Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OSBPL8 Gene

protein-coding   GIFtS: 56
GCID: GC12M076745

Oxysterol Binding Protein-Like 8

  Search for OSBPL8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Oxysterol Binding Protein-Like 81 2     KIAA14513 5
ORP82 3 5     MST1202
ORP-82 3     MSTP1202
OSBP102 3     Oxysterol-Binding Protein-Related Protein 82
OSBP-Related Protein 82 3     

External Ids:    HGNC: 163961   Entrez Gene: 1148822   Ensembl: ENSG000000910397   OMIM: 6067365   UniProtKB: Q9BZF13   

Export aliases for OSBPL8 gene to outside databases

Previous GC identifers: GC12M076333 GC12M077087 GC12M076678 GC12M075248 GC12M075269 GC12M073797


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for OSBPL8 Gene:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid
receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly
conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for OSBPL8 Gene:
OSBPL8 (oxysterol binding protein-like 8) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBPL10.

Gene Wiki entry for OSBPL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBPL8 gene promoter:
         STAT1   LHX3b/Lhx3b   STAT4   STAT1beta   STAT5A   STAT1alpha   N-Myc   STAT2   LHX3a/Lhx3a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSBPL8 promoter sequence
   Search Chromatin IP Primers for OSBPL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBPL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q14

OSBPL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M076745:  view genomic region     (about GC identifiers)

Start:
76,745,577 bp from pter      End:
76,953,589 bp from pter
Size:
208,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OSBL8_HUMAN, Q9BZF1 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 8  
Size: 889 amino acids; 101196 Da
Sequence caution: Sequence=AAG53411.1; Type=Frameshift; Positions=30; Sequence=BAA95975.3; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for OSBPL8:
1V88 (3D)    
Secondary accessions: A8K1T2 E9PE66 E9PE68 Q52LQ3 Q68D75 Q8WXP8 Q9P277
Alternative splicing: 3 isoforms:  Q9BZF1-1   Q9BZF1-2   Q9BZF1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSBPL8: NX_Q9BZF1

Explore proteomics data for OSBPL8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys697
  • Modification sites at PhosphoSitePlus

  • See OSBPL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003712.1  NP_065892.1  

    ENSEMBL proteins: 
     ENSP00000376939   ENSP00000261183   ENSP00000376940   ENSP00000450238   ENSP00000447893  
     ENSP00000446886   ENSP00000449618   ENSP00000449919   ENSP00000447483   ENSP00000448394  
     ENSP00000447744   ENSP00000447235  

    OSBPL8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OSBPL8
    GenScript Custom Purified and Recombinant Proteins Services for OSBPL8
    Novus Biologicals OSBPL8 Proteins
    Novus Biologicals OSBPL8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSBPL8

     
    Search eBioscience for Proteins for OSBPL8 

    OSBPL8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OSBPL8
    Novus Biologicals OSBPL8 Antibodies
    Abcam antibodies for OSBPL8
    Cloud-Clone Corp. Antibodies for OSBPL8
    ThermoFisher Antibodies for OSBPL8
    LSBio Antibodies in human, mouse, rat for OSBPL8

    OSBPL8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSBPL8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSBPL8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSBPL8
    Cloud-Clone Corp. CLIAs for OSBPL8
    Search eBioscience for ELISAs for OSBPL8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q9BZF1

    ProtoNet protein and cluster: Q9BZF1

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBL8_HUMAN, Q9BZF1
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    Find genes that share domains with OSBPL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015485cholesterol binding IDA17428193
         
    Find genes that share ontologies with OSBPL8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Osbpl8):
     homeostasis/metabolism 

    Find genes that share phenotypes with OSBPL8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSBPL8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSBPL8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSBPL8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSBPL8

    miRNA
    Products:
        
    miRTarBase miRNAs that target OSBPL8:
    hsa-mir-149-5p (MIRT045443), hsa-mir-181b-5p (MIRT047291), hsa-mir-124-3p (MIRT002590), hsa-mir-215-5p (MIRT024824), hsa-mir-192-5p (MIRT026213), hsa-mir-7-5p (MIRT025706), hsa-mir-30a-5p (MIRT028471), hsa-mir-92a-3p (MIRT049706), hsa-mir-375 (MIRT019760), hsa-mir-32-5p (MIRT028261), hsa-mir-132-3p (MIRT021770)

    Block miRNA regulation of human, mouse, rat OSBPL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL8 (see all 65):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-579 hsa-miR-520f hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSBPL8
    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSBPL8

    Clone
    Products:
         
    OriGene clones in human, mouse for OSBPL8 (see all 13)
    OriGene ORF clones in mouse, rat for OSBPL8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OSBPL8 (NM_020841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSBPL8
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSBPL8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with OSBPL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBPL8
    Interactions:

