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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSBPL9 Gene

protein-coding   GIFtS: 57
GCID: GC01P052042

Oxysterol Binding Protein-Like 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
Oxysterol Binding Protein-Like 91 2
ORP92 3 5
ORP-92 3
OSBP-Related Protein 92 3
Oxysterol-Binding Protein-Related Protein 92
OSBP43

External Ids:    HGNC: 163861   Entrez Gene: 1148832   Ensembl: ENSG000001178597   OMIM: 6067375   UniProtKB: Q96SU43   
ORGUL members:    fRNAdb10:FR307401      
NONCODE14:n410173      
RNAdb15:EVF19162    

Export aliases for OSBPL9 gene to outside databases

Previous GC identifers: GC01P051710 GC01P050971 GC01P051441 GC01P051452 GC01P051794 GC01P051855 GC01P050200


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSBPL9 Gene:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid
receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal
OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member
functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript
variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified
on chromosomes 3, 11 and 12. (provided by RefSeq, Jul 2010)

GeneCards Summary for OSBPL9 Gene: 
OSBPL9 (oxysterol binding protein-like 9) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with OSBPL9 include familial combined hyperlipidemia. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is OSBPL10.

Gene Wiki entry for OSBPL9 Gene

fRNAdb sequence ontology for OSBPL9:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for OSBPL9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSBPL9 gene promoter:
         PPAR-alpha   AREB6   NF-1/L   NF-1   Pax-3   SRY   Nkx6-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OSBPL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for OSBPL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

OSBPL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P052042:  view genomic region     (about GC identifiers)

Start:
52,042,851 bp from pter      End:
52,254,891 bp from pter
Size:
212,041 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for OSBPL9

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 9  
Size: 736 amino acids; 83185 Da
Sequence caution: Sequence=CAH71119.1; Type=Erroneous initiation;
Secondary accessions: B1AKJ8 B3KPQ4 D3DQ31 Q5TFC0 Q6IA67 Q86YQ3 Q8NB17 Q8TAS8 Q96SK4 Q9H9X2
Alternative splicing: 7 isoforms:  Q96SU4-1   Q96SU4-2   Q96SU4-3   Q96SU4-4   Q96SU4-5   Q96SU4-6   Q96SU4-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSBPL9: NX_Q96SU4

Explore proteomics data for OSBPL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96SU4

  • OSBPL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OSBPL9 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_078862.4  NP_683702.1  NP_683703.1  NP_683704.2  NP_683705.1  NP_683706.3  NP_683707.3  

    ENSEMBL proteins: 
     ENSP00000360779   ENSP00000390113   ENSP00000412733   ENSP00000435264   ENSP00000407168  
     ENSP00000413263   ENSP00000434798   ENSP00000435627   ENSP00000432801   ENSP00000435129  
     ENSP00000433083   ENSP00000354970   ENSP00000431274   ENSP00000435247   ENSP00000435429  
     ENSP00000433279   ENSP00000431980   ENSP00000432409   ENSP00000433291   ENSP00000360775  
     ENSP00000337265   ENSP00000433675   ENSP00000402646  

    Human Recombinant Protein Products for OSBPL9: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSBPL9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0031902late endosome membrane IEA--

    OSBPL9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q96SU4

    ProtoNet protein and cluster: Q96SU4

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    OSBPL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    OSBPL9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OSBPL9:
     Synthetic lethal with Ras 

    Animal Models:
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    hsa-miR-3685 hsa-miR-607 hsa-miR-188-5p hsa-miR-200a hsa-miR-507 hsa-miR-141 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL9 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSBPL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/25 Interacting proteins for OSBPL9 (Q96SU43 ENSP000003372654) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV83, ENSP000003416804I2D: score=2 STRING: ENSP00000341680
    GCH1P307933, ENSP000003788904I2D: score=2 STRING: ENSP00000378890
    HAUS1Q96CS23, ENSP000002820584I2D: score=2 STRING: ENSP00000282058
    HIST1H2BLQ998803, ENSP000003666184I2D: score=2 STRING: ENSP00000366618
    OSBPL11Q9BXB43, ENSP000002962204I2D: score=2 STRING: ENSP00000296220
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    OSBPL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSBPL9 (OSBL9)

