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Aliases for OSBPL9 Gene

Aliases for OSBPL9 Gene

  • Oxysterol Binding Protein-Like 9 2 3
  • ORP9 3 4 6
  • OSBP-Related Protein 9 3 4
  • ORP-9 3 4
  • Oxysterol-Binding Protein-Related Protein 9 3
  • OSBP4 4

External Ids for OSBPL9 Gene

Previous GeneCards Identifiers for OSBPL9 Gene

  • GC01P051710
  • GC01P050971
  • GC01P051441
  • GC01P051452
  • GC01P051794
  • GC01P051855
  • GC01P052042
  • GC01P050200

Summaries for OSBPL9 Gene

Entrez Gene Summary for OSBPL9 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]

GeneCards Summary for OSBPL9 Gene

OSBPL9 (Oxysterol Binding Protein-Like 9) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL9 Gene

Genomics for OSBPL9 Gene

Regulatory Elements for OSBPL9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSBPL9 Gene

Start:
51,577,179 bp from pter
End:
51,798,427 bp from pter
Size:
221,249 bases
Orientation:
Plus strand

Genomic View for OSBPL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL9 Gene

Proteins for OSBPL9 Gene

  • Protein details for OSBPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SU4-OSBL9_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 9
    Protein Accession:
    Q96SU4
    Secondary Accessions:
    • B1AKJ8
    • B3KPQ4
    • D3DQ31
    • Q5TFC0
    • Q6IA67
    • Q86YQ3
    • Q8NB17
    • Q8TAS8
    • Q96SK4
    • Q9H9X2

    Protein attributes for OSBPL9 Gene

    Size:
    736 amino acids
    Molecular mass:
    83185 Da
    Quaternary structure:
    • Heterodimer with OSBPL11.
    SequenceCaution:
    • Sequence=CAH71119.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL9 Gene

neXtProt entry for OSBPL9 Gene

Proteomics data for OSBPL9 Gene at MOPED

Post-translational modifications for OSBPL9 Gene

  • Ubiquitination at Lys670
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OSBPL9 Gene

Domains for OSBPL9 Gene

Gene Families for OSBPL9 Gene

HGNC:
  • OSBP :Oxysterol binding proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for OSBPL9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SU4

UniProtKB/Swiss-Prot:

OSBL9_HUMAN :
  • Q96SU4
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL9: view

Function for OSBPL9 Gene

Gene Ontology (GO) - Molecular Function for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

Phenotypes for OSBPL9 Gene

GenomeRNAi human phenotypes for OSBPL9:
genes like me logo Genes that share phenotypes with OSBPL9: view

Animal Model Products

CRISPR Products

miRNA for OSBPL9 Gene

miRTarBase miRNAs that target OSBPL9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL9 Gene

Localization for OSBPL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL9 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL9 Gene COMPARTMENTS Subcellular localization image for OSBPL9 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

Pathways for OSBPL9 Gene

SuperPathways for OSBPL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

No data available for Pathways by source for OSBPL9 Gene

Transcripts for OSBPL9 Gene

Unigene Clusters for OSBPL9 Gene

Oxysterol binding protein-like 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - -
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for OSBPL9 Gene

GeneLoc Exon Structure for
OSBPL9
ECgene alternative splicing isoforms for
OSBPL9

Expression for OSBPL9 Gene

mRNA expression in normal human tissues for OSBPL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL9 Gene

SOURCE GeneReport for Unigene cluster for OSBPL9 Gene Hs.21938

mRNA Expression by UniProt/SwissProt for OSBPL9 Gene

Q96SU4-OSBL9_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with OSBPL9: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OSBPL9 Gene

Orthologs for OSBPL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL9 35
  • 99.72 (n)
  • 100 (a)
OSBPL9 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL9 35
  • 94.06 (n)
  • 97.72 (a)
OSBPL9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL9 35
  • 93.79 (n)
  • 97.32 (a)
OSBPL9 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl9 35
  • 91.79 (n)
  • 97.51 (a)
Osbpl9 16
Osbpl9 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBPL9 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl9 35
  • 91.7 (n)
  • 97.23 (a)
chicken
(Gallus gallus)
Aves OSBPL9 35
  • 81.81 (n)
  • 88.31 (a)
OSBPL9 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL9 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24000 35
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl9 35
  • 78.92 (n)
  • 87.19 (a)
Str.16721 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10500 35
osbpl9 35
  • 73.11 (n)
  • 84.17 (a)
osbpl9 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005510 35
  • 59.01 (n)
  • 62.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1513 35
  • 54.45 (n)
  • 52.73 (a)
CG1513 36
  • 48 (a)
OneToOne
CG1513 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-4 35
  • 52.18 (n)
  • 47.22 (a)
obr-4 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HES1 38
OSH6 36
  • 30 (a)
ManyToMany
OSH7 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8972 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10844 36
  • 53 (a)
OneToOne
Species with no ortholog for OSBPL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL9 Gene

ENSEMBL:
Gene Tree for OSBPL9 (if available)
TreeFam:
Gene Tree for OSBPL9 (if available)

Paralogs for OSBPL9 Gene

Paralogs for OSBPL9 Gene

genes like me logo Genes that share paralogs with OSBPL9: view

Variants for OSBPL9 Gene

Sequence variations from dbSNP and Humsavar for OSBPL9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs767921 -- 51,759,072(-) CACTG(A/T)GAAAA intron-variant
rs768529 -- 51,769,069(-) ACCCA(A/T)CCTGA intron-variant
rs856599 -- 51,732,526(-) TAGAA(C/T)TTCAT intron-variant
rs856600 -- 51,729,357(+) TGGCA(C/T)GTTAG intron-variant, upstream-variant-2KB
rs856602 -- 51,767,357(-) ggagt(A/G)cagca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL9 Gene

Variant ID Type Subtype PubMed ID
esv2676547 CNV Deletion 23128226
esv2748107 CNV Deletion 23290073
esv1052378 CNV Insertion 17803354
nsv508193 CNV Loss 20534489
esv1008107 CNV Deletion 20482838

Relevant External Links for OSBPL9 Gene

HapMap Linkage Disequilibrium report
OSBPL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL9 Gene

Disorders for OSBPL9 Gene

Relevant External Links for OSBPL9

Genetic Association Database (GAD)
OSBPL9
Human Genome Epidemiology (HuGE) Navigator
OSBPL9
genes like me logo Genes that share disorders with OSBPL9: view

No data available for UniProtKB/Swiss-Prot for OSBPL9 Gene

Publications for OSBPL9 Gene

  1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) PerttilAo J. … Olkkonen V.M. (J. Mol. Med. 2009) 3 23 48
  2. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 3 4
  3. VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus. (PMID: 15212954) Wyles J.P. … Ridgway N.D. (Exp. Cell Res. 2004) 3 23
  4. Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. (PMID: 16962287) Lessmann E. … Huber M. (Cell. Signal. 2007) 3 23
  5. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. (PMID: 19129476) Ngo M. … Ridgway N.D. (Mol. Biol. Cell 2009) 3 23

Products for OSBPL9 Gene

Sources for OSBPL9 Gene

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