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Aliases for OSBPL11 Gene

Aliases for OSBPL11 Gene

  • Oxysterol Binding Protein Like 11 2 3 5
  • OSBP-Related Protein 11 3 4
  • ORP-11 3 4
  • OSBP12 3 4
  • ORP11 3 4
  • Oxysterol-Binding Protein-Related Protein 11 3
  • Oxysterol Binding Protein-Like 11 2
  • Testicular Tissue Protein Li 132 3
  • TCCCIA00292 3

External Ids for OSBPL11 Gene

Previous GeneCards Identifiers for OSBPL11 Gene

  • GC03M122014
  • GC03M125278
  • GC03M126529
  • GC03M126568
  • GC03M126730
  • GC03M122623

Summaries for OSBPL11 Gene

Entrez Gene Summary for OSBPL11 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL11 Gene

OSBPL11 (Oxysterol Binding Protein Like 11) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL10.

UniProtKB/Swiss-Prot for OSBPL11 Gene

  • Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Gene Wiki entry for OSBPL11 Gene

Additional gene information for OSBPL11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL11 Gene

Genomics for OSBPL11 Gene

Regulatory Elements for OSBPL11 Gene

Enhancers for OSBPL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H125632 1.5 FANTOM5 Ensembl ENCODE 5.2 -37.7 -37664 2 HDAC1 PKNOX1 ATF1 ZNF766 ATF7 CAVIN1 ZNF592 TFDP1 HMBOX1 NR2C1 ENSG00000242001 FAM86JP OR7E93P OSBPL11 LOC101927056 PIR57986 ENSG00000243072
GH03H125194 0.8 Ensembl ENCODE 6.6 +400.4 400419 1.1 IKZF1 JUNB RUNX3 BATF RAD21 OSBPL11 GC03M125183 SLC12A8
GH03H125519 1 ENCODE 4.5 +75.4 75365 2.3 HDGF MLX ARNT ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 ATF7 OR7E29P SLC12A8 OSBPL11 ENSG00000201800 SNX4
GH03H125145 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +447.5 447527 4.4 SCRT1 CTCF HLF CEBPB CEBPG RELA POLR2A EED SCRT2 HNF4A SLC12A8 OSBPL11 MIR5092 RNU6-230P
GH03H125211 0.5 ENCODE 7.3 +382.4 382382 3 JUND POLR2A DPF2 ZFX TEAD3 SLC12A8 RNU6-232P OSBPL11 GC03M125226
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSBPL11 on UCSC Golden Path with GeneCards custom track

Promoters for OSBPL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for OSBPL11 Gene

Genomic Locations for OSBPL11 Gene
66,680 bases
Minus strand

Genomic View for OSBPL11 Gene

Genes around OSBPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL11 Gene

Proteins for OSBPL11 Gene

  • Protein details for OSBPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 11
    Protein Accession:
    Secondary Accessions:
    • A8K9I7

    Protein attributes for OSBPL11 Gene

    747 amino acids
    Molecular mass:
    83643 Da
    Quaternary structure:
    • Heterodimer with OSBPL9.

    Three dimensional structures from OCA and Proteopedia for OSBPL11 Gene

neXtProt entry for OSBPL11 Gene

Post-translational modifications for OSBPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSBPL11 Gene

Domains & Families for OSBPL11 Gene

Gene Families for OSBPL11 Gene

Protein Domains for OSBPL11 Gene

Suggested Antigen Peptide Sequences for OSBPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PH domain binds phosphoinositides.
  • Belongs to the OSBP family.
  • The PH domain binds phosphoinositides.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL11: view

Function for OSBPL11 Gene

Molecular function for OSBPL11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Gene Ontology (GO) - Molecular Function for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with OSBPL11: view

Phenotypes for OSBPL11 Gene

genes like me logo Genes that share phenotypes with OSBPL11: view

Animal Model Products

CRISPR Products

miRNA for OSBPL11 Gene

miRTarBase miRNAs that target OSBPL11

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL11 Gene

Localization for OSBPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL11 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSBPL11 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
endosome 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0016020 membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with OSBPL11: view

