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Aliases for OSBP2 Gene

Aliases for OSBP2 Gene

  • Oxysterol Binding Protein 2 2 3
  • ORP4 3 4 6
  • Oxysterol-Binding Protein-Related Protein 4 3 4
  • OSBP-Related Protein 4 3 4
  • KIAA1664 4 6
  • OSBPL4 3 4
  • ORP-4 3 4
  • Oxysterol Binding Protein-Like 1 3
  • Oxysterol-Binding Protein 2 3
  • OSBPL1 3
  • HLM 3

External Ids for OSBP2 Gene

Previous Symbols for OSBP2 Gene

  • OSBPL1

Summaries for OSBP2 Gene

Entrez Gene Summary for OSBP2 Gene

  • The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for OSBP2 Gene

OSBP2 (Oxysterol Binding Protein 2) is a Protein Coding gene. Diseases associated with OSBP2 include opisthorchiasis. GO annotations related to this gene include phospholipid binding and cholesterol binding. An important paralog of this gene is OSBP.

UniProtKB/Swiss-Prot for OSBP2 Gene

  • Binds 7-ketocholesterol

Gene Wiki entry for OSBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBP2 Gene

Genomics for OSBP2 Gene

Genomic Location for OSBP2 Gene

Start:
30,693,782 bp from pter
End:
30,907,824 bp from pter
Size:
214,043 bases
Orientation:
Plus strand

Genomic View for OSBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBP2 Gene

Regulatory Elements for OSBP2 Gene

Proteins for OSBP2 Gene

  • Protein details for OSBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969R2-OSBP2_HUMAN
    Recommended name:
    Oxysterol-binding protein 2
    Protein Accession:
    Q969R2
    Secondary Accessions:
    • B0QYG1
    • B4DK24
    • B4DKE4
    • B4DTR3
    • F5H2A3
    • O60396
    • Q0VF99
    • Q8NA37
    • Q9BY96
    • Q9BZF0

    Protein attributes for OSBP2 Gene

    Size:
    916 amino acids
    Molecular mass:
    101266 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK56864.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK56865.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB33334.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OSBP2 Gene

neXtProt entry for OSBP2 Gene

Proteomics data for OSBP2 Gene at MOPED

Post-translational modifications for OSBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSBP2 Gene

Domains for OSBP2 Gene

Gene Families for OSBP2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBP2 Gene

UniProtKB/Swiss-Prot:

OSBP2_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q969R2
Family:
  • Belongs to the OSBP family.:
    • Q969R2
genes like me logo Genes that share domains with OSBP2: view

Function for OSBP2 Gene

Molecular function for OSBP2 Gene

UniProtKB/Swiss-Prot Function: Binds 7-ketocholesterol

Gene Ontology (GO) - Molecular Function for OSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015485 cholesterol binding IDA 17428193
genes like me logo Genes that share ontologies with OSBP2: view

miRNA for OSBP2 Gene

miRTarBase miRNAs that target OSBP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBP2 Gene

Localization for OSBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBP2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBP2 Gene COMPARTMENTS Subcellular localization image for OSBP2 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OSBP2: view

Pathways for OSBP2 Gene

SuperPathways for OSBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with OSBP2: view

No data available for Pathways by source for OSBP2 Gene

Transcripts for OSBP2 Gene

Unigene Clusters for OSBP2 Gene

Oxysterol binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for OSBP2 Gene

GeneLoc Exon Structure for
OSBP2
ECgene alternative splicing isoforms for
OSBP2

Expression for OSBP2 Gene

mRNA expression in normal human tissues for OSBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSBP2 Gene

This gene is overexpressed in Whole Blood (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OSBP2 Gene

SOURCE GeneReport for Unigene cluster for OSBP2 Gene Hs.517546

mRNA Expression by UniProt/SwissProt for OSBP2 Gene

Q969R2-OSBP2_HUMAN
Tissue specificity: Expressed mainly in retina, testis, and fetal liver.
genes like me logo Genes that share expressions with OSBP2: view

