Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OSBPL5 Gene

protein-coding GIFtS: 57
GCID: GC11M003108

oxysterol binding protein-like 5

Explore 8 diseases affiliated with
OSBPL5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oxysterol Binding Protein-Like 5¹ ²		OSBP-Related Protein 5² ³
ORP5¹ ² ³ ⁵		Oxysterol-Binding Protein Homologue 1²
KIAA1534¹ ³ ⁵		Oxysterol-Binding Protein-Related Protein 5²
Oxysterol-Binding Protein Homolog 1² ³		EC 1.2.1⁸
OBPH1² ³		EC 2.7.7.6⁸
ORP-5² ³

External Ids:	HGNC: 16392¹	Entrez Gene: 114879²	Ensembl: ENSG00000021762⁷	OMIM: 606733⁵	UniProtKB: Q9H0X9³

Export aliases for OSBPL5 gene to outside databases

Previous GC identifers: GC11M003167 GC11M003359 GC11M003072 GC11M003064 GC11M002896

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSBPL5:

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors

that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal

pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown

to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding

different isoforms have been identified. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: OSBL5_HUMAN, Q9H0X9

Function: May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes

Gene Wiki entry for OSBPL5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OSBPL5 gene promoter:
FOXO3b C/EBPalpha NF-AT N-Myc FAC1 NF-AT4 NF-AT2 FOXO4 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OSBPL5 promoter sequence

Search SABiosciences Chromatin IP Primers for OSBPL5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

OSBPL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL5 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M003108: view genomic region (about GC identifiers)

Start:	3,108,346 bp from pter	End:	3,187,969 bp from pter
Size:	79,624 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSBL5_HUMAN, Q9H0X9 (See protein sequence)

Recommended Name: Oxysterol-binding protein-related protein 5

Size: 879 amino acids; 98616 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein

Miscellaneous: The gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only.

Not imprinted in other tissues

Sequence caution: Sequence=BAA96058.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the N-terminal part;

Secondary accessions: A6NDP0 A6NJS8 Q54A90 Q8N596 Q9BZB0 Q9P1Z4

Alternative splicing: 2 isoforms: Q9H0X9-1 Q9H0X9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OSBPL5: NX_Q9H0X9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H0X9

2 DME Specific Peptides for OSBPL5 (Q9H0X9)

TLELGGK

AVKGPKG

OSBPL5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001137535.1 NP_065947.1 NP_663613.1

ENSEMBL proteins:

ENSP00000437141 ENSP00000263650 ENSP00000374639 ENSP00000431412 ENSP00000433342

ENSP00000434265 ENSP00000302872 ENSP00000436950 ENSP00000433754 ENSP00000435812

ENSP00000432507 ENSP00000433222 ENSP00000441551

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: OSBPL5 OriGene Protein Over-expression Lysate (see all 2): OSBPL5 OriGene Custom Protein Services for OSBPL5
	GenScript Custom Purified and Recombinant Proteins Services for OSBPL5
	Novus Biologicals OSBPL5 Protein Novus Biologicals OSBPL5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OSBPL5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	NAS	10588946
GO:0016021	integral to membrane	IEA	--

OSBPL5 for ontologies About GeneDecksing

OSBPL5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: OSBPL5 OriGene Custom Antibody Services for OSBPL5
	GenScript Custom Superior Antibodies Services for OSBPL5
	Novus Biologicals OSBPL5 Antibodies
	Search for Antibodies for OSBPL5 at Abcam
	Uscn Antibodies for OSBPL5
	ThermoFisher Antibodies for OSBPL5

Assay Products for OSBPL5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OSBPL5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OSBPL5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OSBPL5 for domains About GeneDecksing

4 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR000648 Oxysterol-bd

IPR018494 Oxysterol-bd_CS

Graphical View of Domain Structure for InterPro Entry Q9H0X9

ProtoNet protein and cluster: Q9H0X9

2 Blocks protein families:

IPB000648 Oxysterol-binding protein

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: OSBL5_HUMAN, Q9H0X9

Similarity: Belongs to the OSBP family

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OSBL5_HUMAN, Q9H0X9

Function: May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes

Enzyme Numbers (IUBMB): EC 1.2.1² EC 2.7.7.6²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): OSBPL5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBPL5
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBPL5 (see all 31):
		hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-661

