Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OSBP Gene

protein-coding   GIFtS: 61
GCID: GC11M059341

Oxysterol Binding Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oxysterol Binding Protein1 2
OSBP12 3
Oxysterol-Binding Protein 12

External Ids:    HGNC: 85031   Entrez Gene: 50072   Ensembl: ENSG000001100487   OMIM: 1670405   UniProtKB: P220593   

Export aliases for OSBP gene to outside databases

Previous GC identifers: GC11M061735 GC11M060855 GC11M059592 GC11M059117 GC11M059098 GC11M055689


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OSBP Gene:
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the
nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase
(provided by RefSeq, Jul 2008)

GeneCards Summary for OSBP Gene: 
OSBP (oxysterol binding protein) is a protein-coding gene. Diseases associated with OSBP include cardiovascular disease risk factor ), and chronic myeloid leukemia. GO annotations related to this gene include phospholipid binding and oxysterol binding. An important paralog of this gene is OSBPL1A.

UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex
with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its
disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability

Gene Wiki entry for OSBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OSBP gene promoter:
         Bach1   CBF-C   MEF-2A   CBF-B   CBF-A   aMEF-2   CP1A   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): OSBP promoter sequence
   Search SABiosciences Chromatin IP Primers for OSBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13

OSBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059341:  view genomic region     (about GC identifiers)

Start:
59,341,871 bp from pter      End:
59,383,617 bp from pter
Size:
41,747 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059 (See protein sequence)
Recommended Name: Oxysterol-binding protein 1  
Size: 807 amino acids; 89421 Da
Subunit: Homodimer or homotrimer. Interacts with VAPA
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to
oxysterols, translocates to the periphery of Golgi membranes
Sequence caution: Sequence=AAH63121.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
1 PDB 3D structure from and Proteopedia for OSBP:
2RR3 (3D)    
Secondary accessions: Q6P524

Explore the universe of human proteins at neXtProt for OSBP: NX_P22059

Explore proteomics data for OSBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22059

  • OSBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OSBP Protein Expression
    REFSEQ proteins: NP_002547.1  
    ENSEMBL proteins: 
     ENSP00000263847   ENSP00000432399  

    Human Recombinant Protein Products for OSBP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OSBP
    OriGene Protein Over-expression Lysate for OSBP
    OriGene MassSpec for OSBP 
    OriGene Custom Protein Services for OSBP
    GenScript Custom Purified and Recombinant Proteins Services for OSBP
    Novus Biologicals OSBP Proteins
    Novus Biologicals OSBP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSBP 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--

    OSBP for ontologies           About GeneDecksing



    OSBP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of OSBP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OSBP
    OriGene Custom Antibody Services for OSBP
    GenScript Custom Superior Antibodies Services for OSBP
    Novus Biologicals OSBP Antibodies
    Abcam antibodies for OSBP
    Cloud-Clone Corp. Antibodies for OSBP 
    ThermoFisher Antibody for OSBP
    LSBio Antibodies in human, mouse, rat for OSBP 

    Assay Products for OSBP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSBP 
    Cloud-Clone Corp. CLIAs for OSBP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry P22059

    ProtoNet protein and cluster: P22059

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
    Domain: The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol
    binding (By similarity)
    Domain: The second coiled-coil domain is required for interaction with the tyrosine phosphatase (By similarity)
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    OSBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSBP1_HUMAN, P22059
    Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex
    with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its
    disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability

         Genatlas biochemistry entry for OSBP:
    oxysterol binding protein,involved in the regulation of cholesterol metabolism

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0008142oxysterol binding TAS1970801
         
    OSBP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OSBP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OSBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OSBP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OSBP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBP
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBP (see all 36):
    hsa-miR-3164 hsa-miR-29a hsa-miR-374a hsa-miR-877* hsa-miR-1244 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSBP
    Sirion Biotech Customized adenovirus for overexpression of OSBP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OSBP (see all 7)
    OriGene ORF clones in mouse, rat for OSBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSBP (NM_002556)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
    Sirion Biotech Customized lentivirus for stable overexpression of OSBP 
                         Customized lentivirus expression plasmids for stable overexpression of OSBP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSBP
    Search LifeMap BioReagents cell lines for OSBP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OSBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/45 Interacting proteins for OSBP (P220593 ENSP000002638474) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAPAQ9P0L03, ENSP000003456564I2D: score=3 STRING: ENSP00000345656
    OSBP2Q969R23I2D: score=5 
    EEF1A1P681043I2D: score=4 
    SPATA5Q8NB903I2D: score=4 
    EEF2P136393I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    OSBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OSBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OSBP (OSBP1)

    1 HMDB Compound for OSBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    25-Hydroxycholesterol(beta)-cholest-5-ene-3-25-diol (see all 8)2140-46-7--