    Search CenterWatch for drugs/clinical trials and news about OSBPL9 / OSBL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for OSBPL9 gene (7 alternative transcripts): 
    NM_024586.5  NM_148904.3  NM_148905.3  NM_148906.2  NM_148907.2  NM_148908.3  NM_148909.3  

    Unigene Cluster for OSBPL9:

    Oxysterol binding protein-like 9
    Hs.21938  [show with all ESTs]
    Unigene Representative Sequence: NM_148909
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000371714 ENST00000435274 ENST00000447887 ENST00000495776 ENST00000428468
    ENST00000453295 ENST00000489990 ENST00000484890 ENST00000534040 ENST00000532975
    ENST00000527631 ENST00000531828 ENST00000361556 ENST00000473207 ENST00000533884
    ENST00000481937 ENST00000526917 ENST00000462759
    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBPL9 (see all 44):
    hsa-miR-3685 hsa-miR-607 hsa-miR-188-5p hsa-miR-200a hsa-miR-507 hsa-miR-141 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL9 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF392445.1 AK022554.1 AK027535.1 AK027707.1 AK056617.1 AK074392.1 AK091703.1 AK124037.1 
    AK128043.1 AK297656.1 AK315167.1 AY178997.1 BC006160.2 BC025978.2 CR457288.1 NR_036662.1 

    24/36 DOTS entries (see all 36):

    DT.65287456  DT.100824280  DT.91954345  DT.95273733  DT.100824275  DT.91761458  DT.100824279  DT.102832978 
    DT.100038998  DT.40197460  DT.97846615  DT.100824276  DT.121419389  DT.101961602  DT.121419367  DT.91943868 
    DT.121419342  DT.40109625  DT.99957454  DT.121419487  DT.121419508  DT.95273739  DT.100660334  DT.100824270 

    24/245 AceView cDNA sequences (see all 245):

    CD637518 BM467862 BM456426 AA476352 BQ438888 NM_148906 CR457288 BU183999 
    BU192063 AU133433 AA205154 NM_148905 AA721134 CR607539 AK027535 NM_148908 
    AU130257 BX419679 BF745453 AK074392 BQ017735 AW024317 AW264470 BM788851 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                -     -     -           -                             -                 -                                                   
    SP2:                                -     -     -     -     -                             -                 -                                                   
    SP3:                                            -     -     -                             -                 -                                                   
    SP4:                                                  -     -                             -                 -                                                   
    SP5:                                                  -     -     -                       -                 -                                                   

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:              -                           
    SP2:              -                           
    SP3:              -                           
    SP4:              -                           
    SP5:              -                           


    ECgene alternative splicing isoforms for OSBPL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSBPL9 expression in normal human tissues (normalized intensities)      OSBPL9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTACCTA
    OSBPL9 Expression
    About this image


    OSBPL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, post-menopause ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See OSBPL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSBPL9

    SOURCE GeneReport for Unigene cluster: Hs.21938

    UniProtKB/Swiss-Prot: OSBL9_HUMAN, Q96SU4
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for OSBPL9
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OSBPL9 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbpl91 , 5 oxysterol binding protein-like 91, 5 91.79(n)1
    97.51(a)1
      4 (50.77 cM)5
    1002731  NM_133885.41  NP_598646.41 
     1090611455 
    chicken
    (Gallus gallus)
    Aves OSBPL91 oxysterol binding protein-like 9 83.24(n)
    90.05(a)
      424634  XM_422468.3  XP_422468.2 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL96
    oxysterol binding protein-like 9
    87(a)
    1 ↔ 1
    4(114107811-114201962)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240002 Xenopus laevis transcribed sequence with weak similarity more 78.66(n)    CA973432.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.105002 Transcribed sequence with weak similarity to protein more 77.29(n)    57093207 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15131 , 3 oxysterol binding3
    CG15131
    46(a)3
    55.8(n)1
    54.49(a)1
      46C23
    360281  NM_136690.41  NP_610534.31 
    worm
    (Caenorhabditis elegans)
    Secernentea obr-41 Protein OBR-4 52.66(n)
    47.34(a)
      172253  NM_059290.4  NP_491691.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HES1(YOR237W)4 Protein implicated in the regulation of ergosterol more   --   15(781994-783298) 854412  NP_014880.1 