		SwitchGear 3'UTR luciferase reporter plasmid: OSBPL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBPL5 (see all 7) OriGene shRNA RFP: OSBPL5 OriGene siRNA: OSBPL5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBPL5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for OSBPL5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): OSBPL5 (NM_020896)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OSBPL5
		Search LifeMap BioReagents cell lines for OSBPL5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005543	phospholipid binding	IEA	--
GO:0008142	oxysterol binding	NAS	10588946
GO:0015485	cholesterol binding	IDA	17428193

OSBPL5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for OSBPL5:

Decreased homologous recombina

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OSBPL5

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for OSBPL5 (Q9H0X9³ ENSP00000263650⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519³, ENSP00000361423⁴	I2D: score=2 STRING: ENSP00000361423
NPC1	O15118³, ENSP00000269228⁴	I2D: score=1 STRING: ENSP00000269228
HGS	O14964³, ENSP00000331201⁴	I2D: score=1 STRING: ENSP00000331201
SQSTM1	Q13501³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	--	--
GO:0006893	Golgi to plasma membrane transport	NAS	10588946
GO:0008203	cholesterol metabolic process	NAS	10588946
GO:0030301	cholesterol transport	NAS	10588946

OSBPL5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OSBPL5
Search CenterWatch for drugs/clinical trials and news about OSBPL5 / OSBL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OSBPL5 gene (3 alternative transcripts):

NM_001144063.1 NM_020896.3 NM_145638.2

Unigene Cluster for OSBPL5:

Oxysterol binding protein-like 5

Hs.436166 [show with all ESTs]

Unigene Representative Sequence: NM_020896

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000478260(uc001lxj.2) ENST00000263650(uc010qxq.1 uc001lxk.2 uc009ydw.2 uc001lxl.2)

ENST00000389989 ENST00000534454 ENST00000498536 ENST00000525498 ENST00000471998

ENST00000348039 ENST00000534491(uc009ydx.3) ENST00000532951 ENST00000459995

ENST00000533234 ENST00000465323 ENST00000477622 ENST00000526122(uc001lxm.1)

ENST00000530372 ENST00000533721 ENST00000534157

miRNA Products:		OriGene 3'-UTR Clone (see all 3): OSBPL5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBPL5
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBPL5 (see all 31):
		hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-661

		SwitchGear 3'UTR luciferase reporter plasmid: OSBPL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBPL5 (see all 7) OriGene shRNA RFP: OSBPL5 OriGene siRNA: OSBPL5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBPL5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): OSBPL5 (NM_020896)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBPL5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSBPL5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL5

Additional cDNA sequence:

AB074006.1 AF392453.1 AF410430.1 AK055617.1 AK056510.1 AK124919.1 AK293000.1 AK297475.1

AK301003.1 AK303205.1 AK309411.1 AL136918.1 BC017505.1 BC032646.1 BC039579.1

8 DOTS entries:

DT.111257 DT.97864131 DT.101960341 DT.95371871 DT.75160483 DT.120713661 DT.91857490 DT.120713673

24/117 AceView cDNA sequences (see all 117):

AL526548 CA393707 CR617583 AA463521 BM676569 AA835809 CB961321 CR619585

BI035888 BF436549 CR593884 BQ933320 BU730568 BM705476 CR598808 BM463634

BX386681 CA311223 AW276049 BX325687 BC017505 CA444836 AF331964 BG751177

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL5 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14	^
SP1:											-		-		-		-		-		-						-										-
SP2:									-		-		-		-		-		-		-						-										-		-		-
SP3:
SP4:											-		-		-		-		-		-						-										-		-		-
SP5:											-		-		-		-		-		-						-										-

ExUns:	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b
SP1:											-												-
SP2:											-												-
SP3:																							-
SP4:
SP5:

ECgene alternative splicing isoforms for OSBPL5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OSBPL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGATGGAT

About this image

OSBPL5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OSBPL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSBPL5

