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Aliases for OSBPL10 Gene

Aliases for OSBPL10 Gene

  • Oxysterol Binding Protein Like 10 2 3 5
  • OSBP-Related Protein 10 3 4
  • ORP-10 3 4
  • ORP10 3 4
  • OSBP9 3 4
  • Oxysterol-Binding Protein-Related Protein 10 3
  • Oxysterol Binding Protein-Like 10 2

External Ids for OSBPL10 Gene

Previous GeneCards Identifiers for OSBPL10 Gene

  • GC03M031290
  • GC03M031071
  • GC03M031548
  • GC03M031674

Summaries for OSBPL10 Gene

Entrez Gene Summary for OSBPL10 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for OSBPL10 Gene

OSBPL10 (Oxysterol Binding Protein Like 10) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBPL11.

UniProtKB/Swiss-Prot for OSBPL10 Gene

  • Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL10 Gene

Genomics for OSBPL10 Gene

Regulatory Elements for OSBPL10 Gene

Enhancers for OSBPL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F032002 1.2 Ensembl ENCODE 20.2 +74.1 74132 1.9 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SP5 MXD4 MIER2 PPARG OSBPL10 ZNF860 GPD1L GC03M031986 RPL21P40
GH03F031944 1.2 Ensembl ENCODE 18.3 +130.6 130595 5.0 ELF3 MLX ARID4B DMAP1 THRB RAD21 RARA SLC30A9 CREM MIXL1 OSBPL10 ZNF860 OSBPL10-AS1 GC03P031801 GC03P031803 GC03P031804 PIR35964
GH03F031936 0.8 Ensembl ENCODE 16.4 +140.7 140661 1.4 MTA2 IKZF1 REST ETV6 FOS TBX21 OSBPL10 ZNF860 GC03P031801 GC03P031803 GC03P031804 PIR35964
GH03F031966 1.2 Ensembl ENCODE 10.7 +108.9 108924 5.1 TBP PKNOX1 MLX FEZF1 FOS CREM MIXL1 HMG20B SP5 CEBPB OSBPL10 ZNF860 GC03P031801 GC03P031803 GC03P031804 PIR35964
GH03F031956 1.4 FANTOM5 Ensembl ENCODE 8.4 +117.3 117286 7.3 ELF3 CREM NR2F2 GLIS1 HMBOX1 ZNF24 PRDM1 DRAP1 CTCF JUN OSBPL10 ZNF860 GC03P031801 GC03P031803 GC03P031804 PIR35964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OSBPL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSBPL10 Gene

Chromosome:
3
Start:
31,657,890 bp from pter
End:
32,077,580 bp from pter
Size:
419,691 bases
Orientation:
Minus strand

Genomic View for OSBPL10 Gene

Genes around OSBPL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL10 Gene

Proteins for OSBPL10 Gene

  • Protein details for OSBPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXB5-OSB10_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 10
    Protein Accession:
    Q9BXB5
    Secondary Accessions:
    • B4E212
    • Q9BTU5

    Protein attributes for OSBPL10 Gene

    Size:
    764 amino acids
    Molecular mass:
    83970 Da
    Quaternary structure:
    • Interacts with OSBPL9 (PubMed:22906437). Interacts with DIAPH1 (PubMed:23325789).

    Alternative splice isoforms for OSBPL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL10 Gene

Post-translational modifications for OSBPL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSBPL10 Gene

Domains & Families for OSBPL10 Gene

Protein Domains for OSBPL10 Gene

Suggested Antigen Peptide Sequences for OSBPL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXB5

UniProtKB/Swiss-Prot:

OSB10_HUMAN :
  • The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.
  • Belongs to the OSBP family.
Domain:
  • The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.
  • The PH domain selectively interacts with phosphatidylinositol-4-phosphate.
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL10: view

Function for OSBPL10 Gene

Molecular function for OSBPL10 Gene

UniProtKB/Swiss-Prot Function:
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).

Gene Ontology (GO) - Molecular Function for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 23934110
GO:0008289 lipid binding IEA --
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL10: view
genes like me logo Genes that share phenotypes with OSBPL10: view

Animal Model Products

miRNA for OSBPL10 Gene

miRTarBase miRNAs that target OSBPL10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL10 Gene

Localization for OSBPL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL10 Gene

Cytoplasm, cytoskeleton. Note=Associates with microtubules. {ECO:0000269 PubMed:19554302, ECO:0000269 PubMed:22906437}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSBPL10 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
plasma membrane 2
nucleus 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with OSBPL10: view

Pathways & Interactions for OSBPL10 Gene

genes like me logo Genes that share pathways with OSBPL10: view

Gene Ontology (GO) - Biological Process for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL10: view

No data available for SIGNOR curated interactions for OSBPL10 Gene

Transcripts for OSBPL10 Gene

Unigene Clusters for OSBPL10 Gene

Oxysterol binding protein-like 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: -
SP11:
SP12: - - -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for OSBPL10 Gene

GeneLoc Exon Structure for
OSBPL10
ECgene alternative splicing isoforms for
OSBPL10

Expression for OSBPL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSBPL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL10 Gene

This gene is overexpressed in Bladder (x4.3).