    ENSEMBL Gene Tree for OSBPL9 (if available)
    TreeFam Gene Tree for OSBPL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OSBPL9 gene
    OSBPL102  OSBPL52  OSBPL82  OSBPL112  
    7 SIMAP similar genes for OSBPL9 using alignment to 17 protein entries:     OSBL9_HUMAN (see all proteins):
    pp14733    PLEKHA3    OSBPL10    OSBPL11    OSBPL8    DKFZp686C0249
    OSBPL5

    OSBPL9 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for OSBPL9 (see all 6)
    PGOHUM00000242421 PGOHUM00000242855 PGOHUM00000239503 PGOHUM00000239836 PGOHUM00000238083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2972 SNPs in OSBPL9 are shown (see all 2972)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693804
    ----see VAR_0693802 P L mis40--------
    rs1830605761,2
    --52080697(+) GAGGCC/TGAAGT 5 -- us2k10--------
    rs570045941,2
    C,F--52080826(+) GGCTGC/TGGCAA 5 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1854449861,2
    --52080854(+) GGGAGA/GTGGAG 5 -- us2k10--------
    rs1912345411,2
    --52080866(+) TTGCAA/GTGAGC 5 -- us2k10--------
    rs1475869981,2
    C--52080927(+) TCAAA-/AAAAC 
            
    AAAAC
    5 -- us2k10--------
    rs1826177541,2
    --52080964(+) AAAAAA/CCAGAA 5 -- us2k10--------
    rs2001871791,2
    C--52081026(+) TACTC-/TTCTGC 5 -- us2k10--------
    rs1876714771,2
    --52081062(+) AGTATC/TTCTGC 5 -- us2k10--------
    rs1388357631,2
    C--52081126(+) CTTTC-/TTTTTT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSBPL9 (52042851 - 52254891 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OSBPL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1008107CNV Deletion20482838
    esv2676547CNV Deletion23128226
    esv2748107CNV Deletion23290073
    esv1052378CNV Insertion17803354
    nsv508193CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606737OMIM information: 112265    
    2 diseases for OSBPL9:    About MalaCards
    familial combined hyperlipidemia    


    OSBPL9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSBPL9
    Human Genome Epidemiology (HuGE) Navigator: OSBPL9 (5 documents)

    Export disorders for OSBPL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSBPL9 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with OSBPL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PubMed id 19554302)1, 4, 9 PerttilAo J....Olkkonen V.M. (2009)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)1, 2 Gauci S....Mohammed S. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (2001)
    6. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. (PubMed id 19129476)1, 9 Ngo M. and Ridgway N.D. (2009)
    7. MicroRNA-125a-5p partly regulates the inflammatory re sponse, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macropha ges. (PubMed id 19377067)1, 9 Chen T....Wang C. (2009)
    8. Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. (PubMed id 16962287)1, 9 Lessmann E....Huber M. (2007)
    9. VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus. (PubMed id 15212954)1, 9 Wyles J.P. and Ridgway N.D. (2004)
    10. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114883 HGNC: 16386 AceView: OSBPL9 Ensembl:ENSG00000117859 euGenes: HUgn114883
    ECgene: OSBPL9 H-InvDB: OSBPL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSBPL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSBPL9 gene:
    Search GeneIP for patents involving OSBPL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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