Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OSBP Gene

protein-coding   GIFtS: 63
GCID: GC11M059341

Oxysterol Binding Protein

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Oxysterol Binding Protein1 2
OSBP12 3
Oxysterol-Binding Protein 12

External Ids:    HGNC: 85031   Entrez Gene: 50072   Ensembl: ENSG000001100487   OMIM: 1670405   UniProtKB: P220593   

Export aliases for OSBP gene to outside databases

Previous GC identifers: GC11M061735 GC11M060855 GC11M059592 GC11M059117 GC11M059098 GC11M055689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for OSBP Gene:
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the
nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase
(provided by RefSeq, Jul 2008)

GeneCards Summary for OSBP Gene:
OSBP (oxysterol binding protein) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and oxysterol binding. An important paralog of this gene is OSBPL1A.

UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex
with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its
disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability

Gene Wiki entry for OSBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OSBP gene promoter:
         Bach1   CBF-C   MEF-2A   CBF-B   CBF-A   aMEF-2   CP1A   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): OSBP promoter sequence
   Search Chromatin IP Primers for OSBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13

OSBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OSBP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059341:  view genomic region     (about GC identifiers)

Start:
59,341,871 bp from pter      End:
59,383,617 bp from pter
Size:
41,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059 (See protein sequence)
Recommended Name: Oxysterol-binding protein 1  
Size: 807 amino acids; 89421 Da
Subunit: Homodimer or homotrimer. Interacts with VAPA
Sequence caution: Sequence=AAH63121.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
1 PDB 3D structure from and Proteopedia for OSBP:
2RR3 (3D)    
Secondary accessions: Q6P524

Explore the universe of human proteins at neXtProt for OSBP: NX_P22059

Explore proteomics data for OSBP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OSBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002547.1  
    ENSEMBL proteins: 
     ENSP00000263847   ENSP00000432399  
    Reactome Protein details: P22059

    OSBP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OSBP
    OriGene Protein Over-expression Lysate for OSBP
    OriGene MassSpec for OSBP
    OriGene Custom Protein Services for OSBP
    GenScript Custom Purified and Recombinant Proteins Services for OSBP
    Novus Biologicals OSBP Protein
    Novus Biologicals OSBP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OSBP

     
    Search eBioscience for Proteins for OSBP 

     
    antibodies-online proteins for OSBP (2 products) 

     
    antibodies-online peptides for OSBP

    OSBP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OSBP
    OriGene Custom Antibody Services for OSBP
    Novus Biologicals OSBP Antibodies
    Abcam antibodies for OSBP
    Cloud-Clone Corp. Antibodies for OSBP
    ThermoFisher Antibody for OSBP
    antibodies-online antibodies for OSBP (25 products) 

    OSBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OSBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OSBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OSBP
    Cloud-Clone Corp. CLIAs for OSBP
    Search eBioscience for ELISAs for OSBP 
    antibodies-online kits for OSBP (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    OSBP: Oxysterol binding proteins
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000648 Oxysterol-bd
     IPR018494 Oxysterol-bd_CS

    Graphical View of Domain Structure for InterPro Entry P22059

    ProtoNet protein and cluster: P22059

    2 Blocks protein domains:
    IPB000648 Oxysterol-binding protein
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
    Domain: The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol
    binding (By similarity)
    Domain: The second coiled-coil domain is required for interaction with the tyrosine phosphatase (By similarity)
    Similarity: Belongs to the OSBP family
    Similarity: Contains 1 PH domain


    Find genes that share domains with OSBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSBP1_HUMAN, P22059
    Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex
    with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its
    disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability

         Genatlas biochemistry entry for OSBP:
    oxysterol binding protein,involved in the regulation of cholesterol metabolism

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008142oxysterol binding TAS1970801
         
    Find genes that share ontologies with OSBP           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OSBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target OSBP:
    hsa-mir-335-5p (MIRT019139), hsa-mir-505-3p (MIRT041032), hsa-mir-124-3p (MIRT023205), hsa-mir-365a-3p (MIRT044025)

