OSBPL1A Gene
protein-coding GIFtS: 60
GCID: GC18M021742
|
|
oxysterol binding protein-like 1A(Previous name: oxysterol binding protein-like 1B )
(Previous symbol: OSBPL1B)
| |
Aliases
for OSBPL1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oxysterol Binding Protein-Like 1A1 2 | | Oxysterol-Binding Protein-Related Protein 12 | | ORP11 2 3 5 | | Oxysterol-Binding Protein-Related Protein 1 Variant 12 | | ORP-11 2 3 | | Oxysterol-Binding Protein-Related Protein 1 Variant 22 | | OSBPL1B1 2 3 | | OSBP83 | | Oxysterol Binding Protein-Like 1B1 2 | | OSBPL13 | | OSBP-Related Protein 12 3 | | |
Export aliases for OSBPL1A gene to outside databasesPrevious GC identifers: GC18M021634 GC18M021473 GC18M019994 GC18M019993 GC18M019996 GC18M018598 |
Summaries
for OSBPL1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OSBPL1A:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors.Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-likesterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived fromalternative promoter usage and/or alternative splicing exist; they encode different isoforms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OSBL1_HUMAN, Q9BXW6Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional propertiesof late endocytic compartments via its interaction with RAB7A
Gene Wiki entry for OSBPL1A
|
Genomic Views
for OSBPL1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OSBPL1A gene promoter:
NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OSBPL1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q11.1 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2OSBPL1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M021742: view genomic region
(about GC identifiers)
Start:
|
21,742,008 bp from pter |
End:
|
21,977,844 bp from pter |
Size:
|
235,837 bases |
Orientation:
|
minus strand |
|
Proteins
for OSBPL1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OSBL1_HUMAN, Q9BXW6 (See
protein sequence)Recommended Name: Oxysterol-binding protein-related protein 1 Size: 950 amino acids; 108470 Da
Subunit: Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A. Interacts with OAS1B (Bysimilarity)
Subcellular location: Late endosome. Note=Co-localizes with RAB7A, RAB9A and LAMP1 in late endosomes
Sequence caution: Sequence=AAG53407.2; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: B7Z7D3 Q9BZF5 Q9NW87Alternative splicing: 3 isoforms: Q9BXW6-1 Q9BXW6-2 Q9BXW6-4 Explore the universe of human proteins at neXtProt for OSBPL1A: NX_Q9BXW6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXW6
OSBPL1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001229437.1 NP_060500.3 NP_542164.2
ENSEMBL proteins: ENSP00000320291 ENSP00000382372 ENSP00000349545 ENSP00000464617 ENSP00000462155 ENSP00000464541 ENSP00000463452 ENSP00000462887 ENSP00000462477 ENSP00000382370 Reactome Protein details: Q9BXW6
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
OSBPL1A for ontologies About GeneDecksing
OSBPL1A Antibody Products:
Assay Products for OSBPL1A: |
Protein
Domains /
Families
for OSBPL1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OSBPL1A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BXW6ProtoNet protein and cluster: Q9BXW6 3 Blocks protein families: IPB000648 Oxysterol-binding protein IPB001849 Pleckstrin-like IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: OSBL1_HUMAN, Q9BXW6Similarity: Belongs to the OSBP familySimilarity: Contains 3 ANK repeatsSimilarity: Contains 1 PH domain |
Function
for OSBPL1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OSBL1_HUMAN, Q9BXW6Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional propertiesof late endocytic compartments via its interaction with RAB7A
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): OSBPL1A (NM_080597) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSBPL1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL1A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
OSBPL1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for OSBPL1A:
Animal Models:
1 MGI phenotypic allele  for Osbpl1a (no phenotypes)
OSBPL1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for OSBPL1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | MHC class II antigen presentation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OSBPL1A
OSBPL1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSBPL1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/22 Interacting proteins for OSBPL1A (Q9BXW63 ENSP000003202914) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
OSBPL1A for ontologies About GeneDecksing
|
Drugs & Compounds
for OSBPL1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OSBPL1A
10/12 HMDB Compounds for OSBPL1A (see all 12) About this table
Search CenterWatch for drugs/clinical trials and news about OSBPL1A / OSBL1
|
Transcripts
for OSBPL1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OSBPL1A gene (4 alternative transcripts): NM_001242508.1 NM_018030.4 NM_080597.3 NM_133268.1 Unigene Cluster for OSBPL1A: Oxysterol binding protein-like 1A Hs.370725 [show with all ESTs]Unigene Representative Sequence: NM_08059716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319481(uc010xbc.2 uc002kve.3 uc002kvf.3) ENST00000399443(uc002kvd.3)
ENST00000357041 ENST00000578013 ENST00000578055 ENST00000585247 ENST00000584119
ENST00000581043 ENST00000579851 ENST00000578091 ENST00000582645 ENST00000579764
ENST00000582350 ENST00000399441 ENST00000582618 ENST00000581343
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): OSBPL1A (NM_080597) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSBPL1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL1A |
