Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSBPL7 Gene

Aliases for OSBPL7 Gene

  • Oxysterol Binding Protein-Like 7 2 3
  • ORP7 3 4 6
  • OSBP-Related Protein 7 3 4
  • ORP-7 3 4
  • Oxysterol-Binding Protein-Related Protein 7 3

External Ids for OSBPL7 Gene

Summaries for OSBPL7 Gene

Entrez Gene Summary for OSBPL7 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL7 Gene

OSBPL7 (Oxysterol Binding Protein-Like 7) is a Protein Coding gene. Diseases associated with OSBPL7 include opisthorchiasis. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL7 Gene

Genomics for OSBPL7 Gene

Genomic Location for OSBPL7 Gene

Start:
47,807,367 bp from pter
End:
47,821,834 bp from pter
Size:
14,468 bases
Orientation:
Minus strand

Genomic View for OSBPL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL7 Gene

Regulatory Elements for OSBPL7 Gene

Proteins for OSBPL7 Gene

  • Protein details for OSBPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZF2-OSBL7_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 7
    Protein Accession:
    Q9BZF2
    Secondary Accessions:
    • D3DTT6
    • Q6PIV6

    Protein attributes for OSBPL7 Gene

    Size:
    842 amino acids
    Molecular mass:
    95432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSBPL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL7 Gene

Proteomics data for OSBPL7 Gene at MOPED

Post-translational modifications for OSBPL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL7 Gene

No data available for DME Specific Peptides for OSBPL7 Gene

Domains for OSBPL7 Gene

Gene Families for OSBPL7 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBPL7 Gene

UniProtKB/Swiss-Prot:

OSBL7_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9BZF2
Family:
  • Belongs to the OSBP family.:
    • Q9BZF2
genes like me logo Genes that share domains with OSBPL7: view

Function for OSBPL7 Gene

Gene Ontology (GO) - Molecular Function for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21669198
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL7: view

miRNA for OSBPL7 Gene

miRTarBase miRNAs that target OSBPL7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL7 Gene

Localization for OSBPL7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL7 Gene COMPARTMENTS Subcellular localization image for OSBPL7 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
plasma membrane 4
vacuole 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagic vacuole IDA 21669198
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
GO:0097038 perinuclear endoplasmic reticulum IDA 14593528
genes like me logo Genes that share ontologies with OSBPL7: view

Pathways for OSBPL7 Gene

SuperPathways for OSBPL7 Gene

No Data Available

Interacting Proteins for OSBPL7 Gene

Gene Ontology (GO) - Biological Process for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0071397 cellular response to cholesterol IMP 21669198
GO:1901800 positive regulation of proteasomal protein catabolic process IMP 21669198
genes like me logo Genes that share ontologies with OSBPL7: view

No data available for Pathways by source for OSBPL7 Gene

Transcripts for OSBPL7 Gene

Unigene Clusters for OSBPL7 Gene

Oxysterol binding protein-like 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
SP1:
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for OSBPL7 Gene

GeneLoc Exon Structure for
OSBPL7
ECgene alternative splicing isoforms for
OSBPL7

Expression for OSBPL7 Gene

mRNA expression in normal human tissues for OSBPL7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL7 Gene

SOURCE GeneReport for Unigene cluster for OSBPL7 Gene Hs.463320

genes like me logo Genes that share expressions with OSBPL7: view

Orthologs for OSBPL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL7 36
  • 97.94 (n)
  • 97.35 (a)
OSBPL7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL7 36
  • 90.34 (n)
  • 93.23 (a)
OSBPL7 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL7 36
  • 90.1 (n)
  • 93.82 (a)
OSBPL7 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl7 36
  • 87.57 (n)
  • 92.92 (a)
Osbpl7 16
Osbpl7 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBPL7 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL7 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl7 36
  • 87.67 (n)
  • 92.67 (a)
chicken
(Gallus gallus)
Aves OSBPL7 36
  • 69.71 (n)
  • 68.19 (a)
OSBPL7 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL7 37
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3351 36
zebrafish
(Danio rerio)
Actinopterygii osbpl7 37
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 37
  • 35 (a)
OneToMany
Species with no ortholog for OSBPL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL7 Gene

ENSEMBL:
Gene Tree for OSBPL7 (if available)
TreeFam:
Gene Tree for OSBPL7 (if available)

Paralogs for OSBPL7 Gene

Paralogs for OSBPL7 Gene

Selected SIMAP similar genes for OSBPL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSBPL7: view

Variants for OSBPL7 Gene

Sequence variations from dbSNP and Humsavar for OSBPL7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs732840 -- 47,821,226(-) CCCCC(A/G)TCTCA intron-variant
rs878171 -- 47,819,112(+) TGAAG(C/T)GTTGG intron-variant
rs916798 -- 47,818,205(-) GGGGA(A/T)AATGT intron-variant
rs991108 -- 47,809,776(-) GATAA(C/T)GGATG intron-variant
rs1008933 -- 47,807,195(+) caatg(C/T)gacct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OSBPL7 Gene

Variant ID Type Subtype PubMed ID
nsv908572 CNV Loss 21882294
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680
esv23195 CNV Loss 19812545

Relevant External Links for OSBPL7 Gene

HapMap Linkage Disequilibrium report
OSBPL7

Disorders for OSBPL7 Gene

(1) MalaCards Diseases for OSBPL7 Gene

Search for OSBPL7 Gene in MalaCards »

Relevant External Links for OSBPL7

Genetic Association Database (GAD)
OSBPL7
Human Genome Epidemiology (HuGE) Navigator
OSBPL7
genes like me logo Genes that share disorders with OSBPL7: view

No data available for UniProtKB/Swiss-Prot for OSBPL7 Gene

Publications for OSBPL7 Gene

  1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 2 3 23
  2. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 3 4
  3. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for OSBPL7 Gene

Sources for OSBPL7 Gene

Back to Top

Content