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Aliases for OSBPL10 Gene

Aliases for OSBPL10 Gene

  • Oxysterol Binding Protein-Like 10 2 3
  • OSBP-Related Protein 10 3 4
  • ORP-10 3 4
  • ORP10 3 4
  • OSBP9 3 4

External Ids for OSBPL10 Gene

Previous GeneCards Identifiers for OSBPL10 Gene

  • GC03M031290
  • GC03M031071
  • GC03M031548
  • GC03M031674

Summaries for OSBPL10 Gene

Entrez Gene Summary for OSBPL10 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for OSBPL10 Gene

OSBPL10 (Oxysterol Binding Protein-Like 10) is a Protein Coding gene. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBPL11.

UniProtKB/Swiss-Prot for OSBPL10 Gene

  • Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL10 Gene

Genomics for OSBPL10 Gene

Regulatory Elements for OSBPL10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSBPL10 Gene

Chromosome:
3
Start:
31,657,890 bp from pter
End:
32,077,580 bp from pter
Size:
419,691 bases
Orientation:
Minus strand

Genomic View for OSBPL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for OSBPL10 Gene

Proteins for OSBPL10 Gene

  • Protein details for OSBPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXB5-OSB10_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 10
    Protein Accession:
    Q9BXB5
    Secondary Accessions:
    • B4E212
    • Q9BTU5

    Protein attributes for OSBPL10 Gene

    Size:
    764 amino acids
    Molecular mass:
    83970 Da
    Quaternary structure:
    • Interacts with OSBPL9 (PubMed:22906437). Interacts with DIAPH1 (PubMed:23325789).

    Alternative splice isoforms for OSBPL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL10 Gene

Proteomics data for OSBPL10 Gene at MOPED

Post-translational modifications for OSBPL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBPL10 Gene

Antibody Products

No data available for DME Specific Peptides for OSBPL10 Gene

Domains & Families for OSBPL10 Gene

Protein Domains for OSBPL10 Gene

Suggested Antigen Peptide Sequences for OSBPL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXB5

UniProtKB/Swiss-Prot:

OSB10_HUMAN :
  • The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.
  • Belongs to the OSBP family.
Domain:
  • The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.
  • The PH domain selectively interacts with phosphatidylinositol-4-phosphate.
  • Contains 1 PH domain.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL10: view

Function for OSBPL10 Gene

Molecular function for OSBPL10 Gene

UniProtKB/Swiss-Prot Function:
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).

Gene Ontology (GO) - Molecular Function for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 23934110
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBPL10: view

Phenotypes for OSBPL10 Gene

genes like me logo Genes that share phenotypes with OSBPL10: view

Animal Model Products

CRISPR Products

miRNA for OSBPL10 Gene

miRTarBase miRNAs that target OSBPL10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL10 Gene

Localization for OSBPL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL10 Gene

Cytoplasm, cytoskeleton. Note=Associates with microtubules. {ECO:0000269 PubMed:19554302, ECO:0000269 PubMed:22906437}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBPL10 Gene COMPARTMENTS Subcellular localization image for OSBPL10 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
golgi apparatus 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with OSBPL10: view

Pathways & Interactions for OSBPL10 Gene

SuperPathways for OSBPL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006810 transport --
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBPL10: view

No data available for Pathways by source and SIGNOR curated interactions for OSBPL10 Gene

Drugs & Compounds for OSBPL10 Gene

No Compound Related Data Available

Transcripts for OSBPL10 Gene

Unigene Clusters for OSBPL10 Gene

Oxysterol binding protein-like 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSBPL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: -
SP11:
SP12: - - -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for OSBPL10 Gene

GeneLoc Exon Structure for
OSBPL10
ECgene alternative splicing isoforms for
OSBPL10

Expression for OSBPL10 Gene

mRNA expression in normal human tissues for OSBPL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBPL10 Gene

This gene is overexpressed in Bladder (x4.3).