SOURCE GeneReport for Unigene cluster: Hs.436166

UniProtKB/Swiss-Prot: OSBL5_HUMAN, Q9H0X9

Tissue specificity: Ubiquitously expressed

SABiosciences Expression via Pathway-Focused PCR Array including OSBPL5:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OSBPL5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSBPL5 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	OSBPL5¹	oxysterol binding protein-like 5	69.9(n) 73.26(a)		770816 XM_001234138.2 XP_001234139.2
lizard (Anolis carolinensis)	Reptilia	--	--	68(a)	1 ↔ 1	1(68488603-68526061)
zebrafish (Danio rerio)	Actinopterygii	osbpl5¹	oxysterol binding protein-like 5	63.64(n) 61.23(a)		100006189 XM_001344986.4 XP_001345022.3
fruit fly (Drosophila melanogaster)	Insecta	CG5077³	oxysterol binding	51(a)		92E2 --
worm (Caenorhabditis elegans)	Secernentea	obr-3⁶	Oxysterol Binding protein (OSBP) Related family me...	43(a)	1 → many	X(13798247-13809789)
thale cress (Arabidopsis thaliana)	eudicotyledons	ORP4B¹	OSBP(oxysterol binding protein)-related protein 4B	45.1(n) 34.06(a)		828691 NM_001203913.1 NP_001190842.1
rice (Oryza sativa)	Liliopsida	Os08g0517700¹	hypothetical protein	45.86(n) 31.36(a)		4346042 NM_001068780.1 NP_001062245.1

ENSEMBL Gene Tree for OSBPL5 (if available)
TreeFam Gene Tree for OSBPL5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OSBPL5 gene

OSBPL10² OSBPL9² OSBPL11² OSBPL8²

4 SIMAP similar genes for OSBPL5 using alignment to 11 protein entries: OSBL5_HUMAN (see all proteins):

pp14733 OSBPL8 DKFZp686C0249 OSBPL9

OSBPL5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3888978^1,2	C	--	2942330(+)	`acccaC/Tccatt`	1	--	int¹		0	--	--	--	--
rs190307379^1,2		--	3108044(+)	`AGCCAA/GGGGGG`	3	--	ds500¹		0	--	--	--	--
rs182531184^1,2		--	3108071(+)	`GGCAGC/TATTGG`	3	--	ds500¹		0	--	--	--	--
rs61870195^1,2		--	3108142(+)	`AGTGTC/TACTCT`	3	--	ds500¹		1		NA	2
rs148998006^1,2		--	3108180(+)	`GGGACA/GCCAGC`	3	--	ds500¹		0	--	--	--	--
rs117344132^1,2		--	3108185(+)	`GCCAGC/TCTCCC`	3	--	ds500¹		1		NA	120
rs3741357^1,2	C,F,H,	--	3108222(-)	`GCTGTG/AGGCAG`	3	--	ds500¹		5		EA NS	1918
rs138281722^1,2		--	3108325(+)	`CCTCTC/TGTTTC`	3	--	ds500¹		0	--	--	--	--
rs8813^1,2	C,F,O,H,	--	3108506(-)	`NNNNAC/TGTACA`	3	--	ut3¹ ese³		20		MN NS EA NA	2572
rs143876464^1,2		--	3108514(+)	`TATATA/TTGTGT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OSBPL5 (3108346 - 3187969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for OSBPL5
9 CNVs: 75515 85613 85608 75516 85610 85609 75514 31795 85612
2 Indels: 85611 41684

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL5

DNA2.0 Custom Variant and Variant Library Synthesis for OSBPL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OSBPL5 for disorders           About GeneDecksing

OMIM gene information: 606733    OMIM disorders: --

8 diseases for OSBPL5:    About MalaCards

cholesterol alcohol dependence alcoholism pharyngitis

pancreatic cancer pancreatitis malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for OSBPL5:

ADULT syndrome

Human Genome Epidemiology (HuGE) Navigator: OSBPL5 (1 document)

Export disorders for OSBPL5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OSBPL5 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with OSBPL5)

Utopia: connect your pdf to the dynamic
world of online information

A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. (PubMed id 21220512)^{1, 2} Du X....Yang H. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse. (PubMed id 12504849)^{1, 2} Higashimoto K.... Mukai T. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)^{1, 2} Jaworski C.J.... Rodriguez I.R. (2001)
The OSBP-related protein family in humans. (PubMed id 11483621)^{1, 2} Lehto M.... Olkkonen V.M. (2001)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
Oxysterol binding protein-related protein-5 is related to invasion and poor prognosis in pancreatic cancer. (PubMed id 19032366)^{1, 9} Koga Y....Baba H. (2008)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114879	HGNC: 16392	AceView: OSBPL5	Ensembl:ENSG00000021762	euGenes: HUgn114879
ECgene: OSBPL5	H-InvDB: OSBPL5

