Med. 2002) 2 3 4 22 64
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  3. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PMID: 18821671) Herman S. … Schett G. (Arthritis Rheum. 2008) 3 22 64
  4. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PMID: 16007331) Kim G.S. … Shin H.D. (J. Bone Miner. Res. 2005) 3 22 64
  5. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PMID: 16109714) Kim K. … Kim N. (J. Biol. Chem. 2005) 3 22 64

Products for OSCAR Gene

Sources for OSCAR Gene

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