Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSCAR Gene

protein-coding   GIFtS: 53
GCID: GC19M054597

osteoclast associated, immunoglobulin-like receptor

 Explore 7 diseases affiliated with
OSCAR via our new
 Human Malady Compendium 
Biological research products
for OSCAR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Osteoclast Associated, Immunoglobulin-Like Receptor1 2     PIGR32
Osteoclast-Associated Receptor2 3     Osteoclast Associated Receptor OSCAR-S12
Poly-Ig Receptor 32 3     Osteoclast Associated Receptor OSCAR-S22
Polymeric Immunoglobulin Receptor 32 3     Osteoclast-Associated Immunoglobulin-Like Receptor2
PIgR-32 3     PIgR33
HOSCAR1     

External Ids:    HGNC: 299601   Entrez Gene: 1260142   Ensembl: ENSG000001709097   OMIM: 6068625   UniProtKB: Q8IYS53   

Export aliases for OSCAR gene to outside databases

Previous GC identifers: GC19M055243 GC19M055022 GC19M059273 GC19M059289 GC19M050913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSCAR:
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an
osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that
plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC
members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important
bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation
(By similarity)

Gene Wiki entry for OSCAR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSCAR gene promoter:
         NF-1   NF-1/L   AP-1   AML1a   Pax-2   Pax-2a   YY1   PPAR-gamma1   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSCAR promoter sequence
   Search SABiosciences Chromatin IP Primers for OSCAR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSCAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

OSCAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSCAR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054597:  view genomic region     (about GC identifiers)

Start:
54,597,933 bp from pter      End:
54,606,000 bp from pter
Size:
8,068 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5 (See protein sequence)
Recommended Name: Osteoclast-associated immunoglobulin-like receptor precursor  
Size: 282 amino acids; 30481 Da
Subcellular location: Isoform 1: Secreted (Potential)
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B7WNS2 Q5GRG5 Q8N763 Q8NHL4 Q8WXQ0 Q8WXQ1 Q8WXQ2
Alternative splicing: 7 isoforms:  Q8IYS5-1   Q8IYS5-2   Q8IYS5-3   Q8IYS5-4   Q8IYS5-5   Q8IYS5-7   Q8IYS5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSCAR: NX_Q8IYS5

OSCAR Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (4 alternative transcripts): 
NP_570127.2  NP_573398.1  NP_573399.1  NP_996554.1  

ENSEMBL proteins: 
 ENSP00000375641   ENSP00000348927   ENSP00000352671   ENSP00000351145   ENSP00000304523  
 ENSP00000365808   ENSP00000375640  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate (see all 4): OSCAR
OriGene Custom Protein Services for OSCAR 
GenScript Custom Purified and Recombinant Proteins Services for OSCAR
Novus Biologicals OSCAR Protein
Novus Biologicals OSCAR Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for OSCAR

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--


OSCAR for ontologies           About GeneDecksing



OSCAR Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for OSCAR
Browse OriGene Antibodies
OriGene Custom Antibody Services for OSCAR 
GenScript Custom Superior Antibodies Services for OSCAR
Novus Biologicals OSCAR Antibodies
Search for Antibodies for OSCAR at Abcam  
Uscn Antibodies for OSCAR
ThermoFisher Antibodies for OSCAR

Assay Products for OSCAR: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for OSCAR
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for OSCAR


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OSCAR for domains           About GeneDecksing

2 InterPro domains/families:
 IPR013783 Ig-like_fold
 IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q8IYS5

ProtoNet protein and cluster: Q8IYS5

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Similarity: Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation
(By similarity)

miRNA
Products:
    
OriGene 3'-UTR Clone (see all 4): OSCAR
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSCAR
1 QIAGEN miScript miRNA Assays for microRNA that regulate OSCAR:
hsa-miR-1321
SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSCAR (see all 4)
OriGene shRNA RFP: OSCAR
OriGene siRNA: OSCAR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSCAR

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for OSCAR

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 4): OSCAR (NM_130771)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSCAR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for OSCAR
Search LifeMap BioReagents cell lines for OSCAR

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSCAR

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004872receptor activity ----


OSCAR for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Oscartm1Ywc for OSCAR
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oscar):
 cellular  hematopoietic system  immune system  skeleton 

OSCAR for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Osteoclast differentiation
Osteoclast differentiation1.00

