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OSCAR Gene

protein-coding   GIFtS: 55
GCID: GC19M054597

Osteoclast Associated, Immunoglobulin-Like Receptor

  See OSCAR-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Osteoclast Associated, Immunoglobulin-Like Receptor1 2     Osteoclast Associated Receptor OSCAR-S22
Poly-Ig Receptor 32 3     Osteoclast-Associated Immunoglobulin-Like Receptor2
Polymeric Immunoglobulin Receptor 32 3     PIgR33
PIgR-32 3     hOSCAR3
PIGR32     Osteoclast-Associated Receptor3
Osteoclast Associated Receptor OSCAR-S12     

External Ids:    HGNC: 299601   Entrez Gene: 1260142   Ensembl: ENSG000001709097   OMIM: 6068625   UniProtKB: Q8IYS53   

Export aliases for OSCAR gene to outside databases

Previous GC identifers: GC19M055243 GC19M055022 GC19M059273 GC19M059289 GC19M050913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSCAR Gene:
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an
osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that
plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play
a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for OSCAR Gene:
OSCAR (osteoclast associated, immunoglobulin-like receptor) is a protein-coding gene. Diseases associated with OSCAR include decubitus ulcer. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast
differentiation (By similarity)

Gene Wiki entry for OSCAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSCAR gene promoter:
         NF-1   NF-1/L   AP-1   AML1a   Pax-2   Pax-2a   YY1   PPAR-gamma1   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSCAR promoter sequence
   Search Chromatin IP Primers for OSCAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSCAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

OSCAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSCAR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054597:  view genomic region     (about GC identifiers)

Start:
54,597,933 bp from pter      End:
54,606,000 bp from pter
Size:
8,068 bases      Orientation:
minus strand

Selected alternative locations (see all 8):
Chr19-,NW_003571054 69,046-75,261      Chr19-,NW_003571060 69,046-75,261      Chr19-,NW_003571059 69,046-75,261     
Chr19-,NW_003571058 69,046-75,261      Chr19-,NW_003571061 69,046-75,261      Chr19-,NW_003571057 69,046-75,261     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5 (See protein sequence)
Recommended Name: Osteoclast-associated immunoglobulin-like receptor precursor  
Size: 282 amino acids; 30481 Da
Secondary accessions: B7WNS2 Q5GRG5 Q8N763 Q8NHL4 Q8WXQ0 Q8WXQ1 Q8WXQ2
Alternative splicing: 7 isoforms:  Q8IYS5-1   Q8IYS5-2   Q8IYS5-3   Q8IYS5-4   Q8IYS5-5   Q8IYS5-7   Q8IYS5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSCAR: NX_Q8IYS5

Explore proteomics data for OSCAR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48, Asn145

  • See OSCAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001269278.1  NP_001269279.1  NP_570127.3  NP_573398.2  NP_573399.2  NP_996554.2  

    ENSEMBL proteins: 
     ENSP00000375641   ENSP00000348927   ENSP00000352671   ENSP00000351145   ENSP00000304523  
     ENSP00000365808   ENSP00000375640  

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    Cloud-Clone Corp. Proteins for OSCAR

     
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    antibodies-online proteins for OSCAR (4 products) 

     
    antibodies-online peptides for OSCAR

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    antibodies-online antibodies for OSCAR (25 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8IYS5

    ProtoNet protein and cluster: Q8IYS5

    UniProtKB/Swiss-Prot: OSCAR_HUMAN, Q8IYS5
    Similarity: Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with OSCAR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSCAR_HUMAN, Q8IYS5
    Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast
    differentiation (By similarity)

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oscar):

     cellular  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with OSCAR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Oscartm1Ywc for OSCAR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSCAR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSCAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSCAR

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    1 qRT-PCR Assays for microRNA that regulate OSCAR:
    hsa-miR-1321
    SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSCAR

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    GenScript: all cDNA clones in your preferred vector (see all 4): OSCAR (NM_130771)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSCAR_HUMAN, Q8IYS5: Isoform 1: Secreted (Potential)
    OSCAR_HUMAN, Q8IYS5: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OSCAR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OSCAR About    
    See pathways by source

    SuperPathContained pathways About
    1Osteoclast differentiation
    Osteoclast differentiation


    Find genes that share SuperPaths with OSCAR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for OSCAR):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSCAR
    Interactions:

        GeneGlobe Interaction Network for OSCAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for OSCAR (Q8IYS53 ENSP000003526714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCARP240713, ENSP000003477144I2D: score=1 STRING: ENSP00000347714
    FCGR2AENSP000002714504STRING: ENSP00000271450
    FCGR3AENSP000003569464STRING: ENSP00000356946
    FCGR3BENSP000002948004STRING: ENSP00000294800
    SYKENSP000003648984STRING: ENSP00000364898
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSCAR

    1 Novoseek inferred chemical compound relationship for OSCAR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 16046394 (1), 16109714 (1)



    Find genes that share compounds with OSCAR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSCAR gene (7 alternative transcripts): 
    NM_001282349.1  NM_001282350.1  NM_130771.4  NM_133168.4  NM_133169.4  NM_206818.2  NM_206817.1  

    Unigene Cluster for OSCAR:

    Osteoclast associated, immunoglobulin-like receptor
    Hs.347655  [show with all ESTs]
    Unigene Representative Sequence: BC035023
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391761 ENST00000356532 ENST00000359649 ENST00000358375 ENST00000351806
    ENST00000284648(uc002qcy.3 uc002qcz.3 uc002qda.3 uc002qdb.3 uc010erc.3 uc002qdc.3 uc002qdd.3)
    ENST00000391760
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate OSCAR:
    hsa-miR-1321
    SwitchGear 3'UTR luciferase reporter plasmidOSCAR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSCAR
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSCAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSCAR
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSCAR
      QuantiTect SYBR Green Assays in human, mouse, rat OSCAR
      QuantiFast Probe-based Assays in human, mouse, rat OSCAR

