External Ids for OSBP Gene
Previous GeneCards Identifiers for OSBP Gene
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
GeneCards Summary for OSBP Gene
OSBP (Oxysterol Binding Protein) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Metabolism. GO annotations related to this gene include phospholipid binding and oxysterol binding. An important paralog of this gene is OSBPL7.
UniProtKB/Swiss-Prot for OSBP Gene
Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.