    Block miRNA regulation of human, mouse, rat OSBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBP (see all 36):
    hsa-miR-3164 hsa-miR-29a hsa-miR-374a hsa-miR-877* hsa-miR-1244 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OSBP
    Predesigned siRNA for gene silencing in human, mouse, rat OSBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OSBP

    Clone
    Products:
         
    OriGene clones in human, mouse for OSBP (see all 6)
    OriGene ORF clones in mouse, rat for OSBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSBP (NM_002556)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
    Addgene plasmids for OSBP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OSBP
    Browse ESI BIO Cell Lines and PureStem Progenitors for OSBP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OSBP1_HUMAN, P22059: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to
    oxysterols, translocates to the periphery of Golgi membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus3
    endoplasmic reticulum2
    endosome2
    peroxisome2
    plasma membrane2
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with OSBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for OSBP About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with OSBP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OSBP
        Sphingolipid de novo biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OSBP
    Interactions:

        GeneGlobe Interaction Network for OSBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for OSBP (P220593 ENSP000002638474) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LACE1Q8WV933, ENSP000003579734I2D: score=1 STRING: ENSP00000357973
    VAPAQ9P0L03, ENSP000003456564I2D: score=3 STRING: ENSP00000345656
    SPATA5Q8NB903, ENSP000002740084I2D: score=4 STRING: ENSP00000274008
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    OSBP2Q969R23I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with OSBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OSBP (OSBP1)

    1 HMDB Compound for OSBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    25-Hydroxycholesterol(beta)-cholest-5-ene-3-25-diol (see all 8)2140-46-7--

    9 Novoseek inferred chemical compound relationships for OSBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    25-hydroxycholesterol 90.2 27 16098143 (6), 9337870 (3), 8217873 (2), 18165705 (2) (see all 10)
    sterol 77.9 33 19129476 (3), 19207211 (3), 16876994 (2), 16571669 (2) (see all 12)
    cholesterol 64 47 9337870 (5), 15746430 (5), 16098143 (4), 18165705 (4) (see all 17)
    3-hydroxy-3-methylglutaryl-coa 53 1 10364480 (1)
    lipid 52 19 15166789 (2), 20224571 (1), 18614794 (1), 15746430 (1) (see all 12)
    ceramide 48.7 11 16571669 (5), 19129476 (1), 15907394 (1), 16806880 (1)
    phosphatidylinositol 38.8 4 15635101 (1), 18614794 (1), 9268346 (1)
    phosphatidylcholine 21.3 1 18614794 (1)
    tyrosine 0 1 15746430 (1)



    Find genes that share compounds with OSBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OSBP gene: 
    NM_002556.2  

    Unigene Cluster for OSBP:

    Oxysterol binding protein
    Hs.597091  [show with all ESTs]
    Unigene Representative Sequence: AF185696
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263847(uc009ymr.1 uc001noc.1) ENST00000525357 ENST00000528903

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OSBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OSBP (see all 36):
    hsa-miR-3164 hsa-miR-29a hsa-miR-374a hsa-miR-877* hsa-miR-1244 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidOSBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OSBP
    Predesigned siRNA for gene silencing in human, mouse, rat OSBP
    Clone
    Products:
         
    OriGene clones in human, mouse for OSBP (see all 6)
    OriGene ORF clones in mouse, rat for OSBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OSBP (NM_002556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OSBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
    Addgene plasmids for OSBP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBP
      QuantiTect SYBR Green Assays in human, mouse, rat OSBP
      QuantiFast Probe-based Assays in human, mouse, rat OSBP

    Additional mRNA sequence: 

    AF185696.1 AK299071.1 AK310538.1 BC011581.1 BC017975.1 BC051350.1 BC063121.1 M86917.1 

    7 DOTS entries:

    DT.416931  DT.92414555  DT.95278062  DT.100823830  DT.95176337  DT.120713158  DT.422599 

    Selected AceView cDNA sequences (see all 299):