Protein differential expression in normal tissues from HIPED for OSBPL10 Gene

This gene is overexpressed in Breast (53.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBPL10 Gene



SOURCE GeneReport for Unigene cluster for OSBPL10 Gene Hs.150122

genes like me logo Genes that share expression patterns with OSBPL10: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OSBPL10 Gene

Orthologs for OSBPL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OSBPL10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSBPL10 35
  • 88.29 (n)
  • 92.27 (a)
OSBPL10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL10 35
  • 91.89 (n)
  • 95.65 (a)
OSBPL10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbpl10 35
  • 86.97 (n)
  • 90.52 (a)
Osbpl10 16
Osbpl10 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSBPL10 35
  • 99.61 (n)
  • 99.48 (a)
OSBPL10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl10 35
  • 86.84 (n)
  • 91.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL10 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL10 35
  • 74.56 (n)
  • 77.98 (a)
OSBPL10 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL10 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbpl10 35
  • 69.13 (n)
  • 72.5 (a)
zebrafish
(Danio rerio)
Actinopterygii osbpl10 35
  • 64.22 (n)
  • 66.32 (a)
CABZ01111953.1 36
  • 60 (a)
OneToMany
osbpl10 36
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8695 35
fruit fly
(Drosophila melanogaster)
Insecta CG9205 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH6 36
  • 27 (a)
ManyToMany
OSH7 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1971 36
  • 42 (a)
OneToMany
Species with no ortholog for OSBPL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL10 Gene

ENSEMBL:
Gene Tree for OSBPL10 (if available)
TreeFam:
Gene Tree for OSBPL10 (if available)

Paralogs for OSBPL10 Gene

Paralogs for OSBPL10 Gene

(3) SIMAP similar genes for OSBPL10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OSBPL10: view

Variants for OSBPL10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL10 Gene

Q9BXB5-OSB10_HUMAN
Polymorphisms are associated with dyslipidemia. Variant Asn-254 is associated with LDL-cholesterol levels in Japanese population (PubMed:20224571). Association with peripheral arterial disease has also been oberved (PubMed:20610895).

Sequence variations from dbSNP and Humsavar for OSBPL10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11058 -- 31,661,972(-) CTTGT(A/G)TTAGC utr-variant-3-prime, downstream-variant-500B
rs936160 -- 31,771,093(+) atata(C/T)gtgaa intron-variant
rs936161 -- 31,676,899(-) TTGCT(C/G)TAACA intron-variant
rs1107643 -- 31,675,527(+) AGGCG(A/G)TTCTA intron-variant
rs1107644 -- 31,675,532(+) ATTCT(A/C)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL10 Gene

Variant ID Type Subtype PubMed ID
nsv876670 CNV Gain 21882294
nsv876671 CNV Gain 21882294
nsv876672 CNV Gain 21882294
nsv460485 CNV Loss 19166990
esv275041 CNV Loss 21479260
nsv818135 CNV Loss 17921354
nsv876673 CNV Gain 21882294
esv267699 CNV Insertion 20981092
nsv521977 CNV Gain 19592680
esv2725095 CNV Deletion 23290073
esv2725097 CNV Deletion 23290073
esv988249 CNV Deletion 20482838
esv2725098 CNV Deletion 23290073
esv1288233 CNV Deletion 17803354
esv2725099 CNV Deletion 23290073
esv2725100 CNV Deletion 23290073
esv2725101 CNV Deletion 23290073
esv1005278 CNV Deletion 20482838
esv1213497 CNV Deletion 17803354
nsv876674 CNV Loss 21882294
nsv876675 CNV Gain 21882294
nsv516113 CNV Loss 19592680
esv269770 CNV Insertion 20981092
esv274396 CNV Insertion 20981092
esv1027425 CNV Insertion 17803354
nsv876676 CNV Gain 21882294
esv274581 CNV Insertion 20981092

Variation tolerance for OSBPL10 Gene

Residual Variation Intolerance Score: 6.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OSBPL10 Gene

HapMap Linkage Disequilibrium report
OSBPL10

Disorders for OSBPL10 Gene

Relevant External Links for OSBPL10

Genetic Association Database (GAD)
OSBPL10
Human Genome Epidemiology (HuGE) Navigator
OSBPL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OSBPL10
genes like me logo Genes that share disorders with OSBPL10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL10 Gene

Publications for OSBPL10 Gene

  1. Variation in OSBPL10 is associated with dyslipidemia. (PMID: 20224571) Koriyama H. … Rakugi H. (Hypertens. Res. 2010) 23 67
  2. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. (PMID: 19554302) PerttilAo J. … Olkkonen V.M. (J. Mol. Med. 2009) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. (PMID: 24885147) Baron Y. … Alexandru G. (BMC Biol. 2014) 67
  5. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. (PMID: 24347629) Shaffer J.R. … Marazita M.L. (G3 (Bethesda) 2014) 67

Products for OSBPL10 Gene

Sources for OSBPL10 Gene

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