Pathway sources
See GeneCards unified pathways
Show all pathways



1         Kegg Pathway  (Kegg details for OSCAR):
    Osteoclast differentiation


OSCAR for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSCAR

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for OSCAR (Q8IYS53 ENSP000003526714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
FCARP240713, ENSP000003477144I2D: score=1 STRING: ENSP00000347714
FCGR2AENSP000002714504STRING: ENSP00000271450
FCGR3AENSP000003569464STRING: ENSP00000356946
FCGR3BENSP000002948004STRING: ENSP00000294800
SYKENSP000003648984STRING: ENSP00000364898
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OSCAR for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OSCAR
1 Novoseek chemical compound relationship for OSCAR gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 0 2 16046394 (1), 16109714 (1)

Search CenterWatch for drugs/clinical trials and news about OSCAR 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OSCAR gene (5 alternative transcripts): 
NM_130771.3  NM_133168.3  NM_133169.3  NM_206818.1  NM_206817.1  

Unigene Cluster for OSCAR:

Osteoclast associated, immunoglobulin-like receptor
Hs.347655  [show with all ESTs]
Unigene Representative Sequence: BC035023
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000391761 ENST00000356532 ENST00000359649 ENST00000358375 ENST00000351806
ENST00000284648(uc002qcy.3 uc002qcz.3 uc002qda.3 uc002qdb.3 uc010erc.3 uc002qdc.3 uc002qdd.3)
ENST00000391760

miRNA
Products:
     
OriGene 3'-UTR Clone (see all 4): OSCAR
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSCAR
1 QIAGEN miScript miRNA Assays for microRNA that regulate OSCAR:
hsa-miR-1321
SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSCAR (see all 4)
OriGene shRNA RFP: OSCAR
OriGene siRNA: OSCAR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSCAR
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 4): OSCAR (NM_130771)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSCAR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSCAR
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSCAR
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSCAR
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSCAR

Additional cDNA sequence: 

AF251702.1 AF391162.1 AF391163.1 AF391164.1 AF474152.1 AF474153.1 AK091111.1 AK130199.1 
AK311307.1 BC035023.2 

7 DOTS entries:

DT.95117024  DT.95160600  DT.97838145  DT.91850607  DT.100021891  DT.97838147  DT.438842 

24/48 AceView cDNA sequences (see all 48):

AF391163 CR613625 AA321203 AF391162 NM_133169 NM_206817 NM_130771 NM_206818 
AF391164 NM_133168 AK091111 BC035023 CB149498 CB112197 CB132199 CB141268 
AK130199 AF251702 BI908482 BI907616 CA306879 CB139698 AX746784 BI523847 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1:                    -     -     -     -                             -                     
SP2:                                -     -                             -                     
SP3:                          -                                                               
SP4:                    -     -     -     -                                                   
SP5:                                -                                                         


ECgene alternative splicing isoforms for OSCAR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OSCAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGGGGACA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See OSCAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSCAR

SOURCE GeneReport for Unigene cluster: Hs.347655
    SABiosciences Custom PCR Arrays for OSCAR
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSCAR
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSCAR
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSCAR
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSCAR
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSCAR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR gene from 2/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
--
(see all 59)
--
27(a)
25(a)
(see all 59)
many ↔ many
many ↔ many
(see all 59)
Un(10797126-10797984)
Un(7502858-7503788)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
--
8(a)
12(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343329.1(1200149-1218701)
GL343329.1(1231914-1234163)


ENSEMBL Gene Tree for OSCAR (if available)
TreeFam Gene Tree for OSCAR (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OSCAR gene
KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  NCR12  
LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  KIR3DL32  
KIR2DL12  A1BG2  LILRB22  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
LILRB32  GP62  
2 SIMAP similar genes for OSCAR using alignment to 2 protein entries:     OSCAR_HUMAN (see all proteins):
LAIR2    LILRA3

