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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSBP2 Gene

protein-coding   GIFtS: 55
GCID: GC22P031089

oxysterol binding protein 2


(Previous symbol: OSBPL1)
 Explore 8 diseases affiliated with
OSBP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OSBP2    

Aliases
for OSBP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Oxysterol Binding Protein 21 2     OSBPL42 3
ORP41 2 3 5     OSBP-Related Protein 42 3
ORP-41 2 3     Oxysterol Binding Protein-Like 12
KIAA16641 3 5     Oxysterol Binding Protein-Related Protein 42
OSBPL11 2     Oxysterol-Binding Protein 22
Oxysterol-Binding Protein-Related Protein 42 3     

External Ids:    HGNC: 85041   Entrez Gene: 237622   Ensembl: ENSG000001847927   OMIM: 6067295   UniProtKB: Q969R23   

Export aliases for OSBP2 gene to outside databases

Previous GC identifers: GC22P027786 GC22P029415 GC22P014053


Summaries
for OSBP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OSBP2:
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein
encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols
such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been
observed but have not been fully characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
Function: Binds 7-ketocholesterol

Gene Wiki entry for OSBP2


Genomic Views
for OSBP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSBP2 gene promoter:
         AhR   Pax-5   Pax-6   SREBP-1c   E47   SREBP-1b   Pax-3   SREBP-1a   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OSBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OSBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

OSBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBP2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031089:  view genomic region     (about GC identifiers)

Start:
 31,089,769 bp from pter      End:
 31,303,811 bp from pter
Size:
 214,043 bases      Orientation:
 plus strand

Proteins
for OSBP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2 (See protein sequence)
Recommended Name: Oxysterol-binding protein 2  
Size: 916 amino acids; 101266 Da
Subcellular location: Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAK56864.1; Type=Erroneous initiation; Sequence=AAK56865.1; Type=Erroneous initiation;
Sequence=BAB33334.2; Type=Erroneous initiation;
Secondary accessions: B0QYG1 O60396 Q9BY96 Q9BZF0

Explore the universe of human proteins at neXtProt for OSBP2: NX_Q969R2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969R2

    • OSBP2 Protein expression data from MOPED and PaxDb:    About this image 
    OSBP2 Protein Expression
    REFSEQ proteins: NP_110385.1  
    ENSEMBL proteins: 
     ENSP00000411052   ENSP00000385237   ENSP00000332576   ENSP00000392080   ENSP00000411497  
     ENSP00000385254   ENSP00000388575   ENSP00000409011   ENSP00000401776   ENSP00000415274  
     ENSP00000409838   ENSP00000392362   ENSP00000384213   ENSP00000371747   ENSP00000389200  
     ENSP00000438713  

    Human Recombinant Protein Products for OSBP2: 
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    OriGene Protein Over-expression Lysate: OSBP2
    OriGene Custom Protein Services for OSBP2 
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    Novus Biologicals OSBP2 Protein
    Novus Biologicals OSBP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OSBP2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    OSBP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OSBP2

    Protein Domains /
    Families
    for OSBP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OSBP2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q969R2

    ProtoNet protein and cluster: Q969R2

    2 Blocks protein families:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    Function
    for OSBP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSBP2_HUMAN, Q969R2
    Function: Binds 7-ketocholesterol

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--
    GO:0015485cholesterol binding IDA17428193
         
    OSBP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OSBP2 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: OSBP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBP2
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBP2 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-519a hsa-miR-890 hsa-miR-124 hsa-miR-372 hsa-miR-637 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: OSBP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBP2 (see all 6)
    Browse OriGene siRNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against OSBP2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OSBP2
    Sirion Biotech Customized adenovirus for overexpression of OSBP2 
    Sirion Biotech Customized adenovirus for potent knockdown of OSBP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OSBP2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for OSBP2
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP2