    BM802332 AF185696 AA368535 N76833 BM678939 BQ678531 CA429561 AA325379 
    AA489101 BM720513 AW291657 CR592861 BQ446843 BM980178 BX952624 AW298003 
    AA844035 CB305870 CB132611 BI335925 AL705332 M86917 AI590293 AU279627 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OSBP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                                                    -                                                   
    SP2:                                                                    -     -                                             
    SP3:                                                                    -     -                                             
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for OSBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OSBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACAAAAC
    OSBP Expression
    About this image


    OSBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    OSBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OSBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597091

    UniProtKB/Swiss-Prot: OSBP1_HUMAN, P22059
    Tissue specificity: Widely expressed

        Custom PCR Arrays for OSBP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OSBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBP
    QuantiTect SYBR Green Assays in human, mouse, rat OSBP
    QuantiFast Probe-based Assays in human, mouse, rat OSBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OSBP gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Osbp1 , 5 oxysterol binding protein1, 5 88.78(n)1
    93.66(a)1
      19 (8.58 cM)5
    763031  NM_001033174.11  NP_001028346.11 
     119658445 
    chicken
    (Gallus gallus)
    Aves LOC1017478931 oxysterol-binding protein 1-like 78.17(n)
    91.04(a)
      101747893  XM_004941281.1  XP_004941338.1 
    lizard
    (Anolis carolinensis)
    Reptilia OSBP6
    oxysterol binding protein
    90(a)
    1 ↔ 1
    1(91002190-91043929)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ734939.12   -- 75.84(n)    BQ734939.1 
    zebrafish
    (Danio rerio)
    Actinopterygii osbp1 oxysterol binding protein 68.62(n)
    75.66(a)
      564372  NM_001145585.1  NP_001139057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Osbp3 oxysterol binding 45(a)   96B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.17a3   -- 46(a)
    (best of 2)
      III(11329152-11342496)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWH1(YAR042W)4 Protein similar to mammalian oxysterol-binding protein; more   --   1(192619-196185) 851286  NP_009421.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORP2A1 ORP2A 46.51(n)
    37.01(a)
      828349  NM_118380.2  NP_567662.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01549001 Os08g0154900 46.26(n)
    38.13(a)
      4344687  NM_001067552.1  NP_001061017.1 


    ENSEMBL Gene Tree for OSBP (if available)
    TreeFam Gene Tree for OSBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OSBP gene
    OSBPL1A2  OSBPL32  OSBPL72  OSBP22  OSBPL22  OSBPL62  
    3 SIMAP similar genes for OSBP using alignment to 2 protein entries:     OSBP1_HUMAN (see all proteins):
    OSBP2    OSBPL2    OSBPL1A

    Find genes that share paralogs with OSBP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OSBP (see all 798)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360994
    A colorectal cancer sample4--see VAR_0360992 D A mis40--------
    rs1916714761,2
    --59341390(+) TACTTC/GGGGAG 1 -- ds50010--------
    rs1380506491,2
    --59341417(+) CGCTTC/GAGCCT 1 -- ds50010--------
    rs5030181,2
    C,F,A,H--59341429(+) GGAGGC/TGGATG 1 -- ds500119Minor allele frequency- T:0.08NS EA NA WA CSA 797
    rs1416186801,2
    --59341765(+) CTTCTA/GGGCGC 1 -- ds50010--------
    rs1505229581,2
    --59341768(+) CTGGGC/TGCTCA 1 -- ds50010--------
    rs1840013231,2
    --59342024(+) AATCTA/GATTGG 1 -- ut310--------
    rs57921511,2
    C--59342128(+) CCCCGG/-ATGAG 1 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs82801,2
    C,F,A,H--59342178(+) CATAAT/CCCCTG 1 -- ut31 ese327Minor allele frequency- C:0.20MN NA NS EA WA CSA 2851
    rs763136181,2
    C,F--59342271(+) AGGAAG/AGGATA 1 -- ut311Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for OSBP (59341871 - 59383617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OSBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26905CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OSBP
    DNA2.0 Custom Variant and Variant Library Synthesis for OSBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 167040    OMIM disorders: --


