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OSBPL9 Gene

protein-coding   GIFtS: 57
GCID: GC01P052042

Oxysterol Binding Protein-Like 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxysterol Binding Protein-Like 91 2
ORP92 3 5
ORP-92 3
OSBP-Related Protein 92 3
Oxysterol-Binding Protein-Related Protein 92
OSBP43

External Ids:    HGNC: 163861   Entrez Gene: 1148832   Ensembl: ENSG000001178597   OMIM: 6067375   UniProtKB: Q96SU43   

Export aliases for OSBPL9 gene to outside databases

Previous GC identifers: GC01P051710 GC01P050971 GC01P051441 GC01P051452 GC01P051794 GC01P051855 GC01P050200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSBPL9 Gene:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid
receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal
OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member
functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript
variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified
on chromosomes 3, 11 and 12. (provided by RefSeq, Jul 2010)

GeneCards Summary for OSBPL9 Gene:
OSBPL9 (oxysterol binding protein-like 9) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is OSBPL10.

Gene Wiki entry for OSBPL9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBPL9 gene promoter:
         PPAR-alpha   AREB6   NF-1/L   NF-1   Pax-3   SRY   Nkx6-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OSBPL9 promoter sequence
   Search Chromatin IP Primers for OSBPL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBPL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

OSBPL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P052042:  view genomic region     (about GC identifiers)

Start:
52,042,851 bp from pter      End:
52,254,891 bp from pter
Size:
212,041 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for OSBPL9

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 9  
Size: 736 amino acids; 83185 Da
Subunit: Heterodimer with OSBPL11
Sequence caution: Sequence=CAH71119.1; Type=Erroneous initiation;
Secondary accessions: B1AKJ8 B3KPQ4 D3DQ31 Q5TFC0 Q6IA67 Q86YQ3 Q8NB17 Q8TAS8 Q96SK4 Q9H9X2
Alternative splicing: 7 isoforms:  Q96SU4-1   Q96SU4-2   Q96SU4-3   Q96SU4-4   Q96SU4-5   Q96SU4-6   Q96SU4-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSBPL9: NX_Q96SU4

Explore proteomics data for OSBPL9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys670
  • Modification sites at PhosphoSitePlus

  • See OSBPL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_078862.4  NP_683702.1  NP_683703.1  NP_683704.2  NP_683705.1  NP_683706.3  NP_683707.3  

    ENSEMBL proteins: 
     ENSP00000360779   ENSP00000390113   ENSP00000412733   ENSP00000435264   ENSP00000407168  
     ENSP00000413263   ENSP00000434798   ENSP00000435627   ENSP00000432801   ENSP00000435129  
     ENSP00000433083   ENSP00000354970   ENSP00000431274   ENSP00000435247   ENSP00000435429  
     ENSP00000433279   ENSP00000431980   ENSP00000432409   ENSP00000433291   ENSP00000360775  
     ENSP00000337265   ENSP00000433675   ENSP00000402646  

    OSBPL9 Human Recombinant Protein Products:

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    Novus Biologicals OSBPL9 Protein
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSBPL9

     
    Search eBioscience for Proteins for OSBPL9 

     
    antibodies-online proteins for OSBPL9 (4 products) 

     
    antibodies-online peptides for OSBPL9

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    antibodies-online antibodies for OSBPL9 (16 products) 

    OSBPL9 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q96SU4

    ProtoNet protein and cluster: Q96SU4

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    Find genes that share domains with OSBPL9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with OSBPL9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OSBPL9:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OSBPL9

    miRNA
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    miRTarBase miRNAs that target OSBPL9:
    hsa-mir-125a-5p (MIRT045719), hsa-mir-155-5p (MIRT020828), hsa-mir-296-3p (MIRT038381)

    Block miRNA regulation of human, mouse, rat OSBPL9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL9 (see all 44):
    hsa-miR-3685 hsa-miR-607 hsa-miR-188-5p hsa-miR-200a hsa-miR-507 hsa-miR-141 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL9

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    GenScript: all cDNA clones in your preferred vector (see all 7): OSBPL9 (NM_148906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL9

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSBL9_HUMAN, Q96SU4: Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the
    Golgi-late endosome interface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    golgi apparatus2
    endoplasmic reticulum1
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with OSBPL9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBPL9
    Interactions:

