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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSBPL7 Gene

protein-coding   GIFtS: 47
GCID: GC17M045884

oxysterol binding protein-like 7

 Explore 2 diseases affiliated with
OSBPL7 via our new
 Human Malady Compendium 
Biological research products
for OSBPL7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Oxysterol Binding Protein-Like 71 2
ORP71 2 3 5
ORP-72 3
OSBP-Related Protein 72 3
MGC711501
Oxysterol-Binding Protein-Related Protein 72

External Ids:    HGNC: 163871   Entrez Gene: 1148812   Ensembl: ENSG000000060257   OMIM: 6067355   UniProtKB: Q9BZF23   

Export aliases for OSBPL7 gene to outside databases

Previous GC identifers: GC17M045590 GC17M048365 GC17M046226 GC17M046359 GC17M043239 GC17M041255


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSBPL7:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors.
Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved
C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified.
(provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSBPL7 gene promoter:
         Pax-5   STAT5A   NF-E2 p45   NF-kappaB   Arnt   GATA-2   HOXA5   NF-kappaB1   NF-E2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSBPL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for OSBPL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21

OSBPL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M045884:  view genomic region     (about GC identifiers)

Start:
45,884,733 bp from pter      End:
45,899,200 bp from pter
Size:
14,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSBL7_HUMAN, Q9BZF2 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 7  
Size: 842 amino acids; 95432 Da
Secondary accessions: D3DTT6

Explore the universe of human proteins at neXtProt for OSBPL7: NX_Q9BZF2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZF2

  • OSBPL7 Protein expression data from MOPED and PaxDb:    About this image 
    OSBPL7 Protein Expression
    REFSEQ proteins: NP_665741.1  
    ENSEMBL proteins: 
     ENSP00000007414   ENSP00000463599   ENSP00000464624   ENSP00000376295  

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    Uscn Proteins for OSBPL7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005776autophagic vacuole IDA--
    GO:0005829cytosol IDA14593528
    GO:0005886plasma membrane IDA14593528
    GO:0097038perinuclear endoplasmic reticulum IDA14593528

    OSBPL7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OSBPL7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q9BZF2

    ProtoNet protein and cluster: Q9BZF2

    2 Blocks protein families:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBL7_HUMAN, Q9BZF2
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IEA--
    GO:0015485cholesterol binding IDA17428193
         
    OSBPL7 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target OSBPL7:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBPL7
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    hsa-miR-3673 hsa-miR-676 hsa-miR-1285 hsa-miR-221 hsa-miR-1205 hsa-miR-650 hsa-miR-4314 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSBPL7

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--
    GO:0045732positive regulation of protein catabolic process IMP--
    GO:0071397cellular response to cholesterol IMP--

    OSBPL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSBPL7
    Search CenterWatch for drugs/clinical trials and news about OSBPL7 / OSBL7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSBPL7 gene (2 alternative transcripts): 
    NM_145798.2  NM_017731.4  

    Unigene Cluster for OSBPL7:

    Oxysterol binding protein-like 7
    Hs.463320  [show with all ESTs]
    Unigene Representative Sequence: NM_145798
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000007414(uc002ilx.1) ENST00000583167(uc002ilw.1) ENST00000579728
    ENST00000578461 ENST00000580140 ENST00000580808 ENST00000584698 ENST00000580226
    ENST00000585051 ENST00000392507

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBPL7 (see all 22):
    hsa-miR-3673 hsa-miR-676 hsa-miR-1285 hsa-miR-221 hsa-miR-1205 hsa-miR-650 hsa-miR-4314 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF323729.1 AF392446.1 AK289523.1 BC028010.1 BC065482.1 

    7 DOTS entries:

    DT.75101683  DT.40209993  DT.91737118  DT.95254772  DT.102823767  DT.92415355  DT.92415195 

    24/83 AceView cDNA sequences (see all 83):

    NM_145798 AF392446 BQ888716 BQ882308 BQ685591 BM918051 BC028010 AA348234 
    BQ877195 BQ691746 NM_017731 AF323729 BQ691533 BU857254 BC065482 BU157674 
    BQ691694 BM977749 BM829047 BF373552 BM674891 BX375836 BM976448 BI871413 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                                            -     -                             -     -                                                                     
    SP2:                                            -     -                             -     -                                         -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                -     -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
    SP1:                                                                  
    SP2:  -     -     -     -                                             
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                -                                 