Pathways & Interactions for OSBPL11 Gene

SuperPathways for OSBPL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0010890 positive regulation of sequestering of triglyceride IMP 23028956
GO:0045444 fat cell differentiation IMP 23028956
genes like me logo Genes that share ontologies with OSBPL11: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL11 Gene

Drugs & Compounds for OSBPL11 Gene

No Compound Related Data Available

Transcripts for OSBPL11 Gene

mRNA/cDNA for OSBPL11 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(163) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OSBPL11 Gene

Oxysterol binding protein-like 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL11 Gene

No ASD Table

Relevant External Links for OSBPL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSBPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL11 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

Protein differential expression in normal tissues from HIPED for OSBPL11 Gene

This gene is overexpressed in Monocytes (25.8), Peripheral blood mononuclear cells (9.6), and Ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSBPL11 Gene

Protein tissue co-expression partners for OSBPL11 Gene

NURSA nuclear receptor signaling pathways regulating expression of OSBPL11 Gene:


SOURCE GeneReport for Unigene cluster for OSBPL11 Gene:


mRNA Expression by UniProt/SwissProt for OSBPL11 Gene:

Tissue specificity: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).

Evidence on tissue expression from TISSUES for OSBPL11 Gene

  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with OSBPL11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OSBPL11 Gene

Orthologs for OSBPL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSBPL11 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia OSBPL11 33 34
  • 92.46 (n)
(Bos Taurus)
Mammalia OSBPL11 33 34
  • 92.28 (n)
(Rattus norvegicus)
Mammalia Osbpl11 33
  • 87.48 (n)
(Mus musculus)
Mammalia Osbpl11 33 16 34
  • 86.73 (n)
(Monodelphis domestica)
Mammalia OSBPL11 34
  • 86 (a)
(Gallus gallus)
Aves OSBPL11 33 34
  • 77.23 (n)
(Anolis carolinensis)
Reptilia OSBPL11 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl11 33
  • 67.04 (n)
Str.8471 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13782 33
(Danio rerio)
Actinopterygii osbpl11 33 34
  • 67.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9205 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH7 34
  • 30 (a)
OSH6 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1971 34
  • 43 (a)
Species where no ortholog for OSBPL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL11 Gene

Gene Tree for OSBPL11 (if available)
Gene Tree for OSBPL11 (if available)

Paralogs for OSBPL11 Gene

Paralogs for OSBPL11 Gene

(2) SIMAP similar genes for OSBPL11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSBPL11: view

Variants for OSBPL11 Gene

Sequence variations from dbSNP and Humsavar for OSBPL11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs746035150 A breast cancer sample 125,576,304(+) TCTGC(A/G)ATATA nc-transcript-variant, reference, missense
rs1000132680 -- 125,584,971(+) GGGGG(C/G/T)GTCTC intron-variant
rs1000157621 -- 125,544,740(+) AGATG(C/G)CCCTA intron-variant
rs1000169369 -- 125,541,182(+) GAACT(C/G)ATCAC intron-variant
rs1000182866 -- 125,566,476(+) GCACA(C/T)ATGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL11 Gene

Variant ID Type Subtype PubMed ID
nsv829714 CNV gain 17160897
nsv829713 CNV gain 17160897
nsv591465 CNV gain 21841781
nsv507123 OTHER sequence alteration 20534489
nsv10311 CNV gain 18304495
nsv1011457 CNV gain 25217958

Variation tolerance for OSBPL11 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL11 Gene

Disorders for OSBPL11 Gene

Relevant External Links for OSBPL11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSBPL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL11 Gene

Publications for OSBPL11 Gene

  1. Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. (PMID: 19325544) Bouchard L … Vohl MC (Obesity (Silver Spring, Md.) 2009) 3 22 45 60
  2. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. (PMID: 23028956) Zhou Y … Olkkonen VM (PloS one 2012) 3 4 60
  3. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PMID: 20599956) Zhou Y … Olkkonen VM (Experimental cell research 2010) 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60

Products for OSBPL11 Gene

Sources for OSBPL11 Gene

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