        Search GeneGlobe Interaction Network for OSBPL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OSBPL9 (Q96SU43 ENSP000003372654) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV83, ENSP000003416804I2D: score=2 STRING: ENSP00000341680
    GCH1P307933, ENSP000003788904I2D: score=2 STRING: ENSP00000378890
    HAUS1Q96CS23, ENSP000002820584I2D: score=2 STRING: ENSP00000282058
    HIST1H2BLQ998803, ENSP000003666184I2D: score=2 STRING: ENSP00000366618
    OSBPL11Q9BXB43, ENSP000002962204I2D: score=2 STRING: ENSP00000296220
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with OSBPL9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBPL9 (OSBL9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSBPL9 gene (7 alternative transcripts): 
    NM_024586.5  NM_148904.3  NM_148905.3  NM_148906.2  NM_148907.2  NM_148908.3  NM_148909.3  

    Unigene Cluster for OSBPL9:

    Oxysterol binding protein-like 9
    Hs.21938  [show with all ESTs]
    Unigene Representative Sequence: NM_148909
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000371714 ENST00000435274 ENST00000447887 ENST00000495776 ENST00000428468
    ENST00000453295 ENST00000489990 ENST00000484890 ENST00000534040 ENST00000532975
    ENST00000527631 ENST00000531828 ENST00000361556 ENST00000473207 ENST00000533884
    ENST00000481937 ENST00000526917 ENST00000462759
    miRNA
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    Block miRNA regulation of human, mouse, rat OSBPL9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL9 (see all 44):
    hsa-miR-3685 hsa-miR-607 hsa-miR-188-5p hsa-miR-200a hsa-miR-507 hsa-miR-141 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL9
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): OSBPL9 (NM_148906)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL9
    Primer
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    OriGene qPCR primer pairs and template standards for OSBPL9
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBPL9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL9
      QuantiTect SYBR Green Assays in human, mouse, rat OSBPL9
      QuantiFast Probe-based Assays in human, mouse, rat OSBPL9

    Additional mRNA sequence: 

    AF392445.1 AK022554.1 AK027535.1 AK027707.1 AK056617.1 AK074392.1 AK091703.1 AK124037.1 
    AK128043.1 AK297656.1 AK315167.1 AY178997.1 BC006160.2 BC025978.2 CR457288.1 NR_036662.1 

    Selected DOTS entries (see all 36):

    DT.65287456  DT.100824280  DT.91954345  DT.95273733  DT.100824275  DT.91761458  DT.100824279  DT.102832978 
    DT.100038998  DT.40197460  DT.97846615  DT.100824276  DT.121419389  DT.101961602  DT.121419367  DT.91943868 
    DT.121419342  DT.40109625  DT.99957454  DT.121419487  DT.121419508  DT.95273739  DT.100660334  DT.100824270 

    Selected AceView cDNA sequences (see all 245):

    BQ017735 NM_148907 BX645709 BM800662 AA205154 AK074392 AW024317 AU133143 
    AA476352 CB157384 BG499674 AK027535 BC025978 BX419679 BF725011 AA316203 
    BM467862 AI860380 BU183999 CR457288 AK128043 AA322739 NM_148906 AI357548 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                -     -     -           -                             -                 -                                                   
    SP2:                                -     -     -     -     -                             -                 -                                                   
    SP3:                                            -     -     -                             -                 -                                                   
    SP4:                                                  -     -                             -                 -                                                   
    SP5:                                                  -     -     -                       -                 -                                                   

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:              -                           
    SP2:              -                           
    SP3:              -                           
    SP4:              -                           
    SP5:              -                           


    ECgene alternative splicing isoforms for OSBPL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSBPL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTACCTA
    OSBPL9 Expression
    About this image


    OSBPL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
    OSBPL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBPL9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21938

    UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OSBPL9 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbpl91 , 5 oxysterol binding protein-like 91, 5 91.79(n)1
    97.51(a)1
      4 (50.77 cM)5
    1002731  NM_133885.41  NP_598646.41 
     1090611455 
    chicken
    (Gallus gallus)
    Aves OSBPL91 oxysterol binding protein-like 9 81.81(n)
    88.31(a)
      424634  XM_001234182.3  XP_001234183.2 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL96
    oxysterol binding protein-like 9
    87(a)
    1 ↔ 1
    4(114107811-114201962)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240002 Xenopus laevis transcribed sequence with weak similarity more 78.66(n)    CA973432.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.105002 Transcribed sequence with weak similarity to protein more 77.29(n)    57093207 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15131 , 3 oxysterol binding3
    CG15131
    46(a)3
    54.45(n)1
    52.73(a)1
      46C23
    360281  NM_136690.51  NP_610534.31 
    worm
    (Caenorhabditis elegans)
    Secernentea obr-41 obr-4 52.18(n)
    47.22(a)
      172253  NM_059290.5  NP_491691.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HES1(YOR237W)4 Protein implicated in the regulation of ergosterol more   --   15(781994-783298) 854412  NP_014880.1 


    ENSEMBL Gene Tree for OSBPL9 (if available)
    TreeFam Gene Tree for OSBPL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSBPL9 gene
    OSBPL102  OSBPL52  OSBPL82  OSBPL112  
    7 SIMAP similar genes for OSBPL9 using alignment to 17 protein entries:     OSBL9_HUMAN (see all proteins):
    pp14733    PLEKHA3    OSBPL10    OSBPL11    OSBPL8    DKFZp686C0249
    OSBPL5

    Find genes that share paralogs with OSBPL9           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OSBPL9 (see all 6)
    PGOHUM00000242421 PGOHUM00000242855 PGOHUM00000239503 PGOHUM00000239836 PGOHUM00000238083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSBPL9 (see all 2972)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830605761,2
    --52080697(+) GAGGCC/TGAAGT 5 -- us2k10--------
    rs570045941,2
    C,F--52080826(+) GGCTGC/TGGCAA 5 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1854449861,2
    --52080854(+) GGGAGA/GTGGAG 5 -- us2k10--------
    rs1912345411,2
    --52080866(+) TTGCAA/GTGAGC 5 -- us2k10--------
    rs1475869981,2
    C--52080927(+) TCAAA-/AAAAC 
            
    AAAAC
    5 -- us2k10--------
    rs1826177541,2
    --52080964(+) AAAAAA/CCAGAA 5 -- us2k10--------
    rs2001871791,2
    C--52081026(+) TACTC-/TTCTGC 5 -- us2k10--------
    rs1876714771,2
    --52081062(+) AGTATC/TTCTGC 5 -- us2k10--------
    rs1388357631,2
    C--52081126(+) CTTTC-/TTTTTT 5 -- us2k10--------
    rs1921527071,2
    --52081129(+) TTCTTC/TTTTTG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSBPL9 (52042851 - 52254891 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OSBPL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008107CNV Deletion20482838
    esv2676547CNV Deletion23128226
    esv2748107CNV Deletion23290073
    esv1052378CNV Insertion17803354
    nsv508193CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSBPL9
    DNA2.0 Custom Variant and Variant Library Synthesis for OSBPL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606737    OMIM disorders: --


    Find genes that share disorders with OSBPL9           About GenesLikeMe

    Genetic Association Database (GAD): OSBPL9
    Human Genome Epidemiology (HuGE) Navigator: OSBPL9 (5 documents)

    Export disorders for OSBPL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSBPL9 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with OSBPL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PubMed id 19554302)1, 4, 9 PerttilAo J....Olkkonen V.M. (J. Mol. Med. 2009)
    2. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PubMed id 20599956)1, 2 Zhou Y....Olkkonen V.M. (Exp. Cell Res. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)1, 2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (Genomics 2001)
    7. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. (PubMed id 19129476)1, 9 Ngo M. and Ridgway N.D. (Mol. Biol. Cell 2009)
    8. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. (PubMed id 19377067)1, 9 Chen T....Wang C. (Cardiovasc. Res. 2009)
    9. Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. (PubMed id 16962287)1, 9 Lessmann E....Huber M. (Cell. Signal. 2007)
    10. VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus. (PubMed id 15212954)1, 9 Wyles J.P. and Ridgway N.D. (Exp. Cell Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114883 HGNC: 16386 AceView: OSBPL9 Ensembl:ENSG00000117859 euGenes: HUgn114883
    ECgene: OSBPL9 H-InvDB: OSBPL9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSBPL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSBPL9 gene:
    Search GeneIP for patents involving OSBPL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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