    ECgene alternative splicing isoforms for OSBPL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSBPL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCCCGGCC
    OSBPL7 Expression
    About this image
    See OSBPL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSBPL7

    SOURCE GeneReport for Unigene cluster: Hs.463320
        SABiosciences Custom PCR Arrays for OSBPL7

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBPL7 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OSBPL71 oxysterol binding protein-like 7 70.53(n)
    69.31(a)
      100857443  XM_003642799.1  XP_003642847.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL76
    --
    70(a)
    1 ↔ 1
    6(74486570-74511756)
    zebrafish
    (Danio rerio)
    Actinopterygii osbpl76
    oxysterol binding protein-like 7
    42(a)
    1 ↔ 1
    12(30321750-30343118)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORP1B1 oxysterol binding protein-related protein 1B 48.36(n)
    45.07(a)
      817654  NM_128657.1  NP_180660.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07047001 hypothetical protein 52.34(n)
    48.78(a)
      9270471  NM_001186675.1  NP_001173604.1 


    ENSEMBL Gene Tree for OSBPL7 (if available)
    TreeFam Gene Tree for OSBPL7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OSBPL7 gene
    OSBP2  OSBPL1A2  OSBPL32  OSBP22  OSBPL22  OSBPL62  
    4 SIMAP similar genes for OSBPL7 using alignment to 5 protein entries:     OSBL7_HUMAN (see all proteins):
    OSBPL3    OSBPL6    OSBPL1A    OSBPL2

    OSBPL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 NCBI SNPs in OSBPL7 are shown (see all 384    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495081381,2
    --45884315(+) CAGGGC/TTGGCT 1 -- ds50010--------
    rs99045031,2
    C,F,A,H--45884372(+) TCGGGT/CGGTTG 1 -- ds500122Minor allele frequency- C:0.26NS EA NA WA CSA 2349
    rs116523741,2
    C,F,H--45884421(+) tcccaT/Actctg 1 -- ds50012Minor allele frequency- A:0.05NA 126
    rs1809160821,2
    --45884431(+) GCCTAC/TGTCTC 1 -- ds50010--------
    rs776388201,2
    --45884439(+) CTCCAC/AGTGGC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs760984861,2
    F--45884486(+) CTTGCG/ATACGT 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1861550721,2
    --45884495(+) GTCTGC/TGTGCC 1 -- ds50010--------
    rs98967121,2
    C,F,A,H--45884543(+) AGTAGG/AGCCAC 1 -- ds500123Minor allele frequency- A:0.27NS EA NA WA CSA 2101
    rs10089331,2
    C,H--45884561(+) CAATGC/TGACCT 1 -- ds500114Minor allele frequency- T:0.01NA WA CSA EA 379
    rs607969241,2
    C--45884572(+) CATTTT/CAACTT 1 -- ds50012Minor allele frequency- C:0.15WA 120

    HapMap Linkage Disequilibrium report for OSBPL7 (45884733 - 45899200 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OSBPL7
         1 Indel: 72971

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OSBPL7 for disorders           About GeneDecksing

    OMIM gene information: 606735    OMIM disorders: --

    2 diseases for OSBPL7:    About MalaCards
    opisthorchiasis    malaria

    Human Genome Epidemiology (HuGE) Navigator: OSBPL7 (5 documents)

    Export disorders for OSBPL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSBPL7 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with OSBPL7)
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    1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PubMed id 14593528)1, 3, 9 Lehto M....Olkkonen V.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 3 Jaworski C.J.... Rodriguez I.R. (2001)
    4. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (2001)
    5. Expression of oxysterol binding protein isoforms in op isthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tu mor metastasis. (PubMed id 21763455)1 Loilome W....Yongvanit P. (2012)
    6. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. (PubMed id 21669198)1 Zhong W.... Yan D. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114881 HGNC: 16387 AceView: OSBPL7 Ensembl:ENSG00000006025 euGenes: HUgn114881
    ECgene: OSBPL7 H-InvDB: OSBPL7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSBPL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSBPL7 gene:
    Search GeneIP for patents involving OSBPL7

    GeneCards and IP:
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