Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSBPL9 Gene

Aliases for OSBPL9 Gene

  • Oxysterol Binding Protein Like 9 2 3 5
  • OSBP-Related Protein 9 3 4
  • ORP-9 3 4
  • ORP9 3 4
  • Oxysterol-Binding Protein-Related Protein 9 3
  • Oxysterol Binding Protein-Like 9 2
  • OSBP4 4

External Ids for OSBPL9 Gene

Previous GeneCards Identifiers for OSBPL9 Gene

  • GC01P051710
  • GC01P050971
  • GC01P051441
  • GC01P051452
  • GC01P051794
  • GC01P051855
  • GC01P052042
  • GC01P050200

Summaries for OSBPL9 Gene

Entrez Gene Summary for OSBPL9 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]

GeneCards Summary for OSBPL9 Gene

OSBPL9 (Oxysterol Binding Protein Like 9) is a Protein Coding gene. Among its related pathways are Metabolism and Synthesis of bile acids and bile salts. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL9 Gene

Additional gene information for OSBPL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL9 Gene

Genomics for OSBPL9 Gene

Regulatory Elements for OSBPL9 Gene

Enhancers for OSBPL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H051670 1.2 Ensembl ENCODE 17 +95.0 94974 2.7 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT FEZF1 ZBTB40 RAD21 GATA2 EGR1 OSBPL9 ENSG00000212624 ENSG00000227070 EPS15 RNU6-877P NRDC GAPDHP51 LOC105378719
GH01H051642 1.4 FANTOM5 Ensembl ENCODE 11.7 +66.6 66622 3.4 PKNOX1 JUN ZNF384 CTBP1 ZNF366 POLR2A ZSCAN5C FOS PRDM10 KLF8 NRDC OSBPL9 ENSG00000212624 RNU6-877P LOC105378719 GAPDHP51
GH01H051688 1.3 Ensembl ENCODE 11.8 +114.0 113967 5.3 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ZNF121 FOS ATF7 SP5 ENSG00000212624 OSBPL9 ZCCHC11 RNU6-877P GAPDHP51 LOC105378719
GH01H051647 1.2 Ensembl ENCODE 10.9 +71.6 71613 3.4 HDGF ATF1 YBX1 FEZF1 TCF12 GLIS2 FOS ATF7 ZNF518A MAFF ZCCHC11 PRPF38A ENSG00000272100 OSBPL9 ENSG00000212624 RNU6-877P NRDC ENSG00000266993 LOC105378719 GAPDHP51
GH01H051768 0.8 ENCODE 14.9 +192.1 192093 1.5 CTCF SAP130 ARNT ZNF384 RAD21 YY1 TEAD3 GATA2 SCRT2 HNF4G OSBPL9 NRDC ENSG00000212624 ENSG00000266993 GC01P051733
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSBPL9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OSBPL9 Gene

Genomic Locations for OSBPL9 Gene
221,249 bases
Plus strand

Genomic View for OSBPL9 Gene

Genes around OSBPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL9 Gene

Proteins for OSBPL9 Gene

  • Protein details for OSBPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 9
    Protein Accession:
    Secondary Accessions:
    • B1AKJ8
    • B3KPQ4
    • D3DQ31
    • Q5TFC0
    • Q6IA67
    • Q86YQ3
    • Q8NB17
    • Q8TAS8
    • Q96SK4
    • Q9H9X2

    Protein attributes for OSBPL9 Gene

    736 amino acids
    Molecular mass:
    83185 Da
    Quaternary structure:
    • Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).
    • Sequence=CAH71119.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL9 Gene

neXtProt entry for OSBPL9 Gene

Post-translational modifications for OSBPL9 Gene

  • Ubiquitination at posLast=670670
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OSBPL9 Gene

Domains & Families for OSBPL9 Gene

Gene Families for OSBPL9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OSBP family.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL9: view

Function for OSBPL9 Gene

Gene Ontology (GO) - Molecular Function for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0015248 sterol transporter activity TAS --
genes like me logo Genes that share ontologies with OSBPL9: view

Phenotypes for OSBPL9 Gene

genes like me logo Genes that share phenotypes with OSBPL9: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL9 Gene