        GeneGlobe Interaction Network for OSBPL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OSBPL8 (Q9BZF13 ENSP000002611834) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=3 
    GABARAPL1Q9H0R83I2D: score=1 
    GABARAPL2P605203I2D: score=1 
    MAP1LC3BQ9GZQ83I2D: score=1 
    TFCP2Q128003I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--
    GO:0010891negative regulation of sequestering of triglyceride IDA--
    GO:0030336negative regulation of cell migration IEA--
    GO:0045444fat cell differentiation IDA--
    GO:0046628positive regulation of insulin receptor signaling pathway IEA--

    Find genes that share ontologies with OSBPL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBPL8 (OSBL8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OSBPL8 gene (2 alternative transcripts): 
    NM_001003712.1  NM_020841.4  

    Unigene Cluster for OSBPL8:

    Oxysterol binding protein-like 8
    Hs.430849  [show with all ESTs]
    Unigene Representative Sequence: NM_020841
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393249 ENST00000261183(uc001sye.1 uc001syf.1 uc001syg.1)
    ENST00000393250 ENST00000548485 ENST00000547540 ENST00000546946(uc001syh.1)
    ENST00000552586 ENST00000548535 ENST00000550865 ENST00000548341 ENST00000553139
    ENST00000549570 ENST00000550628 ENST00000549646 ENST00000551927 ENST00000547544
    ENST00000552178
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OSBPL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL8 (see all 65):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-579 hsa-miR-520f hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSBPL8
    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL8
    Clone
    Products:
         
    OriGene clones in human, mouse for OSBPL8 (see all 13)
    OriGene ORF clones in mouse, rat for OSBPL8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OSBPL8 (NM_020841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OSBPL8
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBPL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL8
      QuantiTect SYBR Green Assays in human, mouse, rat OSBPL8
      QuantiFast Probe-based Assays in human, mouse, rat OSBPL8

    Additional mRNA sequence: 

    AB040884.3 AF173895.1 AF323730.1 AF392452.1 AK055835.1 AK092160.1 AK172813.1 AK289997.1 
    AL049923.1 AL832876.1 BC012935.1 BC082235.1 BC093834.1 BC101529.1 BC111728.1 BC143251.1 
    BX647211.1 CR749542.1 

    18 DOTS entries:

    DT.95316999  DT.455817  DT.95208484  DT.100825005  DT.91792226  DT.95068943  DT.95208480  DT.91722445 
    DT.99992781  DT.95208474  DT.95239914  DT.100029612  DT.121208609  DT.75102523  DT.95208468  DT.95208472 
    DT.95259321  DT.99950176 

    Selected AceView cDNA sequences (see all 254):

    AL832876 BE513563 AI460247 AW674598 AW515071 BU688048 AA047460 CA314202 
    BM827328 BC082235 AA831213 AI364439 BP338184 AA251788 AA258873 AI635764 
    AK092160 BM454764 AI676259 CB242536 NM_020841 AL712413 AA760880 BF055314 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL8 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                              -                                             
    SP4:                                                                                                              -                                             
    SP5:                          -                             -                                                                                                   

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
    SP1:                          -                                             
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for OSBPL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OSBPL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAATATAC
    OSBPL8 Expression
    About this image


    OSBPL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
    OSBPL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBPL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.430849

    UniProtKB/Swiss-Prot: OSBL8_HUMAN, Q9BZF1
    Tissue specificity: Widely expressed

        Custom PCR Arrays for OSBPL8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OSBPL8
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBPL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL8
    QuantiTect SYBR Green Assays in human, mouse, rat OSBPL8
    QuantiFast Probe-based Assays in human, mouse, rat OSBPL8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OSBPL8 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbpl81 , 5 oxysterol binding protein-like 81, 5 89.35(n)1
    96.06(a)1
      10 (58.24 cM)5
    2375421  NM_175489.31  NP_780698.21 
     1111648025 
    chicken
    (Gallus gallus)
    Aves OSBPL81 oxysterol binding protein-like 8 79.29(n)
    84.55(a)
      417866  XM_416108.4  XP_416108.4 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL86
    oxysterol binding protein-like 8
    78(a)
    1 ↔ 1
    5(40655286-40708699)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.235282 Xenopus laevis, Similar to oxysterol binding protein-like more 79.56(n)    BC045000.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01007893.16
    Oxysterol-binding protein
    76(a)
    1 ↔ 1
    4(2269962-2298753) ENSDARG00000039724
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50773
    CG426681
    oxysterol binding3
    CG426681
    49(a)3
    57.36(n)1
    57.98(a)1
      92E23
    424121  NM_001202320.21  NP_001189249.21 
    worm
    (Caenorhabditis elegans)
    Secernentea obr-31 obr-3 55.29(n)
    52(a)
      181495  NM_171795.1  NP_741924.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OSH71 OSH7 49.74(n)
    39.32(a)
      856389   NP_011863.1 