    Additional mRNA sequence: 

    AF251702.1 AF391162.1 AF391163.1 AF391164.1 AF474152.1 AF474153.1 AK091111.1 AK130199.1 
    AK311307.1 BC035023.2 

    7 DOTS entries:

    DT.95117024  DT.95160600  DT.97838145  DT.91850607  DT.100021891  DT.97838147  DT.438842 

    Selected AceView cDNA sequences (see all 48):

    AA321203 NM_133168 NM_133169 AF391162 NM_206817 CR613625 AF391164 NM_206818 
    AF391163 NM_130771 BI518709 BI908482 CK430091 CB138806 BI907616 AX746784 
    AF251702 AK091111 CA306426 CB141268 AA974396 CA306879 BM549768 BQ109480 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                    -     -     -     -                             -                     
    SP2:                                -     -                             -                     
    SP3:                          -                                                               
    SP4:                    -     -     -     -                                                   
    SP5:                                -                                                         


    ECgene alternative splicing isoforms for OSCAR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSCAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGGGACA
    OSCAR Expression
    About this image

    OSCAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSCAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.347655
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OSCAR gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oscar1 , 5 osteoclast associated receptor1, 5 75.2(n)1
    73.6(a)1
      7 (2.08 cM)5
    2327901  NM_175632.21  NP_783440.11 
     36098135 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    11(a)
    1 → many
    GL343329.1(1197670-1218701)


    ENSEMBL Gene Tree for OSCAR (if available)
    TreeFam Gene Tree for OSCAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSCAR gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    1 SIMAP similar gene for OSCAR using alignment to 2 protein entries:     OSCAR_HUMAN (see all proteins):
    LAIR2

    Find genes that share paralogs with OSCAR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSCAR (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856983441,2
    --50922072(+) GCAGGC/TTCCGG 4 -- us2k10--------
    rs2542601,2
    C,F,A,H--50922073(-) ACCGGC/AACCTG 4 -- us2k129Minor allele frequency- A:0.10EA NA NS WA CSA EU 2632
    rs2001407491,2
    C--50922075(+) GGTTCC/TGGTGG 4 -- us2k10--------
    rs1853752671,2
    --54597467(+) CCCGGA/GAGGCG 4 -- ds50010--------
    rs1913139071,2
    --54597489(+) GAACCA/GAGATC 4 -- ds50010--------
    rs6447471,2
    C,F--54597545(-) TCTTTT/CTTTTT 4 -- ds50016Minor allele frequency- C:0.11WA NA EA 364
    rs1173597111,2
    F--54597676(+) ACTACG/AGGCCA 4 -- ds50011Minor allele frequency- A:0.01NA 120
    rs789282371,2
    C,F--54597720(+) ACTGAA/CTCCTA 4 -- ds50011Minor allele frequency- C:0.04NA 120
    rs800414351,2
    C,F--54597853(+) TTGTGG/CTCTCG 4 -- ds50012Minor allele frequency- C:0.08WA EA 238
    rs1494889041,2
    --54597932(+) AAAGAC/GTTAGC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for OSCAR (54597933 - 54606000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for OSCAR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718812CNV Deletion23290073
    esv1149991CNV Insertion17803354
    nsv2542CNV Loss18451855
    nsv470157CNV Loss18288195
    nsv510773CNV Loss20534489
    nsv833877CNV Loss17160897
    nsv182CNV Loss15895083
    dgv4001n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606862    OMIM disorders: --

    1 disease for OSCAR:    
    About MalaCards
    decubitus ulcer

    1 disease from the University of Copenhagen DISEASES database for OSCAR:
    Decubitus ulcer

    Find genes that share disorders with OSCAR           About GenesLikeMe

    3 Novoseek inferred disease relationships for OSCAR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microphthalmia 63.6 2 16109714 (2)
    necrosis 20.9 1 18821671 (1)
    tumors 0 1 18821671 (1)

    Genetic Association Database (GAD): OSCAR
    Human Genome Epidemiology (HuGE) Navigator: OSCAR (9 documents)

    Export disorders for OSCAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSCAR gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with OSCAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PubMed id 11805147)1, 2, 3, 9 Kim N.... Choi Y. (J. Exp. Med. 2002)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PubMed id 18821671)1, 9 Herman S....Schett G. (Arthritis Rheum. 2008)
    5. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PubMed id 16109714)1, 9 Kim K....Kim N. (J. Biol. Chem. 2005)
    6. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PubMed id 16007331)1, 9 Kim G.S....Shin H.D. (J. Bone Miner. Res. 2005)
    7. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. (PubMed id 15155468)1, 9 Merck E....Bates E.E. (Blood 2004)
    8. The effect of rotative stress on CAII, FAS, FASL, OSCAR, and TRAP gene expression in osteoclasts. (PubMed id 22949349)1 Qing Hong Z....Li L. (J. Cell. Biochem. 2013)
    9. Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells. (PubMed id 22985931)1 Goettsch C....Kalkhof S. (J. Mol. Cell. Cardiol. 2012)
    10. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (BMC Cancer 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126014 HGNC: 29960 AceView: OSCAR Ensembl:ENSG00000170909 euGenes: HUgn126014
    ECgene: OSCAR Kegg: 126014 H-InvDB: OSCAR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSCAR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OSCAR gene:
    Search GeneIP for patents involving OSCAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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