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OSBPL6 Gene

protein-coding   GIFtS: 52
GCID: GC02P179023

Oxysterol Binding Protein-Like 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxysterol Binding Protein-Like 61 2
OSBP-Related Protein 61 2 3
ORP62 3 5
ORP-62 3
Oxysterol-Binding Protein-Related Protein 62

External Ids:    HGNC: 163881   Entrez Gene: 1148802   Ensembl: ENSG000000791567   OMIM: 6067345   UniProtKB: Q9BZF33   

Export aliases for OSBPL6 gene to outside databases

Previous GC identifers: GC02P177121 GC02P177730 GC02P179261 GC02P178884 GC02P178767 GC02P170932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSBPL6 Gene:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid
receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal
OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for OSBPL6 Gene:
OSBPL6 (oxysterol binding protein-like 6) is a protein-coding gene. Diseases associated with OSBPL6 include pulmonary function, and breast cancer. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is OSBPL1A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBPL6 gene promoter:
         FOXF2   LCR-F1   Tal-1beta   RORalpha2   MEF-2A   POU2F1   IRF-7A   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSBPL6 promoter sequence
   Search Chromatin IP Primers for OSBPL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBPL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q31.2   HGNC cytogenetic band: 2q32.1

OSBPL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P179023:  view genomic region     (about GC identifiers)

Start:
179,059,208 bp from pter      End:
179,264,160 bp from pter
Size:
204,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OSBL6_HUMAN, Q9BZF3 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 6  
Size: 934 amino acids; 106306 Da
Sequence caution: Sequence=BAB55223.1; Type=Erroneous initiation; Sequence=BAD92135.1; Type=Erroneous initiation;
Secondary accessions: B4DTW1 C4AMC0 C4AME4 D3DPF6 D3DPF7 Q4ZG68 Q53T68 Q59H61 Q7Z4Q1 Q8N9T0
Q96SR1
Alternative splicing: 5 isoforms:  Q9BZF3-1   Q9BZF3-2   Q9BZF3-3   Q9BZF3-4   Q9BZF3-5   

Explore the universe of human proteins at neXtProt for OSBPL6: NX_Q9BZF3

Explore proteomics data for OSBPL6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSBPL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001188409.1  NP_001188410.1  NP_001188411.1  NP_115912.1  NP_665682.1  

    ENSEMBL proteins: 
     ENSP00000376293   ENSP00000349591   ENSP00000387248   ENSP00000190611   ENSP00000386885  
     ENSP00000318723   ENSP00000352713  

    OSBPL6 Human Recombinant Protein Products:

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    Novus Biologicals OSBPL6 Proteins
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OSBP: Oxysterol binding proteins

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q9BZF3

    ProtoNet protein and cluster: Q9BZF3

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBL6_HUMAN, Q9BZF3
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    OSBPL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008289lipid binding IEA--
         
    OSBPL6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OSBPL6
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    miRNA
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    miRTarBase miRNAs that target OSBPL6:
    hsa-mir-192-5p (MIRT026268), hsa-mir-215-5p (MIRT024344)

    Block miRNA regulation of human, mouse, rat OSBPL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL6 (see all 87):
    hsa-miR-140-5p hsa-miR-200a hsa-miR-519a hsa-miR-3150b-3p hsa-miR-4325 hsa-miR-3148 hsa-miR-130b hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL6

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    GenScript: all cDNA clones in your preferred vector (see all 5): OSBPL6 (NM_001201482)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum4
    nucleus4
    plasma membrane4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA14593528
    GO:0005886plasma membrane IDA14593528
    GO:0031965nuclear membrane IDA14593528
    GO:0097038perinuclear endoplasmic reticulum IDA14593528

    OSBPL6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBPL6
    Interactions:

        Search GeneGlobe Interaction Network for OSBPL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for OSBPL6 (Q9BZF31, 3 ENSP000003187234) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    SPATA5ENSP000002740084STRING: ENSP00000274008
    LACE1ENSP000003579734STRING: ENSP00000357973
    OSBPL5ENSP000002636504STRING: ENSP00000263650
    OSBPL8ENSP000002611834STRING: ENSP00000261183
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    OSBPL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBPL6 (OSBL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OSBPL6 gene (5 alternative transcripts): 
    NM_001201480.1  NM_001201481.1  NM_001201482.1  NM_032523.3  NM_145739.2  

    Unigene Cluster for OSBPL6:

    Oxysterol binding protein-like 6
    Hs.318775  [show with all ESTs]
    Unigene Representative Sequence: NM_001201480
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392505 ENST00000477646 ENST00000357080(uc002ulw.3) ENST00000409045
    ENST00000190611(uc002uly.3 uc002ulx.3 uc010zfe.2 uc002ulz.3 uc002uma.3)
    ENST00000409631 ENST00000315022 ENST00000477097 ENST00000359685
    miRNA
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    Block miRNA regulation of human, mouse, rat OSBPL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL6 (see all 87):
    hsa-miR-140-5p hsa-miR-200a hsa-miR-519a hsa-miR-3150b-3p hsa-miR-4325 hsa-miR-3148 hsa-miR-130b hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSBPL6
    Predesigned siRNA for gene silencing in human, mouse, rat OSBPL6
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    OriGene clones in human, mouse for OSBPL6 (see all 12)
    OriGene ORF clones in mouse, rat for OSBPL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): OSBPL6 (NM_001201482)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OSBPL6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL6
      QuantiTect SYBR Green Assays in human, mouse, rat OSBPL6
      QuantiFast Probe-based Assays in human, mouse, rat OSBPL6

    Additional mRNA sequence: 

