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OSBP2 Gene

protein-coding   GIFtS: 56
GCID: GC22P031089

Oxysterol Binding Protein 2


(Previous symbol: OSBPL1)
  See OSBP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxysterol Binding Protein 21 2     OSBP-Related Protein 42 3
ORP42 3 5     KIAA16643 5
OSBPL11 2     HLM2
Oxysterol-Binding Protein-Related Protein 42 3     Oxysterol Binding Protein-Like 12
ORP-42 3     Oxysterol-Binding Protein 22
OSBPL42 3     

External Ids:    HGNC: 85041   Entrez Gene: 237622   Ensembl: ENSG000001847927   OMIM: 6067295   UniProtKB: Q969R23   

Export aliases for OSBP2 gene to outside databases

Previous GC identifers: GC22P027786 GC22P029415 GC22P014053


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OSBP2 Gene:
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It
binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for OSBP2 Gene:
OSBP2 (oxysterol binding protein 2) is a protein-coding gene. Diseases associated with OSBP2 include opisthorchiasis. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBPL1A.

UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
Function: Binds 7-ketocholesterol

Gene Wiki entry for OSBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBP2 gene promoter:
         AhR   Pax-5   Pax-6   SREBP-1c   E47   SREBP-1b   Pax-3   SREBP-1a   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOSBP2 promoter sequence
   Search Chromatin IP Primers for OSBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

OSBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBP2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031089:  view genomic region     (about GC identifiers)

Start:
31,089,769 bp from pter      End:
31,303,811 bp from pter
Size:
214,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2 (See protein sequence)
Recommended Name: Oxysterol-binding protein 2  
Size: 916 amino acids; 101266 Da
Sequence caution: Sequence=AAK56864.1; Type=Erroneous initiation; Sequence=AAK56865.1; Type=Erroneous initiation;
Sequence=BAB33334.2; Type=Erroneous initiation;
Secondary accessions: B0QYG1 O60396 Q9BY96 Q9BZF0

Explore the universe of human proteins at neXtProt for OSBP2: NX_Q969R2

Explore proteomics data for OSBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001269667.1  NP_001269668.1  NP_001269669.1  NP_001269670.1  NP_001269671.1  NP_110385.1  

    ENSEMBL proteins: 
     ENSP00000411052   ENSP00000385237   ENSP00000332576   ENSP00000392080   ENSP00000411497  
     ENSP00000385254   ENSP00000388575   ENSP00000409011   ENSP00000401776   ENSP00000415274  
     ENSP00000409838   ENSP00000392362   ENSP00000384213   ENSP00000371747   ENSP00000389200  
     ENSP00000438713  

    OSBP2 Human Recombinant Protein Products:

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    Novus Biologicals OSBP2 Protein
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    antibodies-online proteins for OSBP2 (2 products) 

     
    antibodies-online peptides for OSBP2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q969R2

    ProtoNet protein and cluster: Q969R2

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    Find genes that share domains with OSBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSBP2_HUMAN, Q969R2
    Function: Binds 7-ketocholesterol

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015485cholesterol binding IDA17428193
         
    Find genes that share ontologies with OSBP2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OSBP2

    miRNA
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    miRTarBase miRNAs that target OSBP2:
    hsa-mir-122-5p (MIRT023395), hsa-mir-148b-3p (MIRT019405)

    Block miRNA regulation of human, mouse, rat OSBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBP2 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-519a hsa-miR-890 hsa-miR-124 hsa-miR-372 hsa-miR-637 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OSBP2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSBP2_HUMAN, Q969R2: Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    Find genes that share ontologies with OSBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBP2
    Interactions:

        GeneGlobe Interaction Network for OSBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OSBP2 (Q969R22, 3 ENSP000003325764) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNT1P138052, 3, ENSP000002919014MINT-8275006 I2D: score=2 STRING: ENSP00000291901
    AGPAT1Q999433I2D: score=1 
    ENSG00000206324Q999433I2D: score=1 
    ENSG00000226467Q999433I2D: score=1 
    ENSG00000227642Q999433I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with OSBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OSBP2 gene (7 alternative transcripts): 
    NM_001282738.1  NM_001282739.1  NM_001282740.1  NM_001282741.1  NM_001282742.1  NM_030758.3  NM_001003812.1  

    Unigene Cluster for OSBP2:

    Oxysterol binding protein 2
    Hs.517546  [show with all ESTs]
    Unigene Representative Sequence: NM_030758
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000438716 ENST00000407373(uc010gwc.1) ENST00000332585(uc011ala.1 uc003aix.1 uc003aiy.1 uc003aiz.1 uc003aja.1 uc011ald.1 uc010gwd.1)
    ENST00000446658 ENST00000477355 ENST00000445781 ENST00000401475 ENST00000464341
    ENST00000496367 ENST00000424224 ENST00000454145 ENST00000453621 ENST00000431368
    ENST00000452656 ENST00000496575 ENST00000433183 ENST00000403222 ENST00000382310(uc011alb.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat OSBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBP2 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-519a hsa-miR-890 hsa-miR-124 hsa-miR-372 hsa-miR-637 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OSBP2
    Predesigned siRNA for gene silencing in human, mouse, rat OSBP2
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    GenScript: all cDNA clones in your preferred vector: OSBP2 (NM_030758)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OSBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBP2
      QuantiTect SYBR Green Assays in human, mouse, rat OSBP2
      QuantiFast Probe-based Assays in human, mouse, rat OSBP2

    Additional mRNA sequence: 

