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OSBPL2 Gene

protein-coding   GIFtS: 56
GCID: GC20P060813

Oxysterol Binding Protein-Like 2

(Previous name: oxysterol-binding protein-like 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxysterol Binding Protein-Like 21 2     OSBP-Related Protein 22 3
ORP22 3 5     KIAA07723 5
Oxysterol-Binding Protein-Like 21 2     Oxysterol-Binding Protein-Related Protein 22
ORP-22 3     

External Ids:    HGNC: 157611   Entrez Gene: 98852   Ensembl: ENSG000001307037   OMIM: 6067315   UniProtKB: Q9H1P33   

Export aliases for OSBPL2 gene to outside databases

Previous GC identifers: GC20P060577 GC20P061450 GC20P061498 GC20P060246 GC20P057589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSBPL2 Gene:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid
receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal
OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded
protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind
strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to
25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different
isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for OSBPL2 Gene:
OSBPL2 (oxysterol binding protein-like 2) is a protein-coding gene. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBPL1A.

UniProtKB/Swiss-Prot: OSBL2_HUMAN, Q9H1P3
Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to
phosphatidylinositol 3-phosphate

Gene Wiki entry for OSBPL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBPL2 gene promoter:
         ER-alpha   USF1   HTF   Olf-1   CBF-C   C/EBPalpha   Arnt   CBF-A   USF-1   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OSBPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

OSBPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBPL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060813:  view genomic region     (about GC identifiers)

Start:
60,813,580 bp from pter      End:
60,871,269 bp from pter
Size:
57,690 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSBL2_HUMAN, Q9H1P3 (See protein sequence)
Recommended Name: Oxysterol-binding protein-related protein 2  
Size: 480 amino acids; 55201 Da
Sequence caution: Sequence=BAA34492.2; Type=Erroneous initiation;
Secondary accessions: A8K736 Q6IBT0 Q9BZB1 Q9Y4B8
Alternative splicing: 2 isoforms:  Q9H1P3-1   Q9H1P3-2   

Explore the universe of human proteins at neXtProt for OSBPL2: NX_Q9H1P3

Explore proteomics data for OSBPL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys209
  • Modification sites at PhosphoSitePlus

  • See OSBPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265578.1  NP_055650.1  NP_653081.1  

    ENSEMBL proteins: 
     ENSP00000350755   ENSP00000316649   ENSP00000415751   ENSP00000397602  

    OSBPL2 Human Recombinant Protein Products:

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    Novus Biologicals OSBPL2 Protein
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    Cloud-Clone Corp. Proteins for OSBPL2

     
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    antibodies-online proteins for OSBPL2 (2 products) 

     
    antibodies-online peptides for OSBPL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OSBP: Oxysterol binding proteins

    2 InterPro protein domains:
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q9H1P3

    ProtoNet protein and cluster: Q9H1P3

    UniProtKB/Swiss-Prot: OSBL2_HUMAN, Q9H1P3
    Similarity: Belongs to the OSBP family


    Find genes that share domains with OSBPL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSBL2_HUMAN, Q9H1P3
    Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to
    phosphatidylinositol 3-phosphate

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015485cholesterol binding IDA17428193
         
    Find genes that share ontologies with OSBPL2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OSBPL2

    miRNA
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    miRTarBase miRNAs that target OSBPL2:
    hsa-mir-92a-3p (MIRT049254)

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    Selected qRT-PCR Assays for microRNAs that regulate OSBPL2 (see all 28):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-549 hsa-miR-548i hsa-miR-4272 hsa-miR-3660 hsa-miR-1271 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBPL2
    Interactions:

        GeneGlobe Interaction Network for OSBPL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for OSBPL2 (ENSP000003166494) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    SPATA5ENSP000002740084STRING: ENSP00000274008
    LACE1ENSP000003579734STRING: ENSP00000357973
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    OSBPL8ENSP000002611834STRING: ENSP00000261183
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with OSBPL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBPL2 (OSBL2)

    Selected HMDB Compounds for OSBPL2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(9Z))PA(36:2) (see all 10)14268-17-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSBPL2 gene (3 alternative transcripts): 
    NM_001278649.1  NM_014835.3  NM_144498.2  

    Unigene Cluster for OSBPL2:

    Oxysterol binding protein-like 2
    Hs.473254  [show with all ESTs]
    Unigene Representative Sequence: NM_144498
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358053(uc002ycl.1 uc011aah.1) ENST00000313733(uc002yck.1)
    ENST00000448156 ENST00000471817 ENST00000439951(uc002ycm.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat OSBPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBPL2 (see all 28):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-549 hsa-miR-548i hsa-miR-4272 hsa-miR-3660 hsa-miR-1271 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidOSBPL2 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBPL2
      QuantiTect SYBR Green Assays in human, mouse, rat OSBPL2
      QuantiFast Probe-based Assays in human, mouse, rat OSBPL2

    Additional mRNA sequence: 

    AB018315.1 AF331963.1 AF392447.1 AK000230.1 AK093592.1 AK123598.1 AK124174.1 AK291851.1 
    AK296595.1 AK315576.1 AY028168.1 BC000296.2 BC004455.1 BC018812.2 CR456722.1 

    14 DOTS entries:

    DT.113773  DT.312433  DT.97844863  DT.91818559  DT.92438699  DT.95205665  DT.97819775  DT.100794694 
    DT.95299932  DT.100794692  DT.120813652  DT.120813680  DT.120813690  DT.95189817 

    Selected AceView cDNA sequences (see all 249):