OSCAR for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/152 NCBI SNPs in OSCAR are shown (see all 152    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1853752671,2
--54597467(+) CCCGGA/GAGGCG 4 -- ds50010--------
rs1913139071,2
--54597489(+) GAACCA/GAGATC 4 -- ds50010--------
rs6447471,2
C,F,--54597545(-) TCTTTT/CTTTTT 4 -- ds50016Minor allele frequency- C:0.11WA NA EA 364
rs1173597111,2
--54597676(+) ACTACG/AGGCCA 4 -- ds50011Minor allele frequency- A:0.01NA 120
rs789282371,2
F,--54597720(+) ACTGAA/CTCCTA 4 -- ds50011Minor allele frequency- C:0.04NA 120
rs800414351,2
F,--54597853(+) TTGTGG/CTCTCG 4 -- ds50012Minor allele frequency- C:0.08WA EA 238
rs1494889041,2
--54597932(+) AAAGAC/GTTAGC 4 -- ds50010--------
rs1170502891,2
F,--54597965(+) AGCAAG/AAGAAC 4 -- ut311Minor allele frequency- A:0.03NA 120
rs1830183161,2
--54597977(+) AAGCTC/GCCACA 4 -- ut310--------
rs1180275251,2
C,F,--54597983(+) NNNNAG/ACGTGG 4 -- ut311Minor allele frequency- A:0.04NA 120

HapMap Linkage Disequilibrium report for OSCAR (54597933 - 54606000 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for OSCAR
     2 CNVs: 35674 0519

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSCAR
DNA2.0 Custom Variant and Variant Library Synthesis for OSCAR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OSCAR for disorders           About GeneDecksing

OMIM gene information: 606862    OMIM disorders: --

7 diseases for OSCAR:    About MalaCards
decubitus ulcer    microphthalmia    rheumatoid arthritis    down syndrome
hepatitis b    arthritis    hepatitis

1 disease from the University of Copenhagen DISEASES database for OSCAR:
Decubitus ulcer

3 Novoseek disease relationships for OSCAR gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
microphthalmia 63.6 2 16109714 (2)
necrosis 20.9 1 18821671 (1)
tumors 0 1 18821671 (1)

Human Genome Epidemiology (HuGE) Navigator: OSCAR (9 documents)

Export disorders for OSCAR gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OSCAR gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with OSCAR)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PubMed id 11805147)1, 2, 3, 9 Kim N.... Choi Y. (2002)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PubMed id 18821671)1, 9 Herman S....Schett G. (2008)
  4. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PubMed id 16109714)1, 9 Kim K....Kim N. (2005)
  5. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PubMed id 16007331)1, 9 Kim G.S....Shin H.D. (2005)
  6. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. (PubMed id 15155468)1, 9 Merck E....Bates E.E. (2004)
  7. OSCAR is a collagen receptor that costimulates osteoc lastogenesis in DAP12-deficient humans and mice. (PubMed id 21841309)1 Barrow A.D....Trowsdale J. (2011)
  8. The role of osteoclast-associated receptor in osteoim munology. (PubMed id 21172874)1 Nemeth K....Goettsch C. (2011)
  9. The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial ce lls. (PubMed id 22009730)1 Goettsch C....Hofbauer L.C. (2011)
  10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 126014 HGNC: 29960 AceView: OSCAR Ensembl:ENSG00000170909 euGenes: HUgn126014
ECgene: OSCAR Kegg: 126014 H-InvDB: OSCAR

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OSCAR Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OSCAR gene:
Search GeneIP for patents involving OSCAR

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for OSCAR (OSCAR)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for OSCAR  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSCAR   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSCAR  
 OriGene Protein Over-expression Lysate for OSCAR   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for OSCAR   OriGene 3'-UTR Clone for OSCAR  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSCAR  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for OSCAR   OriGene Custom Protein Services for OSCAR  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSCAR
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSCAR
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSCAR
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSCAR
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSCAR
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSCAR
 GenScript Custom Purified and Recombinant Proteins Services for OSCAR GenScript cDNA clones with any tag delivered in your preferred vector for OSCAR
 GenScript Custom Assay Services for OSCAR GenScript Custom Superior Antibodies Services for OSCAR
 GenScript Custom overexpressing Cell Line Services for OSCAR CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in OSCAR promoter
 Search Chromatin IP Primers for OSCAR
 RT2 qPCR Primer Assay in human, mouse, rat OSCAR
 GNC Network for OSCAR
 SABiosciences Custom PCR Arrays for OSCAR
 Search Tocris compounds for OSCAR
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 OSCAR antibodies
 OSCAR proteins
 OSCAR lysates
 Search for Antibodies for OSCAR at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for OSCAR
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 OSCAR Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for OSCAR
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSCAR
 SwitchGear 3'UTR luciferase reporter plasmids for OSCAR
 SwitchGear Promoter luciferase reporter plasmids for OSCAR
 ThermoFisher Antibodies for OSCAR
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      OSCAR gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4