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Aliases for OSBP Gene

Aliases for OSBP Gene

  • Oxysterol Binding Protein 2 3
  • OSBP1 3 4
  • Oxysterol-Binding Protein 1 3

External Ids for OSBP Gene

Summaries for OSBP Gene

Entrez Gene Summary for OSBP Gene

  • Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBP Gene

OSBP (Oxysterol Binding Protein) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Metabolism. GO annotations related to this gene include phospholipid binding and oxysterol binding. An important paralog of this gene is OSBPL7.

UniProtKB/Swiss-Prot for OSBP Gene

  • Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.

Gene Wiki entry for OSBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBP Gene

Genomics for OSBP Gene

Genomic Location for OSBP Gene

Start:
59,574,398 bp from pter
End:
59,616,144 bp from pter
Size:
41,747 bases
Orientation:
Minus strand

Genomic View for OSBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBP Gene

Regulatory Elements for OSBP Gene

Proteins for OSBP Gene

  • Protein details for OSBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22059-OSBP1_HUMAN
    Recommended name:
    Oxysterol-binding protein 1
    Protein Accession:
    P22059
    Secondary Accessions:
    • Q6P524

    Protein attributes for OSBP Gene

    Size:
    807 amino acids
    Molecular mass:
    89421 Da
    Quaternary structure:
    • Homodimer or homotrimer. Interacts with VAPA.
    SequenceCaution:
    • Sequence=AAH63121.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OSBP Gene

neXtProt entry for OSBP Gene

Proteomics data for OSBP Gene at MOPED

Post-translational modifications for OSBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSBP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OSBP Gene

Domains for OSBP Gene

Gene Families for OSBP Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • OSBP :Oxysterol binding proteins

Protein Domains for OSBP Gene

UniProtKB/Swiss-Prot:

OSBP1_HUMAN
Domain:
  • The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.:
    • P22059
  • The second coiled-coil domain is required for interaction with the tyrosine phosphatase.:
    • P22059
  • Contains 1 PH domain.:
    • P22059
Family:
  • Belongs to the OSBP family.:
    • P22059
genes like me logo Genes that share domains with OSBP: view

Function for OSBP Gene

Molecular function for OSBP Gene

GENATLAS Biochemistry: oxysterol binding protein,involved in the regulation of cholesterol metabolism
UniProtKB/Swiss-Prot Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.

Gene Ontology (GO) - Molecular Function for OSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988961
GO:0008142 oxysterol binding TAS 1970801
GO:0019904 protein domain specific binding IPI 20178991
genes like me logo Genes that share ontologies with OSBP: view

miRNA for OSBP Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OSBP Gene

Localization for OSBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBP Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSBP Gene COMPARTMENTS Subcellular localization image for OSBP gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 3
endoplasmic reticulum 2
endosome 2
peroxisome 2
plasma membrane 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for OSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with OSBP: view

Pathways for OSBP Gene

genes like me logo Genes that share pathways with OSBP: view

Pathways by source for OSBP Gene

Gene Ontology (GO) - Biological Process for OSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0044128 positive regulation of growth of symbiont in host IMP 21988961
genes like me logo Genes that share ontologies with OSBP: view

Compounds for OSBP Gene

(1) HMDB Compounds for OSBP Gene

Compound Synonyms Cas Number PubMed IDs
25-Hydroxycholesterol
  • (beta)-cholest-5-ene-3-25-diol
2140-46-7

(9) Novoseek inferred chemical compound relationships for OSBP Gene

Compound -log(P) Hits PubMed IDs
25-hydroxycholesterol 90.2 19
sterol 77.9 19
cholesterol 64 33
3-hydroxy-3-methylglutaryl-coa 53 1
lipid 52 13
genes like me logo Genes that share compounds with OSBP: view

Transcripts for OSBP Gene

mRNA/cDNA for OSBP Gene

Unigene Clusters for OSBP Gene

Oxysterol binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for OSBP Gene

GeneLoc Exon Structure for
OSBP
ECgene alternative splicing isoforms for
OSBP

Expression for OSBP Gene

mRNA expression in normal human tissues for OSBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSBP Gene