    AB208898.1 AF323728.1 AF392448.1 AF462443.1 AK027600.1 AK093902.1 AK123248.1 AK300389.1 
    BC052259.1 

    10 DOTS entries:

    DT.40267649  DT.121024106  DT.91825177  DT.303228  DT.100021622  DT.100731042  DT.75198402  DT.100740357 
    DT.75176792  DT.97802844 

    Selected AceView cDNA sequences (see all 82):

    BG574529 BM671369 Z38437 BM692807 NM_032523 AI821149 BG654741 BX647557 
    BM129830 AI760493 BX504092 CA311529 BC052259 AF462443 CA425863 BU674714 
    AW204786 AK123248 BM975406 NM_145739 F10997 BM693956 BM663950 BM129618 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL6 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:                                -                 -                                                                                         -               
    SP2:                                                  -                                                                                         -               
    SP3:                                -                 -                                         -                                               -               
    SP4:                                -                 -                                         -                             -                 -               
    SP5:                                -                 -                                   -     -                             -                                 

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for OSBPL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSBPL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTAAGAAA
    OSBPL6 Expression
    About this image


    OSBPL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Kidney (Urinary System)
    OSBPL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBPL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.318775

    UniProtKB/Swiss-Prot: OSBL6_HUMAN, Q9BZF3
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBPL6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbpl61 , 5 oxysterol binding protein-like 61, 5 89.99(n)1
    97.81(a)1
      2 (44.94 cM)5
    990311  NM_145525.21  NP_663500.21 
     764065085 
    chicken
    (Gallus gallus)
    Aves OSBPL61 oxysterol binding protein-like 6 82.33(n)
    90.99(a)
      424130  XM_004942706.1  XP_004942763.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL66
    oxysterol binding protein-like 6
    89(a)
    1 ↔ 1
    GL343320.1(1155734-1291393)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia osbpl61 oxysterol binding protein-like 6 78.16(n)
    86.14(a)
      734134  XM_002935685.2  XP_002935731.2 
    zebrafish
    (Danio rerio)
    Actinopterygii osbpl61 oxysterol binding protein-like 6 71.75(n)
    78.61(a)
      100004342  NM_001127405.1  NP_001120877.1 
    rice
    (Oryza sativa)
    Liliopsida AK065804.12   -- 74.35(n)    AK065804.1 


    ENSEMBL Gene Tree for OSBPL6 (if available)
    TreeFam Gene Tree for OSBPL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSBPL6 gene
    OSBPL1A2  OSBP2  OSBPL32  OSBPL72  OSBP22  OSBPL22  
    2 SIMAP similar genes for OSBPL6 using alignment to 5 protein entries:     OSBL6_HUMAN (see all proteins):
    OSBPL3    OSBPL7

    OSBPL6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSBPL6 (see all 4064)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340460941,2
    C--171025254(+) TACTA-/GAACTTGG 4 -- int11Minor allele frequency- GAA:0.00NA 2
    rs607626661,2
    C--178571262(+) ATATA-/TATAT 
     ATATATA
    GAATA
    4 -- int11Minor allele frequency- TATATATATATA:0.00NA 2
    rs1908692891,2
    --179057232(+) AATCAA/GTGAGA 4 -- us2k10--------
    rs1840693651,2
    --179057262(+) CCTGAC/TGTTTA 4 -- us2k10--------
    rs718376681,2
    C--179057452(+) TTTTT-/TTTTTTTT 4 -- cds10--------
    rs729619971,2
    C--179057452(+) TCTTTT/CTTTTT 4 -- us2k14Minor allele frequency- C:0.12NA 8
    rs2006934721,2
    --179057452(+) TCTTT-/CTTTTT 4 -- us2k10--------
    rs351398291,2
    C--179057467(+) TTTTT-/T/T   
       T
    /TTT
    GAGAG
    8 -- us2k1 cds11NA 2
    rs1152648731,2
    F--179057472(+) TGAGAG/ATCTCA 4 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1886476321,2
    C--179057619(+) GCCACC/GACACC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSBPL6 (179059208 - 179264160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OSBPL6 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662653CNV Deletion23128226
    esv268453CNV Insertion20981092
    nsv3056CNV Insertion18451855
    nsv3057CNV Insertion18451855
    esv274681CNV Insertion20981092
    esv21696CNV Loss19812545
    dgv4371n71CNV Loss21882294
    nsv834467CNV Loss17160897
    nsv875452CNV Gain21882294
    nsv834466CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606734    OMIM disorders: --

    2 diseases for OSBPL6:    
    About MalaCards
    pulmonary function    breast cancer


    OSBPL6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OSBPL6
    Human Genome Epidemiology (HuGE) Navigator: OSBPL6 (1 document)

    Export disorders for OSBPL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSBPL6 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with OSBPL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2, 3 Lehto M.... Olkkonen V.M. (J. Lipid Res. 2001)
    2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (Genomics 2001)
    5. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PubMed id 14593528)1, 9 Lehto M....Olkkonen V.M. (Cell Tissue Res. 2004)
    6. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PubMed id 10588946)1, 9 Laitinen S....Ikonen E. (J. Lipid Res. 1999)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Genetic variants associated with breast size also influence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (BMC Med. Genet. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Impact of ancestry and common genetic variants on QT interval in African Americans. (PubMed id 23166209)1 Smith J.G....Newton-Cheh C. (Circ Cardiovasc Genet 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 114880 HGNC: 16388 AceView: OSBPL6 Ensembl:ENSG00000079156 euGenes: HUgn114880
    ECgene: OSBPL6 H-InvDB: OSBPL6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OSBPL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OSBPL6 gene:
    Search GeneIP for patents involving OSBPL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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