    AI492555 BI829746 AI223219 AY028168 BM673225 BM712650 AI935875 AL574823 
    BQ437218 AW081922 NM_014835 CR594910 BQ021781 CF529172 BM768598 BX445450 
    BU957486 BU860050 BM982257 D17006 CA407825 AA885187 AW167999 AI868580 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12 ^ 13a · 13b ^ 14a · 14b ·
    SP1:                    -                 -                       -                             -     -                       -           -                     
    SP2:        -     -     -                 -                       -                             -     -                                                         
    SP3:                    -                 -                                                                                                                     
    SP4:                    -                 -     -     -           -                             -     -                                                         
    SP5:                    -                 -     -                 -                                                                                             

    ExUns: 14c ^ 15a · 15b ^ 16 ^ 17
    SP1:  -                           
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for OSBPL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSBPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTAACTTT
    OSBPL2 Expression
    About this image


    OSBPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    OSBPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473254

    UniProtKB/Swiss-Prot: OSBL2_HUMAN, Q9H1P3
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OSBPL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbpl21 , 5 oxysterol binding protein-like 21, 5 85.94(n)1
    90.19(a)1
      2 (102.64 cM)5
    2289831  NM_144500.31  NP_653083.21 
     1801193065 
    chicken
    (Gallus gallus)
    Aves OSBPL21 oxysterol binding protein-like 2 74.17(n)
    80.83(a)
      419227  NM_001008448.1  NP_001008448.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSBPL26
    oxysterol binding protein-like 2
    80(a)
    1 ↔ 1
    4(150893317-150962764)
    African clawed frog
    (Xenopus laevis)
    Amphibia osbpl2-prov2 oxysterol binding protein-like 2 74.39(n)    BC041743.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi36a042 wufi36a04 77.8(n)   334206  BC045502.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38603 oxysterol binding 48(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F14H8.13
    obr-21
    oxysterol-binding protein3
    obr-21
    32(a)3
    48.31(n)1
    39.74(a)1
      V(15014568-15016817)3
    1800031  NM_001129445.31  NP_001122917.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWH16
    OSH26
    Protein similar to mammalian oxysterol-binding pro...
    Member of an oxysterol-binding protein family with...
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    I(192619-196185) YAR042W
    IV(417663-421514) YDL019C


    ENSEMBL Gene Tree for OSBPL2 (if available)
    TreeFam Gene Tree for OSBPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSBPL2 gene
    OSBPL1A2  OSBP2  OSBPL32  OSBPL72  OSBP22  OSBPL62  
    5 SIMAP similar genes for OSBPL2 using alignment to 3 protein entries:     OSBL2_HUMAN (see all proteins):
    OSBPL1A    OSBP    OSBPL5    OSBP2    OSBPL7

    Find genes that share paralogs with OSBPL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSBPL2 (see all 1479)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891952671,2
    C--60811864(+) GTCCTC/TGTCCT 2 -- us2k10--------
    rs1815218921,2
    --60811877(+) CTTGGC/GGGCCG 2 -- us2k10--------
    rs1859819771,2
    --60811923(+) TTTCTC/TCAGAG 2 -- us2k10--------
    rs1903070331,2
    --60811936(+) AACCAC/TGGCAA 2 -- us2k10--------
    rs37612271,2
    C--60812094(+) AGAACA/GGCCCT 2 -- us2k10--------
    rs790805321,2
    C,F--60812225(+) AAAGGC/TCTGTC 2 -- us2k11Minor allele frequency- T:0.07WA 118
    rs37612281,2
    C,F--60812240(+) CCTCCA/GTGGCC 2 -- us2k11Minor allele frequency- G:0.02EA 120
    rs37612291,2
    C,F--60812275(+) GGAGAC/TAAGGC 2 -- us2k10--------
    rs37612301,2
    C,F--60812279(+) ACAAGG/ACCTGA 2 -- us2k11Minor allele frequency- A:0.20EA 120
    rs1465724421,2
    C--60812307(+) CCAAC-/GGGGGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSBPL2 (60813580 - 60871269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OSBPL2 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722788CNV Deletion23290073
    dgv712e201CNV Deletion23290073
    esv2722791CNV Deletion23290073
    esv2722784CNV Deletion23290073
    esv2676247CNV Deletion23128226
    esv1677600CNV Deletion17803354
    esv2722786CNV Deletion23290073
    esv2671535CNV Deletion23128226
    esv2722790CNV Deletion23290073
    esv1770279CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606731    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for OSBPL2:
    Familial combined hyperlipidemia

    Find genes that share disorders with OSBPL2           About GenesLikeMe

    Genetic Association Database (GAD): OSBPL2
    Human Genome Epidemiology (HuGE) Navigator: OSBPL2 (4 documents)

    Export disorders for OSBPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSBPL2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with OSBPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. (PubMed id 11279184)1, 2, 9 Xu Y.... McMaster C.R. (J. Biol. Chem. 2001)
    2. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PubMed id 19554302)1, 4, 9 PerttilAo J....Olkkonen V.M. (J. Mol. Med. 2009)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. (PubMed id 11861666)1, 3 Laitinen S....Olkkonen V.M. (J. Lipid Res. 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (Genomics 2001)
    8. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (J. Lipid Res. 2001)
    9. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PubMed id 10588946)1, 3 Laitinen S....Ikonen E. (J. Lipid Res. 1999)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9885 HGNC: 15761 AceView: OSBPL2 Ensembl:ENSG00000130703 euGenes: HUgn9885
    ECgene: OSBPL2 H-InvDB: OSBPL2

    (According to HUGE)
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    HUGE: KIAA0772

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSBPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OSBPL2 gene:
    Search GeneIP for patents involving OSBPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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