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Aliases for OSBPL8 Gene

Aliases for OSBPL8 Gene

  • Oxysterol Binding Protein-Like 8 2 3
  • ORP8 3 4 6
  • OSBP-Related Protein 8 3 4
  • KIAA1451 4 6
  • OSBP10 3 4
  • ORP-8 3 4
  • Oxysterol-Binding Protein-Related Protein 8 3
  • MSTP120 3
  • MST120 3

External Ids for OSBPL8 Gene

Summaries for OSBPL8 Gene

Entrez Gene Summary for OSBPL8 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL8 Gene

OSBPL8 (Oxysterol Binding Protein-Like 8) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBPL11.

Gene Wiki entry for OSBPL8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL8 Gene

Genomics for OSBPL8 Gene

Genomic Location for OSBPL8 Gene

Start:
76,351,797 bp from pter
End:
76,559,809 bp from pter
Size:
208,013 bases
Orientation:
Minus strand

Genomic View for OSBPL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL8 Gene

Regulatory Elements for OSBPL8 Gene

Proteins for OSBPL8 Gene

  • Protein details for OSBPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZF1-OSBL8_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 8
    Protein Accession:
    Q9BZF1
    Secondary Accessions:
    • A8K1T2
    • E9PE66
    • E9PE68
    • Q52LQ3
    • Q68D75
    • Q8WXP8
    • Q9P277

    Protein attributes for OSBPL8 Gene

    Size:
    889 amino acids
    Molecular mass:
    101196 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG53411.1; Type=Frameshift; Positions=30; Evidence={ECO:0000305}; Sequence=BAA95975.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OSBPL8 Gene

    Alternative splice isoforms for OSBPL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL8 Gene

Proteomics data for OSBPL8 Gene at MOPED

Post-translational modifications for OSBPL8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys697

No data available for DME Specific Peptides for OSBPL8 Gene

Domains for OSBPL8 Gene

Gene Families for OSBPL8 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBPL8 Gene

UniProtKB/Swiss-Prot:

OSBL8_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9BZF1
Family:
  • Belongs to the OSBP family.:
    • Q9BZF1
genes like me logo Genes that share domains with OSBPL8: view

Function for OSBPL8 Gene

Gene Ontology (GO) - Molecular Function for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL8: view

Phenotypes for OSBPL8 Gene

MGI mutant phenotypes for OSBPL8:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OSBPL8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL8 Gene

Localization for OSBPL8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL8 Gene COMPARTMENTS Subcellular localization image for OSBPL8 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with OSBPL8: view

Pathways for OSBPL8 Gene

SuperPathways for OSBPL8 Gene

No Data Available

Interacting Proteins for OSBPL8 Gene

Gene Ontology (GO) - Biological Process for OSBPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0010891 negative regulation of sequestering of triglyceride IDA 23028956
GO:0030336 negative regulation of cell migration IEA --
GO:0045444 fat cell differentiation IDA 23028956
GO:0046628 positive regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with OSBPL8: view

No data available for Pathways by source for OSBPL8 Gene

Transcripts for OSBPL8 Gene

Unigene Clusters for OSBPL8 Gene

Oxysterol binding protein-like 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -
SP6:
SP7:
SP8:
SP9: - -
SP10: - - - - - - - -
SP11: -
SP12: - - -
SP13: - - - - - - -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for OSBPL8 Gene

GeneLoc Exon Structure for
OSBPL8
ECgene alternative splicing isoforms for
OSBPL8

Expression for OSBPL8 Gene

mRNA expression in normal human tissues for OSBPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL8 Gene

SOURCE GeneReport for Unigene cluster for OSBPL8 Gene Hs.430849

mRNA Expression by UniProt/SwissProt for OSBPL8 Gene

Q9BZF1-OSBL8_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with OSBPL8: view

Orthologs for OSBPL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL8 36
  • 99.85 (n)
  • 100 (a)
OSBPL8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL8 36
  • 94.15 (n)
  • 96.96 (a)
OSBPL8 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL8 36
  • 95.01 (n)
  • 97.86 (a)
OSBPL8 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl8 36
  • 89.35 (n)
  • 96.06 (a)
Osbpl8 16
Osbpl8 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBPL8 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL8 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl8 36
  • 89.64 (n)
  • 96.28 (a)
chicken
(Gallus gallus)
Aves OSBPL8 36
  • 79.29 (n)
  • 84.55 (a)
OSBPL8 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL8 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23528 36
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl8 36
  • 76.79 (n)
  • 83.11 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01007893.1 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003484 36
  • 57.35 (n)
  • 62.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42668 36
  • 57.36 (n)
  • 57.98 (a)
CG42668 37
  • 41 (a)
OneToMany
CG5077 38
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-3 36
  • 55.29 (n)
  • 52 (a)
obr-3 37
  • 46 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL287C 36
  • 47.36 (n)
  • 37.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH6 37
  • 30 (a)
ManyToMany
OSH7 36
  • 49.74 (n)
  • 39.32 (a)
OSH7 37
  • 32 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02827g 36
  • 47.76 (n)
  • 38.01 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03258 36
  • 44.44 (n)
  • 38.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC23B6.01c 36
  • 49.05 (n)
  • 41.14 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9663 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for OSBPL8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL8 Gene

ENSEMBL:
Gene Tree for OSBPL8 (if available)
TreeFam:
Gene Tree for OSBPL8 (if available)

Paralogs for OSBPL8 Gene

Paralogs for OSBPL8 Gene

genes like me logo Genes that share paralogs with OSBPL8: view

Variants for OSBPL8 Gene

Sequence variations from dbSNP and Humsavar for OSBPL8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs875718 -- 76,533,367(-) GGCAC(A/C)TTGAG intron-variant
rs1009478 -- 76,530,604(+) CACAT(A/G)TAAGT intron-variant
rs1039999 -- 76,547,796(+) ACAGT(C/T)TCATT intron-variant
rs1040000 -- 76,548,133(+) TCCCT(C/T)CAGTT intron-variant
rs1040001 -- 76,548,228(+) GAAAA(C/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL8 Gene

Variant ID Type Subtype PubMed ID
nsv520195 CNV Gain 19592680
esv23723 CNV Gain 19812545
esv2746089 CNV Deletion 23290073
esv274660 CNV Insertion 20981092
esv269262 CNV Insertion 20981092
esv2663126 CNV Deletion 23128226

Relevant External Links for OSBPL8 Gene

HapMap Linkage Disequilibrium report
OSBPL8

Disorders for OSBPL8 Gene

Relevant External Links for OSBPL8

Genetic Association Database (GAD)
OSBPL8
Human Genome Epidemiology (HuGE) Navigator
OSBPL8
genes like me logo Genes that share disorders with OSBPL8: view

No data available for UniProtKB/Swiss-Prot for OSBPL8 Gene

Publications for OSBPL8 Gene

  1. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. (PMID: 17991739) Yan D. … Olkkonen V.M. (J. Biol. Chem. 2008) 2 3 23
  2. Longitudinal growth and growth-plate activity in the lower extremity. (PMID: 1735225) Pritchett J.W. (Clin. Orthop. Relat. Res. 1992) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 3 4
  5. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 3 4

Products for OSBPL8 Gene

Sources for OSBPL8 Gene

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