    ENSEMBL Gene Tree for OSBPL8 (if available)
    TreeFam Gene Tree for OSBPL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OSBPL8 gene
    OSBPL102  OSBPL92  OSBPL52  OSBPL112  
    4 SIMAP similar genes for OSBPL8 using alignment to 13 protein entries:     OSBL8_HUMAN (see all proteins):
    DKFZp686C0249    OSBPL5    pp14733    OSBPL9

    Find genes that share paralogs with OSBPL8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OSBPL8 (see all 3893)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347198251,2
    C--76638165(+) AAAAA-/TTTTTT 2 -- int10--------
    rs21221981,2
    C,F,O,A,H--76745172(+) CAATAC/TAGATT 2 -- ds500126Minor allele frequency- T:0.45NS EA NA WA 2846
    rs1380852711,2
    --76745361(+) GTATAA/TAATCT 2 -- ds50010--------
    rs1822096151,2
    --76745432(+) GCAAAA/GCATAC 2 -- ds50010--------
    rs557686681,2
    C--76745633(+) AATTTC/TACAGA 2 -- ut310--------
    rs1852670751,2
    --76745688(+) TAGGAA/GTAATA 2 -- ut310--------
    rs1901171801,2
    --76745823(+) TCACAC/TAAAAC 2 -- ut310--------
    rs1814918781,2
    --76745858(+) ATGAAC/TGGCCA 2 -- ut310--------
    rs1495435911,2
    --76745894(+) GTATAC/TTTAGC 2 -- ut310--------
    rs1855922171,2
    --76746107(+) TATATC/TAATCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for OSBPL8 (76745577 - 76953589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OSBPL8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663126CNV Deletion23128226
    esv2746089CNV Deletion23290073
    esv269262CNV Insertion20981092
    esv274660CNV Insertion20981092
    esv23723CNV Gain19812545
    nsv520195CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSBPL8
    DNA2.0 Custom Variant and Variant Library Synthesis for OSBPL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606736    OMIM disorders: --


    Find genes that share disorders with OSBPL8           About GenesLikeMe

    Genetic Association Database (GAD): OSBPL8
    Human Genome Epidemiology (HuGE) Navigator: OSBPL8 (1 document)

    Export disorders for OSBPL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OSBPL8 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with OSBPL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. (PubMed id 17991739)1, 3, 9 Yan D....Olkkonen V.M. (J. Biol. Chem. 2008)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (J. Lipid Res. 2001)
    8. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (Genomics 2001)
    9. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. Longitudinal growth and growth-plate activity in the lower extremity. (PubMed id 1735225)1, 3 Pritchett J.W. (Clin. Orthop. Relat. Res. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 114882 HGNC: 16396 AceView: OSBPL8 Ensembl:ENSG00000091039 euGenes: HUgn114882
    ECgene: OSBPL8 H-InvDB: OSBPL8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1451

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OSBPL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OSBPL8 gene:
    Search GeneIP for patents involving OSBPL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OSBPL8  
     OriGene qPCR primer pairs and template standards for OSBPL8   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OSBPL8  
     OriGene qSTAR qPCR primer pairs in human, mouse for OSBPL8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OSBPL8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OSBPL8   OriGene Custom Protein Services for OSBPL8  

     
     
     Block miRNA regulation of human, mouse, rat OSBPL8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OSBPL8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBPL8 Predesigned siRNA for gene silencing in human, mouse, rat OSBPL8
     QuantiFast Probe-based Assays in human, mouse, rat OSBPL8 QuantiTect SYBR Green Assays in human, mouse, rat OSBPL8
     Custom PCR Arrays for OSBPL8 Search Chromatin IP Primers for OSBPL8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL8  GeneGlobe Interaction Network for OSBPL8
     Regulatory tfbs in OSBPL8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OSBPL8 GenScript cDNA clones with any tag delivered in your preferred vector for OSBPL8
     GenScript Custom Assay Services for OSBPL8 GenScript Custom overexpressing Cell Line Services for OSBPL8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OSBPL8 (OSBL8)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OSBPL8 antibodies
     OSBPL8 proteins
     OSBPL8 lysates
     Antibodies for OSBPL8
     See all of Abcam's Antibodies, Kits and Proteins for OSBPL8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OSBPL8
     Antibodies for OSBPL8
     ELISAs for OSBPL8
     CLIAs for OSBPL8



     Browse ESI BIO Cell Lines and PureStem Progenitors for OSBPL8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL8
     SwitchGear 3'UTR luciferase reporter plasmids for OSBPL8
     SwitchGear Promoter luciferase reporter plasmids for OSBPL8
     ThermoFisher Antibodies for OSBPL8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSBPL8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OSBPL8
     LSBio Antibodies in human, mouse, rat for OSBPL8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for OSBPL8
      Search eBioscience for proteins for OSBPL8
      Search eBioscience for elisas for OSBPL8
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OSBPL8 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4