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Aliases for OSBPL11 Gene

Aliases for OSBPL11 Gene

  • Oxysterol Binding Protein-Like 11 2 3
  • OSBP-Related Protein 11 3 4
  • ORP-11 3 4
  • OSBP12 3 4
  • ORP11 3 4
  • TCCCIA00292 3

External Ids for OSBPL11 Gene

Previous GeneCards Identifiers for OSBPL11 Gene

  • GC03M122014
  • GC03M125278
  • GC03M126529
  • GC03M126568
  • GC03M126730
  • GC03M122623

Summaries for OSBPL11 Gene

Entrez Gene Summary for OSBPL11 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL11 Gene

OSBPL11 (Oxysterol Binding Protein-Like 11) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL10.

UniProtKB/Swiss-Prot for OSBPL11 Gene

  • Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Gene Wiki entry for OSBPL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL11 Gene

Genomics for OSBPL11 Gene

Regulatory Elements for OSBPL11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSBPL11 Gene

Chromosome:
3
Start:
125,528,858 bp from pter
End:
125,595,537 bp from pter
Size:
66,680 bases
Orientation:
Minus strand

Genomic View for OSBPL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL11 Gene

Proteins for OSBPL11 Gene

  • Protein details for OSBPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXB4-OSB11_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 11
    Protein Accession:
    Q9BXB4
    Secondary Accessions:
    • A8K9I7

    Protein attributes for OSBPL11 Gene

    Size:
    747 amino acids
    Molecular mass:
    83643 Da
    Quaternary structure:
    • Heterodimer with OSBPL9.

    Three dimensional structures from OCA and Proteopedia for OSBPL11 Gene

neXtProt entry for OSBPL11 Gene

Proteomics data for OSBPL11 Gene at MOPED

Post-translational modifications for OSBPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OSBPL11 Gene

Domains & Families for OSBPL11 Gene

Protein Domains for OSBPL11 Gene

Suggested Antigen Peptide Sequences for OSBPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXB4

UniProtKB/Swiss-Prot:

OSB11_HUMAN :
  • The PH domain binds phosphoinositides.
  • Belongs to the OSBP family.
Domain:
  • The PH domain binds phosphoinositides.
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL11: view

Function for OSBPL11 Gene

Molecular function for OSBPL11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Gene Ontology (GO) - Molecular Function for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with OSBPL11: view

Phenotypes for OSBPL11 Gene

GenomeRNAi human phenotypes for OSBPL11:
genes like me logo Genes that share phenotypes with OSBPL11: view

Animal Model Products

CRISPR Products

miRNA for OSBPL11 Gene

miRTarBase miRNAs that target OSBPL11

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL11 Gene

Localization for OSBPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL11 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL11 Gene COMPARTMENTS Subcellular localization image for OSBPL11 gene
Compartment Confidence
endosome 3
golgi apparatus 3
nucleus 2

Gene Ontology (GO) - Cellular Components for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with OSBPL11: view

Pathways & Interactions for OSBPL11 Gene

SuperPathways for OSBPL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0010890 positive regulation of sequestering of triglyceride IMP 23028956
GO:0045444 fat cell differentiation IMP 23028956
genes like me logo Genes that share ontologies with OSBPL11: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL11 Gene

Drugs & Compounds for OSBPL11 Gene

No Compound Related Data Available

Transcripts for OSBPL11 Gene

mRNA/cDNA for OSBPL11 Gene

Unigene Clusters for OSBPL11 Gene

Oxysterol binding protein-like 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL11 Gene

No ASD Table

Relevant External Links for OSBPL11 Gene

GeneLoc Exon Structure for
OSBPL11
ECgene alternative splicing isoforms for
OSBPL11

Expression for OSBPL11 Gene

mRNA expression in normal human tissues for OSBPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL11 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

Protein differential expression in normal tissues from HIPED for OSBPL11 Gene

This gene is overexpressed in Monocytes (25.8), Peripheral blood mononuclear cells (9.6), and Ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL11 Gene



SOURCE GeneReport for Unigene cluster for OSBPL11 Gene Hs.477440

mRNA Expression by UniProt/SwissProt for OSBPL11 Gene

Q9BXB4-OSB11_HUMAN
Tissue specificity: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).
genes like me logo Genes that share expression patterns with OSBPL11: view

Protein tissue co-expression partners for OSBPL11 Gene

Primer Products

In Situ Assay Products

Orthologs for OSBPL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSBPL11 35
  • 92.28 (n)
  • 93.98 (a)
OSBPL11 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL11 35
  • 92.46 (n)
  • 93.84 (a)
OSBPL11 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl11 35
  • 86.73 (n)
  • 91.55 (a)
Osbpl11 16
Osbpl11 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSBPL11 35
  • 99.51 (n)
  • 99.46 (a)
OSBPL11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl11 35
  • 87.48 (n)
  • 91.92 (a)
oppossum
(Monodelphis domestica)
Mammalia OSBPL11 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL11 35
  • 77.23 (n)
  • 84.23 (a)
OSBPL11 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL11 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl11 35
  • 67.04 (n)
  • 73.79 (a)
Str.8471 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13782 35
zebrafish
(Danio rerio)
Actinopterygii osbpl11 35
  • 67.41 (n)
  • 73.43 (a)
osbpl11 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9205 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH6 36
  • 27 (a)
ManyToMany
OSH7 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1971 36
  • 43 (a)
OneToMany
Species with no ortholog for OSBPL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL11 Gene

ENSEMBL:
Gene Tree for OSBPL11 (if available)
TreeFam:
Gene Tree for OSBPL11 (if available)

Paralogs for OSBPL11 Gene

Paralogs for OSBPL11 Gene

(2) SIMAP similar genes for OSBPL11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSBPL11: view

Variants for OSBPL11 Gene

Sequence variations from dbSNP and Humsavar for OSBPL11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10547 -- 125,595,172(+) ACGGA(C/T)AGGGG utr-variant-5-prime
rs754545 -- 125,587,430(+) tcagc(A/G)tataa intron-variant
rs768155 -- 125,537,701(-) TGTCC(C/T)TCTAT intron-variant
rs935540 -- 125,582,465(+) ATAAA(A/G)TATTT intron-variant
rs935541 -- 125,567,855(-) CACCA(G/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL11 Gene

Variant ID Type Subtype PubMed ID
nsv10311 CNV Gain 18304495
nsv829713 CNV Gain 17160897
nsv829714 CNV Gain 17160897
nsv507123 CNV Insertion 20534489

Variation tolerance for OSBPL11 Gene

Residual Variation Intolerance Score: 10.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL11 Gene

HapMap Linkage Disequilibrium report
OSBPL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL11 Gene

Disorders for OSBPL11 Gene

Relevant External Links for OSBPL11

Genetic Association Database (GAD)
OSBPL11
Human Genome Epidemiology (HuGE) Navigator
OSBPL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSBPL11
genes like me logo Genes that share disorders with OSBPL11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL11 Gene

Publications for OSBPL11 Gene

  1. Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. (PMID: 19325544) Bouchard L. … Vohl M.C. (Obesity (Silver Spring) 2009) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. (PMID: 24885147) Baron Y. … Alexandru G. (BMC Biol. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for OSBPL11 Gene

Sources for OSBPL11 Gene

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