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Aliases for OSBPL2 Gene

Aliases for OSBPL2 Gene

  • Oxysterol Binding Protein-Like 2 2 3
  • ORP2 3 4 6
  • Oxysterol-Binding Protein-Like 2 2 3
  • OSBP-Related Protein 2 3 4
  • KIAA0772 4 6
  • ORP-2 3 4
  • Oxysterol-Binding Protein-Related Protein 2 3
  • DFNA67 3

External Ids for OSBPL2 Gene

Previous GeneCards Identifiers for OSBPL2 Gene

  • GC20P060577
  • GC20P061450
  • GC20P061498
  • GC20P060246
  • GC20P060813
  • GC20P057589

Summaries for OSBPL2 Gene

Entrez Gene Summary for OSBPL2 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]

GeneCards Summary for OSBPL2 Gene

OSBPL2 (Oxysterol Binding Protein-Like 2) is a Protein Coding gene. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBP.

UniProtKB/Swiss-Prot for OSBPL2 Gene

  • Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate

Gene Wiki entry for OSBPL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL2 Gene

Genomics for OSBPL2 Gene

Regulatory Elements for OSBPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSBPL2 Gene

Start:
62,231,922 bp from pter
End:
62,296,213 bp from pter
Size:
64,292 bases
Orientation:
Plus strand

Genomic View for OSBPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL2 Gene

Proteins for OSBPL2 Gene

  • Protein details for OSBPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1P3-OSBL2_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 2
    Protein Accession:
    Q9H1P3
    Secondary Accessions:
    • A8K736
    • Q6IBT0
    • Q9BZB1
    • Q9Y4B8

    Protein attributes for OSBPL2 Gene

    Size:
    480 amino acids
    Molecular mass:
    55201 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34492.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL2 Gene

Proteomics data for OSBPL2 Gene at MOPED

Post-translational modifications for OSBPL2 Gene

  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

Other Protein References for OSBPL2 Gene

No data available for DME Specific Peptides for OSBPL2 Gene

Domains for OSBPL2 Gene

Gene Families for OSBPL2 Gene

HGNC:
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBPL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSBPL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1P3

UniProtKB/Swiss-Prot:

OSBL2_HUMAN :
  • Q9H1P3
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL2: view

Function for OSBPL2 Gene

Molecular function for OSBPL2 Gene

UniProtKB/Swiss-Prot Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate

Gene Ontology (GO) - Molecular Function for OSBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL2: view

Animal Model Products

CRISPR Products

miRNA for OSBPL2 Gene

miRTarBase miRNAs that target OSBPL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBPL2 Gene

Localization for OSBPL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL2 Gene COMPARTMENTS Subcellular localization image for OSBPL2 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OSBPL2 Gene

Pathways for OSBPL2 Gene

SuperPathways for OSBPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL2: view

No data available for Pathways by source for OSBPL2 Gene

Compounds for OSBPL2 Gene

(12) HMDB Compounds for OSBPL2 Gene

Compound Synonyms Cas Number PubMed IDs
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
PA(16:0e/18:0)
  • 2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
Not Available
genes like me logo Genes that share compounds with OSBPL2: view

Transcripts for OSBPL2 Gene

Unigene Clusters for OSBPL2 Gene

Oxysterol binding protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12 ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - -
SP6: - -
SP7: - -
SP8: -
SP9:
SP10: -
SP11:

ExUns: 14c ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for OSBPL2 Gene

GeneLoc Exon Structure for
OSBPL2
ECgene alternative splicing isoforms for
OSBPL2

Expression for OSBPL2 Gene

mRNA expression in normal human tissues for OSBPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL2 Gene

SOURCE GeneReport for Unigene cluster for OSBPL2 Gene Hs.473254

mRNA Expression by UniProt/SwissProt for OSBPL2 Gene

Q9H1P3-OSBL2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with OSBPL2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OSBPL2 Gene

