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Aliases for OSBPL8 Gene

Aliases for OSBPL8 Gene

  • Oxysterol Binding Protein-Like 8 2 3
  • ORP8 3 4 6
  • OSBP-Related Protein 8 3 4
  • KIAA1451 4 6
  • OSBP10 3 4
  • ORP-8 3 4
  • Oxysterol-Binding Protein-Related Protein 8 3
  • MSTP120 3
  • MST120 3

External Ids for OSBPL8 Gene

Previous GeneCards Identifiers for OSBPL8 Gene

  • GC12M076333
  • GC12M077087
  • GC12M076678
  • GC12M075248
  • GC12M075269
  • GC12M076745
  • GC12M073797

Summaries for OSBPL8 Gene

Entrez Gene Summary for OSBPL8 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL8 Gene

OSBPL8 (Oxysterol Binding Protein-Like 8) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL8 Gene

Genomics for OSBPL8 Gene

Regulatory Elements for OSBPL8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSBPL8 Gene

76,351,797 bp from pter
76,559,809 bp from pter
208,013 bases
Minus strand

Genomic View for OSBPL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL8 Gene

Proteins for OSBPL8 Gene

  • Protein details for OSBPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 8
    Protein Accession:
    Secondary Accessions:
    • A8K1T2
    • E9PE66
    • E9PE68
    • Q52LQ3
    • Q68D75
    • Q8WXP8
    • Q9P277

    Protein attributes for OSBPL8 Gene

    889 amino acids
    Molecular mass:
    101196 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG53411.1; Type=Frameshift; Positions=30; Evidence={ECO:0000305}; Sequence=BAA95975.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OSBPL8 Gene

    Alternative splice isoforms for OSBPL8 Gene


neXtProt entry for OSBPL8 Gene

Proteomics data for OSBPL8 Gene at MOPED

Post-translational modifications for OSBPL8 Gene

  • Ubiquitination at Lys697
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for OSBPL8 Gene

Domains for OSBPL8 Gene

Gene Families for OSBPL8 Gene

  • OSBP :Oxysterol binding proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for OSBPL8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BZF1
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL8: view

Function for OSBPL8 Gene

Gene Ontology (GO) - Molecular Function for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL8: view

Phenotypes for OSBPL8 Gene

MGI mutant phenotypes for OSBPL8:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OSBPL8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL8 Gene

Localization for OSBPL8 Gene

Subcellular locations from

Jensen Localization Image for OSBPL8 Gene COMPARTMENTS Subcellular localization image for OSBPL8 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with OSBPL8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSBPL8 Gene

Pathways for OSBPL8 Gene

SuperPathways for OSBPL8 Gene

No Data Available

Interacting Proteins for OSBPL8 Gene

Gene Ontology (GO) - Biological Process for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0010891 negative regulation of sequestering of triglyceride IDA 23028956
GO:0030336 negative regulation of cell migration IEA --
GO:0045444 fat cell differentiation IDA 23028956
GO:0046628 positive regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with OSBPL8: view

No data available for Pathways by source for OSBPL8 Gene

Transcripts for OSBPL8 Gene

Unigene Clusters for OSBPL8 Gene

Oxysterol binding protein-like 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP3: -
SP4: -
SP5: - -
SP9: - -
SP10: - - - - - - - -
SP11: -
SP12: - - -
SP13: - - - - - - -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: -

Relevant External Links for OSBPL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL8 Gene

mRNA expression in normal human tissues for OSBPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for OSBPL8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL8 Gene

SOURCE GeneReport for Unigene cluster for OSBPL8 Gene Hs.430849

mRNA Expression by UniProt/SwissProt for OSBPL8 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with OSBPL8: view

Expression partners for OSBPL8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OSBPL8 Gene

Orthologs for OSBPL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSBPL8 35
  • 94.15 (n)
  • 96.96 (a)
  • 97 (a)
(Canis familiaris)
Mammalia OSBPL8 35
  • 95.01 (n)
  • 97.86 (a)
  • 98 (a)
(Mus musculus)
Mammalia Osbpl8 35
  • 89.35 (n)
  • 96.06 (a)
Osbpl8 16
Osbpl8 36
  • 96 (a)
(Pan troglodytes)
Mammalia OSBPL8 35
  • 99.85 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Osbpl8 35
  • 89.64 (n)
  • 96.28 (a)
(Monodelphis domestica)
Mammalia OSBPL8 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia OSBPL8 36
  • 86 (a)
(Gallus gallus)
Aves OSBPL8 35
  • 79.29 (n)
  • 84.55 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia OSBPL8 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl8 35
  • 76.79 (n)
  • 83.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23528 35
(Danio rerio)
Actinopterygii CABZ01007893.1 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5077 37
  • 49 (a)
CG42668 35
  • 57.36 (n)
  • 57.98 (a)
CG42668 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003484 35
  • 57.35 (n)
  • 62.56 (a)
(Caenorhabditis elegans)
Secernentea obr-3 35
  • 55.29 (n)
  • 52 (a)
obr-3 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL287C 35
  • 47.36 (n)
  • 37.31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02827g 35
  • 47.76 (n)
  • 38.01 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH7 35
  • 49.74 (n)
  • 39.32 (a)
OSH6 36
  • 30 (a)
OSH7 36
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9663 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03258 35
  • 44.44 (n)
  • 38.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC23B6.01c 35
  • 49.05 (n)
  • 41.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for OSBPL8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL8 Gene

Gene Tree for OSBPL8 (if available)
Gene Tree for OSBPL8 (if available)

Paralogs for OSBPL8 Gene

Paralogs for OSBPL8 Gene

genes like me logo Genes that share paralogs with OSBPL8: view

Variants for OSBPL8 Gene

Sequence variations from dbSNP and Humsavar for OSBPL8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs875718 -- 76,533,367(-) GGCAC(A/C)TTGAG intron-variant
rs1009478 -- 76,530,604(+) CACAT(A/G)TAAGT intron-variant
rs1039999 -- 76,547,796(+) ACAGT(C/T)TCATT intron-variant
rs1040000 -- 76,548,133(+) TCCCT(C/T)CAGTT intron-variant
rs1040001 -- 76,548,228(+) GAAAA(C/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL8 Gene

Variant ID Type Subtype PubMed ID
nsv520195 CNV Gain 19592680
esv23723 CNV Gain 19812545
esv2746089 CNV Deletion 23290073
esv274660 CNV Insertion 20981092
esv269262 CNV Insertion 20981092
esv2663126 CNV Deletion 23128226

Relevant External Links for OSBPL8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL8 Gene

Disorders for OSBPL8 Gene

Relevant External Links for OSBPL8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for OSBPL8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OSBPL8 Gene

Publications for OSBPL8 Gene

  1. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. (PMID: 17991739) Yan D. … Olkkonen V.M. (J. Biol. Chem. 2008) 2 3 23
  2. Longitudinal growth and growth-plate activity in the lower extremity. (PMID: 1735225) Pritchett J.W. (Clin. Orthop. Relat. Res. 1992) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 3 4
  5. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 3 4

Products for OSBPL8 Gene

Sources for OSBPL8 Gene

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