SOURCE GeneReport for Unigene cluster for OSBP Gene Hs.597091

mRNA Expression by UniProt/SwissProt for OSBP Gene

P22059-OSBP1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with OSBP: view

Orthologs for OSBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBP 36
  • 99.79 (n)
  • 99.88 (a)
OSBP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSBP 36
  • 84.49 (n)
  • 93.05 (a)
OSBP 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSBP 36
  • 90.14 (n)
  • 94.98 (a)
OSBP 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osbp 36
  • 88.78 (n)
  • 93.66 (a)
Osbp 16
Osbp 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSBP 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBP 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbp 36
  • 92.08 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves LOC101747893 36
  • 78.17 (n)
  • 91.04 (a)
OSBP 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBP 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osbp 36
  • 70.78 (n)
  • 81.28 (a)
zebrafish
(Danio rerio)
Actinopterygii osbp 36
  • 68.62 (n)
  • 75.66 (a)
osbp 37
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Osbp 37
  • 48 (a)
OneToMany
Osbp 38
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea obr-1 37
  • 38 (a)
OneToMany
Y47D3A.17b 38
  • 45 (a)
Y47D3A.17a 38
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OSH2 37
  • 19 (a)
ManyToMany
SWH1 37
  • 20 (a)
ManyToMany
SWH1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons ORP2A 36
  • 46.51 (n)
  • 37.01 (a)
rice
(Oryza sativa)
Liliopsida Os08g0154900 36
  • 46.26 (n)
  • 38.13 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00579 36
  • 47.06 (n)
  • 37.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2F12.05c 36
  • 51.5 (n)
  • 45.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 57 (a)
OneToMany
Species with no ortholog for OSBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSBP Gene

ENSEMBL:
Gene Tree for OSBP (if available)
TreeFam:
Gene Tree for OSBP (if available)

Paralogs for OSBP Gene

Paralogs for OSBP Gene

Selected SIMAP similar genes for OSBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OSBP: view

Variants for OSBP Gene

Sequence variations from dbSNP and Humsavar for OSBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8280 -- 59,574,705(+) CATAA(C/T)CCCTG utr-variant-3-prime
rs473490 -- 59,590,470(+) tatgc(C/T)tagtt intron-variant
rs477160 -- 59,580,987(+) AGATA(C/T)TATCA intron-variant
rs486952 -- 59,577,116(+) CCACA(C/T)CACCA intron-variant
rs488331 -- 59,591,103(+) AATGC(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSBP Gene

Variant ID Type Subtype PubMed ID
esv26905 CNV Loss 19812545

Relevant External Links for OSBP Gene

HapMap Linkage Disequilibrium report
OSBP

Disorders for OSBP Gene

(2) Novoseek inferred disease relationships for OSBP Gene

Disease -log(P) Hits PubMed IDs
solid tumor 16.9 1
atherosclerosis 0 1

Relevant External Links for OSBP

Genetic Association Database (GAD)
OSBP
Human Genome Epidemiology (HuGE) Navigator
OSBP
genes like me logo Genes that share disorders with OSBP: view

No data available for UniProtKB/Swiss-Prot for OSBP Gene

Publications for OSBP Gene

  1. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. (PMID: 1970801) Levanon D. … Goldstein J.L. (Genomics 1990) 3 4 23
  2. OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. (PMID: 15746430) Wang P.-Y. … Anderson R.G.W. (Science 2005) 3 4 23
  3. Molecular and biochemical characterization of a novel oxysterol- binding protein (OSBP2) highly expressed in retina. (PMID: 11278871) Moreira E.F. … Rodriguez I.R. (J. Biol. Chem. 2001) 3 4 23
  4. Electrostatic interaction between oxysterol-binding protein and VAMP- associated protein A revealed by NMR and mutagenesis studies. (PMID: 20178991) Furuita K. … Kojima C. (J. Biol. Chem. 2010) 3 4 23
  5. The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP. (PMID: 18165705) Wang P.Y. … Anderson R.G. (J. Biol. Chem. 2008) 3 23

Products for OSBP Gene

  • Addgene plasmids for OSBP

Sources for OSBP Gene

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