OSBPL7 Gene
protein-coding GIFtS: 47
GCID: GC17M045884
|
|
oxysterol binding protein-like 7
| |
Aliases for OSBPL7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Oxysterol Binding Protein-Like 71 2 | | ORP71 2 3 5 | | ORP-72 3 | | OSBP-Related Protein 72 3 | | MGC711501 | | Oxysterol-Binding Protein-Related Protein 72 |
Export aliases for OSBPL7 gene to outside databasesPrevious GC identifers: GC17M045590 GC17M048365 GC17M046226 GC17M046359 GC17M043239 GC17M041255 |
Summaries for OSBPL7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for OSBPL7: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors.Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conservedC-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified.(provided by RefSeq, Jul 2008)
|
Genomic Views for OSBPL7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OSBPL7 gene promoter: Pax-5 STAT5A NF-E2 p45 NF-kappaB Arnt GATA-2 HOXA5 NF-kappaB1 NF-E2 LyF-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for OSBPL7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL7 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21OSBPL7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M045884: view genomic region
(about GC identifiers)
Start:
|
45,884,733 bp from pter |
End:
|
45,899,200 bp from pter |
Size:
|
14,468 bases |
Orientation:
|
minus strand |
|
Proteins for OSBPL7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: OSBL7_HUMAN, Q9BZF2 (See
protein sequence)Recommended Name: Oxysterol-binding protein-related protein 7 Size: 842 amino acids; 95432 Da
Secondary accessions: D3DTT6Explore the universe of human proteins at neXtProt for OSBPL7: NX_Q9BZF2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZF2 OSBPL7 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_665741.1 ENSEMBL proteins: ENSP00000007414 ENSP00000463599 ENSP00000464624 ENSP00000376295 Human Recombinant Protein Products for OSBPL7:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
OSBPL7 for ontologies About GeneDecksing
OSBPL7 Antibody Products: Assay Products for OSBPL7: |
Protein
Domains / Families for OSBPL7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OSBPL7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BZF2ProtoNet protein and cluster: Q9BZF2 2 Blocks protein families: IPB000648 Oxysterol-binding protein IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: OSBL7_HUMAN, Q9BZF2Similarity: Belongs to the OSBP familySimilarity: Contains 1 PH domain |
Function for OSBPL7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
OSBPL7 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL7 |
|
Pathways & Interactions for OSBPL7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSBPL7
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006869 | lipid transport |
IEA | -- | | GO:0045732 | positive regulation of protein catabolic process |
IMP | -- | | GO:0071397 | cellular response to cholesterol |
IMP | -- |
OSBPL7 for ontologies About GeneDecksing
|
Drugs & Compounds for OSBPL7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OSBPL7 Search CenterWatch for drugs/clinical trials and news about OSBPL7 / OSBL7 
|
Transcripts for OSBPL7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OSBPL7 gene (2 alternative transcripts): NM_145798.2 NM_017731.4 Unigene Cluster for OSBPL7: Oxysterol binding protein-like 7 Hs.463320 [show with all ESTs]Unigene Representative Sequence: NM_14579810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000007414(uc002ilx.1) ENST00000583167(uc002ilw.1) ENST00000579728 ENST00000578461 ENST00000580140 ENST00000580808 ENST00000584698 ENST00000580226 ENST00000585051 ENST00000392507
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OSBPL7 (NM_145798) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF323729.1 AF392446.1 AK289523.1 BC028010.1 BC065482.1 7 DOTS entries: DT.75101683 DT.40209993 DT.91737118 DT.95254772 DT.102823767 DT.92415355 DT.92415195 24/83 AceView cDNA sequences (see all 83): NM_145798 AF392446 BQ888716 BQ882308 BQ685591 BM918051 BC028010 AA348234 BQ877195 BQ691746 NM_017731 AF323729 BQ691533 BU857254 BC065482 BU157674 BQ691694 BM977749 BM829047 BF373552 BM674891 BX375836 BM976448 BI871413 GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | · | 23c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for OSBPL7
|
Expression for OSBPL7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OSBPL7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAGCCCGGCC
 About this image See OSBPL7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OSBPL7
SOURCE GeneReport for Unigene cluster: Hs.463320 SABiosciences Custom PCR Arrays for OSBPL7
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL7 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBPL7 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL7 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL7 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL7 |
Orthologs for OSBPL7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for OSBPL7 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for OSBPL7 (if available) TreeFam Gene Tree for OSBPL7 (if available)  |
Paralogs for OSBPL7 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OSBPL7 gene
- OSBP2 OSBPL1A2 OSBPL32 OSBP22 OSBPL22 OSBPL62
4 SIMAP similar genes for OSBPL7 using alignment to 5 protein entries: OSBL7_HUMAN (see all proteins):OSBPL3 OSBPL6 OSBPL1A OSBPL2
OSBPL7 for paralogs About GeneDecksing
|
Genomic Variants for OSBPL7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for OSBPL7 (45884733 - 45899200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OSBPL7 1 Indel: 72971  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL7 |
|
Disorders
/ Diseases for OSBPL7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSBPL7 for disorders About GeneDecksing
OMIM gene information: 606735
OMIM disorders: --
2 diseases for OSBPL7: About MalaCardsopisthorchiasis malaria Human Genome Epidemiology (HuGE) Navigator: OSBPL7 (5 documents) Export disorders for OSBPL7 gene to outside databases
|
Publications for OSBPL7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OSBPL7 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with OSBPL7) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PubMed id 14593528)1, 3, 9 Lehto M....Olkkonen V.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 3 Jaworski C.J.... Rodriguez I.R. (2001)
- The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (2001)
- Expression of oxysterol binding protein isoforms in op isthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tu mor metastasis. (PubMed id 21763455)1 Loilome W....Yongvanit P. (2012)
- OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. (PubMed id 21669198)1 Zhong W.... Yan D. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for OSBPL7 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OSBPL7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OSBPL7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSBPL7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OSBPL7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OSBPL7 gene: Search GeneIP for patents involving OSBPL7
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for OSBPL7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL7 |
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