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Aliases for OSBPL7 Gene

Aliases for OSBPL7 Gene

  • Oxysterol Binding Protein-Like 7 2 3
  • ORP7 3 4 6
  • OSBP-Related Protein 7 3 4
  • ORP-7 3 4
  • Oxysterol-Binding Protein-Related Protein 7 3

External Ids for OSBPL7 Gene

Previous GeneCards Identifiers for OSBPL7 Gene

  • GC17M045590
  • GC17M048365
  • GC17M046226
  • GC17M046359
  • GC17M043239
  • GC17M045884
  • GC17M041255

Summaries for OSBPL7 Gene

Entrez Gene Summary for OSBPL7 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL7 Gene

OSBPL7 (Oxysterol Binding Protein-Like 7) is a Protein Coding gene. Diseases associated with OSBPL7 include opisthorchiasis. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL7 Gene

Genomics for OSBPL7 Gene

Regulatory Elements for OSBPL7 Gene

Genomic Location for OSBPL7 Gene

47,807,367 bp from pter
47,821,834 bp from pter
14,468 bases
Minus strand

Genomic View for OSBPL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL7 Gene

Proteins for OSBPL7 Gene

  • Protein details for OSBPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 7
    Protein Accession:
    Secondary Accessions:
    • D3DTT6
    • Q6PIV6

    Protein attributes for OSBPL7 Gene

    842 amino acids
    Molecular mass:
    95432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSBPL7 Gene


neXtProt entry for OSBPL7 Gene

Proteomics data for OSBPL7 Gene at MOPED

Post-translational modifications for OSBPL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL7 Gene

Antibody Products

No data available for DME Specific Peptides for OSBPL7 Gene

Domains for OSBPL7 Gene

Protein Domains for OSBPL7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Belongs to the OSBP family.
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL7: view

Function for OSBPL7 Gene

Gene Ontology (GO) - Molecular Function for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21669198
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL7: view

Animal Model Products

CRISPR Products

miRNA for OSBPL7 Gene

miRTarBase miRNAs that target OSBPL7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL7 Gene

Localization for OSBPL7 Gene

Subcellular locations from

Jensen Localization Image for OSBPL7 Gene COMPARTMENTS Subcellular localization image for OSBPL7 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
plasma membrane 4
vacuole 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagic vacuole IDA 21669198
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
GO:0097038 perinuclear endoplasmic reticulum IDA 14593528
genes like me logo Genes that share ontologies with OSBPL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSBPL7 Gene

Pathways for OSBPL7 Gene

SuperPathways for OSBPL7 Gene

No Data Available

Interacting Proteins for OSBPL7 Gene

Gene Ontology (GO) - Biological Process for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0071397 cellular response to cholesterol IMP 21669198
GO:1901800 positive regulation of proteasomal protein catabolic process IMP 21669198
genes like me logo Genes that share ontologies with OSBPL7: view

No data available for Pathways by source for OSBPL7 Gene

Transcripts for OSBPL7 Gene

Unigene Clusters for OSBPL7 Gene

Oxysterol binding protein-like 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - - - - - -
SP4: - -
SP7: - - - - - - - - - - - - - - - - - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
SP2: - - - -
SP5: -

Relevant External Links for OSBPL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL7 Gene

mRNA expression in normal human tissues for OSBPL7 Gene

Protein differential expression in normal tissues for OSBPL7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), CD8 Tcells (17.6), Frontal cortex (7.1), and Pancreas (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL7 Gene

SOURCE GeneReport for Unigene cluster for OSBPL7 Gene Hs.463320

genes like me logo Genes that share expressions with OSBPL7: view

Expression partners for OSBPL7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OSBPL7 Gene

Orthologs for OSBPL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSBPL7 35
  • 90.34 (n)
  • 93.23 (a)
  • 93 (a)
(Canis familiaris)
Mammalia OSBPL7 35
  • 90.1 (n)
  • 93.82 (a)
  • 85 (a)
(Mus musculus)
Mammalia Osbpl7 35
  • 87.57 (n)
  • 92.92 (a)
Osbpl7 16
Osbpl7 36
  • 81 (a)
(Pan troglodytes)
Mammalia OSBPL7 35
  • 97.94 (n)
  • 97.35 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Osbpl7 35
  • 87.67 (n)
  • 92.67 (a)
(Monodelphis domestica)
Mammalia OSBPL7 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia OSBPL7 36
  • 88 (a)
(Gallus gallus)
Aves OSBPL7 35
  • 69.71 (n)
  • 68.19 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia OSBPL7 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3351 35
(Danio rerio)
Actinopterygii osbpl7 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 36
  • 35 (a)
Species with no ortholog for OSBPL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL7 Gene

Gene Tree for OSBPL7 (if available)
Gene Tree for OSBPL7 (if available)

Paralogs for OSBPL7 Gene

Paralogs for OSBPL7 Gene

(4) SIMAP similar genes for OSBPL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSBPL7: view

Variants for OSBPL7 Gene

Sequence variations from dbSNP and Humsavar for OSBPL7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs732840 -- 47,821,226(-) CCCCC(A/G)TCTCA intron-variant
rs878171 -- 47,819,112(+) TGAAG(C/T)GTTGG intron-variant
rs916798 -- 47,818,205(-) GGGGA(A/T)AATGT intron-variant
rs991108 -- 47,809,776(-) GATAA(C/T)GGATG intron-variant
rs1008933 -- 47,807,195(+) caatg(C/T)gacct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OSBPL7 Gene

Variant ID Type Subtype PubMed ID
nsv908572 CNV Loss 21882294
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680
esv23195 CNV Loss 19812545

Relevant External Links for OSBPL7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL7 Gene

Disorders for OSBPL7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OSBPL7 Gene in MalaCards »

(1) Disease for OSBPL7 Gene

Relevant External Links for OSBPL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OSBPL7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OSBPL7 Gene

Publications for OSBPL7 Gene

  1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 2 3 23
  2. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 3 4
  3. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for OSBPL7 Gene

Sources for OSBPL7 Gene

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