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Aliases for OSBPL7 Gene

Aliases for OSBPL7 Gene

  • Oxysterol Binding Protein Like 7 2 3 5
  • Oxysterol Binding Protein-Like 7 2 3
  • OSBP-Related Protein 7 3 4
  • ORP-7 3 4
  • ORP7 3 4

External Ids for OSBPL7 Gene

Previous GeneCards Identifiers for OSBPL7 Gene

  • GC17M045590
  • GC17M048365
  • GC17M046226
  • GC17M046359
  • GC17M043239
  • GC17M045884
  • GC17M041255

Summaries for OSBPL7 Gene

Entrez Gene Summary for OSBPL7 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL7 Gene

OSBPL7 (Oxysterol Binding Protein Like 7) is a Protein Coding gene. Diseases associated with OSBPL7 include opisthorchiasis. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL7 Gene

Genomics for OSBPL7 Gene

Regulatory Elements for OSBPL7 Gene

Promoters for OSBPL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSBPL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSBPL7 Gene

Chromosome:
17
Start:
47,807,367 bp from pter
End:
47,821,834 bp from pter
Size:
14,468 bases
Orientation:
Minus strand

Genomic View for OSBPL7 Gene

Genes around OSBPL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL7 Gene

Proteins for OSBPL7 Gene

  • Protein details for OSBPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZF2-OSBL7_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 7
    Protein Accession:
    Q9BZF2
    Secondary Accessions:
    • D3DTT6
    • Q6PIV6

    Protein attributes for OSBPL7 Gene

    Size:
    842 amino acids
    Molecular mass:
    95432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSBPL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL7 Gene

Proteomics data for OSBPL7 Gene at MOPED

Post-translational modifications for OSBPL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL7 Gene

No data available for DME Specific Peptides for OSBPL7 Gene

Domains & Families for OSBPL7 Gene

Protein Domains for OSBPL7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZF2

UniProtKB/Swiss-Prot:

OSBL7_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL7: view

Function for OSBPL7 Gene

genes like me logo Genes that share phenotypes with OSBPL7: view

Animal Model Products

CRISPR Products

miRNA for OSBPL7 Gene

miRTarBase miRNAs that target OSBPL7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL7 Gene

Localization for OSBPL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL7 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL7 Gene COMPARTMENTS Subcellular localization image for OSBPL7 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
vacuole 4

Gene Ontology (GO) - Cellular Components for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
genes like me logo Genes that share ontologies with OSBPL7: view

Pathways & Interactions for OSBPL7 Gene

SuperPathways for OSBPL7 Gene

No Data Available

Interacting Proteins for OSBPL7 Gene

Gene Ontology (GO) - Biological Process for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL7: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL7 Gene

Drugs & Compounds for OSBPL7 Gene

No Compound Related Data Available

Transcripts for OSBPL7 Gene

Unigene Clusters for OSBPL7 Gene

Oxysterol binding protein-like 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
SP1:
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for OSBPL7 Gene

GeneLoc Exon Structure for
OSBPL7
ECgene alternative splicing isoforms for
OSBPL7

Expression for OSBPL7 Gene

mRNA expression in normal human tissues for OSBPL7 Gene

Protein differential expression in normal tissues from HIPED for OSBPL7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), CD8 Tcells (17.6), Frontal cortex (7.1), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL7 Gene



SOURCE GeneReport for Unigene cluster for OSBPL7 Gene Hs.463320

mRNA Expression by UniProt/SwissProt for OSBPL7 Gene

Q9BZF2-OSBL7_HUMAN
Tissue specificity: Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes.
genes like me logo Genes that share expression patterns with OSBPL7: view

Protein tissue co-expression partners for OSBPL7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OSBPL7 Gene

Orthologs for OSBPL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSBPL7 35
  • 90.34 (n)
  • 93.23 (a)
OSBPL7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL7 35
  • 90.1 (n)
  • 93.82 (a)
OSBPL7 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl7 35
  • 87.57 (n)
  • 92.92 (a)
Osbpl7 16
Osbpl7 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSBPL7 35
  • 97.94 (n)
  • 97.35 (a)
OSBPL7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl7 35
  • 87.67 (n)
  • 92.67 (a)
oppossum
(Monodelphis domestica)
Mammalia OSBPL7 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL7 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL7 35
  • 69.71 (n)
  • 68.19 (a)
OSBPL7 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL7 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3351 35
zebrafish
(Danio rerio)
Actinopterygii osbpl7 36
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 36
  • 35 (a)
OneToMany
Species with no ortholog for OSBPL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL7 Gene

ENSEMBL:
Gene Tree for OSBPL7 (if available)
TreeFam:
Gene Tree for OSBPL7 (if available)

Paralogs for OSBPL7 Gene

Paralogs for OSBPL7 Gene

(4) SIMAP similar genes for OSBPL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSBPL7: view

Variants for OSBPL7 Gene

Sequence variations from dbSNP and Humsavar for OSBPL7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs35437144 - 47,818,519(-) CAGTA(C/T)TGCTC nc-transcript-variant, reference, missense
rs8076196 - 47,818,542(+) CGGGG(C/T)ATGTC nc-transcript-variant, reference, missense
rs8071195 - 47,818,361(+) TAGCT(G/T)CTGTT nc-transcript-variant, reference, missense
rs878171 -- 47,819,112(+) TGAAG(C/T)GTTGG intron-variant
rs732840 -- 47,821,226(-) CCCCC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL7 Gene

Variant ID Type Subtype PubMed ID
nsv908572 CNV Loss 21882294
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680
esv23195 CNV Loss 19812545

Variation tolerance for OSBPL7 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL7 Gene

HapMap Linkage Disequilibrium report
OSBPL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL7 Gene

Disorders for OSBPL7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSBPL7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
opisthorchiasis
  • infection by opisthorchis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OSBPL7

Genetic Association Database (GAD)
OSBPL7
Human Genome Epidemiology (HuGE) Navigator
OSBPL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSBPL7
genes like me logo Genes that share disorders with OSBPL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSBPL7 Gene

Publications for OSBPL7 Gene

  1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 2 3 4 23 67
  2. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 2 3
  3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. (PMID: 21763455) Loilome W. … Yongvanit P. (Parasitol. Int. 2012) 3

Products for OSBPL7 Gene

Sources for OSBPL7 Gene

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