Orthologs for OSBPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL2 35
  • 99.44 (n)
  • 99.79 (a)
OSBPL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL2 35
  • 85.82 (n)
  • 89.43 (a)
OSBPL2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl2 35
  • 85.94 (n)
  • 90.19 (a)
Osbpl2 16
Osbpl2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBPL2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl2 35
  • 85.04 (n)
  • 91.02 (a)
chicken
(Gallus gallus)
Aves OSBPL2 35
  • 74.17 (n)
  • 80.83 (a)
OSBPL2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL2 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia osbpl2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl2 35
  • 72.07 (n)
  • 74.95 (a)
zebrafish
(Danio rerio)
Actinopterygii osbpl2a 36
  • 69 (a)
OneToMany
osbpl2b 35
  • 70.2 (n)
  • 72.46 (a)
osbpl2b 36
  • 72 (a)
OneToMany
wufi36a04 35
fruit fly
(Drosophila melanogaster)
Insecta CG3860 36
  • 49 (a)
OneToMany
CG3860 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-2 35
  • 48.31 (n)
  • 39.74 (a)
obr-2 36
  • 36 (a)
OneToMany
F14H8.1 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH2 36
  • 12 (a)
ManyToMany
SWH1 36
  • 13 (a)
ManyToMany
Species with no ortholog for OSBPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBPL2 Gene

ENSEMBL:
Gene Tree for OSBPL2 (if available)
TreeFam:
Gene Tree for OSBPL2 (if available)

Paralogs for OSBPL2 Gene

Paralogs for OSBPL2 Gene

Selected SIMAP similar genes for OSBPL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OSBPL2: view

Variants for OSBPL2 Gene

Sequence variations from dbSNP and Humsavar for OSBPL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs944883 -- 62,246,494(-) ACACC(C/T)AGCTG intron-variant
rs944884 -- 62,245,742(-) ATCTG(C/G)AGCCC intron-variant
rs1537482 -- 62,269,773(-) AGCTC(C/G)GCACT intron-variant
rs2236524 -- 62,273,892(-) TAAAA(C/T)TCTGG intron-variant
rs2236525 -- 62,273,779(-) TTAGT(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL2 Gene

Variant ID Type Subtype PubMed ID
dgv4597n71 CNV Loss 21882294
dgv4599n71 CNV Loss 21882294
nsv913040 CNV Loss 21882294
dgv4600n71 CNV Loss 21882294
dgv4601n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
esv2722782 CNV Deletion 23290073
esv2722784 CNV Deletion 23290073
esv1770279 CNV Deletion 17803354
dgv712e201 CNV Deletion 23290073
esv2722786 CNV Deletion 23290073
esv2722788 CNV Deletion 23290073
nsv913048 CNV Loss 21882294
dgv4602n71 CNV Loss 21882294
esv2722789 CNV Deletion 23290073
esv2722790 CNV Deletion 23290073
esv1677600 CNV Deletion 17803354
esv2676247 CNV Deletion 23128226
esv2722791 CNV Deletion 23290073
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv913056 CNV Loss 21882294
esv2671535 CNV Deletion 23128226

Relevant External Links for OSBPL2 Gene

HapMap Linkage Disequilibrium report
OSBPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL2 Gene

Disorders for OSBPL2 Gene

(1) University of Copenhagen DISEASES for OSBPL2 Gene

Relevant External Links for OSBPL2

Genetic Association Database (GAD)
OSBPL2
Human Genome Epidemiology (HuGE) Navigator
OSBPL2
genes like me logo Genes that share disorders with OSBPL2: view

No data available for UniProtKB/Swiss-Prot for OSBPL2 Gene

Publications for OSBPL2 Gene

  1. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) PerttilAo J. … Olkkonen V.M. (J. Mol. Med. 2009) 3 23 48
  2. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. (PMID: 11279184) Xu Y. … McMaster C.R. (J. Biol. Chem. 2001) 3 4 23
  3. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. (PMID: 19224871) Hynynen R. … Olkkonen V.M. (J. Lipid Res. 2009) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OSBPL2 Gene

Sources for OSBPL2 Gene

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