    Pathways & Interactions
    for OSBP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSBP2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/44 Interacting proteins for OSBP2 (Q969R22, 3 ENSP000003325764) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNT1P138052, 3, ENSP000002919014MINT-8275006 I2D: score=2 STRING: ENSP00000291901
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    VIMP086703, ENSP000002242374I2D: score=2 STRING: ENSP00000224237
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    OSBP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OSBP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSBP2
    Search CenterWatch for drugs/clinical trials and news about OSBP2 

    Transcripts
    for OSBP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OSBP2 gene: 
    NM_030758.3  

    Unigene Cluster for OSBP2:

    Oxysterol binding protein 2
    Hs.517546  [show with all ESTs]
    Unigene Representative Sequence: NM_030758
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000438716 ENST00000407373(uc010gwc.1) ENST00000332585(uc011ala.1 uc003aix.1 uc003aiy.1 uc003aiz.1 uc003aja.1 uc011ald.1 uc010gwd.1)
    ENST00000446658 ENST00000477355 ENST00000445781 ENST00000401475 ENST00000464341
    ENST00000496367 ENST00000424224 ENST00000454145 ENST00000453621 ENST00000431368
    ENST00000452656 ENST00000496575 ENST00000433183 ENST00000403222 ENST00000382310(uc011alb.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: OSBP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBP2
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBP2 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-519a hsa-miR-890 hsa-miR-124 hsa-miR-372 hsa-miR-637 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: OSBP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OSBP2 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against OSBP2 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OSBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OSBP2 (NM_030758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBP2

    Additional cDNA sequence: 

    AB051451.2 AF288741.1 AF323731.1 AK093196.1 AK097581.1 AK131374.1 AK294007.1 AK296354.1 
    AK296525.1 AK300323.1 BC004340.1 BC018025.2 BC118914.2 

    18 DOTS entries:

    DT.120656856  DT.451520  DT.92422435  DT.100736883  DT.100774875  DT.120657019  DT.97791663  DT.92422434 
    DT.99930891  DT.100742998  DT.120656874  DT.92422436  DT.120656865  DT.120656894  DT.433692  DT.97843726 
    DT.120656979  DT.92422444 

    24/159 AceView cDNA sequences (see all 159):

    Z39423 BI767725 CB054211 AI701564 AF323731 BX953331 BQ422860 AK093196 
    BQ638465 AX747984 BF061746 BM453423 AV708998 CF126411 BM710008 BM693884 
    NM_001003812 CR613311 BQ186605 BF438867 AI983354 T30229 NM_030758 BQ639297 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSBP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:        -                                                                                 
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for OSBP2

    Expression
    for OSBP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCACTGACC
    OSBP2 Expression
    About this image

    OSBP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OSBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSBP2

    SOURCE GeneReport for Unigene cluster: Hs.517546

    UniProtKB/Swiss-Prot: OSBP2_HUMAN, Q969R2
    Tissue specificity: Expressed mainly in retina, testis, and fetal liver

        SABiosciences Custom PCR Arrays for OSBP2
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    In Situ
    Assay Products:     
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    Orthologs
    for OSBP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBP2 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OSBP21 oxysterol binding protein 2 74.97(n)
    73.78(a)    		   417002  XM_415293.3  XP_415293.3 
    lizard
    (Anolis carolinensis)    		 Reptilia OSBP26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343417.1(203472-228377)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.196622 Transcribed sequence with moderate similarity to protein more 75.48(n)    AL914340.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Osbp1 , 3 oxysterol binding3
    Oxysterol binding protein1    		 44(a)3
    57.99(n)1
    51.39(a)1    		   96B103
    429851  NM_057923.31  NP_477271.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y47D3A.17a3
    obr-11    		 Protein OBR-11 44(a)
    (best of 2)3
    52.74(n)1
    49.29(a)1    		   III(11329152-11342496)3
    1765551  NM_067047.31  NP_499448.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes OSH2(YDL019C)4
    OSH21    		 Member of an oxysterol-binding protein family with more4
    Osh2p1    		 44.46(n)1
    37.42(a)1    		   4(421514-417663)4
    8515431, 4  NP_010265.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ORP2B1 OSBP(oxysterol binding protein)-related protein 2B 44.15(n)
    36.36(a)    		   826858  NM_117316.2  NP_192983.2 
    rice
    (Oryza sativa)    		 Liliopsida Os08g01549001 hypothetical protein 46.36(n)
    37.05(a)    		   4344687  NM_001067552.1  NP_001061017.1 


