OSBPL11 Gene
protein-coding GIFtS: 48
GCID: GC03M125278
|
|
oxysterol binding protein-like 11
| |
Aliases
for OSBPL11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oxysterol Binding Protein-Like 111 2 | | FLJ130121 | | ORP111 2 3 5 | | FLJ131641 | | ORP-111 2 3 | | TCCCIA002922 | | OSBP122 3 | | Oxysterol-Binding Protein-Related Protein 112 | | OSBP-Related Protein 112 3 | | |
Export aliases for OSBPL11 gene to outside databasesPrevious GC identifers: GC03M122014 GC03M126529 GC03M126568 GC03M126730 GC03M122623 |
Summaries
for OSBPL11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OSBPL11:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors.Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conservedC-terminal OSBP-like sterol-binding domain. (provided by RefSeq, Jul 2008)
Gene Wiki entry for OSBPL11
|
Genomic Views
for OSBPL11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OSBPL11 gene promoter:
RFX1 GCNF NCX/Ncx Brachyury Tal-1beta E2F E2F-1 GCNF-1 IRF-7A ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OSBPL11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21 Ensembl cytogenetic band: 3q21.2 HGNC cytogenetic band: 3q21OSBPL11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M125278: view genomic region
(about GC identifiers)
Start:
|
125,247,702 bp from pter |
End:
|
125,314,381 bp from pter |
Size:
|
66,680 bases |
Orientation:
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minus strand |
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Proteins
for OSBPL11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OSB11_HUMAN, Q9BXB4 (See
protein sequence)Recommended Name: Oxysterol-binding protein-related protein 11 Size: 747 amino acids; 83643 Da
1 PDB 3D structure from  and Proteopedia  for OSBPL11:2D9X (3D)
Secondary accessions: A8K9I7Explore the universe of human proteins at neXtProt for OSBPL11: NX_Q9BXB4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXB4
OSBPL11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073613.2
ENSEMBL proteins: ENSP00000296220
Human Recombinant Protein Products:
OSBPL11 Antibody Products:
Assay Products for OSBPL11: |
Protein
Domains /
Families
for OSBPL11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OSBPL11 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXB4ProtoNet protein and cluster: Q9BXB4 2 Blocks protein families: IPB000648 Oxysterol-binding protein IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: OSB11_HUMAN, Q9BXB4Similarity: Belongs to the OSBP familySimilarity: Contains 1 PH domain |
Function
for OSBPL11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: OSBPL11 (NM_022776) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- |
OSBPL11 for ontologies About GeneDecksing
|
Pathways & Interactions
for OSBPL11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSBPL11
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for OSBPL11 (Q9BXB43 ENSP000002962204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006869 | lipid transport |
IEA | -- | | GO:0010890 | positive regulation of sequestering of triglyceride |
IMP | -- | | GO:0045444 | fat cell differentiation |
IMP | -- |
OSBPL11 for ontologies About GeneDecksing
|
Drugs & Compounds
for OSBPL11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OSBPL11
Search CenterWatch for drugs/clinical trials and news about OSBPL11 / OSB11
|
Transcripts
for OSBPL11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OSBPL11 gene: NM_022776.4 Unigene Cluster for OSBPL11: Oxysterol binding protein-like 11 Hs.477440 [show with all ESTs]Unigene Representative Sequence: NM_0227761 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000296220(uc003eic.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OSBPL11 (NM_022776) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OSBPL11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBPL11 |
Additional cDNA sequence: AF346292.1 AF392454.1 AK023074.1 AK023226.1 AK292702.1 AY007102.1 BC010422.1 BC065213.1 6 DOTS entries: DT.454728 DT.120840226 DT.91909903 DT.75102759 DT.91731793 DT.99988080 24/163 AceView cDNA sequences (see all 163): AI360060 CA425413 AA337356 CA307380 AA251918 N41739 AF346292 CA841922 BF940600 BC010422 AU143256 AU132028 AF318344 AA769310 AA639510 CR613218 AI276257 CA842219 AL538652 AI684798 AA251762 AA026295 AA825817 AI985194
GeneLoc Exon Structure
|
Expression
for OSBPL11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OSBPL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OSBPL11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OSBPL11
SOURCE GeneReport for Unigene cluster: Hs.477440
UniProtKB/Swiss-Prot: OSB11_HUMAN, Q9BXB4Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for OSBPL11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBPL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL11 |
Orthologs
for OSBPL11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for OSBPL11 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
OSBPL111 |
oxysterol binding protein-like 11 |
77.13(n)
84.09(a) |
|
424262 XM_422109.3 XP_422109.3 |
lizard
(Anolis carolinensis) |
Reptilia |
OSBPL116 |
-- |
80(a) |
1 ↔ 1 |
1(77664878-77698645) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.137822 |
Xenopus laevis transcribed sequence with moderate similarity more |
73.01(n) |
|
BJ083704.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
osbpl111 |
oxysterol binding protein-like 11 |
67.5(n)
74.19(a) |
|
560514 XM_683921.4 XP_689013.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ORP4C6ORP4A6(see all 3) |
OSBP(oxysterol binding protein)-related protein 4C...OSBP(oxysterol binding protein)-related protein 4A...(see all 3) |
21(a)20(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
5(23193163-23195476) 4(13147326-13149606) |
rice
(Oryza sativa) |
Liliopsida |
-- |
oxysterol-binding protein, putative, expressed |
19(a) |
1 → many |
8(25692094-25696925) |
ENSEMBL Gene Tree for OSBPL11 (if available)
TreeFam Gene Tree for OSBPL11 (if available) |
Paralogs
for OSBPL11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OSBPL11 gene
- OSBPL102 OSBPL52 OSBPL92 OSBPL82
2 SIMAP similar genes for OSBPL11 using alignment to 1 protein entry: OSB11_HUMAN:OSBPL10 OSBPL9
OSBPL11 for paralogs About GeneDecksing
|
Genomic Variants
for OSBPL11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OSBPL11 (125247702 - 125314381 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OSBPL11
1 CNV: 31116 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL11 |
|
Disorders
/ Diseases
for OSBPL11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSBPL11 for disorders About GeneDecksing
OMIM gene information: 606739
OMIM disorders: --
2  diseases for OSBPL11: About MalaCardsobesity malaria
Human Genome Epidemiology (HuGE) Navigator: OSBPL11 (4 documents)
Export disorders for OSBPL11 gene to outside databases
|
Publications
for OSBPL11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OSBPL11 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with OSBPL11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (2001)
- A family of 12 human genes containing oxysterol-binding domains. (PubMed id 11735225)1, 2 Jaworski C.J.... Rodriguez I.R. (2001)
- Association of OSBPL11 Gene Polymorphisms With Cardiovascular Disease Risk Factors in Obesity. (PubMed id 19325544)1, 9 Bouchard L....Vohl M.C. (2009)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for OSBPL11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OSBPL11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OSBPL11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSBPL11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OSBPL11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OSBPL11 gene:
Search GeneIP for patents involving OSBPL11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OSBPL11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for OSBPL11 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBPL11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OSBPL11 | | | OriGene Protein Over-expression Lysate for OSBPL11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OSBPL11 | | OriGene 3'-UTR Clone for OSBPL11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBPL11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OSBPL11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OSBPL11 | | OriGene Custom Protein Services for OSBPL11 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSBPL11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OSBPL11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBPL11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBPL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBPL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBPL11 |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBPL11 |
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