    Find genes that share disorders with OSBP           About GenesLikeMe

    2 Novoseek inferred disease relationships for OSBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 16.9 1 11295104 (1)
    atherosclerosis 0 1 15768828 (1)

    Genetic Association Database (GAD): OSBP
    Human Genome Epidemiology (HuGE) Navigator: OSBP (5 documents)

    Export disorders for OSBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OSBP gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with OSBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. (PubMed id 1970801)1, 2, 9 Levanon D.... Goldstein J.L. (Genomics 1990)
    2. OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. (PubMed id 15746430)1, 2, 9 Wang P.-Y.... Anderson R.G.W. (Science 2005)
    3. Electrostatic interaction between oxysterol-binding protein and VAMP- associated protein A revealed by NMR and mutagenesis studies. (PubMed id 20178991)1, 2, 9 Furuita K.... Kojima C. (J. Biol. Chem. 2010)
    4. Molecular and biochemical characterization of a novel oxysterol- binding protein (OSBP2) highly expressed in retina. (PubMed id 11278871)1, 2, 9 Moreira E.F.... Rodriguez I.R. (J. Biol. Chem. 2001)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. (PubMed id 16571669)1, 9 Perry R.J. and Ridgway N.D. (Mol. Biol. Cell 2006)
    9. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. (PubMed id 10588946)1, 9 Laitinen S....Ikonen E. (J. Lipid Res. 1999)
    10. The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP. (PubMed id 18165705)1, 9 Wang P.Y....Anderson R.G. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5007 HGNC: 8503 AceView: OSBP Ensembl:ENSG00000110048 euGenes: HUgn5007
    ECgene: OSBP H-InvDB: OSBP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OSBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OSBP gene:
    Search GeneIP for patents involving OSBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OSBP   OriGene RNAi products in human, mouse, rat for OSBP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OSBP  
     OriGene MassSpec for OSBP   OriGene clones in human, mouse for OSBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for OSBP   OriGene Purified Protein for OSBP  
     OriGene ORF clones in mouse, rat for OSBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OSBP   OriGene Custom Protein Services for OSBP  

     
     
     Block miRNA regulation of human, mouse, rat OSBP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OSBP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OSBP Predesigned siRNA for gene silencing in human, mouse, rat OSBP
     QuantiFast Probe-based Assays in human, mouse, rat OSBP QuantiTect SYBR Green Assays in human, mouse, rat OSBP
     Custom PCR Arrays for OSBP Search Chromatin IP Primers for OSBP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OSBP  GeneGlobe Interaction Network for OSBP
     Regulatory tfbs in OSBP promoter
     GenScript Custom Purified and Recombinant Proteins Services for OSBP GenScript cDNA clones with any tag delivered in your preferred vector for OSBP
     GenScript Custom Assay Services for OSBP GenScript Custom overexpressing Cell Line Services for OSBP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OSBP (OSBP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OSBP antibodies
     OSBP proteins
     OSBP lysates
     Antibodies for OSBP
     See all of Abcam's Antibodies, Kits and Proteins for OSBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OSBP
     Antibodies for OSBP
     ELISAs for OSBP
     CLIAs for OSBP



     Browse ESI BIO Cell Lines and PureStem Progenitors for OSBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OSBP
     SwitchGear 3'UTR luciferase reporter plasmids for OSBP
     SwitchGear Promoter luciferase reporter plasmids for OSBP
     ThermoFisher Antibody for OSBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OSBP
     Browse compounds at ApexBio
     Addgene plasmids for OSBP
      Search eBioscience for proteins for OSBP
      Search eBioscience for elisas for OSBP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OSBP
     antibodies-online antibodies for OSBP (25 products)
     antibodies-online kits for OSBP (6 products)
     antibodies-online peptides for OSBP
     antibodies-online proteins for OSBP (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OSBP gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4