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Aliases for OSBPL11 Gene

Aliases for OSBPL11 Gene

  • Oxysterol Binding Protein Like 11 2 3 5
  • Oxysterol Binding Protein-Like 11 2 3
  • OSBP-Related Protein 11 3 4
  • ORP-11 3 4
  • OSBP12 3 4
  • ORP11 3 4
  • Testicular Tissue Protein Li 132 3
  • TCCCIA00292 3

External Ids for OSBPL11 Gene

Previous GeneCards Identifiers for OSBPL11 Gene

  • GC03M122014
  • GC03M125278
  • GC03M126529
  • GC03M126568
  • GC03M126730
  • GC03M122623

Summaries for OSBPL11 Gene

Entrez Gene Summary for OSBPL11 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL11 Gene

OSBPL11 (Oxysterol Binding Protein Like 11) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL10.

UniProtKB/Swiss-Prot for OSBPL11 Gene

  • Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Gene Wiki entry for OSBPL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL11 Gene

Genomics for OSBPL11 Gene

Regulatory Elements for OSBPL11 Gene

Enhancers for OSBPL11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSBPL11 on UCSC Golden Path with GeneCards custom track

Promoters for OSBPL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OSBPL11 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSBPL11 Gene

125,528,858 bp from pter
125,595,537 bp from pter
66,680 bases
Minus strand

Genomic View for OSBPL11 Gene

Genes around OSBPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL11 Gene

Proteins for OSBPL11 Gene

  • Protein details for OSBPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxysterol-binding protein-related protein 11
    Protein Accession:
    Secondary Accessions:
    • A8K9I7

    Protein attributes for OSBPL11 Gene

    747 amino acids
    Molecular mass:
    83643 Da
    Quaternary structure:
    • Heterodimer with OSBPL9.

    Three dimensional structures from OCA and Proteopedia for OSBPL11 Gene

neXtProt entry for OSBPL11 Gene

Proteomics data for OSBPL11 Gene at MOPED

Post-translational modifications for OSBPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSBPL11 Gene

Domains & Families for OSBPL11 Gene

Protein Domains for OSBPL11 Gene

Suggested Antigen Peptide Sequences for OSBPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PH domain binds phosphoinositides.
  • Belongs to the OSBP family.
  • The PH domain binds phosphoinositides.
  • Contains 1 PH domain.
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL11: view

Function for OSBPL11 Gene

Molecular function for OSBPL11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).

Phenotypes for OSBPL11 Gene

genes like me logo Genes that share phenotypes with OSBPL11: view

Animal Model Products

CRISPR Products

miRNA for OSBPL11 Gene

miRTarBase miRNAs that target OSBPL11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL11 Gene

Localization for OSBPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL11 Gene

Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.

Subcellular locations from

Jensen Localization Image for OSBPL11 Gene COMPARTMENTS Subcellular localization image for OSBPL11 gene
Compartment Confidence
endosome 4
golgi apparatus 4
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for OSBPL11 Gene

Pathways & Interactions for OSBPL11 Gene

SuperPathways for OSBPL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010890 positive regulation of sequestering of triglyceride IMP 23028956
genes like me logo Genes that share ontologies with OSBPL11: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL11 Gene

Drugs & Compounds for OSBPL11 Gene

No Compound Related Data Available

Transcripts for OSBPL11 Gene

mRNA/cDNA for OSBPL11 Gene

Unigene Clusters for OSBPL11 Gene

Oxysterol binding protein-like 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL11 Gene

No ASD Table

Relevant External Links for OSBPL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSBPL11 Gene

mRNA expression in normal human tissues for OSBPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL11 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

Protein differential expression in normal tissues from HIPED for OSBPL11 Gene

This gene is overexpressed in Monocytes (25.8), Peripheral blood mononuclear cells (9.6), and Ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL11 Gene

SOURCE GeneReport for Unigene cluster for OSBPL11 Gene Hs.477440

mRNA Expression by UniProt/SwissProt for OSBPL11 Gene

Tissue specificity: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).
genes like me logo Genes that share expression patterns with OSBPL11: view

Protein tissue co-expression partners for OSBPL11 Gene

Primer Products

Orthologs for OSBPL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSBPL11 35
  • 92.28 (n)
  • 93.98 (a)
OSBPL11 36
  • 94 (a)
(Canis familiaris)
Mammalia OSBPL11 35
  • 92.46 (n)
  • 93.84 (a)
OSBPL11 36
  • 94 (a)
(Mus musculus)
Mammalia Osbpl11 35
  • 86.73 (n)
  • 91.55 (a)
Osbpl11 16
Osbpl11 36
  • 91 (a)
(Pan troglodytes)
Mammalia OSBPL11 35
  • 99.51 (n)
  • 99.46 (a)
OSBPL11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Osbpl11 35
  • 87.48 (n)
  • 91.92 (a)
(Monodelphis domestica)
Mammalia OSBPL11 36
  • 86 (a)
(Gallus gallus)
Aves OSBPL11 35
  • 77.23 (n)
  • 84.23 (a)
OSBPL11 36
  • 83 (a)
(Anolis carolinensis)
Reptilia OSBPL11 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl11 35
  • 67.04 (n)
  • 73.79 (a)
Str.8471 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13782 35
(Danio rerio)
Actinopterygii osbpl11 35
  • 67.41 (n)
  • 73.43 (a)
osbpl11 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9205 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH6 36
  • 27 (a)
OSH7 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1971 36
  • 43 (a)
Species with no ortholog for OSBPL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL11 Gene

Gene Tree for OSBPL11 (if available)
Gene Tree for OSBPL11 (if available)

Paralogs for OSBPL11 Gene

Paralogs for OSBPL11 Gene

(2) SIMAP similar genes for OSBPL11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OSBPL11: view

Variants for OSBPL11 Gene

Sequence variations from dbSNP and Humsavar for OSBPL11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036100 A breast cancer sample
rs10547 -- 125,595,172(+) ACGGA(C/T)AGGGG utr-variant-5-prime
rs754545 -- 125,587,430(+) tcagc(A/G)tataa intron-variant
rs768155 -- 125,537,701(-) TGTCC(C/T)TCTAT intron-variant
rs1055419 -- 125,594,988(+) CTTTT(A/G)AGAGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OSBPL11 Gene

Variant ID Type Subtype PubMed ID
nsv10311 CNV Gain 18304495
nsv829713 CNV Gain 17160897
nsv829714 CNV Gain 17160897
nsv507123 CNV Insertion 20534489

Variation tolerance for OSBPL11 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSBPL11 Gene

Disorders for OSBPL11 Gene

Relevant External Links for OSBPL11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSBPL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL11 Gene

Publications for OSBPL11 Gene

  1. Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. (PMID: 19325544) Bouchard L. … Vohl M.C. (Obesity (Silver Spring) 2009) 3 23 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for OSBPL11 Gene

Sources for OSBPL11 Gene