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Aliases for OSBPL9 Gene

Aliases for OSBPL9 Gene

  • Oxysterol Binding Protein Like 9 2 3 5
  • OSBP-Related Protein 9 3 4
  • ORP-9 3 4
  • ORP9 3 4
  • Oxysterol-Binding Protein-Related Protein 9 3
  • Oxysterol Binding Protein-Like 9 2
  • OSBP4 4

External Ids for OSBPL9 Gene

Previous GeneCards Identifiers for OSBPL9 Gene

  • GC01P051710
  • GC01P050971
  • GC01P051441
  • GC01P051452
  • GC01P051794
  • GC01P051855
  • GC01P052042
  • GC01P050200

Summaries for OSBPL9 Gene

Entrez Gene Summary for OSBPL9 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]

GeneCards Summary for OSBPL9 Gene

OSBPL9 (Oxysterol Binding Protein Like 9) is a Protein Coding gene. Among its related pathways are Metabolism and Synthesis of bile acids and bile salts. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL9 Gene

Additional gene information for OSBPL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL9 Gene

Genomics for OSBPL9 Gene

GeneHancer (GH) Regulatory Elements for OSBPL9 Gene

Promoters and enhancers for OSBPL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I051728 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 554 +152.7 152727 3.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B CBX5 OSBPL9 GC01P051732 GC01P051733 ENSG00000266993 PRPF38A TXNDC12 ZCCHC11 NRDC GPX7 KTI12
GH01I051616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.3 +40.3 40258 1.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 OSBPL9 NRDC LOC105378719 CALR4P
GH01I051575 Enhancer 0.8 Ensembl 550.8 -1.4 -1379 0.4 MZF1 EBF1 BATF ZEB1 ZNF664 ZNF366 ZSCAN5C ZNF600 KLF8 KLF13 OSBPL9 CALR4P GC01P051545 LOC105378720
GH01I051577 Promoter 0.7 EPDnew 550.8 0.0 -29 0.1 USF1 MAX OSBPL9 CALR4P GC01P051545 LOC105378720
GH01I051578 Enhancer 0.6 Ensembl 550.8 +1.5 1505 0.6 PKNOX1 FOXA2 NR2F1 TEAD2 ELF1 DPF2 FOXA1 JUND GATA3 HMBOX1 OSBPL9 EPS15 ENSG00000227070 RNU6-877P CALR4P GC01P051592 LOC105378720
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OSBPL9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OSBPL9 gene promoter:

Genomic Locations for OSBPL9 Gene

Genomic Locations for OSBPL9 Gene
chr1:51,577,179-51,798,427
(GRCh38/hg38)
Size:
221,249 bases
Orientation:
Plus strand
chr1:52,042,851-52,254,891
(GRCh37/hg19)

Genomic View for OSBPL9 Gene

Genes around OSBPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL9 Gene

Proteins for OSBPL9 Gene

  • Protein details for OSBPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SU4-OSBL9_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 9
    Protein Accession:
    Q96SU4
    Secondary Accessions:
    • B1AKJ8
    • B3KPQ4
    • D3DQ31
    • Q5TFC0
    • Q6IA67
    • Q86YQ3
    • Q8NB17
    • Q8TAS8
    • Q96SK4
    • Q9H9X2

    Protein attributes for OSBPL9 Gene

    Size:
    736 amino acids
    Molecular mass:
    83185 Da
    Quaternary structure:
    • Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).
    SequenceCaution:
    • Sequence=CAH71119.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL9 Gene

neXtProt entry for OSBPL9 Gene

Post-translational modifications for OSBPL9 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6, 7670

No data available for DME Specific Peptides for OSBPL9 Gene

Domains & Families for OSBPL9 Gene

Gene Families for OSBPL9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SU4

UniProtKB/Swiss-Prot:

OSBL9_HUMAN :
  • Belongs to the OSBP family.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL9: view

Function for OSBPL9 Gene

Gene Ontology (GO) - Molecular Function for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0015248 sterol transporter activity TAS --
genes like me logo Genes that share ontologies with OSBPL9: view

Phenotypes for OSBPL9 Gene

genes like me logo Genes that share phenotypes with OSBPL9: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL9 Gene

