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Aliases for OSBPL6 Gene

Aliases for OSBPL6 Gene

  • Oxysterol Binding Protein Like 6 2 3 5
  • OSBP-Related Protein 6 2 3 4
  • Oxysterol Binding Protein-Like 6 2 3
  • ORP-6 3 4
  • ORP6 3 4

External Ids for OSBPL6 Gene

Previous GeneCards Identifiers for OSBPL6 Gene

  • GC02P177121
  • GC02P177730
  • GC02P179023
  • GC02P179261
  • GC02P178884
  • GC02P178767
  • GC02P170932

Summaries for OSBPL6 Gene

Entrez Gene Summary for OSBPL6 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL6 Gene

OSBPL6 (Oxysterol Binding Protein Like 6) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBP.

UniProtKB/Swiss-Prot for OSBPL6 Gene

  • Weakly binds 25-hydroxycholesterol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL6 Gene

Genomics for OSBPL6 Gene

Regulatory Elements for OSBPL6 Gene

Enhancers for OSBPL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSBPL6 on UCSC Golden Path with GeneCards custom track

Promoters for OSBPL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSBPL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSBPL6 Gene

178,194,481 bp from pter
178,402,891 bp from pter
208,411 bases
Plus strand

Genomic View for OSBPL6 Gene

Genes around OSBPL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL6 Gene

Proteins for OSBPL6 Gene

  • Protein details for OSBPL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 6
    Protein Accession:
    Secondary Accessions:
    • B4DTW1
    • C4AMC0
    • C4AME4
    • D3DPF6
    • D3DPF7
    • Q4ZG68
    • Q53T68
    • Q59H61
    • Q7Z4Q1
    • Q86V84
    • Q8N9T0
    • Q96SR1

    Protein attributes for OSBPL6 Gene

    934 amino acids
    Molecular mass:
    106306 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55223.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92135.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL6 Gene

neXtProt entry for OSBPL6 Gene

Proteomics data for OSBPL6 Gene at MOPED

Post-translational modifications for OSBPL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OSBPL6

No data available for DME Specific Peptides for OSBPL6 Gene

Domains & Families for OSBPL6 Gene

Gene Families for OSBPL6 Gene

Protein Domains for OSBPL6 Gene

Suggested Antigen Peptide Sequences for OSBPL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Belongs to the OSBP family.
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL6: view

Function for OSBPL6 Gene

Molecular function for OSBPL6 Gene

UniProtKB/Swiss-Prot Function:
Weakly binds 25-hydroxycholesterol.
genes like me logo Genes that share phenotypes with OSBPL6: view

Animal Model Products

CRISPR Products

miRNA for OSBPL6 Gene

miRTarBase miRNAs that target OSBPL6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL6 Gene

Localization for OSBPL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL6 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for OSBPL6 Gene COMPARTMENTS Subcellular localization image for OSBPL6 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSBPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
genes like me logo Genes that share ontologies with OSBPL6: view

Pathways & Interactions for OSBPL6 Gene

SuperPathways for OSBPL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL6 Gene


No data available for Pathways by source and SIGNOR curated interactions for OSBPL6 Gene

Drugs & Compounds for OSBPL6 Gene

No Compound Related Data Available

Transcripts for OSBPL6 Gene

Unigene Clusters for OSBPL6 Gene

Oxysterol binding protein-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: -
SP7: - - - - - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
SP7: - - - - - -

Relevant External Links for OSBPL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL6 Gene

mRNA expression in normal human tissues for OSBPL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL6 Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Protein differential expression in normal tissues from HIPED for OSBPL6 Gene

This gene is overexpressed in Frontal cortex (37.3), Fetal Brain (18.0), and Retina (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL6 Gene

SOURCE GeneReport for Unigene cluster for OSBPL6 Gene Hs.318775

mRNA Expression by UniProt/SwissProt for OSBPL6 Gene

Tissue specificity: Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).
genes like me logo Genes that share expression patterns with OSBPL6: view

Protein tissue co-expression partners for OSBPL6 Gene

- Elite partner

Primer Products

Orthologs for OSBPL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSBPL6 35
  • 93.88 (n)
  • 98.12 (a)
  • 98 (a)
(Canis familiaris)
Mammalia OSBPL6 35
  • 93.79 (n)
  • 98.07 (a)
  • 98 (a)
(Mus musculus)
Mammalia Osbpl6 35
  • 89.99 (n)
  • 97.81 (a)
Osbpl6 16
Osbpl6 36
  • 97 (a)
(Pan troglodytes)
Mammalia OSBPL6 35
  • 98.67 (n)
  • 98.64 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Osbpl6 35
  • 89.33 (n)
  • 97.32 (a)
(Monodelphis domestica)
Mammalia OSBPL6 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 94 (a)
(Gallus gallus)
Aves OSBPL6 35
  • 82.33 (n)
  • 90.99 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia OSBPL6 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl6 35
  • 78.16 (n)
  • 86.14 (a)
(Danio rerio)
Actinopterygii osbpl6 35
  • 71.75 (n)
  • 78.61 (a)
osbpl6 36
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 36
  • 38 (a)
Species with no ortholog for OSBPL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL6 Gene

Gene Tree for OSBPL6 (if available)
Gene Tree for OSBPL6 (if available)

Paralogs for OSBPL6 Gene

Paralogs for OSBPL6 Gene

(2) SIMAP similar genes for OSBPL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSBPL6: view

Variants for OSBPL6 Gene

Sequence variations from dbSNP and Humsavar for OSBPL6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34874235 - 178,324,247(-) GCTCC(A/G/T)GTTCT intron-variant, reference, missense
rs35032920 - 178,324,232(-) ATTGC(C/T)GACTT intron-variant, reference, missense
rs368767 -- 178,193,192(+) AGAAG(A/G)AGTAA upstream-variant-2KB
rs374120 -- 178,229,839(-) tttcc(C/T)tttct intron-variant
rs390991 -- 178,210,821(-) tgttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL6 Gene

Variant ID Type Subtype PubMed ID
nsv875452 CNV Gain 21882294
dgv4371n71 CNV Loss 21882294
nsv511090 CNV Complex 20534489
esv21696 CNV Loss 19812545
nsv3056 CNV Insertion 18451855
nsv3057 CNV Insertion 18451855
esv2662653 CNV Deletion 23128226
nsv834466 CNV Gain 17160897
esv268453 CNV Insertion 20981092
esv274681 CNV Insertion 20981092
nsv834467 CNV Loss 17160897

Variation tolerance for OSBPL6 Gene

Residual Variation Intolerance Score: 3.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSBPL6 Gene

Disorders for OSBPL6 Gene

Relevant External Links for OSBPL6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSBPL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL6 Gene

Publications for OSBPL6 Gene

  1. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 2 3 4 67
  2. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 3 23
  3. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PMID: 10588946) Laitinen S. … Ikonen E. (J. Lipid Res. 1999) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for OSBPL6 Gene

Sources for OSBPL6 Gene