Orthologs for OSBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBP2 36
  • 99.33 (n)
  • 99.43 (a)
OSBP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBP2 36
  • 85.57 (n)
  • 82.49 (a)
OSBP2 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBP2 36
  • 89.18 (n)
  • 88.38 (a)
OSBP2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbp2 36
  • 85.42 (n)
  • 84.24 (a)
Osbp2 16
Osbp2 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBP2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBP2 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbp2 36
  • 86.69 (n)
  • 86.13 (a)
chicken
(Gallus gallus)
Aves OSBP2 36
  • 76.24 (n)
  • 74.66 (a)
OSBP2 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBP2 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbp2 36
  • 69 (n)
  • 73.35 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19662 36
osbp2 37
  • 66 (a)
OneToMany
OSBP2 (1 of 2) 37
  • 68 (a)
OneToMany
si:ch211-106a19.1 36
  • 69.76 (n)
  • 71.87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010893 36
  • 39.94 (n)
  • 24.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Osbp 36
  • 57.63 (n)
  • 51.4 (a)
Osbp 37
  • 46 (a)
OneToMany
Osbp 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-1 36
  • 52.87 (n)
  • 49.79 (a)
obr-1 37
  • 40 (a)
OneToMany
Y47D3A.17b 38
  • 43 (a)
Y47D3A.17a 38
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH2 37
  • 19 (a)
ManyToMany
OSH2 39
SWH1 37
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ORP1C 36
  • 49.42 (n)
  • 44.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 57 (a)
OneToMany
Species with no ortholog for OSBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBP2 Gene

ENSEMBL:
Gene Tree for OSBP2 (if available)
TreeFam:
Gene Tree for OSBP2 (if available)

Paralogs for OSBP2 Gene

Paralogs for OSBP2 Gene

genes like me logo Genes that share paralogs with OSBP2: view

Variants for OSBP2 Gene

Sequence variations from dbSNP and Humsavar for OSBP2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4443 -- 30,819,903(-) AGGGC(A/C)GAGGA intron-variant
rs4444 -- 30,809,347(-) CTCGC(A/G)GTACT intron-variant
rs8004 -- 30,907,721(-) AGCCC(C/T)AGTGG utr-variant-3-prime
rs79357 -- 30,781,370(-) AAGGT(G/T)GGGGG intron-variant
rs136214 -- 30,837,661(-) ACGAG(C/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBP2 Gene

Variant ID Type Subtype PubMed ID
nsv522377 CNV Gain 19592680
nsv914973 CNV Loss 21882294
esv2724137 CNV Deletion 23290073
nsv520242 CNV Gain+Loss 19592680
nsv524629 CNV Gain 19592680
nsv914974 CNV Gain+Loss 21882294
esv2500485 CNV Deletion 19546169

Relevant External Links for OSBP2 Gene

HapMap Linkage Disequilibrium report
OSBP2

Disorders for OSBP2 Gene

(1) MalaCards Diseases for OSBP2 Gene

Search for OSBP2 Gene in MalaCards »

Relevant External Links for OSBP2

Genetic Association Database (GAD)
OSBP2
Human Genome Epidemiology (HuGE) Navigator
OSBP2
genes like me logo Genes that share disorders with OSBP2: view

No data available for UniProtKB/Swiss-Prot for OSBP2 Gene

Publications for OSBP2 Gene

  1. Molecular and biochemical characterization of a novel oxysterol- binding protein (OSBP2) highly expressed in retina. (PMID: 11278871) Moreira E.F. … Rodriguez I.R. (J. Biol. Chem. 2001) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 3 4
  4. The OSBP-related protein family in humans. (PMID: 11483621) Lehto M. … Olkkonen V.M. (J. Lipid Res. 2001) 3 4
  5. Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. (PMID: 11802775) Wang C. … Ridgway N.D. (Biochem. J. 2002) 2 3

Products for OSBP2 Gene

Sources for OSBP2 Gene

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