(According to HUGE)
About This Section

HUGE: KIAA1534

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OSBPL5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OSBPL5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OSBPL5 gene:
Search GeneIP for patents involving OSBPL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for OSBPL5		OriGene shRNA RFP for OSBPL5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBPL5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL5
	OriGene Protein Over-expression Lysate for OSBPL5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for OSBPL5		OriGene 3'-UTR Clone for OSBPL5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for OSBPL5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for OSBPL5		OriGene Custom Protein Services for OSBPL5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSBPL5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBPL5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL5

	GenScript Custom Purified and Recombinant Proteins Services for OSBPL5		GenScript cDNA clones with any tag delivered in your preferred vector for OSBPL5
	GenScript Custom Assay Services for OSBPL5		GenScript Custom Superior Antibodies Services for OSBPL5
	GenScript Custom overexpressing Cell Line Services for OSBPL5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in OSBPL5 promoter
	Search Chromatin IP Primers for OSBPL5
	RT² qPCR Primer Assay in human, mouse, rat OSBPL5
	Search GNC Networks for OSBPL5
	SABiosciences PCR Arrays including human, mouse, rat OSBPL5

Search Tocris compounds for OSBPL5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	OSBPL5 antibodies
	OSBPL5 proteins
	OSBPL5 lysates

	Search for Antibodies for OSBPL5 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for OSBPL5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

OSBPL5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for OSBPL5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL5

	SwitchGear 3'UTR luciferase reporter plasmids for OSBPL5
	SwitchGear Promoter luciferase reporter plasmids for OSBPL5

ThermoFisher Antibodies for OSBPL5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OSBPL5 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

OSBPL5 Gene

oxysterol binding protein-like 5

Aliases
for OSBPL5 gene

Summaries
for OSBPL5 gene

Genomic Views
for OSBPL5 gene

Proteins
for OSBPL5 gene

Protein Domains /
Families
for OSBPL5 gene

Function
for OSBPL5 gene

Pathways & Interactions
for OSBPL5 gene

Drugs & Compounds
for OSBPL5 gene

Transcripts
for OSBPL5 gene

Expression
for OSBPL5 gene

Orthologs
for OSBPL5 gene

Paralogs
for OSBPL5 gene

Genomic Variants
for OSBPL5 gene

Disorders / Diseases
for OSBPL5 gene

Publications
for OSBPL5 gene

External Searches for OSBPL5 gene

Genome Databases showing OSBPL5 gene

Other Databases showing OSBPL5 gene

Specialized Databases showing OSBPL5 gene

Intellectual Property
for OSBPL5 gene

Products
for OSBPL5 gene

View Random Gene

Advanced Search

Export list of displayed genes

OSBPL5 Gene

oxysterol binding protein-like 5

Aliasesfor OSBPL5 gene

Summariesfor OSBPL5 gene

Genomic Viewsfor OSBPL5 gene

Proteinsfor OSBPL5 gene

Protein Domains /Familiesfor OSBPL5 gene

Functionfor OSBPL5 gene

Pathways & Interactionsfor OSBPL5 gene

Drugs & Compoundsfor OSBPL5 gene

Transcriptsfor OSBPL5 gene

Expression for OSBPL5 gene

Orthologsfor OSBPL5 gene

Paralogsfor OSBPL5 gene

Genomic Variantsfor OSBPL5 gene

Disorders / Diseasesfor OSBPL5 gene

Publicationsfor OSBPL5 gene

External Searches for OSBPL5 gene

Genome Databases showing OSBPL5 gene

Other Databases showing OSBPL5 gene

Specialized Databases showing OSBPL5 gene

Intellectual Propertyfor OSBPL5 gene

Productsfor OSBPL5 gene

View Random Gene

Aliases
for OSBPL5 gene

Summaries
for OSBPL5 gene

Genomic Views
for OSBPL5 gene

Proteins
for OSBPL5 gene

Protein Domains /
Families
for OSBPL5 gene

Function
for OSBPL5 gene

Pathways & Interactions
for OSBPL5 gene

Drugs & Compounds
for OSBPL5 gene

Transcripts
for OSBPL5 gene

Expression
for OSBPL5 gene

Orthologs
for OSBPL5 gene

Paralogs
for OSBPL5 gene

Genomic Variants
for OSBPL5 gene

Disorders / Diseases
for OSBPL5 gene

Publications
for OSBPL5 gene

Intellectual Property
for OSBPL5 gene

Products
for OSBPL5 gene