Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSBPL6 Gene

Aliases for OSBPL6 Gene

  • Oxysterol Binding Protein-Like 6 2 3
  • OSBP-Related Protein 6 2 3 4
  • ORP6 3 4 6
  • ORP-6 3 4
  • Oxysterol-Binding Protein-Related Protein 6 3

External Ids for OSBPL6 Gene

Summaries for OSBPL6 Gene

Entrez Gene Summary for OSBPL6 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL6 Gene

OSBPL6 (Oxysterol Binding Protein-Like 6) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is OSBP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL6 Gene

Genomics for OSBPL6 Gene

Genomic Location for OSBPL6 Gene

Start:
178,194,481 bp from pter
End:
178,399,433 bp from pter
Size:
204,953 bases
Orientation:
Plus strand

Genomic View for OSBPL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL6 Gene

Regulatory Elements for OSBPL6 Gene

Proteins for OSBPL6 Gene

  • Protein details for OSBPL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZF3-OSBL6_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 6
    Protein Accession:
    Q9BZF3
    Secondary Accessions:
    • B4DTW1
    • C4AMC0
    • C4AME4
    • D3DPF6
    • D3DPF7
    • Q4ZG68
    • Q53T68
    • Q59H61
    • Q7Z4Q1
    • Q86V84
    • Q8N9T0
    • Q96SR1

    Protein attributes for OSBPL6 Gene

    Size:
    934 amino acids
    Molecular mass:
    106306 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55223.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92135.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL6 Gene

neXtProt entry for OSBPL6 Gene

Proteomics data for OSBPL6 Gene at MOPED

Post-translational modifications for OSBPL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSBPL6 Gene

Domains for OSBPL6 Gene

Gene Families for OSBPL6 Gene

HGNC:
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBPL6 Gene

Suggested Antigen Peptide Sequences for OSBPL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZF3

UniProtKB/Swiss-Prot:

OSBL6_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9BZF3
Family:
  • Belongs to the OSBP family.:
    • Q9BZF3
genes like me logo Genes that share domains with OSBPL6: view

Function for OSBPL6 Gene

Gene Ontology (GO) - Molecular Function for OSBPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with OSBPL6: view

miRNA for OSBPL6 Gene

miRTarBase miRNAs that target OSBPL6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL6 Gene

Localization for OSBPL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL6 Gene COMPARTMENTS Subcellular localization image for OSBPL6 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSBPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
GO:0031965 nuclear membrane IDA 14593528
GO:0097038 perinuclear endoplasmic reticulum IDA 14593528
genes like me logo Genes that share ontologies with OSBPL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSBPL6 Gene

Pathways for OSBPL6 Gene

SuperPathways for OSBPL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL6: view

No data available for Pathways by source for OSBPL6 Gene

Transcripts for OSBPL6 Gene

Unigene Clusters for OSBPL6 Gene

Oxysterol binding protein-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: -
SP7: - - - - - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -

Relevant External Links for OSBPL6 Gene

GeneLoc Exon Structure for
OSBPL6
ECgene alternative splicing isoforms for
OSBPL6

Expression for OSBPL6 Gene

mRNA expression in normal human tissues for OSBPL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL6 Gene

This gene is overexpressed in Muscle - Skeletal (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL6 Gene

SOURCE GeneReport for Unigene cluster for OSBPL6 Gene Hs.318775

mRNA Expression by UniProt/SwissProt for OSBPL6 Gene

Q9BZF3-OSBL6_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with OSBPL6: view

Orthologs for OSBPL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL6 35
  • 98.67 (n)
  • 98.64 (a)
OSBPL6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL6 35
  • 93.88 (n)
  • 98.12 (a)
OSBPL6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL6 35
  • 93.79 (n)
  • 98.07 (a)
OSBPL6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl6 35
  • 89.99 (n)
  • 97.81 (a)
Osbpl6 16
Osbpl6 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBPL6 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Osbpl6 35
  • 89.33 (n)
  • 97.32 (a)
chicken
(Gallus gallus)
Aves OSBPL6 35
  • 82.33 (n)
  • 90.99 (a)
OSBPL6 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL6 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl6 35
  • 78.16 (n)
  • 86.14 (a)
zebrafish
(Danio rerio)
Actinopterygii osbpl6 35
  • 71.75 (n)
  • 78.61 (a)
osbpl6 36
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 36
  • 38 (a)
OneToMany
Species with no ortholog for OSBPL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL6 Gene

ENSEMBL:
Gene Tree for OSBPL6 (if available)
TreeFam:
Gene Tree for OSBPL6 (if available)

Paralogs for OSBPL6 Gene

Paralogs for OSBPL6 Gene

Selected SIMAP similar genes for OSBPL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSBPL6: view

Variants for OSBPL6 Gene

Sequence variations from dbSNP and Humsavar for OSBPL6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs101266 -- 178,248,334(+) AAATA(A/C)AATTT intron-variant
rs147180 -- 178,237,194(+) CTTTC(A/G)TGTCC intron-variant
rs168009 -- 178,197,862(+) GAGTT(A/G)TCACA intron-variant
rs170791 -- 178,234,545(-) GTTTT(G/T)TAAGA intron-variant
rs170792 -- 178,196,441(+) AGTGG(A/C)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL6 Gene

Variant ID Type Subtype PubMed ID
nsv875452 CNV Gain 21882294
dgv4371n71 CNV Loss 21882294
nsv511090 CNV Complex 20534489
esv21696 CNV Loss 19812545
nsv3056 CNV Insertion 18451855
nsv3057 CNV Insertion 18451855
esv2662653 CNV Deletion 23128226
nsv834466 CNV Gain 17160897
esv268453 CNV Insertion 20981092
esv274681 CNV Insertion 20981092
nsv834467 CNV Loss 17160897

Relevant External Links for OSBPL6 Gene

HapMap Linkage Disequilibrium report
OSBPL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL6 Gene

Disorders for OSBPL6 Gene

Relevant External Links for OSBPL6

Genetic Association Database (GAD)
OSBPL6
Human Genome Epidemiology (HuGE) Navigator
OSBPL6
genes like me logo Genes that share disorders with OSBPL6: view

No data available for UniProtKB/Swiss-Prot for OSBPL6 Gene

Publications for OSBPL6 Gene

  1. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 2 3 4
  2. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski C.J. … Rodriguez I.R. (Genomics 2001) 3 4
  3. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PMID: 10588946) Laitinen S. … Ikonen E. (J. Lipid Res. 1999) 3 23
  4. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for OSBPL6 Gene

Sources for OSBPL6 Gene

Back to Top

Content