    ENSEMBL Gene Tree for OSBP2 (if available)
    TreeFam Gene Tree for OSBP2 (if available) 

    Paralogs
    for OSBP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OSBP2 gene
    OSBP2  OSBPL1A2  OSBPL32  OSBPL72  OSBPL22  OSBPL62  
    3 SIMAP similar genes for OSBP2 using alignment to 16 protein entries:     OSBP2_HUMAN (see all proteins):
    OSBP    OSBPL1A    OSBPL2

    OSBP2 for paralogs           About GeneDecksing



    Genomic Variants
    for OSBP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3525 NCBI SNPs in OSBP2 are shown (see all 3525)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1494216881,2
    		--31088832(+) ACACAC/TCACCA 1 -- us2k10--------
    rs1809651461,2
    		--31088922(+) TGCCTA/GCCTCG 1 -- us2k10--------
    rs568452711,2
    		C,F--31088926(+) TGCCTC/TGGCCT 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
    rs1851390481,2
    		--31088959(+) CATGAA/GCCACC 1 -- us2k10--------
    rs1892162491,2
    		--31088964(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1131189251,2
    		--31089068(+) AAACAC/TACACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1423480601,2
    		--31089173(+) GCAATC/TACTTT 1 -- us2k10--------
    rs1821411301,2
    		--31089198(+) CACCAC/TGCTGA 1 -- us2k10--------
    rs1459512141,2
    		--31089226(+) CATACA/GTATGA 1 -- us2k10--------
    rs96090521,2
    		C,F,H--31089395(+) AGGACC/TTTCCA 1 -- us2k17Minor allele frequency- T:0.00NS EA NA 872

    HapMap Linkage Disequilibrium report for OSBP2 (31089769 - 31303811 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for OSBP2
         2 CNVs: 50848 103151

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    Disorders / Diseases
    for OSBP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OSBP2 for disorders           About GeneDecksing

    OMIM gene information: 606729    OMIM disorders: --

    8 diseases for OSBP2:    About MalaCards
    age related macular degeneration    macular degeneration    opisthorchiasis    chronic myeloid leukemia
    myeloid leukemia    cholesterol    leukemia    malaria

    Human Genome Epidemiology (HuGE) Navigator: OSBP2 (5 documents)

    Export disorders for OSBP2 gene to outside databases

    Publications
    for OSBP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSBP2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with OSBP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. (PubMed id 11278871)1, 2, 3, 9 Moreira E.F....Rodriguez I.R. (2001)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    3. Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. (PubMed id 11802775)1, 3 Wang C....Ridgway N.D. (2002)
    4. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2 Hirosawa M....Ohara O. (2001)
    5. The OSBP-related protein family in humans. (PubMed id 11483621)1, 2 Lehto M.... Olkkonen V.M. (2001)
    6. Expression of oxysterol binding protein isoforms in op isthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tu mor metastasis. (PubMed id 21763455)1 Loilome W....Yongvanit P. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    External Searches for OSBP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OSBP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23762 HGNC: 8504 AceView: OSBP2 Ensembl:ENSG00000184792 euGenes: HUgn23762
    ECgene: OSBP2 H-InvDB: OSBP2

    Other Databases showing OSBP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1664

    Specialized Databases showing OSBP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSBP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OSBP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OSBP2 gene:
    Search GeneIP for patents involving OSBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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