    9 Novoseek inferred chemical compound relationships for OSBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    25-hydroxycholesterol 90.2 27 16098143 (6), 9337870 (3), 8217873 (2), 18165705 (2) (see all 10)
    sterol 77.9 33 19129476 (3), 19207211 (3), 16876994 (2), 16571669 (2) (see all 12)
    cholesterol 64 47 9337870 (5), 15746430 (5), 16098143 (4), 18165705 (4) (see all 17)
    3-hydroxy-3-methylglutaryl-coa 53 1 10364480 (1)
    lipid 52 19 15166789 (2), 20224571 (1), 18614794 (1), 15746430 (1) (see all 12)
    ceramide 48.7 11 16571669 (5), 19129476 (1), 15907394 (1), 16806880 (1)
    phosphatidylinositol 38.8 4 15635101 (1), 18614794 (1), 9268346 (1)
    phosphatidylcholine 21.3 1 18614794 (1)
    tyrosine 0 1 15746430 (1)

    Search CenterWatch for drugs/clinical trials and news about OSBP / OSBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OSBP gene: 
    NM_002556.2  

    Unigene Cluster for OSBP:

    Oxysterol binding protein
    Hs.597091  [show with all ESTs]
    Unigene Representative Sequence: AF185696
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263847(uc009ymr.1 uc001noc.1) ENST00000525357 ENST00000528903

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OSBP
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate OSBP (see all 36):
    hsa-miR-3164 hsa-miR-29a hsa-miR-374a hsa-miR-877* hsa-miR-1244 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OSBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBP
    Clone
    Products:
         
    OriGene clones in human, mouse for OSBP (see all 7)
    OriGene ORF clones in mouse, rat for OSBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSBP (NM_002556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
    Sirion Biotech Customized lentivirus for stable overexpression of OSBP 
                         Customized lentivirus expression plasmids for stable overexpression of OSBP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBP

    Additional mRNA sequence: 

    AF185696.1 AK299071.1 AK310538.1 BC011581.1 BC017975.1 BC051350.1 BC063121.1 M86917.1 

    7 DOTS entries:

    DT.416931  DT.92414555  DT.95278062  DT.100823830  DT.95176337  DT.120713158  DT.422599 

    24/299 AceView cDNA sequences (see all 299):

    AA234406 CK820675 AA836377 BF062656 NM_002556 AW298003 BM971685 CK725180 
    BE503621 AL705332 AI742703 BM980178 BM725153 AA704451 BM768077 AW052144 
    CR592861 AI590293 BX496348 AL552124 BQ682579 CB134587 BQ877220 AU185459 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSBP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                                                    -                                                   
    SP2:                                                                    -     -                                             
    SP3:                                                                    -     -                                             
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for OSBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OSBP expression in normal human tissues (normalized intensities)      OSBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACAAAAC
    OSBP Expression
    About this image


    OSBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See OSBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OSBP

    SOURCE GeneReport for Unigene cluster: Hs.597091

    UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for OSBP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OSBP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBP gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbp1 , 5 oxysterol binding protein1, 5 90.52(n)1
    96.15(a)1
      19 (8.58 cM)5
    763031  NM_001033174.11  NP_001028346.11 
     119658445 
    chicken
    (Gallus gallus)
    Aves OSBP1 oxysterol binding protein 78.15(n)
    91.09(a)
      426566  XM_424206.3  XP_424206.3 
    lizard
    (Anolis carolinensis)
    Reptilia OSBP6
    Oxysterol-binding protein
    90(a)
    1 ↔ 1
    1(91002190-91043929)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ734939.12   -- 75.84(n)    BQ734939.1 
    zebrafish
    (Danio rerio)
    Actinopterygii osbp1 oxysterol binding protein 68.32(n)
    75.41(a)
      564372  NM_001145585.1  NP_001139057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Osbp3 oxysterol binding 45(a)   96B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.17a3   -- 46(a)
    (best of 2)
      III(11329152-11342496)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWH1(YAR042W)4
    SWH11
    Protein similar to mammalian oxysterol-binding protein; more4
    Swh1p1
    47.23(n)1
    36.68(a)1
      1(192619-196185)4
    8512861, 4  NP_009421.31, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORP1D1 oxysterol binding protein-related protein 1D 45.74(n)
    36.28(a)
      837875  NM_001198051.1  NP_001184980.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g02856001 hypothetical protein 45.27(n)
    36.56(a)
      4351995  NM_001073118.1  NP_001066586.1 


    ENSEMBL Gene Tree for OSBP (if available)
    TreeFam Gene Tree for OSBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OSBP gene
    OSBPL1A2  OSBPL32  OSBPL72  OSBP22  OSBPL22  OSBPL62  
    3 SIMAP similar genes for OSBP using alignment to 2 protein entries:     OSBP1_HUMAN (see all proteins):
    OSBP2    OSBPL2    OSBPL1A

    OSBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 SNPs in OSBP are shown (see all 798)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360994
    A colorectal cancer sample4--see VAR_0360992 D A mis40--------
    rs1916714761,2
    --59341390(+) TACTTC/GGGGAG 1 -- ds50010--------
    rs1380506491,2
    --59341417(+) CGCTTC/GAGCCT 1 -- ds50010--------
    rs5030181,2
    C,F,A,H--59341429(+) GGAGGC/TGGATG 1 -- ds500119Minor allele frequency- T:0.08NS EA NA WA CSA 797
    rs1416186801,2
    --59341765(+) CTTCTA/GGGCGC 1 -- ds50010--------
    rs1505229581,2
    --59341768(+) CTGGGC/TGCTCA 1 -- ds50010--------
    rs1840013231,2
    --59342024(+) AATCTA/GATTGG 1 -- ut310--------
    rs57921511,2
    C--59342128(+) CCCCGG/-ATGAG 1 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs82801,2
    C,F,A,H--59342178(+) CATAAT/CCCCTG 1 -- ut31 ese327Minor allele frequency- C:0.20MN NA NS EA WA CSA 2851
    rs763136181,2
    C,F--59342271(+) AGGAAG/AGGATA 1 -- ut311Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for OSBP (59341871 - 59383617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OSBP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26905CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OSBP
    DNA2.0 Custom Variant and Variant Library Synthesis for OSBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 167040    OMIM disorders: --

    9 diseases for OSBP:    About MalaCards
    cardiovascular disease risk factor )    chronic myeloid leukemia    atherosclerosis    hepatitis c
    myeloid leukemia    obesity    hypertension    hepatitis
    leukemia


    OSBP for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for OSBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 16.9 1 11295104 (1)
    atherosclerosis 0 1 15768828 (1)

    Genetic Association Database (GAD): OSBP
    Human Genome Epidemiology (HuGE) Navigator: OSBP (5 documents)

    Export disorders for OSBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OSBP gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with OSBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. (PubMed id 1970801)1, 2, 9 Levanon D.... Goldstein J.L. (1990)
    2. OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. (PubMed id 15746430)1, 2, 9 Wang P.-Y.... Anderson R.G.W. (2005)
    3. Electrostatic interaction between oxysterol-binding p rotein and VAMP-associated protein A revealed by NMR and mutagenesis studies. (PubMed id 20178991)1, 2, 9 Furuita K....Kojima C. (2010)
    4. Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. (PubMed id 11278871)1, 2, 9 Moreira E.F....Rodriguez I.R. (2001)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. (PubMed id 16571669)1, 9 Perry R.J. and Ridgway N.D. (2006)
    9. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PubMed id 10588946)1, 9 Laitinen S....Ikonen E. (1999)
    10. The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP. (PubMed id 18165705)1, 9 Wang P.Y....Anderson R.G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5007 HGNC: 8503 AceView: OSBP Ensembl:ENSG00000110048 euGenes: HUgn5007
    ECgene: OSBP H-InvDB: OSBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OSBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OSBP gene:
    Search GeneIP for patents involving OSBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of OSBP
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OSBP   OriGene RNAi products in human, mouse, rat for OSBP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OSBP  
     OriGene MassSpec something-or-other for OSBP   OriGene clones in human, mouse for OSBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for OSBP   OriGene Purified Protein for OSBP  
     OriGene ORF clones in mouse, rat for OSBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OSBP   OriGene Custom Protein Services for OSBP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OSBP
     QIAGEN SeqTarget long-range PCR primers for resequencing OSBP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OSBP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OSBP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OSBP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OSBP
     GenScript Custom Purified and Recombinant Proteins Services for OSBP GenScript cDNA clones with any tag delivered in your preferred vector for OSBP
     GenScript Custom Assay Services for OSBP GenScript Custom Superior Antibodies Services for OSBP
     GenScript Custom overexpressing Cell Line Services for OSBP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OSBP promoter
     Search Chromatin IP Primers for OSBP
     RT2 qPCR Primer Assay in human, mouse, rat OSBP
     GNC Network for OSBP
     SABiosciences Custom PCR Arrays for OSBP
     Search Tocris compounds for OSBP (OSBP1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OSBP antibodies
     OSBP proteins
     OSBP lysates
     Antibodies for OSBP
     See all of Abcam's Antibodies, Kits and Proteins for OSBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OSBP
     Antibodies for OSBP
     ELISAs for OSBP
     CLIAs for OSBP
     Search LifeMap BioReagents cell lines for OSBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP
     SwitchGear 3'UTR luciferase reporter plasmids for OSBP
     SwitchGear Promoter luciferase reporter plasmids for OSBP
     ThermoFisher Antibody for OSBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OSBP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OSBP
    Customized:
     lentivirus for stable overexpression of OSBP
     lentivirus expression plasmids for stable overexpression of OSBP
     adenovirus for overexpression of OSBP
     LSBio Antibodies in human, mouse, rat for OSBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OSBP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4