Localization for OSBPL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL9 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSBPL9 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endosome 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0031902 late endosome membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with OSBPL9: view

Pathways & Interactions for OSBPL9 Gene

genes like me logo Genes that share pathways with OSBPL9: view

Gene Ontology (GO) - Biological Process for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006699 bile acid biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0015918 sterol transport IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

No data available for SIGNOR curated interactions for OSBPL9 Gene

Drugs & Compounds for OSBPL9 Gene

No Compound Related Data Available

Transcripts for OSBPL9 Gene

Unigene Clusters for OSBPL9 Gene

Oxysterol binding protein-like 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -

Relevant External Links for OSBPL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSBPL9 Gene

Protein differential expression in normal tissues from HIPED for OSBPL9 Gene

This gene is overexpressed in Breast (24.5), Liver (6.4), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSBPL9 Gene

Protein tissue co-expression partners for OSBPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSBPL9 Gene:


SOURCE GeneReport for Unigene cluster for OSBPL9 Gene:


mRNA Expression by UniProt/SwissProt for OSBPL9 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for OSBPL9 Gene

  • Liver(4.4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with OSBPL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSBPL9 Gene

Orthologs for OSBPL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSBPL9 33 34
  • 99.72 (n)
(Bos Taurus)
Mammalia OSBPL9 33 34
  • 94.06 (n)
(Canis familiaris)
Mammalia OSBPL9 33 34
  • 93.79 (n)
(Mus musculus)
Mammalia Osbpl9 33 16 34
  • 91.79 (n)
(Rattus norvegicus)
Mammalia Osbpl9 33
  • 91.7 (n)
(Monodelphis domestica)
Mammalia OSBPL9 34
  • 91 (a)
(Gallus gallus)
Aves OSBPL9 33 34
  • 81.81 (n)
(Anolis carolinensis)
Reptilia OSBPL9 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl9 33
  • 78.92 (n)
Str.16721 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24000 33
(Danio rerio)
Actinopterygii osbpl9 33 34
  • 73.11 (n)
Dr.10500 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005510 33
  • 59.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1513 35 33 34
  • 54.45 (n)
(Caenorhabditis elegans)
Secernentea obr-4 33 34
  • 52.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH7 34
  • 33 (a)
OSH6 34
  • 30 (a)
HES1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10844 34
  • 53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8972 33
Species where no ortholog for OSBPL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL9 Gene

Gene Tree for OSBPL9 (if available)
Gene Tree for OSBPL9 (if available)

Paralogs for OSBPL9 Gene

Variants for OSBPL9 Gene

Sequence variations from dbSNP and Humsavar for OSBPL9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000024022 -- 51,741,212(+) TTCTA(C/T)AAGTC intron-variant
rs1000029642 -- 51,697,467(+) TTTTT(A/T)TTTTT intron-variant
rs1000056451 -- 51,740,827(+) AGAAC(C/T)TCACC intron-variant
rs1000099704 -- 51,699,082(+) CAATT(G/T)TAAGG intron-variant
rs1000102357 -- 51,664,138(+) TTAAT(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL9 Gene

Variant ID Type Subtype PubMed ID
nsv945941 CNV duplication 23825009
nsv508193 CNV deletion 20534489
nsv1119688 CNV deletion 24896259
esv3586043 CNV loss 21293372
esv3586042 CNV loss 21293372
esv3586041 CNV loss 21293372
esv2676547 CNV deletion 23128226
esv1052378 CNV insertion 17803354
esv1008107 CNV deletion 20482838

Variation tolerance for OSBPL9 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL9 Gene

Disorders for OSBPL9 Gene

Relevant External Links for OSBPL9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSBPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL9 Gene

Publications for OSBPL9 Gene

  1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) Perttilä J … Olkkonen VM (Journal of molecular medicine (Berlin, Germany) 2009) 3 22 45 60
  2. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PMID: 20599956) Zhou Y … Olkkonen VM (Experimental cell research 2010) 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. (PMID: 19129476) Ngo M … Ridgway ND (Molecular biology of the cell 2009) 3 22 60
  5. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. (PMID: 19377067) Chen T … Wang C (Cardiovascular research 2009) 3 22 60

Products for OSBPL9 Gene

Sources for OSBPL9 Gene

Loading form....