    AB051451.2 AF288741.1 AF323731.1 AK093196.1 AK097581.1 AK131374.1 AK294007.1 AK296354.1 
    AK296525.1 AK300323.1 BC004340.1 BC018025.2 BC118914.2 

    18 DOTS entries:

    DT.120656856  DT.451520  DT.92422435  DT.100736883  DT.100774875  DT.120657019  DT.97791663  DT.92422434 
    DT.99930891  DT.100742998  DT.120656874  DT.92422436  DT.120656865  DT.120656894  DT.433692  DT.97843726 
    DT.120656979  DT.92422444 

    Selected AceView cDNA sequences (see all 159):

    BI767725 AB051451 BM693884 BM710008 CR613311 AI983354 NM_001003812 BF438867 
    BQ186605 T30229 BC004340 NM_030758 BQ639297 BM704295 CR625576 AI692389 
    H62631 Z39423 AI701564 CB054211 AF323731 BM453423 CF126411 BF061746 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSBP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:        -                                                                                 
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for OSBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OSBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACTGACC
    OSBP2 Expression
    About this image


    OSBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    OSBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517546

    UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
    Tissue specificity: Expressed mainly in retina, testis, and fetal liver

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbp21 , 5 oxysterol binding protein 21, 5 85.42(n)1
    84.24(a)1
      11 (2.60 cM)5
    743091  NM_152818.21  NP_690031.21 
     37037315 
    chicken
    (Gallus gallus)
    Aves OSBP21 oxysterol binding protein 2 76.24(n)
    74.66(a)
      417002  XM_415293.4  XP_415293.4 
    lizard
    (Anolis carolinensis)
    Reptilia OSBP26
    oxysterol binding protein 2
    69(a)
    1 ↔ 1
    GL343417.1(203202-232218)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia osbp21 oxysterol binding protein 2 69(n)
    73.35(a)
      100491200  XM_002931706.2  XP_002931752.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196622 Transcribed sequence with moderate similarity to protein more 75.48(n)    AL914340.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Osbp1 , 3 oxysterol binding3
    Oxysterol binding protein1
    44(a)3
    57.63(n)1
    51.4(a)1
      96B103
    429851  NM_057923.41  NP_477271.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.17a3
    obr-11
    obr-11 44(a)
    (best of 2)3
    52.87(n)1
    49.79(a)1
      III(11329152-11342496)3
    1765551  NM_001268188.11  NP_001255117.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OSH2(YDL019C)4 Member of an oxysterol-binding protein family with more   --   4(421514-417663) 851543  NP_010265.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORP1C1 ORP1C 49.42(n)
    44.74(a)
      826368  NM_179012.2  NP_849343.2 


    ENSEMBL Gene Tree for OSBP2 (if available)
    TreeFam Gene Tree for OSBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OSBP2 gene
    OSBPL1A2  OSBP2  OSBPL32  OSBPL72  OSBPL22  OSBPL62  
    3 SIMAP similar genes for OSBP2 using alignment to 16 protein entries:     OSBP2_HUMAN (see all proteins):
    OSBP    OSBPL1A    OSBPL2

    Find genes that share paralogs with OSBP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OSBP2 (see all 4120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105603621,2
    C--14213095(+) aagcc-/AActtat 1 -- int10--------
    rs1363911,2
    C--15029885(-) TATAT-/ATTTCCT 1 -- int10--------
    rs106183861,2
    C--15173000(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs1494216881,2
    --31088832(+) ACACAC/TCACCA 1 -- us2k10--------
    rs1809651461,2
    --31088922(+) TGCCTA/GCCTCG 1 -- us2k10--------
    rs568452711,2
    C,F--31088926(+) TGCCTC/TGGCCT 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
    rs1851390481,2
    --31088959(+) CATGAA/GCCACC 1 -- us2k10--------
    rs1892162491,2
    --31088964(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1131189251,2
    F--31089068(+) AAACAC/TACACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1423480601,2
    --31089173(+) GCAATC/TACTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OSBP2 (31089769 - 31303811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OSBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724137CNV Deletion23290073
    esv2500485CNV Deletion19546169
    nsv914973CNV Loss21882294
    nsv522377CNV Gain19592680
    nsv524629CNV Gain19592680
    nsv520242CNV Gain+Loss19592680
    nsv914974CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606729    OMIM disorders: --

    1 disease for OSBP2:    
    About MalaCards
    opisthorchiasis


    Find genes that share disorders with OSBP2           About GenesLikeMe

    Genetic Association Database (GAD): OSBP2
    Human Genome Epidemiology (HuGE) Navigator: OSBP2 (5 documents)

    Export disorders for OSBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OSBP2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with OSBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biochemical characterization of a novel oxysterol- binding protein (OSBP2) highly expressed in retina. (PubMed id 11278871)1, 2, 3, 9 Moreira E.F.... Rodriguez I.R. (J. Biol. Chem. 2001)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration. (PubMed id 18294060)1, 4 Torrini M....Mareni C. (Genet. Test. 2007)
    6. Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. (PubMed id 11802775)1, 3 Wang C....Ridgway N.D. (Biochem. J. 2002)
    7. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2 Hirosawa M.... Ohara O. (DNA Res. 2001)
    8. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (J. Lipid Res. 2001)
    9. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    10. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. (PubMed id 23028956)1 Zhou Y....Olkkonen V.M. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23762 HGNC: 8504 AceView: OSBP2 Ensembl:ENSG00000184792 euGenes: HUgn23762
    ECgene: OSBP2 H-InvDB: OSBP2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1664

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OSBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OSBP2 gene:
    Search GeneIP for patents involving OSBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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