Additional cDNA sequence: AF274714.1 AF392449.1 AF392450.1 AK096358.1 AK292895.1 AK301862.1 AK314552.1 BC007004.1 BC022293.1 BC041563.1 BC063420.1 BC073854.1 BC098384.1 BC136452.1 BC144117.1 17 DOTS entries: DT.87016353 DT.100785333 DT.121098044 DT.100785332 DT.100785334 DT.106801 DT.100026893 DT.121098039 DT.65287463 DT.121098001 DT.121098068 DT.40235162 DT.75145841 DT.75170568 DT.92008038 DT.95361850 DT.95328698 24/214 AceView cDNA sequences (see all 214): AI018595 NM_080597 BM703506 BF221671 BM783873 BX951868 CA425827 BU729423 AI336750 BU149361 AI537740 BC073854 BM562751 BQ009149 AF274714 AI420848 BM460621 AU119897 BE293936 BM837990 AI078098 AL134482 BM979955 AI431667
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL1A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OSBPL1A
|
Expression
for OSBPL1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OSBPL1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGTATCAA
About this image
See OSBPL1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSBPL1A
SOURCE GeneReport for Unigene cluster: Hs.370725
SABiosciences Expression via Pathway-Focused PCR Array including OSBPL1A: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBPL1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL1A |
Orthologs
for OSBPL1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OSBPL1A gene from 5/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
OSBPL1A1 |
oxysterol binding protein-like 1A |
78.21(n)
82.11(a) |
|
421079 XM_419165.3 XP_419165.2 |
lizard
(Anolis carolinensis) |
Reptilia |
OSBPL1A6 |
-- |
78(a) |
1 ↔ 1 |
4(37791422-37875583) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.180032 |
Transcribed sequence with moderate similarity to protein more |
80.42(n) |
|
BX753742.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
osbpl1a1 |
oxysterol binding protein-like 1A |
67.3(n)
70.02(a) |
|
565503 NM_001045082.2 NP_001038547.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG38601 , 3 |
oxysterol binding3
CG38601 |
51(a)3
55.69(n)1
55.69(a)1 |
|
378251 NM_138021.21 NP_611865.11 |
ENSEMBL Gene Tree for OSBPL1A (if available)
TreeFam Gene Tree for OSBPL1A (if available) |
Paralogs
for OSBPL1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OSBPL1A gene
- OSBP2 OSBPL32 OSBPL72 OSBP22 OSBPL22 OSBPL62
18/19 SIMAP similar genes for OSBPL1A using alignment to 12 protein entries: OSBL1_HUMAN (see all proteins)
(see all similar genes):OSBPL2 CASKIN2 ANKRD11 ANKRD44 ANKRD54 NRARP
SHANK3 OSBP2 ANKRD42 INVS ANKRD6 OSBPL7
ANKRD12 ANKS3 ANKFY1 DKFZp761E1322 MTPN OSBP
OSBPL1A for paralogs About GeneDecksing
|
Genomic Variants
for OSBPL1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OSBPL1A (21742008 - 21977844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for OSBPL1A
4 CNVs: 88754 77830 102611 102612 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL1A |
|
Disorders
/ Diseases
for OSBPL1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSBPL1A for disorders About GeneDecksing
OMIM gene information: 606730
OMIM disorders: --
3  diseases for OSBPL1A: About MalaCardsosteoporosis cholesterol malaria
Human Genome Epidemiology (HuGE) Navigator: OSBPL1A (2 documents)
Export disorders for OSBPL1A gene to outside databases
|
Publications
for OSBPL1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OSBPL1A gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with OSBPL1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. (PubMed id 11279184)1, 2, 3, 9 Xu Y.... McMaster C.R. (2001)
- Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PubMed id 10588946)1, 3, 9 Laitinen S....Ikonen E. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. (PubMed id 16176980)1, 2 Johansson M....Olkkonen V.M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (2001)
- The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (2001)
- The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct. (PubMed id 12631712)1, 9 Johansson M....Olkkonen V.M. (2003)
- Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE. (PubMed id 22728266)1 Lee S....Michaely P. (2012)
- Sterol binding by OSBP-related protein 1L regulates l ate endosome motility and function. (PubMed id 20690035)1 Vihervaara T....Olkkonen V.M. (2011)
|
External Searches for OSBPL1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OSBPL1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OSBPL1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSBPL1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OSBPL1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OSBPL1A gene:
Search GeneIP for patents involving OSBPL1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for OSBPL1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for OSBPL1A | | OriGene shRNA RFP for OSBPL1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBPL1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL1A | | | OriGene Protein Over-expression Lysate for OSBPL1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OSBPL1A | | OriGene 3'-UTR Clone for OSBPL1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OSBPL1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OSBPL1A | | OriGene Custom Protein Services for OSBPL1A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSBPL1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBPL1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL1A |
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| | | | Search Tocris compounds for OSBPL1A |
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 | | | OSBPL1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL1A |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL1A |
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