Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSBPL3 Gene

Aliases for OSBPL3 Gene

  • Oxysterol Binding Protein-Like 3 2 3
  • ORP3 3 4 6
  • OSBP-Related Protein 3 3 4
  • KIAA0704 4 6
  • OSBP3 3 4
  • ORP-3 3 4
  • Oxysterol-Binding Protein-Related Protein 3 3

External Ids for OSBPL3 Gene

Previous Symbols for OSBPL3 Gene

  • OSBP3

Summaries for OSBPL3 Gene

Entrez Gene Summary for OSBPL3 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for OSBPL3 Gene

OSBPL3 (Oxysterol Binding Protein-Like 3) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBP.

Gene Wiki entry for OSBPL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL3 Gene

Genomics for OSBPL3 Gene

Genomic Location for OSBPL3 Gene

24,796,537 bp from pter
24,981,634 bp from pter
185,098 bases
Minus strand

Genomic View for OSBPL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL3 Gene

Regulatory Elements for OSBPL3 Gene

Proteins for OSBPL3 Gene

  • Protein details for OSBPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D167
    • A4D168
    • A4D169
    • A4D170
    • A4D171
    • A4D172
    • B8ZZ79
    • B8ZZP0
    • O14591
    • O43357
    • O43358
    • Q8N702
    • Q8N703
    • Q8N704
    • Q8NFH0
    • Q8NFH1
    • Q8NI12
    • Q8NI13
    • Q9BZF4
    • Q9UED6

    Protein attributes for OSBPL3 Gene

    887 amino acids
    Molecular mass:
    101224 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31679.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL3 Gene

neXtProt entry for OSBPL3 Gene

Proteomics data for OSBPL3 Gene at MOPED

Post-translational modifications for OSBPL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55

No data available for DME Specific Peptides for OSBPL3 Gene

Domains for OSBPL3 Gene

Gene Families for OSBPL3 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBPL3 Gene

Suggested Antigen Peptide Sequences for OSBPL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.:
    • Q9H4L5
  • Belongs to the OSBP family.:
    • Q9H4L5
genes like me logo Genes that share domains with OSBPL3: view

Function for OSBPL3 Gene

Gene Ontology (GO) - Molecular Function for OSBPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL3: view

miRNA for OSBPL3 Gene

miRTarBase miRNAs that target OSBPL3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL3 Gene

Localization for OSBPL3 Gene

Subcellular locations from

Jensen Localization Image for OSBPL3 Gene COMPARTMENTS Subcellular localization image for OSBPL3 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OSBPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14593528
GO:0005886 plasma membrane IDA 14593528
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IDA 14593528
GO:0097038 perinuclear endoplasmic reticulum IDA 14593528
genes like me logo Genes that share ontologies with OSBPL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSBPL3 Gene

Pathways for OSBPL3 Gene

SuperPathways for OSBPL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL3: view

No data available for Pathways by source for OSBPL3 Gene

Transcripts for OSBPL3 Gene

Unigene Clusters for OSBPL3 Gene

Oxysterol binding protein-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ·
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP6: -
SP11: - - - -

ExUns: 19c · 19d ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b
SP5: -
SP8: - - -

Relevant External Links for OSBPL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL3 Gene

mRNA expression in normal human tissues for OSBPL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL3 Gene

SOURCE GeneReport for Unigene cluster for OSBPL3 Gene Hs.520259

mRNA Expression by UniProt/SwissProt for OSBPL3 Gene

Tissue specificity: Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung
genes like me logo Genes that share expressions with OSBPL3: view

No data available for mRNA differential expression in normal tissues for OSBPL3 Gene

Orthologs for OSBPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSBPL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSBPL3 35
  • 99.44 (n)
  • 99.77 (a)
  • 100 (a)
(Bos Taurus)
Mammalia OSBPL3 35
  • 90.82 (n)
  • 93.34 (a)
  • 88 (a)
(Canis familiaris)
Mammalia OSBPL3 35
  • 90.68 (n)
  • 94.25 (a)
  • 92 (a)
(Mus musculus)
Mammalia Osbpl3 35
  • 85.89 (n)
  • 91.46 (a)
Osbpl3 16
Osbpl3 36
  • 91 (a)
(Monodelphis domestica)
Mammalia OSBPL3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia OSBPL3 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Osbpl3 35
  • 86.27 (n)
  • 91.31 (a)
(Gallus gallus)
Aves OSBPL3 35
  • 76.41 (n)
  • 80.14 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia OSBPL3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl3 35
  • 71.32 (n)
  • 72.93 (a)
(Danio rerio)
Actinopterygii Dr.24867 35
OSBPL3 (2 of 2) 36
  • 65 (a)
osbpl3a 36
  • 52 (a)
si:dkey-15j7.2 35
  • 65.19 (n)
  • 65.68 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ORP1B 35
  • 52.82 (n)
  • 45.48 (a)
(Oryza sativa)
Liliopsida Os.35068 35
Os03g0704700 35
  • 53.18 (n)
  • 46.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 36
  • 36 (a)
Species with no ortholog for OSBPL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL3 Gene

Gene Tree for OSBPL3 (if available)
Gene Tree for OSBPL3 (if available)

Paralogs for OSBPL3 Gene

Paralogs for OSBPL3 Gene

Selected SIMAP similar genes for OSBPL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSBPL3: view

Variants for OSBPL3 Gene

Sequence variations from dbSNP and Humsavar for OSBPL3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs114 -- 24,927,227(+) GGGGA(A/G)TTGAC intron-variant
rs115 -- 24,927,136(+) TATGT(A/C)TGGAA intron-variant
rs116 -- 24,925,679(+) TTTCA(C/T)CGCTT intron-variant
rs117 -- 24,924,437(+) AGAGT(C/T)TAACT intron-variant
rs118 -- 24,924,295(+) GAGGC(C/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL3 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv520276 CNV Gain 19592680
nsv5667 CNV Insertion 18451855
esv24690 CNV Loss 19812545
esv994994 CNV Insertion 20482838

Relevant External Links for OSBPL3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL3 Gene

Disorders for OSBPL3 Gene

Relevant External Links for OSBPL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OSBPL3: view

No data available for UniProtKB/Swiss-Prot for OSBPL3 Gene

Publications for OSBPL3 Gene

  1. ORP3 splice variants and their expression in human tissues and hematopoietic cells. (PMID: 12590732) Collier F.M. … Kirkland M.A. (DNA Cell Biol. 2003) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M. … Olkkonen V.M. (Cell Tissue Res. 2004) 3 23

Products for OSBPL3 Gene

Sources for OSBPL3 Gene

Back to Top