Localization for OSBPL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL9 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSBPL9 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endosome 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0031902 late endosome membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with OSBPL9: view

Pathways & Interactions for OSBPL9 Gene

genes like me logo Genes that share pathways with OSBPL9: view

Gene Ontology (GO) - Biological Process for OSBPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006699 bile acid biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0015918 sterol transport IEA --
genes like me logo Genes that share ontologies with OSBPL9: view

No data available for SIGNOR curated interactions for OSBPL9 Gene

Drugs & Compounds for OSBPL9 Gene

No Compound Related Data Available

Transcripts for OSBPL9 Gene

Unigene Clusters for OSBPL9 Gene

Oxysterol binding protein-like 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - -
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for OSBPL9 Gene

GeneLoc Exon Structure for
OSBPL9
ECgene alternative splicing isoforms for
OSBPL9

Expression for OSBPL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSBPL9 Gene

Protein differential expression in normal tissues from HIPED for OSBPL9 Gene

This gene is overexpressed in Breast (24.5), Liver (6.4), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSBPL9 Gene



Protein tissue co-expression partners for OSBPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSBPL9 Gene:

OSBPL9

SOURCE GeneReport for Unigene cluster for OSBPL9 Gene:

Hs.21938

mRNA Expression by UniProt/SwissProt for OSBPL9 Gene:

Q96SU4-OSBL9_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for OSBPL9 Gene

  • Liver(4.4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with OSBPL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSBPL9 Gene

Orthologs for OSBPL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL9 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia OSBPL9 33 34
  • 94.06 (n)
dog
(Canis familiaris)
Mammalia OSBPL9 33 34
  • 93.79 (n)
mouse
(Mus musculus)
Mammalia Osbpl9 33 16 34
  • 91.79 (n)
rat
(Rattus norvegicus)
Mammalia Osbpl9 33
  • 91.7 (n)
oppossum
(Monodelphis domestica)
Mammalia OSBPL9 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL9 33 34
  • 81.81 (n)
lizard
(Anolis carolinensis)
Reptilia OSBPL9 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl9 33
  • 78.92 (n)
Str.16721 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24000 33
zebrafish
(Danio rerio)
Actinopterygii osbpl9 33 34
  • 73.11 (n)
Dr.10500 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005510 33
  • 59.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1513 35 33 34
  • 54.45 (n)
worm
(Caenorhabditis elegans)
Secernentea obr-4 33 34
  • 52.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH7 34
  • 33 (a)
ManyToMany
OSH6 34
  • 30 (a)
ManyToMany
HES1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10844 34
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8972 33
Species where no ortholog for OSBPL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL9 Gene

ENSEMBL:
Gene Tree for OSBPL9 (if available)
TreeFam:
Gene Tree for OSBPL9 (if available)

Paralogs for OSBPL9 Gene

Variants for OSBPL9 Gene

Sequence variations from dbSNP and Humsavar for OSBPL9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024022 -- 51,741,212(+) C/T intron_variant
rs1000029642 -- 51,697,467(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000056451 -- 51,740,827(+) T/C intron_variant
rs1000099704 -- 51,699,082(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000102357 -- 51,664,138(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL9 Gene

Variant ID Type Subtype PubMed ID
esv1008107 CNV deletion 20482838
esv1052378 CNV insertion 17803354
esv2676547 CNV deletion 23128226
esv3586041 CNV loss 21293372
esv3586042 CNV loss 21293372
esv3586043 CNV loss 21293372
nsv1119688 CNV deletion 24896259
nsv508193 CNV deletion 20534489
nsv945941 CNV duplication 23825009

Variation tolerance for OSBPL9 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSBPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSBPL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL9 Gene

Disorders for OSBPL9 Gene

Additional Disease Information for OSBPL9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OSBPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL9 Gene

Publications for OSBPL9 Gene

  1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) Perttilä J … Olkkonen VM (Journal of molecular medicine (Berlin, Germany) 2009) 3 22 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PMID: 20599956) Zhou Y … Olkkonen VM (Experimental cell research 2010) 3 4 58
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 3 4 58
  5. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. (PMID: 19377067) Chen T … Wang C (Cardiovascular research 2009) 3 22 58

Products for OSBPL9 Gene

Sources for OSBPL9 Gene

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