Protein differential expression in normal tissues from HIPED for OSBPL10 Gene

This gene is overexpressed in Breast (53.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSBPL10 Gene



NURSA nuclear receptor signaling pathways regulating expression of OSBPL10 Gene:

OSBPL10

SOURCE GeneReport for Unigene cluster for OSBPL10 Gene:

Hs.150122
genes like me logo Genes that share expression patterns with OSBPL10: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OSBPL10 Gene

Orthologs for OSBPL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL10 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia OSBPL10 34 35
  • 91.89 (n)
cow
(Bos Taurus)
Mammalia OSBPL10 34 35
  • 88.29 (n)
mouse
(Mus musculus)
Mammalia Osbpl10 34 16 35
  • 86.97 (n)
rat
(Rattus norvegicus)
Mammalia Osbpl10 34
  • 86.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL10 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves OSBPL10 34 35
  • 74.56 (n)
lizard
(Anolis carolinensis)
Reptilia OSBPL10 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl10 34
  • 69.13 (n)
zebrafish
(Danio rerio)
Actinopterygii osbpl10 34 35
  • 64.22 (n)
CABZ01111953.1 35
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8695 34
fruit fly
(Drosophila melanogaster)
Insecta CG9205 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH7 35
  • 30 (a)
ManyToMany
OSH6 35
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1971 35
  • 42 (a)
OneToMany
Species where no ortholog for OSBPL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL10 Gene

ENSEMBL:
Gene Tree for OSBPL10 (if available)
TreeFam:
Gene Tree for OSBPL10 (if available)

Paralogs for OSBPL10 Gene

Paralogs for OSBPL10 Gene

(3) SIMAP similar genes for OSBPL10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OSBPL10: view

Variants for OSBPL10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL10 Gene

OSB10_HUMAN-Q9BXB5
Polymorphisms are associated with dyslipidemia. Variant Asn-254 is associated with LDL-cholesterol levels in Japanese population (PubMed:20224571). Association with peripheral arterial disease has also been oberved (PubMed:20610895).

Sequence variations from dbSNP and Humsavar for OSBPL10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10212189 -- 31,961,622(+) tagag(A/G)caggg intron-variant, upstream-variant-2KB
rs10222499 -- 31,846,356(+) aggtg(A/G)ctcat intron-variant
rs10222500 -- 31,846,399(+) TGAGT(A/G)TATCA intron-variant
rs10222676 -- 31,846,144(+) CGTGG(C/T)GGGGA intron-variant
rs10451988 -- 31,775,062(+) ctcag(A/T)ggggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL10 Gene

Variant ID Type Subtype PubMed ID
esv3364520 CNV insertion 20981092
esv3356190 CNV insertion 20981092
esv3310309 CNV mobile element insertion 20981092
esv3310124 CNV mobile element insertion 20981092
esv3305493 CNV mobile element insertion 20981092
esv3303420 CNV mobile element insertion 20981092
esv2763250 CNV loss 21179565
esv275041 CNV loss 21479260
esv2725101 CNV deletion 23290073
esv2725100 CNV deletion 23290073
esv2725099 CNV deletion 23290073
esv2725098 CNV deletion 23290073
esv2725097 CNV deletion 23290073
esv2725095 CNV deletion 23290073
esv1288233 CNV deletion 17803354
esv1213497 CNV deletion 17803354
esv1027425 CNV insertion 17803354
esv1005278 CNV deletion 20482838
dgv1366e212 CNV loss 25503493
nsv954459 CNV deletion 24416366
nsv818135 CNV loss 17921354
nsv590033 CNV loss 21841781
nsv521977 CNV gain 19592680
nsv516113 CNV loss 19592680
nsv477668 CNV novel sequence insertion 20440878
nsv460485 CNV loss 19166990
nsv1139101 CNV deletion 24896259
nsv1131690 CNV deletion 24896259
nsv1110765 CNV insertion 24896259
nsv1011573 CNV gain 25217958
nsv1003285 CNV gain 25217958
esv988249 CNV deletion 20482838
esv3595763 CNV loss 21293372
esv3595760 CNV loss 21293372
esv3595758 CNV loss 21293372
esv3561690 CNV deletion 23714750
esv3561689 CNV deletion 23714750

Variation tolerance for OSBPL10 Gene

Residual Variation Intolerance Score: 6.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSBPL10

Disorders for OSBPL10 Gene

Relevant External Links for OSBPL10

Genetic Association Database (GAD)
OSBPL10
Human Genome Epidemiology (HuGE) Navigator
OSBPL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSBPL10

No disorders were found for OSBPL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL10 Gene

Publications for OSBPL10 Gene

  1. Variation in OSBPL10 is associated with dyslipidemia. (PMID: 20224571) Koriyama H. … Rakugi H. (Hypertens. Res. 2010) 3 4 22 46 64
  2. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) PerttilAo J. … Olkkonen V.M. (J. Mol. Med. 2009) 3 4 22 46 64
  3. Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. (PMID: 20610895) Koriyama H. … Morishita R. (J. Atheroscler. Thromb. 2010) 3 4 46 64
  4. Interactome map uncovers phosphatidylserine transport by oxysterol- binding proteins. (PMID: 23934110) Maeda K. … Gavin A.C. (Nature 2013) 3 4 64
  5. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. (PMID: 22906437) NissilAo E. … Olkkonen V.M. (Biochim. Biophys. Acta 2012) 3 4 64

Products for OSBPL10 Gene

Sources for OSBPL10 Gene

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