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Aliases for OSCAR Gene

Aliases for OSCAR Gene

  • Osteoclast Associated, Immunoglobulin-Like Receptor 2 3
  • Polymeric Immunoglobulin Receptor 3 3 4
  • Poly-Ig Receptor 3 3 4
  • PIgR-3 3 4
  • PIGR3 3 4
  • Osteoclast-Associated Immunoglobulin-Like Receptor 3
  • Osteoclast Associated Receptor OSCAR-S1 3
  • Osteoclast Associated Receptor OSCAR-S2 3
  • Osteoclast-Associated Receptor 4
  • HOSCAR 4

External Ids for OSCAR Gene

Summaries for OSCAR Gene

Entrez Gene Summary for OSCAR Gene

  • Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for OSCAR Gene

OSCAR (Osteoclast Associated, Immunoglobulin-Like Receptor) is a Protein Coding gene. Diseases associated with OSCAR include decubitus ulcer. Among its related pathways are Osteoclast differentiation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for OSCAR Gene

  • Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Wiki entry for OSCAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSCAR Gene

Genomics for OSCAR Gene

Genomic Location for OSCAR Gene

Start:
54,094,668 bp from pter
End:
54,102,692 bp from pter
Size:
8,025 bases
Orientation:
Minus strand

Genomic View for OSCAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSCAR Gene

Regulatory Elements for OSCAR Gene

Proteins for OSCAR Gene

  • Protein details for OSCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS5-OSCAR_HUMAN
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Protein Accession:
    Q8IYS5
    Secondary Accessions:
    • B7WNS2
    • Q5GRG5
    • Q8N763
    • Q8NHL4
    • Q8WXQ0
    • Q8WXQ1
    • Q8WXQ2

    Protein attributes for OSCAR Gene

    Size:
    282 amino acids
    Molecular mass:
    30481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSCAR Gene

neXtProt entry for OSCAR Gene

Proteomics data for OSCAR Gene at MOPED

Post-translational modifications for OSCAR Gene

  • Glycosylation at Asn48 and Asn145

No data available for DME Specific Peptides for OSCAR Gene

Domains for OSCAR Gene

Gene Families for OSCAR Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for OSCAR Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

OSCAR_HUMAN
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.:
    • Q8IYS5
Family:
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.:
    • Q8IYS5
genes like me logo Genes that share domains with OSCAR: view

Function for OSCAR Gene

Molecular function for OSCAR Gene

UniProtKB/Swiss-Prot Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Ontology (GO) - Molecular Function for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OSCAR: view
genes like me logo Genes that share phenotypes with OSCAR: view

Animal Models for OSCAR Gene

MGI Knock Outs for OSCAR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OSCAR Gene

Localization for OSCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSCAR Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSCAR Gene COMPARTMENTS Subcellular localization image for OSCAR gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OSCAR: view

Pathways for OSCAR Gene

SuperPathways for OSCAR Gene

Superpath Contained pathways
1 Osteoclast differentiation
genes like me logo Genes that share pathways with OSCAR: view

Pathways by source for OSCAR Gene

1 KEGG pathway for OSCAR Gene

Interacting Proteins for OSCAR Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352671%0d%0a9606.ENSP00000347714%0d%0a
Selected Interacting proteins: ENSP00000352671 Q8IYS5-OSCAR_HUMAN for OSCAR Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OSCAR Gene

None

Compounds for OSCAR Gene

(1) Novoseek inferred chemical compound relationships for OSCAR Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with OSCAR: view

Transcripts for OSCAR Gene

Unigene Clusters for OSCAR Gene

Osteoclast associated, immunoglobulin-like receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for OSCAR Gene

GeneLoc Exon Structure for
OSCAR
ECgene alternative splicing isoforms for
OSCAR

Expression for OSCAR Gene

mRNA expression in normal human tissues for OSCAR Gene

mRNA differential expression in normal tissues according to GTEx for OSCAR Gene

This gene is overexpressed in Whole Blood (35.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OSCAR Gene

SOURCE GeneReport for Unigene cluster for OSCAR Gene Hs.347655

genes like me logo Genes that share expressions with OSCAR: view

Orthologs for OSCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSCAR 36
  • 99.13 (n)
  • 98.88 (a)
OSCAR 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSCAR 36
  • 84.56 (n)
  • 80.15 (a)
OSCAR 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSCAR 36
  • 83.2 (n)
  • 78.8 (a)
OSCAR 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oscar 36
  • 75.2 (n)
  • 73.6 (a)
Oscar 16
Oscar 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSCAR 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSCAR 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oscar 36
  • 73.2 (n)
  • 70 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 11 (a)
OneToMany
Species with no ortholog for OSCAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSCAR Gene

ENSEMBL:
Gene Tree for OSCAR (if available)
TreeFam:
Gene Tree for OSCAR (if available)

Paralogs for OSCAR Gene

Selected SIMAP similar genes for OSCAR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSCAR: view

Variants for OSCAR Gene

Sequence variations from dbSNP and Humsavar for OSCAR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs644747 -- 54,094,280(-) TCTTT(C/T)TTTTT downstream-variant-500B
rs661239 -- 54,097,629(+) TTGCT(C/G)TGTTG intron-variant
rs661676 -- 54,099,882(-) tgagc(C/T)gagat intron-variant
rs662133 -- 54,097,835(+) ggctc(A/G)agcaa intron-variant
rs663569 -- 54,098,213(+) AAACT(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSCAR Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv510773 CNV Loss 20534489
nsv182 CNV Loss 15895083
nsv2542 CNV Loss 18451855
nsv470157 CNV Loss 18288195
dgv4001n71 CNV Loss 21882294
esv1149991 CNV Insertion 17803354

Relevant External Links for OSCAR Gene

HapMap Linkage Disequilibrium report
OSCAR

Disorders for OSCAR Gene

(1) MalaCards Diseases for OSCAR Gene

Search for OSCAR Gene in MalaCards »

(1) University of Copenhagen DISEASES for OSCAR Gene

(3) Novoseek inferred disease relationships for OSCAR Gene

Disease -log(P) Hits PubMed IDs
microphthalmia 63.6 2
necrosis 20.9 1
tumors 0 1

Relevant External Links for OSCAR

Genetic Association Database (GAD)
OSCAR
Human Genome Epidemiology (HuGE) Navigator
OSCAR
genes like me logo Genes that share disorders with OSCAR: view

No data available for UniProtKB/Swiss-Prot for OSCAR Gene

Publications for OSCAR Gene

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PMID: 11805147) Kim N. … Choi Y. (J. Exp. Med. 2002) 2 3 4 23
  2. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. (PMID: 15155468) Merck E. … Bates E.E. (Blood 2004) 3 23
  3. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PMID: 16007331) Kim G.S. … Shin H.D. (J. Bone Miner. Res. 2005) 3 23
  4. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PMID: 16109714) Kim K. … Kim N. (J. Biol. Chem. 2005) 3 23
  5. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PMID: 18821671) Herman S. … Schett G. (Arthritis Rheum. 2008) 3 23

Products for OSCAR Gene

Sources for OSCAR Gene

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