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Aliases for OSBPL9 Gene

Aliases for OSBPL9 Gene

  • Oxysterol Binding Protein Like 9 2 3 5
  • OSBP-Related Protein 9 3 4
  • ORP-9 3 4
  • ORP9 3 4
  • Oxysterol-Binding Protein-Related Protein 9 3
  • Oxysterol Binding Protein-Like 9 2
  • OSBP4 4

External Ids for OSBPL9 Gene

Previous GeneCards Identifiers for OSBPL9 Gene

  • GC01P051710
  • GC01P050971
  • GC01P051441
  • GC01P051452
  • GC01P051794
  • GC01P051855
  • GC01P052042
  • GC01P050200

Summaries for OSBPL9 Gene

Entrez Gene Summary for OSBPL9 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]

GeneCards Summary for OSBPL9 Gene

OSBPL9 (Oxysterol Binding Protein Like 9) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL9 Gene

Genomics for OSBPL9 Gene

Regulatory Elements for OSBPL9 Gene

Enhancers for OSBPL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OSBPL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSBPL9 Gene

Chromosome:
1
Start:
51,577,179 bp from pter
End:
51,798,427 bp from pter
Size:
221,249 bases
Orientation:
Plus strand

Genomic View for OSBPL9 Gene

Genes around OSBPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL9 Gene

Proteins for OSBPL9 Gene

  • Protein details for OSBPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SU4-OSBL9_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 9
    Protein Accession:
    Q96SU4
    Secondary Accessions:
    • B1AKJ8
    • B3KPQ4
    • D3DQ31
    • Q5TFC0
    • Q6IA67
    • Q86YQ3
    • Q8NB17
    • Q8TAS8
    • Q96SK4
    • Q9H9X2

    Protein attributes for OSBPL9 Gene

    Size:
    736 amino acids
    Molecular mass:
    83185 Da
    Quaternary structure:
    • Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).
    SequenceCaution:
    • Sequence=CAH71119.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL9 Gene

neXtProt entry for OSBPL9 Gene

Post-translational modifications for OSBPL9 Gene

  • Ubiquitination at Lys 670
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OSBPL9 Gene

Domains & Families for OSBPL9 Gene

Protein Domains for OSBPL9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SU4

UniProtKB/Swiss-Prot:

OSBL9_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL9: view

Function for OSBPL9 Gene

Gene Ontology (GO) - Molecular Function for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

Phenotypes for OSBPL9 Gene

genes like me logo Genes that share phenotypes with OSBPL9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OSBPL9

CRISPR Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL9 Gene

Localization for OSBPL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL9 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL9 Gene COMPARTMENTS Subcellular localization image for OSBPL9 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
endosome 4
nucleus 3

Gene Ontology (GO) - Cellular Components for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

Pathways & Interactions for OSBPL9 Gene

SuperPathways for OSBPL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL9 Gene

Drugs & Compounds for OSBPL9 Gene

No Compound Related Data Available

Transcripts for OSBPL9 Gene

Unigene Clusters for OSBPL9 Gene

Oxysterol binding protein-like 9:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - -
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for OSBPL9 Gene

GeneLoc Exon Structure for
OSBPL9
ECgene alternative splicing isoforms for
OSBPL9

Expression for OSBPL9 Gene

mRNA expression in normal human tissues for OSBPL9 Gene

Protein differential expression in normal tissues from HIPED for OSBPL9 Gene

This gene is overexpressed in Breast (24.5), Liver (6.4), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSBPL9 Gene



Protein tissue co-expression partners for OSBPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSBPL9 Gene:

OSBPL9

SOURCE GeneReport for Unigene cluster for OSBPL9 Gene:

Hs.21938

mRNA Expression by UniProt/SwissProt for OSBPL9 Gene:

Q96SU4-OSBL9_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with OSBPL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OSBPL9 Gene

Orthologs for OSBPL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSBPL9 34
  • 94.06 (n)
  • 97.72 (a)
OSBPL9 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL9 34
  • 93.79 (n)
  • 97.32 (a)
OSBPL9 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl9 34
  • 91.79 (n)
  • 97.51 (a)
Osbpl9 16
Osbpl9 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSBPL9 34
  • 99.72 (n)
  • 100 (a)
OSBPL9 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl9 34
  • 91.7 (n)
  • 97.23 (a)
oppossum
(Monodelphis domestica)
Mammalia OSBPL9 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL9 34
  • 81.81 (n)
  • 88.31 (a)
OSBPL9 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL9 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl9 34
  • 78.92 (n)
  • 87.19 (a)
Str.16721 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24000 34
zebrafish
(Danio rerio)
Actinopterygii Dr.10500 34
osbpl9 34
  • 73.11 (n)
  • 84.17 (a)
osbpl9 35
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1513 36
  • 46 (a)
CG1513 34
  • 54.45 (n)
  • 52.73 (a)
CG1513 35
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005510 34
  • 59.01 (n)
  • 62.87 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-4 34
  • 52.18 (n)
  • 47.22 (a)
obr-4 35
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH6 35
  • 30 (a)
ManyToMany
OSH7 35
  • 33 (a)
ManyToMany
HES1 37
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8972 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10844 35
  • 53 (a)
OneToOne
Species where no ortholog for OSBPL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL9 Gene

ENSEMBL:
Gene Tree for OSBPL9 (if available)
TreeFam:
Gene Tree for OSBPL9 (if available)

Paralogs for OSBPL9 Gene

Paralogs for OSBPL9 Gene

genes like me logo Genes that share paralogs with OSBPL9: view

Variants for OSBPL9 Gene

Sequence variations from dbSNP and Humsavar for OSBPL9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs140080386 - 51,765,840(+) ACCAC(C/T)GAGTA nc-transcript-variant, reference, missense
rs767921 -- 51,759,072(-) CACTG(A/T)GAAAA intron-variant
rs768529 -- 51,769,069(-) ACCCA(A/T)CCTGA intron-variant
rs856599 -- 51,732,526(-) TAGAA(C/T)TTCAT intron-variant
rs856600 -- 51,729,357(+) TGGCA(C/T)GTTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OSBPL9 Gene

Variant ID Type Subtype PubMed ID
esv1008107 CNV deletion 20482838
esv1052378 CNV insertion 17803354
esv2676547 CNV deletion 23128226
esv3586041 CNV loss 21293372
esv3586042 CNV loss 21293372
esv3586043 CNV loss 21293372
nsv1119688 CNV deletion 24896259
nsv508193 CNV deletion 20534489
nsv945941 CNV duplication 23825009

Variation tolerance for OSBPL9 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSBPL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL9 Gene

Disorders for OSBPL9 Gene

Relevant External Links for OSBPL9

Genetic Association Database (GAD)
OSBPL9
Human Genome Epidemiology (HuGE) Navigator
OSBPL9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSBPL9

No disorders were found for OSBPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL9 Gene

Publications for OSBPL9 Gene

  1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) PerttilAo J. … Olkkonen V.M. (J. Mol. Med. 2009) 3 22 46 65
  2. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PMID: 20599956) Zhou Y. … Olkkonen V.M. (Exp. Cell Res. 2010) 3 4 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. (PMID: 19129476) Ngo M. … Ridgway N.D. (Mol. Biol. Cell 2009) 3 22 65
  5. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. (PMID: 19377067) Chen T. … Wang C. (Cardiovasc. Res. 2009) 3 22 65

Products for OSBPL9 Gene

Sources for OSBPL9 Gene

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